Karen R Jacobson

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc Implementation of genotype MTBDRplus reduces time to multidrug-resistant tuberculosis therapy initiation in South Africa
    Karen R Jacobson
    Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA 02114, USA
    Clin Infect Dis 56:503-8. 2013
  2. ncbi Treatment outcomes among patients with extensively drug-resistant tuberculosis: systematic review and meta-analysis
    Karen R Jacobson
    Division of Infectious Disease, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Clin Infect Dis 51:6-14. 2010
  3. pmc Treatment outcomes of isoniazid-resistant tuberculosis patients, Western Cape Province, South Africa
    Karen R Jacobson
    Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Clin Infect Dis 53:369-72. 2011
  4. pmc Genomic analysis identifies targets of convergent positive selection in drug-resistant Mycobacterium tuberculosis
    Maha R Farhat
    1 Pulmonary and Critical Care Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA 2
    Nat Genet 45:1183-9. 2013
  5. pmc Systematic review of allelic exchange experiments aimed at identifying mutations that confer drug resistance in Mycobacterium tuberculosis
    Hanna Nebenzahl-Guimaraes
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    J Antimicrob Chemother 69:331-42. 2014

Detail Information

Publications5

  1. pmc Implementation of genotype MTBDRplus reduces time to multidrug-resistant tuberculosis therapy initiation in South Africa
    Karen R Jacobson
    Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA 02114, USA
    Clin Infect Dis 56:503-8. 2013
    ..We sought to determine whether implementation of the rapid MTBDRplus diagnostic shortened the time from specimen collection to patient MDR tuberculosis therapy initiation...
  2. ncbi Treatment outcomes among patients with extensively drug-resistant tuberculosis: systematic review and meta-analysis
    Karen R Jacobson
    Division of Infectious Disease, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Clin Infect Dis 51:6-14. 2010
    ..We conducted a meta-analysis to assess XDR TB treatment outcomes and to identify therapeutic approaches associated with favorable responses...
  3. pmc Treatment outcomes of isoniazid-resistant tuberculosis patients, Western Cape Province, South Africa
    Karen R Jacobson
    Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Clin Infect Dis 53:369-72. 2011
    ..These data reveal the need for early identification and aggressive follow-up of isoniazid monoresistance to increase treatment success...
  4. pmc Genomic analysis identifies targets of convergent positive selection in drug-resistant Mycobacterium tuberculosis
    Maha R Farhat
    1 Pulmonary and Critical Care Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA 2
    Nat Genet 45:1183-9. 2013
    ..Functional genetic analysis of mutations in one gene, ponA1, demonstrated an in vitro growth advantage in the presence of the drug rifampicin...
  5. pmc Systematic review of allelic exchange experiments aimed at identifying mutations that confer drug resistance in Mycobacterium tuberculosis
    Hanna Nebenzahl-Guimaraes
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    J Antimicrob Chemother 69:331-42. 2014
    ..tuberculosis drug resistance are superior to associational studies in elucidating an individual mutation's contribution to the drug resistance phenotype...