Research Topics
| Hadine JoffeSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
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Publications
Treatment of depression and menopause-related symptoms with the serotonin-norepinephrine reuptake inhibitor duloxetineHadine Joffe
Perinatal and Reproductive Psychiatry Program, Department of Psychiatry, Massachusetts General Hospital, Boston, Mass 02114, USA
J Clin Psychiatry 68:943-50. 2007..Treatment strategies that target all of these symptoms together have not been investigated to date...
Relapse of vasomotor symptoms after discontinuation of the selective serotonin reuptake inhibitor escitalopram: results from the menopause strategies: finding lasting answers for symptoms and health research networkHadine Joffe
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Menopause 20:261-8. 2013..We hypothesized that relapse of VMS to baseline levels after SSRI cessation would be common and predicted by menopausal and psychological characteristics...- Metabolic activity in the insular cortex and hypothalamus predicts hot flashes: an FDG-PET studyHadine Joffe
Center for Women s Mental Health, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston Massachusetts 02114, USA
J Clin Endocrinol Metab 97:3207-15. 2012..Previous studies have implicated the insula during the perception of hot flashes and the hypothalamus in thermoregulatory dysfunction... 
Lifetime history of depression and anxiety disorders as a predictor of quality of life in midlife women in the absence of current illness episodesHadine Joffe
Department of Psychiatry, Center for Women s Mental Health, Massachusetts General Hospital, Harvard Medical School, Simches Research Bldg, 185 Cambridge St, Ste 2000, Boston, MA 02114, USA
Arch Gen Psychiatry 69:484-92. 2012....- Longitudinal follow-up of reproductive and metabolic features of valproate-associated polycystic ovarian syndrome features: A preliminary reportHadine Joffe
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Biol Psychiatry 60:1378-81. 2006..5% of 86 women. We now determine whether polycystic ovarian syndrome (PCOS) features reverse on valproate discontinutation... - Reproductive biology and psychotropic treatments in premenopausal women with bipolar disorderHadine Joffe
Perinatal and Reproductive Psychiatry Clinical Research Program, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
J Clin Psychiatry 68:10-5. 2007.... - Treatment of premenstrual worsening of depression with adjunctive oral contraceptive pills: a preliminary reportHadine Joffe
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
J Clin Psychiatry 68:1954-62. 2007..Oral contraceptive pills (OCPs) stabilize reproductive hormones and treat premenstrual dysphoric disorder. Management of depression that breaks through premenstrually has not been studied... - Menstrual cycle dysfunction associated with neurologic and psychiatric disorders: their treatment in adolescentsHadine Joffe
Perinatal and Reproductive Psychiatry, Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA
Ann N Y Acad Sci 1135:219-29. 2008..Use of these agents should be considered and weighed against the risk of using alternative agents, which have their own side effects, or not treating these serious neurologic and psychiatric disorders... - Depression is associated with worse objectively and subjectively measured sleep, but not more frequent awakenings, in women with vasomotor symptomsHadine Joffe
Perinatal and Reproductive Psychiatry Program, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Menopause 16:671-9. 2009..We aimed to determine if objectively measured sleep and perceived sleep quality are worse in depressed women with VMS than in nondepressed women with VMS... - Eszopiclone improves insomnia and depressive and anxious symptoms in perimenopausal and postmenopausal women with hot flashes: a randomized, double-blinded, placebo-controlled crossover trialHadine Joffe
Perinatal and Reproductive Psychiatry Clinical Research Program, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Am J Obstet Gynecol 202:171.e1-171.e11. 2010..Menopause-associated insomnia is commonly associated with other symptoms (hot flashes, depression, anxiety). Given frequent symptom cooccurrence, therapies targeting sleep may provide an important approach to treatment during midlife... - Augmentation of venlafaxine and selective serotonin reuptake inhibitors with zolpidem improves sleep and quality of life in breast cancer patients with hot flashes: a randomized, double-blind, placebo-controlled trialHadine Joffe
Perinatal and Reproductive Psychiatry Program, Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
Menopause 17:908-16. 2010..Alternative strategies are needed. We hypothesized that augmentation of SSRI/SNRI therapy with hypnotic agents would optimize hot flash therapy by improving sleep and quality of life... - Evaluation and management of sleep disturbance during the menopause transitionHadine Joffe
Center for Women s Mental Health, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
Semin Reprod Med 28:404-21. 2010..Sleep disorders in midlife women should be treated because substantial improvements in quality of life and health outcomes are achievable... - Increased estradiol and improved sleep, but not hot flashes, predict enhanced mood during the menopausal transitionHadine Joffe
Center for Women s Mental Health, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
J Clin Endocrinol Metab 96:E1044-54. 2011..Estrogen therapy (ET) and the hypnotic agent zolpidem were selected as interventions in a three-arm, double-blind, placebo-controlled trial to distinguish the effects of estradiol, sleep, and hot flashes on depression... - Menstrual dysfunction prior to onset of psychiatric illness is reported more commonly by women with bipolar disorder than by women with unipolar depression and healthy controlsHadine Joffe
Perinatal and Reproductive Psychiatry Clinical Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
J Clin Psychiatry 67:297-304. 2006..However, it is not always clear whether such abnormalities, reflecting disruption of the hypothalamic-pituitary-gonadal (HPG) axis, are caused by psychotropic treatments or associated with the disorder per se... - Assessment and treatment of hot flushes and menopausal mood disturbanceHadine Joffe
Department of Psychiatry, Perinatal and Reproductive Psychiatry Clinical Research Program, Massachusetts General Hospital, Harvard Medical School, 15 Parkman Street, WACC, Boston, MA 02114, USA
Psychiatr Clin North Am 26:563-80. 2003..As further evidence of the benefits of psychoactive medications for menopausal symptoms is established, the choice between using hormonal and nonhormonal therapies for management of menopausal symptoms will continue to evolve... - A putative relationship between valproic acid and polycystic ovarian syndrome: implications for treatment of women with seizure and bipolar disordersHadine Joffe
Department of Psychiatry, Massachusetts General Hospital, 15 Parkman Street, WACC 815, Boston, MA 02114, USA
Harv Rev Psychiatry 11:99-108. 2003 - Impact of oral contraceptive pill use on premenstrual mood: predictors of improvement and deteriorationHadine Joffe
Perinatal and Reproductive Psychiatry Clinical Research Program, Massachusetts General Hospital, 15 Parkman Street, WACC, Boston, MA 02114, USA
Am J Obstet Gynecol 189:1523-30. 2003..The purpose of this study was to estimate risk factors for the deterioration and improvement of premenstrual mood disturbance with oral contraceptive pill use... - Valproate is associated with new-onset oligoamenorrhea with hyperandrogenism in women with bipolar disorderHadine Joffe
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Biol Psychiatry 59:1078-86. 2006..The development of PCOS features after initiation of valproate was therefore examined in women with bipolar disorder using a standardized definition of PCOS... - Vasomotor symptoms are associated with depression in perimenopausal women seeking primary careHadine Joffe
Perinatal and Reproductive Psychiatry Program, Reproductive Endocrine Unit, and Medical Service, Massachusetts General Hospital, Boston, MA, USA
Menopause 9:392-8. 2002..To compare the relationship between vasomotor symptoms (hot flushes and night sweats) and depression in perimenopausal women with that in postmenopausal and older premenopausal women... - Estrogen therapy selectively enhances prefrontal cognitive processes: a randomized, double-blind, placebo-controlled study with functional magnetic resonance imaging in perimenopausal and recently postmenopausal womenHadine Joffe
Women s Center for Behavioral Endocrinology, McLean Hospital, Harvard Medical School, Boston, MA, USA
Menopause 13:411-22. 2006.... - Vasomotor symptoms and insulin resistance in the study of women's health across the nationRebecca C Thurston
Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, Pennsylvania 15213, USA
J Clin Endocrinol Metab 97:3487-94. 2012..OBJECTIVE AND MAIN OUTCOME MEASURES: We examined the associations between hot flashes/night sweats and glucose and insulin resistance over 8 yr, controlling for cardiovascular risk factors and reproductive hormones... - Vasomotor symptoms and lipid profiles in women transitioning through menopauseRebecca C Thurston
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Obstet Gynecol 119:753-61. 2012..To examine associations between vasomotor symptoms and lipids over 8 years, controlling for other cardiovascular risk factors, estradiol, and follicle-stimulating hormone... - Paroxetine versus placebo for women in midlife after hormone therapy discontinuationClaudio N Soares
Perinatal and Reproductive Psychiatry Program, Massachusetts General Hospital, Boston, USA
Am J Med 121:159-162.e1. 2008..This study examines the efficacy of paroxetine controlled-release versus placebo for the treatment of women with vasomotor symptoms after discontinuing hormone therapy... - Eszopiclone in patients with insomnia during perimenopause and early postmenopause: a randomized controlled trialClaudio N Soares
Department of Psychiatry and Behavioral Neurosciences, McMaster University, Hamilton, Ontario, Canada, and Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA
Obstet Gynecol 108:1402-10. 2006..To evaluate eszopiclone 3 mg for treatment of insomnia in perimenopausal and early postmenopausal women, as well as the impact of insomnia treatment on mood, menopause-related symptoms, and quality of life... - Gains in body fat and vasomotor symptom reporting over the menopausal transition: the study of women's health across the nationRebecca C Thurston
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
Am J Epidemiol 170:766-74. 2009..The relations between body fat changes and night sweats were not statistically significant. Body fat gains are associated with greater hot flash reporting during the menopausal transition... - Physical activity and risk of vasomotor symptoms in women with and without a history of depression: results from the Harvard Study of Moods and CyclesRebecca C Thurston
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Menopause 13:553-60. 2006..To examine whether physical activity was associated with decreased risk of vasomotor symptoms in a prospective study of women transitioning through menopause... - Longitudinal follow-up of bipolar disorder in women with premenstrual exacerbation: findings from STEP-BDRodrigo S Dias
Bipolar Clinic and Research Program, Massachusetts General Hospital, Boston, USA
Am J Psychiatry 168:386-94. 2011..The authors determined the course of illness and time to relapse of bipolar disorder in prospectively followed women with premenstrual exacerbation... - Diagnosis and management of mood disorders during the menopausal transitionLee S Cohen
Department of Perinatal and Reproductive Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Am J Med 118:93-7. 2005..The benefits and risks of using hormonal and nonhormonal strategies for the management of depression and other menopause-related somatic symptoms are critically reviewed... - Vasomotor symptoms and menopause: findings from the Study of Women's Health across the NationRebecca C Thurston
Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Obstet Gynecol Clin North Am 38:489-501. 2011..We have reviewed the literature on VMS, emphasizing findings that have emerged from SWAN and new areas of inquiry in the area of VMS... - Omega-3 fatty acids for major depressive disorder associated with the menopausal transition: a preliminary open trialMarlene P Freeman
Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Menopause 18:279-84. 2011..We sought to obtain preliminary data regarding the efficacy of omega-3 fatty acids for major depressive disorder associated with the menopausal transition. Secondary outcomes were assessed for vasomotor symptoms (or hot flashes)... - Gender differences in bipolar disorder: retrospective data from the first 500 STEP-BD participantsClaudia F Baldassano
Bipolar Disorders Program, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
Bipolar Disord 7:465-70. 2005..To examine gender differences in a large sample of patients with bipolar illness... - Effect of medroxyprogesterone on depressive symptoms in depressed and nondepressed perimenopausal and postmenopausal women after discontinuation of transdermal estradiol therapyMaria Pia Rogines-Velo
Center for Women s Mental Health, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Menopause 19:471-5. 2012.... - A reproductive subtype of depression: conceptualizing models and moving toward etiologyJennifer L Payne
Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
Harv Rev Psychiatry 17:72-86. 2009..This review will provide evidence supporting reproductive depression as a distinct clinical entity with specific treatment approaches and a unique biology that is separate from nonreproductive depression... - Menopause and moodClaudio N Soares
Center for Women's Mental Health, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Clin Obstet Gynecol 47:576-91. 2004 - Incidence of hospitalization for postpartum psychotic and bipolar episodes in women with and without prior prepregnancy or prenatal psychiatric hospitalizationsBernard L Harlow
Obstetrics and Gynecology Epidemiology Center, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Arch Gen Psychiatry 64:42-8. 2007..Postpartum psychosis occurs in 1 to 2 cases per 1000 live births. Most studies have not distinguished postpartum psychosis from bipolar disorder or the proportion of the incidence attributable to prepregnancy psychiatric morbidity... - Psychosocial features associated with lifetime comorbidity of major depression and anxiety disorders among a community sample of mid-life women: the SWAN mental health studyJill M Cyranowski
Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Depress Anxiety 29:1050-7. 2012..This report evaluates clinical, psychological, social, and stress-related characteristics associated with a lifetime history of MDD and anxiety... - Mood symptoms after natural menopause and hysterectomy with and without bilateral oophorectomy among women in midlifeCarolyn J Gibson
Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15213, USA
Obstet Gynecol 119:935-41. 2012..To examine whether mood symptoms increased more for women in the years after hysterectomy with or without bilateral oophorectomy relative to natural menopause... - Sociodemographic predictors of antenatal and postpartum depressive symptoms among women in a medical group practiceJanet W Rich-Edwards
Department of Ambulatory Care and Prevention, Harvard Pilgrim Health Care, Boston, MA 02215, USA
J Epidemiol Community Health 60:221-7. 2006..This study investigated whether race/ethnicity, age, finances, and partnership status were associated with antenatal and postpartum depressive symptoms... - Use of antidepressants during perimenopauseDeborah R Kim
Psychosomatic Medicine, Department of Psychiatry, Hospital of the University of Pennsylvania, 3535 Market Street, 2nd Floor Philadelphia, PA 19104, USA
Womens Health (Lond Engl) 2:627-37. 2006.... - Relation of daily urinary hormone patterns to vasomotor symptoms in a racially/ethnically diverse sample of midlife women: study of women's health across the nationEllen B Gold
Division of Epidemiology, Department of Public Health Sciences, School of Medicine, University of California, Davis, CA 95616, USA
Reprod Sci 14:786-97. 2007.... - Escitalopram versus ethinyl estradiol and norethindrone acetate for symptomatic peri- and postmenopausal women: impact on depression, vasomotor symptoms, sleep, and quality of lifeClaudio N Soares
Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
Menopause 13:780-6. 2006..To examine the efficacy and tolerability of escitalopram (ESCIT) compared to estrogen and progestogen therapy (EPT) for the treatment of symptomatic peri- and postmenopausal women... - Efficacy of 17beta-estradiol on depression: is estrogen deficiency really necessary?Claudio N Soares
J Clin Psychiatry 63:451; author reply 451-2. 2002
Research Grants
- PHYSIOLOGY OF ESTROGEN'S MOOD EFFECT IN MENOPAUSAL WOMENHadine Joffe; Fiscal Year: 2007..Such training will lay the foundation for a career of clinical investigation into the physiology of perimenopausal depression and the impact of hot flushes on sleep, mood, and quality-of-life. ..
- Defining the Mechanisms of Menopause-Associated Sleep and Mood DisturbancesHadine Joffe; Fiscal Year: 2010..This work has important public health relevance because it will inform the development of rational therapeutic strategies and lead to novel treatment paradigms for menopause- associated depression. ..