Elizabeth Karlson

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. doi request reprint Epidemiology: Interpreting studies of interactions between RA risk factors
    Elizabeth W Karlson
    Section of Clinical Sciences, Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Nat Rev Rheumatol 6:72-3. 2010
  2. pmc Association of environmental and genetic factors and gene-environment interactions with risk of developing rheumatoid arthritis
    Elizabeth W Karlson
    Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Arthritis Care Res (Hoboken) 65:1147-56. 2013
  3. pmc Environmental and gene-environment interactions and risk of rheumatoid arthritis
    Elizabeth W Karlson
    Section of Clinical Sciences, Division of Rheumatology, Allergy and Immunology, Department of Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Rheum Dis Clin North Am 38:405-26. 2012
  4. pmc Genetic polymorphisms in PTPN22, PADI-4, and CTLA-4 and risk for rheumatoid arthritis in two longitudinal cohort studies: evidence of gene-environment interactions with heavy cigarette smoking
    Karen H Costenbader
    Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Arthritis Res Ther 10:R52. 2008
  5. pmc Epstein-Barr virus and rheumatoid arthritis: is there a link?
    Karen H Costenbader
    Brigham and Women s Hospital, Division of Rheumatology, Immunology and Allergy, Department of Medicine, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Arthritis Res Ther 8:204. 2006
  6. pmc The relationship between disease activity, sleep, psychiatric distress and pain sensitivity in rheumatoid arthritis: a cross-sectional study
    Yvonne C Lee
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, 75 Francis Street, PBB B3, Boston, MA 02115, USA
    Arthritis Res Ther 11:R160. 2009
  7. pmc Protein, iron, and meat consumption and risk for rheumatoid arthritis: a prospective cohort study
    Elizabeth Benito-Garcia
    Section of Clinical Sciences, Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women s Hospital, Francis Street, Boston, Massachusetts 02115, USA
    Arthritis Res Ther 9:R16. 2007
  8. ncbi request reprint Serologic evaluations of women exposed to breast implants
    E W Karlson
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Rheumatol 28:1523-30. 2001
  9. pmc Gene-environment interaction between HLA-DRB1 shared epitope and heavy cigarette smoking in predicting incident rheumatoid arthritis
    E W Karlson
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, Massachusetts 02115, USA
    Ann Rheum Dis 69:54-60. 2010
  10. pmc Vitamin E in the primary prevention of rheumatoid arthritis: the Women's Health Study
    Elizabeth W Karlson
    Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Arthritis Rheum 59:1589-95. 2008

Research Grants

  1. ANTIOXIDANTS AND FEMALE HORMONES IN THE ETIOLOGY OF RA
    Elizabeth Karlson; Fiscal Year: 2002
  2. Clinical Risk Prediction Modeling in Rheumatoid Arthritis
    Elizabeth Karlson; Fiscal Year: 2009
  3. Hormone, cytokine, and genetic risks for RA in women
    Elizabeth Karlson; Fiscal Year: 2007
  4. Genetic Predictors of Early Atherosclerosis in SLE
    Elizabeth Karlson; Fiscal Year: 2007
  5. Clinical Risk Prediction Modeling in Rheumatoid Arthritis
    Elizabeth W Karlson; Fiscal Year: 2010

Detail Information

Publications67

  1. doi request reprint Epidemiology: Interpreting studies of interactions between RA risk factors
    Elizabeth W Karlson
    Section of Clinical Sciences, Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Nat Rev Rheumatol 6:72-3. 2010
    ..As recent epidemiological evidence shows, deciphering these interactions demands consideration of the analytical approach used...
  2. pmc Association of environmental and genetic factors and gene-environment interactions with risk of developing rheumatoid arthritis
    Elizabeth W Karlson
    Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Arthritis Care Res (Hoboken) 65:1147-56. 2013
    ..We developed rheumatoid arthritis (RA) risk models based on validated environmental factors (E), genetic risk scores (GRS), and gene-environment interactions (GEI) to identify factors that can improve accuracy and reclassification...
  3. pmc Environmental and gene-environment interactions and risk of rheumatoid arthritis
    Elizabeth W Karlson
    Section of Clinical Sciences, Division of Rheumatology, Allergy and Immunology, Department of Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Rheum Dis Clin North Am 38:405-26. 2012
    ..This article reviews these factors and interactions, especially those that have been investigated in a prospective fashion before the symptomatic onset of RA...
  4. pmc Genetic polymorphisms in PTPN22, PADI-4, and CTLA-4 and risk for rheumatoid arthritis in two longitudinal cohort studies: evidence of gene-environment interactions with heavy cigarette smoking
    Karen H Costenbader
    Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Arthritis Res Ther 10:R52. 2008
    ..We investigated whether polymorphisms in these genes were associated with RA in Caucasian women included in two large prospective cohorts, adjusting for confounding factors and testing for interactions with smoking...
  5. pmc Epstein-Barr virus and rheumatoid arthritis: is there a link?
    Karen H Costenbader
    Brigham and Women s Hospital, Division of Rheumatology, Immunology and Allergy, Department of Medicine, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Arthritis Res Ther 8:204. 2006
    ..In latent and replicating forms, it has immunomodulating actions that could play a role in the development of this autoimmune disease. The evidence linking Epstein-Barr virus and rheumatoid arthritis is reviewed...
  6. pmc The relationship between disease activity, sleep, psychiatric distress and pain sensitivity in rheumatoid arthritis: a cross-sectional study
    Yvonne C Lee
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, 75 Francis Street, PBB B3, Boston, MA 02115, USA
    Arthritis Res Ther 11:R160. 2009
    ..The etiology of RA pain is likely multifactorial, including both inflammatory and non-inflammatory components. In this study, we examine the association between disease activity, sleep, psychiatric distress and pain sensitivity in RA...
  7. pmc Protein, iron, and meat consumption and risk for rheumatoid arthritis: a prospective cohort study
    Elizabeth Benito-Garcia
    Section of Clinical Sciences, Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women s Hospital, Francis Street, Boston, Massachusetts 02115, USA
    Arthritis Res Ther 9:R16. 2007
    ..We were unable to confirm that there is an association between protein or meat and risk for RA in this large female cohort. Iron was also not associated with RA in this cohort...
  8. ncbi request reprint Serologic evaluations of women exposed to breast implants
    E W Karlson
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Rheumatol 28:1523-30. 2001
    ..We conducted laboratory tests in a large number of women with and without breast implants, and in diabetic patients with presumed silicone exposure via insulin syringes...
  9. pmc Gene-environment interaction between HLA-DRB1 shared epitope and heavy cigarette smoking in predicting incident rheumatoid arthritis
    E W Karlson
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, Massachusetts 02115, USA
    Ann Rheum Dis 69:54-60. 2010
    ..To address the effect of dosage, a case-control study nested within two prospective cohorts to determine the interaction between heavy smoking and the HLA-SE was conducted...
  10. pmc Vitamin E in the primary prevention of rheumatoid arthritis: the Women's Health Study
    Elizabeth W Karlson
    Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Arthritis Rheum 59:1589-95. 2008
    ..Vitamin E supplements may reduce the risk of developing rheumatoid arthritis (RA) through antioxidant effects. Although previous observational studies have investigated this question, no randomized trial data are available...
  11. ncbi request reprint High sensitivity, specificity and predictive value of the Connective Tissue Disease Screening Questionnaire among urban African-American women
    E W Karlson
    Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Lupus 14:832-6. 2005
    ..These results suggest that the CSQ has adequate sensitivity and specificity and could be used in population studies to screen African-American women for SLE...
  12. pmc Associations between human leukocyte antigen, PTPN22, CTLA4 genotypes and rheumatoid arthritis phenotypes of autoantibody status, age at diagnosis and erosions in a large cohort study
    E W Karlson
    Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Ann Rheum Dis 67:358-63. 2008
    ..HLA-DRB1 shared epitope (HLA-SE), PTPN22 and CTLA4 alleles are associated with cyclic citrullinated peptide (CCP) and rheumatoid arthritis (RA)...
  13. pmc Biomarkers of inflammation and development of rheumatoid arthritis in women from two prospective cohort studies
    Elizabeth W Karlson
    Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Arthritis Rheum 60:641-52. 2009
    ..To examine the association of biomarkers of inflammation with preclinical rheumatoid arthritis (RA)...
  14. ncbi request reprint Do breast-feeding and other reproductive factors influence future risk of rheumatoid arthritis? Results from the Nurses' Health Study
    Elizabeth W Karlson
    Brigham and Women s Hospital, Harvard Medical School, and Harvard School of Public Health, 75 Francis Street, Boston, MA 02115, USA
    Arthritis Rheum 50:3458-67. 2004
    ....
  15. ncbi request reprint Effect of glutathione S-transferase polymorphisms and proximity to hazardous waste sites on time to systemic lupus erythematosus diagnosis: results from the Roxbury lupus project
    Elizabeth W Karlson
    Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Arthritis Rheum 56:244-54. 2007
    ..Our goal was to assess association of residential proximity to hazardous waste sites and genetic variation in 3 glutathione Stransferase (GST) genes (GSTM1, GSTT1, and GSTP1) with age at diagnosis of SLE...
  16. pmc Cumulative association of 22 genetic variants with seropositive rheumatoid arthritis risk
    Elizabeth W Karlson
    75 Francis Street, Boston, MA 02115, USA
    Ann Rheum Dis 69:1077-85. 2010
    ..This study examined whether a cumulative score based on 22 validated genetic risk alleles for seropositive RA would identify high-risk, asymptomatic individuals who might benefit from preventive interventions...
  17. ncbi request reprint Total hip replacement due to osteoarthritis: the importance of age, obesity, and other modifiable risk factors
    Elizabeth W Karlson
    Division of Rheumatology, Immunology, and Allergy, Robert B Brigham Arthritis and Musculoskeletal Diseases Clinical Research Center, Boston, Massachusetts, USA
    Am J Med 114:93-8. 2003
    ..In the Nurses' Health Study, higher body mass index and older age significantly increased the risk of total hip replacement due to osteoarthritis. Part of this risk appeared to be established early in life...
  18. ncbi request reprint Coffee consumption and risk of rheumatoid arthritis
    Elizabeth W Karlson
    Harvard Medical School, and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Arthritis Rheum 48:3055-60. 2003
    ..We studied whether coffee, decaffeinated coffee, total coffee, tea, or overall caffeine consumption was associated with the risk of RA, using the Nurses' Health Study, a longitudinal cohort study of 121,701 women...
  19. pmc A prospective study of androgen levels, hormone-related genes and risk of rheumatoid arthritis
    Elizabeth W Karlson
    Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Arthritis Res Ther 11:R97. 2009
    ....
  20. ncbi request reprint A randomized clinical trial of a psychoeducational intervention to improve outcomes in systemic lupus erythematosus
    Elizabeth W Karlson
    Brigham and Women s Hospital, and Robert B Brigham Arthritis and Musculoskeletal Diseases Clinical Research Center, Boston, Massachusetts 02115, USA
    Arthritis Rheum 50:1832-41. 2004
    ..The goal of this study was to evaluate in a randomized controlled trial a theory-based intervention to improve patient self-efficacy and partner support to manage SLE...
  21. pmc Integration of genetic risk factors into a clinical algorithm for multiple sclerosis susceptibility: a weighted genetic risk score
    Philip L De Jager
    Program in Translational NeuroPsychiatric Genomics, Department of Neurology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Lancet Neurol 8:1111-9. 2009
    ..We investigated the usefulness of an aggregate measure of risk of MS that is based on genetic susceptibility loci. We also assessed the added effect of environmental risk factors that are associated with susceptibility for MS...
  22. ncbi request reprint Antioxidants and other novel cardiovascular risk factors in subjects with rheumatoid arthritis in a large population sample
    Paola de Pablo
    Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Arthritis Rheum 57:953-62. 2007
    ..To compare antioxidants and other novel and traditional cardiovascular disease (CVD) risk factors in participants with rheumatoid arthritis (RA) and non-RA controls in a large population sample...
  23. pmc Environmental influences on risk for rheumatoid arthritis
    Katherine P Liao
    Brigham and Women s Hospital, Boston, Massachusetts 02141, USA
    Curr Opin Rheumatol 21:279-83. 2009
    ..This review is timely given the expanding information on treatment, pathogenesis and genetic risk factors for RA...
  24. pmc Genetic basis of autoantibody positive and negative rheumatoid arthritis risk in a multi-ethnic cohort derived from electronic health records
    Fina Kurreeman
    Division of Rheumatology, Immunology, and Allergy and Division of Genetics, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts 02142, USA
    Am J Hum Genet 88:57-69. 2011
    ....
  25. ncbi request reprint Factors determining participation in prevention trials among systemic lupus erythematosus patients: a qualitative study
    Karen H Costenbader
    Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Arthritis Rheum 57:49-55. 2007
    ..Our goal was to determine factors that patients with SLE consider in deciding about participating in prevention trials, to uncover concerns about SLE trials, and to investigate how study design and purpose affect participation decisions...
  26. pmc Alcohol consumption and markers of inflammation in women with preclinical rheumatoid arthritis
    Bing Lu
    Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Arthritis Rheum 62:3554-9. 2010
    ..To examine the association between alcohol consumption and markers of inflammation in preclinical rheumatoid arthritis (RA)...
  27. pmc Genome-wide association study of determinants of anti-cyclic citrullinated peptide antibody titer in adults with rheumatoid arthritis
    Jing Cui
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Med 15:136-43. 2009
    ..We identified a SNP in moderate linkage disequilibrium (LD) with HLA-DR3, which may influence anti-CCP titer independently of the HLA-SE...
  28. ncbi request reprint Cardiovascular risk factors in women with and without rheumatoid arthritis
    Daniel H Solomon
    Division of Pharmacoepidemiology, Brigham and Women s Hospital, Harvard Medical School, 1620 Tremont Street, Boston, MA 02120, USA
    Arthritis Rheum 50:3444-9. 2004
    ..The risk of cardiovascular disease (CVD) is increased in patients with rheumatoid arthritis (RA). The objective of this study was to examine the distribution of known CVD risk factors and biomarkers of CVD in women with and without RA...
  29. pmc The PRL -1149 G/T polymorphism and rheumatoid arthritis susceptibility
    Yvonne C Lee
    Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Arthritis Rheum 60:1250-4. 2009
    ..The aim of this study was to determine the role of the PRL -1149 G/T polymorphism (rs1341239) in rheumatoid arthritis (RA) susceptibility...
  30. ncbi request reprint Cardiovascular care and cancer screening in female nurses with and without rheumatoid arthritis
    Daniel H Solomon
    Division of Pharmacoepidemiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02120, USA
    Arthritis Rheum 51:429-32. 2004
    ..To compare frequencies of cancer screening and cardiovascular treatments aimed at reducing acute myocardial infarction in women with and without rheumatoid arthritis (RA)...
  31. pmc Systemic lupus erythematosus and the risk of cardiovascular disease: results from the nurses' health study
    A Elisabeth Hak
    Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Arthritis Rheum 61:1396-402. 2009
    ..Systemic lupus erythematosus (SLE) has been associated with an increased risk of cardiovascular disease. However, prospective population-based data addressing this association have been lacking...
  32. ncbi request reprint Alcohol intake and risk of incident gout in men: a prospective study
    Hyon K Choi
    Rheumatology Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Lancet 363:1277-81. 2004
    ..Additionally, potential differences in risk of gout posed by different alcoholic beverages have not been assessed...
  33. ncbi request reprint Purine-rich foods, dairy and protein intake, and the risk of gout in men
    Hyon K Choi
    Rheumatology Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    N Engl J Med 350:1093-103. 2004
    ..Similarly, the possibility that the consumption of dairy products has a role in protecting against gout has been raised by metabolic studies. We prospectively investigated the association of these dietary factors with new cases of gout...
  34. pmc Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk
    Soumya Raychaudhuri
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Nat Genet 41:1313-8. 2009
    ..0008 replication, P = 4 x 10(-6) overall) and FCGR2A (rs12746613, P = 0.0022 replication, P = 2 x 10(-5) overall). Many of these loci are also associated to other immunologic diseases...
  35. ncbi request reprint Cardiovascular morbidity and mortality in women diagnosed with rheumatoid arthritis
    Daniel H Solomon
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Circulation 107:1303-7. 2003
    ..Rheumatoid arthritis may be associated with an increased risk of cardiovascular disease. We compared the incidence rates of myocardial infarction and stroke in subjects with and without rheumatoid arthritis...
  36. pmc Low-dose aspirin in the primary prevention of rheumatoid arthritis: the Women's Health Study
    Nancy A Shadick
    Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Arthritis Care Res (Hoboken) 62:545-50. 2010
    ..Previous randomized trial data have demonstrated a beneficial effect of low-dose aspirin in reducing other inflammatory diseases, such as asthma and colorectal adenomas, but no trial has evaluated the role of aspirin in RA prevention...
  37. pmc Rheumatoid arthritis risk allele PTPRC is also associated with response to anti-tumor necrosis factor alpha therapy
    Jing Cui
    Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Arthritis Rheum 62:1849-61. 2010
    ..The aim of the present study was to test established RA genetic risk factors to determine whether the same alleles also influence the response to anti-TNF therapy...
  38. ncbi request reprint Cigarette smoking and the risk of systemic lupus erythematosus: a meta-analysis
    Karen H Costenbader
    Robert B Brigham Arthritis and Musculoskeletal Diseases Clinical Research Center, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Arthritis Rheum 50:849-57. 2004
    ..We performed an extensive search of the medical literature for all studies examining this relationship, and performed a meta-analysis to arrive at a more precise estimate of effect...
  39. pmc Antioxidant intake and risks of rheumatoid arthritis and systemic lupus erythematosus in women
    Karen H Costenbader
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Epidemiol 172:205-16. 2010
    ..In these large, prospective cohorts of women, antioxidant intake was not associated with the risk of developing either rheumatoid arthritis or systemic lupus erythematosus...
  40. pmc Effect of interactions of glutathione S-transferase T1, M1, and P1 and HMOX1 gene promoter polymorphisms with heavy smoking on the risk of rheumatoid arthritis
    Brendan T Keenan
    Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Arthritis Rheum 62:3196-210. 2010
    ..This study was undertaken to examine the impact of gene-smoking interactions on susceptibility to rheumatoid arthritis (RA)...
  41. ncbi request reprint Cardiac risk factor awareness and management in patients with systemic lupus erythematosus
    Karen H Costenbader
    Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts 02115, USA
    Arthritis Rheum 51:983-8. 2004
    ..To assess awareness and management of traditional cardiac risk factors (CRFs) in patients with systemic lupus erythematosus (SLE) and physicians...
  42. pmc Specific association of type 1 diabetes mellitus with anti-cyclic citrullinated peptide-positive rheumatoid arthritis
    Katherine P Liao
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Boston, MA 02114, USA
    Arthritis Rheum 60:653-60. 2009
    ..In this study, the strength and nature of this association were investigated at the population level in a Swedish case-control cohort...
  43. ncbi request reprint Smoking intensity, duration, and cessation, and the risk of rheumatoid arthritis in women
    Karen H Costenbader
    Division of Rheumatology, Immunology, and Allergy, Robert B Brigham Arthritis and Musculoskeletal Diseases Clinical Research Center, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Am J Med 119:503.e1-9. 2006
    ....
  44. pmc Two independent alleles at 6q23 associated with risk of rheumatoid arthritis
    Robert M Plenge
    Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Nat Genet 39:1477-82. 2007
    ..We show that these two SNP associations are statistically independent, are each reproducible in the comparison of our data and WTCCC data, and define risk and protective haplotypes for rheumatoid arthritis at 6q23...
  45. ncbi request reprint Cigarette smoking and systemic lupus erythematosus: a smoking gun?
    Karen H Costenbader
    Brigham and Women s Hospital, Division of Rheumatology, Immunology and Allergy, Department of Medicine, Boston, MA 02115, USA
    Autoimmunity 38:541-7. 2005
    ..5 [95% CI 1.09, 2.08]), but no increased risk associated with past smoking. The strengths and weaknesses of these data and potential implications are discussed...
  46. pmc Perinatal factors and adult-onset lupus
    Julia F Simard
    Department of Epidemiology, Harvard University School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Arthritis Rheum 59:1155-61. 2008
    ..Therefore, we evaluated the role of birth weight, being breastfed, and preterm birth on the incidence of SLE in participants in the Nurses' Health Study (NHS) and the Nurses' Health Study II (NHSII)...
  47. ncbi request reprint A pravastatin dose-escalation study in systemic lupus erythematosus
    Karen H Costenbader
    Division of Rheumatology, Immunology, and Allergy, Section of Clinical Sciences, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
    Rheumatol Int 27:1071-7. 2007
    ..Pravastatin reduced LDL and total cholesterol levels approximately the same degree observed in normal individuals, but the effect appeared blunted in those on modest doses of glucocorticoids and those with higher BMI...
  48. pmc Geographic variation in rheumatoid arthritis incidence among women in the United States
    Karen H Costenbader
    Section of Clinical Sciences, Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    Arch Intern Med 168:1664-70. 2008
    ..The geographic variation in rheumatoid arthritis (RA) incidence in the United States is unknown...
  49. ncbi request reprint C-reactive protein in the prediction of rheumatoid arthritis in women
    Nancy A Shadick
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Arch Intern Med 166:2490-4. 2006
    ..The purpose of this study was to examine whether levels of C-reactive protein (CRP), a sensitive marker of disease activity in rheumatoid arthritis (RA), are associated with increased risk of subsequent RA...
  50. ncbi request reprint Barriers to a trial of atherosclerosis prevention in systemic lupus erythematosus
    Karen H Costenbader
    Brigham and Women s Hospital, Boston, MA 02115, USA
    Arthritis Rheum 53:718-23. 2005
    ..We describe our experience in recruiting and retaining patients with SLE in this trial...
  51. ncbi request reprint Obesity, weight change, hypertension, diuretic use, and risk of gout in men: the health professionals follow-up study
    Hyon K Choi
    Rheumatology Unit, Department of Medicine, Massachusetts General Hospital, MA 02114, USA
    Arch Intern Med 165:742-8. 2005
    ..Similarly, both hypertension and diuretic use have been considered risk factors for gout; however, their independent contributions have not been established prospectively...
  52. pmc Investigation of candidate polymorphisms and disease activity in rheumatoid arthritis patients on methotrexate
    Yvonne C Lee
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Rheumatology (Oxford) 48:613-7. 2009
    ..We examined the association between candidate single nucleotide polymorphisms (SNPs) and disease activity in RA patients on MTX...
  53. ncbi request reprint Reproductive and menopausal factors and risk of systemic lupus erythematosus in women
    Karen H Costenbader
    Robert B Brigham Arthritis and Musculoskeletal Diseases Clinical Research Center, Brigham and Women s Hospital, and Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Arthritis Rheum 56:1251-62. 2007
    ..This study was carried out to examine associations between female reproductive and menopausal factors and the development of SLE...
  54. pmc Atherosclerotic vascular disease in systemic lupus erythematosus
    Matthew H Liang
    Department of Medicine, Robert B Brigham Arthritis and Musculoskeletal Diseases Clinical Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, USA
    J Natl Med Assoc 94:813-9. 2002
    ..The study of the best and most effective means to prevent ASVD in SLE and in African Americans with SLE and in African Americans with SLE should be a major priority...
  55. doi request reprint Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci
    Eli A Stahl
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Nat Genet 42:508-14. 2010
    ..An additional 11 SNPs replicated at P < 0.05, many of which are validated autoimmune risk alleles, suggesting that most represent genuine rheumatoid arthritis risk alleles...
  56. ncbi request reprint Occupational silica and solvent exposures and risk of systemic lupus erythematosus in urban women
    Axel Finckh
    Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Arthritis Rheum 54:3648-54. 2006
    ..To assess the risk of systemic lupus erythematosus (SLE) associated with occupational exposure to silica dust and organic solvents in an urban population...
  57. pmc Comparison of threshold cutpoints and continuous measures of anti-cyclic citrullinated peptide antibodies in predicting future rheumatoid arthritis
    Lori B Chibnik
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
    J Rheumatol 36:706-11. 2009
    ..While the anti-CCP level is commonly dichotomized for clinical use, the best threshold for and utility of the titer as a continuous variable to predict development of RA are uncertain...
  58. pmc Early life factors and adult-onset rheumatoid arthritis
    Julia F Simard
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    J Rheumatol 37:32-7. 2010
    ..We investigated the association of preterm birth and being breastfed with the incidence of rheumatoid arthritis (RA) in 2 large prospective cohorts...
  59. pmc Expression of CD44 variant isoforms CD44v3 and CD44v6 is increased on T cells from patients with systemic lupus erythematosus and is correlated with disease activity
    Jose C Crispin
    Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
    Arthritis Rheum 62:1431-7. 2010
    ....
  60. pmc Exposure to traffic pollution and increased risk of rheumatoid arthritis
    Jaime E Hart
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Environ Health Perspect 117:1065-9. 2009
    ..Particulate air pollution, especially of traffic origin, has been linked to systemic inflammation in many studies...
  61. pmc Electronic medical records for discovery research in rheumatoid arthritis
    Katherine P Liao
    Brigham and Women s Hospital, Boston, Massachusetts, USA
    Arthritis Care Res (Hoboken) 62:1120-7. 2010
    ..We assessed whether a classification algorithm incorporating narrative EMR data (typed physician notes) more accurately classifies subjects with rheumatoid arthritis (RA) compared with an algorithm using codified EMR data alone...
  62. ncbi request reprint Experience with etanercept in an academic medical center: are infection rates increased?
    Kristine Phillips
    Robert B Brigham Multipurpose Arthritis and Musculoskeletal Diseases Center, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Arthritis Rheum 47:17-21. 2002
    ..Reduction of concomitant corticosteroid and disease-modifying antirheumatic drug was also assessed...
  63. pmc Development and initial validation of a self-assessed lupus organ damage instrument
    Karen H Costenbader
    Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts
    Arthritis Care Res (Hoboken) 62:559-68. 2010
    ..Trained physicians must complete it, thus limiting utility where this is impossible...
  64. ncbi request reprint Defining lupus cases for clinical studies: the Boston weighted criteria for the classification of systemic lupus erythematosus
    Karen H Costenbader
    Robert B Brigham Arthritis and Musculoskeletal Disease Clinical Research Center, Boston, Massachusetts, USA
    J Rheumatol 29:2545-50. 2002
    ..We developed and evaluated the ability of a weighted classification system to identify a broader spectrum of patients with lupus...
  65. pmc Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4
    Robert M Plenge
    Broad Institute of MIT and Harvard, Cambridge, MA, USA
    Am J Hum Genet 77:1044-60. 2005
    ....
  66. pmc Common variants at CD40 and other loci confer risk of rheumatoid arthritis
    Soumya Raychaudhuri
    Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Nat Genet 40:1216-23. 2008
    ..1 x 10(-7) overall), CDK6 (rs42041, P = 0.010 replication, P = 4.0 x 10(-6) overall), PRKCQ (rs4750316, P = 0.0078 replication, P = 4.4 x 10(-6) overall), and KIF5A-PIP4K2C (rs1678542, P = 0.0026 replication, P = 8.8 x 10(-8) overall)...
  67. ncbi request reprint Interaction between smoking, the shared epitope, and anti-cyclic citrullinated peptide: a mixed picture in three large North American rheumatoid arthritis cohorts
    Hye Soon Lee
    Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, New York 11030, USA
    Arthritis Rheum 56:1745-53. 2007
    ..In an effort to confirm this interaction between smoking and shared epitope alleles, we performed a case-only analysis of 3 North American RA cohorts...

Research Grants11

  1. ANTIOXIDANTS AND FEMALE HORMONES IN THE ETIOLOGY OF RA
    Elizabeth Karlson; Fiscal Year: 2002
    ..RA will be confirmed by a screening questionnaire regarding rheumatic symptoms and review of medical records. The study will identify potentially modifiable risk factors for primary prevention of RA. ..
  2. Clinical Risk Prediction Modeling in Rheumatoid Arthritis
    Elizabeth Karlson; Fiscal Year: 2009
    ..This information will be used to develop personally tailored physical activity counseling to promote health and reduce cardiovascular risk of patients with RA. ..
  3. Hormone, cytokine, and genetic risks for RA in women
    Elizabeth Karlson; Fiscal Year: 2007
    ..Ultimately, this study could lead to the identification of potential targets for therapeutic interventions to treat RA or to reduce the risk of this serious autoimmune disease. ..
  4. Genetic Predictors of Early Atherosclerosis in SLE
    Elizabeth Karlson; Fiscal Year: 2007
    ..abstract_text> ..
  5. Clinical Risk Prediction Modeling in Rheumatoid Arthritis
    Elizabeth W Karlson; Fiscal Year: 2010
    ..This information will be used to develop personally tailored physical activity counseling to promote health and reduce cardiovascular risk of patients with RA. ..