Antoine E Karnoub

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. ncbi Ras oncogenes: split personalities
    Antoine E Karnoub
    Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Nat Rev Mol Cell Biol 9:517-31. 2008
  2. ncbi Mesenchymal stem cells within tumour stroma promote breast cancer metastasis
    Antoine E Karnoub
    Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Nature 449:557-63. 2007
  3. ncbi Transformation of different human breast epithelial cell types leads to distinct tumor phenotypes
    Tan A Ince
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA
    Cancer Cell 12:160-70. 2007
  4. ncbi Distinct requirements for Ras oncogenesis in human versus mouse cells
    Nesrin M Hamad
    Department of Pharmacology, Division of Neurology, Duke University Medical Center, Durham North Carolina 27710, USA
    Genes Dev 16:2045-57. 2002
  5. ncbi Vav transformation requires activation of multiple GTPases and regulation of gene expression
    Todd R Palmby
    Department of Pharmacology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, CB 7295, Chapel Hill, NC 27599 7295, USA
    Mol Cancer Res 2:702-11. 2004
  6. ncbi Auto-inhibition of the Dbl family protein Tim by an N-terminal helical motif
    Marielle E Yohe
    Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina 27599 7295, USA
    J Biol Chem 282:13813-23. 2007
  7. ncbi Rac1b, a tumor associated, constitutively active Rac1 splice variant, promotes cellular transformation
    Anurag Singh
    Department of Pharmacology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Oncogene 23:9369-80. 2004
  8. ncbi Molecular basis for Rho GTPase signaling specificity
    Antoine E Karnoub
    Department of Pharmacology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7295, USA
    Breast Cancer Res Treat 84:61-71. 2004
  9. ncbi Role of the pleckstrin homology domain in intersectin-L Dbl homology domain activation of Cdc42 and signaling
    Wendy M Pruitt
    Department of Pharmacology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7295, USA
    Biochim Biophys Acta 1640:61-8. 2003
  10. ncbi RhoG signals in parallel with Rac1 and Cdc42
    Krister Wennerberg
    Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599 7295, USA
    J Biol Chem 277:47810-7. 2002

Collaborators

  • Channing Der
  • Andrea L Richardson
  • Maki Saitoh
  • Andrew Sullivan
  • J N Rich
  • Robert Abraham
  • Robert Weinberg
  • Roopa Thapar
  • John Sondek
  • Todd R Palmby
  • Tan A Ince
  • Marielle E Yohe
  • Lee M Graves
  • Anurag Singh
  • Wendy M Pruitt
  • Krister Wennerberg
  • John M Lambert
  • Nesrin M Hamad
  • James D Iglehart
  • Olivia S Gardner
  • Svetlana Gershburg
  • George W Bell
  • Kent L Rossman
  • Jason T Snyder
  • Samuel Godar
  • Ernst Lengyel
  • Karon Abe
  • Stylianos E Antonarakis
  • Brian K Kay
  • A Corinne Rakauskas
  • David P Siderovski
  • Alexei Kurakin
  • Michel Guipponi
  • Christopher M Counter
  • Wenli Bai
  • Sharon L Campbell
  • Keith Burridge
  • Joel H Elconin
  • Rong Yu Liu
  • Rong-Yu Liu
  • Shawn M Ellerbroek

Detail Information

Publications12

  1. ncbi Ras oncogenes: split personalities
    Antoine E Karnoub
    Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Nat Rev Mol Cell Biol 9:517-31. 2008
    ....
  2. ncbi Mesenchymal stem cells within tumour stroma promote breast cancer metastasis
    Antoine E Karnoub
    Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Nature 449:557-63. 2007
    ..Collectively, these data demonstrate that the tumour microenvironment facilitates metastatic spread by eliciting reversible changes in the phenotype of cancer cells...
  3. ncbi Transformation of different human breast epithelial cell types leads to distinct tumor phenotypes
    Tan A Ince
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA
    Cancer Cell 12:160-70. 2007
    ..Hence, the pre-existing differences between BPECs and HMECs strongly influence the phenotypes of their transformed derivatives...
  4. ncbi Distinct requirements for Ras oncogenesis in human versus mouse cells
    Nesrin M Hamad
    Department of Pharmacology, Division of Neurology, Duke University Medical Center, Durham North Carolina 27710, USA
    Genes Dev 16:2045-57. 2002
    ..Thus, oncogenic Ras may transform murine and human cells by distinct mechanisms, and the RalGEF pathway--previously deemed to play a secondary role in Ras transformation--could represent a new target for anti-cancer therapy...
  5. ncbi Vav transformation requires activation of multiple GTPases and regulation of gene expression
    Todd R Palmby
    Department of Pharmacology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, CB 7295, Chapel Hill, NC 27599 7295, USA
    Mol Cancer Res 2:702-11. 2004
    ....
  6. ncbi Auto-inhibition of the Dbl family protein Tim by an N-terminal helical motif
    Marielle E Yohe
    Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina 27599 7295, USA
    J Biol Chem 282:13813-23. 2007
    ..Furthermore, substitutions within the most highly conserved surface of the DH domain designed to disrupt interactions with the auto-inhibitory helix also activate the exchange process...
  7. ncbi Rac1b, a tumor associated, constitutively active Rac1 splice variant, promotes cellular transformation
    Anurag Singh
    Department of Pharmacology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Oncogene 23:9369-80. 2004
    ..However, Rac1b did promote activation of the AKT serine/threonine kinase. Therefore, we suggest that Rac1b selectively activates a subset of Rac1 downstream signaling pathways to facilitate cellular transformation...
  8. ncbi Molecular basis for Rho GTPase signaling specificity
    Antoine E Karnoub
    Department of Pharmacology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7295, USA
    Breast Cancer Res Treat 84:61-71. 2004
    ..In this review, we highlight issues relating to the structural basis by which Dbl family GEFs facilitate signaling convergence and Rho GTPase activation, and how Rho GTPases promote signal dissemination through downstream effectors...
  9. ncbi Role of the pleckstrin homology domain in intersectin-L Dbl homology domain activation of Cdc42 and signaling
    Wendy M Pruitt
    Department of Pharmacology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7295, USA
    Biochim Biophys Acta 1640:61-8. 2003
    ..PH domains can interact with phosphoinositide substrates and products of phosphatidylinositol 3-kinase (PI3K). However, PI3K activation did not modulate ITSN-L DH domain function in vivo...
  10. ncbi RhoG signals in parallel with Rac1 and Cdc42
    Krister Wennerberg
    Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599 7295, USA
    J Biol Chem 277:47810-7. 2002
    ..Together, these data argue that RhoG function is mediated by signals independent of Rac1 and Cdc42 activation and instead by direct utilization of a subset of common effectors...
  11. ncbi Structural and biophysical insights into the role of the insert region in Rac1 function
    Roopa Thapar
    Department of Biochemistry and Biophysics, School of Medicine, and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Biochemistry 41:3875-83. 2002
    ....
  12. ncbi Role of MLK3-mediated activation of p70 S6 kinase in Rac1 transformation
    John M Lambert
    Lineberger Comprehensive Cancer Center, Department of Pharmacology and Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, North Carolina 27599 7295, USA
    J Biol Chem 277:4770-7. 2002
    ..These results suggest that MLK3 may be a negative regulator of the growth-promoting and transforming properties of Rac1...