J L Januzzi

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi N-terminal pro-B-type natriuretic peptide testing improves the management of patients with suspected acute heart failure: primary results of the Canadian prospective randomized multicenter IMPROVE-CHF study
    Gordon W Moe
    University of Toronto, St Michael s Hospital, Toronto, Ontario, Canada
    Circulation 115:3103-10. 2007
  2. doi Natriuretic peptides as biomarkers in heart failure
    James L Januzzi
    Cardiology Division, Massachusetts General Hospital, Boston, MA 02114, USA
    J Investig Med 61:950-5. 2013
  3. doi ST2 as a cardiovascular risk biomarker: from the bench to the bedside
    James L Januzzi
    Cardiology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, 32 Fruit Street, Yawkey 5984, Boston, MA 02114, USA
    J Cardiovasc Transl Res 6:493-500. 2013
  4. doi Interleukin receptor family member ST2 concentrations in patients following heart transplantation
    James L Januzzi
    Division of Cardiology, Massachusetts General Hospital, Boston, MA 02114, USA
    Biomarkers 18:250-6. 2013
  5. doi Are serial BNP measurements useful in heart failure management? Serial natriuretic peptide measurements are useful in heart failure management
    James L Januzzi
    Cardiology Division, Massachusetts General Hospital, 32 Fruit St, Yawkey 5984, Boston, MA, 02114, USA
    Circulation 127:500-7; discussion 508. 2013
  6. doi Troponin elevation in patients with heart failure: on behalf of the third Universal Definition of Myocardial Infarction Global Task Force: Heart Failure Section
    James L Januzzi
    Cardiology Division, Massachusetts General Hospital, Yawkey 5984, 32 Fruit Street, Boston, MA 02114, USA
    Eur Heart J 33:2265-71. 2012
  7. doi Natriuretic peptide testing for predicting adverse events following heart failure hospitalization
    James L Januzzi
    Cardiology Division, Massachusetts General Hospital, 32 Fruit St, Boston, MA 02114, USA
    Congest Heart Fail 18:S9-S13. 2012
  8. doi The role of natriuretic peptide testing in guiding chronic heart failure management: review of available data and recommendations for use
    James L Januzzi
    Division of Cardiology, Massachusetts General Hospital, Yawkey 5984, Boston, MA 02114, USA
    Arch Cardiovasc Dis 105:40-50. 2012
  9. ncbi Utility of amino-terminal pro-brain natriuretic peptide testing for prediction of 1-year mortality in patients with dyspnea treated in the emergency department
    James L Januzzi
    Department of Internal Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    Arch Intern Med 166:315-20. 2006
  10. pmc Natriuretic peptide testing for the evaluation of critically ill patients with shock in the intensive care unit: a prospective cohort study
    James L Januzzi
    Division of Cardiology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Crit Care 10:R37. 2006

Detail Information

Publications94

  1. ncbi N-terminal pro-B-type natriuretic peptide testing improves the management of patients with suspected acute heart failure: primary results of the Canadian prospective randomized multicenter IMPROVE-CHF study
    Gordon W Moe
    University of Toronto, St Michael s Hospital, Toronto, Ontario, Canada
    Circulation 115:3103-10. 2007
    ..However, most of the data were derived from countries with high healthcare resource use, and randomized evidence for utility of NT-proBNP was lacking...
  2. doi Natriuretic peptides as biomarkers in heart failure
    James L Januzzi
    Cardiology Division, Massachusetts General Hospital, Boston, MA 02114, USA
    J Investig Med 61:950-5. 2013
    ..An historical perspective on the NPs from bench to bedside translation will be discussed. ..
  3. doi ST2 as a cardiovascular risk biomarker: from the bench to the bedside
    James L Januzzi
    Cardiology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, 32 Fruit Street, Yawkey 5984, Boston, MA 02114, USA
    J Cardiovasc Transl Res 6:493-500. 2013
    ....
  4. doi Interleukin receptor family member ST2 concentrations in patients following heart transplantation
    James L Januzzi
    Division of Cardiology, Massachusetts General Hospital, Boston, MA 02114, USA
    Biomarkers 18:250-6. 2013
    ..To evaluate soluble (s) ST2 as a biomarker of rejection, allograft vasculopathy and mortality after orthotopic heart transplantation (OHT)...
  5. doi Are serial BNP measurements useful in heart failure management? Serial natriuretic peptide measurements are useful in heart failure management
    James L Januzzi
    Cardiology Division, Massachusetts General Hospital, 32 Fruit St, Yawkey 5984, Boston, MA, 02114, USA
    Circulation 127:500-7; discussion 508. 2013
    ..Denial of the benefits of NP monitoring potentially retards advances in the care of a high-risk population of patients that continues to grow in size and importance every day...
  6. doi Troponin elevation in patients with heart failure: on behalf of the third Universal Definition of Myocardial Infarction Global Task Force: Heart Failure Section
    James L Januzzi
    Cardiology Division, Massachusetts General Hospital, Yawkey 5984, 32 Fruit Street, Boston, MA 02114, USA
    Eur Heart J 33:2265-71. 2012
    ....
  7. doi Natriuretic peptide testing for predicting adverse events following heart failure hospitalization
    James L Januzzi
    Cardiology Division, Massachusetts General Hospital, 32 Fruit St, Boston, MA 02114, USA
    Congest Heart Fail 18:S9-S13. 2012
    ..Thus, changes in BNP or NT-proBNP following treatment should be considered an important part of the pre-discharge decision making for patients hospitalized with ADHF...
  8. doi The role of natriuretic peptide testing in guiding chronic heart failure management: review of available data and recommendations for use
    James L Januzzi
    Division of Cardiology, Massachusetts General Hospital, Yawkey 5984, Boston, MA 02114, USA
    Arch Cardiovasc Dis 105:40-50. 2012
    ....
  9. ncbi Utility of amino-terminal pro-brain natriuretic peptide testing for prediction of 1-year mortality in patients with dyspnea treated in the emergency department
    James L Januzzi
    Department of Internal Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    Arch Intern Med 166:315-20. 2006
    ..Amino-terminal pro-brain natriuretic peptide (NT-proBNP) is useful for diagnosis and triage of patients with dyspnea, but its role for predicting outcomes in such patients remains undefined...
  10. pmc Natriuretic peptide testing for the evaluation of critically ill patients with shock in the intensive care unit: a prospective cohort study
    James L Januzzi
    Division of Cardiology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Crit Care 10:R37. 2006
    ..Amino-terminal pro-brain natriuretic peptide (NT-proBNP) is useful in evaluating heart failure, but its role in evaluating patients with shock in the intensive care unit (ICU) is not clear...
  11. ncbi What is the role of biomarker measurement after cardiac surgery?
    J L Januzzi
    Cardiology Division and Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Minerva Anestesiol 77:334-41. 2011
    ..Indeed, both cTn and natriuretic peptides are unequivocally prognostic for delayed recovery, intensive care unit utilization, as well as short- and longer-term mortalities following cardiac surgery...
  12. doi Importance of biomarkers for long-term mortality prediction in acutely dyspneic patients
    James L Januzzi
    Cardiology Division, Massachusetts General Hospital, Boston, MA, USA
    Clin Chem 56:1814-21. 2010
    ..Although numerous biomarkers may be prognostically meaningful in patients with acute dyspnea, few comparative analyses have addressed possible associations between a wide range of candidate biomarkers and clinical variables...
  13. ncbi Analytical and clinical performance of the Ortho-Clinical Diagnostics VITROS amino-terminal pro-B type natriuretic peptide assay
    James L Januzzi
    Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Yawkey 5984, 55 Fruit St Boston, MA 02114, USA
    Clin Chim Acta 387:48-54. 2008
    ..Measurement of amino-terminal pro-B-type natriuretic peptide (NT-proBNP) is useful for evaluating patients with heart failure (HF)...
  14. doi Evolution of amino-terminal pro-B type natriuretic peptide testing in heart failure
    James L Januzzi
    Cardiology Division, Massachusetts General Hospital, 55 Fruit Street, Yawkey 5984, Boston, Massachusetts 02114, USA
    Drug News Perspect 22:267-73. 2009
    ..This review will focus on the use of NTproBNP in clinical medicine, with a discussion of the biologic significance of NT-proBNP, its proven present uses and potential future applications...
  15. doi Amino-terminal pro-B-type natriuretic peptide testing for the diagnosis or exclusion of heart failure in patients with acute symptoms
    James L Januzzi
    Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Am J Cardiol 101:29-38. 2008
    ..Therefore, the logical use of NT-proBNP for the evaluation of the patient with suspected acute HF is useful, cost-effective, and may reduce adverse outcomes compared with standard clinical evaluation without natriuretic peptide testing...
  16. ncbi Measurement of the interleukin family member ST2 in patients with acute dyspnea: results from the PRIDE (Pro-Brain Natriuretic Peptide Investigation of Dyspnea in the Emergency Department) study
    James L Januzzi
    Department of Medicine and Laboratory Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Am Coll Cardiol 50:607-13. 2007
    ..The aim of this study was to examine the value of measurement of the interleukin-1 receptor family member ST2 in patients with dyspnea...
  17. ncbi NT-proBNP testing for diagnosis and short-term prognosis in acute destabilized heart failure: an international pooled analysis of 1256 patients: the International Collaborative of NT-proBNP Study
    James L Januzzi
    Cardiology Division, Massachusetts General Hospital, Yawkey 5984, 55 Fruit Street, Boston, MA 02114, USA
    Eur Heart J 27:330-7. 2006
    ..We wished to establish broader standards for NT-proBNP testing in a study involving four sites in three continents...
  18. ncbi Peripheral arterial disease, acute coronary syndromes, and early invasive management: the TACTICS TIMI 18 trial
    James L Januzzi
    Cardiology Division, Massachusetts General Hospital, Jawkey 5984, 55 Fruit Street, Boston, MA 02114, USA
    Clin Cardiol 28:238-42. 2005
    ..The efficacy and safety of early invasive management for such patients remains unclear. Hypothesis: Early invasive management would be well tolerated and effective among patients with NSTE ACS and PAD...
  19. ncbi Effects of renal insufficiency on early invasive management in patients with acute coronary syndromes (The TACTICS-TIMI 18 Trial)
    James L Januzzi
    Cardiology Division, Massachusetts General Hospital, Boston, Masssachusetts 02114, USA
    Am J Cardiol 90:1246-9. 2002
  20. doi Use of amino-terminal pro-B-type natriuretic peptide to guide outpatient therapy of patients with chronic left ventricular systolic dysfunction
    James L Januzzi
    Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Am Coll Cardiol 58:1881-9. 2011
    ..The aim of this study was to evaluate whether chronic heart failure (HF) therapy guided by concentrations of amino-terminal pro-B-type natriuretic peptide (NT-proBNP) is superior to standard of care (SOC) management...
  21. ncbi Comparison of aortic dissection in patients with and without Marfan's syndrome (results from the International Registry of Aortic Dissection)
    James L Januzzi
    Thoracic Aorta Center and Cardiology Division, Massachusetts General Hospital, Boston, 02114, USA
    Am J Cardiol 94:400-2. 2004
    ..Our data support the importance of aneurysm surveillance and prophylactic surgical intervention for patients with Marfan's syndrome to potentially reduce the risk of mortality...
  22. ncbi The N-terminal Pro-BNP investigation of dyspnea in the emergency department (PRIDE) study
    James L Januzzi
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Am J Cardiol 95:948-54. 2005
    ..NT-proBNP measurement is a valuable addition to standard clinical assessment for the identification and exclusion of acute CHF in the emergency department setting...
  23. ncbi Predicting a late positive serum troponin in initially troponin-negative patients with non-ST-elevation acute coronary syndrome: clinical predictors and validated risk score results from the TIMI IIIB and GUSTO IIA studies
    James L Januzzi
    Cardiology Division, Massachusetts General Hospital, Boston, MA 02114, USA
    Am Heart J 151:360-6. 2006
    ..Troponin testing is useful for evaluating patients with non-ST-segment elevation acute coronary syndromes (NSTE ACS); however, a significant percentage of patients are troponin negative at presentation and develop late rise of the marker...
  24. ncbi A risk score system for predicting adverse outcomes and magnitude of benefit with glycoprotein IIb/IIIa inhibitor therapy in patients with unstable angina pectoris
    M S Sabatine
    Division of Cardiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Am J Cardiol 88:488-92. 2001
    ....
  25. ncbi Combined use of amino terminal-pro-brain natriuretic peptide levels and QRS duration to predict left ventricular systolic dysfunction in patients with dyspnea
    Rahul Sakhuja
    Cardiology Division, and Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Am J Cardiol 96:263-6. 2005
    ..This strategy can be used to predict depressed function and target more formal evaluation with echocardiography in patients with dyspnea...
  26. ncbi The effects of ejection fraction on N-terminal ProBNP and BNP levels in patients with acute CHF: analysis from the ProBNP Investigation of Dyspnea in the Emergency Department (PRIDE) study
    Michelle O'Donoghue
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Card Fail 11:S9-14. 2005
    ..Limited data exist regarding the impact of left ventricular ejection fraction (LVEF) on N-terminal pro-brain natriuretic peptide (NT-proBNP) and B-type natriuretic peptide (BNP) levels in patients with acute congestive heart failure (CHF)...
  27. pmc Plasma C-reactive protein levels are associated with improved outcome in ARDS
    Ednan K Bajwa
    Pulmonary and Critical Care Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Chest 136:471-80. 2009
    ..We sought to examine plasma levels of CRP in patients with ARDS and their relationship to outcome and measures of illness severity...
  28. ncbi Elevation in serum troponin I predicts the benefit of tirofiban
    J L Januzzi
    Cardiology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
    J Thromb Thrombolysis 11:211-5. 2001
    ..CONCLUSION: Irrespective of high-risk clinical factors, including ST segment depression, these data support the hypothesis that serum troponins identify those who benefit from aggressive antiplatelet therapy with tirofiban...
  29. ncbi Amino-terminal pro-brain natriuretic peptide for the diagnosis of acute heart failure in patients with previous obstructive airway disease
    Roderick H Tung
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Ann Emerg Med 48:66-74. 2006
    ..We evaluate results from amino-terminal pro-brain natriuretic peptide (NT-proBNP) testing with or without those of clinical judgment for the evaluation of dyspneic patients with previous chronic obstructive pulmonary disease or asthma...
  30. ncbi Cost-effectiveness of using N-terminal pro-brain natriuretic peptide to guide the diagnostic assessment and management of dyspneic patients in the emergency department
    Uwe Siebert
    Institute for Technology Assessment and Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Cardiol 98:800-5. 2006
    ....
  31. ncbi Amino-terminal pro-brain natriuretic peptide, brain natriuretic peptide, and troponin T for prediction of mortality in acute heart failure
    Rahul Sakhuja
    Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Clin Chem 53:412-20. 2007
    ..Combining testing for natriuretic peptides [amino-terminal pro-brain natriuretic peptide (NT-proBNP) and brain natriuretic peptide (BNP)] and cardiac troponin T (cTnT) may help predict mortality in patients with acute heart failure (HF)...
  32. ncbi Effect of body mass index on natriuretic peptide levels in patients with acute congestive heart failure: a ProBNP Investigation of Dyspnea in the Emergency Department (PRIDE) substudy
    Daniel G Krauser
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Mass 02114, USA
    Am Heart J 149:744-50. 2005
    ..Neither the mechanism of natriuretic peptide suppression in the obese patient nor whether obesity affects natriuretic peptide levels among patients with acute CHF is known...
  33. ncbi Combination of D-dimer and amino-terminal pro-B-type natriuretic Peptide testing for the evaluation of dyspneic patients with and without acute pulmonary embolism
    Stacy E F Melanson
    Department of Pathology, Division of Clinical Laboratories, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass, USA
    Arch Pathol Lab Med 130:1326-9. 2006
    ..However, clinicians frequently order unnecessary supplemental testing in patients with low concentrations of D-dimer. Elevations in natriuretic peptides have also been described in the setting of pulmonary embolism...
  34. ncbi Long-term survival in patients presenting with type B acute aortic dissection: insights from the International Registry of Acute Aortic Dissection
    Thomas T Tsai
    Department of Internal Medicine, Division of Cardiology, University of Michigan Medical Center, Ann Arbor, MI 48106 0384, USA
    Circulation 114:2226-31. 2006
    ..We used data from a contemporary registry of acute type B aortic dissection to better understand factors associated with adverse long-term survival...
  35. doi Independent and incremental prognostic value of multimarker testing in acute dyspnea: results from the ProBNP Investigation of Dyspnea in the Emergency Department (PRIDE) study
    Shafiq U Rehman
    Cardiology Division and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA
    Clin Chim Acta 392:41-5. 2008
    ..Acute dyspnea is common in the emergency department (ED) and is associated with mortality. Biomarkers may help stratify risk in this setting...
  36. ncbi Utility of B-type natriuretic peptide for the evaluation of intensive care unit shock
    Roderick H Tung
    Department of Medicine, Massachusetts General Hospital, Boston, MA
    Crit Care Med 32:1643-7. 2004
    ..However, among critically ill intensive care unit patients with shock, the utility of B-type natriuretic peptide to assess cardiac hemodynamics or prognosis has not been explored...
  37. ncbi Renal function, congestive heart failure, and amino-terminal pro-brain natriuretic peptide measurement: results from the ProBNP Investigation of Dyspnea in the Emergency Department (PRIDE) Study
    Saif Anwaruddin
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Am Coll Cardiol 47:91-7. 2006
    ..Even in the presence of renal insufficiency, NT-proBNP remained a valuable tool for the diagnosis of acute congestive heart failure and it provides important prognostic information...
  38. ncbi A clinical and biochemical score for mortality prediction in patients with acute dyspnoea: derivation, validation and incorporation into a bedside programme
    A L Baggish
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Heart 94:1032-7. 2008
    ..Risk stratification for patients with acute dyspnoea is a challenging task. No quantitative tool for mortality prediction among patients with acute dyspnoea is available...
  39. doi Association between C-reactive protein and generalized anxiety disorder in stable coronary heart disease patients
    Bettina Bankier
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Eur Heart J 29:2212-7. 2008
    ....
  40. ncbi Benefits and safety of tirofiban among acute coronary syndrome patients with mild to moderate renal insufficiency: results from the Platelet Receptor Inhibition in Ischemic Syndrome Management in Patients Limited by Unstable Signs and Symptoms (PRISM-PLUS
    James L Januzzi
    Cardiology Division, Massachusetts General Hospital, Boston, MA, USA
    Circulation 105:2361-6. 2002
    ..The role of glycoprotein IIb/IIIa receptor antagonists for the treatment of patients with acute coronary syndrome and renal insufficiency remains undefined...
  41. ncbi Hemoglobin and N-terminal pro-brain natriuretic peptide: Independent and synergistic predictors of mortality in patients with acute heart failure Results from the International Collaborative of NT-proBNP (ICON) Study
    Aaron L Baggish
    PRIDE Study Group, and Cardiology Division, Massachusetts General Hospital, Boston, MA, USA
    Clin Chim Acta 381:145-50. 2007
    ..Hemoglobin and amino-terminal pro-brain natriuretic peptide (NT-proBNP) are both independent predictors of mortality in patients with chronic HF. Their combined predictive power for mortality in the setting of acute HF is uncertain...
  42. ncbi Natriuretic peptide testing: a window into the diagnosis and prognosis of heart failure
    James L Januzzi
    Harvard Medical School, Massachusetts General Hospital, Boston 02114, USA
    Cleve Clin J Med 73:149-52, 155-7. 2006
    ..However, clinical judgment must always be part of the evaluation of BNP or NT-proBNP assay results...
  43. ncbi Interactions between age, outcome of acute coronary syndromes, and tirofiban therapy
    James L Januzzi
    Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts, USA
    Am J Cardiol 91:457-61. 2003
  44. doi Hyponatremia, natriuretic peptides, and outcomes in acutely decompensated heart failure: results from the International Collaborative of NT-proBNP Study
    Asim A Mohammed
    Cardiology Division and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA
    Circ Heart Fail 3:354-61. 2010
    ..Associations between hyponatremia and other prognostic variables in acutely decompensated heart failure, such as amino-terminal pro-B type natriuretic peptide remain unclear...
  45. doi Association between major depressive disorder and C-reactive protein levels in stable coronary heart disease patients
    Bettina Bankier
    Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA
    J Psychosom Res 66:189-94. 2009
    ....
  46. ncbi Neither race nor gender influences the usefulness of amino-terminal pro-brain natriuretic peptide testing in dyspneic subjects: a ProBNP Investigation of Dyspnea in the Emergency Department (PRIDE) substudy
    Daniel G Krauser
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Card Fail 12:452-7. 2006
    ..Little is known about the effect of race on NT-proBNP concentrations. Also, NT-proBNP levels may be higher in apparently well women, but the effect of gender on NT-proBNP concentrations in dyspneic patients is not known...
  47. doi Characteristics of the novel interleukin family biomarker ST2 in patients with acute heart failure
    Shafiq U Rehman
    Department of Medicine, Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts, USA
    J Am Coll Cardiol 52:1458-65. 2008
    ..The purpose of this study was to examine the patient-specific characteristics of the interleukin-1 receptor family member ST2 in patients with acute heart failure (HF)...
  48. pmc Amino-terminal pro-B-type natriuretic peptide and high-sensitivity C-reactive protein as predictors of sudden cardiac death among women
    Ethan C Korngold
    Cardiovascular Division, Massachusetts General Hospital, Boston, MA, USA
    Circulation 119:2868-76. 2009
    ..However, there are no data on SCD risk prediction for either of these markers in a population of women unselected on the basis of cardiovascular disease...
  49. doi The differential diagnosis of an elevated amino-terminal pro-B-type natriuretic peptide level
    Aaron L Baggish
    Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Am J Cardiol 101:43-8. 2008
    ..Future studies will be necessary to further understand the utility of NT-proBNP testing in states other than cardiovascular disease...
  50. doi Soluble ST2 plasma concentrations predict 1-year mortality in acutely dyspneic emergency department patients with pulmonary disease
    Abelardo Martinez-Rumayor
    Department of Medicine, Massachusetts General Hospital, Boston, MA, USA
    Am J Clin Pathol 130:578-84. 2008
    ..20 ng/mL or more diverged early and rose progressively in 1 year (P < .001). ST2 concentrations are frequently elevated in acute pulmonary diseases and are markedly prognostic for death by 1 year...
  51. doi N-terminal pro-B-type natriuretic peptide (NT-proBNP) concentrations in hemodialysis patients: prognostic value of baseline and follow-up measurements
    ORLANDO M GUTIERREZ
    Nephrology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Clin Chem 54:1339-48. 2008
    ..Previous studies focused on prevalent dialysis patients and examined single measurements of NT-proBNP in time...
  52. ncbi Multi-center validation of the Response Biomedical Corporation RAMP NT-proBNP assay with comparison to the Roche Diagnostics GmbH Elecsys proBNP assay
    Elizabeth Lee-Lewandrowski
    Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Clin Chim Acta 386:20-4. 2007
    ..Point-of-care (POC) assays may provide more timely results and potentially improve patient outcomes...
  53. doi Amino-terminal pro-B-type natriuretic peptide testing and prognosis in patients with acute dyspnea, including those with acute heart failure
    Aaron L Baggish
    Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Am J Cardiol 101:49-55. 2008
    ....
  54. ncbi Partial thrombosis of the false lumen in patients with acute type B aortic dissection
    Thomas T Tsai
    Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan Medical Center, Ann Arbor, MI 48109 5853, USA
    N Engl J Med 357:349-59. 2007
    ..Patency or thrombosis of the false lumen in type B acute aortic dissection has been found to predict outcomes. The prognostic implications of partial thrombosis of the false lumen have not yet been elucidated...
  55. ncbi A validated clinical and biochemical score for the diagnosis of acute heart failure: the ProBNP Investigation of Dyspnea in the Emergency Department (PRIDE) Acute Heart Failure Score
    Aaron L Baggish
    Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Am Heart J 151:48-54. 2006
    ..No method integrating amino-terminal pro-brain natriuretic peptide (NT-proBNP) testing with clinical assessment for the evaluation of patients with suspected acute heart failure (HF) has been described...
  56. ncbi Effect of atrial septal mobility on transcatheter closure of interatrial communications
    Nandita S Scott
    Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Echocardiography 20:711-4. 2003
    ..The technique may be limited by the inability to deploy the device and, thus, may be complicated by significant residual shunting. Mobile or redundant septal tissue has been implicated as a possible cause of unsuccessful closure...
  57. ncbi Optimizing glycoprotein IIb/IIIa receptor antagonist use for the non-ST-segment elevation acute coronary syndromes: risk stratification and therapeutic intervention
    James L Januzzi
    Cardiology Division, Massachusetts General Hospital, Boston, Mass, USA
    Am Heart J 146:764-74. 2003
    ..In addition, we will consider appropriate methods/venues for use of GP IIb/IIIa receptor antagonism, including its role in an "early invasive" catheterization strategy...
  58. doi The role of natriuretic peptides as biomarkers for guiding the management of chronic heart failure
    S R Motiwala
    Division of Cardiology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Clin Pharmacol Ther 93:57-67. 2013
    ..This review examines the biology of natriuretic peptides, discusses the rationale for their use in HF, and details the aggregate experience gained thus far in biomarker-guided care...
  59. ncbi Association of atrial fibrillation and amino-terminal pro-brain natriuretic peptide concentrations in dyspneic subjects with and without acute heart failure: results from the ProBNP Investigation of Dyspnea in the Emergency Department (PRIDE) study
    Angela Morello
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Am Heart J 153:90-7. 2007
    ..Atrial fibrillation (AF) may cause dyspnea in the absence of acute HF and may also affect plasma levels of NT-proBNP...
  60. doi Pre-existing major depression predicts in-hospital cardiac complications after acute myocardial infarction
    Jeff C Huffman
    Massachusetts General Hospital, 55 Fruit Street Warren 1220C, Boston, MA 02114, USA
    Psychosomatics 49:309-16. 2008
    ..Depression (MDD) and anxiety have been associated with negative long-term outcomes among patients with acute myocardial infarction (MI)...
  61. doi Inflammatory markers, amino-terminal pro-brain natriuretic peptide, and mortality risk in dyspneic patients
    Shafiq Rehman
    Cardiology Division and Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Clin Pathol 130:305-11. 2008
    ..Among dyspneic patients, CRP levels are significantly associated with mortality at 1 year and show additive value to natriuretic peptide testing for prognosis...
  62. ncbi N-terminal proBNP: a novel biomarker for the diagnosis, risk stratification and management of congestive heart failure
    Michelle O'Donoghue
    Cardiology Division, Department of Medicine, Massachusetts General Hospital, 55 Fruit Street, Yawkey 5800, Boston, MA 02114, USA
    Expert Rev Cardiovasc Ther 3:487-96. 2005
    ....
  63. ncbi The high prevalence of multiple psychiatric disorders in stable outpatients with coronary heart disease
    Bettina Bankier
    Behavioral Medicine Division of Preventive Cardiology, Department of Psychiatry, Massachusetts General Hospital, and Harvard Medical School, 50 Staniford Street, Suite 401, Boston, MA 02114, USA
    Psychosom Med 66:645-50. 2004
    ..To date, no systematic comprehensive psychiatric diagnostic evaluation has been performed in a consecutive sample of stable CHD outpatients...
  64. ncbi Postoperative troponin-T predicts prolonged intensive care unit length of stay following cardiac surgery
    Aaron L Baggish
    Department of Medicine, Massachusetts General Hospital, Boston, MA, USA
    Crit Care Med 32:1866-71. 2004
    ..To evaluate the use of postoperative cardiac troponin T (cTnT) for the prediction of prolonged intensive care unit length of stay following cardiac surgery...
  65. ncbi Tirofiban therapy for patients with acute coronary syndromes and prior coronary artery bypass grafting in the PRISM-PLUS trial
    Stephen J Servoss
    Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Am J Cardiol 93:843-7. 2004
    ..1% vs 48.6%, p = 0.057). Bleeding rates were similar in patients with and without prior CABG. Tirofiban was well tolerated and tended to decrease the considerable risk for ischemic ACS complications in patients with prior CABG...
  66. pmc Prognostic value of plasma N-terminal probrain natriuretic peptide levels in the acute respiratory distress syndrome
    Ednan K Bajwa
    Pulmonary and Critical Care Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Crit Care Med 36:2322-7. 2008
    ..We sought to determine whether N-terminal probrain natriuretic peptide (NT-proBNP) levels are elevated in acute respiratory distress syndrome and whether they can serve as a marker of prognosis in this setting...
  67. ncbi NT-proBNP levels, echocardiographic findings, and outcomes in breathless patients: results from the ProBNP Investigation of Dyspnoea in the Emergency Department (PRIDE) echocardiographic substudy
    Annabel A Chen
    Division of Cardiology, Cardiac Ultrasound Laboratory, and Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, 02114, USA
    Eur Heart J 27:839-45. 2006
    ..The objective of this study was to determine the integrative utility of measuring plasma NT-proBNP levels with echocardiography in the evaluation of dyspnoeic patients...
  68. ncbi Recognition and treatment of depression and anxiety in patients with acute myocardial infarction
    Jeff C Huffman
    Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA
    Am J Cardiol 98:319-24. 2006
    ..Recognition and treatment of anxiety is substantially better, up to 50% of patients who are found to be anxious by psychiatrists after acute myocardial infarction remain unrecognized...
  69. ncbi Erythropoietin in cardiovascular diseases: exploring new avenues
    Peter van der Meer
    Cardiology Division, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA
    Clin Sci (Lond) 114:289-91. 2008
    ..In the present issue of Clinical Science, Piuhola and co-workers provide an interesting study that may shed light on the effects of EPO (and possibly related compounds) in the context of acute MI...
  70. pmc Pathogenetic and prognostic significance of altered coagulation and fibrinolysis in acute lung injury/acute respiratory distress syndrome
    Lorraine B Ware
    Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    Crit Care Med 35:1821-8. 2007
    ..However, direct evidence for the contribution of abnormalities in coagulation and fibrinolysis proteins to outcomes in patients with acute lung injury/acute respiratory distress syndrome is lacking...
  71. ncbi Screening for major depression in post-myocardial infarction patients: operating characteristics of the Beck Depression Inventory-II
    Jeff C Huffman
    Harvard Medical School, Boston, Massachusetts, USA
    Int J Psychiatry Med 40:187-97. 2010
    ..To assess the operating characteristics of the Beck-Depression Inventory-II (BDI-II) and the BDI-II cognitive subscale (BDI-II-cog) in screening for major depression (MDD) in post-myocardial infarction (MI) patients...
  72. doi New York Heart Association class versus amino-terminal pro-B type natriuretic peptide for acute heart failure prognosis
    Aaron L Baggish
    Cardiology Division, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Biomarkers 15:307-14. 2010
    ..The prognostic value of the New York Heart Association classification (NYHAC) in acutely decompensated heart failure (ADHF) is unknown...
  73. ncbi Amino-terminal pro-brain natriuretic peptide: a biomarker for diagnosis, prognosis and management of heart failure
    Angela M Morello
    Massachusetts General Hospital and Harvard Medical School, Department of Medicine, Boston, MA 02114, USA
    Expert Rev Mol Diagn 6:649-62. 2006
    ....
  74. doi Adequacy of endogenous erythropoietin levels and mortality in anaemic heart failure patients
    Peter van der Meer
    Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
    Eur Heart J 29:1510-5. 2008
    ..We examined the adequacy of endogenous erythropoietin (EPO) levels for the degree of anaemia in patients with chronic heart failure (CHF) and its relation to prognosis...
  75. pmc Relation of natriuretic peptides and midregional proadrenomedullin to cardiac chamber volumes by computed tomography in patients without heart failure: from the ROMICAT Trial
    Quynh A Truong
    Cardiac MR PET CT Program, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Clin Chem 56:651-60. 2010
    ....
  76. doi Serum levels of the interleukin-1 receptor family member ST2, cardiac structure and function, and long-term mortality in patients with acute dyspnea
    Ravi V Shah
    Department of Medicine, Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Circ Heart Fail 2:311-9. 2009
    ....
  77. doi Impact of a depression care management program for hospitalized cardiac patients
    Jeff C Huffman
    Harvard Medical School, Boston, MA, USA
    Circ Cardiovasc Qual Outcomes 4:198-205. 2011
    ..Collaborative care depression management programs have been used in outpatients to improve depression outcomes, but such a program had never been initiated in the hospital or used for patients with a wide range of cardiac illnesses...
  78. doi A collaborative care depression management program for cardiac inpatients: depression characteristics and in-hospital outcomes
    Jeff C Huffman
    Harvard Medical School, Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
    Psychosomatics 52:26-33. 2011
    ..Depression in cardiac patients is common, under-recognized, and independently associated with mortality...
  79. doi Anxiety, independent of depressive symptoms, is associated with in-hospital cardiac complications after acute myocardial infarction
    Jeff C Huffman
    Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
    J Psychosom Res 65:557-63. 2008
    ..The aim of this exploratory study was to determine whether post-MI anxiety was associated with in-hospital cardiac complications, independent of depressive symptoms...
  80. ncbi Usefulness of aminoterminal pro-brain natriuretic peptide testing for the diagnostic and prognostic evaluation of dyspneic patients with diabetes mellitus seen in the emergency department (from the PRIDE Study)
    Michelle O'Donoghue
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Am J Cardiol 100:1336-40. 2007
    ..09 to 10.7, p <0.001). In conclusion, NT-pro-BNP testing offers valuable diagnostic and prognostic information in the evaluation of dyspneic patients with DM in the ED, using identical cutpoints as the population as whole...
  81. pmc Rapid screening for major depression in post-myocardial infarction patients: an investigation using Beck Depression Inventory II items
    J C Huffman
    Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Heart 92:1656-60. 2006
    ..To determine the ability of three questions from the Beck Depression Inventory II (BDI-II) to detect major depressive disorder (MDD) in a cohort of patients hospitalised for acute myocardial infarction (MI)...
  82. ncbi Advances in heart failure: natriuretic peptide testing
    S U Rehman
    Department of Medicine and Division of Cardiology, Harvard Medical School and Massachusetts, General Hospital, Boston, MA 02114, USA
    Panminerva Med 50:139-51. 2008
    ..The ultimate goal is to recognize more readily and treat the syndrome that is HF, in order to reduce the considerable morbidity and mortality among those so afflicted...
  83. ncbi Heparin induced thrombocytopenia: diagnosis and contemporary antithrombin management
    J L Januzzi
    Cardiology Division, Massachusetts General Hospital, Harvard Medical School Boston, Massachusetts 02114, USA
    J Thromb Thrombolysis 7:259-64. 1999
    ..Among several agents, the direct antithrombins, such as r-hirudin and argatroban, look the most promising for acute treatment...
  84. ncbi When renal and cardiac insufficiencies intersect: is there a role for natriuretic peptide testing in the 'cardio-renal syndrome'?
    Roland R J van Kimmenade
    Eur Heart J 28:2960-1. 2007
  85. doi Society of Chest Pain Centers Recommendations for the evaluation and management of the observation stay acute heart failure patient: a report from the Society of Chest Pain Centers Acute Heart Failure Committee
    W Frank Peacock
    Crit Pathw Cardiol 7:83-6. 2008
  86. ncbi Usefulness of intermediate amino-terminal pro-brain natriuretic peptide concentrations for diagnosis and prognosis of acute heart failure
    Roland R J van Kimmenade
    Department of Cardiology, University Hospital Maastricht, Maastricht, The Netherlands
    Am J Cardiol 98:386-90. 2006
    ..Mortality rates in subjects with intermediate NT-pro-BNP concentrations are lower than in those with NT-pro-BNP concentrations diagnostic for HF but are higher than in subjects with NT-pro-BNP concentrations less than the gray zone...
  87. ncbi Meta-analysis of ischemia-modified albumin to rule out acute coronary syndromes in the emergency department
    Frank Peacock
    Department of Emergency Medicine, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Am Heart J 152:253-62. 2006
    ..Ischemia-modified albumin (IMA), a serum biomarker with a high negative predictive value (NPV) at ED presentation, may exclude ACS. Our objective was to perform a meta-analysis of IMA use for ACS risk stratification...
  88. ncbi Utility of amino-terminal pro-brain natriuretic peptide, galectin-3, and apelin for the evaluation of patients with acute heart failure
    Roland R van Kimmenade
    Department of Cardiology, University Hospital Maastricht, Maastricht, The Netherlands
    J Am Coll Cardiol 48:1217-24. 2006
    ..This study sought to explore the role of new biomarkers in heart failure (HF)...
  89. ncbi Effect of body mass index on diagnostic and prognostic usefulness of amino-terminal pro-brain natriuretic peptide in patients with acute dyspnea
    Antoni Bayes-Genis
    Department of Cardiology, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma, Barcelona, Spain
    Arch Intern Med 167:400-7. 2007
    ..An inverse relationship between body mass index (BMI); (calculated as weight in kilograms divided by height in meters squared) and NT-proBNP concentrations has been described...
  90. ncbi Prognostic role of transesophageal echocardiography in acute type A aortic dissection
    Eduardo Bossone
    National Research Council, Lecce, Italy
    Am Heart J 153:1013-20. 2007
    ..The prognostic significance of specific findings on imaging studies is less well described. We sought to identify the prognostic value of transesophageal echocardiography (TEE) in medically and surgically treated patients with AAD...
  91. doi Understanding amino-terminal pro-B-type natriuretic peptide in obesity
    Antoni Bayes-Genis
    Cardiology Service, Hospital Santa Creu i Sant Pau, Barcelona, Spain
    Am J Cardiol 101:89-94. 2008
    ..Thus, despite the BMI-related NP handicap observed in overweight and obese patients, NT-proBNP remains powerfully useful for diagnostic and prognostic evaluation across the entire range of BMI values...
  92. doi Amino-terminal pro-B-type natriuretic peptide testing for inpatient monitoring and treatment guidance of acute destabilized heart failure
    Paulo Bettencourt
    Servico de Medicina Interna, Hospital S João Alameda Hernani Monteiro, Porto, Portugal
    Am J Cardiol 101:67-71. 2008
    ..In those patients without a decrease in NT-proBNP despite perceived recompensation from HF, a review of adequacy of treatment, goals of therapy, and consideration of prognosis is recommended...
  93. doi Importance and interpretation of intermediate (gray zone) amino-terminal pro-B-type natriuretic peptide concentrations
    Roland R J van Kimmenade
    Department of Cardiology, Academic Hospital, Maastricht, The Netherlands
    Am J Cardiol 101:39-42. 2008
    ..Regardless of the cause, it should not be ignored because it is a "negative" result. Patients with a gray zone NT-proBNP value are at higher risk for hazard compared with those with a negative NT-proBNP result...
  94. ncbi Acute type B aortic dissection: does aortic arch involvement affect management and outcomes? Insights from the International Registry of Acute Aortic Dissection (IRAD)
    Thomas T Tsai
    University of Michigan Cardiovascular Center, 1500 E Medical Center Dr, Ann Arbor, MI 48109 5853, USA
    Circulation 116:I150-6. 2007
    ..However, the treatment of TB-AAD with aortic arch involvement (AAI) remains an unresolved issue...