Kristopher T Kahle

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. doi request reprint Resolution of headache and papilledema in idiopathic intracranial hypertension associated with inhibition of Na+-K+-2Cl- cotransport
    Kristopher T Kahle
    Department of Neurosurgery, Harvard Medical School and Massachusetts General Hospital, Boston, MA 02114, USA
    J Child Neurol 26:205-8. 2011
  2. doi request reprint The bumetanide-sensitive Na-K-2Cl cotransporter NKCC1 as a potential target of a novel mechanism-based treatment strategy for neonatal seizures
    Kristopher T Kahle
    Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Neurosurg Focus 25:E22. 2008
  3. doi request reprint Roles of the cation-chloride cotransporters in neurological disease
    Kristopher T Kahle
    Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Nat Clin Pract Neurol 4:490-503. 2008
  4. doi request reprint Molecular mechanisms of ischemic cerebral edema: role of electroneutral ion transport
    Kristopher T Kahle
    Departments of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Physiology (Bethesda) 24:257-65. 2009
  5. doi request reprint A novel protein kinase signaling pathway essential for blood pressure regulation in humans
    Kristopher T Kahle
    Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Trends Endocrinol Metab 19:91-5. 2008
  6. pmc Bumetanide enhances phenobarbital efficacy in a rat model of hypoxic neonatal seizures
    Ryan T Cleary
    Department of Neurology, Children s Hospital Boston, Boston, Massachusetts, United States of America
    PLoS ONE 8:e57148. 2013
  7. pmc Craniectomy for malignant cerebral infarction: prevalence and outcomes in US hospitals
    Brian P Walcott
    Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 6:e29193. 2011
  8. pmc Phosphoregulation of the Na-K-2Cl and K-Cl cotransporters by the WNK kinases
    Kristopher T Kahle
    Department of Neurosurgery, Harvard Medical School, Boston, MA 02114, USA
    Biochim Biophys Acta 1802:1150-8. 2010
  9. pmc The use of intra-operative blood gas analysis in the investigation of suspected iatrogenic vascular injury
    Brian P Walcott
    Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
    Eur Spine J 21:S492-4. 2012
  10. doi request reprint Incidence of cerebrospinal fluid leak following petrosectomy and analysis of avoidance techniques
    Brian P Walcott
    Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Neurosci 19:92-4. 2012

Collaborators

Detail Information

Publications64

  1. doi request reprint Resolution of headache and papilledema in idiopathic intracranial hypertension associated with inhibition of Na+-K+-2Cl- cotransport
    Kristopher T Kahle
    Department of Neurosurgery, Harvard Medical School and Massachusetts General Hospital, Boston, MA 02114, USA
    J Child Neurol 26:205-8. 2011
    ....
  2. doi request reprint The bumetanide-sensitive Na-K-2Cl cotransporter NKCC1 as a potential target of a novel mechanism-based treatment strategy for neonatal seizures
    Kristopher T Kahle
    Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Neurosurg Focus 25:E22. 2008
    ....
  3. doi request reprint Roles of the cation-chloride cotransporters in neurological disease
    Kristopher T Kahle
    Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Nat Clin Pract Neurol 4:490-503. 2008
    ..CCCs represent attractive therapeutic targets in neurological disorders the pathogenesis of which involves deranged cellular chloride homoestasis...
  4. doi request reprint Molecular mechanisms of ischemic cerebral edema: role of electroneutral ion transport
    Kristopher T Kahle
    Departments of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Physiology (Bethesda) 24:257-65. 2009
    ..Combination pharmacological strategies that include NKCC1 as a target might thus prove beneficial for the treatment of ischemic, and potentially other types of, cerebral edema...
  5. doi request reprint A novel protein kinase signaling pathway essential for blood pressure regulation in humans
    Kristopher T Kahle
    Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Trends Endocrinol Metab 19:91-5. 2008
    ..The current evidence supports a model in which WNK4 coordinates the activities of diverse aldosterone-sensitive mediators of ion transport in the distal nephron to promote normal homeostasis in response to physiological perturbation...
  6. pmc Bumetanide enhances phenobarbital efficacy in a rat model of hypoxic neonatal seizures
    Ryan T Cleary
    Department of Neurology, Children s Hospital Boston, Boston, Massachusetts, United States of America
    PLoS ONE 8:e57148. 2013
    ..Taken together, these data provide preclinical support for clinical trials of bumetanide in human neonates at risk for hypoxic encephalopathy and seizures...
  7. pmc Craniectomy for malignant cerebral infarction: prevalence and outcomes in US hospitals
    Brian P Walcott
    Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 6:e29193. 2011
    ..Randomized trials have demonstrated the efficacy of craniectomy for the treatment of malignant cerebral edema following ischemic stroke. We sought to determine the prevalence and outcomes related to this by using a national database...
  8. pmc Phosphoregulation of the Na-K-2Cl and K-Cl cotransporters by the WNK kinases
    Kristopher T Kahle
    Department of Neurosurgery, Harvard Medical School, Boston, MA 02114, USA
    Biochim Biophys Acta 1802:1150-8. 2010
    ....
  9. pmc The use of intra-operative blood gas analysis in the investigation of suspected iatrogenic vascular injury
    Brian P Walcott
    Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
    Eur Spine J 21:S492-4. 2012
    ..Differentiating arterial from brisk venous bleeding would be ideal to assist in the intra-operative management. Definitive angiography is typically not feasible during most routine spine surgery...
  10. doi request reprint Incidence of cerebrospinal fluid leak following petrosectomy and analysis of avoidance techniques
    Brian P Walcott
    Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Neurosci 19:92-4. 2012
    ..CSF diversion and vascularized temporalis muscle flaps are effective in preventing the development of postoperative CSF leaks following petrosectomy...
  11. doi request reprint Chordoma: current concepts, management, and future directions
    Brian P Walcott
    Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Lancet Oncol 13:e69-76. 2012
    ..In this Review, we highlight current standards in diagnosis, clinical management, and molecular characterisation of chordomas, and discuss current research...
  12. doi request reprint The incidence of complications in elective cranial neurosurgery associated with dural closure material
    Brian P Walcott
    Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts and
    J Neurosurg 120:278-84. 2014
    ..Modifiable risk factors exist for craniotomy complications that warrant vigilance and further study. ..
  13. doi request reprint Pathological mechanism of lumbar disc herniation resulting in neurogenic muscle hypertrophy
    Brian P Walcott
    Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, 55 Fruit St, White Building Room 502, Boston, MA 02114, USA
    J Clin Neurosci 18:1682-4. 2011
    ..To our knowledge this is the first report of both grouped atrophy and compensatory hypertrophy of both muscle fiber types seen in this phenomenon...
  14. pmc Novel treatment targets for cerebral edema
    Brian P Walcott
    Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Neurotherapeutics 9:65-72. 2012
    ..A specific antagonist of the vasopressin V1A- and V2-receptor, conivaptan, promotes water excretion while sparing electrolytes through a process known as aquaresis...
  15. doi request reprint Dural scalp and intracranial hemangiomas causing hydrocephalus and venous sinus thrombosis in an infant
    Brian V Nahed
    Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    J Child Neurol 26:777-81. 2011
    ..Innocuous scalp hemangioma in an infant may herald more concerning intracranial pathology, which can be treated effectively if diagnosed with appropriate imaging studies...
  16. doi request reprint Induced and sustained hypernatremia for the prevention and treatment of cerebral edema following brain injury
    Justine H Ryu
    Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, White Building Room 502, Boston, MA, 02114, USA
    Neurocrit Care 19:222-31. 2013
    ..Insufficient evidence exists to recommend pharmacologic induction of hypernatremia as a treatment for cerebral edema. The strategy of vigilant avoidance of hyponatremia is currently a safer, potentially more efficacious paradigm. ..
  17. pmc Continuous hyperosmolar therapy for traumatic brain injury-associated cerebral edema: as good as it gets, or an iatrogenic secondary insult?
    Kristopher T Kahle
    Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Neurosci 20:30-1. 2013
    ..This practice is highly controversial, is in widespread use, and lacks robust evidence for efficacy. Herein, we review details of the controversy regarding this practice...
  18. doi request reprint Diagnostic pitfalls in spine surgery: masqueraders of surgical spine disease
    Brian P Walcott
    Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Neurosurg Focus 31:E1. 2011
    ..Awareness of these diagnoses can help reduce diagnostic error, thereby avoiding the morbidity and expense associated with an unnecessary operation...
  19. doi request reprint Hyponatremia associated with Ipilimumab-induced hypophysitis
    Zachary R Barnard
    Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, White Building Room 502, Boston, MA 02114, USA
    Med Oncol 29:374-7. 2012
    ..Effective treatment consisted of fluid restriction, hyperosmolar therapy, and steroids...
  20. pmc Interfacility helicopter ambulance transport of neurosurgical patients: observations, utilization, and outcomes from a quaternary level care hospital
    Brian P Walcott
    Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 6:e26216. 2011
    ..We sought to determine actual practice patterns, utilization, and outcomes of patients undergoing interfacility transport for neurosurgical conditions...
  21. doi request reprint Determinants of initial bone graft volume loss in posterolateral lumbar fusion
    Manish K Aghi
    Department of Neurosurgery, University of California, San Francisco, CA, USA
    J Clin Neurosci 18:1193-6. 2011
    ..We concluded that bone graft exhibited resorption 3 months postoperatively on both sides of all patients in this series, and that smoking was significantly associated with increased bone graft resorption...
  22. doi request reprint Role of NKCC1 and KCC2 in the development of chronic neuropathic pain following spinal cord injury
    Tera Hasbargen
    Department of Neurosurgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA
    Ann N Y Acad Sci 1198:168-72. 2010
    ..Thus, imbalanced function of NKCC1 and KCC2 may contribute to the induction and maintenance of the chronic neuropathic pain following SCI...
  23. doi request reprint Determination of geographic variance in stroke prevalence using Internet search engine analytics
    Brian P Walcott
    Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Neurosurg Focus 30:E19. 2011
    ..The authors hypothesized that the use of search engine query data can determine the prevalence of stroke...
  24. doi request reprint Surgical treatment and outcomes of metastatic breast cancer to the spine
    Brian P Walcott
    Department of Neurosurgery, Massachusetts General Hospital, 55 Fruit St, White Building Room 502, Boston, MA 02114, USA
    J Clin Neurosci 18:1336-9. 2011
    ..We concluded that aggressive therapy, including surgery, is warranted for patients with symptomatic metastatic epidural spinal cord compression from breast cancer, including in the setting of advanced and progressive systemic disease...
  25. doi request reprint Decreased seizure activity in a human neonate treated with bumetanide, an inhibitor of the Na(+)-K(+)-2Cl(-) cotransporter NKCC1
    Kristopher T Kahle
    Department of Neurosurgery, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Child Neurol 24:572-6. 2009
    ..These results suggest bumetanide may exert antiepileptic effects in human neonates...
  26. doi request reprint Early experience with flow diverting endoluminal stents for the treatment of intracranial aneurysms
    Brian P Walcott
    Department of Neurological Surgery, Massachusetts General Hospital and Harvard Medical School, White Building, Room 502, 55 Fruit Street, Boston, MA 02114, USA
    J Clin Neurosci 18:891-4. 2011
    ..Long-term efficacy, optimal antithrombotic agent regimen, and perforator stroke risk are yet to be determined...
  27. doi request reprint En bloc excision of a dermal sinus tract
    Jean Valery Coumans
    Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, WACC 745, 15 Parkman Street, Boston, MA 02114, USA
    J Clin Neurosci 18:554-8. 2011
    ..We conclude that en bloc excision of a dermal sinus tract down to the intradural space is feasible with modifications to standard operative technique...
  28. pmc Progressive NKCC1-dependent neuronal chloride accumulation during neonatal seizures
    Volodymyr I Dzhala
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Neurosci 30:11745-61. 2010
    ..This provides a potential mechanism for the early crescendo phase of neonatal seizures...
  29. pmc EGFR mutation status and survival after diagnosis of brain metastasis in nonsmall cell lung cancer
    April F Eichler
    Pappas Center for Neuro Oncology, Massachusetts General Hospital, 55 Fruit Street, Yawkey 9E, Boston, MA 02114, USA
    Neuro Oncol 12:1193-9. 2010
    ..70-6.41) were independently associated with survival. In NSCLC patients with BM, EGFR mutation status is associated with improved survival, independent of age, functional status, extracranial disease status, and number of BMs...
  30. pmc Inhibition of Na(+)-K(+)-2Cl(-) cotransporter isoform 1 accelerates temozolomide-mediated apoptosis in glioblastoma cancer cells
    Jehad Algharabil
    Department of Neurosurgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA
    Cell Physiol Biochem 30:33-48. 2012
    ..Therefore, blocking NKCC1 function augments TMZ-induced apoptosis in glioma cells...
  31. doi request reprint Steroid responsive A3243G mutation MELAS: clinical and radiographic evidence for regional hyperperfusion leading to neuronal loss
    Brian P Walcott
    Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Neurologist 18:159-70. 2012
    ....
  32. doi request reprint Cerebrovascular bypass and aneurysm trapping for the treatment of an A2-segment anterior cerebral artery pseudoaneurysm and herniation through a skull base defect following trauma
    Brian P Walcott
    Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, White Building Room 502, Boston, MA 0211H, USA
    J Clin Neurosci 19:149-51. 2012
    ..We present a unique case of a traumatic proximal anterior cerebral artery pseudoaneurysm, herniating through a skull base defect. Treatment consisted of aneurysm trapping and bypass with skull base reconstruction...
  33. pmc Deep brain stimulation for medically refractory life-threatening status dystonicus in children
    Brian P Walcott
    Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts, USA
    J Neurosurg Pediatr 9:99-102. 2012
    ..Bilateral globus pallidus internus stimulation appears to be effective in the urgent treatment of medically refractory and life-threatening movement disorders...
  34. doi request reprint Familial Chiari malformation: case series
    Benjamin D Schanker
    Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, 02114, USA
    Neurosurg Focus 31:E1. 2011
    ..Recent advances in the understanding of the genetic influences and pathogenesis of familial Chiari malformation are expected to improve management of affected patients and monitoring of at-risk family members...
  35. pmc Volumetric analysis of syringomyelia following hindbrain decompression for Chiari malformation Type I: syringomyelia resolution follows exponential kinetics
    Jean Valery Coumans
    Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Neurosurg Focus 31:E4. 2011
    ..Resolution of syringomyelia is common following hindbrain decompression for Chiari malformation, yet little is known about the kinetics governing this process. The authors sought to establish the volumetric rate of syringomyelia resolution...
  36. doi request reprint Diffuse central neurocytoma with craniospinal dissemination
    Christopher J Stapleton
    Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, White Building Room 502, Boston, MA, USA
    J Clin Neurosci 19:163-6. 2012
    ..At 18 months followup, the patient has completed 6 of 8 total cycles of vincristine and carboplatin and serial imaging shows stable disease within the craniospinal axis...
  37. pmc Trends in Peptic Ulcer Disease and the Identification of Helicobacter Pylori as a Causative Organism: Population-based Estimates from the US Nationwide Inpatient Sample
    Bronislava Bashinskaya
    Department of Biology, Boston University, Boston, USA
    J Glob Infect Dis 3:366-70. 2011
    ..We sought to determine trends related to this discovery by using a national database...
  38. doi request reprint Temporal bone chondroblastoma with secondary aneurysmal bone cyst presenting as an intracranial mass with clinical seizure activity
    Christopher J Stapleton
    Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Neurosci 18:857-60. 2011
    ..We review issues relevant to the pathology and treatment of these lesions...
  39. doi request reprint Diagnosis of acute lymphoblastic leukemia from intracerebral hemorrhage and blast crisis. A case report and review of the literature
    Matthew R Naunheim
    Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Clin Neurol Neurosurg 112:575-7. 2010
    ..This case demonstrates that the presence of hyperleukocytosis in a patient with intracerebral hemorrhage should raise clinical suspicion for acute leukemia as the cause of the ICH...
  40. pmc Cerebral edema and a transtentorial brain herniation syndrome associated with pandemic swine influenza A (H1N1) virus infection
    Kristopher T Kahle
    Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, White Building, Room 502, 55 Fruit Street, Boston, Massachusetts 02114, USA
    J Clin Neurosci 18:1245-8. 2011
    ....
  41. pmc Trends in inpatient setting laminectomy for excision of herniated intervertebral disc: Population-based estimates from the US nationwide inpatient sample
    Brian P Walcott
    Department of Neurological Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Surg Neurol Int 2:7. 2011
    ..Treatment for this condition is categorized as surgical or non-surgical. We sought to identify trends in inpatient surgical management of herniated intervertebral discs using a national database...
  42. pmc Managing malignant cerebral infarction
    J Marc Simard
    Department of Neurosurgery, University of Maryland School of Medicine, 22 S Greene St, Suite S12D, Baltimore, MD, 21201 1595, USA
    Curr Treat Options Neurol 13:217-29. 2011
    ..Under appropriate circumstances, decompressive craniectomy may be warranted to improve outcome or to prevent death...
  43. pmc Molecular mechanisms of microvascular failure in central nervous system injury--synergistic roles of NKCC1 and SUR1/TRPM4
    J Marc Simard
    Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland 21201 1595, USA
    J Neurosurg 113:622-9. 2010
    ....
  44. doi request reprint Endoscopic burr hole evacuation of an acute subdural hematoma
    Patrick J Codd
    Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, WHT 502, Boston, MA 02114 2698, USA Electronic address
    J Clin Neurosci 20:1751-3. 2013
    ..The operative approach is outlined, and the literature on endoscopic subdural collection evacuation reviewed. ..
  45. doi request reprint Interval, acute onset airway obstruction associated with a fracture of the C4 vertebra in a patient with ankylosing spondylitis
    Brian V Nahed
    Department of Neurosurgery, Massachusetts General Hospital, 15 Parkman Street, Boston, Massachusetts 02114 3117, USA
    J Clin Neurosci 17:1085-8. 2010
    ..This example highlights one of the potential complications of rigid cervical collar immobilization in patients with spinal instability...
  46. doi request reprint Intracranial vasospasm with subsequent stroke after traumatic subarachnoid hemorrhage in a 22-month-old child
    Brian V Nahed
    Department of Neurosurgery, Massachusetts General Hospital, USA
    J Neurosurg Pediatr 3:311-5. 2009
    ..Thus, clinicians need to be alert to the possibility of vasospasm as a potential diagnosis when evaluating young children with SAH...
  47. ncbi request reprint Hypertension, age, and location predict rupture of small intracranial aneurysms
    Brian V Nahed
    Department of Neurosurgery, Yale Brain Aneurysm and AVM Center, Yale University School of Medicine, New Haven, Connecticut, USA
    Neurosurgery 57:676-83; discussion 676-83. 2005
    ..Thus, we sought to identify risk factors associated with the rupture of IAs 7 mm or smaller...
  48. pmc WNK3, a kinase related to genes mutated in hereditary hypertension with hyperkalaemia, regulates the K+ channel ROMK1 (Kir1.1)
    Qiang Leng
    Department of Molecular and Cellular Physiology, Yale University School of Medicine, New Haven, CT 06510, USA
    J Physiol 571:275-86. 2006
    ..WNK3 is likely a component of one of the mechanisms that determines the balance between renal NaCl reabsorption and K+ secretion...
  49. pmc Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4
    Frederick H Wilson
    Department of Genetics, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 100:680-4. 2003
    ..Together, these findings demonstrate that WNK4 negatively regulates surface expression of NCCT and implicate loss of this regulation in the molecular pathogenesis of an inherited form of hypertension...
  50. pmc WNK4 regulates activity of the epithelial Na+ channel in vitro and in vivo
    Aaron M Ring
    Departments of Genetics, Medicine, and Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 104:4020-4. 2007
    ..These findings support a key role for WNK4 in coordinating the activities of diverse flux pathways to achieve integrated fluid and electrolyte homeostasis...
  51. ncbi request reprint WNK protein kinases modulate cellular Cl- flux by altering the phosphorylation state of the Na-K-Cl and K-Cl cotransporters
    Kristopher T Kahle
    Howard Hughes Medical Institute, Department of Genetics, Yale University School of Medicine, New Haven, Connecticut, USA
    Physiology (Bethesda) 21:326-35. 2006
    ....
  52. pmc Regulation of NKCC2 by a chloride-sensing mechanism involving the WNK3 and SPAK kinases
    Jose Ponce-Coria
    Molecular Physiology Unit, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán and Instituto de Investigaciones Biomédicas, Universidad Nacional Autonoma de Mexico, Tlalpan, 14000 Mexico City, Mexico
    Proc Natl Acad Sci U S A 105:8458-63. 2008
    ....
  53. pmc WNK1, a kinase mutated in inherited hypertension with hyperkalemia, localizes to diverse Cl- -transporting epithelia
    Keith A Choate
    Department of Genetics, Howard Hughes Medical Institute, Yale University School of Medicine, 295 Congress Avenue, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 100:663-8. 2003
    ....
  54. ncbi request reprint WNK4 regulates the balance between renal NaCl reabsorption and K+ secretion
    Kristopher T Kahle
    Howard Hughes Medical Institute, 300 Cedar Street, TAC S 341D, and Department of Genetics, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Nat Genet 35:372-6. 2003
    ..They also identify WNK4 as a molecular switch that can vary the balance between NaCl reabsorption and K+ secretion to maintain integrated homeostasis...
  55. pmc WNK4 regulates apical and basolateral Cl- flux in extrarenal epithelia
    Kristopher T Kahle
    Department of Genetics, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 101:2064-9. 2004
    ..Moreover, they reveal that WNK4 regulates the activities of a diverse group of structurally unrelated ion channels, cotransporters, and exchangers...
  56. ncbi request reprint WNK kinases: molecular regulators of integrated epithelial ion transport
    Kristopher T Kahle
    Department of Genetics and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Curr Opin Nephrol Hypertens 13:557-62. 2004
    ..This review focuses on the recent evidence elucidating the functions of these kinases in normal and disease physiology...
  57. pmc Paracellular Cl- permeability is regulated by WNK4 kinase: insight into normal physiology and hypertension
    Kristopher T Kahle
    Department of Genetics, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 101:14877-82. 2004
    ....
  58. ncbi request reprint Regulation of diverse ion transport pathways by WNK4 kinase: a novel molecular switch
    Kristopher T Kahle
    Departments of Genetics, Medicine, Molecular Biophysics and Biochemistry and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA
    Trends Endocrinol Metab 16:98-103. 2005
    ..WNK kinases are components of a novel signaling pathway that is important for the control of blood pressure and electrolyte homeostasis...
  59. pmc WNK3 modulates transport of Cl- in and out of cells: implications for control of cell volume and neuronal excitability
    Kristopher T Kahle
    Department of Genetics, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 102:16783-8. 2005
    ..They suggest that WNK3 is part of the Cl(-)/volume-sensing mechanism necessary for the maintenance of cell volume during osmotic stress and the dynamic modulation of GABA neurotransmission...
  60. ncbi request reprint Molecular physiology of the WNK kinases
    Kristopher T Kahle
    Howard Hughes Medical Institute, Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA
    Annu Rev Physiol 70:329-55. 2008
    ..These findings define a versatile new family of kinases that coordinate the activities of diverse ion transport pathways to achieve and maintain fluid and electrolyte homeostasis...
  61. pmc WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl- cotransporters required for normal blood pressure homeostasis
    Jesse Rinehart
    Department of Genetics, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 102:16777-82. 2005
    ..The effects of WNK3 on these transporters and their coexpression in renal epithelia implicate WNK3 in NaCl, water, and blood pressure homeostasis, perhaps via signaling downstream of vasopressin...
  62. pmc An SGK1 site in WNK4 regulates Na+ channel and K+ channel activity and has implications for aldosterone signaling and K+ homeostasis
    Aaron M Ring
    Departments of Genetics, Medicine, and Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 104:4025-9. 2007
    ..Together, the different states of WNK4 allow the kidney to provide distinct and appropriate integrated responses to intravascular volume depletion and hyperkalemia...
  63. ncbi request reprint Wnk4 controls blood pressure and potassium homeostasis via regulation of mass and activity of the distal convoluted tubule
    Maria D Lalioti
    Department of Genetics, Howard Hughes Medical, Institute, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nat Genet 38:1124-32. 2006
    ..These findings establish that Wnk4 is a molecular switch that regulates the balance between NaCl reabsorption and K+ secretion by altering the mass and function of the DCT through its effect on NCC...
  64. pmc WNK3 bypasses the tonicity requirement for K-Cl cotransporter activation via a phosphatase-dependent pathway
    Paola de los Heros
    Molecular Physiology Unit, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán and Instituto de Investigaciones Biomédicas, Universidad Nacional Autonoma de Mexico, Tlalpan, Mexico City, 14000, Mexico
    Proc Natl Acad Sci U S A 103:1976-81. 2006
    ....