Krista F Huybrechts

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc National trends in antidepressant medication treatment among publicly insured pregnant women
    Krista F Huybrechts
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02120, USA
    Gen Hosp Psychiatry 35:265-71. 2013
  2. pmc Comparative safety of antipsychotic medications in nursing home residents
    Krista F Huybrechts
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02120, USA
    J Am Geriatr Soc 60:420-9. 2012
  3. pmc Differential risk of death in older residents in nursing homes prescribed specific antipsychotic drugs: population based cohort study
    K F Huybrechts
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, 02120 MA, United States
    BMJ 344:e977. 2012
  4. doi request reprint Variation in antipsychotic treatment choice across US nursing homes
    Krista F Huybrechts
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02120, USA
    J Clin Psychopharmacol 32:11-7. 2012
  5. pmc Risk of death and hospital admission for major medical events after initiation of psychotropic medications in older adults admitted to nursing homes
    Krista F Huybrechts
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass, USA
    CMAJ 183:E411-9. 2011
  6. pmc Comparison of different approaches to confounding adjustment in a study on the association of antipsychotic medication with mortality in older nursing home patients
    Krista F Huybrechts
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 1620 Tremont Street, Suite 3030, Boston, MA 02120, USA
    Am J Epidemiol 174:1089-99. 2011
  7. pmc Antidepressant use and risk for preeclampsia
    Kristin Palmsten
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Epidemiology 24:682-91. 2013
  8. pmc Development of a comorbidity index for use in obstetric patients
    Brian T Bateman
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, The Department of Anesthesiology, Critical Care, and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, and the Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts the Department of Anesthesiology, University of Michigan Health System, Ann Arbor, Michigan and the Division of Reproductive Health, Centers for Disease Control and Prevention, Atlanta, Georgia
    Obstet Gynecol 122:957-65. 2013
  9. pmc Statins and congenital malformations: cohort study
    Brian T Bateman
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA Division of Obstetric Anesthesia, Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    BMJ 350:h1035. 2015
  10. doi request reprint Antidepressant use late in pregnancy and risk of persistent pulmonary hypertension of the newborn
    Krista F Huybrechts
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts2Harvard Medical School, Boston, Massachusetts
    JAMA 313:2142-51. 2015

Detail Information

Publications31

  1. pmc National trends in antidepressant medication treatment among publicly insured pregnant women
    Krista F Huybrechts
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02120, USA
    Gen Hosp Psychiatry 35:265-71. 2013
    ..The risk of depression in women is greatest at childbearing age. We sought to examine and explain national trends in antidepressant use in pregnant women...
  2. pmc Comparative safety of antipsychotic medications in nursing home residents
    Krista F Huybrechts
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02120, USA
    J Am Geriatr Soc 60:420-9. 2012
    ..To compare the risk of major medical events in nursing home residents newly initiated on conventional or atypical antipsychotic medications (APMs)...
  3. pmc Differential risk of death in older residents in nursing homes prescribed specific antipsychotic drugs: population based cohort study
    K F Huybrechts
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, 02120 MA, United States
    BMJ 344:e977. 2012
    ..To assess risks of mortality associated with use of individual antipsychotic drugs in elderly residents in nursing homes...
  4. doi request reprint Variation in antipsychotic treatment choice across US nursing homes
    Krista F Huybrechts
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02120, USA
    J Clin Psychopharmacol 32:11-7. 2012
    ..The objective of this study was to quantify the variation in antipsychotic treatment choice across US nursing homes, and to characterize its correlates...
  5. pmc Risk of death and hospital admission for major medical events after initiation of psychotropic medications in older adults admitted to nursing homes
    Krista F Huybrechts
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass, USA
    CMAJ 183:E411-9. 2011
    ..We assessed the comparative safety of different classes of psychotropic medications used in nursing home residents...
  6. pmc Comparison of different approaches to confounding adjustment in a study on the association of antipsychotic medication with mortality in older nursing home patients
    Krista F Huybrechts
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 1620 Tremont Street, Suite 3030, Boston, MA 02120, USA
    Am J Epidemiol 174:1089-99. 2011
    ....
  7. pmc Antidepressant use and risk for preeclampsia
    Kristin Palmsten
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Epidemiology 24:682-91. 2013
    ..US nationwide Medicaid Analytic eXtract (MAX) data have not been used to study medication safety during pregnancy...
  8. pmc Development of a comorbidity index for use in obstetric patients
    Brian T Bateman
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, The Department of Anesthesiology, Critical Care, and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, and the Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts the Department of Anesthesiology, University of Michigan Health System, Ann Arbor, Michigan and the Division of Reproductive Health, Centers for Disease Control and Prevention, Atlanta, Georgia
    Obstet Gynecol 122:957-65. 2013
    ..To develop and validate a maternal comorbidity index to predict severe maternal morbidity, defined as the occurrence of acute maternal end-organ injury, or mortality...
  9. pmc Statins and congenital malformations: cohort study
    Brian T Bateman
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA Division of Obstetric Anesthesia, Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    BMJ 350:h1035. 2015
    ..To examine the teratogenic potential of statins...
  10. doi request reprint Antidepressant use late in pregnancy and risk of persistent pulmonary hypertension of the newborn
    Krista F Huybrechts
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts2Harvard Medical School, Boston, Massachusetts
    JAMA 313:2142-51. 2015
    ....
  11. pmc Use of antidepressants near delivery and risk of postpartum hemorrhage: cohort study of low income women in the United States
    Kristin Palmsten
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    BMJ 347:f4877. 2013
    ..To determine whether use of serotonin or non-serotonin reuptake inhibitors near to delivery is associated with postpartum hemorrhage...
  12. pmc Calcium Channel Blocker Exposure in Late Pregnancy and the Risk of Neonatal Seizures
    Brian T Bateman
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, and the Division of Endocrinology, Diabetes and Metabolism, Brigham and Women s Hospital and Harvard Medical School, the Departments of Anesthesiology, Critical Care, and Pain Medicine and Obstetrics and Gynecology, Massachusetts General Hospital, Harvard Medical School, and the Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts
    Obstet Gynecol 126:271-8. 2015
    ..To assess whether maternal calcium channel blocker exposure during late pregnancy is independently associated with neonatal seizures after carefully controlling for confounding factors...
  13. pmc Chronic hypertension in pregnancy and the risk of congenital malformations: a cohort study
    Brian T Bateman
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA Department of Anesthesiology, Critical Care, and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA Electronic address
    Am J Obstet Gynecol 212:337.e1-14. 2015
    ..Chronic hypertension is a common medical condition in pregnancy. The purpose of the study was to examine the association between maternal chronic hypertension and the risk of congenital malformations in the offspring...
  14. pmc Patterns of opioid utilization in pregnancy in a large cohort of commercial insurance beneficiaries in the United States
    Brian T Bateman
    From the Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, and Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts B T B Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts S H D Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts J P R and Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts J D S, M D, M A F, K F H
    Anesthesiology 120:1216-24. 2014
    ..There are few data regarding the utilization of opioids during pregnancy. The objective of this study was to define the prevalence and patterns of opioid use in a large cohort of pregnant women who were commercial insurance beneficiaries...
  15. pmc Methylergonovine maleate and the risk of myocardial ischemia and infarction
    Brian T Bateman
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Boston, MA Department of Anesthesiology, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, MA Harvard Medical School, Boston, MA
    Am J Obstet Gynecol 209:459.e1-459.e13. 2013
    ....
  16. pmc A prospective cohort study of menstrual characteristics and time to pregnancy
    Lauren A Wise
    Slone Epidemiology Center at Boston University, 1010 Commonwealth Avenue, Fourth Floor, Boston, MA 02215, USA
    Am J Epidemiol 174:701-9. 2011
    ..In the present study, shorter cycle length was associated with delayed time to pregnancy. Age at menarche, time to menstrual regularization, and duration or intensity of menstrual flow were not appreciably associated with fecundability...
  17. pmc Exposure to prescription opioid analgesics in utero and risk of neonatal abstinence syndrome: population based cohort study
    Rishi J Desai
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02120, USA
    BMJ 350:h2102. 2015
    ....
  18. pmc Antipsychotics and mortality: adjusting for mortality risk scores to address confounding by terminal illness
    Yoonyoung Park
    Department of Epidemiology, School of Public Health, Harvard University, Boston, Massachusetts Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, School of Medicine, Harvard University, Boston, Massachusetts
    J Am Geriatr Soc 63:516-23. 2015
    ..To determine whether adjustment for prognostic indices specifically developed for nursing home (NH) populations affect the magnitude of previously observed associations between mortality and conventional and atypical antipsychotics...
  19. pmc Estimation using all available covariate information versus a fixed look-back window for dichotomous covariates
    Steven M Brunelli
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02120, USA
    Pharmacoepidemiol Drug Saf 22:542-50. 2013
    ..When available historical data differs among subjects, investigators must choose between using all available historical data versus data from a fixed window to assess C. Our purpose was to compare estimation under these two approaches...
  20. pmc Patterns of outpatient antihypertensive medication use during pregnancy in a Medicaid population
    Brian T Bateman
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Hypertension 60:913-20. 2012
    ..1%) in the third trimester. Antihypertensive use during pregnancy is relatively common and increasing. The wide range of agents used during pregnancy includes medications considered contraindicated during pregnancy...
  21. pmc Instrumental variable applications using nursing home prescribing preferences in comparative effectiveness research
    Krista F Huybrechts
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Pharmacoepidemiol Drug Saf 23:830-8. 2014
    ..We evaluated the validity of instrumental variable (IV) methods based on nursing home prescribing preference to mitigate such confounding, using psychotropic medications to manage behavioral problems in dementia as a case study...
  22. pmc Evaluating possible confounding by prescriber in comparative effectiveness research
    Jessica M Franklin
    From the Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA
    Epidemiology 26:238-41. 2015
    ..Therefore, we recommend caution when using the IV approach, particularly when the instrument is weak. Stratification on the prescriber may be more robust; this approach warrants additional research. ..
  23. pmc The Most Commonly Dispensed Prescription Medications Among Pregnant Women Enrolled in the U.S. Medicaid Program
    Kristin Palmsten
    Departments of Pediatrics and Family Medicine and Public Health and the Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California and the Department of Epidemiology, Harvard School of Public Health, The Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts
    Obstet Gynecol 126:465-73. 2015
    ..S. Food and Drug Administration categories D or X dispensed to pregnant women enrolled in the U.S. Medicaid program...
  24. pmc Validity of maternal and infant outcomes within nationwide Medicaid data
    Kristin Palmsten
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA
    Pharmacoepidemiol Drug Saf 23:646-55. 2014
    ....
  25. pmc Effects of adjusting for instrumental variables on bias and precision of effect estimates
    Jessica A Myers
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02120, USA
    Am J Epidemiol 174:1213-22. 2011
    ..In these cases, minimizing unmeasured confounding should be the priority when selecting variables for adjustment, even at the risk of conditioning on IVs...
  26. pmc Prescription drug insurance coverage and patient health outcomes: a systematic review
    Aaron S Kesselheim
    Aaron S Kesselheim, Krista F Huybrechts, Niteesh K Choudhry, Lisa A Fulchino, Danielle L Isaman, and Mary K Kowal are with the Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA Troyen A Brennan is with CVS Caremark, Woonsocket, RI
    Am J Public Health 105:e17-30. 2015
    ..States should consider implementing the Affordable Care Act expansions in drug coverage to improve the health of low-income patients receiving state-based health insurance. ..
  27. pmc Patterns of second-line uterotonic use in a large sample of hospitalizations for childbirth in the United States: 2007-2011
    Brian T Bateman
    From the Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts Department of Anesthesiology, Critical Care, and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts and Department of Anesthesia, Stanford University School of Medicine, Stanford, California
    Anesth Analg 119:1344-9. 2014
    ..In this study, we describe hospital-level patterns of second-line uterotonic use in a large, nationwide sample of admissions for childbirth in the United States...
  28. pmc Increase in prescription opioid use during pregnancy among Medicaid-enrolled women
    Rishi J Desai
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, The Department of Epidemiology, Harvard School of Public Health, and the Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts
    Obstet Gynecol 123:997-1002. 2014
    ..To report the prevalence of prescription opioid use and evaluate the trends in a large cohort of Medicaid-enrolled pregnant women...
  29. pmc Electronic medication packaging devices and medication adherence: a systematic review
    Kyle D Checchi
    Program on Regulation, Therapeutics, and Law, Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts
    JAMA 312:1237-47. 2014
    ....
  30. pmc Preterm birth and antidepressant medication use during pregnancy: a systematic review and meta-analysis
    Krista F Huybrechts
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 9:e92778. 2014
    ..5% in the US. The objective was to systematically review the literature to determine the strength of the available evidence relating to a possible association between antidepressant use during pregnancy and preterm birth...
  31. pmc A successful implementation of e-epidemiology: the Danish pregnancy planning study 'Snart-Gravid'
    Krista F Huybrechts
    Department of Epidemiology, Boston University School of Public Health, Boston, MA 02118, USA
    Eur J Epidemiol 25:297-304. 2010
    ..The successful conduct of this pilot study suggests that the internet may be a useful tool to recruit and follow subjects in prospective cohort studies...