Sekar Kathiresan

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc Biological, clinical and population relevance of 95 loci for blood lipids
    Tanya M Teslovich
    Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nature 466:707-13. 2010
  2. pmc Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study
    Benjamin F Voight
    Department of Pharmacology, University of Pennsylvania, Philadelphia, PA, USA
    Lancet 380:572-80. 2012
  3. pmc Genetics of human cardiovascular disease
    Sekar Kathiresan
    Center for Human Genetic Research and Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA
    Cell 148:1242-57. 2012
  4. pmc A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study
    Sekar Kathiresan
    National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S17. 2007
  5. pmc Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans
    Sekar Kathiresan
    Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Nat Genet 40:189-97. 2008
  6. doi request reprint Polymorphisms associated with cholesterol and risk of cardiovascular events
    Sekar Kathiresan
    Cardiovascular Disease Prevention Center, Cardiology Division, Massachusetts General Hospital, MA 02114, USA
    N Engl J Med 358:1240-9. 2008
  7. doi request reprint Defining the spectrum of alleles that contribute to blood lipid concentrations in humans
    Sekar Kathiresan
    Cardiovascular Disease Prevention Center, Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Curr Opin Lipidol 19:122-7. 2008
  8. ncbi request reprint Contribution of clinical correlates and 13 C-reactive protein gene polymorphisms to interindividual variability in serum C-reactive protein level
    Sekar Kathiresan
    Framingham Heart Study, Framingham, MA 01702 5827, USA
    Circulation 113:1415-23. 2006
  9. pmc Fine-mapping in African Americans of 8 recently discovered genetic loci for plasma lipids: the Jackson Heart Study
    Mary E Keebler
    Massachusetts General Hospital, Boston, MA 02115, USA
    Circ Cardiovasc Genet 3:358-64. 2010
  10. pmc Genetic differences between the determinants of lipid profile phenotypes in African and European Americans: the Jackson Heart Study
    Rahul C Deo
    Department of Genetics, Harvard Medical School, Boston, MA, USA
    PLoS Genet 5:e1000342. 2009

Detail Information

Publications79

  1. pmc Biological, clinical and population relevance of 95 loci for blood lipids
    Tanya M Teslovich
    Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nature 466:707-13. 2010
    ..Taken together, our findings provide the foundation to develop a broader biological understanding of lipoprotein metabolism and to identify new therapeutic opportunities for the prevention of CAD...
  2. pmc Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study
    Benjamin F Voight
    Department of Pharmacology, University of Pennsylvania, Philadelphia, PA, USA
    Lancet 380:572-80. 2012
    ....
  3. pmc Genetics of human cardiovascular disease
    Sekar Kathiresan
    Center for Human Genetic Research and Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA
    Cell 148:1242-57. 2012
    ....
  4. pmc A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study
    Sekar Kathiresan
    National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S17. 2007
    ..Genome-wide association is a promising approach to map genetic loci related to these heritable phenotypes...
  5. pmc Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans
    Sekar Kathiresan
    Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Nat Genet 40:189-97. 2008
    ..Understanding the molecular, cellular and clinical consequences of the newly identified loci may inform therapy and clinical care...
  6. doi request reprint Polymorphisms associated with cholesterol and risk of cardiovascular events
    Sekar Kathiresan
    Cardiovascular Disease Prevention Center, Cardiology Division, Massachusetts General Hospital, MA 02114, USA
    N Engl J Med 358:1240-9. 2008
    ..We tested the hypothesis that a combination of such SNPs contributes to the risk of cardiovascular disease...
  7. doi request reprint Defining the spectrum of alleles that contribute to blood lipid concentrations in humans
    Sekar Kathiresan
    Cardiovascular Disease Prevention Center, Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Curr Opin Lipidol 19:122-7. 2008
    ..This review summarizes recent genome-wide association studies for lipid phenotypes, and evaluates the next steps needed to obtain a full picture of genotype-phenotype correlation and apply these findings to inform clinical practice...
  8. ncbi request reprint Contribution of clinical correlates and 13 C-reactive protein gene polymorphisms to interindividual variability in serum C-reactive protein level
    Sekar Kathiresan
    Framingham Heart Study, Framingham, MA 01702 5827, USA
    Circulation 113:1415-23. 2006
    ..Serum C-reactive protein (CRP) level is a heritable complex trait that predicts incident cardiovascular disease. We investigated the clinical and genetic sources of interindividual variability in serum CRP...
  9. pmc Fine-mapping in African Americans of 8 recently discovered genetic loci for plasma lipids: the Jackson Heart Study
    Mary E Keebler
    Massachusetts General Hospital, Boston, MA 02115, USA
    Circ Cardiovasc Genet 3:358-64. 2010
    ..Genome-wide association studies in cohorts of European descent have identified novel genomic regions as associated with lipids, but their relevance in African Americans remains unclear...
  10. pmc Genetic differences between the determinants of lipid profile phenotypes in African and European Americans: the Jackson Heart Study
    Rahul C Deo
    Department of Genetics, Harvard Medical School, Boston, MA, USA
    PLoS Genet 5:e1000342. 2009
    ....
  11. pmc Multiple inflammatory biomarkers in relation to cardiovascular events and mortality in the community
    Renate B Schnabel
    Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, MA, USA
    Arterioscler Thromb Vasc Biol 33:1728-33. 2013
    ..Evidence suggests that chronic low-grade inflammation and oxidative stress are related to cardiovascular disease (CVD) and mortality...
  12. pmc Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study
    Ramachandran S Vasan
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S2. 2007
    ..We conducted a genome-wide association study (GWAS) in the community-based Framingham Heart Study...
  13. pmc Biomarkers of the osteoprotegerin pathway: clinical correlates, subclinical disease, incident cardiovascular disease, and mortality
    Wolfgang Lieb
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Mass, USA
    Arterioscler Thromb Vasc Biol 30:1849-54. 2010
    ..Experimental evidence identified the osteoprotegerin (OPG)/receptor activator of nuclear factor-kappaB (RANK)/RANK ligand (RANKL) pathway as a candidate system modulating vascular remodeling and cardiovascular disease (CVD)...
  14. pmc Association of blood lipids with common DNA sequence variants at 19 genetic loci in the multiethnic United States National Health and Nutrition Examination Survey III
    Mary E Keebler
    Massachusetts General Hospital, Boston, MA 02115, USA
    Circ Cardiovasc Genet 2:238-43. 2009
    ..Whether these same SNPs associate with lipids in a broader range of ethnicities is unknown...
  15. pmc Association of common variants in NPPA and NPPB with circulating natriuretic peptides and blood pressure
    Christopher Newton-Cheh
    Center for Human Genetic Research, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA
    Nat Genet 41:348-53. 2009
    ..85-0.95, P = 2 x 10(-4), respectively). Common genetic variants at the NPPA-NPPB locus found to be associated with circulating natriuretic peptide concentrations contribute to interindividual variation in blood pressure and hypertension...
  16. pmc Relation of multiple inflammatory biomarkers to incident atrial fibrillation
    Renate B Schnabel
    National Heart Lung Blood Institute Framingham Study, Framingham, MA, USA
    Am J Cardiol 104:92-6. 2009
    ..18, 95% confidence interval 0.98 to 1.43, p = 0.09). In conclusion, circulating osteoprotegerin concentration was significantly associated with incident AF in our community-based sample, possibly mediated by interim cardiovascular events...
  17. pmc Small dense low-density lipoprotein-cholesterol concentrations predict risk for coronary heart disease: the Atherosclerosis Risk In Communities (ARIC) study
    Ron C Hoogeveen
    From the Department of Medicine, Baylor College of Medicine and Methodist DeBakey Heart and Vascular Center, Houston, TX R C H, J W G, W S, J J, S S V, C M B Human Genetics Center, University of Texas Health Science Center School of Public Health, Houston R C D, J R C, E B Department of Biostatistics, University of North Carolina at Chapel Hill D C Michael E DeBakey Veterans Affairs Medical Center, Houston, TX S S V Center for Human Genetic Research and Cardiovascular Research Center, Massachusetts General Hospital, Boston S K and Department of Medicine, Harvard Medical School, Boston, MA S K
    Arterioscler Thromb Vasc Biol 34:1069-77. 2014
    ....
  18. ncbi request reprint Clinical and genetic correlates of aldosterone-to-renin ratio and relations to blood pressure in a community sample
    Christopher Newton-Cheh
    Framingham Heart Study of the National Heart Lung and Blood Institute and Boston University School of Medicine, Framingham, MA 01702 5827, USA
    Hypertension 49:846-56. 2007
    ..16; 95% CI: 1.00 to 1.33). ARR is a heritable trait influenced by clinical and genetic factors. There is a continuous gradient of increasing risk of BP progression across ARR levels in nonhypertensive individuals...
  19. pmc Genome-wide association with select biomarker traits in the Framingham Heart Study
    Emelia J Benjamin
    The National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S11. 2007
    ..Genome-wide association studies (GWAS) provide mechanisms to investigate the genetic contributions to biomarker variability unconstrained by current knowledge of physiological relations...
  20. ncbi request reprint PAI-1 Gene 4G/5G polymorphism and risk of type 2 diabetes in a population-based sample
    James B Meigs
    General Medicine Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Obesity (Silver Spring) 14:753-8. 2006
    ..Elevated PAI-1 levels may be associated with an increased risk for diabetes as a marker for underlying endothelial dysfunction rather than by a direct effect of genetically mediated elevated levels...
  21. pmc Pericardial fat volume correlates with inflammatory markers: the Framingham Heart Study
    Thomas M Tadros
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Boston, Massachusetts, USA
    Obesity (Silver Spring) 18:1039-45. 2010
    ..Multiple markers of inflammation and oxidative stress correlated with pericardial and intrathoracic fat volumes, extending the known association between regional adiposity and inflammation and oxidative stress...
  22. pmc Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study
    Qiong Yang
    The National Heart, Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S12. 2007
    ..We sought to confirm known putative loci and identify novel loci that may influence either trait in genome-wide association and linkage analyses using the Affymetrix GeneChip 100K single nucleotide polymorphism (SNP) set...
  23. ncbi request reprint Common genetic variation in five thrombosis genes and relations to plasma hemostatic protein level and cardiovascular disease risk
    Sekar Kathiresan
    National Heart, Lung, and Blood Institute Framingham Heart Study, Framingham, MA 01702 5827, USA
    Arterioscler Thromb Vasc Biol 26:1405-12. 2006
    ..We undertook a linkage disequilibrium (LD)-based genetic approach to investigate the hypothesis that common sequence variants in 5 thrombosis genes influence plasma hemostatic protein levels or risk of cardiovascular disease (CVD)...
  24. pmc Novel genetic markers associate with atrial fibrillation risk in Europeans and Japanese
    Steven A Lubitz
    Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston, Massachusetts Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts Electronic address
    J Am Coll Cardiol 63:1200-10. 2014
    ..This study sought to identify nonredundant atrial fibrillation (AF) genetic susceptibility signals and examine their cumulative relations with AF risk...
  25. ncbi request reprint Cross-sectional relations of multiple biomarkers from distinct biological pathways to brachial artery endothelial function
    Sekar Kathiresan
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA 01702 5827, USA
    Circulation 113:938-45. 2006
    ..We evaluated the relative contributions of distinct biological pathways to interindividual variation in endothelial function by relating prototype biomarkers (representing these pathways) to brachial artery vasodilator function...
  26. pmc From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus
    Kiran Musunuru
    Cardiovascular Research Center and Center for Human Genetic Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Nature 466:714-9. 2010
    ..We also demonstrate that common noncoding DNA variants identified by GWASs can directly contribute to clinical phenotypes...
  27. pmc Inflammation, kidney function and albuminuria in the Framingham Offspring cohort
    Ashish Upadhyay
    Division of Nephrology, Tufts Medical Center and Tufts University School of Medicine, Boston, MA, USA
    Nephrol Dial Transplant 26:920-6. 2011
    ..Whether inflammatory biomarkers are associated with kidney function and albuminuria after accounting for traditional CVD risk factors is not completely understood...
  28. pmc Ion mobility analysis of lipoprotein subfractions identifies three independent axes of cardiovascular risk
    Kiran Musunuru
    Center for Human Genetic Research, Cardiology Division, Massachusetts General Hospital, Boston, MA, USA
    Arterioscler Thromb Vasc Biol 29:1975-80. 2009
    ....
  29. pmc Vitamin K and vitamin D status: associations with inflammatory markers in the Framingham Offspring Study
    M Kyla Shea
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Am J Epidemiol 167:313-20. 2008
    ..The observation that high vitamin K status was associated with lower concentrations of inflammatory markers suggests that a possible protective role for vitamin K in inflammation merits further investigation...
  30. pmc Increased burden of cardiovascular disease in carriers of APOL1 genetic variants
    Kaoru Ito
    From the Department of Genetics, Harvard Medical School, Boston, MA K I, A G B, M G P, S R D, J N H, J G S, C S Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge K I, A G B, J F, G G, N G, S B G, C N C, S K, J N H, D M A, M R P, J G S, C S Center for Human Genetic Research, Massachusetts General Hospital, Boston J F, C N C, S K, D M A Division of Nephrology, Department of Medicine D J F, G G, M R P and Center for Vascular Biology Research, Department of Medicine D J F, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston
    Circ Res 114:845-50. 2014
    ..Approximately 14% of Americans with African ancestry carry 2 APOL1 risk alleles, accounting for the high chronic kidney disease burden in this population...
  31. ncbi request reprint Visceral and subcutaneous adipose tissue volumes are cross-sectionally related to markers of inflammation and oxidative stress: the Framingham Heart Study
    Karla M Pou
    Division of Endocrinology, Metabolism, and Diabetes, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass, USA
    Circulation 116:1234-41. 2007
    ..Excess adiposity is associated with greater systemic inflammation. Whether visceral adiposity is more proinflammatory than subcutaneous abdominal adiposity is unclear...
  32. pmc The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports
    L Adrienne Cupples
    National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S1. 2007
    ....
  33. ncbi request reprint Comprehensive survey of common genetic variation at the plasminogen activator inhibitor-1 locus and relations to circulating plasminogen activator inhibitor-1 levels
    Sekar Kathiresan
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts 01702 5827, USA
    Circulation 112:1728-35. 2005
    ....
  34. pmc Relations of long-term and contemporary lipid levels and lipid genetic risk scores with coronary artery calcium in the framingham heart study
    Connie W Tsao
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA 01702, USA
    J Am Coll Cardiol 60:2364-71. 2012
    ..This study evaluated the association of timing of lipid levels and lipid genetic risk score (GRS) with subclinical atherosclerosis...
  35. pmc Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacks
    Gina M Peloso
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA Department of Medicine, Harvard Medical School, Boston, MA 02115, USA Program in Medical and Population Genetics, Broad Institute, Cambridge, MA 02142, USA
    Am J Hum Genet 94:223-32. 2014
    ..None of these four variants was associated with risk for CHD, suggesting that examples of low-frequency coding variants with robust effects on both lipids and CHD will be limited...
  36. ncbi request reprint Heritability, linkage, and genetic associations of exercise treadmill test responses
    Erik Ingelsson
    Framingham Study, Framingham, Mass, USA
    Circulation 115:2917-24. 2007
    ..The blood pressure (BP) and heart rate responses to exercise treadmill testing predict incidence of cardiovascular disease, but the genetic determinants of hemodynamic and chronotropic responses to exercise are largely unknown...
  37. pmc Common variants at 30 loci contribute to polygenic dyslipidemia
    Sekar Kathiresan
    Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Nat Genet 41:56-65. 2009
    ..These results suggest that the cumulative effect of multiple common variants contributes to polygenic dyslipidemia...
  38. ncbi request reprint Cardiac troponin T elevation after coronary artery bypass grafting is associated with increased one-year mortality
    Sekar Kathiresan
    Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Am J Cardiol 94:879-81. 2004
    ....
  39. ncbi request reprint Assessment by cardiovascular magnetic resonance, electron beam computed tomography, and carotid ultrasonography of the distribution of subclinical atherosclerosis across Framingham risk strata
    Sekar Kathiresan
    Framingham Heart Study, Framingham, Massachusetts, USA
    Am J Cardiol 99:310-4. 2007
    ..In conclusion, in a community-based sample, correlations among subclinical atherosclerosis test results are low, and a substantial proportion has high levels of subclinical atherosclerosis detected on >or=2 imaging tests...
  40. pmc Assessing the phenotypic effects in the general population of rare variants in genes for a dominant Mendelian form of diabetes
    Jason Flannick
    1 Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology MIT, Cambridge, Massachusetts, USA 2 Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, USA 3 Diabetes Unit, Massachusetts General Hospital, Boston, Massachusetts, USA 4
    Nat Genet 45:1380-5. 2013
    ..Accurate estimates of variant effect sizes from population-based sequencing are needed to avoid falsely predicting a substantial fraction of individuals as being at risk for MODY or other Mendelian diseases...
  41. pmc Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data
    Ramachandran S Vasan
    Framingham Heart Study, 73 Mt Wayte Ave, Ste 2, Framingham, MA 01702 5827, USA
    JAMA 302:168-78. 2009
    ..Echocardiographic measures of left ventricular (LV) structure and function are heritable phenotypes of cardiovascular disease...
  42. pmc Genome-wide association study identifies eight loci associated with blood pressure
    Christopher Newton-Cheh
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA
    Nat Genet 41:666-76. 2009
    ..These associations between common variants and blood pressure and hypertension offer mechanistic insights into the regulation of blood pressure and may point to novel targets for interventions to prevent cardiovascular disease...
  43. ncbi request reprint Common genetic variation at the endothelial nitric oxide synthase locus and relations to brachial artery vasodilator function in the community
    Sekar Kathiresan
    Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, MA, USA
    Circulation 112:1419-27. 2005
    ..Sequence variants at the endothelial nitric oxide synthase (NOS3) locus have been associated with endothelial function measures, but replication has been limited...
  44. pmc Loss-of-function mutations in SLC30A8 protect against type 2 diabetes
    Jason Flannick
    1 Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA 2 Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, USA 3 Diabetes Unit, Massachusetts General Hospital, Boston, Massachusetts, USA
    Nat Genet 46:357-63. 2014
    ..In contrast, loss-of-function mutations in humans provide strong evidence that SLC30A8 haploinsufficiency protects against T2D, suggesting ZnT8 inhibition as a therapeutic strategy in T2D prevention. ..
  45. ncbi request reprint Increased small low-density lipoprotein particle number: a prominent feature of the metabolic syndrome in the Framingham Heart Study
    Sekar Kathiresan
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    Circulation 113:20-9. 2006
    ..However, the atherogenic potential of LDL may depend on the number and size of LDL particles in addition to the cholesterol content of LDL...
  46. pmc Meta-analysis identifies six new susceptibility loci for atrial fibrillation
    Patrick T Ellinor
    Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, Massachusetts, USA
    Nat Genet 44:670-5. 2012
    ..The identified loci implicate candidate genes that encode transcription factors related to cardiopulmonary development, cardiac-expressed ion channels and cell signaling molecules...
  47. pmc Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants
    Sekar Kathiresan
    Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Nat Genet 41:334-41. 2009
    ..SNPs at nine loci were reproducibly associated with myocardial infarction, but tests of common and rare CNVs failed to identify additional associations with myocardial infarction risk...
  48. pmc Glycated albumin and direct low density lipoprotein cholesterol levels in type 2 diabetes mellitus
    Masumi Ai
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Clin Chim Acta 406:71-4. 2009
    ....
  49. pmc Association between glucokinase regulatory protein (GCKR) and apolipoprotein A5 (APOA5) gene polymorphisms and triacylglycerol concentrations in fasting, postprandial, and fenofibrate-treated states
    Pablo Perez-Martinez
    Nutrition and Genomics Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    Am J Clin Nutr 89:391-9. 2009
    ..Hypertriglyceridemia is a risk factor for cardiovascular disease. Variation in the apolipoprotein A5 (APOA5) and glucokinase regulatory protein (GCKR) genes has been associated with fasting plasma triacylglycerol...
  50. pmc Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation
    Jie Huang
    National Heart, Lung, and Blood Institute NHBLI Framingham Heart Study, Framingham, MA 01702, USA
    Blood 120:4873-81. 2012
    ..1. In summary, SNPs in SERPINE1 and ARNTL and an SNP associated with the expression of MUC3 were robustly associated with circulating levels of PAI-1...
  51. pmc Genome-wide association study for coronary artery calcification with follow-up in myocardial infarction
    Christopher J O'Donnell
    MPH, NHLBI s Framingham Heart Study, 73 Mount Wayte Ave, Suite 2, Framingham, MA 01702, USA
    Circulation 124:2855-64. 2011
    ..We sought to identify common genetic variants associated with CAC and further investigate their associations with MI...
  52. ncbi request reprint Genetics of coronary artery disease
    Kiran Musunuru
    Center for Human Genetic Research and Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02108, USA
    Annu Rev Genomics Hum Genet 11:91-108. 2010
    ..A key challenge now is to move from mapping loci to pinpointing causal genes and variants, and to develop a molecular understanding of how these genes lead to coronary disease...
  53. pmc Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis
    Eli A Stahl
    Division of Rheumatology Immunology and Allergy, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Nat Genet 44:483-9. 2012
    ..These analyses suggest that GWAS will continue to be highly productive for the discovery of additional susceptibility loci for common diseases...
  54. pmc Associations of long-term and early adult atherosclerosis risk factors with aortic and mitral valve calcium
    George Thanassoulis
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    J Am Coll Cardiol 55:2491-8. 2010
    ..To determine the association of long-term exposure to atherosclerosis risk factors with valvular calcification...
  55. pmc Exome sequencing, ANGPTL3 mutations, and familial combined hypolipidemia
    Kiran Musunuru
    Cardiovascular Research Center, Massachusetts General Hospital, and Department of Medicine, Boston University School of Public Health, Boston, MA 02114, USA
    N Engl J Med 363:2220-7. 2010
    ..Funded by the National Human Genome Research Institute and others.)...
  56. ncbi request reprint Non-invasive imaging of plaque vulnerability: an important tool for the assessment of agents to stabilise atherosclerotic plaques
    David E Sosnovik
    Division of Cardiology, CIMIT Massachusetts General Hospital, Boston, MA 02114, USA
    Expert Opin Investig Drugs 11:693-704. 2002
    ..This knowledge will be extremely important for physicians and scientists involved in the clinical evaluation of novel agents to stabilise the vulnerable plaque...
  57. pmc Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways
    Nicole Soranzo
    Human Genetics, Wellcome Trust Sanger Institute, Hinxton, U K
    Diabetes 59:3229-39. 2010
    ..We aimed to identify such genetic factors and investigate the extent to which they influence diabetes classification based on HbA₁(c) levels...
  58. pmc Common variants associated with plasma triglycerides and risk for coronary artery disease
    Ron Do
    1 Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA 2 Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA 3 Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA 4 Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA
    Nat Genet 45:1345-52. 2013
    ..These results suggest that triglyceride-rich lipoproteins causally influence risk for CAD. ..
  59. pmc Exome sequencing and complex disease: practical aspects of rare variant association studies
    Ron Do
    Center for Human Genetic Research and Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA
    Hum Mol Genet 21:R1-9. 2012
    ..Here, we provide practical guidance in the design and analysis of complex trait association studies focused on rare, coding variants...
  60. pmc Burden of rare sarcomere gene variants in the Framingham and Jackson Heart Study cohorts
    Alexander G Bick
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Am J Hum Genet 91:513-9. 2012
    ..3) in the FHS cohort, suggesting that cardiovascular risk assessment in the general population can benefit from rare variant analysis...
  61. pmc Aging syndrome genes and premature coronary artery disease
    Adrian F Low
    Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, and Harvard Medical School, Boston, MA, USA
    BMC Med Genet 6:38. 2005
    ..We evaluated whether common variants at the LMNA or KLOTHO genes are associated with rigorously defined premature CAD...
  62. pmc Testing for an unusual distribution of rare variants
    Benjamin M Neale
    The Center for Human Genetic Research, Massachusetts General Hospital, Boston, United States of America
    PLoS Genet 7:e1001322. 2011
    ..Through simulations and analysis of case/control data, we demonstrate good power relative to existing methods that assess the burden of rare variants in individuals...
  63. pmc Genetics of lipid disorders
    James Pirruccello
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Curr Opin Cardiol 25:238-42. 2010
    ..In this review, we will highlight recent advances in identifying genes and gene regions responsible for the variation in serum lipid levels. We will also consider the next directions for research based on these advances...
  64. pmc Assessment of 2q23.1 microdeletion syndrome implicates MBD5 as a single causal locus of intellectual disability, epilepsy, and autism spectrum disorder
    Michael E Talkowski
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Hum Genet 89:551-63. 2011
    ....
  65. ncbi request reprint Case records of the Massachusetts General Hospital. Case 14-2005. A 38-year-old man with fever and blurred vision
    Sekar Kathiresan
    Cardiology Division, Department of Medicine, Massachusetts General Hospital, Boston, USA
    N Engl J Med 352:2003-12. 2005
  66. ncbi request reprint Off-pump coronary bypass grafting is associated with less myocardial injury than coronary bypass surgery with cardiopulmonary bypass
    Sekar Kathiresan
    Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts, USA
    Heart Surg Forum 6:E174-8. 2003
    ..The present study was designed to assess the extent of myocardial injury after conventional coronary artery bypass grafting with cardio pulmonary bypass (ONCAB) compared with off-pump coronary artery bypass (OPCAB)...
  67. ncbi request reprint Clinical and genetic correlates of serum aldosterone in the community: the Framingham Heart Study
    Sekar Kathiresan
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts 01702 5827, USA
    Am J Hypertens 18:657-65. 2005
    ..We investigated the environmental and genetic sources of interindividual variability in serum aldosterone level in a large, community-based sample...
  68. ncbi request reprint New opportunities for identification and reduction of coronary risk: treatment of vulnerable patients, arteries, and plaques
    James E Muller
    Harvard Medical School, Boston, Massachusetts, USA
    J Am Coll Cardiol 47:C2-6. 2006
    ..If vulnerable plaques and patients can be successfully identified and treated, there will be immense clinical benefits, accompanied by cost savings...
  69. pmc Increased plasma osteoprotegerin concentrations are associated with indices of bone strength of the hip
    Elizabeth J Samelson
    Institute for Aging Research, Hebrew SeniorLife, 1200 Centre Street, Boston, MA 02131, USA
    J Clin Endocrinol Metab 93:1789-95. 2008
    ..We conducted a cross-sectional study to evaluate the association between plasma OPG and femoral neck (FN) bone density (BMD) and geometry in a large cohort of women and men...
  70. ncbi request reprint A comparison of cardiac troponin T and creatine kinase-MB for patient evaluation after cardiac surgery
    James L Januzzi
    Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Am Coll Cardiol 39:1518-23. 2002
    ..The aim of this study was to assess the role of serum markers of myocardial necrosis after cardiac surgery...
  71. ncbi request reprint Clinician update: direct thrombin inhibitors in acute coronary syndromes
    Joanna J Wykrzykowska
    Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Thromb Thrombolysis 15:47-57. 2003
    ..As the knowledge of more appropriate use of these drugs progressed, there is a renewed interest in DTIs. Herein we will review the clinical studies assessing hirudin, bivalirudin and argatroban in the settings of AMI, UA and PCI...
  72. pmc On the significance of linkage studies of complex traits
    Christopher Newton-Cheh
    Am J Hum Genet 75:151-2; author reply 152-4. 2004
  73. pmc Bayesian meta-analysis of genetic association studies with different sets of markers
    Claudio Verzilli
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
    Am J Hum Genet 82:859-72. 2008
    ..The same method could be applied to evidence synthesis of other quantitative traits, whenever the typed SNPs vary among studies, and to assist fine mapping of causal variants...
  74. ncbi request reprint Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
    Richa Saxena
    Broad Institute of Harvard and Massachusetts Institute of Technology MIT, Cambridge, MA 02142, USA
    Science 316:1331-6. 2007
    ..The discovery of associated variants in unsuspected genes and outside coding regions illustrates the ability of genome-wide association studies to provide potentially important clues to the pathogenesis of common diseases...
  75. ncbi request reprint Vascular stiffness and genetic variation at the endothelial nitric oxide synthase locus: the Framingham Heart study
    Gary F Mitchell
    Cardiovascular Engineering, Inc, Waltham, MA 02453, USA
    Hypertension 49:1285-90. 2007
    ..The present study was suggestive of modest relations between common genetic variants at the NOS3 locus and arterial stiffness...
  76. ncbi request reprint CCL2 polymorphisms are associated with serum monocyte chemoattractant protein-1 levels and myocardial infarction in the Framingham Heart Study
    David H McDermott
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1886, USA
    Circulation 112:1113-20. 2005
    ..Monocyte chemoattractant protein-1 (MCP-1) is a chemokine strongly implicated in promoting atherosclerosis in animal models, but human genetic evidence is contradictory...
  77. ncbi request reprint Algorithms for assessing cardiovascular risk in women
    Thomas J Wang
    JAMA 298:176; author reply 177-8. 2007
  78. ncbi request reprint On the interpretation of genetic association studies
    Sekar Kathiresan
    Eur Heart J 25:1378-81. 2004
  79. doi request reprint A PCSK9 missense variant associated with a reduced risk of early-onset myocardial infarction
    Sekar Kathiresan
    N Engl J Med 358:2299-300. 2008

Research Grants2

  1. Osteoprotegerin Pathway: Relations of Genes & Biomarkers to CVD in the Community
    Sekar Kathiresan; Fiscal Year: 2007
    ..In addition, the candidate will be well positioned to transition from conducting pathway-based investigation to genome-wide association studies for cardiovascular phenotypes. [unreadable] [unreadable]..
  2. Osteoprotegerin Pathway: Relations of Genes & Biomarkers to CVD in the Community
    Sekar Kathiresan; Fiscal Year: 2008
    ..In addition, the candidate will be well positioned to transition from conducting pathway-based investigation to genome-wide association studies for cardiovascular phenotypes. [unreadable] [unreadable]..