Elliot Israel

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi request reprint Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trial
    Elliot Israel
    Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Lancet 364:1505-12. 2004
  2. pmc Combination therapy with a long-acting beta-agonist and a leukotriene antagonist in moderate asthma
    Aaron Deykin
    Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 175:228-34. 2007
  3. pmc Effect of beta2-adrenergic receptor polymorphism on response to longacting beta2 agonist in asthma (LARGE trial): a genotype-stratified, randomised, placebo-controlled, crossover trial
    Michael E Wechsler
    Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Lancet 374:1754-64. 2009
  4. pmc beta-Adrenergic receptor polymorphisms and response to salmeterol
    Michael E Wechsler
    Brigham and Women s Hospital, 75 Francis Street, Boston, MA, 02115, USA
    Am J Respir Crit Care Med 173:519-26. 2006
  5. pmc Exhaled breath condensate eicosanoid levels associate with asthma and its severity
    Shamsah Kazani
    Pulmonary and Critical Care Division, Department of Internal Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    J Allergy Clin Immunol 132:547-53. 2013
  6. pmc Impact of race on asthma treatment failures in the asthma clinical research network
    Michael E Wechsler
    Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Respir Crit Care Med 184:1247-53. 2011
  7. ncbi request reprint Sputum eosinophil counts predict asthma control after discontinuation of inhaled corticosteroids
    Aaron Deykin
    Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    J Allergy Clin Immunol 115:720-7. 2005
  8. pmc ITGB5 and AGFG1 variants are associated with severity of airway responsiveness
    Blanca E Himes
    Channing Division of Network Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    BMC Med Genet 14:86. 2013
  9. ncbi request reprint Genetics and the variability of treatment response in asthma
    Elliot Israel
    Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
    J Allergy Clin Immunol 115:S532-8. 2005
  10. pmc Cysteinyl leukotriene antagonism inhibits bronchoconstriction in response to hypertonic saline inhalation in asthma
    Shamsah Kazani
    Pulmonary and Critical Care Division, Department of Medicine, Brigham and Women s Hospital, PBB Clinics 3, 75 Francis Street, Boston, MA 02115, USA
    Respir Med 105:667-73. 2011

Detail Information

Publications46

  1. ncbi request reprint Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trial
    Elliot Israel
    Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Lancet 364:1505-12. 2004
    ..However, the existence of any genotype-dependent difference has not been tested in a prospective clinical trial...
  2. pmc Combination therapy with a long-acting beta-agonist and a leukotriene antagonist in moderate asthma
    Aaron Deykin
    Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 175:228-34. 2007
    ..The elements of asthma control achieved by LABAs (improved lung function) and leukotriene receptor antagonists (LTRAs; protection against exacerbations) may be complementary as well...
  3. pmc Effect of beta2-adrenergic receptor polymorphism on response to longacting beta2 agonist in asthma (LARGE trial): a genotype-stratified, randomised, placebo-controlled, crossover trial
    Michael E Wechsler
    Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Lancet 374:1754-64. 2009
    ..We investigated whether there is a genotype-specific response to treatment with a longacting beta2 agonist in combination with inhaled corticosteroid...
  4. pmc beta-Adrenergic receptor polymorphisms and response to salmeterol
    Michael E Wechsler
    Brigham and Women s Hospital, 75 Francis Street, Boston, MA, 02115, USA
    Am J Respir Crit Care Med 173:519-26. 2006
    ..Several studies suggest that patients with asthma who are homozygous for arginine at the 16th position of the beta2-adrenergic receptor may not benefit from short-acting beta-agonists...
  5. pmc Exhaled breath condensate eicosanoid levels associate with asthma and its severity
    Shamsah Kazani
    Pulmonary and Critical Care Division, Department of Internal Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    J Allergy Clin Immunol 132:547-53. 2013
    ..The relationship between anti-inflammatory lipoxins and proinflammatory leukotrienes might be important in the pathobiology and severity of asthma...
  6. pmc Impact of race on asthma treatment failures in the asthma clinical research network
    Michael E Wechsler
    Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Respir Crit Care Med 184:1247-53. 2011
    ..Recent studies suggest that people with asthma of different racial backgrounds may respond differently to various therapies...
  7. ncbi request reprint Sputum eosinophil counts predict asthma control after discontinuation of inhaled corticosteroids
    Aaron Deykin
    Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    J Allergy Clin Immunol 115:720-7. 2005
    ..Although inhaled corticosteroids (ICSs) are effective in preventing deterioration in asthma control, at least half of subjects with mild-to-moderate asthma will remain stable when these agents are discontinued...
  8. pmc ITGB5 and AGFG1 variants are associated with severity of airway responsiveness
    Blanca E Himes
    Channing Division of Network Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    BMC Med Genet 14:86. 2013
    ..We sought to determine whether common genetic variants were associated with AHR severity...
  9. ncbi request reprint Genetics and the variability of treatment response in asthma
    Elliot Israel
    Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
    J Allergy Clin Immunol 115:S532-8. 2005
    ....
  10. pmc Cysteinyl leukotriene antagonism inhibits bronchoconstriction in response to hypertonic saline inhalation in asthma
    Shamsah Kazani
    Pulmonary and Critical Care Division, Department of Medicine, Brigham and Women s Hospital, PBB Clinics 3, 75 Francis Street, Boston, MA 02115, USA
    Respir Med 105:667-73. 2011
    ..Whether polymorphisms in the leukotriene biosynthetic pathway affect the contribution of CysLTs to this response is also unknown...
  11. pmc Active albuterol or placebo, sham acupuncture, or no intervention in asthma
    Michael E Wechsler
    Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    N Engl J Med 365:119-26. 2011
    ..We compared the effects of a bronchodilator, two placebo interventions, and no intervention on outcomes in patients with asthma...
  12. ncbi request reprint How pharmacogenomics will play a role in the management of asthma
    Michael E Wechsler
    Pulmonary and Critical Care Division, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Am J Respir Crit Care Med 172:12-8. 2005
  13. pmc Genome-wide association identifies the T gene as a novel asthma pharmacogenetic locus
    Kelan G Tantisira
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Am J Respir Crit Care Med 185:1286-91. 2012
    ..To date, most studies aimed at discovering genetic factors influencing treatment response in asthma have focused on biologic candidate genes. Genome-wide association studies (GWAS) can rapidly identify novel pharmacogenetic loci...
  14. pmc Airway lipoxin A4 generation and lipoxin A4 receptor expression are decreased in severe asthma
    Anna Planagumà
    Pulmonary and Critical Care Medicine Division, Department of Internal Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Am J Respir Crit Care Med 178:574-82. 2008
    ..Airway inflammation is common in severe asthma despite antiinflammatory therapy with corticosteroids. Lipoxin A(4) (LXA(4)) is an arachidonic acid-derived mediator that serves as an agonist for resolution of inflammation...
  15. pmc Lipoxin A4 regulates natural killer cell and type 2 innate lymphoid cell activation in asthma
    Cindy Barnig
    Pulmonary and Critical Care Medicine Division, Department of Internal Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Sci Transl Med 5:174ra26. 2013
    ..Because lipoxin A4 generation is decreased in severe asthma, these findings also implicate unrestrained ILC activation in asthma pathobiology...
  16. pmc Diminished lipoxin biosynthesis in severe asthma
    Bruce D Levy
    Pulmonary and Critical Care Medicine and Partners Asthma Center, Department of Internal Medicine, PBB Clinics 3, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Am J Respir Crit Care Med 172:824-30. 2005
    ..Although arachidonic acid metabolism is well appreciated to regulate airway inflammation and reactivity, alterations in the biosynthetic capacity for both pro- and antiinflammatory eicosanoids in severe asthma have not been determined...
  17. ncbi request reprint The combined effects of zafirlukast, prednisone, and inhaled budesonide on IL-13 and IFN-gamma secretion
    Fiona K Gibbons
    Pulmonary and Critical Care Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, 02114, USA
    J Clin Immunol 25:437-44. 2005
    ..018) and allergen-specific lymphocyte proliferation (p = 0.02), while IL-13 secretion was unchanged (p = 0.109). This study indicates a role for Th1 cytokines as well as Th2 cytokines in the allergic response...
  18. pmc The role of pharmacogenomics in improving the management of asthma
    Shamsah Kazani
    Pulmonary and Critical Care Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Allergy Clin Immunol 125:295-302; quiz 303-4. 2010
    ..We explore the data developed from the early pharmacogenomic studies with the most common asthma therapies. Furthermore, we explore the potential use of pharmacogenomics, as well as caveats in interpreting such information...
  19. doi request reprint Mepolizumab as a steroid-sparing treatment option in patients with Churg-Strauss syndrome
    Sophia Kim
    Department of Pediatrics, Children s Hospital Boston, Boston, Mass, USA
    J Allergy Clin Immunol 125:1336-43. 2010
    ..Levels of IL-5, a cytokine regulating eosinophils, can be increased in patients with CSS. Mepolizumab, a humanized monoclonal anti-IL-5 antibody, decreases steroid requirements in patients with non-CSS hypereosinophilic syndromes...
  20. pmc Adam8 limits the development of allergic airway inflammation in mice
    Martin D Knolle
    Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 190:6434-49. 2013
    ..Thus, ADAM8 has anti-inflammatory activities during AAI in mice by activating the intrinsic apoptosis pathway in myeloid leukocytes. Strategies that increase ADAM8 levels in myeloid leukocytes may have therapeutic efficacy in asthma...
  21. doi request reprint Exhaled breath condensates in asthma: diagnostic and therapeutic implications
    Shamsah Kazani
    Pulmonary and Critical Care Division, PBB Clinics 3, 75 Francis Street, Boston, MA 02115, USA
    J Breath Res 4:047001. 2010
    ....
  22. pmc Protectin D1 is generated in asthma and dampens airway inflammation and hyperresponsiveness
    Bruce D Levy
    Pulmonary and Critical Care Medicine, Department of Internal Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 178:496-502. 2007
    ..Together, these findings provide evidence for endogenous PD1 as a pivotal counterregulatory signal in allergic airway inflammation and point to new therapeutic strategies for modulating inflammation in asthmatic lung...
  23. pmc Integration of mouse and human genome-wide association data identifies KCNIP4 as an asthma gene
    Blanca E Himes
    Channing Division of Network Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 8:e56179. 2013
    ..Our results suggest that a useful approach to identify genes associated with human asthma is to leverage mouse AHR association data...
  24. pmc Genome-wide association analysis in asthma subjects identifies SPATS2L as a novel bronchodilator response gene
    Blanca E Himes
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Genet 8:e1002824. 2012
    ....
  25. ncbi request reprint Effects of montelukast and beclomethasone on airway function and asthma control
    Elliot Israel
    Brigham and Women s Hospital, Boston, MA 02115, USA
    J Allergy Clin Immunol 110:847-54. 2002
    ..Maintaining asthma control is a major objective of therapy. Traditionally, the effectiveness of asthma therapy has been judged primarily by its effect on airway function rather than on multiaspect asthma control...
  26. ncbi request reprint Corticosteroid pharmacogenetics: association of sequence variants in CRHR1 with improved lung function in asthmatics treated with inhaled corticosteroids
    Kelan G Tantisira
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Hum Mol Genet 13:1353-9. 2004
    ....
  27. pmc Mouse allergens in urban elementary schools and homes of children with asthma
    William J Sheehan
    Division of Allergy and Immunology, Department of Pediatrics, Children s Hospital, Boston, Massachusetts 02115, USA
    Ann Allergy Asthma Immunol 102:125-30. 2009
    ..The association between allergens in schools and childhood asthma has not been well studied, particularly in the United States...
  28. ncbi request reprint Pharmacogenetics of treatment with leukotriene modifiers
    Michael E Wechsler
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Opin Allergy Clin Immunol 2:395-401. 2002
    ..This review highlights the importance of pharmacogenetic associations of an important class of asthma therapy, the leukotriene modifiers, and asthma...
  29. ncbi request reprint Relating maximum airway dilation and subsequent reconstriction to reactivity in human lungs
    Lauren D Black
    Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA
    J Appl Physiol (1985) 96:1808-14. 2004
    ..We conclude that preventing DIs does not ensure that healthy subjects will transition entirely to an asthmatic-like hyperreactive lung state...
  30. ncbi request reprint Exhaled nitric oxide as a diagnostic test for asthma: online versus offline techniques and effect of flow rate
    Aaron Deykin
    Pulmonary and Critical Care Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 165:1597-601. 2002
    ..07 with the fastest offline method, p = 0.46). These data indicate that the choice of expiratory flow rate and collection method can be based on practicality and patient comfort without compromising the utility of this test for asthma...
  31. ncbi request reprint Effects of allergen challenge on airway epithelial cell gene expression
    Craig M Lilly
    Pulmonary and Critical Care Division, Brigham and Women s Hospital, 75 Francis Street, Thorn 826C, Boston, MA 02115, USA
    Am J Respir Crit Care Med 171:579-86. 2005
    ....
  32. ncbi request reprint Inhaled corticosteroids effects on bone in asthmatic and COPD patients: a quantitative systematic review
    Florent Richy
    WHO Collaborating Center for Public Health Aspects of Osteoarticular Disorders, Liege, Belgium
    Osteoporos Int 14:179-90. 2003
    ..These findings could have practical implication in the long-term management of asthmatic and COPD patients...
  33. ncbi request reprint LTC4 production by eosinophils in asthmatic subjects with alternative forms of ALOX-5 core promoter
    Omer Kalayci
    Hacettepe University School of Medicine, Pediatric Allergy and Asthma Unit, Ankara, Turkey
    Adv Exp Med Biol 525:11-4. 2003
  34. pmc Alterations of the arginine metabolome in asthma
    Abigail Lara
    Department of Pathobiology, The Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Am J Respir Crit Care Med 178:673-81. 2008
    ..As the sole nitrogen donor in nitric oxide (NO) synthesis and key intermediate in the urea cycle, arginine and its metabolic pathways are integrally linked to cellular respiration, metabolism, and inflammation...
  35. ncbi request reprint Impact of a soluble phospholipase A2 inhibitor on inhaled allergen challenge in subjects with asthma
    David L Bowton
    Department of Anesthesiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1009, USA
    J Asthma 42:65-71. 2005
    ..The response to inhaled allergen challenge was reproducible and confirms the utility of this technique as a model in which to screen compounds for further testing in asthmatic patients...
  36. ncbi request reprint Significant variability in response to inhaled corticosteroids for persistent asthma
    Stanley J Szefler
    National Jewish Medical and Research Center, Department of Pediatrics, Denver, CO 80206, USA
    J Allergy Clin Immunol 109:410-8. 2002
    ..A clinical model is needed to compare inhaled corticosteroids (ICSs) with respect to efficacy...
  37. pmc Smoking affects response to inhaled corticosteroids or leukotriene receptor antagonists in asthma
    Stephen C Lazarus
    University of California, San Francisco, 505 Parnassus Avenue, M 1083, San Francisco, CA 94143 0111, USA
    Am J Respir Crit Care Med 175:783-90. 2007
    ..One-quarter to one-third of individuals with asthma smoke, which may affect response to therapy and contribute to poor asthma control...
  38. pmc The Predicting Response to Inhaled Corticosteroid Efficacy (PRICE) trial
    Richard J Martin
    National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 119:73-80. 2007
    ..Although guidelines recommend anti-inflammatory therapy for persistent asthma, recent studies suggest that 25% to 35% of patients with asthma may not improve lung function with inhaled corticosteroids...
  39. ncbi request reprint beta-adrenergic receptor genotype and response to salmeterol
    Michael E Wechsler
    J Allergy Clin Immunol 120:218-9; author reply 219-20. 2007
  40. ncbi request reprint Clinical Decisions. Treatment of mild persistent asthma
    Monica Kraft
    N Engl J Med 356:2096-100. 2007
  41. ncbi request reprint Lung function in adults with stable but severe asthma: air trapping and incomplete reversal of obstruction with bronchodilation
    Ronald L Sorkness
    Univ of Wisconsin, 777 Highland Ave, Madison, WI 53705, USA
    J Appl Physiol (1985) 104:394-403. 2008
    ..We conclude that air trapping is a characteristic feature of the severe asthma population, suggesting that there is a pathological process associated with severe asthma that makes airways more vulnerable to this component...
  42. pmc Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program
    Wendy C Moore
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 119:405-13. 2007
    ..Severe asthma causes the majority of asthma morbidity. Understanding mechanisms that contribute to the development of severe disease is important...
  43. ncbi request reprint Daily versus as-needed corticosteroids for mild persistent asthma
    Homer A Boushey
    University of California at San Francisco, San Francisco, USA
    N Engl J Med 352:1519-28. 2005
    ....
  44. ncbi request reprint Spirometry can be done in family physicians' offices and alters clinical decisions in management of asthma and COPD
    Barbara P Yawn
    Olmsted Medical Center, Department of Research, 210 Ninth St SE, Rochester, MN 55904, USA
    Chest 132:1162-8. 2007
    ..While many patients with asthma and COPD are cared for by primary care practices, limited data are available on the use and results associated with spirometry in primary care...
  45. pmc IL4R alpha mutations are associated with asthma exacerbations and mast cell/IgE expression
    Sally E Wenzel
    University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Am J Respir Crit Care Med 175:570-6. 2007
    ..However, an effect on exacerbations and tissue inflammation has not been shown...
  46. pmc Subspecialty differences in asthma characteristics and management
    Hubert Chen
    Division of Pulmonary and Critical Care Medicine, University of California San Francisco, CA, USA
    Mayo Clin Proc 83:786-93. 2008
    ..To determine the nature and extent to which asthma characteristics and management differ between allergy and pulmonary subspecialists...