Affiliation: Massachusetts General Hospital
- Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trialElliot Israel
Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Lancet 364:1505-12. 2004..However, the existence of any genotype-dependent difference has not been tested in a prospective clinical trial...
- Combination therapy with a long-acting beta-agonist and a leukotriene antagonist in moderate asthmaAaron Deykin
Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Am J Respir Crit Care Med 175:228-34. 2007..The elements of asthma control achieved by LABAs (improved lung function) and leukotriene receptor antagonists (LTRAs; protection against exacerbations) may be complementary as well...
- Effect of beta2-adrenergic receptor polymorphism on response to longacting beta2 agonist in asthma (LARGE trial): a genotype-stratified, randomised, placebo-controlled, crossover trialMichael E Wechsler
Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Lancet 374:1754-64. 2009..We investigated whether there is a genotype-specific response to treatment with a longacting beta2 agonist in combination with inhaled corticosteroid...
- beta-Adrenergic receptor polymorphisms and response to salmeterolMichael E Wechsler
Brigham and Women s Hospital, 75 Francis Street, Boston, MA, 02115, USA
Am J Respir Crit Care Med 173:519-26. 2006..Several studies suggest that patients with asthma who are homozygous for arginine at the 16th position of the beta2-adrenergic receptor may not benefit from short-acting beta-agonists...
- Impact of race on asthma treatment failures in the asthma clinical research networkMichael E Wechsler
Brigham and Women s Hospital, Boston, MA 02115, USA
Am J Respir Crit Care Med 184:1247-53. 2011..Recent studies suggest that people with asthma of different racial backgrounds may respond differently to various therapies...
- Sputum eosinophil counts predict asthma control after discontinuation of inhaled corticosteroidsAaron Deykin
Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
J Allergy Clin Immunol 115:720-7. 2005..Although inhaled corticosteroids (ICSs) are effective in preventing deterioration in asthma control, at least half of subjects with mild-to-moderate asthma will remain stable when these agents are discontinued...
- Active albuterol or placebo, sham acupuncture, or no intervention in asthmaMichael E Wechsler
Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
N Engl J Med 365:119-26. 2011..We compared the effects of a bronchodilator, two placebo interventions, and no intervention on outcomes in patients with asthma...
- Genetics and the variability of treatment response in asthmaElliot Israel
Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass, USA
J Allergy Clin Immunol 115:S532-8. 2005....
- Cysteinyl leukotriene antagonism inhibits bronchoconstriction in response to hypertonic saline inhalation in asthmaShamsah Kazani
Pulmonary and Critical Care Division, Department of Medicine, Brigham and Women s Hospital, PBB Clinics 3, 75 Francis Street, Boston, MA 02115, USA
Respir Med 105:667-73. 2011..Whether polymorphisms in the leukotriene biosynthetic pathway affect the contribution of CysLTs to this response is also unknown...
- How pharmacogenomics will play a role in the management of asthmaMichael E Wechsler
Pulmonary and Critical Care Division, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA
Am J Respir Crit Care Med 172:12-8. 2005
- Genome-wide association identifies the T gene as a novel asthma pharmacogenetic locusKelan G Tantisira
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
Am J Respir Crit Care Med 185:1286-91. 2012..To date, most studies aimed at discovering genetic factors influencing treatment response in asthma have focused on biologic candidate genes. Genome-wide association studies (GWAS) can rapidly identify novel pharmacogenetic loci...
- Airway lipoxin A4 generation and lipoxin A4 receptor expression are decreased in severe asthmaAnna Planagumà
Pulmonary and Critical Care Medicine Division, Department of Internal Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
Am J Respir Crit Care Med 178:574-82. 2008..Airway inflammation is common in severe asthma despite antiinflammatory therapy with corticosteroids. Lipoxin A(4) (LXA(4)) is an arachidonic acid-derived mediator that serves as an agonist for resolution of inflammation...
- The role of pharmacogenomics in improving the management of asthmaShamsah Kazani
Pulmonary and Critical Care Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Allergy Clin Immunol 125:295-302; quiz 303-4. 2010..We explore the data developed from the early pharmacogenomic studies with the most common asthma therapies. Furthermore, we explore the potential use of pharmacogenomics, as well as caveats in interpreting such information...
- Mepolizumab as a steroid-sparing treatment option in patients with Churg-Strauss syndromeSophia Kim
Department of Pediatrics, Children s Hospital Boston, Boston, Mass, USA
J Allergy Clin Immunol 125:1336-43. 2010..Levels of IL-5, a cytokine regulating eosinophils, can be increased in patients with CSS. Mepolizumab, a humanized monoclonal anti-IL-5 antibody, decreases steroid requirements in patients with non-CSS hypereosinophilic syndromes...
- Diminished lipoxin biosynthesis in severe asthmaBruce D Levy
Pulmonary and Critical Care Medicine and Partners Asthma Center, Department of Internal Medicine, PBB Clinics 3, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
Am J Respir Crit Care Med 172:824-30. 2005..Although arachidonic acid metabolism is well appreciated to regulate airway inflammation and reactivity, alterations in the biosynthetic capacity for both pro- and antiinflammatory eicosanoids in severe asthma have not been determined...
- The combined effects of zafirlukast, prednisone, and inhaled budesonide on IL-13 and IFN-gamma secretionFiona K Gibbons
Pulmonary and Critical Care Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, 02114, USA
J Clin Immunol 25:437-44. 2005..018) and allergen-specific lymphocyte proliferation (p = 0.02), while IL-13 secretion was unchanged (p = 0.109). This study indicates a role for Th1 cytokines as well as Th2 cytokines in the allergic response...
- Protectin D1 is generated in asthma and dampens airway inflammation and hyperresponsivenessBruce D Levy
Pulmonary and Critical Care Medicine, Department of Internal Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
J Immunol 178:496-502. 2007..Together, these findings provide evidence for endogenous PD1 as a pivotal counterregulatory signal in allergic airway inflammation and point to new therapeutic strategies for modulating inflammation in asthmatic lung...
- Exhaled breath condensates in asthma: diagnostic and therapeutic implicationsShamsah Kazani
Pulmonary and Critical Care Division, PBB Clinics 3, 75 Francis Street, Boston, MA 02115, USA
J Breath Res 4:047001. 2010....
- Genome-wide association analysis in asthma subjects identifies SPATS2L as a novel bronchodilator response geneBlanca E Himes
Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
PLoS Genet 8:e1002824. 2012....
- Effects of montelukast and beclomethasone on airway function and asthma controlElliot Israel
Brigham and Women's Hospital, Boston, MA 02115, USA
J Allergy Clin Immunol 110:847-54. 2002..CONCLUSIONS: Montelukast was as effective as beclomethasone, as judged by indices of clinical control other than FEV(1). When evaluating the outcome of montelukast therapy, FEV(1) might underestimate clinical effectiveness...
- Corticosteroid pharmacogenetics: association of sequence variants in CRHR1 with improved lung function in asthmatics treated with inhaled corticosteroidsKelan G Tantisira
Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Hum Mol Genet 13:1353-9. 2004....
- Mouse allergens in urban elementary schools and homes of children with asthmaWilliam J Sheehan
Division of Allergy and Immunology, Department of Pediatrics, Children s Hospital, Boston, Massachusetts 02115, USA
Ann Allergy Asthma Immunol 102:125-30. 2009..The association between allergens in schools and childhood asthma has not been well studied, particularly in the United States...
- Exhaled nitric oxide as a diagnostic test for asthma: online versus offline techniques and effect of flow rateAaron Deykin
Pulmonary and Critical Care Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Am J Respir Crit Care Med 165:1597-601. 2002..07 with the fastest offline method, p = 0.46). These data indicate that the choice of expiratory flow rate and collection method can be based on practicality and patient comfort without compromising the utility of this test for asthma...
- Pharmacogenetics of treatment with leukotriene modifiersMichael E Wechsler
Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Curr Opin Allergy Clin Immunol 2:395-401. 2002....
- Effects of allergen challenge on airway epithelial cell gene expressionCraig M Lilly
Pulmonary and Critical Care Division, Brigham and Women s Hospital, 75 Francis Street, Thorn 826C, Boston, MA 02115, USA
Am J Respir Crit Care Med 171:579-86. 2005....
- Relating maximum airway dilation and subsequent reconstriction to reactivity in human lungsLauren D Black
Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA
J Appl Physiol 96:1808-14. 2004..We conclude that preventing DIs does not ensure that healthy subjects will transition entirely to an asthmatic-like hyperreactive lung state...
- Alterations of the arginine metabolome in asthmaAbigail Lara
Department of Pathobiology, The Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
Am J Respir Crit Care Med 178:673-81. 2008..As the sole nitrogen donor in nitric oxide (NO) synthesis and key intermediate in the urea cycle, arginine and its metabolic pathways are integrally linked to cellular respiration, metabolism, and inflammation...
- LTC4 production by eosinophils in asthmatic subjects with alternative forms of ALOX-5 core promoterOmer Kalayci
Hacettepe University School of Medicine, Pediatric Allergy and Asthma Unit, Ankara, Turkey
Adv Exp Med Biol 525:11-4. 2003
- Inhaled corticosteroids effects on bone in asthmatic and COPD patients: a quantitative systematic reviewFlorent Richy
WHO Collaborating Center for Public Health Aspects of Osteoarticular Disorders, Liege, Belgium
Osteoporos Int 14:179-90. 2003..These findings could have practical implication in the long-term management of asthmatic and COPD patients...
- Significant variability in response to inhaled corticosteroids for persistent asthmaStanley J Szefler
National Jewish Medical and Research Center, Department of Pediatrics, Denver, CO 80206, USA
J Allergy Clin Immunol 109:410-8. 2002..It is possible that higher doses of ICSs are necessary to manage more severe patients or to achieve goals of therapy not evaluated in this study, such as prevention of asthma exacerbations...
- beta-adrenergic receptor genotype and response to salmeterolMichael E Wechsler
J Allergy Clin Immunol 120:218-9; author reply 219-20. 2007
- Impact of a soluble phospholipase A2 inhibitor on inhaled allergen challenge in subjects with asthmaDavid L Bowton
Department of Anesthesiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1009, USA
J Asthma 42:65-71. 2005..The response to inhaled allergen challenge was reproducible and confirms the utility of this technique as a model in which to screen compounds for further testing in asthmatic patients...
- Lung function in adults with stable but severe asthma: air trapping and incomplete reversal of obstruction with bronchodilationRonald L Sorkness
Univ of Wisconsin, 777 Highland Ave, Madison, WI 53705, USA
J Appl Physiol 104:394-403. 2008..We conclude that air trapping is a characteristic feature of the severe asthma population, suggesting that there is a pathological process associated with severe asthma that makes airways more vulnerable to this component...
- Daily versus as-needed corticosteroids for mild persistent asthmaHomer A Boushey
University of California at San Francisco, San Francisco, USA
N Engl J Med 352:1519-28. 2005..Further studies are required to determine whether this novel approach to treatment should be recommended...
- Clinical Decisions. Treatment of mild persistent asthmaMonica Kraft
N Engl J Med 356:2096-100. 2007
- Smoking affects response to inhaled corticosteroids or leukotriene receptor antagonists in asthmaStephen C Lazarus
University of California, San Francisco, 505 Parnassus Avenue, M 1083, San Francisco, CA 94143 0111, USA
Am J Respir Crit Care Med 175:783-90. 2007..One-quarter to one-third of individuals with asthma smoke, which may affect response to therapy and contribute to poor asthma control...
- Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research ProgramWendy C Moore
Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
J Allergy Clin Immunol 119:405-13. 2007..Severe asthma causes the majority of asthma morbidity. Understanding mechanisms that contribute to the development of severe disease is important...
- The Predicting Response to Inhaled Corticosteroid Efficacy (PRICE) trialRichard J Martin
National Jewish Medical and Research Center, Denver, CO 80206, USA
J Allergy Clin Immunol 119:73-80. 2007..Although guidelines recommend anti-inflammatory therapy for persistent asthma, recent studies suggest that 25% to 35% of patients with asthma may not improve lung function with inhaled corticosteroids...
- Subspecialty differences in asthma characteristics and managementHubert Chen
Division of Pulmonary and Critical Care Medicine, University of California San Francisco, CA, USA
Mayo Clin Proc 83:786-93. 2008..To determine the nature and extent to which asthma characteristics and management differ between allergy and pulmonary subspecialists...
- Spirometry can be done in family physicians' offices and alters clinical decisions in management of asthma and COPDBarbara P Yawn
Olmsted Medical Center, Department of Research, 210 Ninth St SE, Rochester, MN 55904, USA
Chest 132:1162-8. 2007..While many patients with asthma and COPD are cared for by primary care practices, limited data are available on the use and results associated with spirometry in primary care...
- IL4R alpha mutations are associated with asthma exacerbations and mast cell/IgE expressionSally E Wenzel
University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
Am J Respir Crit Care Med 175:570-6. 2007..However, an effect on exacerbations and tissue inflammation has not been shown...