Research Topics
| Kristopher T KahleSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
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Detail Information
Publications
Resolution of headache and papilledema in idiopathic intracranial hypertension associated with inhibition of Na+-K+-2Cl- cotransportKristopher T Kahle
Department of Neurosurgery, Harvard Medical School and Massachusetts General Hospital, Boston, MA 02114, USA
J Child Neurol 26:205-8. 2011....- Molecular mechanisms of ischemic cerebral edema: role of electroneutral ion transportKristopher T Kahle
Departments of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
Physiology (Bethesda) 24:257-65. 2009..Combination pharmacological strategies that include NKCC1 as a target might thus prove beneficial for the treatment of ischemic, and potentially other types of, cerebral edema... - Roles of the cation-chloride cotransporters in neurological diseaseKristopher T Kahle
Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Nat Clin Pract Neurol 4:490-503. 2008..CCCs represent attractive therapeutic targets in neurological disorders the pathogenesis of which involves deranged cellular chloride homoestasis... - The bumetanide-sensitive Na-K-2Cl cotransporter NKCC1 as a potential target of a novel mechanism-based treatment strategy for neonatal seizuresKristopher T Kahle
Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
Neurosurg Focus 25:E22. 2008.... - A novel protein kinase signaling pathway essential for blood pressure regulation in humansKristopher T Kahle
Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Trends Endocrinol Metab 19:91-5. 2008..The current evidence supports a model in which WNK4 coordinates the activities of diverse aldosterone-sensitive mediators of ion transport in the distal nephron to promote normal homeostasis in response to physiological perturbation... 
Craniectomy for malignant cerebral infarction: prevalence and outcomes in US hospitalsBrian P Walcott
Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
PLoS ONE 6:e29193. 2011..Randomized trials have demonstrated the efficacy of craniectomy for the treatment of malignant cerebral edema following ischemic stroke. We sought to determine the prevalence and outcomes related to this by using a national database...- Phosphoregulation of the Na-K-2Cl and K-Cl cotransporters by the WNK kinasesKristopher T Kahle
Department of Neurosurgery, Harvard Medical School, Boston, MA 02114, USA
Biochim Biophys Acta 1802:1150-8. 2010.... - The use of intra-operative blood gas analysis in the investigation of suspected iatrogenic vascular injuryBrian P Walcott
Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
Eur Spine J 21:S492-4. 2012..Differentiating arterial from brisk venous bleeding would be ideal to assist in the intra-operative management. Definitive angiography is typically not feasible during most routine spine surgery... - Incidence of cerebrospinal fluid leak following petrosectomy and analysis of avoidance techniquesBrian P Walcott
Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
J Clin Neurosci 19:92-4. 2012..CSF diversion and vascularized temporalis muscle flaps are effective in preventing the development of postoperative CSF leaks following petrosectomy... - Chordoma: current concepts, management, and future directionsBrian P Walcott
Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Lancet Oncol 13:e69-76. 2012..In this Review, we highlight current standards in diagnosis, clinical management, and molecular characterisation of chordomas, and discuss current research... - Pathological mechanism of lumbar disc herniation resulting in neurogenic muscle hypertrophyBrian P Walcott
Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, 55 Fruit St, White Building Room 502, Boston, MA 02114, USA
J Clin Neurosci 18:1682-4. 2011..To our knowledge this is the first report of both grouped atrophy and compensatory hypertrophy of both muscle fiber types seen in this phenomenon... - Novel treatment targets for cerebral edemaBrian P Walcott
Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Neurotherapeutics 9:65-72. 2012..A specific antagonist of the vasopressin V1A- and V2-receptor, conivaptan, promotes water excretion while sparing electrolytes through a process known as aquaresis... - Dural scalp and intracranial hemangiomas causing hydrocephalus and venous sinus thrombosis in an infantBrian V Nahed
Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
J Child Neurol 26:777-81. 2011..Innocuous scalp hemangioma in an infant may herald more concerning intracranial pathology, which can be treated effectively if diagnosed with appropriate imaging studies... - Diagnostic pitfalls in spine surgery: masqueraders of surgical spine diseaseBrian P Walcott
Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
Neurosurg Focus 31:E1. 2011..Awareness of these diagnoses can help reduce diagnostic error, thereby avoiding the morbidity and expense associated with an unnecessary operation... - Interfacility helicopter ambulance transport of neurosurgical patients: observations, utilization, and outcomes from a quaternary level care hospitalBrian P Walcott
Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
PLoS ONE 6:e26216. 2011..We sought to determine actual practice patterns, utilization, and outcomes of patients undergoing interfacility transport for neurosurgical conditions... - Hyponatremia associated with Ipilimumab-induced hypophysitisZachary R Barnard
Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, White Building Room 502, Boston, MA 02114, USA
Med Oncol 29:374-7. 2012..Effective treatment consisted of fluid restriction, hyperosmolar therapy, and steroids... - Determinants of initial bone graft volume loss in posterolateral lumbar fusionManish K Aghi
Department of Neurosurgery, University of California, San Francisco, CA, USA
J Clin Neurosci 18:1193-6. 2011..We concluded that bone graft exhibited resorption 3 months postoperatively on both sides of all patients in this series, and that smoking was significantly associated with increased bone graft resorption... - Role of NKCC1 and KCC2 in the development of chronic neuropathic pain following spinal cord injuryTera Hasbargen
Department of Neurosurgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA
Ann N Y Acad Sci 1198:168-72. 2010..Thus, imbalanced function of NKCC1 and KCC2 may contribute to the induction and maintenance of the chronic neuropathic pain following SCI... - Progressive NKCC1-dependent neuronal chloride accumulation during neonatal seizuresVolodymyr I Dzhala
Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
J Neurosci 30:11745-61. 2010..This provides a potential mechanism for the early crescendo phase of neonatal seizures... - En bloc excision of a dermal sinus tractJean Valery Coumans
Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, WACC 745, 15 Parkman Street, Boston, MA 02114, USA
J Clin Neurosci 18:554-8. 2011..We conclude that en bloc excision of a dermal sinus tract down to the intradural space is feasible with modifications to standard operative technique... - Surgical treatment and outcomes of metastatic breast cancer to the spineBrian P Walcott
Department of Neurosurgery, Massachusetts General Hospital, 55 Fruit St, White Building Room 502, Boston, MA 02114, USA
J Clin Neurosci 18:1336-9. 2011..We concluded that aggressive therapy, including surgery, is warranted for patients with symptomatic metastatic epidural spinal cord compression from breast cancer, including in the setting of advanced and progressive systemic disease... - Determination of geographic variance in stroke prevalence using Internet search engine analyticsBrian P Walcott
Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
Neurosurg Focus 30:E19. 2011..The authors hypothesized that the use of search engine query data can determine the prevalence of stroke... - Early experience with flow diverting endoluminal stents for the treatment of intracranial aneurysmsBrian P Walcott
Department of Neurological Surgery, Massachusetts General Hospital and Harvard Medical School, White Building, Room 502, 55 Fruit Street, Boston, MA 02114, USA
J Clin Neurosci 18:891-4. 2011..Long-term efficacy, optimal antithrombotic agent regimen, and perforator stroke risk are yet to be determined... - Decreased seizure activity in a human neonate treated with bumetanide, an inhibitor of the Na(+)-K(+)-2Cl(-) cotransporter NKCC1Kristopher T Kahle
Department of Neurosurgery, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
J Child Neurol 24:572-6. 2009..These results suggest bumetanide may exert antiepileptic effects in human neonates... - EGFR mutation status and survival after diagnosis of brain metastasis in nonsmall cell lung cancerApril F Eichler
Pappas Center for Neuro Oncology, Massachusetts General Hospital, 55 Fruit Street, Yawkey 9E, Boston, MA 02114, USA
Neuro Oncol 12:1193-9. 2010..70-6.41) were independently associated with survival. In NSCLC patients with BM, EGFR mutation status is associated with improved survival, independent of age, functional status, extracranial disease status, and number of BMs... - Inhibition of Na(+)-K(+)-2Cl(-) cotransporter isoform 1 accelerates temozolomide-mediated apoptosis in glioblastoma cancer cellsJehad Algharabil
Department of Neurosurgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA
Cell Physiol Biochem 30:33-48. 2012..Therefore, blocking NKCC1 function augments TMZ-induced apoptosis in glioma cells... - Steroid responsive A3243G mutation MELAS: clinical and radiographic evidence for regional hyperperfusion leading to neuronal lossBrian P Walcott
Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Neurologist 18:159-70. 2012.... - Cerebrovascular bypass and aneurysm trapping for the treatment of an A2-segment anterior cerebral artery pseudoaneurysm and herniation through a skull base defect following traumaBrian P Walcott
Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, White Building Room 502, Boston, MA 0211H, USA
J Clin Neurosci 19:149-51. 2012..We present a unique case of a traumatic proximal anterior cerebral artery pseudoaneurysm, herniating through a skull base defect. Treatment consisted of aneurysm trapping and bypass with skull base reconstruction... - Deep brain stimulation for medically refractory life-threatening status dystonicus in childrenBrian P Walcott
Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts, USA
J Neurosurg Pediatr 9:99-102. 2012..Bilateral globus pallidus internus stimulation appears to be effective in the urgent treatment of medically refractory and life-threatening movement disorders... - Cerebral edema and a transtentorial brain herniation syndrome associated with pandemic swine influenza A (H1N1) virus infectionKristopher T Kahle
Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, White Building, Room 502, 55 Fruit Street, Boston, Massachusetts 02114, USA
J Clin Neurosci 18:1245-8. 2011.... - Familial Chiari malformation: case seriesBenjamin D Schanker
Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, 02114, USA
Neurosurg Focus 31:E1. 2011..Recent advances in the understanding of the genetic influences and pathogenesis of familial Chiari malformation are expected to improve management of affected patients and monitoring of at-risk family members... - Volumetric analysis of syringomyelia following hindbrain decompression for Chiari malformation Type I: syringomyelia resolution follows exponential kineticsJean Valery Coumans
Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
Neurosurg Focus 31:E4. 2011..Resolution of syringomyelia is common following hindbrain decompression for Chiari malformation, yet little is known about the kinetics governing this process. The authors sought to establish the volumetric rate of syringomyelia resolution... - Diffuse central neurocytoma with craniospinal disseminationChristopher J Stapleton
Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, White Building Room 502, Boston, MA, USA
J Clin Neurosci 19:163-6. 2012..At 18 months followup, the patient has completed 6 of 8 total cycles of vincristine and carboplatin and serial imaging shows stable disease within the craniospinal axis... - Trends in Peptic Ulcer Disease and the Identification of Helicobacter Pylori as a Causative Organism: Population-based Estimates from the US Nationwide Inpatient SampleBronislava Bashinskaya
Department of Biology, Boston University, Boston, USA
J Glob Infect Dis 3:366-70. 2011..We sought to determine trends related to this discovery by using a national database... - Diagnosis of acute lymphoblastic leukemia from intracerebral hemorrhage and blast crisis. A case report and review of the literatureMatthew R Naunheim
Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Clin Neurol Neurosurg 112:575-7. 2010..This case demonstrates that the presence of hyperleukocytosis in a patient with intracerebral hemorrhage should raise clinical suspicion for acute leukemia as the cause of the ICH... - Temporal bone chondroblastoma with secondary aneurysmal bone cyst presenting as an intracranial mass with clinical seizure activityChristopher J Stapleton
Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
J Clin Neurosci 18:857-60. 2011..We review issues relevant to the pathology and treatment of these lesions... - Continuous hyperosmolar therapy for traumatic brain injury-associated cerebral edema: as good as it gets, or an iatrogenic secondary insult?Kristopher T Kahle
Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
J Clin Neurosci 20:30-1. 2013..This practice is highly controversial, is in widespread use, and lacks robust evidence for efficacy. Herein, we review details of the controversy regarding this practice... - Managing malignant cerebral infarctionJ Marc Simard
Department of Neurosurgery, University of Maryland School of Medicine, 22 S Greene St, Suite S12D, Baltimore, MD, 21201 1595, USA
Curr Treat Options Neurol 13:217-29. 2011..Under appropriate circumstances, decompressive craniectomy may be warranted to improve outcome or to prevent death... - Molecular mechanisms of microvascular failure in central nervous system injury--synergistic roles of NKCC1 and SUR1/TRPM4J Marc Simard
Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland 21201 1595, USA
J Neurosurg 113:622-9. 2010.... - Trends in inpatient setting laminectomy for excision of herniated intervertebral disc: Population-based estimates from the US nationwide inpatient sampleBrian P Walcott
Department of Neurological Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Surg Neurol Int 2:7. 2011..Treatment for this condition is categorized as surgical or non-surgical. We sought to identify trends in inpatient surgical management of herniated intervertebral discs using a national database... - Intracranial vasospasm with subsequent stroke after traumatic subarachnoid hemorrhage in a 22-month-old childBrian V Nahed
Department of Neurosurgery, Massachusetts General Hospital, USA
J Neurosurg Pediatr 3:311-5. 2009..Thus, clinicians need to be alert to the possibility of vasospasm as a potential diagnosis when evaluating young children with SAH... 
Hypertension, age, and location predict rupture of small intracranial aneurysmsBrian V Nahed
Department of Neurosurgery, Yale Brain Aneurysm and AVM Center, Yale University School of Medicine, New Haven, Connecticut, USA
Neurosurgery 57:676-83; discussion 676-83. 2005....- Interval, acute onset airway obstruction associated with a fracture of the C4 vertebra in a patient with ankylosing spondylitisBrian V Nahed
Department of Neurosurgery, Massachusetts General Hospital, 15 Parkman Street, Boston, Massachusetts 02114 3117, USA
J Clin Neurosci 17:1085-8. 2010..This example highlights one of the potential complications of rigid cervical collar immobilization in patients with spinal instability... - Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4Frederick H Wilson
Department of Genetics, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA
Proc Natl Acad Sci U S A 100:680-4. 2003..Together, these findings demonstrate that WNK4 negatively regulates surface expression of NCCT and implicate loss of this regulation in the molecular pathogenesis of an inherited form of hypertension... - WNK4 regulates activity of the epithelial Na+ channel in vitro and in vivoAaron M Ring
Departments of Genetics, Medicine, and Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA
Proc Natl Acad Sci U S A 104:4020-4. 2007..These findings support a key role for WNK4 in coordinating the activities of diverse flux pathways to achieve integrated fluid and electrolyte homeostasis... - WNK3, a kinase related to genes mutated in hereditary hypertension with hyperkalaemia, regulates the K+ channel ROMK1 (Kir1.1)Qiang Leng
Department of Molecular and Cellular Physiology, Yale University School of Medicine, New Haven, CT 06510, USA
J Physiol 571:275-86. 2006..WNK3 is likely a component of one of the mechanisms that determines the balance between renal NaCl reabsorption and K+ secretion... - Regulation of NKCC2 by a chloride-sensing mechanism involving the WNK3 and SPAK kinasesJose Ponce-Coria
Molecular Physiology Unit, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán and Instituto de Investigaciones Biomédicas, Universidad Nacional Autonoma de Mexico, Tlalpan, 14000 Mexico City, Mexico
Proc Natl Acad Sci U S A 105:8458-63. 2008.... - WNK1, a kinase mutated in inherited hypertension with hyperkalemia, localizes to diverse Cl- -transporting epitheliaKeith A Choate
Department of Genetics, Howard Hughes Medical Institute, Yale University School of Medicine, 295 Congress Avenue, New Haven, CT 06510, USA
Proc Natl Acad Sci U S A 100:663-8. 2003.... - WNK4 regulates the balance between renal NaCl reabsorption and K+ secretionKristopher T Kahle
Howard Hughes Medical Institute, 300 Cedar Street, TAC S 341D, and Department of Genetics, Yale University School of Medicine, New Haven, Connecticut 06510, USA
Nat Genet 35:372-6. 2003..They also identify WNK4 as a molecular switch that can vary the balance between NaCl reabsorption and K+ secretion to maintain integrated homeostasis... - WNK4 regulates apical and basolateral Cl- flux in extrarenal epitheliaKristopher T Kahle
Department of Genetics, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA
Proc Natl Acad Sci U S A 101:2064-9. 2004..Moreover, they reveal that WNK4 regulates the activities of a diverse group of structurally unrelated ion channels, cotransporters, and exchangers... - Molecular physiology of the WNK kinasesKristopher T Kahle
Howard Hughes Medical Institute, Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA
Annu Rev Physiol 70:329-55. 2008..These findings define a versatile new family of kinases that coordinate the activities of diverse ion transport pathways to achieve and maintain fluid and electrolyte homeostasis... - WNK3 bypasses the tonicity requirement for K-Cl cotransporter activation via a phosphatase-dependent pathwayPaola de los Heros
Molecular Physiology Unit, , , Tlalpan, Mexico City, 14000, Mexico
Proc Natl Acad Sci U S A 103:1976-81. 2006.... - WNK protein kinases modulate cellular Cl- flux by altering the phosphorylation state of the Na-K-Cl and K-Cl cotransportersKristopher T Kahle
Howard Hughes Medical Institute, Department of Genetics, Yale University School of Medicine, New Haven, Connecticut, USA
Physiology (Bethesda) 21:326-35. 2006.... - WNK3 modulates transport of Cl- in and out of cells: implications for control of cell volume and neuronal excitabilityKristopher T Kahle
Department of Genetics, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA
Proc Natl Acad Sci U S A 102:16783-8. 2005..They suggest that WNK3 is part of the Cl(-)/volume-sensing mechanism necessary for the maintenance of cell volume during osmotic stress and the dynamic modulation of GABA neurotransmission... - An SGK1 site in WNK4 regulates Na+ channel and K+ channel activity and has implications for aldosterone signaling and K+ homeostasisAaron M Ring
Departments of Genetics, Medicine, and Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA
Proc Natl Acad Sci U S A 104:4025-9. 2007..Together, the different states of WNK4 allow the kidney to provide distinct and appropriate integrated responses to intravascular volume depletion and hyperkalemia... - Regulation of diverse ion transport pathways by WNK4 kinase: a novel molecular switchKristopher T Kahle
Departments of Genetics, Medicine, Molecular Biophysics and Biochemistry and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA
Trends Endocrinol Metab 16:98-103. 2005..WNK kinases are components of a novel signaling pathway that is important for the control of blood pressure and electrolyte homeostasis... - Paracellular Cl- permeability is regulated by WNK4 kinase: insight into normal physiology and hypertensionKristopher T Kahle
Department of Genetics, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA
Proc Natl Acad Sci U S A 101:14877-82. 2004.... - WNK kinases: molecular regulators of integrated epithelial ion transportKristopher T Kahle
Department of Genetics and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06510, USA
Curr Opin Nephrol Hypertens 13:557-62. 2004..Their function has implications for understanding the coordinated regulation of electrolyte homeostasis and blood pressure, and identifies WNKs as dynamic regulators of the paracellular flux pathway... - Wnk4 controls blood pressure and potassium homeostasis via regulation of mass and activity of the distal convoluted tubuleMaria D Lalioti
Department of Genetics, Howard Hughes Medical, Institute, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Nat Genet 38:1124-32. 2006..These findings establish that Wnk4 is a molecular switch that regulates the balance between NaCl reabsorption and K+ secretion by altering the mass and function of the DCT through its effect on NCC... - WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl- cotransporters required for normal blood pressure homeostasisJesse Rinehart
Department of Genetics, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA
Proc Natl Acad Sci U S A 102:16777-82. 2005..The effects of WNK3 on these transporters and their coexpression in renal epithelia implicate WNK3 in NaCl, water, and blood pressure homeostasis, perhaps via signaling downstream of vasopressin...