R M Kacmarek

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc Ventilatory management of ARDS: high frequency oscillation and lung recruitment!
    Robert M Kacmarek
    Harvard Medical School and Respiratory Care, Massachusetts General Hospital, Ellison 401, 55 Fruit Street, Boston MA, USA
    Crit Care 10:158. 2006
  2. ncbi request reprint Complications of tracheal gas insufflation
    R M Kacmarek
    Department of Respiratory Care, Ellison 401, Massachusetts General Hospital, 55 Fruit Street, Boston MA 02114 2696, USA
    Respir Care 46:167-76. 2001
  3. ncbi request reprint Partial liquid ventilation in adult patients with acute respiratory distress syndrome
    Robert M Kacmarek
    Department of Anesthesia and Critical Care, Harvard Medical School, and Respiratory Care, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Respir Crit Care Med 173:882-9. 2006
  4. ncbi request reprint Lung recruitment in patients with ARDS
    Robert M Kacmarek
    N Engl J Med 355:320; author reply 321-2. 2006
  5. doi request reprint Last word on point:counterpoint: High-frequency ventilation is/is not the optimal physiological approach to ventilate ARDS patients
    Robert M Kacmarek
    J Appl Physiol 104:1241. 2008
  6. ncbi request reprint Management of refractory hypoxemia in ARDS
    R M Kacmarek
    Department of Respiratory Care, Massachusetts General Hospital, Boston, MA, USA
    Minerva Anestesiol 79:1173-9. 2013
  7. doi request reprint Mechanical ventilation competencies of the respiratory therapist in 2015 and Beyond
    Robert M Kacmarek
    Department of Anesthesiology, Harvard Medical School, Massachusetts General Hospital, Boston Massachusetts, USA
    Respir Care 58:1087-96. 2013
  8. doi request reprint Survey of directors of respiratory therapy departments regarding the future education and credentialing of respiratory care students and staff
    Robert M Kacmarek
    Respiratory Care Services, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 01460, USA
    Respir Care 57:710-20. 2012
  9. pmc Mechanical ventilation modulates TLR4 and IRAK-3 in a non-infectious, ventilator-induced lung injury model
    Jesus Villar
    CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Spain
    Respir Res 11:27. 2010
  10. doi request reprint Counterpoint: High-frequency ventilation is not the optimal physiological approach to ventilate ARDS patients
    Robert M Kacmarek
    Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA
    J Appl Physiol 104:1232-3; discussion 1233-5. 2008

Collaborators

Detail Information

Publications70

  1. pmc Ventilatory management of ARDS: high frequency oscillation and lung recruitment!
    Robert M Kacmarek
    Harvard Medical School and Respiratory Care, Massachusetts General Hospital, Ellison 401, 55 Fruit Street, Boston MA, USA
    Crit Care 10:158. 2006
    ..The key to managing ARDS regardless of mode is to use an open lung protective ventilatory strategy. It is not the mode that makes the difference, it is the approach used to apply the mode!..
  2. ncbi request reprint Complications of tracheal gas insufflation
    R M Kacmarek
    Department of Respiratory Care, Ellison 401, Massachusetts General Hospital, 55 Fruit Street, Boston MA 02114 2696, USA
    Respir Care 46:167-76. 2001
    ..As a result of the potential complications of TGI, this technique cannot be recommended for routine use until commercial systems are available...
  3. ncbi request reprint Partial liquid ventilation in adult patients with acute respiratory distress syndrome
    Robert M Kacmarek
    Department of Anesthesia and Critical Care, Harvard Medical School, and Respiratory Care, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Respir Crit Care Med 173:882-9. 2006
    ..Partial liquid ventilation (PLV) using perfluorocarbons has been shown to improve oxygenation and decrease lung injury in various animal models...
  4. ncbi request reprint Lung recruitment in patients with ARDS
    Robert M Kacmarek
    N Engl J Med 355:320; author reply 321-2. 2006
  5. doi request reprint Last word on point:counterpoint: High-frequency ventilation is/is not the optimal physiological approach to ventilate ARDS patients
    Robert M Kacmarek
    J Appl Physiol 104:1241. 2008
  6. ncbi request reprint Management of refractory hypoxemia in ARDS
    R M Kacmarek
    Department of Respiratory Care, Massachusetts General Hospital, Boston, MA, USA
    Minerva Anestesiol 79:1173-9. 2013
    ..We also find that there is now sufficient evidence to recommend against the use of high frequency oscillation in the management of refractory hypoxemia. ..
  7. doi request reprint Mechanical ventilation competencies of the respiratory therapist in 2015 and Beyond
    Robert M Kacmarek
    Department of Anesthesiology, Harvard Medical School, Massachusetts General Hospital, Boston Massachusetts, USA
    Respir Care 58:1087-96. 2013
    ..To achieve these levels of competency, as recommended by the third "2015 and Beyond" conference, the entry level education of the respiratory therapist of the future must be at the baccalaureate level...
  8. doi request reprint Survey of directors of respiratory therapy departments regarding the future education and credentialing of respiratory care students and staff
    Robert M Kacmarek
    Respiratory Care Services, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 01460, USA
    Respir Care 57:710-20. 2012
    ....
  9. pmc Mechanical ventilation modulates TLR4 and IRAK-3 in a non-infectious, ventilator-induced lung injury model
    Jesus Villar
    CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Spain
    Respir Res 11:27. 2010
    ....
  10. doi request reprint Counterpoint: High-frequency ventilation is not the optimal physiological approach to ventilate ARDS patients
    Robert M Kacmarek
    Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA
    J Appl Physiol 104:1232-3; discussion 1233-5. 2008
  11. ncbi request reprint Respiratory controversies in the critical care setting. Should recruitment maneuvers be used in the management of ALI and ARDS?
    Robert M Kacmarek
    Respiratory Care Services, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA
    Respir Care 52:622-31; discussion 631-5. 2007
    ..We explore both sides of the lung recruitment controversy...
  12. ncbi request reprint Ventilatory adjuncts
    Robert M Kacmarek
    Department of Respiratory Care Services, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts 02114, USA
    Respir Care 47:319-30; discussion 330-3. 2002
    ..No randomized trials of tracheal gas insufflation have been performed. Of major concern with tracheal gas insufflation is the lack of a commercial product...
  13. ncbi request reprint Should noninvasive ventilation be used with the do-not-intubate patient?
    Robert M Kacmarek
    Respiratory Care Services, Massachusetts General Hospital, Boston, MA 02114, USA
    Respir Care 54:223-9; discussion 229-31. 2009
    ....
  14. ncbi request reprint Liquid ventilation
    Robert M Kacmarek
    Harvard Medical School, Respiratory Care Services, Massachusetts General Hospital, Boston, MA 02114, USA
    Respir Care Clin N Am 8:187-209. 2002
    ..Based on the failure of the two trials in adult ARDS patients, however, a long time may pass before another human PLV trial is undertaken...
  15. ncbi request reprint Creating a vision for respiratory care in 2015 and beyond
    Robert M Kacmarek
    Respiratory Care Services, Massachusetts General Hospital, Boston, MA 02114, USA
    Respir Care 54:375-89. 2009
    ..We present the initial findings of that task force...
  16. ncbi request reprint Lung recruitment maneuvers during acute respiratory distress syndrome: is it useful?
    R M Kacmarek
    Department of Anesthesiology, Harvard Medical School, Boston, MA, USA
    Minerva Anestesiol 77:85-9. 2011
    ..Specifically, the ability of RM to open the lung, the safety of RM, and their affect on outcome are addressed. Finally, a specific approach to performing RM with the use of a decremental PEEP trial is outlined...
  17. ncbi request reprint Delivery systems for long-term oxygen therapy
    R M Kacmarek
    Respiratory Care Services, Massachusetts General Hospital, Boston 02114 2696, USA
    Respir Care 45:84-92; discussion 92-4. 2000
    ..As a result of the anticipated large number of patients worldwide expected to require home oxygen therapy, ongoing improvement in this technology will be evident in the next few years...
  18. doi request reprint The mechanical ventilator: past, present, and future
    Robert M Kacmarek
    Respiratory Care Services, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 01460, USA
    Respir Care 56:1170-80. 2011
    ..The key term that will be used to identify these future ventilators will be smart!..
  19. ncbi request reprint The relationship between gas delivery patterns and the lower inflection point of the pressure-volume curve during partial liquid ventilation
    G Ferreyra
    Department of Anaesthesia Respiratory Care, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Chest 117:191-8. 2000
    ..gif" BORDER="0">), and volume vs time waveforms during partial liquid ventilation (PLV)...
  20. ncbi request reprint Optimal mean airway pressure during high-frequency oscillation: predicted by the pressure-volume curve
    S Goddon
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Anesthesiology 94:862-9. 2001
    ..77, P < 0.05). CONCLUSION: In this model of acute respiratory distress syndrome, optimal Paw during HFO is equal to P(CL) + 6, which correlates with the PMC...
  21. ncbi request reprint Strategies to optimize alveolar recruitment
    R M Kacmarek
    Department of Anesthesia, Harvard Medical School, Respiratory Care, Massachusetts General Hospital, Boston, Massachusetts, USA
    Curr Opin Crit Care 7:15-20. 2001
    ....
  22. ncbi request reprint Heliox delivery with noninvasive positive pressure ventilation: a laboratory study
    S Chatmongkolchart
    Department of Respiratory Care, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Respir Care 46:248-54. 2001
    ..With heliox there was a potential for ventilator malfunction in some conditions. The clinical implications of these findings remain to be determined...
  23. ncbi request reprint The response of flow-triggered infant ventilators
    M Nishimura
    Respiratory Care Department Laboratory, Massachusetts General Hospital, Boston 02114, USA
    Am J Respir Crit Care Med 152:1901-9. 1995
    ..04 +/- 0.02 cm H2O; trigger work 114.48 +/- 0.88 g.ml). PTV may not be appropriate under conditions of increased ventilatory drive and small endotracheal tube size in infants...
  24. ncbi request reprint Open-lung protective ventilation with pressure control ventilation, high-frequency oscillation, and intratracheal pulmonary ventilation results in similar gas exchange, hemodynamics, and lung mechanics
    Khaled A Sedeek
    Department of Anesthesia Respiratory Care, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Anesthesiology 99:1102-11. 2003
    ....
  25. ncbi request reprint The effect of heliox on nebulizer function using a beta-agonist bronchodilator
    D R Hess
    Department of Respiratory Care, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Chest 115:184-9. 1999
    ..To evaluate nebulizer performance when heliox was used to power the nebulizer...
  26. ncbi request reprint Repetitive high-pressure recruitment maneuvers required to maximally recruit lung in a sheep model of acute respiratory distress syndrome
    Y Fujino
    Respiratory Care Department Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Crit Care Med 29:1579-86. 2001
    ..Multiple recruitment maneuvers in some animals were required for maximum effect...
  27. ncbi request reprint In vitro evaluation of aerosol bronchodilator delivery during mechanical ventilation: pressure-control vs. volume control ventilation
    Dean R Hess
    Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Intensive Care Med 29:1145-50. 2003
    ..To determine the effect of inspiratory time and inspiratory flow pattern on albuterol delivery by aerosol during mechanical ventilation...
  28. doi request reprint Adaptive support ventilation: an appropriate mechanical ventilation strategy for acute respiratory distress syndrome?
    Demet Sulemanji
    Department of Anesthesiology and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Anesthesiology 111:863-70. 2009
    ..Adaptive support ventilation (ASV) allows the clinician to set a maximum plateau pressure (PP) and automatically adjusts tidal volume to keep PP below the set maximum...
  29. ncbi request reprint Set positive end-expiratory pressure during protective ventilation affects lung injury
    Muneyuki Takeuchi
    Department of Anesthesia Respiratory Care, Massachusetts General Hospital, The Center for Blood Research, Boston 02114, USA
    Anesthesiology 97:682-92. 2002
    ..The most appropriate method of determining positive end-expiratory pressure (PEEP) level during a lung protective ventilatory strategy has not been established...
  30. pmc Low concentrations of nitric oxide increase oxygen affinity of sickle erythrocytes in vitro and in vivo
    C A Head
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, Massachusetts 02115, USA
    J Clin Invest 100:1193-8. 1997
    ..These results suggest that low concentrations of NO gas may offer an attractive new therapeutic model for the treatment of SCD...
  31. doi request reprint Adult ICU ventilators to provide neonatal ventilation: a lung simulator study
    Andrew D Marchese
    Respiratory Care Massachusetts General Hospital, Boston, MA 02114, USA
    Intensive Care Med 35:631-8. 2009
    ..Traditionally, specific ventilators have been manufactured to only provide neonatal mechanical ventilation. However, many of the current generation of ICU ventilators also include a neonatal mode...
  32. pmc The impact of endotracheal suctioning on gas exchange and hemodynamics during lung-protective ventilation in acute respiratory distress syndrome
    Maria Paula Caramez
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, and with Harvard Medical School, Boston Massachusetts 02114, USA
    Respir Care 51:497-502. 2006
    ....
  33. ncbi request reprint Combination therapy
    R M Kacmarek
    Department of Anesthesia, Harvard Medical School, Boston, Massachusetts, USA
    Respir Care Clin N Am 7:663-81. 2001
    ..Clearly, more laboratory and clinical studies examining the combined use of these therapies are needed, as is identification of the specific patient populations where these combined therapies may be most effective...
  34. pmc Gas exchange impairment induced by open suctioning in acute respiratory distress syndrome: impact of permissive hypercapnia
    Maria Paula Caramez
    Department of Anesthesia and Critical Care, and Respiratory Care, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Crit Care Med 36:560-4. 2008
    ..To determine whether hypercarbia occurs following the use of open suctioning in lung lavage injured sheep and whether the baseline PaCO2 and duration of suctioning affect gas exchange...
  35. ncbi request reprint Continuous positive airway pressure in new-generation mechanical ventilators: a lung model study
    Muneyuki Takeuchi
    Department of Anesthesia and Respiatory Care, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Anesthesiology 96:162-72. 2002
    ..However, the ability of these ventilators to provide continuous positive airway pressure without imposing or performing work has never been evaluated...
  36. ncbi request reprint The impact of closed endotracheal suctioning systems on mechanical ventilator performance
    Ashraf El Masry
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston 02114, USA
    Respir Care 50:345-53. 2005
    ..Closed endotracheal suctioning during mechanical ventilation is increasingly used, but its impact on ventilator function has not been fully studied...
  37. ncbi request reprint Position of exhalation port and mask design affect CO2 rebreathing during noninvasive positive pressure ventilation
    Guilherme P P Schettino
    Department of Anesthesia and Critical Care and Respiratory Care, Massachusetts General Hospital, Harvard Medical School, Boston, 02214, USA
    Crit Care Med 31:2178-82. 2003
    ..This study was conducted to evaluate the effect of exhalation port location and mask design on CO2 rebreathing during noninvasive positive pressure ventilation...
  38. ncbi request reprint Peak pressure during volume history and pressure-volume curve measurement affects analysis
    M Takeuchi
    Department of Anesthesia/Respiratory Care, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Am J Respir Crit Care Med 164:1225-30. 2001
    ..Pflex, Cstart, Cend, and Ctop were not affected by the PIP. However, UIP, PMC, Cinf, and Cdef increased as the PIP increased. Volume history and the PIP during P-V curve measurements affect both the inflation and deflation P-V curves...
  39. ncbi request reprint Evaluation of inspiratory rise time and inspiration termination criteria in new-generation mechanical ventilators: a lung model study
    S Chatmongkolchart
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Respir Care 46:666-77. 2001
    ..Inspiration termination criteria adjustment markedly affects transition to exhalation in the Puritan Bennett 840...
  40. ncbi request reprint Comparison of the effects of nitric oxide, nitroprusside, and nifedipine on hemodynamics and right ventricular contractility in patients with chronic pulmonary hypertension
    B A Cockrill
    Pulmonary and Critical Care Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Chest 119:128-36. 2001
    ..The effects of inhaled nitric oxide (NO) on hemodynamics and right ventricular (RV) contractility were compared with those of nitroprusside and nifedipine in 14 patients with severe chronic pulmonary hypertension...
  41. doi request reprint The principle of upper airway unidirectional flow facilitates breathing in humans
    Yandong Jiang
    Dept of Respiratory Care, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Appl Physiol (1985) 105:854-8. 2008
    ..We suggest this may be the reason that such a breathing pattern is preferred during respiratory distress...
  42. ncbi request reprint Factors affecting oxygen delivery with bi-level positive airway pressure
    Andrew R Schwartz
    Respiratory Care, Ellison 401, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Respir Care 49:270-5. 2004
    ..We conducted this study to test the hypothesis that delivered oxygen concentration using this configuration is affected by the choice of leak port, oxygen injection site, and ventilator settings...
  43. ncbi request reprint Peak volume history and peak pressure-volume curve pressures independently affect the shape of the pressure-volume curve of the respiratory system
    Tomoyo Nishida
    Department of Anesthesia Respiratory Care, Massachusetts General Hospital, Boston, MA 02114, USA
    Crit Care Med 32:1358-64. 2004
    ..To determine the specific effect of peak volume history pressure on the inflation limb of the pressure-volume curve and peak pressure-volume curve pressure on the deflation limb of the pressure-volume curve...
  44. ncbi request reprint Noninvasive positive-pressure ventilation in acute respiratory failure outside clinical trials: experience at the Massachusetts General Hospital
    Guilherme Schettino
    Harvard Medical School and Massachusetts General Hospital, Boston, MA, USA
    Crit Care Med 36:441-7. 2008
    ..However, few data are available on the use of NPPV as routine standard medical care for patients with respiratory failure outside of controlled trials...
  45. ncbi request reprint Noninvasive positive pressure ventilation reverses acute respiratory failure in select "do-not-intubate" patients
    Guilherme Schettino
    Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Crit Care Med 33:1976-82. 2005
    ..To determine the outcome from the use of noninvasive positive pressure ventilation (NPPV) in "do-not-intubate" (DNI) patients in acute respiratory failure...
  46. doi request reprint Nasal ventilation is more effective than combined oral-nasal ventilation during induction of general anesthesia in adult subjects
    Yafen Liang
    Department of Anesthesia and Critical Care, MassachusettsGeneral Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Anesthesiology 108:998-1003. 2008
    ..They tested this hypothesis by comparing the volume of carbon dioxide removed per breath with nasal versus combined oral-nasal mask ventilation in nonparalyzed, apneic, adult subjects during induction of general anesthesia...
  47. doi request reprint Trigger performance of mid-level ICU mechanical ventilators during assisted ventilation: a bench study
    Juliana C Ferreira
    Departments of Respiratory Care and Anesthesia and Critical Care, Massachusetts General Hospital, Boston, MA 02114, USA
    Intensive Care Med 34:1669-75. 2008
    ..To compare the triggering performance of mid-level ICU mechanical ventilators with a standard ICU mechanical ventilator...
  48. ncbi request reprint Competencies needed by graduate respiratory therapists in 2015 and beyond
    Thomas A Barnes
    Department of Health Sciences, Northeastern University, 360 Huntington Avenue, Boston, MA 02115 5000, USA
    Respir Care 55:601-16. 2010
    ..Future specialty practice areas for experienced RTs are identified without defining specific competencies. We present the findings of the task force on the competencies needed by graduate RTs upon entry into practice in 2015...
  49. doi request reprint A comparison of methods to identify open-lung PEEP
    Maria Paula Caramez
    Department of Anesthesia and Critical Care, and Respiratory Care, Massachusetts General Hospital, Boston, MA, USA
    Intensive Care Med 35:740-7. 2009
    ..Many methods exist in the literature for identifying PEEP to set in ARDS patients following a lung recruitment maneuver (RM). We compared ten published parameters for setting PEEP following a RM...
  50. ncbi request reprint Performance comparison of 15 transport ventilators
    Daniel W Chipman
    Department of Respiratory Care, Massachusetts General Hospital, Boston MA 02114, USA
    Respir Care 52:740-51. 2007
    ..Numerous mechanical ventilators are designed and marketed for use in patient transport. The complexity of these ventilators differs considerably, but very few data exist to compare their operational capabilities...
  51. pmc High-frequency oscillatory ventilation: what large-animal studies have taught us!
    Robert M Kacmarek
    Department of Anesthesiology, Harvard Medical School, Boston, MA, USA
    Crit Care Med 33:S148-54. 2005
    ..Specifically, large animal data have been useful in assessing adult application because large animals present many of the same concerns and challenges as adults...
  52. ncbi request reprint Cellular phone interference with the operation of mechanical ventilators
    Cheryl I Shaw
    Department of Biomedical Engineering, Massachusetts General Hospital, Boston, MA, USA
    Crit Care Med 32:928-31. 2004
    ..To determine whether a cellular phone would interfere with the operation of mechanical ventilators...
  53. ncbi request reprint Wheeze detection in the pediatric intensive care unit: comparison among physician, nurses, respiratory therapists, and a computerized respiratory sound monitor
    Parthak Prodhan
    Division of Pediatric Critical Care Medicine, MassGeneral Hospital for Children, Harvard Medical School, Boston, Massachusetts 02114, USA
    Respir Care 53:1304-9. 2008
    ..To correlate wheeze detection in the pediatric intensive care unit among staff members (a physician, nurses, and respiratory therapists [RTs]) and digital recordings from a computerized respiratory sound monitor (PulmoTrack)...
  54. ncbi request reprint Screening of ARDS patients using standardized ventilator settings: influence on enrollment in a clinical trial
    Niall D Ferguson
    Division of Respirology, Department of Medicine, and the Interdepartmental Division of Critical Care Medicine, University Health Network and Mount Sinai Hospital, University of Toronto, Toronto, Canada
    Intensive Care Med 30:1111-6. 2004
    ....
  55. pmc Pro/con clinical debate: is high-frequency oscillatory ventilation useful in the management of adult patients with respiratory failure?
    Jeffrey M Singh
    Department of Medicine, Mount Sinai Hospital, Toronto, Canada
    Crit Care 6:183-5. 2002
    ....
  56. ncbi request reprint Lung protection: the cost in some is increased work of breathing. Is it too high?
    Robert M Kacmarek
    Respir Care 50:1614-6. 2005
  57. ncbi request reprint Reversibility of lung collapse and hypoxemia in early acute respiratory distress syndrome
    Joao B Borges
    Respiratory Intensive Care Unit, Pulmonary Department, and General Intensive Care Unit, Emergency Clinics Division, Hospital das Clinicas, University of Sao Paulo, Sao Paulo, Brazil
    Am J Respir Crit Care Med 174:268-78. 2006
    ..The hypothesis that lung collapse is detrimental during the acute respiratory distress syndrome is still debatable. One of the difficulties is the lack of an efficient maneuver to minimize it...
  58. ncbi request reprint A decremental PEEP trial identifies the PEEP level that maintains oxygenation after lung recruitment
    Karim Girgis
    Surgical Intensive Care Unit, New Kasr El Aini Teaching Hospital and Cairo University, Cairo, Egypt
    Respir Care 51:1132-9. 2006
    ..To assess the ability of a decremental trial of positive end-expiratory pressure (PEEP) to identify an optimal PEEP level that maintains oxygenation after a lung-recruitment maneuver...
  59. ncbi request reprint Is high frequency oscillation the best lung protective ventilatory approach for ARDS?
    Robert M Kacmarek
    Intensive Care Med 29:1629-31. 2003
  60. ncbi request reprint Successful recruitment
    G A Richards
    Crit Care Med 30:2169; author reply 2169-70. 2002
  61. ncbi request reprint In vitro evaluation of aerosol bronchodilator delivery during noninvasive positive pressure ventilation: effect of ventilator settings and nebulizer position
    Sunisa Chatmongkolchart
    Department of Anesthesiology, Faculty of Medicine, Prince of Songkla University, Thailand
    Crit Care Med 30:2515-9. 2002
    ..However, there have been no reports of factors affecting aerosol delivery during NPPV. Our objective was to determine the effect of ventilator settings and nebulizer position on albuterol delivery during NPPV...
  62. ncbi request reprint Why are physicians so skeptical about positive randomized controlled clinical trials in critical care medicine?
    Jesus Villar
    Research Institute, Hospital Universitario N S de Candelaria, Carretera del Rosario s n, Canary Islands, 38010, Santa Cruz de Tenerife, Spain
    Intensive Care Med 31:196-204. 2005
  63. ncbi request reprint Determinants of tidal volume during high-frequency oscillation
    Khaled A Sedeek
    Department of Anesthesia Respiratory Care, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Crit Care Med 31:227-31. 2003
    ..However, limited data are available on the effect of pressure amplitude and rate (Hz) on tidal volumes delivered during high-frequency oscillation in adults...
  64. ncbi request reprint NPPV in acute respiratory failure: is it time to reconsider where it may be applied?
    Robert M Kacmarek
    Respir Care 51:1226-7. 2006
  65. ncbi request reprint Combining high-frequency oscillatory ventilation and recruitment maneuvers in adults with early acute respiratory distress syndrome: the Treatment with Oscillation and an Open Lung Strategy (TOOLS) Trial pilot study
    Niall D Ferguson
    Department of Medicine, Division of Respirology, and the Interdepartmental Division of Critical Care Medicine, University Health Network and Mount Sinai Hospital, University of Toronto, Toronto, Canada
    Crit Care Med 33:479-86. 2005
    ..To determine the safety, feasibility, and lung-recruitment efficacy of an explicit ventilation protocol combining high-frequency oscillatory ventilation and recruitment maneuvers...
  66. pmc Paradoxical responses to positive end-expiratory pressure in patients with airway obstruction during controlled ventilation
    Maria Paula Caramez
    Respiratory and Emergency Intensive Care Unit, Emergency Department, Hospital das Clinicas, University of Sao Paulo Medical School, Brazil
    Crit Care Med 33:1519-28. 2005
    ..The controversial occurrence of a paradoxic lung deflation promoted by PEEP was scrutinized...
  67. ncbi request reprint Respiratory controversies in the critical care setting. Should tidal volume be 6 mL/kg predicted body weight in virtually all patients with acute respiratory failure?
    Kenneth P Steinberg
    Division of Pulmonary and Critical Care Medicine, Harborview Medical Center, 325 Ninth Avenue, Box 359762, Seattle, WA 98104, USA
    Respir Care 52:556-64; discussion 565-7. 2007
    ..Consensus at this time is not possible, and this paper presents the arguments on both sides of the controversy...
  68. ncbi request reprint A high positive end-expiratory pressure, low tidal volume ventilatory strategy improves outcome in persistent acute respiratory distress syndrome: a randomized, controlled trial
    Jesus Villar
    Canarian Institute for Biomedical Research, Tomas Morales 6 1, 35003 Las Palmas de Gran Canaria, Canary Islands, Spain
    Crit Care Med 34:1311-8. 2006
    ....
  69. ncbi request reprint An early PEEP/FIO2 trial identifies different degrees of lung injury in patients with acute respiratory distress syndrome
    Jesus Villar
    Multidisciplinary Organ Dysfunction Evaluation Research Network, Hospital Universitario Dr Negrin, Las Palmas de Gran Canaria, Canary Islands, Spain
    Am J Respir Crit Care Med 176:795-804. 2007
    ....
  70. ncbi request reprint A protocol for high-frequency oscillatory ventilation in adults: results from a roundtable discussion
    Henry E Fessler
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, USA
    Crit Care Med 35:1649-54. 2007
    ..We provide guidelines for HFO in adults with acute respiratory distress syndrome that should optimize the lung-protective characteristics of this ventilation mode...