Farouc Jaffer

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi request reprint Molecular imaging of myocardial infarction
    Farouc A Jaffer
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
    J Mol Cell Cardiol 41:921-33. 2006
  2. ncbi request reprint Cellular imaging of inflammation in atherosclerosis using magnetofluorescent nanomaterials
    Farouc A Jaffer
    Harvard Medical School, Charlestown, MA 02129, USA
    Mol Imaging 5:85-92. 2006
  3. ncbi request reprint Molecular imaging in the clinical arena
    Farouc A Jaffer
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown 02129, USA
    JAMA 293:855-62. 2005
  4. ncbi request reprint Optical visualization of cathepsin K activity in atherosclerosis with a novel, protease-activatable fluorescence sensor
    Farouc A Jaffer
    Center for Molecular Imaging Research, Massachusetts General Hospital, Boston, MA 02129, USA
    Circulation 115:2292-8. 2007
  5. ncbi request reprint Molecular imaging of factor XIIIa activity in thrombosis using a novel, near-infrared fluorescent contrast agent that covalently links to thrombi
    Farouc A Jaffer
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, USA
    Circulation 110:170-6. 2004
  6. ncbi request reprint Seeing within: molecular imaging of the cardiovascular system
    Farouc A Jaffer
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, Mass 02129, USA
    Circ Res 94:433-45. 2004
  7. ncbi request reprint In vivo imaging of thrombin activity in experimental thrombi with thrombin-sensitive near-infrared molecular probe
    Farouc A Jaffer
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown 02129, USA
    Arterioscler Thromb Vasc Biol 22:1929-35. 2002
  8. ncbi request reprint Molecular and cellular imaging of atherosclerosis: emerging applications
    Farouc A Jaffer
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Am Coll Cardiol 47:1328-38. 2006
  9. pmc Arterial and aortic valve calcification abolished by elastolytic cathepsin S deficiency in chronic renal disease
    Elena Aikawa
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, 149 13th St, Room 5420, Charlestown, MA 02129, USA
    Circulation 119:1785-94. 2009
  10. ncbi request reprint Osteogenesis associates with inflammation in early-stage atherosclerosis evaluated by molecular imaging in vivo
    Elena Aikawa
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, 149 13th St, Room 5420, Charlestown, MA 02129, USA
    Circulation 116:2841-50. 2007

Detail Information

Publications33

  1. ncbi request reprint Molecular imaging of myocardial infarction
    Farouc A Jaffer
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
    J Mol Cell Cardiol 41:921-33. 2006
    ....
  2. ncbi request reprint Cellular imaging of inflammation in atherosclerosis using magnetofluorescent nanomaterials
    Farouc A Jaffer
    Harvard Medical School, Charlestown, MA 02129, USA
    Mol Imaging 5:85-92. 2006
    ..To better understand their cellular targeting and imaging capabilities in atherosclerosis, we investigated prototypical dextran-coated near-infrared fluorescent MFNPs in the apolipoprotein E-deficient (apo E-/-) mouse model...
  3. ncbi request reprint Molecular imaging in the clinical arena
    Farouc A Jaffer
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown 02129, USA
    JAMA 293:855-62. 2005
    ..To specifically demonstrate the potential of molecular imaging, we highlight recent advances in clinical and preclinical molecular imaging of cancer and atherosclerosis...
  4. ncbi request reprint Optical visualization of cathepsin K activity in atherosclerosis with a novel, protease-activatable fluorescence sensor
    Farouc A Jaffer
    Center for Molecular Imaging Research, Massachusetts General Hospital, Boston, MA 02129, USA
    Circulation 115:2292-8. 2007
    ..To assess better the biology of CatK activity in vivo, we developed a novel near-infrared fluorescence (NIRF) probe for imaging of CatK and evaluated it in mouse and human atherosclerosis...
  5. ncbi request reprint Molecular imaging of factor XIIIa activity in thrombosis using a novel, near-infrared fluorescent contrast agent that covalently links to thrombi
    Farouc A Jaffer
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, USA
    Circulation 110:170-6. 2004
    ..In vivo imaging of FXIIIa activity could further elucidate the role of this molecule in thrombosis and other biological processes and aid in the clinical detection of acute thrombi...
  6. ncbi request reprint Seeing within: molecular imaging of the cardiovascular system
    Farouc A Jaffer
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, Mass 02129, USA
    Circ Res 94:433-45. 2004
    ....
  7. ncbi request reprint In vivo imaging of thrombin activity in experimental thrombi with thrombin-sensitive near-infrared molecular probe
    Farouc A Jaffer
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown 02129, USA
    Arterioscler Thromb Vasc Biol 22:1929-35. 2002
    ..In this study, we investigated the ability of a novel thrombin-activatable molecular probe to provide in vivo images of thrombin activity in experimental thrombi...
  8. ncbi request reprint Molecular and cellular imaging of atherosclerosis: emerging applications
    Farouc A Jaffer
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Am Coll Cardiol 47:1328-38. 2006
    ..We envision that several molecular imaging approaches will become important adjuncts to the clinical management of high-risk atherosclerosis...
  9. pmc Arterial and aortic valve calcification abolished by elastolytic cathepsin S deficiency in chronic renal disease
    Elena Aikawa
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, 149 13th St, Room 5420, Charlestown, MA 02129, USA
    Circulation 119:1785-94. 2009
    ..Here, we used genetically modified mice and molecular imaging to test the hypothesis in vivo that cathepsin S (catS), a potent elastolytic proteinase, accelerates calcification in atherosclerotic mice with CRD induced by 5/6 nephrectomy...
  10. ncbi request reprint Osteogenesis associates with inflammation in early-stage atherosclerosis evaluated by molecular imaging in vivo
    Elena Aikawa
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, 149 13th St, Room 5420, Charlestown, MA 02129, USA
    Circulation 116:2841-50. 2007
    ..Arterial calcification is associated with cardiovascular events; however, mechanisms of calcification in atherosclerosis remain obscure...
  11. pmc Pioglitazone suppresses inflammation in vivo in murine carotid atherosclerosis: novel detection by dual-target fluorescence molecular imaging
    Kiyuk Chang
    Cardiovascular Research Center and the Cardiology Division, Massachusetts General Hospital, Boston, Mass 02114, USA
    Arterioscler Thromb Vasc Biol 30:1933-9. 2010
    ..To investigate the effects of pioglitazone (PIO), a peroxisome proliferator-activated receptor γ agonist, on plaque matrix metalloproteinase (MMP) and macrophage (Mac) responses in vivo in a molecular imaging study...
  12. ncbi request reprint A novel near-infrared fluorescence sensor for detection of thrombin activation in blood
    Ching Hsuan Tung
    Center for Molecular Imaging Research, Massachusetts General Hospital, 149 13th Street, Room 5406, Charlestown, MA 02129, USA
    Chembiochem 3:207-11. 2002
    ..In addition to potentially furthering our understanding of thrombin regulation in vivo, the thrombin-activated near-infrared probe may have broad clinical application to the diagnosis of arterial and venous thrombosis...
  13. ncbi request reprint Multimodality molecular imaging identifies proteolytic and osteogenic activities in early aortic valve disease
    Elena Aikawa
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, Mass 02129, USA
    Circulation 115:377-86. 2007
    ..Visualizing early changes in valvular cell functions in vivo may predict the future risk and identify therapeutic targets for prevention of aortic valve stenosis...
  14. pmc Real-time catheter molecular sensing of inflammation in proteolytically active atherosclerosis
    Farouc A Jaffer
    MGH CMIR, 149 13th St, Room 5406, Boston, MA 02129, USA
    Circulation 118:1802-9. 2008
    ..To enable intravascular detection of inflammation in atherosclerosis, we developed a near-infrared fluorescence (NIRF) catheter-based strategy to sense cysteine protease activity during vascular catheterization...
  15. ncbi request reprint Molecular imaging of cardiovascular disease
    Farouc A Jaffer
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Circulation 116:1052-61. 2007
  16. pmc Optical and multimodality molecular imaging: insights into atherosclerosis
    Farouc A Jaffer
    Cardiovascular Research Center and Cardiology Division, Center for Molecular Imaging Research, Brigham and Women s Hospital, Boston, Mass, USA
    Arterioscler Thromb Vasc Biol 29:1017-24. 2009
    ..This review highlights particular molecular imaging strategies that possess strong potential for clinical translation...
  17. ncbi request reprint Noninvasive vascular cell adhesion molecule-1 imaging identifies inflammatory activation of cells in atherosclerosis
    Matthias Nahrendorf
    Center for Molecular Imaging Research, Massachusetts General Hospital, Boston, USA
    Circulation 114:1504-11. 2006
    ....
  18. pmc Multimodal nanoagents for the detection of intravascular thrombi
    Jason R McCarthy
    Center for Molecular Imaging Research, Harvard Medical School, Massachusetts General Hospital, 149 13th Street, Room 5406, Charlestown, Massachusetts 02129, USA
    Bioconjug Chem 20:1251-5. 2009
    ..As demonstrated by in vitro and in vivo studies, both nanoagents possess high affinities for thrombi, and enable mutimodal fluorescence and magnetic resonance imaging...
  19. ncbi request reprint Near-infrared fluorescent imaging of cerebral thrombi and blood-brain barrier disruption in a mouse model of cerebral venous sinus thrombosis
    Dong Eog Kim
    Department of Radiology, Center for Molecular Imaging Research corrected Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    J Cereb Blood Flow Metab 25:226-33. 2005
    ..This demonstrates the feasibility of simultaneous in vivo monitoring of thrombus and BBB permeability in an animal model of cerebral venous thrombosis...
  20. doi request reprint Advances in fluorescence imaging of the cardiovascular system
    Kiyuk Chang
    Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Mass, USA
    J Nucl Cardiol 15:417-28. 2008
  21. doi request reprint Transglutaminase activity in acute infarcts predicts healing outcome and left ventricular remodelling: implications for FXIII therapy and antithrombin use in myocardial infarction
    Matthias Nahrendorf
    Center for Molecular Imaging Research, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, Room 5406, Charlestown, MA 02129, USA
    Eur Heart J 29:445-54. 2008
    ..Here we assess the impact of transglutaminase-modulating therapies on healing and evolution of heart failure using a novel, non-invasive molecular imaging technique...
  22. pmc Intravascular near-infrared fluorescence molecular imaging of atherosclerosis: toward coronary arterial visualization of biologically high-risk plaques
    Marcella A Calfon
    Massachusetts General Hospital, Cardiovascular Research Center and Cardiology Division, Boston, Massachusetts 02114, USA
    J Biomed Opt 15:011107. 2010
    ....
  23. ncbi request reprint Novel factor XIII probes for blood coagulation imaging
    Ching Hsuan Tung
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Chembiochem 4:897-9. 2003
  24. ncbi request reprint Detection of macrophage activity in atherosclerosis in vivo using multichannel, high-resolution laser scanning fluorescence microscopy
    Ashvin N Pande
    Massachusetts General Hospital, Harvard Medical School, Center for Molecular Imaging Research, Charlestown, Massachusetts 02129, USA
    J Biomed Opt 11:021009. 2006
    ..86). The validated experimental methodology thus establishes a platform for investigating macrophage activity in atherosclerosis in vivo, and has implications for the detection of clinical vulnerable plaques...
  25. ncbi request reprint A branched fluorescent peptide probe for imaging of activated platelets
    Ching Hsuan Tung
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Mol Pharm 2:92-5. 2005
    ..2PF fluorescence was also found 5.5-fold higher than that of the control probe, 2CF. Overall, our results suggest that 2PF binds tightly to GP-IIb/IIIa and potentially can be used for in vivo imaging of thrombosis...
  26. pmc Advances in molecular imaging of atherosclerotic vascular disease
    Eric A Osborn
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02114, USA
    Curr Opin Cardiol 23:620-8. 2008
    ..Here we present recent exciting advances in molecular imaging of atherosclerotic vascular disease...
  27. doi request reprint Optical molecular imaging in atherosclerosis
    Sharath Subramanian
    Cardiac MR PET CT Program, Massachusetts General Hospital, 165 Cambridge Street, Suite 400, Boston, MA 02114, USA
    J Nucl Cardiol 17:135-44. 2010
    ..This review highlights the various optical imaging techniques and their application in assessing biological processes in atherosclerosis...
  28. pmc Monocyte accumulation in mouse atherogenesis is progressive and proportional to extent of disease
    Filip K Swirski
    Center for Molecular Imaging Research and Donald W Reynolds Cardiovascular Clinical Research Center on Atherosclerosis at Harvard Medical School, Massachusetts General Hospital and Harvard Medical School, CNY 149, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 103:10340-5. 2006
    ..These results provide insights into mechanisms of atherogenesis and have implications for the duration of therapies directed at leukocyte recruitment...
  29. ncbi request reprint A macrophage-targeted theranostic nanoparticle for biomedical applications
    Jason R McCarthy
    Center for Molecular Imaging Research, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, Room 5406, Charlestown, MA 02129, USA
    Small 2:983-7. 2006
  30. ncbi request reprint Images in cardiovascular medicine. Culprit lesion atherothrombectomy during acute myocardial infarction: extraction of an acute coronary plaque rupture
    Rodolfo Carrillo-Jimenez
    Cardiology Division, Department of Internal Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Circulation 112:e267. 2005
  31. ncbi request reprint Age and sex distribution of subclinical aortic atherosclerosis: a magnetic resonance imaging examination of the Framingham Heart Study
    Farouc A Jaffer
    Harvard Thorndike Laboratory of the Department of Medicine, Cardiovascular Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass 02215, USA
    Arterioscler Thromb Vasc Biol 22:849-54. 2002
    ..These noninvasive CMR data extend the prior autopsy-based prevalence estimates of subclinical atherosclerosis and may help to lay the foundation for future studies of risk stratification and treatment of affected individuals...
  32. ncbi request reprint Case records of the Massachusetts General Hospital. Case 34-2006. A 72-year-old woman with nausea followed by hypotension and respiratory failure
    Paula A Johnson
    Division of Women s Health, Brigham and Women s Hospital, Massachusetts General Hospital, Boston, USA
    N Engl J Med 355:2022-31. 2006
  33. pmc Factor XIII deficiency causes cardiac rupture, impairs wound healing, and aggravates cardiac remodeling in mice with myocardial infarction
    Matthias Nahrendorf
    Medizinische Klinik und Poliklinik I, Universitat Wurzburg, Wurzburg, Germany
    Circulation 113:1196-202. 2006
    ..We hypothesized that clotting factor XIII (FXIII), a transglutaminase involved in wound healing, may play an important role in MI given prior clinical and mouse model data...

Research Grants1

  1. Intravascular Fluorescence Molecular Imaging of Inflammation in Atherosclerosis
    Farouc Jaffer; Fiscal Year: 2010
    ..The results from this project could enable the development of clinical fluorescence imaging strategies to reduce heart attacks. ..