Research Topics
Species | Farouc JafferSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
Research Grants
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Detail Information
Publications
Molecular imaging of myocardial infarctionFarouc A Jaffer
Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
J Mol Cell Cardiol 41:921-33. 2006....- Cellular imaging of inflammation in atherosclerosis using magnetofluorescent nanomaterialsFarouc A Jaffer
Harvard Medical School, Charlestown, MA 02129, USA
Mol Imaging 5:85-92. 2006..To better understand their cellular targeting and imaging capabilities in atherosclerosis, we investigated prototypical dextran-coated near-infrared fluorescent MFNPs in the apolipoprotein E-deficient (apo E-/-) mouse model... - Molecular imaging in the clinical arenaFarouc A Jaffer
Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown 02129, USA
JAMA 293:855-62. 2005..To specifically demonstrate the potential of molecular imaging, we highlight recent advances in clinical and preclinical molecular imaging of cancer and atherosclerosis... - Optical visualization of cathepsin K activity in atherosclerosis with a novel, protease-activatable fluorescence sensorFarouc A Jaffer
Center for Molecular Imaging Research, Massachusetts General Hospital, Boston, MA 02129, USA
Circulation 115:2292-8. 2007..To assess better the biology of CatK activity in vivo, we developed a novel near-infrared fluorescence (NIRF) probe for imaging of CatK and evaluated it in mouse and human atherosclerosis... - Molecular imaging of factor XIIIa activity in thrombosis using a novel, near-infrared fluorescent contrast agent that covalently links to thrombiFarouc A Jaffer
Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, USA
Circulation 110:170-6. 2004..In vivo imaging of FXIIIa activity could further elucidate the role of this molecule in thrombosis and other biological processes and aid in the clinical detection of acute thrombi... - Seeing within: molecular imaging of the cardiovascular systemFarouc A Jaffer
Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, Mass 02129, USA
Circ Res 94:433-45. 2004.... - In vivo imaging of thrombin activity in experimental thrombi with thrombin-sensitive near-infrared molecular probeFarouc A Jaffer
Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown 02129, USA
Arterioscler Thromb Vasc Biol 22:1929-35. 2002..In this study, we investigated the ability of a novel thrombin-activatable molecular probe to provide in vivo images of thrombin activity in experimental thrombi... - Molecular and cellular imaging of atherosclerosis: emerging applicationsFarouc A Jaffer
Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
J Am Coll Cardiol 47:1328-38. 2006..We envision that several molecular imaging approaches will become important adjuncts to the clinical management of high-risk atherosclerosis... 
Arterial and aortic valve calcification abolished by elastolytic cathepsin S deficiency in chronic renal diseaseElena Aikawa
Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, 149 13th St, Room 5420, Charlestown, MA 02129, USA
Circulation 119:1785-94. 2009..Here, we used genetically modified mice and molecular imaging to test the hypothesis in vivo that cathepsin S (catS), a potent elastolytic proteinase, accelerates calcification in atherosclerotic mice with CRD induced by 5/6 nephrectomy...- Osteogenesis associates with inflammation in early-stage atherosclerosis evaluated by molecular imaging in vivoElena Aikawa
Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, 149 13th St, Room 5420, Charlestown, MA 02129, USA
Circulation 116:2841-50. 2007..Arterial calcification is associated with cardiovascular events; however, mechanisms of calcification in atherosclerosis remain obscure... - Pioglitazone suppresses inflammation in vivo in murine carotid atherosclerosis: novel detection by dual-target fluorescence molecular imagingKiyuk Chang
Cardiovascular Research Center and the Cardiology Division, Massachusetts General Hospital, Boston, Mass 02114, USA
Arterioscler Thromb Vasc Biol 30:1933-9. 2010..To investigate the effects of pioglitazone (PIO), a peroxisome proliferator-activated receptor γ agonist, on plaque matrix metalloproteinase (MMP) and macrophage (Mac) responses in vivo in a molecular imaging study... - A novel near-infrared fluorescence sensor for detection of thrombin activation in bloodChing Hsuan Tung
Center for Molecular Imaging Research, Massachusetts General Hospital, 149 13th Street, Room 5406, Charlestown, MA 02129, USA
Chembiochem 3:207-11. 2002..In addition to potentially furthering our understanding of thrombin regulation in vivo, the thrombin-activated near-infrared probe may have broad clinical application to the diagnosis of arterial and venous thrombosis... - Multimodality molecular imaging identifies proteolytic and osteogenic activities in early aortic valve diseaseElena Aikawa
Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, Mass 02129, USA
Circulation 115:377-86. 2007..Visualizing early changes in valvular cell functions in vivo may predict the future risk and identify therapeutic targets for prevention of aortic valve stenosis... - Real-time catheter molecular sensing of inflammation in proteolytically active atherosclerosisFarouc A Jaffer
MGH CMIR, 149 13th St, Room 5406, Boston, MA 02129, USA
Circulation 118:1802-9. 2008..To enable intravascular detection of inflammation in atherosclerosis, we developed a near-infrared fluorescence (NIRF) catheter-based strategy to sense cysteine protease activity during vascular catheterization... - Molecular imaging of cardiovascular diseaseFarouc A Jaffer
Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
Circulation 116:1052-61. 2007 - Optical and multimodality molecular imaging: insights into atherosclerosisFarouc A Jaffer
Cardiovascular Research Center and Cardiology Division, Center for Molecular Imaging Research, Brigham and Women s Hospital, Boston, Mass, USA
Arterioscler Thromb Vasc Biol 29:1017-24. 2009..This review highlights particular molecular imaging strategies that possess strong potential for clinical translation... - Noninvasive vascular cell adhesion molecule-1 imaging identifies inflammatory activation of cells in atherosclerosisMatthias Nahrendorf
Center for Molecular Imaging Research, Massachusetts General Hospital, Boston, USA
Circulation 114:1504-11. 2006..This clinically translatable agent could noninvasively detect inflammation in early, subclinical atherosclerosis... - Multimodal nanoagents for the detection of intravascular thrombiJason R McCarthy
Center for Molecular Imaging Research, Harvard Medical School, Massachusetts General Hospital, 149 13th Street, Room 5406, Charlestown, Massachusetts 02129, USA
Bioconjug Chem 20:1251-5. 2009..As demonstrated by in vitro and in vivo studies, both nanoagents possess high affinities for thrombi, and enable mutimodal fluorescence and magnetic resonance imaging... - Near-infrared fluorescent imaging of cerebral thrombi and blood-brain barrier disruption in a mouse model of cerebral venous sinus thrombosisDong-Eog Kim
Department of Radiology, Center for Molecular Imaging Research [corrected] Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
J Cereb Blood Flow Metab 25:226-33. 2005..This demonstrates the feasibility of simultaneous in vivo monitoring of thrombus and BBB permeability in an animal model of cerebral venous thrombosis... - Advances in fluorescence imaging of the cardiovascular systemKiyuk Chang
Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Mass, USA
J Nucl Cardiol 15:417-28. 2008 
Transglutaminase activity in acute infarcts predicts healing outcome and left ventricular remodelling: implications for FXIII therapy and antithrombin use in myocardial infarctionMatthias Nahrendorf
Center for Molecular Imaging Research, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, Room 5406, Charlestown, MA 02129, USA
Eur Heart J 29:445-54. 2008..Here we assess the impact of transglutaminase-modulating therapies on healing and evolution of heart failure using a novel, non-invasive molecular imaging technique...- Intravascular near-infrared fluorescence molecular imaging of atherosclerosis: toward coronary arterial visualization of biologically high-risk plaquesMarcella A Calfon
Massachusetts General Hospital, Cardiovascular Research Center and Cardiology Division, Boston, Massachusetts 02114, USA
J Biomed Opt 15:011107. 2010.... - Novel factor XIII probes for blood coagulation imagingChing-Hsuan Tung
Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
Chembiochem 4:897-9. 2003 - Detection of macrophage activity in atherosclerosis in vivo using multichannel, high-resolution laser scanning fluorescence microscopyAshvin N Pande
Massachusetts General Hospital, Harvard Medical School, Center for Molecular Imaging Research, Charlestown, Massachusetts 02129, USA
J Biomed Opt 11:021009. 2006..86). The validated experimental methodology thus establishes a platform for investigating macrophage activity in atherosclerosis in vivo, and has implications for the detection of clinical vulnerable plaques... - A branched fluorescent peptide probe for imaging of activated plateletsChing-Hsuan Tung
Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
Mol Pharm 2:92-5. 2005..2PF fluorescence was also found 5.5-fold higher than that of the control probe, 2CF. Overall, our results suggest that 2PF binds tightly to GP-IIb/IIIa and potentially can be used for in vivo imaging of thrombosis... - Advances in molecular imaging of atherosclerotic vascular diseaseEric A Osborn
Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02114, USA
Curr Opin Cardiol 23:620-8. 2008..Here we present recent exciting advances in molecular imaging of atherosclerotic vascular disease... - Optical molecular imaging in atherosclerosisSharath Subramanian
Cardiac MR PET CT Program, Massachusetts General Hospital, 165 Cambridge Street, Suite 400, Boston, MA 02114, USA
J Nucl Cardiol 17:135-44. 2010..This review highlights the various optical imaging techniques and their application in assessing biological processes in atherosclerosis... - Monocyte accumulation in mouse atherogenesis is progressive and proportional to extent of diseaseFilip K Swirski
Center for Molecular Imaging Research and Donald W. Reynolds Cardiovascular Clinical Research Center on Atherosclerosis at Harvard Medical School, Massachusetts General Hospital and Harvard Medical School, CNY 149, Charlestown, MA 02129, USA
Proc Natl Acad Sci U S A 103:10340-5. 2006..These results provide insights into mechanisms of atherogenesis and have implications for the duration of therapies directed at leukocyte recruitment... - A macrophage-targeted theranostic nanoparticle for biomedical applicationsJason R McCarthy
Center for Molecular Imaging Research, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, Room 5406, Charlestown, MA 02129, USA
Small 2:983-7. 2006 - Images in cardiovascular medicine. Culprit lesion atherothrombectomy during acute myocardial infarction: extraction of an acute coronary plaque ruptureRodolfo Carrillo-Jimenez
Cardiology Division, Department of Internal Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
Circulation 112:e267. 2005 - Age and sex distribution of subclinical aortic atherosclerosis: a magnetic resonance imaging examination of the Framingham Heart StudyFarouc A Jaffer
Harvard-Thorndike Laboratory of the Department of Medicine, Cardiovascular Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass 02215, USA
Arterioscler Thromb Vasc Biol 22:849-54. 2002..These noninvasive CMR data extend the prior autopsy-based prevalence estimates of subclinical atherosclerosis and may help to lay the foundation for future studies of risk stratification and treatment of affected individuals... - Case records of the Massachusetts General Hospital. Case 34-2006. A 72-year-old woman with nausea followed by hypotension and respiratory failurePaula A Johnson
Division of Women's Health, Brigham and Women's Hospital, Massachusetts General Hospital, Boston, USA
N Engl J Med 355:2022-31. 2006 - Factor XIII deficiency causes cardiac rupture, impairs wound healing, and aggravates cardiac remodeling in mice with myocardial infarctionMatthias Nahrendorf
Medizinische Klinik und Poliklinik I, Universitat Wurzburg, Wurzburg, Germany
Circulation 113:1196-202. 2006..We hypothesized that clotting factor XIII (FXIII), a transglutaminase involved in wound healing, may play an important role in MI given prior clinical and mouse model data...
Research Grants
- Intravascular Fluorescence Molecular Imaging of Inflammation in AtherosclerosisFarouc Jaffer; Fiscal Year: 2010..The results from this project could enable the development of clinical fluorescence imaging strategies to reduce heart attacks. ..