Bryan P Hurley

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc Multiple roles of phospholipase A2 during lung infection and inflammation
    Bryan P Hurley
    Mucosal Immunology Laboratories, Massachusetts General Hospital, CNY 114 114 3503, Charlestown, MA 02129, USA
    Infect Immun 76:2259-72. 2008
  2. pmc Selective eicosanoid-generating capacity of cytoplasmic phospholipase A2 in Pseudomonas aeruginosa-infected epithelial cells
    Bryan P Hurley
    Mucosal Immunology, Massachusetts General Hospital, Charlestown, 02129, USA
    Am J Physiol Lung Cell Mol Physiol 300:L286-94. 2011
  3. ncbi request reprint Involvement of phospholipase A2 in Pseudomonas aeruginosa-mediated PMN transepithelial migration
    Bryan P Hurley
    Mucosal Immunology Laboratories, Massachusetts General Hospital, 3503 Charlestown, MA 02129, USA
    Am J Physiol Lung Cell Mol Physiol 290:L703-L709. 2006
  4. pmc The two-component sensor response regulator RoxS/RoxR plays a role in Pseudomonas aeruginosa interactions with airway epithelial cells
    Bryan P Hurley
    Mucosal Immunology Laboratory, Massachusetts General Hospital, Charlestown MA 02129, USA
    Microbes Infect 12:190-8. 2010
  5. pmc Hepoxilin A(3) facilitates neutrophilic breach of lipoxygenase-expressing airway epithelial barriers
    David L Tamang
    Mucosal Immunology Laboratory, Massachusetts General Hospital, Charlestown, MA 02129, USA
    J Immunol 189:4960-9. 2012
  6. pmc Distinct isoforms of phospholipase A2 mediate the ability of Salmonella enterica serotype typhimurium and Shigella flexneri to induce the transepithelial migration of neutrophils
    Karen L Mumy
    Mucosal Immunology Laboratory, Massachusetts General Hospital, Charlestown, Massachusetts, USA
    Infect Immun 76:3614-27. 2008
  7. ncbi request reprint Salmonella enterica serovar Typhimurium regulates intercellular junction proteins and facilitates transepithelial neutrophil and bacterial passage
    Henrik Kohler
    Mucosal Immunology Laboratories, Massachusetts General Hospital, 114 16th Street, Charlestown, MA 02129, USA
    Am J Physiol Gastrointest Liver Physiol 293:G178-87. 2007
  8. ncbi request reprint Polymorphonuclear cell transmigration induced by Pseudomonas aeruginosa requires the eicosanoid hepoxilin A3
    Bryan P Hurley
    Mucosal Immunology Laboratory, Massachusetts General Hospital, Charlestown, MA 02129, USA
    J Immunol 173:5712-20. 2004
  9. pmc Role of antilipopolysaccharide antibodies in serum bactericidal activity against Salmonella enterica serovar Typhimurium in healthy adults and children in the United States
    Estela Trebicka
    Mucosal Immunology and Biology Research Center, Division of Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital, Boston, Massachusetts, USA
    Clin Vaccine Immunol 20:1491-8. 2013
  10. ncbi request reprint Intestinal epithelial defense systems protect against bacterial threats
    Bryan P Hurley
    Mucosal Immunology Laboratory, Massachusetts General Hospital, CNY, 114 16th Street 114 3503, Charlestown, MA 02129, USA
    Curr Gastroenterol Rep 6:355-61. 2004

Research Grants

Collaborators

Detail Information

Publications12

  1. pmc Multiple roles of phospholipase A2 during lung infection and inflammation
    Bryan P Hurley
    Mucosal Immunology Laboratories, Massachusetts General Hospital, CNY 114 114 3503, Charlestown, MA 02129, USA
    Infect Immun 76:2259-72. 2008
  2. pmc Selective eicosanoid-generating capacity of cytoplasmic phospholipase A2 in Pseudomonas aeruginosa-infected epithelial cells
    Bryan P Hurley
    Mucosal Immunology, Massachusetts General Hospital, Charlestown, 02129, USA
    Am J Physiol Lung Cell Mol Physiol 300:L286-94. 2011
    ..The therapeutic implications of these findings are significant when considering anti-inflammatory therapies based on targeting eicosanoid synthesis pathways...
  3. ncbi request reprint Involvement of phospholipase A2 in Pseudomonas aeruginosa-mediated PMN transepithelial migration
    Bryan P Hurley
    Mucosal Immunology Laboratories, Massachusetts General Hospital, 3503 Charlestown, MA 02129, USA
    Am J Physiol Lung Cell Mol Physiol 290:L703-L709. 2006
    ..aeruginosa activates cPLA(2) generating free AA that may be converted to HXA(3), which is required for mediating PMN transmigration...
  4. pmc The two-component sensor response regulator RoxS/RoxR plays a role in Pseudomonas aeruginosa interactions with airway epithelial cells
    Bryan P Hurley
    Mucosal Immunology Laboratory, Massachusetts General Hospital, Charlestown MA 02129, USA
    Microbes Infect 12:190-8. 2010
    ..This finding suggests that RoxR likely regulates genes with relevance to P. aeruginosa mediated lung disease...
  5. pmc Hepoxilin A(3) facilitates neutrophilic breach of lipoxygenase-expressing airway epithelial barriers
    David L Tamang
    Mucosal Immunology Laboratory, Massachusetts General Hospital, Charlestown, MA 02129, USA
    J Immunol 189:4960-9. 2012
    ..Data generated from multiple models in this study provide further evidence that hepoxilin A(3) is produced in response to lung pathogenic bacteria and functions to drive neutrophils across epithelial barriers...
  6. pmc Distinct isoforms of phospholipase A2 mediate the ability of Salmonella enterica serotype typhimurium and Shigella flexneri to induce the transepithelial migration of neutrophils
    Karen L Mumy
    Mucosal Immunology Laboratory, Massachusetts General Hospital, Charlestown, Massachusetts, USA
    Infect Immun 76:3614-27. 2008
    ....
  7. ncbi request reprint Salmonella enterica serovar Typhimurium regulates intercellular junction proteins and facilitates transepithelial neutrophil and bacterial passage
    Henrik Kohler
    Mucosal Immunology Laboratories, Massachusetts General Hospital, 114 16th Street, Charlestown, MA 02129, USA
    Am J Physiol Gastrointest Liver Physiol 293:G178-87. 2007
    ..Therefore, the ability to regulate the molecular composition of TJs facilitates the pathogenicity of S. typhimurium by aiding its uptake and distribution within the host...
  8. ncbi request reprint Polymorphonuclear cell transmigration induced by Pseudomonas aeruginosa requires the eicosanoid hepoxilin A3
    Bryan P Hurley
    Mucosal Immunology Laboratory, Massachusetts General Hospital, Charlestown, MA 02129, USA
    J Immunol 173:5712-20. 2004
    ..These data suggest that bacterial-induced hepoxilin A3 secretion may represent a previously unrecognized inflammatory mechanism occurring within the lung epithelium during bacterial infections...
  9. pmc Role of antilipopolysaccharide antibodies in serum bactericidal activity against Salmonella enterica serovar Typhimurium in healthy adults and children in the United States
    Estela Trebicka
    Mucosal Immunology and Biology Research Center, Division of Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital, Boston, Massachusetts, USA
    Clin Vaccine Immunol 20:1491-8. 2013
    ..Typhimurium outer membrane protein and correlated the presence of inhibitory anti-LPS antibodies with human immunodeficiency virus infection. ..
  10. ncbi request reprint Intestinal epithelial defense systems protect against bacterial threats
    Bryan P Hurley
    Mucosal Immunology Laboratory, Massachusetts General Hospital, CNY, 114 16th Street 114 3503, Charlestown, MA 02129, USA
    Curr Gastroenterol Rep 6:355-61. 2004
    ..A better understanding of how the intestinal epithelium interacts with its microbial constituents may provide insight into strategies for treatment of enteric infections and inflammatory bowel disease...
  11. ncbi request reprint Translating tissue culture results into animal models: the case of Salmonella typhimurium
    Bryan P Hurley
    Combined Program in Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital, 114 16th Street 114 3503, Charlestown, MA 02129, USA
    Trends Microbiol 11:562-9. 2003
    ..Translating the in vitro findings into the context of an animal model and subsequently to human disease remains a difficult challenge for any disease process...
  12. pmc Identification of hepoxilin A3 in inflammatory events: a required role in neutrophil migration across intestinal epithelia
    Randall J Mrsny
    School of Pharmacy, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff, Wales CF10 3XF, United Kingdom
    Proc Natl Acad Sci U S A 101:7421-6. 2004
    ....

Research Grants2

  1. Airway Inflammation: Bacterial Epithelial Interactions
    BRYAN HURLEY; Fiscal Year: 2004
    ..Results obtained from the following proposal may shed light on diseases involving bacterial mediated lung inflammation such as cystic fibrosis and should also provide new strategies directed towards treating lung disease. ..