Jennifer F Hughes

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. doi request reprint Sex chromosome-to-autosome transposition events counter Y-chromosome gene loss in mammals
    Jennifer F Hughes
    Whitehead Institute, Cambridge, MA, 02142, USA
    Genome Biol 16:104. 2015
  2. doi request reprint The Biology and Evolution of Mammalian Y Chromosomes
    Jennifer F Hughes
    Whitehead Institute, Howard Hughes Medical Institute, and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142 email
    Annu Rev Genet 49:507-27. 2015
  3. pmc Sequencing of rhesus macaque Y chromosome clarifies origins and evolution of the DAZ (Deleted in AZoospermia) genes
    Jennifer F Hughes
    Howard Hughes Medical Institute, Whitehead Institute, and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA
    Bioessays 34:1035-44. 2012
  4. doi request reprint Genomics and genetics of human and primate y chromosomes
    Jennifer F Hughes
    Howard Hughes Medical Institute, Whitehead Institute, and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA
    Annu Rev Genomics Hum Genet 13:83-108. 2012
  5. pmc Strict evolutionary conservation followed rapid gene loss on human and rhesus Y chromosomes
    Jennifer F Hughes
    Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 483:82-6. 2012
  6. pmc Mammalian Y chromosomes retain widely expressed dosage-sensitive regulators
    Daniel W Bellott
    Whitehead Institute, Howard Hughes Medical Institute, and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Nature 508:494-9. 2014
  7. ncbi request reprint Conservation of Y-linked genes during human evolution revealed by comparative sequencing in chimpanzee
    Jennifer F Hughes
    Howard Hughes Medical Institute, Whitehead Institute, and Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 437:100-3. 2005
  8. pmc Sequencing the mouse Y chromosome reveals convergent gene acquisition and amplification on both sex chromosomes
    Y Q Shirleen Soh
    Whitehead Institute, 9 Cambridge Center, Cambridge, MA 02142, USA Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA
    Cell 159:800-13. 2014
  9. pmc Chimpanzee and human Y chromosomes are remarkably divergent in structure and gene content
    Jennifer F Hughes
    Howard Hughes Medical Institute, Whitehead Institute, and Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 463:536-9. 2010

Research Grants

  1. Sequencing the Chimpanzee Y Chromosome
    Jennifer Hughes; Fiscal Year: 2005

Collaborators

  • David C Page
  • Wesley C Warren
  • Jessica Alföldi
  • Richard A Gibbs
  • Jacob L Mueller
  • Elaine R Mardis
  • Helen Skaletsky
  • Y Q Shirleen Soh
  • Tatyana Pyntikova
  • Laura G Brown
  • Richard K Wilson
  • Natalia Koutseva
  • Tina Graves
  • Colin Kremitzki
  • Robert S Fulton
  • Steve Rozen
  • Daniel W Bellott
  • Susie Rock
  • Patrick J Minx
  • Shannon Dugan
  • Sara Zaghlul
  • Michael Holder
  • Qing Cao
  • Lynne Nazareth
  • Donna M Muzny
  • Qiaoyan Wang
  • Ting Jan Cho
  • Jennifer Watt
  • James E Womack
  • Elaine Owens
  • Yan Ding
  • Pieter de Jong
  • Lora Lewis
  • Ziad Khan
  • William J Murphy
  • Donna Morton
  • Sandy Lee
  • Christian Buhay

Detail Information

Publications9

  1. doi request reprint Sex chromosome-to-autosome transposition events counter Y-chromosome gene loss in mammals
    Jennifer F Hughes
    Whitehead Institute, Cambridge, MA, 02142, USA
    Genome Biol 16:104. 2015
    ..In this species, many Y-linked genes were rescued by transposition to new genomic locations, but until our work presented here, this has been considered an isolated case...
  2. doi request reprint The Biology and Evolution of Mammalian Y Chromosomes
    Jennifer F Hughes
    Whitehead Institute, Howard Hughes Medical Institute, and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142 email
    Annu Rev Genet 49:507-27. 2015
    ....
  3. pmc Sequencing of rhesus macaque Y chromosome clarifies origins and evolution of the DAZ (Deleted in AZoospermia) genes
    Jennifer F Hughes
    Howard Hughes Medical Institute, Whitehead Institute, and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA
    Bioessays 34:1035-44. 2012
    ..Editor's suggested further reading in BioEssays Should Y stay or should Y go: The evolution of non-recombining sex chromosomes Abstract...
  4. doi request reprint Genomics and genetics of human and primate y chromosomes
    Jennifer F Hughes
    Howard Hughes Medical Institute, Whitehead Institute, and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA
    Annu Rev Genomics Hum Genet 13:83-108. 2012
    ..The future sequencing of additional Y chromosomes will provide a basis for a more comprehensive understanding of the evolution of Y chromosomes and their roles in reproductive biology...
  5. pmc Strict evolutionary conservation followed rapid gene loss on human and rhesus Y chromosomes
    Jennifer F Hughes
    Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 483:82-6. 2012
    ..We present an empirical reconstruction of human MSY evolution in which each stratum transitioned from rapid, exponential loss of ancestral genes to strict conservation through purifying selection...
  6. pmc Mammalian Y chromosomes retain widely expressed dosage-sensitive regulators
    Daniel W Bellott
    Whitehead Institute, Howard Hughes Medical Institute, and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Nature 508:494-9. 2014
    ....
  7. ncbi request reprint Conservation of Y-linked genes during human evolution revealed by comparative sequencing in chimpanzee
    Jennifer F Hughes
    Howard Hughes Medical Institute, Whitehead Institute, and Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 437:100-3. 2005
    ..Gene decay in the chimpanzee lineage might be a consequence of positive selection focused elsewhere on the Y chromosome and driven by sperm competition...
  8. pmc Sequencing the mouse Y chromosome reveals convergent gene acquisition and amplification on both sex chromosomes
    Y Q Shirleen Soh
    Whitehead Institute, 9 Cambridge Center, Cambridge, MA 02142, USA Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA
    Cell 159:800-13. 2014
    ..The mouse MSY sequence presents opportunities for experimental studies of a sex-specific chromosome in its entirety, in a genetically tractable model organism. ..
  9. pmc Chimpanzee and human Y chromosomes are remarkably divergent in structure and gene content
    Jennifer F Hughes
    Howard Hughes Medical Institute, Whitehead Institute, and Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 463:536-9. 2010
    ..Although genetic decay may be the principal dynamic in the evolution of newly emergent Y chromosomes, wholesale renovation is the paramount theme in the continuing evolution of chimpanzee, human and perhaps other older MSYs...

Research Grants1

  1. Sequencing the Chimpanzee Y Chromosome
    Jennifer Hughes; Fiscal Year: 2005
    ..However, because of several unique challenges posed by the Y chromosome, a dedicated effort will be required to obtain a complete and accurate sequence of this distinctive region of the chimpanzee genome. ..