Research Topics
Genomes and Genes
| Sekar KathiresanSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
Research Grants
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Detail Information
Publications
Genetics of human cardiovascular diseaseSekar Kathiresan
Center for Human Genetic Research and Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA
Cell 148:1242-57. 2012....
Polymorphisms associated with cholesterol and risk of cardiovascular eventsSekar Kathiresan
Cardiovascular Disease Prevention Center, Cardiology Division, Massachusetts General Hospital, MA 02114, USA
N Engl J Med 358:1240-9. 2008..We tested the hypothesis that a combination of such SNPs contributes to the risk of cardiovascular disease...- Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humansSekar Kathiresan
Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Nat Genet 40:189-97. 2008..Understanding the molecular, cellular and clinical consequences of the newly identified loci may inform therapy and clinical care... - Defining the spectrum of alleles that contribute to blood lipid concentrations in humansSekar Kathiresan
Cardiovascular Disease Prevention Center, Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Curr Opin Lipidol 19:122-7. 2008..This review summarizes recent genome-wide association studies for lipid phenotypes, and evaluates the next steps needed to obtain a full picture of genotype-phenotype correlation and apply these findings to inform clinical practice... - A genome-wide association study for blood lipid phenotypes in the Framingham Heart StudySekar Kathiresan
National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
BMC Med Genet 8:S17. 2007..Genome-wide association is a promising approach to map genetic loci related to these heritable phenotypes... 
Contribution of clinical correlates and 13 C-reactive protein gene polymorphisms to interindividual variability in serum C-reactive protein levelSekar Kathiresan
Framingham Heart Study, Framingham, MA 01702 5827, USA
Circulation 113:1415-23. 2006..Serum C-reactive protein (CRP) level is a heritable complex trait that predicts incident cardiovascular disease. We investigated the clinical and genetic sources of interindividual variability in serum CRP...- Fine-mapping in African Americans of 8 recently discovered genetic loci for plasma lipids: the Jackson Heart StudyMary E Keebler
Massachusetts General Hospital, Boston, MA 02115, USA
Circ Cardiovasc Genet 3:358-64. 2010..Genome-wide association studies in cohorts of European descent have identified novel genomic regions as associated with lipids, but their relevance in African Americans remains unclear... - Genetic differences between the determinants of lipid profile phenotypes in African and European Americans: the Jackson Heart StudyRahul C Deo
Department of Genetics, Harvard Medical School, Boston, MA, USA
PLoS Genet 5:e1000342. 2009.... - Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart StudyRamachandran S Vasan
The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
BMC Med Genet 8:S2. 2007..We conducted a genome-wide association study (GWAS) in the community-based Framingham Heart Study... - Relation of multiple inflammatory biomarkers to incident atrial fibrillationRenate B Schnabel
National Heart Lung Blood Institute Framingham Study, Framingham, MA, USA
Am J Cardiol 104:92-6. 2009..18, 95% confidence interval 0.98 to 1.43, p = 0.09). In conclusion, circulating osteoprotegerin concentration was significantly associated with incident AF in our community-based sample, possibly mediated by interim cardiovascular events... - Biomarkers of the osteoprotegerin pathway: clinical correlates, subclinical disease, incident cardiovascular disease, and mortalityWolfgang Lieb
National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Mass, USA
Arterioscler Thromb Vasc Biol 30:1849-54. 2010..Experimental evidence identified the osteoprotegerin (OPG)/receptor activator of nuclear factor-kappaB (RANK)/RANK ligand (RANKL) pathway as a candidate system modulating vascular remodeling and cardiovascular disease (CVD)... - Association of common variants in NPPA and NPPB with circulating natriuretic peptides and blood pressureChristopher Newton-Cheh
Center for Human Genetic Research, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA
Nat Genet 41:348-53. 2009..85-0.95, P = 2 x 10(-4), respectively). Common genetic variants at the NPPA-NPPB locus found to be associated with circulating natriuretic peptide concentrations contribute to interindividual variation in blood pressure and hypertension... - Association of blood lipids with common DNA sequence variants at 19 genetic loci in the multiethnic United States National Health and Nutrition Examination Survey IIIMary E Keebler
Massachusetts General Hospital, Boston, MA 02115, USA
Circ Cardiovasc Genet 2:238-43. 2009..Whether these same SNPs associate with lipids in a broader range of ethnicities is unknown... - PAI-1 Gene 4G/5G polymorphism and risk of type 2 diabetes in a population-based sampleJames B Meigs
General Medicine Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Obesity (Silver Spring) 14:753-8. 2006..Elevated PAI-1 levels may be associated with an increased risk for diabetes as a marker for underlying endothelial dysfunction rather than by a direct effect of genetically mediated elevated levels... - Genome-wide association with select biomarker traits in the Framingham Heart StudyEmelia J Benjamin
The National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
BMC Med Genet 8:S11. 2007..Genome-wide association studies (GWAS) provide mechanisms to investigate the genetic contributions to biomarker variability unconstrained by current knowledge of physiological relations... - Clinical and genetic correlates of aldosterone-to-renin ratio and relations to blood pressure in a community sampleChristopher Newton-Cheh
Framingham Heart Study of the National Heart Lung and Blood Institute and Boston University School of Medicine, Framingham, MA 01702 5827, USA
Hypertension 49:846-56. 2007..16; 95% CI: 1.00 to 1.33). ARR is a heritable trait influenced by clinical and genetic factors. There is a continuous gradient of increasing risk of BP progression across ARR levels in nonhypertensive individuals... - Pericardial fat volume correlates with inflammatory markers: the Framingham Heart StudyThomas M Tadros
National Heart, Lung, and Blood Institute s Framingham Heart Study, Boston, Massachusetts, USA
Obesity (Silver Spring) 18:1039-45. 2010..Multiple markers of inflammation and oxidative stress correlated with pericardial and intrathoracic fat volumes, extending the known association between regional adiposity and inflammation and oxidative stress... - Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart StudyQiong Yang
The National Heart, Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
BMC Med Genet 8:S12. 2007..We sought to confirm known putative loci and identify novel loci that may influence either trait in genome-wide association and linkage analyses using the Affymetrix GeneChip 100K single nucleotide polymorphism (SNP) set... - Cross-sectional relations of multiple biomarkers from distinct biological pathways to brachial artery endothelial functionSekar Kathiresan
National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA 01702-5827, USA
Circulation 113:938-45. 2006.... - Vitamin K and vitamin D status: associations with inflammatory markers in the Framingham Offspring StudyM Kyla Shea
Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
Am J Epidemiol 167:313-20. 2008..The observation that high vitamin K status was associated with lower concentrations of inflammatory markers suggests that a possible protective role for vitamin K in inflammation merits further investigation... - Inflammation, kidney function and albuminuria in the Framingham Offspring cohortAshish Upadhyay
Division of Nephrology, Tufts Medical Center and Tufts University School of Medicine, Boston, MA, USA
Nephrol Dial Transplant 26:920-6. 2011..Whether inflammatory biomarkers are associated with kidney function and albuminuria after accounting for traditional CVD risk factors is not completely understood... - From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locusKiran Musunuru
Cardiovascular Research Center and Center for Human Genetic Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
Nature 466:714-9. 2010..We also demonstrate that common noncoding DNA variants identified by GWASs can directly contribute to clinical phenotypes... - Ion mobility analysis of lipoprotein subfractions identifies three independent axes of cardiovascular riskKiran Musunuru
Center for Human Genetic Research, Cardiology Division, Massachusetts General Hospital, Boston, MA, USA
Arterioscler Thromb Vasc Biol 29:1975-80. 2009.... - Common genetic variation in five thrombosis genes and relations to plasma hemostatic protein level and cardiovascular disease riskSekar Kathiresan
National Heart, Lung, and Blood Institute Framingham Heart Study, Framingham, MA 01702 5827, USA
Arterioscler Thromb Vasc Biol 26:1405-12. 2006..We undertook a linkage disequilibrium (LD)-based genetic approach to investigate the hypothesis that common sequence variants in 5 thrombosis genes influence plasma hemostatic protein levels or risk of cardiovascular disease (CVD)... - The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reportsL Adrienne Cupples
National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
BMC Med Genet 8:S1. 2007.... - Relations of long-term and contemporary lipid levels and lipid genetic risk scores with coronary artery calcium in the framingham heart studyConnie W Tsao
National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA 01702, USA
J Am Coll Cardiol 60:2364-71. 2012..This study evaluated the association of timing of lipid levels and lipid genetic risk score (GRS) with subclinical atherosclerosis... - Visceral and subcutaneous adipose tissue volumes are cross-sectionally related to markers of inflammation and oxidative stress: the Framingham Heart StudyKarla M Pou
Division of Endocrinology, Metabolism, and Diabetes, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass, USA
Circulation 116:1234-41. 2007..Excess adiposity is associated with greater systemic inflammation. Whether visceral adiposity is more proinflammatory than subcutaneous abdominal adiposity is unclear... - Common variants at 30 loci contribute to polygenic dyslipidemiaSekar Kathiresan
Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Nat Genet 41:56-65. 2009..These results suggest that the cumulative effect of multiple common variants contributes to polygenic dyslipidemia... - Assessment by cardiovascular magnetic resonance, electron beam computed tomography, and carotid ultrasonography of the distribution of subclinical atherosclerosis across Framingham risk strataSekar Kathiresan
Framingham Heart Study, Framingham, Massachusetts, USA
Am J Cardiol 99:310-4. 2007..In conclusion, in a community-based sample, correlations among subclinical atherosclerosis test results are low, and a substantial proportion has high levels of subclinical atherosclerosis detected on >or=2 imaging tests... - Comprehensive survey of common genetic variation at the plasminogen activator inhibitor-1 locus and relations to circulating plasminogen activator inhibitor-1 levelsSekar Kathiresan
National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts 01702 5827, USA
Circulation 112:1728-35. 2005.... - Cardiac troponin T elevation after coronary artery bypass grafting is associated with increased one-year mortalitySekar Kathiresan
Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Am J Cardiol 94:879-81. 2004.... - Heritability, linkage, and genetic associations of exercise treadmill test responsesErik Ingelsson
Framingham Study, Framingham, Mass, USA
Circulation 115:2917-24. 2007..The blood pressure (BP) and heart rate responses to exercise treadmill testing predict incidence of cardiovascular disease, but the genetic determinants of hemodynamic and chronotropic responses to exercise are largely unknown... - Genome-wide association study identifies eight loci associated with blood pressureChristopher Newton-Cheh
Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA
Nat Genet 41:666-76. 2009..These associations between common variants and blood pressure and hypertension offer mechanistic insights into the regulation of blood pressure and may point to novel targets for interventions to prevent cardiovascular disease... - Common genetic variation at the endothelial nitric oxide synthase locus and relations to brachial artery vasodilator function in the communitySekar Kathiresan
Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, MA, USA
Circulation 112:1419-27. 2005..Sequence variants at the endothelial nitric oxide synthase (NOS3) locus have been associated with endothelial function measures, but replication has been limited... - Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association dataRamachandran S Vasan
Framingham Heart Study, 73 Mt Wayte Ave, Ste 2, Framingham, MA 01702 5827, USA
JAMA 302:168-78. 2009..Echocardiographic measures of left ventricular (LV) structure and function are heritable phenotypes of cardiovascular disease... - Meta-analysis identifies six new susceptibility loci for atrial fibrillationPatrick T Ellinor
Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, Massachusetts, USA
Nat Genet 44:670-5. 2012..The identified loci implicate candidate genes that encode transcription factors related to cardiopulmonary development, cardiac-expressed ion channels and cell signaling molecules... - Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variantsSekar Kathiresan
Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Nat Genet 41:334-41. 2009..SNPs at nine loci were reproducibly associated with myocardial infarction, but tests of common and rare CNVs failed to identify additional associations with myocardial infarction risk... - Glycated albumin and direct low density lipoprotein cholesterol levels in type 2 diabetes mellitusMasumi Ai
Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
Clin Chim Acta 406:71-4. 2009.... - Association between glucokinase regulatory protein (GCKR) and apolipoprotein A5 (APOA5) gene polymorphisms and triacylglycerol concentrations in fasting, postprandial, and fenofibrate-treated statesPablo Perez-Martinez
Nutrition and Genomics Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
Am J Clin Nutr 89:391-9. 2009..Hypertriglyceridemia is a risk factor for cardiovascular disease. Variation in the apolipoprotein A5 (APOA5) and glucokinase regulatory protein (GCKR) genes has been associated with fasting plasma triacylglycerol... - Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulationJie Huang
National Heart, Lung, and Blood Institute NHBLI Framingham Heart Study, Framingham, MA 01702, USA
Blood 120:4873-81. 2012..1. In summary, SNPs in SERPINE1 and ARNTL and an SNP associated with the expression of MUC3 were robustly associated with circulating levels of PAI-1... - Genome-wide association study for coronary artery calcification with follow-up in myocardial infarctionChristopher J O'Donnell
MPH, NHLBI s Framingham Heart Study, 73 Mount Wayte Ave, Suite 2, Framingham, MA 01702, USA
Circulation 124:2855-64. 2011..We sought to identify common genetic variants associated with CAC and further investigate their associations with MI... - Increased small low-density lipoprotein particle number: a prominent feature of the metabolic syndrome in the Framingham Heart StudySekar Kathiresan
The National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA, USA
Circulation 113:20-9. 2006..Whereas increased small LDL particle number identified the MetSyn with high sensitivity, a higher small LDL particle number was not associated with greater CVD event rates in people with the MetSyn... - Genetics of coronary artery diseaseKiran Musunuru
Center for Human Genetic Research and Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02108, USA
Annu Rev Genomics Hum Genet 11:91-108. 2010..A key challenge now is to move from mapping loci to pinpointing causal genes and variants, and to develop a molecular understanding of how these genes lead to coronary disease... - Bayesian inference analyses of the polygenic architecture of rheumatoid arthritisEli A Stahl
Division of Rheumatology Immunology and Allergy, Brigham and Women s Hospital, Boston, Massachusetts, USA
Nat Genet 44:483-9. 2012..These analyses suggest that GWAS will continue to be highly productive for the discovery of additional susceptibility loci for common diseases... - Exome sequencing, ANGPTL3 mutations, and familial combined hypolipidemiaKiran Musunuru
Cardiovascular Research Center, Massachusetts General Hospital, and Department of Medicine, Boston University School of Public Health, Boston, MA 02114, USA
N Engl J Med 363:2220-7. 2010..Funded by the National Human Genome Research Institute and others.)... - Associations of long-term and early adult atherosclerosis risk factors with aortic and mitral valve calciumGeorge Thanassoulis
National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
J Am Coll Cardiol 55:2491-8. 2010..To determine the association of long-term exposure to atherosclerosis risk factors with valvular calcification... - Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathwaysNicole Soranzo
Human Genetics, Wellcome Trust Sanger Institute, Hinxton, U K
Diabetes 59:3229-39. 2010..We aimed to identify such genetic factors and investigate the extent to which they influence diabetes classification based on HbA₁(c) levels... - Non-invasive imaging of plaque vulnerability: an important tool for the assessment of agents to stabilise atherosclerotic plaquesDavid E Sosnovik
Division of Cardiology, CIMIT Massachusetts General Hospital, Boston, MA 02114, USA
Expert Opin Investig Drugs 11:693-704. 2002..This knowledge will be extremely important for physicians and scientists involved in the clinical evaluation of novel agents to stabilise the vulnerable plaque... - Exome sequencing and complex disease: practical aspects of rare variant association studiesRon Do
Center for Human Genetic Research and Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA
Hum Mol Genet 21:R1-9. 2012..Here, we provide practical guidance in the design and analysis of complex trait association studies focused on rare, coding variants... - Burden of rare sarcomere gene variants in the Framingham and Jackson Heart Study cohortsAlexander G Bick
Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
Am J Hum Genet 91:513-9. 2012..3) in the FHS cohort, suggesting that cardiovascular risk assessment in the general population can benefit from rare variant analysis... - Aging syndrome genes and premature coronary artery diseaseAdrian F Low
Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, and Harvard Medical School, Boston, MA, USA
BMC Med Genet 6:38. 2005..We evaluated whether common variants at the LMNA or KLOTHO genes are associated with rigorously defined premature CAD... - Testing for an unusual distribution of rare variantsBenjamin M Neale
The Center for Human Genetic Research, Massachusetts General Hospital, Boston, United States of America
PLoS Genet 7:e1001322. 2011..Through simulations and analysis of case/control data, we demonstrate good power relative to existing methods that assess the burden of rare variants in individuals... - Genetics of lipid disordersJames Pirruccello
Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Curr Opin Cardiol 25:238-42. 2010..In this review, we will highlight recent advances in identifying genes and gene regions responsible for the variation in serum lipid levels. We will also consider the next directions for research based on these advances... - Assessment of 2q23.1 microdeletion syndrome implicates MBD5 as a single causal locus of intellectual disability, epilepsy, and autism spectrum disorderMichael E Talkowski
Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
Am J Hum Genet 89:551-63. 2011.... - Increased plasma osteoprotegerin concentrations are associated with indices of bone strength of the hipElizabeth J Samelson
Institute for Aging Research, Hebrew SeniorLife, 1200 Centre Street, Boston, MA 02131, USA
J Clin Endocrinol Metab 93:1789-95. 2008..We conducted a cross-sectional study to evaluate the association between plasma OPG and femoral neck (FN) bone density (BMD) and geometry in a large cohort of women and men... - Off-pump coronary bypass grafting is associated with less myocardial injury than coronary bypass surgery with cardiopulmonary bypassSekar Kathiresan
Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts, USA
Heart Surg Forum 6:E174-8. 2003..CONCLUSIONS : The nearly 6-fold reduction of postoperative TnT associated with OPCAB suggests that off-pump surgery may offer superior cardioprotection than coronary artery bypass grafting with conventional cardiopulmonary bypass. \par.. - Case records of the Massachusetts General Hospital. Case 14-2005. A 38-year-old man with fever and blurred visionSekar Kathiresan
Cardiology Division, Department of Medicine, Massachusetts General Hospital, Boston, USA
N Engl J Med 352:2003-12. 2005 - Clinical and genetic correlates of serum aldosterone in the community: the Framingham Heart StudySekar Kathiresan
National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts 01702 5827, USA
Am J Hypertens 18:657-65. 2005..We investigated the environmental and genetic sources of interindividual variability in serum aldosterone level in a large, community-based sample... - New opportunities for identification and reduction of coronary risk: treatment of vulnerable patients, arteries, and plaquesJames E Muller
Harvard Medical School, Boston, Massachusetts, USA
J Am Coll Cardiol 47:C2-6. 2006..If vulnerable plaques and patients can be successfully identified and treated, there will be immense clinical benefits, accompanied by cost savings... - Clinician update: direct thrombin inhibitors in acute coronary syndromesJoanna J Wykrzykowska
Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
J Thromb Thrombolysis 15:47-57. 2003..As the knowledge of more appropriate use of these drugs progressed, there is a renewed interest in DTIs. Herein we will review the clinical studies assessing hirudin, bivalirudin and argatroban in the settings of AMI, UA and PCI... - A comparison of cardiac troponin T and creatine kinase-MB for patient evaluation after cardiac surgeryJames L Januzzi
Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
J Am Coll Cardiol 39:1518-23. 2002..CONCLUSIONS: Troponin T is superior to CK-MB for the prediction of impending complications after cardiac surgical procedures... - Vascular stiffness and genetic variation at the endothelial nitric oxide synthase locus: the Framingham Heart studyGary F Mitchell
Cardiovascular Engineering, Inc, Waltham, MA 02453, USA
Hypertension 49:1285-90. 2007..The present study was suggestive of modest relations between common genetic variants at the NOS3 locus and arterial stiffness... - Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levelsRicha Saxena
Broad Institute of Harvard and Massachusetts Institute of Technology MIT, Cambridge, MA 02142, USA
Science 316:1331-6. 2007..The discovery of associated variants in unsuspected genes and outside coding regions illustrates the ability of genome-wide association studies to provide potentially important clues to the pathogenesis of common diseases... - CCL2 polymorphisms are associated with serum monocyte chemoattractant protein-1 levels and myocardial infarction in the Framingham Heart StudyDavid H McDermott
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1886, USA
Circulation 112:1113-20. 2005..Monocyte chemoattractant protein-1 (MCP-1) is a chemokine strongly implicated in promoting atherosclerosis in animal models, but human genetic evidence is contradictory... - Bayesian meta-analysis of genetic association studies with different sets of markersClaudio Verzilli
Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
Am J Hum Genet 82:859-72. 2008..The same method could be applied to evidence synthesis of other quantitative traits, whenever the typed SNPs vary among studies, and to assist fine mapping of causal variants... - On the significance of linkage studies of complex traitsChristopher Newton-Cheh
Am J Hum Genet 75:151-2; author reply 152-4. 2004 - Algorithms for assessing cardiovascular risk in womenThomas J Wang
JAMA 298:176; author reply 177-8. 2007 - On the interpretation of genetic association studiesSekar Kathiresan
Eur Heart J 25:1378-81. 2004 - A PCSK9 missense variant associated with a reduced risk of early-onset myocardial infarctionSekar Kathiresan
N Engl J Med 358:2299-300. 2008
Research Grants
- Osteoprotegerin Pathway: Relations of Genes & Biomarkers to CVD in the CommunitySekar Kathiresan; Fiscal Year: 2007..In addition, the candidate will be well positioned to transition from conducting pathway-based investigation to genome-wide association studies for cardiovascular phenotypes. ..