Research Topics
Genomes and Genes | URSULA KAISERSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
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Publications
Activin A augments GnRH-mediated transcriptional activation of the mouse GnRH receptor geneErrol R Norwitz
Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Endocrinology 143:985-97. 2002..These data demonstrate that activin augments GnRH-mediated transcriptional activation of the mGnRHR gene and suggest that this effect may be mediated through SMAD transcription factors...- A novel mouse model of hypogonadotrophic hypogonadism: N-ethyl-N-nitrosourea-induced gonadotropin-releasing hormone receptor gene mutationAndrew J Pask
Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Mol Endocrinol 19:972-81. 2005..This is the first report of a mouse with a Gnrhr loss of function mutation. These GnRH-insensitive mice provide a novel animal model for the study of human idiopathic hypogonadotrophic hypogonadism... 
GnRH Pulse Frequency-Dependent Stimulation of FSHβ Transcription Is Mediated via Activation of PKA and CREBIain R Thompson
Brigham and Women s Hospital, Division of Endocrinology, Diabetes and Hypertension, 221 Longwood Avenue, Boston, MA 02115
Mol Endocrinol 27:606-18. 2013....- Evidence of the importance of the first intracellular loop of prokineticin receptor 2 in receptor functionAna Paula Abreu
Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Mol Endocrinol 26:1417-27. 2012..In summary, we have shown the importance of Arg80 in ICL1 for PROKR2 expression and demonstrate that R80C PROKR2 exerts a dominant negative effect on WT PROKR2... - New gatekeepers of reproduction: GPR54 and its cognate ligand, KiSS-1Stephanie B Seminara
Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women's Hospital, 221 Longwood Avenue, Boston, Massachusetts 02115, USA
Endocrinology 146:1686-8. 2005 - KiSS-1 and GPR54 as new players in gonadotropin regulation and pubertyUrsula B Kaiser
Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Endocrine 26:277-84. 2005..Taken together, these findings weave a compelling case for a role of the kisspeptin-GPR54 system in the activation of GnRH neurons at the time of pubertal awakening of the reproductive axis... - Genetic labeling: new approaches to creating a gonadotroph "ID"Ursula B Kaiser
Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA
Endocrinology 149:2699-700. 2008 - Four naturally occurring mutations in the human GnRH receptor affect ligand binding and receptor functionGregoy Y Bedecarrats
Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA
Mol Cell Endocrinol 205:51-64. 2003..All four amino acid substitutions interfered with ligand binding, and affected signal transduction and stimulation of gonadotropin and GnRHR gene expression in response to GnRH... - Essential role of the homeodomain for pituitary homeobox 1 activation of mouse gonadotropin-releasing hormone receptor gene expression through interactions with c-Jun and DNAKyeong Hoon Jeong
Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Mol Cell Biol 24:6127-39. 2004.... - The GPR54 gene as a regulator of pubertyStephanie B Seminara
Reproductive Endocrine Unit, Massachusetts General Hospital, Boston, MA 02114, USA
N Engl J Med 349:1614-27. 2003..We conducted studies in humans and mice to identify the genetic factors that determine the onset of puberty... - Regulation of gonadotropins by inhibin and activinSusan J Gregory
Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Semin Reprod Med 22:253-67. 2004..Finally, we present recent findings that other members of the transforming growth factor beta superfamily may also play an important role in transcriptional regulation of the pituitary gonadotropins... - GPR54 and KiSS-1: role in the regulation of puberty and reproductionWendy Kuohung
Department of Obstetrics and Gynecology, Boston University School of Medicine, Boston, MA 02118, USA
Rev Endocr Metab Disord 7:257-63. 2006..In the future, modulators of GPR54 activity, including kisspeptin, may prove valuable in clinical applications in the fields of both cancer therapy and reproductive medicine... - Expression of a gonadotropin-releasing hormone receptor-simian virus 40 T-antigen transgene has sex-specific effects on the reproductive axisKyeong Hoon Jeong
Harvard Medical School, Brigham and Women s Hospital, Division of Endocrinology, Diabetes and Hypertension, 221 Longwood Avenue, Boston, Massachusetts 02115, USA
Endocrinology 150:3383-91. 2009..We conclude that the expression of the TAg transgene driven by the GnRHR gene promoter results in female-specific infertility due to disruption of gonadotropin production and secretion even before tumor development... - Synergy between activin A and gonadotropin-releasing hormone in transcriptional activation of the rat follicle-stimulating hormone-beta geneSusan J Gregory
Brigham and Women s Hospital and Harvard Medical School, Division of Endocrinology, Diabetes and Hypertension, 221 Longwood Avenue, Boston, Massachusetts 02115, USA
Mol Endocrinol 19:237-54. 2005..The results indicate that SMAD3 plays an important role in the synergistic effects of activin and GnRH and demonstrate that this synergy is mediated by a palindromic cis-element located at -266/-259 of the rFSHbeta gene promoter... - Pituitary homeobox 1 activates the rat FSHbeta (rFSHbeta) gene through both direct and indirect interactions with the rFSHbeta gene promoterMarjorie M Zakaria
Endocrine Hypertension Division, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Mol Endocrinol 16:1840-52. 2002..These results identify a functional Ptx1 binding site in the rFSHbeta gene promoter and suggest the presence of an additional activating pathway that is independent of direct binding of Ptx1 to the promoter... - Oct-1 and nuclear factor Y bind to the SURG-1 element to direct basal and gonadotropin-releasing hormone (GnRH)-stimulated mouse GnRH receptor gene transcriptionKyung Yoon Kam
Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 221 Longwood Avenue, Boston, Massachusetts 02115, USA
Mol Endocrinol 19:148-62. 2005..In conclusion, NF-Y and Oct-1 bind to the SURG-1 element to direct basal and GnRH-stimulated expression of the mGnRHR gene... - Direct binding of AP-1 (Fos/Jun) proteins to a SMAD binding element facilitates both gonadotropin-releasing hormone (GnRH)- and activin-mediated transcriptional activation of the mouse GnRH receptor geneErrol R Norwitz
Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 277:37469-78. 2002.... - Reproductive hormone-dependent and -independent contributions to developmental changes in kisspeptin in GnRH-deficient hypogonadal miceJohn C Gill
Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
PLoS ONE 5:e11911. 2010.... - Human GnRH deficiency: a unique disease model to unravel the ontogeny of GnRH neuronsRavikumar Balasubramanian
Harvard Reproductive Endocrine Sciences Center of Excellence, Reproductive Endocrine Unit of the Department of Medicine of the Massachusetts General Hospital and Endocrine Division of the Brigham and Women s Hospital, Boston, MA 02114, USA
Neuroendocrinology 92:81-99. 2010..These insights now provide practicing clinicians with targeted genetic diagnostic strategies and also impact on clinical management... - A composite element that binds basic helix loop helix and basic leucine zipper transcription factors is important for gonadotropin-releasing hormone regulation of the follicle-stimulating hormone beta geneNick A Ciccone
Brigham and Women s Hospital, Division of Endocrinology, Diabetes and Hypertension, 221 Longwood Avenue, Boston, Massachusetts 0211, USA
Mol Endocrinol 22:1908-23. 2008..In conclusion, a composite element bound by both USF and CREB serves to integrate signals for basal and GnRH-stimulated transcription of the rat FSHbeta gene... - GNRHR mutations in a woman with idiopathic hypogonadotropic hypogonadism highlight the differential sensitivity of luteinizing hormone and follicle-stimulating hormone to gonadotropin-releasing hormoneAstrid U Meysing
Reproductive Endocrine Unit, Bartlett Hall Extension 5, Massachusetts General Hospital, Boston, MA 02114, USA
J Clin Endocrinol Metab 89:3189-98. 2004.... - Regulation of gonadotropin gene expression by Mullerian inhibiting substanceGregoy Y Bedecarrats
Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Proc Natl Acad Sci U S A 100:9348-53. 2003.... - Two common naturally occurring mutations in the human gonadotropin-releasing hormone (GnRH) receptor have differential effects on gonadotropin gene expression and on GnRH-mediated signal transductionGregoy Y Bedecarrats
Endocrine-Hypertension Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
J Clin Endocrinol Metab 88:834-43. 2003..The differential stimulation of LH beta, FSH beta, and alpha GSU gene expression may contribute to the varied phenotypes observed among patients harboring these mutations... - Differential regulation of gonadotropin subunit gene promoter activity by pulsatile gonadotropin-releasing hormone (GnRH) in perifused L beta T2 cells: role of GnRH receptor concentrationGregoy Y Bedecarrats
Endocrine Hypertension Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Endocrinology 144:1802-11. 2003..Furthermore, our studies indicate that cell-surface GnRHR density is a critical mediator of this differential regulation... - The biology of gonadotroph regulationNick A Ciccone
Division of Endocrinology, Diabetes and Hypertension, Brigham and Women s Hospital and Harvard Medical School, 221 Longwood Avenue, Boston, Massachusetts 02115, USA
Curr Opin Endocrinol Diabetes Obes 16:321-7. 2009.... - TAC3/TACR3 mutations reveal preferential activation of gonadotropin-releasing hormone release by neurokinin B in neonatal life followed by reversal in adulthoodElena Gianetti
Harvard Center for Reproductive Sciences and Reproductive Endocrine Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
J Clin Endocrinol Metab 95:2857-67. 2010.... - Impaired fibroblast growth factor receptor 1 signaling as a cause of normosmic idiopathic hypogonadotropic hypogonadismTaneli Raivio
Reproductive Endocrine Unit, Department of Medicine, The Harvard Center for Reproductive Endocrine Sciences, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
J Clin Endocrinol Metab 94:4380-90. 2009..FGFR1 mutations have been identified in about 10% of patients with Kallmann syndrome. Recently cases of idiopathic hypogonadotropic hypogonadism (IHH) with a normal sense of smell (nIHH) have been reported... - The gonadotropin-releasing hormone (GnRH) neuronal population is normal in size and distribution in GnRH-deficient and GnRH receptor-mutant hypogonadal miceJohn C Gill
Division of Endocrinology, Diabetes and Hypertension, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Endocrinology 149:4596-604. 2008..These data establish that autocrine-paracrine GnRH-signaling is not a prerequisite for the developmental migration of GnRH neurons into the brain or for the projection of GnRH neurosecretory axons... - Gonadotropin-releasing hormone pulse frequency-dependent activation of extracellular signal-regulated kinase pathways in perifused LbetaT2 cellsHaruhiko Kanasaki
Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Endocrinology 146:5503-13. 2005.... - Frequency-dependent regulation of follicle-stimulating hormone beta by pulsatile gonadotropin-releasing hormone is mediated by functional antagonism of bZIP transcription factorsNick A Ciccone
Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital, 221 Longwood Ave, Boston, MA 02115, USA
Mol Cell Biol 30:1028-40. 2010..These data suggest that ICER production antagonizes the stimulatory action of CREB to attenuate FSH beta transcription at high GnRH pulse frequencies, thereby playing a critical role in regulating cyclic reproductive function... 
Lymphocytic hypophysitis with diabetes insipidus in a young manOle Petter R Hamnvik
Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
Nat Rev Endocrinol 6:464-70. 2010..Subsequent scanning revealed a suprasellar mass, which demonstrated progressive enlargement on serial imaging. He also developed hypogonadotropic hypogonadism...- Human LSD2/KDM1b/AOF1 regulates gene transcription by modulating intragenic H3K4me2 methylationRui Fang
Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, Brigham and Women s Hospital, 221 Longwood Avenue, Boston, MA 02115, USA
Mol Cell 39:222-33. 2010..These data provide a possible molecular mechanism linking LSD2 to transcriptional regulation after initiation... - A GPR54-activating mutation in a patient with central precocious pubertyMilena Gurgel Teles
Developmental Endocrinology Unit, Medical Investigation Laboratory, Clinicas Hospital, Sao Paulo University Medical School, Sao Paulo
N Engl J Med 358:709-15. 2008..In vitro studies have shown that this mutation leads to prolonged activation of intracellular signaling pathways in response to kisspeptin. The Arg386Pro mutant appears to be associated with central precocious puberty... - Pubertal impairment in Nhlh2 null mice is associated with hypothalamic and pituitary deficienciesTiziana Cogliati
Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20889, USA
Mol Endocrinol 21:3013-27. 2007.... - Mutations in the human gonadotropin-releasing hormone receptor: insights into receptor biology and functionGregoy Y Bedecarrats
Department of Animal and Poultry Science, Ontario Agricultural College, University of Guelph, Guelph, Ontario, Canada
Semin Reprod Med 25:368-78. 2007..Furthermore, given that it was recently demonstrated that pharmacological chaperones can rescue altered receptor function in vitro, potential therapeutic approaches are also discussed...
Research Grants
- REPRODUCTIVE PHYSIOLOGY OF GONADOTROPIN SYNTHESISURSULA KAISER; Fiscal Year: 2009..abstract_text> ..
- GENE THERAPY FOR RESCUE OF REPRODUCTIVE FUNCTIONURSULA KAISER; Fiscal Year: 2006....
- REPRODUCTIVE BIOLOGY OF GONADOTROPIN REGULATIONURSULA KAISER; Fiscal Year: 2005..abstract_text> ..
- REPRODUCTIVE PHYSIOLOGY OF GONADOTROPIN SYNTHESISURSULA KAISER; Fiscal Year: 2002....
- Use of Gene Therapy: A Tool to Study Reproductive FunctionUrsula B Kaiser; Fiscal Year: 2010..abstract_text> ..