URSULA KAISER

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi request reprint Activin A augments GnRH-mediated transcriptional activation of the mouse GnRH receptor gene
    Errol R Norwitz
    Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Endocrinology 143:985-97. 2002
  2. ncbi request reprint A novel mouse model of hypogonadotrophic hypogonadism: N-ethyl-N-nitrosourea-induced gonadotropin-releasing hormone receptor gene mutation
    Andrew J Pask
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Mol Endocrinol 19:972-81. 2005
  3. ncbi request reprint TACR3 mutations disrupt NK3R function through distinct mechanisms in GnRH-deficient patients
    Sekoni D Noel
    1Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital, 221 Longwood Ave, Boston, MA 02115, USA
    FASEB J 28:1924-37. 2014
  4. pmc GnRH pulse frequency-dependent stimulation of FSHβ transcription is mediated via activation of PKA and CREB
    Iain R Thompson
    Division of Endocrinology, Diabetes and Hypertension, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Mol Endocrinol 27:606-18. 2013
  5. pmc Evidence of the importance of the first intracellular loop of prokineticin receptor 2 in receptor function
    Ana Paula Abreu
    Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Endocrinol 26:1417-27. 2012
  6. pmc Genetic labeling: new approaches to creating a gonadotroph "ID"
    Ursula B Kaiser
    Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Endocrinology 149:2699-700. 2008
  7. ncbi request reprint New gatekeepers of reproduction: GPR54 and its cognate ligand, KiSS-1
    Stephanie B Seminara
    Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital, 221 Longwood Avenue, Boston, Massachusetts 02115, USA
    Endocrinology 146:1686-8. 2005
  8. ncbi request reprint KiSS-1 and GPR54 as new players in gonadotropin regulation and puberty
    Ursula B Kaiser
    Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Endocrine 26:277-84. 2005
  9. ncbi request reprint Four naturally occurring mutations in the human GnRH receptor affect ligand binding and receptor function
    Gregoy Y Bedecarrats
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA
    Mol Cell Endocrinol 205:51-64. 2003
  10. pmc Essential role of the homeodomain for pituitary homeobox 1 activation of mouse gonadotropin-releasing hormone receptor gene expression through interactions with c-Jun and DNA
    Kyeong Hoon Jeong
    Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell Biol 24:6127-39. 2004

Research Grants

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Activin A augments GnRH-mediated transcriptional activation of the mouse GnRH receptor gene
    Errol R Norwitz
    Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Endocrinology 143:985-97. 2002
    ..These data demonstrate that activin augments GnRH-mediated transcriptional activation of the mGnRHR gene and suggest that this effect may be mediated through SMAD transcription factors...
  2. ncbi request reprint A novel mouse model of hypogonadotrophic hypogonadism: N-ethyl-N-nitrosourea-induced gonadotropin-releasing hormone receptor gene mutation
    Andrew J Pask
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Mol Endocrinol 19:972-81. 2005
    ..This is the first report of a mouse with a Gnrhr loss of function mutation. These GnRH-insensitive mice provide a novel animal model for the study of human idiopathic hypogonadotrophic hypogonadism...
  3. ncbi request reprint TACR3 mutations disrupt NK3R function through distinct mechanisms in GnRH-deficient patients
    Sekoni D Noel
    1Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital, 221 Longwood Ave, Boston, MA 02115, USA
    FASEB J 28:1924-37. 2014
    ..Collectively, our data illustrate roles for TM5 and TM6 in NK3R trafficking and ligand binding and for IL3 in NK3R signaling...
  4. pmc GnRH pulse frequency-dependent stimulation of FSHβ transcription is mediated via activation of PKA and CREB
    Iain R Thompson
    Division of Endocrinology, Diabetes and Hypertension, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Mol Endocrinol 27:606-18. 2013
    ....
  5. pmc Evidence of the importance of the first intracellular loop of prokineticin receptor 2 in receptor function
    Ana Paula Abreu
    Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Endocrinol 26:1417-27. 2012
    ..In summary, we have shown the importance of Arg80 in ICL1 for PROKR2 expression and demonstrate that R80C PROKR2 exerts a dominant negative effect on WT PROKR2...
  6. pmc Genetic labeling: new approaches to creating a gonadotroph "ID"
    Ursula B Kaiser
    Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Endocrinology 149:2699-700. 2008
  7. ncbi request reprint New gatekeepers of reproduction: GPR54 and its cognate ligand, KiSS-1
    Stephanie B Seminara
    Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital, 221 Longwood Avenue, Boston, Massachusetts 02115, USA
    Endocrinology 146:1686-8. 2005
  8. ncbi request reprint KiSS-1 and GPR54 as new players in gonadotropin regulation and puberty
    Ursula B Kaiser
    Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Endocrine 26:277-84. 2005
    ..Taken together, these findings weave a compelling case for a role of the kisspeptin-GPR54 system in the activation of GnRH neurons at the time of pubertal awakening of the reproductive axis...
  9. ncbi request reprint Four naturally occurring mutations in the human GnRH receptor affect ligand binding and receptor function
    Gregoy Y Bedecarrats
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA
    Mol Cell Endocrinol 205:51-64. 2003
    ..All four amino acid substitutions interfered with ligand binding, and affected signal transduction and stimulation of gonadotropin and GnRHR gene expression in response to GnRH...
  10. pmc Essential role of the homeodomain for pituitary homeobox 1 activation of mouse gonadotropin-releasing hormone receptor gene expression through interactions with c-Jun and DNA
    Kyeong Hoon Jeong
    Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell Biol 24:6127-39. 2004
    ....
  11. ncbi request reprint The GPR54 gene as a regulator of puberty
    Stephanie B Seminara
    Reproductive Endocrine Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    N Engl J Med 349:1614-27. 2003
    ..We conducted studies in humans and mice to identify the genetic factors that determine the onset of puberty...
  12. ncbi request reprint Regulation of gonadotropins by inhibin and activin
    Susan J Gregory
    Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Semin Reprod Med 22:253-67. 2004
    ..Finally, we present recent findings that other members of the transforming growth factor beta superfamily may also play an important role in transcriptional regulation of the pituitary gonadotropins...
  13. ncbi request reprint Synergy between activin A and gonadotropin-releasing hormone in transcriptional activation of the rat follicle-stimulating hormone-beta gene
    Susan J Gregory
    Brigham and Women s Hospital and Harvard Medical School, Division of Endocrinology, Diabetes and Hypertension, 221 Longwood Avenue, Boston, Massachusetts 02115, USA
    Mol Endocrinol 19:237-54. 2005
    ..The results indicate that SMAD3 plays an important role in the synergistic effects of activin and GnRH and demonstrate that this synergy is mediated by a palindromic cis-element located at -266/-259 of the rFSHbeta gene promoter...
  14. pmc Expression of a gonadotropin-releasing hormone receptor-simian virus 40 T-antigen transgene has sex-specific effects on the reproductive axis
    Kyeong Hoon Jeong
    Harvard Medical School, Brigham and Women s Hospital, Division of Endocrinology, Diabetes and Hypertension, 221 Longwood Avenue, Boston, Massachusetts 02115, USA
    Endocrinology 150:3383-91. 2009
    ..We conclude that the expression of the TAg transgene driven by the GnRHR gene promoter results in female-specific infertility due to disruption of gonadotropin production and secretion even before tumor development...
  15. ncbi request reprint Pituitary homeobox 1 activates the rat FSHbeta (rFSHbeta) gene through both direct and indirect interactions with the rFSHbeta gene promoter
    Marjorie M Zakaria
    Endocrine Hypertension Division, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Endocrinol 16:1840-52. 2002
    ..These results identify a functional Ptx1 binding site in the rFSHbeta gene promoter and suggest the presence of an additional activating pathway that is independent of direct binding of Ptx1 to the promoter...
  16. ncbi request reprint GPR54 and KiSS-1: role in the regulation of puberty and reproduction
    Wendy Kuohung
    Department of Obstetrics and Gynecology, Boston University School of Medicine, Boston, MA 02118, USA
    Rev Endocr Metab Disord 7:257-63. 2006
    ..In the future, modulators of GPR54 activity, including kisspeptin, may prove valuable in clinical applications in the fields of both cancer therapy and reproductive medicine...
  17. pmc A composite element that binds basic helix loop helix and basic leucine zipper transcription factors is important for gonadotropin-releasing hormone regulation of the follicle-stimulating hormone beta gene
    Nick A Ciccone
    Brigham and Women s Hospital, Division of Endocrinology, Diabetes and Hypertension, 221 Longwood Avenue, Boston, Massachusetts 0211, USA
    Mol Endocrinol 22:1908-23. 2008
    ..In conclusion, a composite element bound by both USF and CREB serves to integrate signals for basal and GnRH-stimulated transcription of the rat FSHbeta gene...
  18. pmc Human GnRH deficiency: a unique disease model to unravel the ontogeny of GnRH neurons
    Ravikumar Balasubramanian
    Harvard Reproductive Endocrine Sciences Center of Excellence, Reproductive Endocrine Unit of the Department of Medicine of the Massachusetts General Hospital and Endocrine Division of the Brigham and Women s Hospital, Boston, MA 02114, USA
    Neuroendocrinology 92:81-99. 2010
    ..These insights now provide practicing clinicians with targeted genetic diagnostic strategies and also impact on clinical management...
  19. pmc Reproductive hormone-dependent and -independent contributions to developmental changes in kisspeptin in GnRH-deficient hypogonadal mice
    John C Gill
    Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 5:e11911. 2010
    ....
  20. ncbi request reprint Oct-1 and nuclear factor Y bind to the SURG-1 element to direct basal and gonadotropin-releasing hormone (GnRH)-stimulated mouse GnRH receptor gene transcription
    Kyung Yoon Kam
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 221 Longwood Avenue, Boston, Massachusetts 02115, USA
    Mol Endocrinol 19:148-62. 2005
    ..In conclusion, NF-Y and Oct-1 bind to the SURG-1 element to direct basal and GnRH-stimulated expression of the mGnRHR gene...
  21. ncbi request reprint Direct binding of AP-1 (Fos/Jun) proteins to a SMAD binding element facilitates both gonadotropin-releasing hormone (GnRH)- and activin-mediated transcriptional activation of the mouse GnRH receptor gene
    Errol R Norwitz
    Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 277:37469-78. 2002
    ....
  22. pmc Regulation of gonadotropin gene expression by Mullerian inhibiting substance
    Gregoy Y Bedecarrats
    Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 100:9348-53. 2003
    ....
  23. ncbi request reprint GNRHR mutations in a woman with idiopathic hypogonadotropic hypogonadism highlight the differential sensitivity of luteinizing hormone and follicle-stimulating hormone to gonadotropin-releasing hormone
    Astrid U Meysing
    Reproductive Endocrine Unit, Bartlett Hall Extension 5, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Endocrinol Metab 89:3189-98. 2004
    ....
  24. ncbi request reprint Two common naturally occurring mutations in the human gonadotropin-releasing hormone (GnRH) receptor have differential effects on gonadotropin gene expression and on GnRH-mediated signal transduction
    Gregoy Y Bedecarrats
    Endocrine Hypertension Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Endocrinol Metab 88:834-43. 2003
    ..The differential stimulation of LH beta, FSH beta, and alpha GSU gene expression may contribute to the varied phenotypes observed among patients harboring these mutations...
  25. ncbi request reprint Differential regulation of gonadotropin subunit gene promoter activity by pulsatile gonadotropin-releasing hormone (GnRH) in perifused L beta T2 cells: role of GnRH receptor concentration
    Gregoy Y Bedecarrats
    Endocrine Hypertension Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Endocrinology 144:1802-11. 2003
    ..Furthermore, our studies indicate that cell-surface GnRHR density is a critical mediator of this differential regulation...
  26. pmc The biology of gonadotroph regulation
    Nick A Ciccone
    Division of Endocrinology, Diabetes and Hypertension, Brigham and Women s Hospital and Harvard Medical School, 221 Longwood Avenue, Boston, Massachusetts 02115, USA
    Curr Opin Endocrinol Diabetes Obes 16:321-7. 2009
    ....
  27. pmc Impaired fibroblast growth factor receptor 1 signaling as a cause of normosmic idiopathic hypogonadotropic hypogonadism
    Taneli Raivio
    Reproductive Endocrine Unit, Department of Medicine, The Harvard Center for Reproductive Endocrine Sciences, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 94:4380-90. 2009
    ..FGFR1 mutations have been identified in about 10% of patients with Kallmann syndrome. Recently cases of idiopathic hypogonadotropic hypogonadism (IHH) with a normal sense of smell (nIHH) have been reported...
  28. pmc TAC3/TACR3 mutations reveal preferential activation of gonadotropin-releasing hormone release by neurokinin B in neonatal life followed by reversal in adulthood
    Elena Gianetti
    Harvard Center for Reproductive Sciences and Reproductive Endocrine Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 95:2857-67. 2010
    ....
  29. pmc The gonadotropin-releasing hormone (GnRH) neuronal population is normal in size and distribution in GnRH-deficient and GnRH receptor-mutant hypogonadal mice
    John C Gill
    Division of Endocrinology, Diabetes and Hypertension, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Endocrinology 149:4596-604. 2008
    ..These data establish that autocrine-paracrine GnRH-signaling is not a prerequisite for the developmental migration of GnRH neurons into the brain or for the projection of GnRH neurosecretory axons...
  30. ncbi request reprint Gonadotropin-releasing hormone pulse frequency-dependent activation of extracellular signal-regulated kinase pathways in perifused LbetaT2 cells
    Haruhiko Kanasaki
    Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Endocrinology 146:5503-13. 2005
    ....
  31. pmc Frequency-dependent regulation of follicle-stimulating hormone beta by pulsatile gonadotropin-releasing hormone is mediated by functional antagonism of bZIP transcription factors
    Nick A Ciccone
    Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital, 221 Longwood Ave, Boston, MA 02115, USA
    Mol Cell Biol 30:1028-40. 2010
    ..These data suggest that ICER production antagonizes the stimulatory action of CREB to attenuate FSH beta transcription at high GnRH pulse frequencies, thereby playing a critical role in regulating cyclic reproductive function...
  32. doi request reprint Lymphocytic hypophysitis with diabetes insipidus in a young man
    Ole Petter R Hamnvik
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Nat Rev Endocrinol 6:464-70. 2010
    ..Subsequent scanning revealed a suprasellar mass, which demonstrated progressive enlargement on serial imaging. He also developed hypogonadotropic hypogonadism...
  33. pmc Human LSD2/KDM1b/AOF1 regulates gene transcription by modulating intragenic H3K4me2 methylation
    Rui Fang
    Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, Brigham and Women s Hospital, 221 Longwood Avenue, Boston, MA 02115, USA
    Mol Cell 39:222-33. 2010
    ..These data provide a possible molecular mechanism linking LSD2 to transcriptional regulation after initiation...
  34. pmc A GPR54-activating mutation in a patient with central precocious puberty
    Milena Gurgel Teles
    Developmental Endocrinology Unit, Medical Investigation Laboratory, Clinicas Hospital, Sao Paulo University Medical School, Sao Paulo
    N Engl J Med 358:709-15. 2008
    ..In vitro studies have shown that this mutation leads to prolonged activation of intracellular signaling pathways in response to kisspeptin. The Arg386Pro mutant appears to be associated with central precocious puberty...
  35. ncbi request reprint Pubertal impairment in Nhlh2 null mice is associated with hypothalamic and pituitary deficiencies
    Tiziana Cogliati
    Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20889, USA
    Mol Endocrinol 21:3013-27. 2007
    ....
  36. ncbi request reprint Mutations in the human gonadotropin-releasing hormone receptor: insights into receptor biology and function
    Gregoy Y Bedecarrats
    Department of Animal and Poultry Science, Ontario Agricultural College, University of Guelph, Guelph, Ontario, Canada
    Semin Reprod Med 25:368-78. 2007
    ..Furthermore, given that it was recently demonstrated that pharmacological chaperones can rescue altered receptor function in vitro, potential therapeutic approaches are also discussed...

Research Grants17

  1. REPRODUCTIVE PHYSIOLOGY OF GONADOTROPIN SYNTHESIS
    URSULA KAISER; Fiscal Year: 2000
    ....
  2. REPRODUCTIVE PHYSIOLOGY OF GONADOTROPIN SYNTHESIS
    URSULA KAISER; Fiscal Year: 2009
    ..abstract_text> ..
  3. Use of Gene Therapy: A Tool to Study Reproductive Function
    URSULA KAISER; Fiscal Year: 2009
    ..abstract_text> ..
  4. REPRODUCTIVE PHYSIOLOGY OF GONADOTROPIN SYNTHESIS
    URSULA KAISER; Fiscal Year: 2009
    ..abstract_text> ..
  5. REPRODUCTIVE PHYSIOLOGY OF GONADOTROPIN SYNTHESIS
    URSULA KAISER; Fiscal Year: 2007
    ..abstract_text> ..
  6. GENE THERAPY FOR RESCUE OF REPRODUCTIVE FUNCTION
    URSULA KAISER; Fiscal Year: 2006
    ....
  7. REPRODUCTIVE PHYSIOLOGY OF GONADOTROPIN SYNTHESIS
    URSULA KAISER; Fiscal Year: 2006
    ..abstract_text> ..
  8. REPRODUCTIVE BIOLOGY OF GONADOTROPIN REGULATION
    URSULA KAISER; Fiscal Year: 2005
    ..abstract_text> ..
  9. REPRODUCTIVE PHYSIOLOGY OF GONADOTROPIN SYNTHESIS
    URSULA KAISER; Fiscal Year: 2005
    ..abstract_text> ..
  10. REPRODUCTIVE BIOLOGY OF GONADOTROPIN REGULATION
    URSULA KAISER; Fiscal Year: 2004
    ..abstract_text> ..
  11. REPRODUCTIVE BIOLOGY OF GONADOTROPIN REGULATION
    URSULA KAISER; Fiscal Year: 2003
    ..abstract_text> ..
  12. REPRODUCTIVE BIOLOGY OF GONADOTROPIN REGULATION
    URSULA KAISER; Fiscal Year: 2002
    ..abstract_text> ..
  13. REPRODUCTIVE PHYSIOLOGY OF GONADOTROPIN SYNTHESIS
    URSULA KAISER; Fiscal Year: 2002
    ....
  14. REPRODUCTIVE BIOLOGY OF GONADOTROPIN REGULATION
    URSULA KAISER; Fiscal Year: 2001
    ..abstract_text> ..
  15. REPRODUCTIVE PHYSIOLOGY OF GONADOTROPIN SYNTHESIS
    URSULA KAISER; Fiscal Year: 2001
    ....
  16. Use of Gene Therapy: A Tool to Study Reproductive Function
    Ursula B Kaiser; Fiscal Year: 2010
    ..abstract_text> ..