Jason L Hornick

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi request reprint Clinicopathologic and immunohistochemical study of small apparently "de novo" colorectal adenocarcinomas
    Jason L Hornick
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Surg Pathol 31:207-15. 2007
  2. doi request reprint Seasonal variations in the crop contents of scavenging Helmeted Guinea Fowls (Numida meleagris, L.) in Parakou (Benin)
    M Dahouda
    Faculty of Agronomic Science, Department of Animal Production, University of Abomey Calavi, Cotonou, Republic of Benin
    Br Poult Sci 49:751-9. 2008
  3. ncbi request reprint Prevalence and significance of prominent mucin pools in the esophagus post neoadjuvant chemoradiotherapy for Barrett's-associated adenocarcinoma
    Jason L Hornick
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Am J Surg Pathol 30:28-35. 2006
  4. doi request reprint Primary extragastrointestinal stromal tumor of the pleura: report of a unique case with genetic confirmation
    Kevin B Long
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Surg Pathol 34:907-12. 2010
  5. doi request reprint MUC4 is a sensitive and extremely useful marker for sclerosing epithelioid fibrosarcoma: association with FUS gene rearrangement
    Leona A Doyle
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Surg Pathol 36:1444-51. 2012
  6. doi request reprint Mucosal Schwann cell "hamartoma": clinicopathologic study of 26 neural colorectal polyps distinct from neurofibromas and mucosal neuromas
    Joanna A Gibson
    Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Surg Pathol 33:781-7. 2009
  7. ncbi request reprint Extent of low-grade dysplasia is a risk factor for the development of esophageal adenocarcinoma in Barrett's esophagus
    Amitabh Srivastava
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Gastroenterol 102:483-93; quiz 694. 2007
  8. ncbi request reprint Podoplanin (D2-40) is a novel marker for follicular dendritic cell tumors
    Hongbo Yu
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Clin Pathol 128:776-82. 2007
  9. doi request reprint Rhabdomyosarcomatous differentiation in gastrointestinal stromal tumors after tyrosine kinase inhibitor therapy: a novel form of tumor progression
    Bernadette Liegl
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Surg Pathol 33:218-26. 2009
  10. pmc Dedifferentiation in gastrointestinal stromal tumor to an anaplastic KIT-negative phenotype: a diagnostic pitfall: morphologic and molecular characterization of 8 cases occurring either de novo or after imatinib therapy
    Cristina R Antonescu
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Am J Surg Pathol 37:385-92. 2013

Detail Information

Publications111 found, 100 shown here

  1. ncbi request reprint Clinicopathologic and immunohistochemical study of small apparently "de novo" colorectal adenocarcinomas
    Jason L Hornick
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Surg Pathol 31:207-15. 2007
    ....
  2. doi request reprint Seasonal variations in the crop contents of scavenging Helmeted Guinea Fowls (Numida meleagris, L.) in Parakou (Benin)
    M Dahouda
    Faculty of Agronomic Science, Department of Animal Production, University of Abomey Calavi, Cotonou, Republic of Benin
    Br Poult Sci 49:751-9. 2008
    ..4. Scavenging provided insufficient nutrients and energy to allow guinea fowls to be productive. Therefore, more nutritionally balanced supplementary feed would be required during both seasons...
  3. ncbi request reprint Prevalence and significance of prominent mucin pools in the esophagus post neoadjuvant chemoradiotherapy for Barrett's-associated adenocarcinoma
    Jason L Hornick
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Am J Surg Pathol 30:28-35. 2006
    ....
  4. doi request reprint Primary extragastrointestinal stromal tumor of the pleura: report of a unique case with genetic confirmation
    Kevin B Long
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Surg Pathol 34:907-12. 2010
    ..This seems to be the first EGIST arising above the diaphragm. This case shows a potential diagnostic pitfall with therapeutic consequences...
  5. doi request reprint MUC4 is a sensitive and extremely useful marker for sclerosing epithelioid fibrosarcoma: association with FUS gene rearrangement
    Leona A Doyle
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Surg Pathol 36:1444-51. 2012
    ..SEF without MUC4 expression may represent a distinct group of tumors. MUC4 expression correlates with glandular epithelial differentiation in biphasic synovial sarcoma and is very limited in other epithelioid soft tissue tumors...
  6. doi request reprint Mucosal Schwann cell "hamartoma": clinicopathologic study of 26 neural colorectal polyps distinct from neurofibromas and mucosal neuromas
    Joanna A Gibson
    Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Surg Pathol 33:781-7. 2009
    ..Although their nature is uncertain, we propose the interim designation "mucosal Schwann cell 'hamartoma'" to avoid confusion with the neural lesions that have significant associations with inherited syndromes...
  7. ncbi request reprint Extent of low-grade dysplasia is a risk factor for the development of esophageal adenocarcinoma in Barrett's esophagus
    Amitabh Srivastava
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Gastroenterol 102:483-93; quiz 694. 2007
    ..The aim of this discovery study was to evaluate the hypothesis that extent of LGD and HGD are risk factors for progression to EA...
  8. ncbi request reprint Podoplanin (D2-40) is a novel marker for follicular dendritic cell tumors
    Hongbo Yu
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Clin Pathol 128:776-82. 2007
    ..Podoplanin is a highly sensitive marker for FDC tumors and may be useful to help confirm the diagnosis in conjunction with conventional FDC markers, particularly in the differential diagnosis of dendritic cell and histiocytic lesions...
  9. doi request reprint Rhabdomyosarcomatous differentiation in gastrointestinal stromal tumors after tyrosine kinase inhibitor therapy: a novel form of tumor progression
    Bernadette Liegl
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Surg Pathol 33:218-26. 2009
    ..The rhabdomyoblastic differentiation can represent a diagnostic pitfall. The molecular mechanisms for this form of TKI-resistant clonal evolution remain to be determined...
  10. pmc Dedifferentiation in gastrointestinal stromal tumor to an anaplastic KIT-negative phenotype: a diagnostic pitfall: morphologic and molecular characterization of 8 cases occurring either de novo or after imatinib therapy
    Cristina R Antonescu
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Am J Surg Pathol 37:385-92. 2013
    ..This phenomenon is not related to additional KIT mutations, but might be secondary to genetic instability, either represented by loss of heterozygosity or low level of KIT amplification...
  11. doi request reprint Primary cutaneous PEComa: distinctive clear cell lesions of skin
    Bernadette Liegl
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Surg Pathol 32:608-14. 2008
    ..Primary cutaneous PEComas are rare and thus far apparently benign cutaneous tumors. Accurate recognition of this entity is essential because of potential misdiagnosis as malignant tumors, especially malignant melanoma...
  12. ncbi request reprint Smoothelin is a specific marker for smooth muscle neoplasms of the gastrointestinal tract
    Dominique P Coco
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Surg Pathol 33:1795-801. 2009
    ....
  13. doi request reprint Monoclonal antibody DOG1.1 shows higher sensitivity than KIT in the diagnosis of gastrointestinal stromal tumors, including unusual subtypes
    Bernadette Liegl
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Surg Pathol 33:437-46. 2009
    ..DOG1.1 is also a sensitive marker for unusual GIST subgroups lacking KIT or PDGFRA mutations. In tumors that are negative for both KIT and DOG1.1, mutational screening may be required to confirm the diagnosis of GIST...
  14. pmc Combined use of ALK immunohistochemistry and FISH for optimal detection of ALK-rearranged lung adenocarcinomas
    Lynette M Sholl
    Department of Pathology Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    J Thorac Oncol 8:322-8. 2013
    ..Immunohistochemistry (IHC) for ALK protein overexpression is a promising screening modality, with reports of newer antibodies showing excellent sensitivity and specificity for ALK-rearranged lung ACA...
  15. pmc Predictors of lymph node count in colorectal cancer resections: data from US nationwide prospective cohort studies
    Teppei Morikawa
    Department of Medical Oncology, Dana Farber Cancer Institute and Havard Medical School, Boston, MA 02215, USA
    Arch Surg 147:715-23. 2012
    ..To identify factors that influence the total and negative lymph node counts in colorectal cancer resection specimens independent of pathologists and surgeons...
  16. doi request reprint PAX8 Expression in well-differentiated pancreatic endocrine tumors: correlation with clinicopathologic features and comparison with gastrointestinal and pulmonary carcinoid tumors
    Kevin B Long
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Am J Surg Pathol 34:723-9. 2010
    ..PAX8 may also be a prognostic marker in PETs, as loss of expression is associated with malignant behavior...
  17. doi request reprint Dedifferentiated liposarcoma with "homologous" lipoblastic (pleomorphic liposarcoma-like) differentiation: clinicopathologic and molecular analysis of a series suggesting revised diagnostic criteria
    Adrian Mariño-Enríquez
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Surg Pathol 34:1122-31. 2010
    ..The available clinical and molecular data support the notion of "homologous" lipoblastic differentiation in dedifferentiated LPS, rather than mixed-type LPS...
  18. doi request reprint Interobserver variability in the diagnosis of crypt dysplasia in Barrett esophagus
    Dominique P Coco
    Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Surg Pathol 35:45-54. 2011
    ..Long-term and multi-institutional studies should be carried out to further determine the biological and clinical significance and natural history of CD in patients with BE...
  19. doi request reprint Angiosarcoma: a tissue microarray study with diagnostic implications
    Priya Rao
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 4009, USA
    Am J Dermatopathol 35:432-7. 2013
    ..We sought to examine the pattern of immunohistochemical markers of differentiation in AS and correlate these with outcome...
  20. doi request reprint Imaging features of primary and secondary adult rhabdomyosarcoma
    Sachin S Saboo
    Department of Radiology, Dana Farber Cancer Institute, Brigham and Women s Hospital, and Harvard Medical School, 450 Brookline Ave, Boston, MA 02215, USA
    AJR Am J Roentgenol 199:W694-703. 2012
    ..Rhabdomyosarcomas are rare and aggressive soft-tissue sarcomas in adults. The purpose of this article is to describe the imaging features of primary and secondary adult rhabdomyosarcomas utilizing MRI, CT, and (18)F-FDG PET/CT...
  21. pmc Case report: atypical lipomatous tumor with unusual extensive metaplastic ossification
    Omar Javery
    aDepartment of Radiology, Brigham and Womens Hospital, Harvard Medical School, Boston, MA 02215, USA
    Cancer Imaging 12:25-30. 2012
    ..We report a case of ALT/WDLPS with unusual extensive metaplastic bone formation without an element of dedifferentiated liposarcoma...
  22. pmc Sox2 protein expression is an independent poor prognostic indicator in stage I lung adenocarcinoma
    Lynette M Sholl
    Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Surg Pathol 34:1193-8. 2010
    ..5; 95% CI 1.2-5.1), but not in women. Sox2 seems to be an independent predictor of poor outcome in stage I lung adenocarcinomas and may help stratify patients at increased risk for recurrence...
  23. doi request reprint A comprehensive analysis of PAX8 expression in human epithelial tumors
    Anna R Laury
    Department of Pathology, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Am J Surg Pathol 35:816-26. 2011
    ..In a subset of cases, additional markers, including but not limited to thyroid transcription factor-1, RCC, and Wilms tumor-1, may be needed to distinguish between the 3 most common PAX8-positive tumors...
  24. doi request reprint Identification of succinate dehydrogenase-deficient bladder paragangliomas
    Emily F Mason
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School Department of Pathology, Massachusetts General Hospital, Harvard Medical School Dana Farber Cancer Institute, Center for Sarcoma and Bone Oncology, Harvard Medical School, Boston, MA Department of Pathology, The Ottawa Hospital, Ottawa, ON, Canada
    Am J Surg Pathol 37:1612-8. 2013
    ..A significant subset of bladder paragangliomas is SDH deficient. It is essential to identify SDH-deficient tumors, as the presence of an SDH mutation has prognostic implications and is important in guiding genetic counseling. ..
  25. doi request reprint Pleomorphic fibroma and dermal atypical lipomatous tumor: are they related?
    Tariq Al-Zaid
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    J Cutan Pathol 40:379-84. 2013
    ..Therefore, these two entities are best regarded as pathogenetically distinct. MDM2 immunohistochemistry or fluorescence in situ hybridization studies can be used to differentiate between the two if needed...
  26. pmc Epicutaneous sensitization results in IgE-dependent intestinal mast cell expansion and food-induced anaphylaxis
    Lisa M Bartnikas
    Division of Immunology, Boston Children s Hospital, Boston, Mass 02115, USA
    J Allergy Clin Immunol 131:451-60.e1-6. 2013
    ..Sensitization to food antigen can occur through cutaneous exposure...
  27. doi request reprint Loss of succinate dehydrogenase subunit B (SDHB) expression is limited to a distinctive subset of gastric wild-type gastrointestinal stromal tumours: a comprehensive genotype-phenotype correlation study
    Leona A Doyle
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Histopathology 61:801-9. 2012
    ..The aim of this study was to validate the predictive value of SDHB immunohistochemistry in a large genotyped cohort...
  28. doi request reprint Well-differentiated and dedifferentiated liposarcomas with prominent myxoid stroma: analysis of 56 cases
    Stefano Sioletic
    Ludwig Center at Dana Farber Harvard Cancer Center, and Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Histopathology 62:287-93. 2013
    ..The aim of this study was to analyse the clinicopathological and genetic features of well-differentiated/dedifferentiated LPS with prominent myxoid stroma...
  29. doi request reprint Expression of ERG, an Ets family transcription factor, identifies ERG-rearranged Ewing sarcoma
    Wei Lien Wang
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Mod Pathol 25:1378-83. 2012
    ..In contrast, FLI1 was not specific to rearrangement type, likely because of cross reactivity with the highly homologous Ets DNA-binding domain present in the C-terminus of both ERG and FLI1...
  30. doi request reprint Loss of INI1 expression is characteristic of both conventional and proximal-type epithelioid sarcoma
    Jason L Hornick
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Surg Pathol 33:542-50. 2009
    ..Immunostaining for INI1 can be used to confirm the diagnosis of ES in the appropriate context. Loss of INI1 expression may also be helpful to distinguish epithelioid MPNST from metastatic melanoma in a subset of cases...
  31. pmc O6-methylguanine DNA methyltransferase deficiency and response to temozolomide-based therapy in patients with neuroendocrine tumors
    Matthew H Kulke
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Clin Cancer Res 15:338-45. 2009
    ..We evaluated the prevalence of MGMT deficiency in neuroendocrine tumors and correlated MGMT deficiency with treatment response to temozolomide-based regimens...
  32. ncbi request reprint Embryonic stem cell transcription factor signatures in the diagnosis of primary and metastatic germ cell tumors
    Sandro Santagata
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Surg Pathol 31:836-45. 2007
    ....
  33. doi request reprint SOX2 is highly expressed in squamous cell carcinomas of the gastrointestinal tract
    Kevin B Long
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Hum Pathol 40:1768-73. 2009
    ..SOX2 may be useful in an immunohistochemical panel to differentiate between squamous cell carcinomas and adenocarcinomas of the gastrointestinal tract...
  34. doi request reprint Epithelioid inflammatory myofibroblastic sarcoma: An aggressive intra-abdominal variant of inflammatory myofibroblastic tumor with nuclear membrane or perinuclear ALK
    Adrian Mariño-Enríquez
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Am J Surg Pathol 35:135-44. 2011
    ..We propose the designation "epithelioid inflammatory myofibroblastic sarcoma" to convey both the malignant behavior of these tumors and their close relationship with IMT...
  35. pmc Sequence-based discovery of Bradyrhizobium enterica in cord colitis syndrome
    Ami S Bhatt
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, USA
    N Engl J Med 369:517-28. 2013
    ..It has been hypothesized that the cord colitis syndrome, a complication of umbilical-cord hematopoietic stem-cell transplantation, is infectious in origin...
  36. doi request reprint Loss of expression of SDHA predicts SDHA mutations in gastrointestinal stromal tumors
    Andrew J Wagner
    Dana Farber Cancer Institute, Center for Sarcoma and Bone Oncology, Harvard Medical School, Boston, MA, USA
    Mod Pathol 26:289-94. 2013
    ..Immunohistochemistry for SDHA can be used to select patients for SDHA-specific genetic testing...
  37. pmc Cutaneous syncytial myoepithelioma: clinicopathologic characterization in a series of 38 cases
    Vickie Y Jo
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Am J Surg Pathol 37:710-8. 2013
    ..Prior reports describe some risk of recurrence and metastasis for cutaneous myoepithelial tumors; however, the syncytial variant appears to behave in a benign manner and only rarely recurs locally...
  38. doi request reprint Cardiac angiosarcoma management and outcomes: 20-year single-institution experience
    Nicole J Look Hong
    Division of Surgical Oncology, Brigham and Women s Hospital, Center for Sarcoma and Bone Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
    Ann Surg Oncol 19:2707-15. 2012
    ..To identify the clinicopathologic characteristics, treatments, and outcomes of a series of patients with primary cardiac angiosarcoma (AS)...
  39. doi request reprint Sclerosing PEComa: clinicopathologic analysis of a distinctive variant with a predilection for the retroperitoneum
    Jason L Hornick
    Department of Pathology, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02115, USA
    Am J Surg Pathol 32:493-501. 2008
    ..Sclerosing PEComas seem to pursue an indolent clinical course, unless associated with a frankly malignant component. Long-term follow-up will be required to confirm these findings...
  40. doi request reprint Embryonic stem cell transcription factors and D2-40 (podoplanin) as diagnostic immunohistochemical markers in ovarian germ cell tumors
    Martin C Chang
    Department of Pathology, Division of Women s and Perinatal Pathology, Brigham and Women s Hospital, Children s Hospital Boston, Massachusetts 02115, USA
    Int J Gynecol Pathol 28:347-55. 2009
    ..The inclusion of these markers should therefore be considered in cases of pure or mixed ovarian germ cell tumors that are difficult to classify, and to exclude nongerm cell tumor mimics...
  41. doi request reprint Low prevalence of submucosal invasive carcinoma at esophagectomy for high-grade dysplasia or intramucosal adenocarcinoma in Barrett's esophagus: a 20-year experience
    Victor S Wang
    Division of Gastroenterology and Hepatology, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts 02215, USA
    Gastrointest Endosc 69:777-83. 2009
    ..The rate of occult adenocarcinoma at esophagectomy in patients with Barrett's esophagus (BE) and high-grade dysplasia (HGD) has been reported to be approximately 40%. Recently, it has been suggested that this risk may be overestimated...
  42. ncbi request reprint Buried Barrett's epithelium following photodynamic therapy shows reduced crypt proliferation and absence of DNA content abnormalities
    Jason L Hornick
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Am J Gastroenterol 103:38-47. 2008
    ..The neoplastic potential of buried BE is poorly understood. The aim of this study was to evaluate the biological characteristics of nonburied and buried BE in patients treated with PDT...
  43. doi request reprint INI1-deficient tumors: diagnostic features and molecular genetics
    Travis J Hollmann
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Am J Surg Pathol 35:e47-63. 2011
    ..We will review the clinicopathologic features of these tumor types and emphasize the clinical utility of INI1 immunohistochemistry in differential diagnosis...
  44. doi request reprint "Pediatric-type" gastrointestinal stromal tumors in adults: distinctive histology predicts genotype and clinical behavior
    Tanya A Rege
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Am J Surg Pathol 35:495-504. 2011
    ..Although metastases are common and most tumors are imatinib resistant, they pursue a relatively indolent clinical course. Recognition of "pediatric-type" GISTs in adults is critical for prognosis, appropriate therapy, and follow-up...
  45. doi request reprint Predictors of response to targeted therapies for gastrointestinal stromal tumors
    Andrea Marrari
    Center for Sarcoma and Bone Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, USA
    Arch Pathol Lab Med 136:483-9. 2012
    ..These drugs marked a revolution in cancer treatment, not only for their safety and efficacy, but also because they continue to expand our knowledge of the pathophysiology of cancer...
  46. doi request reprint A novel blueprint for 'top down' differentiation defines the cervical squamocolumnar junction during development, reproductive life, and neoplasia
    Michael Herfs
    Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Pathol 229:460-8. 2013
    ..It also provides new targets in animal models to determine why the SC junction is uniquely susceptible to carcinogenic HPV infection...
  47. doi request reprint DOG1 antibody is a highly sensitive and specific marker for gastrointestinal stromal tumors in cytology cell blocks
    Dick G Hwang
    Dept of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Clin Pathol 135:448-53. 2011
    ..KIT was positive in 46 (88%) of the GIST cases, with sensitivity dependent on the FNA method. Both markers were highly specific: KIT was negative in all 44 non-GIST cases, whereas DOG1 showed weak positivity in only 1 leiomyosarcoma...
  48. pmc Imaging features of primary extranodal histiocytic sarcoma: report of two cases and a review of the literature
    Sachin Shyamsunder Saboo
    Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02145, USA
    Cancer Imaging 12:253-8. 2012
    ..We report on the imaging features of two cases of primary histiocytic sarcoma, one in the retroperitoneum causing a tumor-bowel fistula and another with primary bone involvement...
  49. pmc Prognostic significance and molecular associations of tumor growth pattern in colorectal cancer
    Teppei Morikawa
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA, USA
    Ann Surg Oncol 19:1944-53. 2012
    ..However, little is known about the prognostic significance of tumor growth pattern, independent of tumoral molecular alterations and other histologic features...
  50. doi request reprint Outcomes and prognostic factors for a consecutive case series of 115 patients with somatic leiomyosarcoma
    John A Abraham
    Brigham and Women s Hospital, Boston, Massachusetts, USA
    J Bone Joint Surg Am 94:736-44. 2012
    ..The purpose of our study was to further define survival rates as well as to identify multivariable predictors of disease-specific mortality, local recurrence, and development of distant metastasis following surgical resection...
  51. doi request reprint Hybrid schwannoma/perineurioma: clinicopathologic analysis of 42 distinctive benign nerve sheath tumors
    Jason L Hornick
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Am J Surg Pathol 33:1554-61. 2009
    ..Hybrid schwannoma/perineuriomas have no evident association with neurofibromatosis and rarely recur. The pathogenetic basis of the dual pattern of differentiation in these lesions remains poorly understood at this time...
  52. doi request reprint Podoplanin (D2-40) is a highly effective marker of follicular dendritic cells
    Derek K Marsee
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Appl Immunohistochem Mol Morphol 17:102-7. 2009
    ..This study demonstrates that podoplanin is an excellent marker for FDCs and adds to its growing list of diagnostic applications...
  53. doi request reprint PAX8 reliably distinguishes ovarian serous tumors from malignant mesothelioma
    Anna R Laury
    Department of Pathology Section, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Am J Surg Pathol 34:627-35. 2010
    ..The presence of weak staining for PAX8 in the 3 "noninvasive" mesotheliomas questions the use for PAX8 in this differential diagnosis. On the basis of this study, h-caldesmon is not a useful marker for mesothelioma...
  54. doi request reprint Cutaneous and subcutaneous metastases of gastrointestinal stromal tumors: a series of 5 cases with molecular analysis
    Wei Lien Wang
    Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030 4009, USA
    Am J Dermatopathol 31:297-300. 2009
    ..Cutaneous metastases seem to be a late complication of GIST, but their presence does not necessarily herald a rapid demise of the patient...
  55. ncbi request reprint Diffuse membranous immunoreactivity for podoplanin (D2-40) distinguishes primary and metastatic seminomas from other germ cell tumors and metastatic neoplasms
    Hongbo Yu
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Clin Pathol 128:767-75. 2007
    ..Immunodetection of podoplanin may be useful to support seminoma in the differential diagnosis of poorly differentiated epithelioid malignant neoplasms...
  56. pmc Cancer of unknown primary sites: what radiologists need to know and what oncologists want to know
    Kyung Won Kim
    Department of Imaging, Dana Farber Cancer Institute, Harvard Medical School, 450 Brookline Ave, Boston, MA 02215, USA
    AJR Am J Roentgenol 200:484-92. 2013
    ..In this article, we review the role of imaging in cancer of unknown primary site (CUP) diagnosis and management and the utility of immunohistochemistry, serum tumor markers, and molecular profiling in the optimized care of CUP patients...
  57. doi request reprint MRI for evaluation of myeloid sarcoma in adults: a single-institution 10-year experience
    Atul B Shinagare
    Department of Imaging, Dana Farber Cancer Institute, 450 Brookline Ave, Boston, MA 02215, USA
    AJR Am J Roentgenol 199:1193-8. 2012
    ..The purpose of this study was to evaluate the utilization and role of MRI in the management of myeloid sarcoma in adults...
  58. doi request reprint Succinate dehydrogenase-deficient tumors: diagnostic advances and clinical implications
    Justine A Barletta
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Adv Anat Pathol 19:193-203. 2012
    ..This review will outline the genetics of SDH-deficient tumors, discuss possible mechanisms of tumorigenesis, and describe how these tumors can be identified by immunohistochemistry...
  59. ncbi request reprint CD25 expression on cutaneous mast cells from adult patients presenting with urticaria pigmentosa is predictive of systemic mastocytosis
    Travis J Hollmann
    Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Surg Pathol 32:139-45. 2008
    ..001). Our findings suggest that immunoreactivity for CD25 in cutaneous mast cells may be useful for stratifying adult patients presenting with UP for additional clinical evaluation...
  60. doi request reprint A comparison of equivocal immunohistochemical results with anti-HER2/neu antibodies A0485 and SP3 with corresponding FISH results in routine clinical practice
    Elizabeth Manion
    Dept of Pathology, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    Am J Clin Pathol 135:845-51. 2011
    ..Compared with A0485, the false-negative rate with SP3 is only 0.3% (3/1,156) higher, but it shows about a 50% reduction in equivocal scores, reducing the need for reflex FISH testing...
  61. ncbi request reprint The role of KIT in the management of patients with gastrointestinal stromal tumors
    Jason L Hornick
    Department of Pathology, Brigham and Women s Hospital Boston, MA 02115, USA
    Hum Pathol 38:679-87. 2007
    ..This review examines the role of KIT in the diagnosis and management of patients with GIST...
  62. doi request reprint Hybrid myxoinflammatory fibroblastic sarcoma/hemosiderotic fibrolipomatous tumor: report of a case providing further evidence for a pathogenetic link
    Christopher P Elco
    Department of Pathology, Brigham and Women s Hospital, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Am J Surg Pathol 34:1723-7. 2010
    ..This hybrid lesion provides further evidence for a close relationship between these 2 tumor types...
  63. ncbi request reprint Immunohistochemistry can help distinguish metastatic pancreatic adenocarcinomas from bile duct adenomas and hamartomas of the liver
    Jason L Hornick
    Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Surg Pathol 29:381-9. 2005
    ..Although p63 and AMACR are also specific for pancreatic adenocarcinoma, their low sensitivity limits their use in clinical practice...
  64. ncbi request reprint Gardner fibroma: a clinicopathologic and immunohistochemical analysis of 45 patients with 57 fibromas
    Cheryl M Coffin
    Department of Pathology, Primary Children s Medical Center and University of Utah School of Medicine, Salt Lake City, Utah, USA
    Am J Surg Pathol 31:410-6. 2007
    ..The proportion of sporadic GAFs that have APC mutation remains to be determined...
  65. ncbi request reprint Neoplastic precursor lesions in Barrett's esophagus
    Jason L Hornick
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Gastroenterol Clin North Am 36:775-96, v. 2007
    ..This article focuses on dysplasia in Barrett's esophagus in terms of its classification, pathologic diagnostic criteria, limitations, natural history, and treatment...
  66. ncbi request reprint Inflammatory myofibroblastic tumor: comparison of clinicopathologic, histologic, and immunohistochemical features including ALK expression in atypical and aggressive cases
    Cheryl M Coffin
    Department of Pathology, Division of Pediatric Pathology, University of Utah School of Medicine, Primary Children s Medical Center, Salt Lake City, UT 84113, USA
    Am J Surg Pathol 31:509-20. 2007
    ..Other proliferative, apoptotic, and prognostic markers did not correlate well with morphology or outcome. Thus, ALK reactivity may be a favorable prognostic indicator in IMT and abdominopelvic IMTs recur more frequently...
  67. doi request reprint Sox2 expression in pulmonary non-small cell and neuroendocrine carcinomas
    Lynette M Sholl
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Appl Immunohistochem Mol Morphol 18:55-61. 2010
    ..0004). Sox2 is highly expressed in concert with p63 in most SCC, but may also influence tumor differentiation in both non-small cell lung carcinomas and pulmonary neuroendocrine tumors...
  68. doi request reprint Loss of retinoblastoma protein expression in spindle cell/pleomorphic lipomas and cytogenetically related tumors: an immunohistochemical study with diagnostic implications
    Benjamin J Chen
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Surg Pathol 36:1119-28. 2012
    ..Rb expression is intact in histologic mimics. These findings reinforce the pathogenetic relationship among this group of tumors and demonstrate the potential diagnostic utility of immunohistochemistry for Rb...
  69. doi request reprint Synovial sarcoma: imaging features of common and uncommon primary sites, metastatic patterns, and treatment response
    Amit Bakri
    Department of Imaging, Dana Farber Cancer Institute, 450 Brookline Ave, Boston, MA 02115, USA
    AJR Am J Roentgenol 199:W208-15. 2012
    ..The purpose of this review is to describe the imaging features, common and uncommon sites, metastatic pattern, and treatment response of synovial sarcoma...
  70. ncbi request reprint Cellular neurothekeoma: detailed characterization in a series of 133 cases
    Jason L Hornick
    Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Surg Pathol 31:329-40. 2007
    ..Atypical histologic features (including pleomorphism, infiltration of subcutis, and a high mitotic rate) seem to have no clinical significance...
  71. pmc Relationship of CDX2 loss with molecular features and prognosis in colorectal cancer
    Yoshifumi Baba
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, USA
    Clin Cancer Res 15:4665-73. 2009
    ....
  72. doi request reprint MUC4 is a highly sensitive and specific marker for low-grade fibromyxoid sarcoma
    Leona A Doyle
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Am J Surg Pathol 35:733-41. 2011
    ..In conclusion, MUC4 is a highly sensitive and quite specific immunohistochemical marker for LGFMS, and can be helpful to distinguish this tumor type from histologic mimics...
  73. doi request reprint "Null pattern" of immunoreactivity in a Lynch syndrome-associated colon cancer due to germline MSH2 mutation and somatic MLH1 hypermethylation
    Catherine E Hagen
    Department of Pathology, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
    Am J Surg Pathol 35:1902-5. 2011
    ..The lack of immunostaining for any of the 4 DNA mismatch repair proteins in this extremely unusual case was, therefore, related to a germline MSH2 mutation and somatic MLH1 promoter hypermethylation...
  74. ncbi request reprint The clinical significance of right-sided colonic inflammation in patients with left-sided chronic ulcerative colitis
    Muthoka L Mutinga
    Brigham and Women s Hospital, Boston University Medical Center, and Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Inflamm Bowel Dis 10:215-9. 2004
    ....
  75. pmc Crizotinib in ALK-rearranged inflammatory myofibroblastic tumor
    James E Butrynski
    Dana Farber Cancer Institute, Boston, MA 02115, USA
    N Engl J Med 363:1727-33. 2010
    ..Funded by Pfizer and others; ClinicalTrials.gov number, NCT00585195.)...
  76. doi request reprint Merkel cell carcinoma: lack of KIT positivity and implications for the use of imatinib mesylate
    Qinghong Yang
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Appl Immunohistochem Mol Morphol 17:276-81. 2009
    ..Indeed, our review of the literature and the apparent lack of efficacy of imatinib mesylate for MCC in a recent phase 2 trial suggest a minor role for KIT signaling in MCC tumorigenesis...
  77. ncbi request reprint Leiomyosarcoma of the inferior vena cava: survival after aggressive management
    Hiromichi Ito
    Department of Surgery, Brigham and Women s Hospital, Dana Farber Cancer Institute, and Harvard Medical School, Boston, MA, USA
    Ann Surg Oncol 14:3534-41. 2007
    ..Leiomyosarcoma (LMS) of the inferior vena cava (IVC) is exceedingly rare. The role of adjuvant therapy remains undefined. This study evaluated outcomes after aggressive management...
  78. pmc Defects in succinate dehydrogenase in gastrointestinal stromal tumors lacking KIT and PDGFRA mutations
    Katherine A Janeway
    Department of Pediatric Hematology Oncology, Dana Farber Cancer Institute and Children s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 108:314-8. 2011
    ..Testing for germline mutations in SDH is recommended in patients with WT GIST. These findings highlight a potential central role of SDH dysregulation in WT GIST oncogenesis...
  79. doi request reprint Mast cell activation syndrome: a newly recognized disorder with systemic clinical manifestations
    Matthew J Hamilton
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Allergy Clin Immunol 128:147-152.e2. 2011
    ..Diagnostic criteria for mast cell (MC) activation syndrome have been recently proposed, but clinical studies to validate these criteria are lacking...
  80. ncbi request reprint Biologic properties of columnar epithelium underneath reepithelialized squamous mucosa in Barrett's esophagus
    Jason L Hornick
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Surg Pathol 29:372-80. 2005
    ..Prospective studies of large numbers of patients with BUSI will be required to determine the magnitude of its risk of progression to cancer...
  81. ncbi request reprint Current management of metastatic gastrointestinal stromal tumor: a case report
    Suzanne George
    Dana Farber Cancer Institute, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Clin Adv Hematol Oncol 1:63-4; discussion 65. 2003
  82. doi request reprint Malignant gastrointestinal neuroectodermal tumor: clinicopathologic, immunohistochemical, ultrastructural, and molecular analysis of 16 cases with a reappraisal of clear cell sarcoma-like tumors of the gastrointestinal tract
    David L Stockman
    Department of Pathology, The Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Am J Surg Pathol 36:857-68. 2012
    ..The designation "malignant gastrointestinal neuroectodermal tumor" is proposed for this tumor type...
  83. doi request reprint Extraskeletal osteosarcoma: spectrum of imaging findings
    Grainne Mc Auley
    Department of Radiology, Dana Farber Cancer Institute, Harvard Medical School, and Department of Pathology, Brigham and Women s Hospital, 450 Brookline Ave, Boston, MA 02215 5450, USA
    AJR Am J Roentgenol 198:W31-7. 2012
    ..The purpose of this article is to present the spectrum of imaging findings of primary and metastatic extraskeletal osteosarcoma and highlight the differences from primary osteogenic osteosarcoma in bone...
  84. pmc A novel, highly sensitive antibody allows for the routine detection of ALK-rearranged lung adenocarcinomas by standard immunohistochemistry
    Mari Mino-Kenudson
    Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts
    Clin Cancer Res 16:1561-71. 2010
    ..In the present study, we used novel antibodies to compare ALK protein expression in genetically defined lung cancers and anaplastic large cell lymphomas...
  85. ncbi request reprint Intestinal perineuriomas: clinicopathologic definition of a new anatomic subset in a series of 10 cases
    Jason L Hornick
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Surg Pathol 29:859-65. 2005
    ..Distinguishing perineuriomas from other spindle cell neoplasms of the gastrointestinal tract can be facilitated by immunostaining for EMA and claudin-1...
  86. ncbi request reprint Immunoreactivity for CD25 in gastrointestinal mucosal mast cells is specific for systemic mastocytosis
    Hejin P Hahn
    Department of Pathology, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02115, USA
    Am J Surg Pathol 31:1669-76. 2007
    ..Aggregates or sheets of mast cells are only seen in SM. Immunoreactivity for CD25 in GI mucosal mast cells is specific for SM and can be used to confirm the diagnosis...
  87. ncbi request reprint Long-term follow-up after polypectomy treatment for adenoma-like dysplastic lesions in ulcerative colitis
    Robert D Odze
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Clin Gastroenterol Hepatol 2:534-41. 2004
    ..The purpose of this study was to evaluate the long-term outcome of our previously defined group of UC patients, all with adenoma-like DALMs, who were treated by polypectomy...
  88. doi request reprint A comparison of estrogen receptor SP1 and 1D5 monoclonal antibodies in routine clinical use reveals similar staining results
    Jane E Brock
    Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Clin Pathol 132:396-401. 2009
    ..Although SP1 is our preferred antibody, with more intense nuclear staining, both MAbs give similar results in tissue from routine clinical samples with discrepant results in fewer than 0.5% of cases...
  89. doi request reprint DNA repair enzyme expression and differential response to temozolomide in a patient with both glioblastoma and metastatic pancreatic neuroendocrine tumor
    Lynn Kristin Bracht
    Center for Neuro Oncology, Boston, MA, USA
    J Clin Oncol 26:4843-4. 2008
  90. ncbi request reprint Spindle cell (sarcomatoid) carcinoma of the breast: a clinicopathologic and immunohistochemical analysis of 29 cases
    Mark R Carter
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Surg Pathol 30:300-9. 2006
    ..Purely spindled/sarcomatoid tumors have a significantly lower rate of nodal metastases than conventional ductal and lobular breast carcinomas...
  91. doi request reprint Immunohistochemical staining of thyroidectomy specimens for PTEN can aid in the identification of patients with Cowden syndrome
    Justine A Barletta
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Am J Surg Pathol 35:1505-11. 2011
    ..3%, respectively. In summary, loss of PTEN expression in adenomatous thyroid nodules, whether in all nodules or in a subset of nodules, appears to be both sensitive and specific for CS...
  92. doi request reprint Immunohistochemical staining for TLE1 distinguishes synovial sarcoma from histologic mimics
    Wai Chin Foo
    Dept of Pathology, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    Am J Clin Pathol 135:839-44. 2011
    ..In this study, only a small subset of MPNSTs and SFTs showed limited staining for TLE1...
  93. doi request reprint IgG4 plasma cells in inflammatory myofibroblastic tumor: inflammatory marker or pathogenic link?
    Shahrazadb T Saab
    Department of Pathology, Vanderbilt University Medical Center, Nashville, TN 37232 2561, USA
    Mod Pathol 24:606-12. 2011
    ..Therefore, the ratio alone cannot be used as a reliable discriminator between these two entities and other clinical and pathologic features must always be taken into account...
  94. doi request reprint Cord colitis syndrome in cord-blood stem-cell transplantation
    Alex F Herrera
    Department of Medicine, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    N Engl J Med 365:815-24. 2011
    ..After the transplantation and engraftment of hematopoietic stem cells from umbilical-cord blood, we observed a new syndrome of culture-negative, antibiotic-responsive diarrhea not attributable to any known cause...
  95. doi request reprint Pseudomyogenic hemangioendothelioma: a distinctive, often multicentric tumor with indolent behavior
    Jason L Hornick
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Am J Surg Pathol 35:190-201. 2011
    ..Although the precise nosologic status of this tumor type is uncertain, we propose the interim designation "pseudomyogenic hemangioendothelioma."..
  96. pmc The phosphatidylserine receptors, T cell immunoglobulin mucin proteins 3 and 4, are markers of histiocytic sarcoma and other histiocytic and dendritic cell neoplasms
    David M Dorfman
    Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Hum Pathol 41:1486-94. 2010
    ..We conclude that histiocytic and dendritic cell neoplasms consistently express TIM-3 and TIM-4 and that these molecules are new markers of neoplasms derived from histiocytic and dendritic cells...
  97. ncbi request reprint Comparative analysis of germ cell transcription factors in CNS germinoma reveals diagnostic utility of NANOG
    Sandro Santagata
    Department of Pathology, Division of Neuropathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Surg Pathol 30:1613-8. 2006
    ..These findings also suggest a potential biologic role for NANOG in maintenance of CNS germinoma...
  98. ncbi request reprint KIT-negative gastrointestinal stromal tumors: proof of concept and therapeutic implications
    Fabiola Medeiros
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Surg Pathol 28:889-94. 2004
    ..Notably, some KIT-negative GISTs contain imatinib-sensitive KIT or PDGFRA mutations; therefore, patients with KIT-negative GISTs should not, a priori, be denied imatinib therapy...
  99. ncbi request reprint Calcifying fibrous 'pseudotumor': clinicopathologic study of 15 cases and analysis of its relationship to inflammatory myofibroblastic tumor
    Alessandra F Nascimento
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Int J Surg Pathol 10:189-96. 2002
    ..quot; There is no convincing evidence to support an association between CFP and IMT...
  100. ncbi request reprint Myoepithelial tumors of soft tissue: a clinicopathologic and immunohistochemical study of 101 cases with evaluation of prognostic parameters
    Jason L Hornick
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Surg Pathol 27:1183-96. 2003
    ..Although the majority of morphologically benign or low-grade myoepithelial neoplasms of soft tissue behave in a benign fashion, there is an approximate 20% risk for local recurrence...
  101. ncbi request reprint Cutaneous myoepithelioma: a clinicopathologic and immunohistochemical study of 14 cases
    Jason L Hornick
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Hum Pathol 35:14-24. 2004
    ..Whereas most cutaneous myoepitheliomas behave in a benign fashion, there is apparently a significant risk for local recurrence but a low metastatic potential...