Michael Jaklitsch

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc Prospective phase II trial of preresection thoracoscopic mediastinal restaging after neoadjuvant therapy for IIIA (N2) non-small cell lung cancer: results of CALGB Protocol 39803
    Michael T Jaklitsch
    Division of Thoracic Surgery, Brigham and Women s Hospital, Boston, Mass 02115, USA
    J Thorac Cardiovasc Surg 146:9-16. 2013
  2. doi request reprint The American Association for Thoracic Surgery guidelines for lung cancer screening using low-dose computed tomography scans for lung cancer survivors and other high-risk groups
    Michael T Jaklitsch
    Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Thorac Cardiovasc Surg 144:33-8. 2012
  3. ncbi request reprint Open-lung biopsy guides therapy in children
    M T Jaklitsch
    Department of Surgery, University of Minnesota, Minneapolis 55455, USA
    Ann Thorac Surg 71:1779-85. 2001
  4. ncbi request reprint The use of surgery to treat lung cancer in elderly patients
    Michael T Jaklitsch
    Division of Thoracic Surgery, Brigham and Women s Hospital, MA 02115, USA
    Lancet Oncol 4:463-71. 2003
  5. ncbi request reprint Nodal downstaging predicts survival following induction chemotherapy for stage IIIA (N2) non-small cell lung cancer in CALGB protocol #8935
    Michael T Jaklitsch
    Division of Thoracic Surgery, Brigham and Women s Hospital, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    J Surg Oncol 94:599-606. 2006
  6. ncbi request reprint Thoracoscopic surgery in elderly lung cancer patients
    Michael T Jaklitsch
    Division of Thoracic Surgery, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Crit Rev Oncol Hematol 49:165-71. 2004
  7. doi request reprint Preoperative evaluation and risk assessment for elderly thoracic surgery patients
    Michael Jaklitsch
    Division of Thoracic Surgery, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Thorac Surg Clin 19:301-12. 2009
  8. ncbi request reprint Vaccination with irradiated, autologous melanoma cells engineered to secrete granulocyte-macrophage colony-stimulating factor by adenoviral-mediated gene transfer augments antitumor immunity in patients with metastatic melanoma
    Robert Soiffer
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, USA
    J Clin Oncol 21:3343-50. 2003
  9. ncbi request reprint Vaccination with irradiated autologous tumor cells engineered to secrete granulocyte-macrophage colony-stimulating factor augments antitumor immunity in some patients with metastatic non-small-cell lung carcinoma
    Ravi Salgia
    Department of Adult Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02215, USA
    J Clin Oncol 21:624-30. 2003
  10. pmc Smoking cessation is challenging even for patients recovering from lung cancer surgery with curative intent
    Mary E Cooley
    Dana Farber Cancer Institute, Phyllis F Cantor Center, Research in Nursing and Patient Care, Boston, MA, USA mary
    Lung Cancer 66:218-25. 2009

Detail Information

Publications47

  1. pmc Prospective phase II trial of preresection thoracoscopic mediastinal restaging after neoadjuvant therapy for IIIA (N2) non-small cell lung cancer: results of CALGB Protocol 39803
    Michael T Jaklitsch
    Division of Thoracic Surgery, Brigham and Women s Hospital, Boston, Mass 02115, USA
    J Thorac Cardiovasc Surg 146:9-16. 2013
    ..Accurate pathologic restaging of N2 stations after neoadjuvant therapy in stage IIIA (N2) non-small cell lung cancer is needed...
  2. doi request reprint The American Association for Thoracic Surgery guidelines for lung cancer screening using low-dose computed tomography scans for lung cancer survivors and other high-risk groups
    Michael T Jaklitsch
    Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Thorac Cardiovasc Surg 144:33-8. 2012
    ..Lung cancer is the leading cause of cancer death in North America. Low-dose computed tomography screening can reduce lung cancer-specific mortality by 20%...
  3. ncbi request reprint Open-lung biopsy guides therapy in children
    M T Jaklitsch
    Department of Surgery, University of Minnesota, Minneapolis 55455, USA
    Ann Thorac Surg 71:1779-85. 2001
    ..Open-lung biopsy is uncommon in children. Modern indications and outcomes are unknown...
  4. ncbi request reprint The use of surgery to treat lung cancer in elderly patients
    Michael T Jaklitsch
    Division of Thoracic Surgery, Brigham and Women s Hospital, MA 02115, USA
    Lancet Oncol 4:463-71. 2003
    ..Every effort should be made to assess risk and optimise treatment for this large and expanding proportion of the population...
  5. ncbi request reprint Nodal downstaging predicts survival following induction chemotherapy for stage IIIA (N2) non-small cell lung cancer in CALGB protocol #8935
    Michael T Jaklitsch
    Division of Thoracic Surgery, Brigham and Women s Hospital, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    J Surg Oncol 94:599-606. 2006
    ..Induction cisplatin/vinblastine chemotherapy was followed by surgical resection, adjuvant cisplatin/vinblastine, and radiotherapy. We now evaluate the prognosis of pathologic nodes...
  6. ncbi request reprint Thoracoscopic surgery in elderly lung cancer patients
    Michael T Jaklitsch
    Division of Thoracic Surgery, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Crit Rev Oncol Hematol 49:165-71. 2004
    ..Proposed investigations of the psychosocial implications of thoracic surgery in the elderly, irrespective of the safety of these maneuvers, are addressed...
  7. doi request reprint Preoperative evaluation and risk assessment for elderly thoracic surgery patients
    Michael Jaklitsch
    Division of Thoracic Surgery, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Thorac Surg Clin 19:301-12. 2009
    ..Careful selection of patients for surgery has contributed to the improvement in operative mortality over time, and refinements in preoperative testing should continue this trend in the future...
  8. ncbi request reprint Vaccination with irradiated, autologous melanoma cells engineered to secrete granulocyte-macrophage colony-stimulating factor by adenoviral-mediated gene transfer augments antitumor immunity in patients with metastatic melanoma
    Robert Soiffer
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, USA
    J Clin Oncol 21:3343-50. 2003
    ..We conducted a phase I clinical trial testing the biologic activity of vaccination with irradiated, autologous melanoma cells engineered to secrete GM-CSF by adenoviral-mediated gene transfer...
  9. ncbi request reprint Vaccination with irradiated autologous tumor cells engineered to secrete granulocyte-macrophage colony-stimulating factor augments antitumor immunity in some patients with metastatic non-small-cell lung carcinoma
    Ravi Salgia
    Department of Adult Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02215, USA
    J Clin Oncol 21:624-30. 2003
    ..To test whether this vaccination strategy enhances antitumor immunity in patients with metastatic non-small-cell lung cancer (NSCLC), we conducted a phase I clinical trial...
  10. pmc Smoking cessation is challenging even for patients recovering from lung cancer surgery with curative intent
    Mary E Cooley
    Dana Farber Cancer Institute, Phyllis F Cantor Center, Research in Nursing and Patient Care, Boston, MA, USA mary
    Lung Cancer 66:218-25. 2009
    ..The goals of this study were to determine: (1) patterns of smoking during post-operative recovery, (2) types of cessation strategies used to quit smoking, and (3) factors related to smoking after lung cancer surgery...
  11. ncbi request reprint Prostate biopsy: past, present, and future
    Joseph P Silletti
    Department of Urology, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Urology 69:413-6. 2007
  12. ncbi request reprint A prognostic test for adenocarcinoma of the lung from gene expression profiling data
    Gavin J Gordon
    Division of Thoracic Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 12:905-10. 2003
    ..Our results provide additional evidence that expression ratios are highly accurate in predicting cancer recurrence and may be used in a simple test to predict response to surgical therapy in early-stage lung adenocarcinoma...
  13. ncbi request reprint Similar long-term survival of elderly patients with non-small cell lung cancer treated with lobectomy or wedge resection within the surveillance, epidemiology, and end results database
    Carlos M Mery
    Division of Thoracic Surgery, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Chest 128:237-45. 2005
    ..To determine the effect of age and type of surgery on long-term survival in patients with early-stage non-small cell lung cancer (NSCLC)...
  14. ncbi request reprint Diameter of non-small cell lung cancer correlates with long-term survival: implications for T stage
    Carlos M Mery
    Division of Thoracic Surgery and Department of Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Chest 128:3255-60. 2005
    ..To determine the effect of tumor diameter on the long-term survival of patients with stage I non-small cell lung cancer (NSCLC) within a large multi-institutional database, and to assess the accuracy of the T-descriptor threshold of 3 cm...
  15. ncbi request reprint Laparoscopic fundoplication in patients with end-stage lung disease awaiting transplantation
    Philip A Linden
    Division of Thoracic Surgery, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass 02115, USA
    J Thorac Cardiovasc Surg 131:438-46. 2006
    ..We evaluated the risk and physiologic effect of laparoscopic fundoplication in patients on the lung transplant waiting list...
  16. ncbi request reprint Effectiveness of trichostatin A as a potential candidate for anticancer therapy in non-small-cell lung cancer
    Nishit K Mukhopadhyay
    Division of Thoracic Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Ann Thorac Surg 81:1034-42. 2006
    ....
  17. ncbi request reprint Phase I to II study of pleurectomy/decortication and intraoperative intracavitary hyperthermic cisplatin lavage for mesothelioma
    William G Richards
    Brigham and Women s Hospital, Boston, MA 02115, USA
    J Clin Oncol 24:1561-7. 2006
    ..To evaluate morbidity, mortality, maximum-tolerated dose (MTD), and outcome of intraoperative intracavitary hyperthermic cisplatin lavage in patients undergoing pleurectomy for malignant pleural mesothelioma (MPM)...
  18. ncbi request reprint Morbidity of lung resection after prior lobectomy: results from the Veterans Affairs National Surgical Quality Improvement Program
    Philip A Linden
    Division of Thoracic Surgery, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Ann Thorac Surg 83:425-31; discussion 432. 2007
    ..The risks of repeat lung resection have not been well quantified or analyzed. We used a national, prospectively recorded database to evaluate the complication rate and risk factors in this population...
  19. ncbi request reprint Modified T-tube repair of delayed esophageal perforation results in a low mortality rate similar to that seen with acute perforations
    Philip A Linden
    Division of Thoracic Surgery, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Ann Thorac Surg 83:1129-33. 2007
    ..We present a large series of patients requiring operative treatment of esophageal perforations with attention to an infrequently used method of dealing with delayed intrathoracic perforations...
  20. ncbi request reprint Factors predicting poor survival after resection of stage IA non-small cell lung cancer
    Michael Y Chang
    Division of Thoracic Surgery, Brigham and Women s Hospital, Harvard Medical School, and Boston VA Healthcare, Harvard School of Public Health, Boston, Mass, USA
    J Thorac Cardiovasc Surg 134:850-6. 2007
    ..Using a national cancer registry, we determined the postoperative survival of patients with stage IA non-small cell lung cancer in the United States from 1988 to 1997 and identified factors that affect survival...
  21. doi request reprint Extending indications for radiofrequency ablation of lung tumors through an intraoperative approach
    Philip A Linden
    Division of Thoracic and Esophageal Surgery, Case Medical Center and Case Western Reserve School of Medicine, Cleveland, Ohio 44106, USA
    Ann Thorac Surg 85:420-3. 2008
    ..We detail instances of RFA in patients who were either not candidates for percutaneous RFA or in whom the tumor was found to be unresectable at operation...
  22. ncbi request reprint Respiratory impedance following bronchoscopic or surgical lung volume reduction for emphysema
    Edward P Ingenito
    Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Respiration 72:406-17. 2005
    ..Understanding the differential effects of surgical volume reduction therapy (LVRS) and BLVR on lung and chest wall physiology will assist physicians in selecting an optimal approach for patients...
  23. doi request reprint Complications of extrapleural pneumonectomy
    Lambros Zellos
    Department of Thoracic Surgery, Brigham and Women s Hospital, Boston, MA 02115, USA
    Semin Thorac Cardiovasc Surg 19:355-9. 2007
    ..We have drawn upon our single-institution experience to describe the most common source of morbidity following EPP and to offer successful interventions...
  24. ncbi request reprint Inhibitor of apoptosis protein-1 promotes tumor cell survival in mesothelioma
    Gavin J Gordon
    Division of Thoracic Surgery, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Carcinogenesis 23:1017-24. 2002
    ..Our observations strongly suggest that IAP-1 is at least partly responsible for promoting carcinogenesis and mediating resistance to cisplatin in many MPM tumors and that further study of this apoptotic pathway is warranted...
  25. ncbi request reprint Gastropericardial fistula after laparoscopic surgery for reflux disease
    Sudish Murthy
    Department of Cardiothoracic Surgery, Cleveland Clinic Foundation, Cleveland, USA
    N Engl J Med 346:328-32. 2002
  26. ncbi request reprint Activation of focal adhesion kinase in human lung cancer cells involves multiple and potentially parallel signaling events
    Nishit K Mukhopadhyay
    Division of Thoracic Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, 02115, USA
    J Cell Mol Med 9:387-97. 2005
    ..Collectively, this report defines the existence of multiple and potentially parallel Coll IV/beta1-integrin mediated signaling events in Calu-1 cells, which involve FAK, ERKs, and PKC...
  27. ncbi request reprint Lung resection in patients with preoperative FEV1 < 35% predicted
    Philip A Linden
    Division of Thoracic Surgery, Brigham and Women s Hospital and Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
    Chest 127:1984-90. 2005
    ..To determine the morbidity, mortality, and feasibility of lung resection in patients with tumors and preoperative FEV1 < 35% predicted...
  28. ncbi request reprint Endoscopic management of hypopharyngeal stenosis after organ sparing therapy for head and neck cancer
    Christopher A Sullivan
    Division of Otolaryngology, Head and Neck Surgery, Brigham and Women s Hospital, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Laryngoscope 114:1924-31. 2004
    ..The objective of this study was to describe and evaluate the efficacy of an endoscopic technique for the management of postchemoradiation hypopharyngeal stenosis in head and neck cancer patients...
  29. ncbi request reprint Prevention, early detection, and management of complications after 328 consecutive extrapleural pneumonectomies
    David J Sugarbaker
    Division of Thoracic Surgery, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Thorac Cardiovasc Surg 128:138-46. 2004
    ..Complications after extrapleural pneumonectomy were further analyzed to elucidate means of prevention, early detection, and treatment...
  30. ncbi request reprint Pleural biopsy: a reliable method for determining the diagnosis but not subtype in mesothelioma
    Raphael Bueno
    Division of Thoracic Surgery, Brigham and Women s Hospital, Boston, MA 02115, USA
    Ann Thorac Surg 78:1774-6. 2004
    ..Pleural biopsy has been proposed as the diagnostic gold standard. We investigated the accuracy of open pleural biopsy for diagnosis and subtype identification in MPM...
  31. ncbi request reprint Malignant pleural mesothelioma: overview of the North American and European experience
    Jasleen Kukreja
    Division of Thoracic Surgery, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Thorac Surg Clin 14:435-45. 2004
    ....
  32. ncbi request reprint Relationship between a history of antecedent cancer and the probability of malignancy for a solitary pulmonary nodule
    Carlos M Mery
    Division of Thoracic Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Chest 125:2175-81. 2004
    ..To determine the probability of malignancy for a solitary pulmonary nodule (SPN) as a function of cancer history...
  33. ncbi request reprint Preoperative assessment and therapeutic options for patients with malignant pleural mesothelioma
    Subroto Paul
    Division of Thoracic Surgery, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Thorac Surg Clin 14:505-16, ix. 2004
    ..Heightened clinical suspicion and proper patient selection through accurate staging and pathologic identification are paramount to defining and delivering therapy for this rare, lethal cancer...
  34. ncbi request reprint Using gene expression ratios to predict outcome among patients with mesothelioma
    Gavin J Gordon
    Division of Thoracic Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Natl Cancer Inst 95:598-605. 2003
    ..We examined whether this technique could predict treatment-related outcome for patients with mesothelioma...
  35. ncbi request reprint Endovascular stent-graft repair of a pulmonary artery-bronchial fistula
    Brian D Davison
    Department of Radiology, Brigham and Women s Hospital, 75 Francis Street, Boston, Massachusetts 02115, USA
    J Vasc Interv Radiol 14:929-32. 2003
    ..The patient was successfully treated with endovascular placement of a covered stent...
  36. ncbi request reprint Menopausal effects on presentation, treatment, and survival of women with non-small cell lung cancer
    Kimberly A Moore
    Division of Thoracic Surgery, Department of General Surgery, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Ann Thorac Surg 76:1789-95. 2003
    ..Because human NSCLC cells express estrogen receptors, we evaluated hormonally active and inactive women to identify biologically mediated differences...
  37. ncbi request reprint High risk of brain metastases in surgically staged IIIA non-small-cell lung cancer patients treated with surgery, chemotherapy, and radiation
    Harvey J Mamon
    Department of Radiation Oncology and Medical Oncology, Dana Farber Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    J Clin Oncol 23:1530-7. 2005
    ..We sought to review our experience with surgically staged IIIA (N2) non-small-cell lung cancer (NSCLC), focusing on the patterns of failure in consecutively treated patients from 1988 to 2000...
  38. ncbi request reprint Integrin-dependent protein tyrosine phosphorylation is a key regulatory event in collagen-IV-mediated adhesion and proliferation of human lung tumor cell line, Calu-1
    Nishit K Mukhopadhyay
    Division of Thoracic Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Ann Thorac Surg 78:450-7. 2004
    ..During invasion, tumor cells attach to the basement membrane protein, collagen type IV, degrade it, migrate through blood vessels, and adhere to extracellular matrix proteins...
  39. ncbi request reprint Detection and quantification of SV40 large T-antigen DNA in mesothelioma tissues and cell lines
    Gavin J Gordon
    Division of Thoracic Surgery, Brigham and Women s Hospital, Boston, MA 02115, USA
    Oncol Rep 9:631-4. 2002
    ..In addition, SV40 sequences were found in 2/35 tissues and 3/7 cell lines in relatively low abundance. We conclude that SV40 is not a contributing factor in the pathobiology of the majority of MPM tumors from patients at our institution...
  40. pmc Immunologic and clinical effects of antibody blockade of cytotoxic T lymphocyte-associated antigen 4 in previously vaccinated cancer patients
    F Stephen Hodi
    Department of Medical Oncology and Cancer Vaccine Center, Dana Farber Cancer Institute, Brigham and Women s Hospital and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:3005-10. 2008
    ....
  41. ncbi request reprint Surgical management of oncogeriatric patients
    Riccardo A Audisio
    University of Liverpool, Liverpool, United Kingdom
    J Clin Oncol 25:1924-9. 2007
    ..These principally are occurring in improved anesthetic care, minimally invasive surgery, nonoperative therapies, risk assessment, and quality-of-life estimates...
  42. ncbi request reprint Unusual problems in breast cancer and a rare lung cancer case. Case 4. Primary lymphoepithelioma-like carcinoma of the lung
    Hanna Y Irie
    Dana Farber Cancer Institute, Brigham and Women s Hospital, Boston, MA, USA
    J Clin Oncol 21:2220-2. 2003
  43. ncbi request reprint Section IV: selective use of neoadjuvant therapy
    Jasleen Kukreja
    Division of Thoracic Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Semin Thorac Cardiovasc Surg 15:187-96. 2003
    ....
  44. ncbi request reprint Choices in the management of asymptomatic lung nodules in the elderly
    Daniel C Wiener
    Department of General Surgery, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
    Surg Oncol 13:239-48. 2004
    ..It is no longer reasonable to deny elderly patients the benefits of surgical intervention simply on the basis of age. Every effort should be made to assess risk and optimize treatment for this large and growing segment of the population...
  45. ncbi request reprint Radiofrequency ablation of thoracic lesions: part 1, experiments in the normal porcine thorax
    Paul R Morrison
    Department of Radiology, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    AJR Am J Roentgenol 184:375-80. 2005
    ..In advance of our own clinical application, we performed experimental percutaneous radiofrequency ablation in normal lung tissues in a large animal model using a U.S. Food and Drug Administration-approved device to assess its use...
  46. ncbi request reprint Radiofrequency ablation of thoracic lesions: part 2, initial clinical experience--technical and multidisciplinary considerations in 30 patients
    Eric vanSonnenberg
    Department of Radiology, Brigham and Women s Hospital, Boston, MA 02115, USA
    AJR Am J Roentgenol 184:381-90. 2005
    ....
  47. doi request reprint VATS pericardiotomy for patients with known malignancy and pericardial effusion: survival and prognosis of positive cytology and metastatic involvement of the pericardium: a case control study
    Siyamek Neragi-Miandoab
    Department of Surgery, Cardiothoracic Surgery, Boston University Medical Center, Boston, MA 02118, USA
    Int J Surg 6:110-4. 2008
    ..Pericardiotomy for cancer patients with effusion can alleviate symptoms, but with unclear effect on long term survival. Our experience with VATS technique has produced some long-term survivors...