Ik Kyung Jang

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc Comparison between integrated backscatter intravascular ultrasound and 64-slice multi-detector row computed tomography for tissue characterization and volumetric assessment of coronary plaques
    Takahiko Yamaki
    Department of Cardiology, Gifu University Graduate School of Medicine, Yanagido, Japan
    Cardiovasc Ultrasound 10:33. 2012
  2. ncbi request reprint Argatroban anticoagulation in conjunction with glycoprotein IIb/IIIa inhibition in patients undergoing percutaneous coronary intervention: an open-label, nonrandomized pilot study
    Ik Kyung Jang
    Cardiology Division, Gray Bigelow 800, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
    J Thromb Thrombolysis 18:31-7. 2004
  3. pmc In vivo characterization of coronary atherosclerotic plaque by use of optical coherence tomography
    Ik Kyung Jang
    Cardiology Division, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Circulation 111:1551-5. 2005
  4. ncbi request reprint When heparins promote thrombosis: review of heparin-induced thrombocytopenia
    Ik Kyung Jang
    Massachusetts General Hospital and Harvard Medical School, Boston, Mass 02114, USA
    Circulation 111:2671-83. 2005
  5. ncbi request reprint Argatroban therapy in women with heparin-induced thrombocytopenia
    Ik Kyung Jang
    Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Womens Health (Larchmt) 16:895-901. 2007
  6. ncbi request reprint A randomized, double-blind, placebo-controlled study of the safety and efficacy of intravenous MCC-135 as an adjunct to primary percutaneous coronary intervention in patients with acute myocardial infarction: Evaluation of MCC-135 for left ventricular sal
    Ik Kyung Jang
    Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Am Heart J 155:113.e1-8. 2008
  7. ncbi request reprint A randomized, double-blind, placebo-controlled study of the safety and efficacy of intravenous MCC-135 as an adjunct to primary percutaneous coronary intervention in patients with acute myocardial infarction: rationale and design of the evaluation of MCC-
    Ik Kyung Jang
    Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Thromb Thrombolysis 20:147-53. 2005
  8. ncbi request reprint Characterization of human atherosclerosis by optical coherence tomography
    Hiroshi Yabushita
    Cardiology Division, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Circulation 106:1640-5. 2002
  9. ncbi request reprint Comparison of sixty-four-slice multidetector computed tomographic coronary angiography to coronary angiography with intravascular ultrasound for the detection of transplant vasculopathy
    Shawn A Gregory
    Cardiology Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Am J Cardiol 98:877-84. 2006
  10. pmc Relationship between a systemic inflammatory marker, plaque inflammation, and plaque characteristics determined by intravascular optical coherence tomography
    O Christopher Raffel
    Cardiology Division, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Arterioscler Thromb Vasc Biol 27:1820-7. 2007

Detail Information

Publications104 found, 100 shown here

  1. pmc Comparison between integrated backscatter intravascular ultrasound and 64-slice multi-detector row computed tomography for tissue characterization and volumetric assessment of coronary plaques
    Takahiko Yamaki
    Department of Cardiology, Gifu University Graduate School of Medicine, Yanagido, Japan
    Cardiovasc Ultrasound 10:33. 2012
    ....
  2. ncbi request reprint Argatroban anticoagulation in conjunction with glycoprotein IIb/IIIa inhibition in patients undergoing percutaneous coronary intervention: an open-label, nonrandomized pilot study
    Ik Kyung Jang
    Cardiology Division, Gray Bigelow 800, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
    J Thromb Thrombolysis 18:31-7. 2004
    ..This multicenter, prospective pilot study evaluated the efficacy and safety of argatroban in combination with glycoprotein IIb/IIIa inhibition in patients undergoing percutaneous coronary intervention...
  3. pmc In vivo characterization of coronary atherosclerotic plaque by use of optical coherence tomography
    Ik Kyung Jang
    Cardiology Division, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Circulation 111:1551-5. 2005
    ..Optical coherence tomography (OCT) is a high-resolution ( approximately 10 microm), catheter-based imaging modality capable of investigating detailed coronary plaque morphology in vivo...
  4. ncbi request reprint When heparins promote thrombosis: review of heparin-induced thrombocytopenia
    Ik Kyung Jang
    Massachusetts General Hospital and Harvard Medical School, Boston, Mass 02114, USA
    Circulation 111:2671-83. 2005
  5. ncbi request reprint Argatroban therapy in women with heparin-induced thrombocytopenia
    Ik Kyung Jang
    Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Womens Health (Larchmt) 16:895-901. 2007
    ..We compared gender differences for treatment and outcomes in HIT patients administered argatroban therapy...
  6. ncbi request reprint A randomized, double-blind, placebo-controlled study of the safety and efficacy of intravenous MCC-135 as an adjunct to primary percutaneous coronary intervention in patients with acute myocardial infarction: Evaluation of MCC-135 for left ventricular sal
    Ik Kyung Jang
    Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Am Heart J 155:113.e1-8. 2008
    ....
  7. ncbi request reprint A randomized, double-blind, placebo-controlled study of the safety and efficacy of intravenous MCC-135 as an adjunct to primary percutaneous coronary intervention in patients with acute myocardial infarction: rationale and design of the evaluation of MCC-
    Ik Kyung Jang
    Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Thromb Thrombolysis 20:147-53. 2005
    ..The rationale, design, and methods of the EVOLVE study, along with two sub-studies, are described in this paper...
  8. ncbi request reprint Characterization of human atherosclerosis by optical coherence tomography
    Hiroshi Yabushita
    Cardiology Division, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Circulation 106:1640-5. 2002
    ..The aim of this study was to establish objective OCT image criteria for atherosclerotic plaque characterization in vitro...
  9. ncbi request reprint Comparison of sixty-four-slice multidetector computed tomographic coronary angiography to coronary angiography with intravascular ultrasound for the detection of transplant vasculopathy
    Shawn A Gregory
    Cardiology Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Am J Cardiol 98:877-84. 2006
    ..Further, MDCT measurements of lumen diameters correlated well with quantitative coronary angiography...
  10. pmc Relationship between a systemic inflammatory marker, plaque inflammation, and plaque characteristics determined by intravascular optical coherence tomography
    O Christopher Raffel
    Cardiology Division, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Arterioscler Thromb Vasc Biol 27:1820-7. 2007
    ....
  11. ncbi request reprint Predictors for neoatherosclerosis: a retrospective observational study from the optical coherence tomography registry
    Taishi Yonetsu
    Cardiology Division, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, USA
    Circ Cardiovasc Imaging 5:660-6. 2012
    ..Recent studies have reported development of neoatherosclerosis (NA) inside the stents several years after stent implantation. The aim of this study was to determine the predictors for NA using optical coherence tomography...
  12. doi request reprint Comparison of incidence and time course of neoatherosclerosis between bare metal stents and drug-eluting stents using optical coherence tomography
    Taishi Yonetsu
    Division of Cardiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Am J Cardiol 110:933-9. 2012
    ..In conclusion, lipid-rich neoatherosclerosis develops inside stents earlier in DESs than in BMSs. After 48 months, most restenotic stents will have developed lipid-laden neointima in both groups...
  13. doi request reprint Correlation between degree of neointimal hyperplasia and incidence and characteristics of neoatherosclerosis as assessed by optical coherence tomography
    Rocco Vergallo
    Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts
    Am J Cardiol 112:1315-21. 2013
    ..This association is independent from stent type and time from implantation and suggests a possible pathogenic link between the two processes...
  14. doi request reprint Reperfused myocardial infarction: contrast-enhanced 64-Section CT in comparison to MR imaging
    Koen Nieman
    Cardiac MRI PET CT Program, Department of Radiology and the Cardiology Division, Massachusetts General Hospital and Harvard Medical School, 165 Cambridge St, Boston, MA 02114, USA
    Radiology 247:49-56. 2008
    ..To prospectively compare 64-section multidetector computed tomography (CT) and cardiac magnetic resonance (MR) imaging for the early assessment of myocardial enhancement and infarct size after acute reperfused myocardial infarction (MI)...
  15. ncbi request reprint Prevalence of heparin-induced thrombocytopenia in patients undergoing cardiac catheterization
    Shi Yin Foo
    Cardiology Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Am Heart J 152:290.e1-7. 2006
    ..The objective was to examine prospectively the prevalence of anti-platelet factor 4 (PF4)/heparin antibodies and heparin-induced thrombocytopenia in the population undergoing cardiac catheterization...
  16. ncbi request reprint Comparison of measurement of cross-sectional coronary atherosclerotic plaque and vessel areas by 16-slice multidetector computed tomography versus intravascular ultrasound
    Fabian Moselewski
    Division of Cardiology, Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Am J Cardiol 94:1294-7. 2004
    ..The mean luminal area and mean plaque area were slightly but significantly overestimated with MDCT. MDCT permits the noninvasive measurement of coronary cross-sectional luminal and plaque areas with moderate accuracy...
  17. ncbi request reprint Calcium concentration of individual coronary calcified plaques as measured by multidetector row computed tomography
    Fabian Moselewski
    Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Mass 02114, USA
    Circulation 111:3236-41. 2005
    ..In this study, therefore, we assessed the characteristics of individual calcified plaques and their relationship to other parameters derived from CT analysis of coronary calcium in a community-based cross-sectional cohort...
  18. ncbi request reprint Tirofiban therapy for patients with acute coronary syndromes and prior coronary artery bypass grafting in the PRISM-PLUS trial
    Stephen J Servoss
    Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Am J Cardiol 93:843-7. 2004
    ..1% vs 48.6%, p = 0.057). Bleeding rates were similar in patients with and without prior CABG. Tirofiban was well tolerated and tended to decrease the considerable risk for ischemic ACS complications in patients with prior CABG...
  19. ncbi request reprint Noninvasive assessment of plaque morphology and composition in culprit and stable lesions in acute coronary syndrome and stable lesions in stable angina by multidetector computed tomography
    Udo Hoffmann
    Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Am Coll Cardiol 47:1655-62. 2006
    ..The purpose of this study was to assess morphology and composition of culprit and stable coronary lesions by multidetector computed tomography (MDCT)...
  20. ncbi request reprint Accuracy of 16-slice multi-detector CT to quantify the degree of coronary artery stenosis: assessment of cross-sectional and longitudinal vessel reconstructions
    Ricardo C Cury
    Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA
    Eur J Radiol 57:345-50. 2006
    ..The purpose of this study was to determine the accuracy of MDCT to quantify the degree of coronary stenosis as compared to quantitative coronary angiography (QCA) using two different reconstruction methods...
  21. ncbi request reprint The sensitivity of cardiac markers stratified by symptom duration
    John T Nagurney
    Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Emerg Med 29:409-15. 2005
    ..For troponin I, the increase in sensitivity approaches threefold...
  22. ncbi request reprint Efficacy and safety of argatroban with or without glycoprotein IIb/IIIa inhibitor in patients with heparin induced thrombocytopenia undergoing percutaneous coronary intervention for acute coronary syndrome
    Ignacio Cruz-Gonzalez
    Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Gray Bigelow 800, 55 Fruit Street, Boston, MA 02114, USA
    J Thromb Thrombolysis 25:214-8. 2008
    ....
  23. ncbi request reprint Threshold-dependent variability of coronary artery calcification measurements -- implications for contrast-enhanced multi-detector row-computed tomography
    Fabian Moselewski
    Division of Cardiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Eur J Radiol 57:390-5. 2006
    ..The present study investigated the threshold-dependent variability of coronary artery calcification (CAC) measurements and the potential to quantify CAC in contrast-enhanced multi-detector row-computed tomography (MDCT)...
  24. doi request reprint Nonculprit coronary plaque characteristics of chronic kidney disease
    Koji Kato
    Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Circ Cardiovasc Imaging 6:448-56. 2013
    ..The aim of the present study was to compare the coronary plaque characteristics of patients with and without CKD using optical coherence tomography...
  25. ncbi request reprint Benefits and safety of tirofiban among acute coronary syndrome patients with mild to moderate renal insufficiency: results from the Platelet Receptor Inhibition in Ischemic Syndrome Management in Patients Limited by Unstable Signs and Symptoms (PRISM-PLUS
    James L Januzzi
    Cardiology Division, Massachusetts General Hospital, Boston, MA, USA
    Circulation 105:2361-6. 2002
    ..The role of glycoprotein IIb/IIIa receptor antagonists for the treatment of patients with acute coronary syndrome and renal insufficiency remains undefined...
  26. ncbi request reprint Differentiation of recent and chronic myocardial infarction by cardiac computed tomography
    Koen Nieman
    Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Am J Cardiol 98:303-8. 2006
    ..05), whereas recent MI was not (p > 0.05). In conclusion, recent and long-standing MIs may be differentiated by computed tomography based on myocardial CT attenuation values and ventricular dimensions...
  27. ncbi request reprint Detection of calcified and noncalcified coronary atherosclerotic plaque by contrast-enhanced, submillimeter multidetector spiral computed tomography: a segment-based comparison with intravascular ultrasound
    Stephan Achenbach
    Department of Radiology, Massachusetts General Hospital, Boston, USA
    Circulation 109:14-7. 2004
    ..We investigated the ability of multidetector spiral computed tomography (MDCT) to detect atherosclerotic plaque in nonstenotic coronary arteries...
  28. pmc In vivo diagnosis of plaque erosion and calcified nodule in patients with acute coronary syndrome by intravascular optical coherence tomography
    Haibo Jia
    Department of Cardiology, The 2nd Affiliated Hospital of Harbin Medical University, The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts
    J Am Coll Cardiol 62:1748-58. 2013
    ..The aim of this study was to characterize the morphological features of plaque erosion and calcified nodule in patients with acute coronary syndrome (ACS) by optical coherence tomography (OCT)...
  29. ncbi request reprint Optical coherence tomography as a tool for percutaneous coronary interventions
    Larry J Diaz-Sandoval
    Cardiology Division and Cardiovascular Clinical Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Catheter Cardiovasc Interv 65:492-6. 2005
    ..This is the first report of the use of OCT to identify in vivo human intracoronary pathology after PCI...
  30. ncbi request reprint Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: comparison with intravascular ultrasound
    Ik Kyung Jang
    Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Am Coll Cardiol 39:604-9. 2002
    ..The aim of this study was to evaluate the feasibility and the ability of intravascular optical coherence tomography (OCT) to visualize the components of coronary plaques in living patients...
  31. ncbi request reprint Predictors for the development of elevated anti-heparin/platelet factor 4 antibody titers in patients undergoing cardiac catheterization
    Robert W Yeh
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Am J Cardiol 98:419-21. 2006
    ..It is possible to identify patients at high risk for developing elevated titers of antiheparin/PF4 antibodies on the basis of their baseline clinical characteristics...
  32. ncbi request reprint Intravascular modalities for detection of vulnerable plaque: current status
    Briain D Macneill
    Cardiology Division, Massachusetts General Hospital and Harvard Medical School, Boston, Mass 02114, USA
    Arterioscler Thromb Vasc Biol 23:1333-42. 2003
    ..In this review, we will discuss these techniques, their relative advantages and limitations, and their potential clinical application...
  33. ncbi request reprint Diagnostic accuracy of optical coherence tomography and integrated backscatter intravascular ultrasound images for tissue characterization of human coronary plaques
    Masanori Kawasaki
    Wellman Laboratories of Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Am Coll Cardiol 48:81-8. 2006
    ....
  34. ncbi request reprint In vivo volumetric analysis of coronary stent using optical coherence tomography with a novel balloon occlusion-flushing catheter: a comparison with intravascular ultrasound
    Yoshiaki Kawase
    Cardiology Laboratory for Integrative Physiology and Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Ultrasound Med Biol 31:1343-9. 2005
    ..Although OCT underestimates the stent strut thickness, motorized pullback OCT imaging with the occlusion catheter can provide appropriate in-stent images in the porcine coronary arteries...
  35. doi request reprint Nonculprit plaques in patients with acute coronary syndromes have more vulnerable features compared with those with non-acute coronary syndromes: a 3-vessel optical coherence tomography study
    Koji Kato
    Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Circ Cardiovasc Imaging 5:433-40. 2012
    ..The aim of this study was to compare the plaque characteristics of nonculprit lesions between ACS and non-ACS patients using optical coherence tomography (OCT) imaging...
  36. ncbi request reprint Utility of cardiovascular magnetic resonance to predict left ventricular recovery after primary percutaneous coronary intervention for patients presenting with acute ST-segment elevation myocardial infarction
    Michael D Shapiro
    Cardiac MR PET CT Program, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Am J Cardiol 100:211-6. 2007
    ..90, 95% CI 0.58 to 1.40, p = 0.64). In conclusion, when using the delayed enhancement technique for assessment of DHE and MVO, degree of infarct transmurality appears to be a more powerful predictor of LV recovery by CMR...
  37. ncbi request reprint Comparison of the degree of coronary stenoses by multidetector computed tomography versus by quantitative coronary angiography
    Ricardo C Cury
    Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Am J Cardiol 96:784-7. 2005
    ..The correlation between MDCT and QCA was moderate with respect to lesion length (r2 = 0.54). In the absence of severe calcifications or motion artifacts, MDCT permits noninvasive quantification of coronary stenosis...
  38. doi request reprint Efficacy and safety of argatroban in patients with heparin induced thrombocytopenia undergoing endovascular intervention for peripheral arterial disease
    Suzanne J Baron
    Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Catheter Cardiovasc Interv 72:116-20. 2008
    ..This study aimed to evaluate the efficacy and safety of argatroban during percutaneous interventions for peripheral arterial disease (PAD)...
  39. ncbi request reprint Predictive value of 16-slice multidetector spiral computed tomography to detect significant obstructive coronary artery disease in patients at high risk for coronary artery disease: patient-versus segment-based analysis
    Udo Hoffmann
    Department of Radiology, Massachusetts General Hospital, 100 Charles River Plaza, Ste 400, Boston, MA 02114, USA
    Circulation 110:2638-43. 2004
    ....
  40. ncbi request reprint Quantification of macrophage content in atherosclerotic plaques by optical coherence tomography
    Guillermo J Tearney
    Wellman Laboratories of Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, Mass 02114, USA
    Circulation 107:113-9. 2003
    ..The aim of this study was to investigate the use of OCT for identifying macrophages in fibrous caps...
  41. doi request reprint Comparison of nonculprit coronary plaque characteristics between patients with and without diabetes: a 3-vessel optical coherence tomography study
    Koji Kato
    Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    JACC Cardiovasc Interv 5:1150-8. 2012
    ..The aim of the present study was to compare the characteristics of nonculprit coronary plaques between diabetes mellitus (DM) and non-DM patients using 3-vessel optical coherence tomography (OCT) imaging...
  42. doi request reprint Hyperglycemia on admission predicts larger infarct size in patients undergoing percutaneous coronary intervention for acute ST-segment elevation myocardial infarction
    Ignacio Cruz-Gonzalez
    Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Gray Bigelow 800, Boston, MA 02114, USA
    Diabetes Res Clin Pract 88:97-102. 2010
    ....
  43. doi request reprint Utility of cardiac biomarkers in predicting infarct size, left ventricular function, and clinical outcome after primary percutaneous coronary intervention for ST-segment elevation myocardial infarction
    Stanley Chia
    Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    JACC Cardiovasc Interv 1:415-23. 2008
    ....
  44. doi request reprint Association of leukocyte and neutrophil counts with infarct size, left ventricular function and outcomes after percutaneous coronary intervention for ST-elevation myocardial infarction
    Stanley Chia
    Heart Center, Massachusetts General Hospital, Boston, MA, USA
    Am J Cardiol 103:333-7. 2009
    ....
  45. ncbi request reprint Analysis of cardiac dimensions, mass and function in heart transplant recipients using 64-slice multi-detector computed tomography
    Maros Ferencik
    Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Heart Lung Transplant 26:478-84. 2007
    ..The aim of this study was to compare 64-slice MDCT analysis of cardiac structure and function to 2-dimensional echocardiography in heart transplant recipients...
  46. doi request reprint Pancoronary plaque vulnerability in patients with acute coronary syndrome and ruptured culprit plaque: A 3-vessel optical coherence tomography study
    Rocco Vergallo
    Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA
    Am Heart J 167:59-67. 2014
    ..In light of the systemic nature of atherosclerosis, we hypothesized that nonculprit plaques might also express different morphological features in these 2 groups of patients...
  47. ncbi request reprint Prophylaxis of contrast-induced nephropathy in patients undergoing coronary angiography
    Briain D Macneill
    Cardiology Division, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Catheter Cardiovasc Interv 60:458-61. 2003
    ..32% for placebo; P = 0.046). In patients with mild to moderate renal impairment undergoing cardiac catheterization, prophylactic treatment with oral acetylcysteine reduces the incidence of contrast-induced nephropathy...
  48. ncbi request reprint Coronary stent malapposition as a result of a post-stenotic aneurysm detected by optical coherence tomography
    O Christopher Raffel
    Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Invasive Cardiol 18:561-2. 2006
    ..We describe a case of coronary stent malapposition as a result of a post-stenotic aneurysm. Both the malapposition and its etiology were clearly demonstrated by optical coherence tomography, a novel high-resolution imaging technology...
  49. ncbi request reprint Assessment of coronary remodeling in stenotic and nonstenotic coronary atherosclerotic lesions by multidetector spiral computed tomography
    Stephan Achenbach
    Department of Radiology, Massachusetts General Hospital, Boston, MA, USA
    J Am Coll Cardiol 43:842-7. 2004
    ..This study was designed to investigate whether contrast-enhanced multidetector spiral CT (MDCT) permits assessment of remodeling in coronary atherosclerotic lesions...
  50. ncbi request reprint Clinician update: direct thrombin inhibitors in acute coronary syndromes
    Joanna J Wykrzykowska
    Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Thromb Thrombolysis 15:47-57. 2003
    ..As the knowledge of more appropriate use of these drugs progressed, there is a renewed interest in DTIs. Herein we will review the clinical studies assessing hirudin, bivalirudin and argatroban in the settings of AMI, UA and PCI...
  51. doi request reprint Safety and efficacy of the argatroban therapy during the early post-cardiac surgery period
    Joo Heung Yoon
    Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Bigelow 800, 55 Fruit Street, Boston, MA, 02114, USA
    J Thromb Thrombolysis 30:276-80. 2010
    ..In cardiac surgery patients with clinical suspicion of HIT, early postoperative use of argatroban seems well-tolerated and associated with a low risk of thrombotic events...
  52. pmc In vivo characterisation of coronary plaques with conventional grey-scale intravascular ultrasound: correlation with optical coherence tomography
    Adrian F Low
    Cardiology Division, Massachusetts General Hospital, Boston, MA, USA
    EuroIntervention 4:626-32. 2009
    ..The aim of this study was to evaluate the ability of conventional grey-scale IVUS in identifying in vivo coronary plaque characteristics, in particular lipid content as a marker of the vulnerable plaque, when compared to OCT...
  53. doi request reprint The triple work-up for emergency department patients with acute chest pain: how often does it occur?
    Jonathan G Rogg
    Tufts University School of Medicine, Boston, Massachusetts, USA
    J Emerg Med 40:128-34. 2011
    ..To measure the degree of overlap and diagnostic yield for evaluations of acute coronary syndrome (ACS), pulmonary embolism (PE), and aortic dissection (AD) among Emergency Department (ED) patients...
  54. ncbi request reprint Comparison of two different methods of quantitative coronary angiography in patients with acute coronary syndromes
    Boris V Sheynberg
    Cardiology Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Catheter Cardiovasc Interv 55:442-9. 2002
    ..49 +/- 0.61 vs. 2.11 +/- 0.74; P < 0.05). Thus, GFT appears to improve analysis of complex lesions compared to MCA. GFTs role in angiographic trials and clinical practice deserves further study...
  55. ncbi request reprint Focal and multi-focal plaque macrophage distributions in patients with acute and stable presentations of coronary artery disease
    Briain D Macneill
    Cardiology Division, Harvard Medical School, Boston, Massachusetts, USA
    J Am Coll Cardiol 44:972-9. 2004
    ..This study was designed to utilize optical coherence tomography (OCT) images of coronary atherosclerotic plaque macrophages to investigate the relationship between macrophage distributions and clinical syndrome...
  56. pmc Comprehensive assessment of myocardial perfusion defects, regional wall motion, and left ventricular function by using 64-section multidetector CT
    Ricardo C Cury
    Department of Radiology, Cardiac MR PET CT Program, Massachusetts General Hospital and Harvard Medical School, 165 Cambridge St, Suite 400, Boston, MA 02114, USA
    Radiology 248:466-75. 2008
    ..To evaluate the accuracy of 64-section multidetector computed tomography (CT) for the assessment of perfusion defects (PDs), regional wall motion (RWM), and global left ventricular (LV) function...
  57. ncbi request reprint In-vivo comparison of coronary plaque characteristics using optical coherence tomography in women vs. men with acute coronary syndrome
    Stanley Chia
    Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Coron Artery Dis 18:423-7. 2007
    ..Intravascular optical coherence tomography (OCT) is a high-resolution imaging technique capable of in-vivo plaque characterization. The aim of this study was to compare culprit plaque characteristics in women and men presenting with ACS...
  58. ncbi request reprint [Heparin-induced thrombocytopenia]
    Ignacio Cruz-Gonzalez
    Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Rev Esp Cardiol 60:1071-82. 2007
    ..This review contains a discussion of the diagnosis and treatment of this syndrome...
  59. ncbi request reprint Intravascular optical coherence tomography: cellular imaging
    Briain D Macneill
    Cardiology Division, Massachusetts General Hospital, Boston, MA 02114, USA
    J Nucl Cardiol 12:460-5. 2005
    ..Superimposed on this inflammatory background, local increases in macrophage content, particularly at the cap surface and at areas at high risk for rupture, further promote the instability of individual lesions...
  60. ncbi request reprint Feasibility and safety of the second-generation, frequency domain optical coherence tomography (FD-OCT): a multicenter study
    Joo Heung Yoon
    Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Invasive Cardiol 24:206-9. 2012
    ..This study sought to assess the effectiveness and safety of the second-generation frequency-domain optical coherence tomography (FD-OCT) system...
  61. pmc Comparison of coronary plaque characteristics between diabetic and non-diabetic subjects: An in vivo optical coherence tomography study
    Stanley Chia
    Cardiology Division, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street GRB 800, Boston, MA, United States
    Diabetes Res Clin Pract 81:155-60. 2008
    ..Using OCT imaging, we compared in vivo plaque characteristics between diabetic and non-diabetic subjects...
  62. pmc Association of statin therapy with reduced coronary plaque rupture: an optical coherence tomography study
    Stanley Chia
    Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Coron Artery Dis 19:237-42. 2008
    ..We aimed to demonstrate the potential utility of OCT in evaluating coronary plaques in patients with or without statin therapy...
  63. ncbi request reprint Argatroban therapy in patients with coronary artery disease and heparin-induced thrombocytopenia
    Ik Kyung Jang
    Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Cardiology 109:172-6. 2008
    ..01), and led to less bleeding (4 versus 15%, p = 0.046). Therefore, in patients with coronary artery disease who develop heparin-induced thrombocytopenia, argatroban provides safe, effective anticoagulation...
  64. ncbi request reprint Compassionate use of the amplatzer ASD closure device for residual postinfarction ventricular septal rupture following surgical repair
    Harry C Lowe
    Cardiology Division, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02144, USA
    Catheter Cardiovasc Interv 59:230-3; discussion 234. 2003
    ..Initial attempts to close the defect with the use of 28-mm and 33-mm CARDIOSEAL were unsuccessful. Closure technique, immediate and long-term follow-up outcomes are reported...
  65. pmc Optical coherence tomography for imaging the vulnerable plaque
    Guillermo J Tearney
    Wellman Center for Photomedicine, Department of Pathology, Massachusetts General Hospital, 50 Blossom Street, BAR703, Boston, Massachusetts 02114, USA
    J Biomed Opt 11:021002. 2006
    ....
  66. pmc Comprehensive volumetric optical microscopy in vivo
    Seok H Yun
    Wellman Center for Photomedicine, 55 Fruit Street, Boston, Massachusetts 02114, USA
    Nat Med 12:1429-33. 2006
    ..Our pilot study results suggest that this technology may be a useful clinical tool for comprehensive diagnostic imaging for epithelial disease and for evaluating coronary pathology and iatrogenic effects...
  67. doi request reprint Quantification of coronary stenosis by dual source computed tomography in patients: a comparative study with intravascular ultrasound and invasive angiography
    Gudrun Feuchtner
    Massachusetts General Hospital Harvard Medical School, Dept Radiology, Boston, USA
    Eur J Radiol 81:83-8. 2012
    ..To determine the accuracy of dual-source CT (DSCT) to quantify coronary stenosis compared to intravascular ultrasound (IVUS) and quantitative coronary angiography (QCA)...
  68. ncbi request reprint Non-invasive assessment of myocardial ischaemia by using low amplitude oscillations of the conventional ECG signals (ECG dispersion mapping) during percutaneous coronary intervention
    Ignacio Cruz-Gonzalez
    Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Acta Cardiol 64:11-5. 2009
    ..Therefore we performed a prospective study to assess the HeartVue 6S System for the detection of myocardial ischaemia during coronary occlusion in patients undergoing percutaneous coronary intervention (PCI)...
  69. pmc In vivo association between positive coronary artery remodelling and coronary plaque characteristics assessed by intravascular optical coherence tomography
    Owen Christopher Raffel
    Cardiology Division, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, GRB 800, Boston, MA 02114, USA
    Eur Heart J 29:1721-8. 2008
    ..OCT is a unique imaging modality capable of characterizing these important morphological features of vulnerable plaque...
  70. ncbi request reprint Comparison of activated clotting times obtained using Hemochron and Medtronic analysers in patients receiving anti-thrombin therapy during cardiac catheterisation
    Stanley Chia
    Cardiology Division, Massachusetts General Hospital, 55 Fruit Street GRB 800, Boston, MA 02114, USA
    Thromb Haemost 101:535-40. 2009
    ..Paradoxically, Medtronic ACT results were higher after argatroban therapy. Understanding this discrepancy is crucial when using ACT to guide invasive cardiac procedures...
  71. ncbi request reprint Predictors of revascularization among emergency department patients who are evaluated for acute coronary syndrome
    John T Nagurney
    Massachusetts General Hospital, Clinics 115, 55 Fruit Street, Boston, MA 02114, USA
    J Thromb Thrombolysis 19:41-6. 2005
    ..To determine, among patients who present to the emergency department with symptoms suggestive of acute coronary syndrome (ACS), predictors of short-term revascularization...
  72. doi request reprint In-hospital outcomes of emergent and elective percutaneous coronary intervention in octogenarians
    Faisal M Merchant
    Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Coron Artery Dis 20:118-23. 2009
    ..We sought to describe the short-term outcomes of octogenarians undergoing percutaneous coronary intervention (PCI) in both emergent and elective settings...
  73. doi request reprint What is the optimal anticoagulation level with argatroban during percutaneous coronary intervention?
    Ignacio Cruz-Gonzalez
    Cardiology Division, Massachusetts General Hospital, Harvard Medical School Boston, Massachusetts, USA
    Blood Coagul Fibrinolysis 19:401-4. 2008
    ..006). These results suggest that in patients undergoing percutaneous coronary intervention, argatroban provides adequate anticoagulation with a low bleeding rate, when activated clotting time is maintained below 450 s...
  74. ncbi request reprint Prevalence of heparin/platelet factor 4 antibodies before and after cardiac surgery
    Brendan M Everett
    Department of Medicine, Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Ann Thorac Surg 83:592-7. 2007
    ..We prospectively investigated whether the presence of heparin/PF4 antibodies would predict clinical thrombosis in this population...
  75. ncbi request reprint The porcine coronary model of in-stent restenosis: current status in the era of drug-eluting stents
    Harry C Lowe
    Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Catheter Cardiovasc Interv 60:515-23. 2003
    ..Finally, recent pig coronary drug-eluting stent studies are examined, with a discussion of their advantages, limitations, and possible future modifications...
  76. doi request reprint In vivo comparison of lumen dimensions measured by time domain-, and frequency domain-optical coherence tomography, and intravascular ultrasound
    Soo Joong Kim
    Cardiology Division, Massachusetts General Hospital, Harvard Medical School, GRB 800, 55 Fruit Street, Boston, MA, USA
    Int J Cardiovasc Imaging 29:967-75. 2013
    ..Vessel dimension measurements were similar between IVUS and FD-OCT in native vessel unlike with TD-OCT. Therefore, we might adapt the IVUS criteria of lesion severity for percutaneous coronary intervention to FD-OCT...
  77. doi request reprint Comparison of zotarolimus-eluting stent and everolimus-eluting stent for vascular healing response: serial 3-month and 12-month optical coherence tomography study
    Soo Joong Kim
    Department of Medicine, Cardiology Division, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
    Coron Artery Dis 24:431-9. 2013
    ..We designed a prospective study to compare the neointimal response between zotarolimus-eluting stents (ZES) and EES at 3 and 12 months using serial optical coherence tomography examinations...
  78. ncbi request reprint Comparison of nonuniform rotational distortion between mechanical IVUS and OCT using a phantom model
    Yoshiaki Kawase
    Cardiology Laboratory of Integrative Physiology and Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Ultrasound Med Biol 33:67-73. 2007
    ..1 +/- 0.9 degrees vs. 6.9 +/- 2.1 degrees , p < 0.05) but not with OCT (3.5 +/- 0.8 degrees vs. 3.2 +/- 1.0 degrees , p= not significant). OCT generates significantly less NURD compared with M-IVUS, especially in tortuous situation...
  79. ncbi request reprint Intracoronary imaging modalities for vulnerable plaques
    Koji Kato
    Cardiology Division, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Nippon Med Sch 78:340-51. 2011
    ..Moreover OCT has a unique ability of detecting macrophages. In this review, we attempted to summarize the advantages and limitations of the currently available intravascular modalities...
  80. doi request reprint Assessment of nonstenotic coronary lesions by 64-slice multidetector computed tomography in comparison to intravascular ultrasound: evaluation of nonculprit coronary lesions
    Milena Petranovic
    Department of Radiology, Massachusetts General Hospital, 165 Cambridge Street Suite 400, Boston, MA 02114, USA
    J Cardiovasc Comput Tomogr 3:24-31. 2009
    ..Multidetector computed tomography (MDCT) has recently emerged as a potential noninvasive alternative for high-resolution imaging of coronary arteries...
  81. doi request reprint The new and old definitions of acute myocardial infarction: a data-based comparison
    John Tobias Nagurney
    Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Emerg Med 26:523-31. 2008
    ....
  82. ncbi request reprint Optical coherence tomography– 15 years in cardiology
    Taishi Yonetsu
    Cardiology Division, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Circ J 77:1933-40. 2013
    ..Prospective data are needed to prove that the use of OCT improves patient outcomes, which is the ultimate goal of any clinical diagnostic tool...
  83. doi request reprint Heparin-induced thrombocytopenia in cardiovascular patients: pathophysiology, diagnosis, and treatment
    Joo Heung Yoon
    Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Cardiol Rev 19:143-53. 2011
    ..Therefore, this review will focus on the updated pathophysiology of heparin-induced thrombocytopenia, new diagnostic criteria, and the various treatment options for cardiovascular patients with different conditions...
  84. doi request reprint Clinical evaluation of the i-STAT kaolin activated clotting time (ACT) test in different clinical settings in a large academic urban medical center: comparison with the Medtronic ACT Plus
    Elizabeth Lee Lewandrowski
    Department of Pathology, Massachusetts General Hospital, USA
    Am J Clin Pathol 135:741-8. 2011
    ..94, indicating statistically significant correlation between the 2 methods. Based on this comparison, we were able to implement the i-STAT ACT throughout our institution without changing target ranges for any individual procedure...
  85. ncbi request reprint Acute coronary syndrome is a common clinical presentation of in-stent restenosis
    Darren L Walters
    Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Am J Cardiol 89:491-4. 2002
    ....
  86. ncbi request reprint The effect of glycoprotein IIb/IIIa receptor inhibitor on the microcirculation in patients undergoing high-risk coronary stenting; a prospective, randomized study
    Philip Wong
    Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Thromb Thrombolysis 16:163-6. 2003
    ..We evaluated the effect of the glycoprotein IIb/IIIa inhibitor, tirofiban, on the microcirculation measured by Doppler coronary flow reserve (CFR) in patients undergoing high-risk coronary stenting...
  87. ncbi request reprint Technology Insight: optical coherence tomography--current status and future development
    Adrian F Low
    Cardiology Division at the Massachusetts General Hospital, Boston, MA 02114, USA
    Nat Clin Pract Cardiovasc Med 3:154-62; quiz 172. 2006
    ..Here, we discuss results from clinical studies which indicate that optical coherence tomography is a promising imaging technique for improved characterization of the coronary atherosclerotic plaque...
  88. doi request reprint Optical coherence tomography: basics, current application and future potential
    Farhad Abtahian
    Cardiology Division, Massachusetts General Hospital, YAW 5700, Boston, MA 02114, USA
    Curr Opin Pharmacol 12:583-91. 2012
    ..This review is intended to give an overview of the current investigational uses of OCT and its potential roles as the technology matures...
  89. pmc Coronary computed tomography angiography for early triage of patients with acute chest pain: the ROMICAT (Rule Out Myocardial Infarction using Computer Assisted Tomography) trial
    Udo Hoffmann
    Cardiac MR PET CT Program, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Am Coll Cardiol 53:1642-50. 2009
    ..This study was designed to determine the usefulness of coronary computed tomography angiography (CTA) in patients with acute chest pain...
  90. ncbi request reprint Argatroban
    Sekar Kathiresan
    Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Thromb Thrombolysis 13:41-7. 2002
    ..The role of adjunctive argatroban therapy in acute coronary syndromes and during percutaneous coronary intervention is currently being studied...
  91. ncbi request reprint Incidental finding of a ruptured thin-cap fibroatheroma by optical coherence tomography
    Owen Christopher Raffel
    Cardiology Division, Massachusetts General Hospital and Harvard Medical School, GRB 800, Boston, MA 02114, USA
    Eur Heart J 27:2393. 2006
  92. ncbi request reprint Argatroban: update
    Robert W Yeh
    Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Am Heart J 151:1131-8. 2006
    ..Small studies have demonstrated a potential role for its use in ischemic stroke and hemodialysis. Additional studies are warranted to confirm argatroban's efficacy in a wide variety of clinical settings...
  93. ncbi request reprint Coronary CT angiography
    Susanna I Lee
    Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA
    J Am Coll Radiol 3:560-4. 2006
  94. ncbi request reprint Pharmacologic reperfusion therapy for acute myocardial infarction
    Harry C Lowe
    Cardiology Division, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Thromb Thrombolysis 14:179-96. 2002
    ..Adjunctive percutaneous and other treatments are also discussed, to clarify what is becoming a rapidly changing field...
  95. ncbi request reprint Evaluation by optical coherence tomography of neointimal coverage of sirolimus-eluting stent three months after implantation
    Masamichi Takano
    Department of Internal Medicine, Chiba Hokusoh Hospital, Nippon Medical School, Chiba, Japan
    Am J Cardiol 99:1033-8. 2007
    ..005, respectively). In conclusion, neointimal coverage over a SES at 3-month follow-up is incomplete in ACS and non-ACS. Our study suggests that dual antiplatelet therapy might be continued >3 months after SES implantation...
  96. ncbi request reprint From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part I
    Morteza Naghavi
    The Center for Vulnerable Plaque Research, University of Texas Houston, The Texas Heart Institute, and President Bush Center for Cardiovascular Health, Memorial Hermann Hospital, Houston, USA
    Circulation 108:1664-72. 2003
    ..We encourage healthcare policy makers to promote translational research for screening and treatment of vulnerable patients...
  97. ncbi request reprint Relationship between degree of remodeling and CT attenuation of plaque in coronary atherosclerotic lesions: an in-vivo analysis by multi-detector computed tomography
    Michael Schmid
    Department of Internal Medicine 2 Cardiology, University of Erlangen, Erlangen, Germany
    Atherosclerosis 197:457-64. 2008
    ..We thus evaluated the relationship between remodeling and CT attenuation of coronary atherosclerotic plaque by MDCT...
  98. ncbi request reprint Characterization of non-calcified coronary atherosclerotic plaque by multi-detector row CT: comparison to IVUS
    Karsten Pohle
    Department of Internal Medicine, University of Erlangen, Erlangen, Germany
    Atherosclerosis 190:174-80. 2007
    ..We investigated the CT attenuation of non-calcified plaques as determined by 16-slice MDCT in comparison to intravascular ultrasound (IVUS)...
  99. ncbi request reprint Effect of thrombocytopenia on outcomes following treatment with either enoxaparin or unfractionated heparin in patients presenting with acute coronary syndromes
    Robert W Yeh
    Department of Medicine, University of California, San Francisco, San Francisco, California, USA
    Am J Cardiol 100:1734-8. 2007
    ..In conclusion, thrombocytopenia is a significant correlate of adverse events in patients presenting with non-ST-elevation ACS treated with either enoxaparin or UFH...
  100. ncbi request reprint Effect of body mass index on Argatroban therapy during percutaneous coronary intervention
    Marcie J Hursting
    Clinical Science Consulting, Austin, TX, USA
    J Thromb Thrombolysis 25:273-9. 2008
    ..We investigated the effect of body mass index (BMI), and specifically obesity (BMI>30 kg/m2), on argatroban therapy during PCI...
  101. ncbi request reprint Neointimal proliferation around malapposed struts of a sirolimus-eluting stent: optical coherence tomography findings
    Masamichi Takano
    Department of Internal Medicine, Chiba Hokusoh Hospital, Nippon Medical School, IMBA, Chiba 270 1694, Japan
    Eur Heart J 27:1763. 2006