Paul Huang

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc Unraveling the links between diabetes, obesity, and cardiovascular disease
    Paul L Huang
    Circ Res 96:1129-31. 2005
  2. pmc Role of endothelial nitric oxide in cerebrovascular regulation
    Dmitriy N Atochin
    Cardiovascular Research Center and Cardiology Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
    Curr Pharm Biotechnol 12:1334-42. 2011
  3. pmc eNOS, metabolic syndrome and cardiovascular disease
    Paul L Huang
    Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Trends Endocrinol Metab 20:295-302. 2009
  4. pmc A comprehensive definition for metabolic syndrome
    Paul L Huang
    Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Dis Model Mech 2:231-7. 2009
  5. ncbi request reprint Nitric oxide and cerebral ischemic preconditioning
    Paul L Huang
    Harvard Medical School, Cardiology Division and Cardiovascular Research Center, Massachusetts General Hospital, 149 Thirteenth Street, Charlestown, MA 02129, USA
    Cell Calcium 36:323-9. 2004
  6. pmc Cardiovascular roles of nitric oxide: a review of insights from nitric oxide synthase gene disrupted mice
    Victor W T Liu
    Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, United States
    Cardiovasc Res 77:19-29. 2008
  7. ncbi request reprint Rapid cerebral ischemic preconditioning in mice deficient in endothelial and neuronal nitric oxide synthases
    Dmitriy N Atochin
    Cardiology Division, Cardiovascular Research Center, Massachusetts General Hospital East, Charlestown, MA 02129, USA
    Stroke 34:1299-303. 2003
  8. ncbi request reprint Role of endothelial nitric oxide synthase in endothelial activation: insights from eNOS knockout endothelial cells
    Peter J Kuhlencordt
    Cardiovascular Research Center, Massachusetts General Hospital East, 149 East 13th St, Charlestown, MA 02129, USA
    Am J Physiol Cell Physiol 286:C1195-202. 2004
  9. ncbi request reprint Endothelial nitric oxide synthase regulates microlymphatic flow via collecting lymphatics
    Jeroen Hagendoorn
    Department of Radiation Oncology, E L Steele Laboratory for Tumor Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Mass 02114, USA
    Circ Res 95:204-9. 2004
  10. pmc Protective effects of statins involving both eNOS and tPA in focal cerebral ischemia
    Minoru Asahi
    Neuroprotection Research Laboratory, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, 02129, USA
    J Cereb Blood Flow Metab 25:722-9. 2005

Collaborators

Detail Information

Publications34

  1. pmc Unraveling the links between diabetes, obesity, and cardiovascular disease
    Paul L Huang
    Circ Res 96:1129-31. 2005
  2. pmc Role of endothelial nitric oxide in cerebrovascular regulation
    Dmitriy N Atochin
    Cardiovascular Research Center and Cardiology Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
    Curr Pharm Biotechnol 12:1334-42. 2011
    ..Pharmacological and genetic manipulations of the endothelial NO system demonstrate the essential roles of endothelial NO synthase in maintenance of vascular tone and cerebral perfusion under normal and pathological conditions...
  3. pmc eNOS, metabolic syndrome and cardiovascular disease
    Paul L Huang
    Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Trends Endocrinol Metab 20:295-302. 2009
    ..This review focuses on endothelial nitric oxide synthase and summarizes evidence that a reduction in the bioavailability of endothelium-derived nitric oxide serves as a key link between metabolic disorders and cardiovascular risk...
  4. pmc A comprehensive definition for metabolic syndrome
    Paul L Huang
    Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Dis Model Mech 2:231-7. 2009
    ..A comprehensive definition for the metabolic syndrome and its key features would facilitate research into its causes and hopefully lead to new insights into pharmacologic and lifestyle treatment approaches...
  5. ncbi request reprint Nitric oxide and cerebral ischemic preconditioning
    Paul L Huang
    Harvard Medical School, Cardiology Division and Cardiovascular Research Center, Massachusetts General Hospital, 149 Thirteenth Street, Charlestown, MA 02129, USA
    Cell Calcium 36:323-9. 2004
    ..This article reviews the effects of NO following cerebral ischemia, the signaling pathways through which NO acts, and its potential roles in cerebral ischemic preconditioning...
  6. pmc Cardiovascular roles of nitric oxide: a review of insights from nitric oxide synthase gene disrupted mice
    Victor W T Liu
    Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, United States
    Cardiovasc Res 77:19-29. 2008
    ..Mice lacking the inducible isoform show reduced hypotension to septic shock. Together, NOS gene knockout mice have been useful tools that complement our other approaches to studying the multiple roles of NO in the cardiovascular system...
  7. ncbi request reprint Rapid cerebral ischemic preconditioning in mice deficient in endothelial and neuronal nitric oxide synthases
    Dmitriy N Atochin
    Cardiology Division, Cardiovascular Research Center, Massachusetts General Hospital East, Charlestown, MA 02129, USA
    Stroke 34:1299-303. 2003
    ..The purpose of this study was to test the hypothesis that nitric oxide is required for preconditioning in an intact animal model of focal ischemia using neuronal and endothelial nitric oxide synthase (nNOS and eNOS) knockout mice...
  8. ncbi request reprint Role of endothelial nitric oxide synthase in endothelial activation: insights from eNOS knockout endothelial cells
    Peter J Kuhlencordt
    Cardiovascular Research Center, Massachusetts General Hospital East, 149 East 13th St, Charlestown, MA 02129, USA
    Am J Physiol Cell Physiol 286:C1195-202. 2004
    ..We propose that eNOS derived NO does not chronically suppress endothelial cell activation in an autocrine fashion but serves to counterbalance signals that mediate activation...
  9. ncbi request reprint Endothelial nitric oxide synthase regulates microlymphatic flow via collecting lymphatics
    Jeroen Hagendoorn
    Department of Radiation Oncology, E L Steele Laboratory for Tumor Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Mass 02114, USA
    Circ Res 95:204-9. 2004
    ..Our results provide the first in vivo evidence that eNOS affects function of the whole microlymphatic system and that it is regulated via the collecting lymphatics...
  10. pmc Protective effects of statins involving both eNOS and tPA in focal cerebral ischemia
    Minoru Asahi
    Neuroprotection Research Laboratory, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, 02129, USA
    J Cereb Blood Flow Metab 25:722-9. 2005
    ..These results suggest that statins protect against stroke by multiple mechanisms involving both eNOS and tPA. The involvement of each pathway may be revealed depending on the choice of experimental stroke model...
  11. pmc NO mediates mural cell recruitment and vessel morphogenesis in murine melanomas and tissue-engineered blood vessels
    Satoshi Kashiwagi
    Edwin L Steele Laboratory, Department of Radiation Oncology, and Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    J Clin Invest 115:1816-27. 2005
    ..These data indicate that endothelial cell-derived NO induces mural cell recruitment as well as subsequent morphogenesis and stabilization of angiogenic vessels...
  12. pmc Rho-kinase inhibition acutely augments blood flow in focal cerebral ischemia via endothelial mechanisms
    Hwa Kyoung Shin
    Department of Radiology, Stroke and Neurovascular Regulation Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Cereb Blood Flow Metab 27:998-1009. 2007
    ..Therefore, rapid nontranscriptional upregulation of eNOS activity by small molecule inhibitors of Rho-kinase may be a viable therapeutic approach in acute stroke...
  13. pmc The phosphorylation state of eNOS modulates vascular reactivity and outcome of cerebral ischemia in vivo
    Dmitriy N Atochin
    Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Boston, MA 02129, USA
    J Clin Invest 117:1961-7. 2007
    ..They also demonstrate the in vivo relevance of posttranslational modification of eNOS in vascular function...
  14. pmc Effects of neuroglobin overexpression on acute brain injury and long-term outcomes after focal cerebral ischemia
    Xiaoying Wang
    Neuroprotection Research Laboratory, Departments of Neurology and Radiology, Massachusetts General Hospital, 149 13th Street, Room 2411A, Charlestown, MA 02129, USA
    Stroke 39:1869-74. 2008
    ..Emerging data suggest that neuroglobin (Ngb) may protect against hypoxic/ischemic neuronal insults. However, the underlying mechanisms in vivo and implications for long-term outcomes are still not well understood...
  15. pmc Loss of insulin signaling in vascular endothelial cells accelerates atherosclerosis in apolipoprotein E null mice
    Christian Rask-Madsen
    Research Division, Joslin Diabetes Center, Boston, MA 02215, USA
    Cell Metab 11:379-89. 2010
    ..Therefore, improving insulin sensitivity in the endothelium of patients with insulin resistance or type 2 diabetes may prevent cardiovascular complications...
  16. ncbi request reprint Endothelial nitric oxide synthase and endothelial dysfunction
    Paul L Huang
    Cardiovascular Research Center and Cardiovascular Division, Massachusetts General Hospital, 149 Thirteenth Street, Charlestown, MA 02129, USA
    Curr Hypertens Rep 5:473-80. 2003
    ..A hypothesis is proposed that the final common pathway of diverse causes of endothelial dysfunction involves abnormalities in eNOS phosphorylation at Ser 1179 and other key phosphorylation sites...
  17. ncbi request reprint Effects of chronic treatment with L-arginine on atherosclerosis in apoE knockout and apoE/inducible NO synthase double-knockout mice
    Jiqiu Chen
    Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    Arterioscler Thromb Vasc Biol 23:97-103. 2003
    ..In the present study, we investigate the effect of L-arginine supplementation on the development of atherosclerosis in a mouse model...
  18. ncbi request reprint Inducible nitric-oxide synthase is an important contributor to prolonged protective effects of ischemic preconditioning in the mouse kidney
    Kwon Moo Park
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Biol Chem 278:27256-66. 2003
    ....
  19. ncbi request reprint Tissue plasminogen activator promotes matrix metalloproteinase-9 upregulation after focal cerebral ischemia
    Kiyoshi Tsuji
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA
    Stroke 36:1954-9. 2005
    ..Here, we used a combination of pharmacological and genetic approaches to show that tPA promotes MMP-9 levels in stroke in vivo...
  20. ncbi request reprint In vivo imaging of proteolytic activity in atherosclerosis
    Jiqiu Chen
    Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, USA
    Circulation 105:2766-71. 2002
    ..On the basis of the hypothesis that the inflammatory response and proteolysis lead to plaque rupture, we have examined the role of cathepsin B as a model proteolytic enzyme...
  21. ncbi request reprint Deletion of exon 6 of the neuronal nitric oxide synthase gene in mice results in hypogonadism and infertility
    Robert Gyurko
    Cardiovascular Research Center and Reproductive Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston 02129, USA
    Endocrinology 143:2767-74. 2002
    ..We conclude that nNOS is required for normal central hormonal regulation of reproductive function...
  22. pmc Soluble guanylate cyclase alpha1beta1 limits stroke size and attenuates neurological injury
    Dmitriy N Atochin
    Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Boston, Mass, USA
    Stroke 41:1815-9. 2010
    ..To study the role of sGC in stroke injury, we compared the outcome of cerebral ischemia and reperfusion in mice deficient in the alpha(1) subunit of sGC (sGCalpha(1)(-/-)) with that in wild-type mice...
  23. ncbi request reprint Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms
    Lili A Barouch
    Department of Medicine Cardiology Division, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Nature 416:337-9. 2002
    ..Thus, NOS1 and NOS3 mediate independent, and in some cases opposite, effects on cardiac structure and function...
  24. ncbi request reprint Stimulation of nitric oxide synthase in cerebral cortex due to elevated partial pressures of oxygen: an oxidative stress response
    Stephen R Thom
    Department of Emergency Medicine, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    J Neurobiol 51:85-100. 2002
    ..We conclude that hyperoxia causes an increase in (*)NO synthesis as part of a response to oxidative stress. Mechanisms for nNOS activation include augmentation in the association with Hsp90 and intracellular entry of calcium...
  25. ncbi request reprint Decreased arteriolar density in endothelial nitric oxide synthase knockout mice is due to hypertension, not to the constitutive defect in endothelial nitric oxide synthase enzyme
    Nathalie Kubis
    INSERM Unit 541, Hopital Lariboisiere, Paris, France
    J Hypertens 20:273-80. 2002
    ..Hypertension in endothelial nitric oxide synthase knockout (eNOS-/-) mice is believed to be partly due to altered vasodilatation. However, nitric oxide (NO) is also known to play an important part in angiogenesis...
  26. pmc Contributions of nitric oxide synthase isoforms to pulmonary oxygen toxicity, local vs. mediated effects
    Ivan T Demchenko
    Center for Hyperbaric Medicine and Environmental Physiology, Duke University Medical Center, Durham, NC 27710, USA
    Am J Physiol Lung Cell Mol Physiol 294:L984-90. 2008
    ..In addition, we demonstrated that nitric oxide derived from nNOS is involved in a neurogenic mechanism of HBO2-induced lung injury that is linked to central nervous system oxygen toxicity through adrenergic/cholinergic pathways...
  27. pmc Mice lacking inducible nitric oxide synthase demonstrate impaired killing of Porphyromonas gingivalis
    Robert Gyurko
    Department of Periodontology and Oral Biology, Goldman School of Dental Medicine, Boston University, Massachusetts 02118, USA
    Infect Immun 71:4917-24. 2003
    ..gingivalis. These results indicate that modulation of superoxide levels is a mechanism by which NO influences PMN function and that NO is an important element of the host defense against P. gingivalis...
  28. ncbi request reprint Lack of nitric oxide synthase depresses ion transporting enzyme function in cardiac muscle
    Lan Zhou
    Department of Medicine, Division of Cardiology, The Johns Hopkins University School of Medicine, Baltimore, USA
    Biochem Biophys Res Commun 294:1030-5. 2002
    ....
  29. ncbi request reprint Long-term treatment with N(omega)-nitro-L-arginine methyl ester causes arteriosclerotic coronary lesions in endothelial nitric oxide synthase-deficient mice
    Osamu Suda
    Second Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Circulation 106:1729-35. 2002
    ..We addressed this point in mice that are deficient in the endothelial NO synthase gene (eNOS-KO mice)...
  30. ncbi request reprint Vasculoprotective roles of neuronal nitric oxide synthase
    Tsuyoshi Morishita
    Second Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine, Kitakyushu, Japan
    FASEB J 16:1994-6. 2002
    ..These results provide the first direct evidence that nNOS plays important roles in suppressing arteriosclerotic vascular lesion formation in vivo...
  31. ncbi request reprint [Mice lacking the eNOS gene]
    Masao Moroi
    Division of Cardiovascular Medicine, Toho University School of Medicine, Ohashi Hospital
    Nihon Rinsho 62:469-73. 2004
  32. ncbi request reprint Oxygen seizure latency and peroxynitrite formation in mice lacking neuronal or endothelial nitric oxide synthases
    Ivan T Demchenko
    Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St Petersburg, 194223, Russia
    Neurosci Lett 344:53-6. 2003
    ....
  33. ncbi request reprint Nitric oxide protects cardiac sarcolemmal membrane enzyme function and ion active transport against ischemia-induced inactivation
    Kai Y Xu
    Department of Medicine, Division of Cardiology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21224, USA
    J Biol Chem 278:41798-803. 2003
    ..These novel findings indicate that NO. can protect cardiac SL NOSs and (Na+ + K+)-ATPase against ischemia-induced inactivation and suggest that locally generated NO. may serve to regulate SL Na+/K+ ion active transport in the heart...
  34. ncbi request reprint Noncholinergic penile erection in mice lacking the gene for endothelial nitric oxide synthase
    Arthur L Burnett
    Department of Urology, The James Buchanan Brady Urological Institute, The Johns Hopkins Hospital and The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 2411, USA
    J Androl 23:92-7. 2002
    ..We concluded that eNOS-/- mice preserve erectile function on the basis of a noncholinergic but NO-dependent mechanism and that eNOS physiologically mediates penile erection under cholinergic stimulation...

Research Grants34

  1. NITRIC OXIDE SYNTHASE ISOFORMS IN ATHEROSCLEROSIS
    Paul Huang; Fiscal Year: 2006
    ..We propose to use bone marrow transplantation studies to assess the importance of NOS isoform expression by bone marrow-derived cells to vessel injury and atherosclerosis in vivo. ..
  2. Nitric Oxide and Mechanisms of Neuroprotection
    Paul Huang; Fiscal Year: 2006
    ..3. Test the hypothesis that Akt activation mediates neuroprotection in ischemic preconditioning and in global ischemia. ..
  3. ATHEROSCLEROSIS AND CEREBRAL ISCHEMIA
    Paul Huang; Fiscal Year: 2007
    ..They also provide proof of principle for approaches that directly target cerebral vascular dysfunction for the treatment and prevention of stroke. ..
  4. eNOS phosphorylation in cerebrovascular function and stroke
    Paul L Huang; Fiscal Year: 2010
    ..This may well lead to the development of new treatment options directly addressing the links between metabolic diseases and (cerebro)vascular disease. ..
  5. NITRIC OXIDE SYNTHASE ISOFORMS IN ATHEROSCLEROSIS
    Paul Huang; Fiscal Year: 2003
    ..We propose to use bone marrow transplantation studies to assess the importance of NOS isoform expression by bone marrow-derived cells to vessel injury and atherosclerosis in vivo. ..
  6. NOS ISOFORMS IN CEREBRAL BLOOD FLOW
    Paul Huang; Fiscal Year: 2001
    ....
  7. NITRIC OXIDE SYNTHASE ISOFORMS IN ATHEROSCLEROSIS
    Paul Huang; Fiscal Year: 2002
    ....
  8. eNOS phosphorylation in cerebrovascular function and stroke
    Paul Huang; Fiscal Year: 2009
    ..This may well lead to the development of new treatment options directly addressing the links between metabolic diseases and (cerebro)vascular disease. ..