Research Topics
Species | Bryan P HurleySummaryAffiliation: Massachusetts General Hospital Country: USA Publications
Research Grants
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Detail Information
Publications
Selective eicosanoid-generating capacity of cytoplasmic phospholipase A2 in Pseudomonas aeruginosa-infected epithelial cellsBryan P Hurley
Mucosal Immunology, Massachusetts General Hospital, Charlestown, 02129, USA
Am J Physiol Lung Cell Mol Physiol 300:L286-94. 2011..The therapeutic implications of these findings are significant when considering anti-inflammatory therapies based on targeting eicosanoid synthesis pathways...- The two-component sensor response regulator RoxS/RoxR plays a role in Pseudomonas aeruginosa interactions with airway epithelial cellsBryan P Hurley
Mucosal Immunology Laboratory, Massachusetts General Hospital, Charlestown MA 02129, USA
Microbes Infect 12:190-8. 2010..This finding suggests that RoxR likely regulates genes with relevance to P. aeruginosa mediated lung disease... 
Involvement of phospholipase A2 in Pseudomonas aeruginosa-mediated PMN transepithelial migrationBryan P Hurley
Mucosal Immunology Laboratories, Massachusetts General Hospital, 3503 Charlestown, MA 02129, USA
Am J Physiol Lung Cell Mol Physiol 290:L703-L709. 2006..aeruginosa activates cPLA(2) generating free AA that may be converted to HXA(3), which is required for mediating PMN transmigration...- Multiple roles of phospholipase A2 during lung infection and inflammationBryan P Hurley
Mucosal Immunology Laboratories, Massachusetts General Hospital, CNY 114 (114-3503, Charlestown, MA 02129, USA
Infect Immun 76:2259-72. 2008 - Hepoxilin A(3) facilitates neutrophilic breach of lipoxygenase-expressing airway epithelial barriersDavid L Tamang
Mucosal Immunology Laboratory, Massachusetts General Hospital, Charlestown, MA 02129, USA
J Immunol 189:4960-9. 2012..Data generated from multiple models in this study provide further evidence that hepoxilin A(3) is produced in response to lung pathogenic bacteria and functions to drive neutrophils across epithelial barriers... - Distinct isoforms of phospholipase A2 mediate the ability of Salmonella enterica serotype typhimurium and Shigella flexneri to induce the transepithelial migration of neutrophilsKaren L Mumy
Mucosal Immunology Laboratory, Massachusetts General Hospital, Charlestown, Massachusetts, USA
Infect Immun 76:3614-27. 2008.... - Salmonella enterica serovar Typhimurium regulates intercellular junction proteins and facilitates transepithelial neutrophil and bacterial passageHenrik Kohler
Mucosal Immunology Laboratories, Massachusetts General Hospital, 114 16th Street, Charlestown, MA 02129, USA
Am J Physiol Gastrointest Liver Physiol 293:G178-87. 2007..Therefore, the ability to regulate the molecular composition of TJs facilitates the pathogenicity of S. typhimurium by aiding its uptake and distribution within the host... - Polymorphonuclear cell transmigration induced by Pseudomonas aeruginosa requires the eicosanoid hepoxilin A3Bryan P Hurley
Mucosal Immunology Laboratory, Massachusetts General Hospital, Charlestown, MA 02129, USA
J Immunol 173:5712-20. 2004..These data suggest that bacterial-induced hepoxilin A3 secretion may represent a previously unrecognized inflammatory mechanism occurring within the lung epithelium during bacterial infections... - Intestinal epithelial defense systems protect against bacterial threatsBryan P Hurley
Mucosal Immunology Laboratory, Massachusetts General Hospital, CNY, 114 16th Street (114-3503, Charlestown, MA 02129, USA
Curr Gastroenterol Rep 6:355-61. 2004..A better understanding of how the intestinal epithelium interacts with its microbial constituents may provide insight into strategies for treatment of enteric infections and inflammatory bowel disease... - Translating tissue culture results into animal models: the case of Salmonella typhimuriumBryan P Hurley
Combined Program in Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital, 114 16th Street (114-3503, Charlestown, MA 02129, USA
Trends Microbiol 11:562-9. 2003..Translating the in vitro findings into the context of an animal model and subsequently to human disease remains a difficult challenge for any disease process... - Identification of hepoxilin A3 in inflammatory events: a required role in neutrophil migration across intestinal epitheliaRandall J Mrsny
School of Pharmacy, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff, Wales CF10 3XF, United Kingdom
Proc Natl Acad Sci U S A 101:7421-6. 2004....
Research Grants
- Airway Inflammation: Bacterial Epithelial InteractionsBRYAN HURLEY; Fiscal Year: 2004..Results obtained from the following proposal may shed light on diseases involving bacterial mediated lung inflammation such as cystic fibrosis and should also provide new strategies directed towards treating lung disease. ..