Roger Kamm

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. pmc Migration of tumor cells in 3D matrices is governed by matrix stiffness along with cell-matrix adhesion and proteolysis
    Muhammad H Zaman
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 103:10889-94. 2006
  2. ncbi request reprint Cytoskeletal remodeling and cellular activation during deformation of neutrophils into narrow channels
    Belinda Yap
    Harvard Massachusetts Institute of Technology Division of Health Sciences and Technology, Cambridge, MA 02139, USA
    J Appl Physiol 99:2323-30. 2005
  3. pmc Computational analysis of viscoelastic properties of crosslinked actin networks
    Taeyoon Kim
    Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    PLoS Comput Biol 5:e1000439. 2009
  4. pmc Engineering of in vitro 3D capillary beds by self-directed angiogenic sprouting
    Juliana M Chan
    Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
    PLoS ONE 7:e50582. 2012
  5. pmc In vitro model of tumor cell extravasation
    Jessie S Jeon
    Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA
    PLoS ONE 8:e56910. 2013
  6. pmc Dynamic mechanisms of cell rigidity sensing: insights from a computational model of actomyosin networks
    Carlos Borau
    Aragon Institute of Engineering Research I3A, Department of Mechanical Engineering, University of Zaragoza, Zaragoza, Spain
    PLoS ONE 7:e49174. 2012
  7. ncbi request reprint Generation of 3D functional microvascular networks with human mesenchymal stem cells in microfluidic systems
    Jessie S Jeon
    Department of Mechanical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, USA 02139
    Integr Biol (Camb) 6:555-63. 2014
  8. doi request reprint Creating living cellular machines
    Roger D Kamm
    Massachusetts Institute of Technology, Cambridge, MA, USA
    Ann Biomed Eng 42:445-59. 2014
  9. pmc Mechanisms of tumor cell extravasation in an in vitro microvascular network platform
    Michelle B Chen
    Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA
    Integr Biol (Camb) 5:1262-71. 2013
  10. ncbi request reprint On the molecular basis for mechanotransduction
    Roger D Kamm
    Department of Mechanical Engineering and Biological Engineering Division, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Mech Chem Biosyst 1:201-9. 2004

Collaborators

Detail Information

Publications59

  1. pmc Migration of tumor cells in 3D matrices is governed by matrix stiffness along with cell-matrix adhesion and proteolysis
    Muhammad H Zaman
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 103:10889-94. 2006
    ..Our experimental findings here represent, to our knowledge, discovery of a previously undescribed set of balances of cell and matrix properties that govern the ability of tumor cells to migration in 3D environments...
  2. ncbi request reprint Cytoskeletal remodeling and cellular activation during deformation of neutrophils into narrow channels
    Belinda Yap
    Harvard Massachusetts Institute of Technology Division of Health Sciences and Technology, Cambridge, MA 02139, USA
    J Appl Physiol 99:2323-30. 2005
    ..These observations show that mechanical deformation of neutrophils into narrow pulmonary capillaries have the ability to influence cytoskeletal structure, the degree of cellular activation, and migrational tendencies of the cells...
  3. pmc Computational analysis of viscoelastic properties of crosslinked actin networks
    Taeyoon Kim
    Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    PLoS Comput Biol 5:e1000439. 2009
    ..Taken together, our results suggest that viscoelasticity of the actin network is attributable to different mechanisms depending on the amount of prestrain...
  4. pmc Engineering of in vitro 3D capillary beds by self-directed angiogenic sprouting
    Juliana M Chan
    Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
    PLoS ONE 7:e50582. 2012
    ..This laboratory-constructed vascular supply may be clinically significant for the engineering of capillary beds and higher order biological tissues in a scalable and modular manner...
  5. pmc In vitro model of tumor cell extravasation
    Jessie S Jeon
    Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA
    PLoS ONE 8:e56910. 2013
    ..The percent of tumor cells extravasated remained nearly constant from1 to 3 days after tumor seeding, indicating extravasation in our system generally occurs within the first 24 hours of tumor cell contact with the endothelium...
  6. pmc Dynamic mechanisms of cell rigidity sensing: insights from a computational model of actomyosin networks
    Carlos Borau
    Aragon Institute of Engineering Research I3A, Department of Mechanical Engineering, University of Zaragoza, Zaragoza, Spain
    PLoS ONE 7:e49174. 2012
    ..Therefore, this study provides new insights into the role of molecular motors in the contraction and rigidity sensing of cells...
  7. ncbi request reprint Generation of 3D functional microvascular networks with human mesenchymal stem cells in microfluidic systems
    Jessie S Jeon
    Department of Mechanical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, USA 02139
    Integr Biol (Camb) 6:555-63. 2014
    ..This system has promising applications in the development of advanced in vitro models to study complex biological phenomena involving functional and perfusable microvascular networks. ..
  8. doi request reprint Creating living cellular machines
    Roger D Kamm
    Massachusetts Institute of Technology, Cambridge, MA, USA
    Ann Biomed Eng 42:445-59. 2014
    ..Future prospects as well as ways of addressing these complex ethical questions will be discussed. ..
  9. pmc Mechanisms of tumor cell extravasation in an in vitro microvascular network platform
    Michelle B Chen
    Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA
    Integr Biol (Camb) 5:1262-71. 2013
    ..Tumor transendothelial migration efficiency is significantly higher in trapped cells compared to non-trapped adhered cells, and in cell clusters versus single tumor cells...
  10. ncbi request reprint On the molecular basis for mechanotransduction
    Roger D Kamm
    Department of Mechanical Engineering and Biological Engineering Division, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Mech Chem Biosyst 1:201-9. 2004
    ..One example is presented showing how the binding affinity between the focal adhesion targeting domain of focal adhesion kinase and the LD motif of paxillin is influenced by externally applied force...
  11. ncbi request reprint Airway wall mechanics
    R D Kamm
    Department of Mechanical Engineering and Division of Bioengineering and Environmental Health, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Annu Rev Biomed Eng 1:47-72. 1999
    ..Simulations of airway constriction in normal and asthmatic airways are discussed. To the extent possible, comparisons are presented between the various models and existing experimental data...
  12. ncbi request reprint Cellular fluid mechanics
    Roger D Kamm
    Department of Mechanical Engineering and Division of Bioengineering and Environmental Health, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Annu Rev Fluid Mech 34:211-32. 2002
    ..We also discuss flows in the vicinity of noncirculating cells, the influence of fluid dynamic shear stress on cell biology, and diffusion in the lipid bi-layer, all in the context of the important fluid-dynamic phenomena...
  13. pmc Tension, free space, and cell damage in a microfluidic wound healing assay
    Michael Murrell
    Department of Biological Engineering Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
    PLoS ONE 6:e24283. 2011
    ..Surprisingly, when coupled with a gradient in ROS to simulate the chemical effects of abrasion however, motility was not restored, but further inhibited...
  14. pmc A three-dimensional viscoelastic model for cell deformation with experimental verification
    Helene Karcher
    Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Biophys J 85:3336-49. 2003
    ..Modulation of cell height has little effect on the results, provided the monolayer is >5 micro m thick. NIH 3T3 fibroblasts exhibited a viscoelastic timescale of approximately 1 s and a shear modulus of approximately 1000 Pa...
  15. pmc Interstitial fluid flow intensity modulates endothelial sprouting in restricted Src-activated cell clusters during capillary morphogenesis
    Rodrigo Hernández Vera
    Center for Biomedical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Tissue Eng Part A 15:175-85. 2009
    ..Src (pSrc)) at the monolayer, suggesting that the transduction pathway in charge of sensing the mechanical stimulus induced by flow is promoting predetermined mechanically sensitive areas (pSrc) to undergo capillary morphogenesis..
  16. pmc Design, fabrication and implementation of a novel multi-parameter control microfluidic platform for three-dimensional cell culture and real-time imaging
    Vernella Vickerman
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA
    Lab Chip 8:1468-77. 2008
    ....
  17. pmc A microfluidic device to investigate axon targeting by limited numbers of purified cortical projection neuron subtypes
    Suzanne Tharin
    Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA
    Integr Biol (Camb) 4:1398-405. 2012
    ..This device will be uniquely enabling for investigation of controls over axon growth and neuronal survival of many types of neurons, particularly those available only in limited numbers...
  18. pmc Substrate viscosity enhances correlation in epithelial sheet movement
    Michael Murrell
    Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Biophys J 101:297-306. 2011
    ..For G'(ω) > G'(ω), this balance shifts, and contraction of the tissue drives the substrate to flow, further elevating the correlation in movement...
  19. doi request reprint A stochastic broadcast feedback approach to regulating cell population morphology for microfluidic angiogenesis platforms
    Levi Benjamin Wood
    Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139
    IEEE Trans Biomed Eng 56:2299-303. 2009
    ..Initial simulation experiments demonstrate that vascular development can be guided toward a desired morphologic pattern using this technique...
  20. doi request reprint A hybrid continuum-discrete modelling approach to predict and control angiogenesis: analysis of combinatorial growth factor and matrix effects on vessel-sprouting morphology
    Anusuya Das
    Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA
    Philos Trans A Math Phys Eng Sci 368:2937-60. 2010
    ..Thus, this model can be used to cluster sprout morphology as a function of various influencing factors...
  21. pmc Fast fluorescence laser tracking microrheometry, II: quantitative studies of cytoskeletal mechanotransduction
    Maxine Jonas
    Departments of Biological Engineering and Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Biophys J 95:895-909. 2008
    ....
  22. pmc Fast fluorescence laser tracking microrheometry. I: instrument development
    Maxine Jonas
    Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Biophys J 94:1459-69. 2008
    ..An upcoming companion article will illustrate the use of FLTM in studying the solid-like versus liquid-like rheological properties of fibroblast cytoskeletons in living biological samples...
  23. pmc Computational model for cell migration in three-dimensional matrices
    Muhammad H Zaman
    Whitehead Institute for Biomedical Research, Biological Engineering Division, Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, 02142, USA
    Biophys J 89:1389-97. 2005
    ..As one particular sample manifestation of these effects, the optimal levels of cell receptor expression and matrix ligand density yielding maximal migration are dependent on matrix mechanical compliance...
  24. ncbi request reprint Autocrine EGF receptor activation mediates endothelial cell migration and vascular morphogenesis induced by VEGF under interstitial flow
    Carlos E Semino
    Center for Biomedical Engineering and Biological Engineering Division, Massachusetts Institute of Technology, 77 Massachusetts Avenue, NE47 383, MIT, Cambridge, MA 02139, USA
    Exp Cell Res 312:289-98. 2006
    ....
  25. doi request reprint Cell migration into scaffolds under co-culture conditions in a microfluidic platform
    Seok Chung
    Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA
    Lab Chip 9:269-75. 2009
    ....
  26. pmc A coarse-grained model for force-induced protein deformation and kinetics
    Helene Karcher
    Department of Mechanical Engineering and Division of Biological Engineering, Massachusetts Institute of Technology, Cambridge, 02139, USA
    Biophys J 90:2686-97. 2006
    ..Two model systems are used to demonstrate the utility of this approach: a short alpha-helix undergoing a transition between two well-defined states and a simple molecular motor...
  27. ncbi request reprint A biomechanical model of sagittal tongue bending
    Vitaly J Napadow
    Department of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge 02139, USA
    J Biomech Eng 124:547-56. 2002
    ..This fundamental reliance of tongue bending on the synergistic contraction of its intrinsic fibers supports the muscular hydrostat theory of tongue function...
  28. ncbi request reprint Endothelial nitric oxide production during in vitro simulation of external limb compression
    Guohao Dai
    Division of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Am J Physiol Heart Circ Physiol 282:H2066-75. 2002
    ..These results implicate enhanced NO release as a potentially important factor in the prevention of DVT...
  29. ncbi request reprint Mucosal folding in biologic vessels
    Constantine A Hrousis
    Center for Biomedical Engineering, Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, USA
    J Biomech Eng 124:334-41. 2002
    ....
  30. pmc Synergistic effects of tethered growth factors and adhesion ligands on DNA synthesis and function of primary hepatocytes cultured on soft synthetic hydrogels
    Geeta Mehta
    Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Biomaterials 31:4657-71. 2010
    ..These modular matrices reveal new facets of hepatocellular biology in culture and may be more broadly useful in culture of other soft tissues...
  31. pmc Passive and active microrheology for cross-linked F-actin networks in vitro
    Hyungsuk Lee
    Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Acta Biomater 6:1207-18. 2010
    ..Finally, we propose a model of network connectivity by investigating the effect of filament length on the mechanical properties and structure...
  32. pmc Transport-mediated angiogenesis in 3D epithelial coculture
    Ryo Sudo
    Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA 02139, USA
    FASEB J 23:2155-64. 2009
    ..The experimental approach described here is useful more generally for investigating microvascular networks within 3D engineered tissues with multiple cell types in vitro...
  33. doi request reprint Nanointerstice-driven microflow
    Seok Chung
    Department of Mechanical Engineering, Massachusetts Institute of Technology Cambridge, MA 02139, USA
    Small 5:609-13. 2009
    ..The results show that NI flow generation can be a useful alternative technique to create long-term predictable flow in commercialized products with microchannels...
  34. ncbi request reprint Self-assembling short oligopeptides and the promotion of angiogenesis
    Daria A Narmoneva
    Cardiovascular Division, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02139, USA
    Biomaterials 26:4837-46. 2005
    ..Since these peptides can be modified in many ways, they may be uniquely valuable in regeneration of vascularized tissues...
  35. pmc Elastic deformation and failure in protein filament bundles: Atomistic simulations and coarse-grained modeling
    Nathan A Hammond
    Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Biomaterials 29:3152-60. 2008
    ..With insight from these simulations, we discuss strategies for strengthening RAD16-II and similar materials...
  36. ncbi request reprint A microfabricated array bioreactor for perfused 3D liver culture
    Mark J Powers
    Division of Bioengineering and Environmental Health, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Biotechnol Bioeng 78:257-69. 2002
    ..We also demonstrate repeated in situ imaging of tissue structure and function using two-photon microscopy...
  37. ncbi request reprint Mechanical deformation of neutrophils into narrow channels induces pseudopod projection and changes in biomechanical properties
    Belinda Yap
    Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    J Appl Physiol 98:1930-9. 2005
    ....
  38. pmc Lamin A/C deficiency causes defective nuclear mechanics and mechanotransduction
    Jan Lammerding
    Biological Engineering Division, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    J Clin Invest 113:370-8. 2004
    ..These findings suggest that the tissue-specific effects of lamin A/C mutations observed in the laminopathies may arise from varying degrees of impaired nuclear mechanics and transcriptional activation...
  39. pmc VASP involvement in force-mediated adherens junction strengthening
    Anita S Kris
    Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Biochem Biophys Res Commun 375:134-8. 2008
    ..These results indicate that force-mediated adhesion strengthening occurs in endothelial adherens junctions and that dynamic VASP activity is necessary for this process...
  40. ncbi request reprint Cell mechanics and mechanotransduction: pathways, probes, and physiology
    Hayden Huang
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02139, USA
    Am J Physiol Cell Physiol 287:C1-11. 2004
    ....
  41. doi request reprint A high-throughput microfluidic assay to study neurite response to growth factor gradients
    Chandrasekhar R Kothapalli
    Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Lab Chip 11:497-507. 2011
    ....
  42. doi request reprint A microfluidic system with optical laser tweezers to study mechanotransduction and focal adhesion recruitment
    Peyman Honarmandi
    Massachusetts Institute of Technology MIT, Department of Biological Engineering, Cambridge, MA 02139, USA
    Lab Chip 11:684-94. 2011
    ..9 ± 6.4 pN μm(-1) for a 5 μm × 5 μm membrane segment. This method provides a foundation for further studies of mechanotransduction and tensile stiffness of single cells...
  43. ncbi request reprint Effects of systematic variation of amino acid sequence on the mechanical properties of a self-assembling, oligopeptide biomaterial
    Michael R Caplan
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge 02139, USA
    J Biomater Sci Polym Ed 13:225-36. 2002
    ..Thus, diverse aspects of these molecules can be designed rationally to yield desirable materials properties of different types...
  44. pmc Neutrophil transit times through pulmonary capillaries: the effects of capillary geometry and fMLP-stimulation
    Mark Bathe
    Department of Mechanical Engineering and Division of Biological Engineering, Massachusetts Institute of Technology, Cambridge 02139, USA
    Biophys J 83:1917-33. 2002
    ..The relative effects of capillary geometry and fMLP on neutrophil transit time are presented as a simple dimensionless expression and their physiological significance is discussed...
  45. pmc Measuring molecular rupture forces between single actin filaments and actin-binding proteins
    Jorge M Ferrer
    Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 105:9221-6. 2008
    ..With this modular, single-molecule assay, a wide range of ABP/actin interactions can be studied to better understand cytoskeletal and cell dynamics...
  46. ncbi request reprint Model-based assessment of cardiovascular health from noninvasive measurements
    Xinshu Xiao
    Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge 02139, USA
    Ann Biomed Eng 30:612-23. 2002
    ..Simulations were also performed to test the ability of the approach to predict changes in SVR and E(LV) from an initial base line state...
  47. ncbi request reprint Force-induced activation of talin and its possible role in focal adhesion mechanotransduction
    Seung E Lee
    Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    J Biomech 40:2096-106. 2007
    ..Activation was observed with mean force of 13.2 +/-8.0 pN during constant velocity simulation and with steady force greater than 18.0 pN...
  48. ncbi request reprint Mechanotransduction in cardiac myocytes
    Jan Lammerding
    Biological Engineering Division, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Ann N Y Acad Sci 1015:53-70. 2004
    ..New and refined experimental techniques will exploit advances in molecular biology and biological imaging to study mechanotransduction in isolated cells and genetically engineered mice to explore the function of individual proteins...
  49. pmc Three-dimensional cellular deformation analysis with a two-photon magnetic manipulator workstation
    Hayden Huang
    Department of Mechanical Engineering, MIT, Cambridge, Massachusetts 02139, USA
    Biophys J 82:2211-23. 2002
    ..These measurements indicate that the response of cells to large focal stresses may contain three-dimensional global deformations and show the suitability of this workstation to further studying cellular response to mechanical stresses...
  50. pmc Kinetic control of dimer structure formation in amyloid fibrillogenesis
    Wonmuk Hwang
    Center for Biomedical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 101:12916-21. 2004
    ..These results suggest that kinetic trapping could play a role in the structural evolution of early aggregates in amyloid fibrillogenesis...
  51. ncbi request reprint Nuclear mechanics and methods
    Jan Lammerding
    Department of Medicine, Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Methods Cell Biol 83:269-94. 2007
    ..Various methods to measure nuclear mechanics, isolated or in situ, are outlined here in some detail...
  52. ncbi request reprint Cellular fluid mechanics and mechanotransduction
    John M Tarbell
    Department of Biomedical Engineering, City College of New York, New York, NY, USA
    Ann Biomed Eng 33:1719-23. 2005
    ..All of these possibilities are reviewed from an integrated perspective...
  53. ncbi request reprint Mechanotransduction through growth-factor shedding into the extracellular space
    Daniel J Tschumperlin
    Physiology Program, Department of Environmental Health, Harvard School of Public Health, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 429:83-6. 2004
    ....
  54. pmc Atomistic simulation approach to a continuum description of self-assembled beta-sheet filaments
    Jiyong Park
    School of Physics and Center for Theoretical Physics, Seoul National University, Seoul, Korea
    Biophys J 90:2510-24. 2006
    ..The generality of our approach suggests that it should be applicable to developing continuum elastic ribbon models of other beta-sheet filaments and amyloid fibrils...
  55. pmc Injectable self-assembling peptide nanofibers create intramyocardial microenvironments for endothelial cells
    Michael E Davis
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, USA
    Circulation 111:442-50. 2005
    ..We hypothesized that a novel approach to promote vascularization would be to create injectable microenvironments within the myocardium that recruit endothelial cells and promote their survival and organization...
  56. pmc Distinct endothelial phenotypes evoked by arterial waveforms derived from atherosclerosis-susceptible and -resistant regions of human vasculature
    Guohao Dai
    Center for Excellence in Vascular Biology, Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 101:14871-6. 2004
    ..These global gene expression patterns and functional data reveal a distinct phenotypic modulation in response to the wall shear stresses present in atherosclerosis-susceptible vs. atherosclerosis-resistant human arterial geometries...
  57. ncbi request reprint Stress transmission in the lung: pathways from organ to molecule
    Jeffrey J Fredberg
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Annu Rev Physiol 68:507-41. 2006
    ..Importantly, evidence has now accumulated suggesting that multiscale phenomena span these scales and govern integrative lung behavior...
  58. pmc Endothelial cells promote cardiac myocyte survival and spatial reorganization: implications for cardiac regeneration
    Daria A Narmoneva
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, USA
    Circulation 110:962-8. 2004
    ..This study tested the hypothesis that endothelial cells (ECs) promote CM survival and enhance spatial organization in a 3-dimensional configuration...
  59. ncbi request reprint Computational modeling of cardiovascular response to orthostatic stress
    Thomas Heldt
    Harvard University Massachusetts Institute of Technology Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Appl Physiol 92:1239-54. 2002
    ..A case study is presented on how the model is intended to be used in the future to investigate the effects of post-spaceflight orthostatic intolerance...

Research Grants9

  1. NUMERICAL ANALYSIS OF FLOW AND TISSUE DEFORMATION
    Roger Kamm; Fiscal Year: 2001
    ..Specific Aim 3. To test the hypothesis that sites of inflammation/degradation correlate with regions within the tissue that experience high mechanical strain. ..
  2. NUMERICAL ANALYSIS OF FLOW AND TISSUE DEFORMATION
    Roger Kamm; Fiscal Year: 1999
    ..Specific Aim 3. To test the hypothesis that sites of inflammation/degradation correlate with regions within the tissue that experience high mechanical strain. ..
  3. NUMERICAL ANALYSIS OF FLOW AND TISSUE DEFORMATION
    Roger Kamm; Fiscal Year: 2000
    ..Specific Aim 3. To test the hypothesis that sites of inflammation/degradation correlate with regions within the tissue that experience high mechanical strain. ..
  4. MSM-Multi-scale Analysis of Cellular Force Transmission and Biochemical Activatio
    Roger Kamm; Fiscal Year: 2005
    ..4. Conduct experiments in reconstituted actin networks to provide a pheonological basis for evaluation and evalidation of the computational models. ..
  5. MSM-Multi-scale Analysis of Cellular Force Transmission and Biochemical Activatio
    Roger Kamm; Fiscal Year: 2006
    ..4. Conduct experiments in reconstituted actin networks to provide a pheonological basis for evaluation and evalidation of the computational models. ..
  6. Molecular, Cell and Tissue Biomechanics Training Grant
    Roger Kamm; Fiscal Year: 2007
    ..Imaging and quantitative analysis are considered essential tools in understanding biomechanical structures. ..
  7. MSM-Multi-scale Analysis of Cellular Force Transmission and Biochemical Activatio
    Roger Kamm; Fiscal Year: 2007
    ..4. Conduct experiments in reconstituted actin networks to provide a pheonological basis for evaluation and evalidation of the computational models. ..