Daphne J Holt

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. doi request reprint Subclinical delusional thinking predicts lateral temporal cortex responses during social reflection
    Benjamin K Brent
    149 13th St Charlestown, MA 02129, USA
    Soc Cogn Affect Neurosci 9:273-82. 2014
  2. pmc Failure of neural responses to safety cues in schizophrenia
    Daphne J Holt
    Department of Psychiatry, Massachusetts General Hospital, 149 13th St, Rm 2608, Charlestown, MA 02129, USA
    Arch Gen Psychiatry 69:893-903. 2012
  3. pmc An anterior-to-posterior shift in midline cortical activity in schizophrenia during self-reflection
    Daphne J Holt
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    Biol Psychiatry 69:415-23. 2011
  4. pmc Dysfunction of a cortical midline network during emotional appraisals in schizophrenia
    Daphne J Holt
    Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA, USA
    Schizophr Bull 37:164-76. 2011
  5. pmc Extinction memory is impaired in schizophrenia
    Daphne J Holt
    Psychiatric Neuroimaging Research Program, Psychiatry Department, Massachusetts General Hospital, Boston, Massachusetts 02129, USA
    Biol Psychiatry 65:455-63. 2009
  6. pmc Neurophysiological correlates of comprehending emotional meaning in context
    Daphne J Holt
    Massachusetts General Hospital, Boston, MA, USA
    J Cogn Neurosci 21:2245-62. 2009
  7. pmc "My Face Is My Fate": biological and psychosocial approaches to the treatment of a woman with obsessions and delusions
    Daphne J Holt
    Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Harv Rev Psychiatry 11:142-54. 2003
  8. ncbi request reprint Sustained activation of the hippocampus in response to fearful faces in schizophrenia
    Daphne J Holt
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Biol Psychiatry 57:1011-9. 2005
  9. ncbi request reprint Reduced density of cholinergic interneurons in the ventral striatum in schizophrenia: an in situ hybridization study
    Daphne J Holt
    Department of Psychiatry, Massachusetts General Hospital East, Room 2625, 149 13th Street, Charlestown, MA 02129, USA
    Biol Psychiatry 58:408-16. 2005
  10. ncbi request reprint The misattribution of salience in delusional patients with schizophrenia
    Daphne J Holt
    Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02129, United States
    Schizophr Res 83:247-56. 2006

Detail Information

Publications25

  1. doi request reprint Subclinical delusional thinking predicts lateral temporal cortex responses during social reflection
    Benjamin K Brent
    149 13th St Charlestown, MA 02129, USA
    Soc Cogn Affect Neurosci 9:273-82. 2014
    ..Thus, delusional thinking in the general population may be associated with reduced activity and aberrant functional connectivity of cortical areas involved in SR. ..
  2. pmc Failure of neural responses to safety cues in schizophrenia
    Daphne J Holt
    Department of Psychiatry, Massachusetts General Hospital, 149 13th St, Rm 2608, Charlestown, MA 02129, USA
    Arch Gen Psychiatry 69:893-903. 2012
    ..In future studies, abnormalities in fear learning and extinction recall may serve as quantitative phenotypes that can be linked to genetic, symptom, or outcome profiles in schizophrenia and those at risk for the disorder...
  3. pmc An anterior-to-posterior shift in midline cortical activity in schizophrenia during self-reflection
    Daphne J Holt
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    Biol Psychiatry 69:415-23. 2011
    ....
  4. pmc Dysfunction of a cortical midline network during emotional appraisals in schizophrenia
    Daphne J Holt
    Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA, USA
    Schizophr Bull 37:164-76. 2011
    ..These findings suggest that impaired functioning of cortical midline structures in schizophrenia may underlie faulty interpretations of social events, contributing to delusion formation...
  5. pmc Extinction memory is impaired in schizophrenia
    Daphne J Holt
    Psychiatric Neuroimaging Research Program, Psychiatry Department, Massachusetts General Hospital, Boston, Massachusetts 02129, USA
    Biol Psychiatry 65:455-63. 2009
    ..To investigate this possibility, we measured the acquisition and extinction of conditioned fear responses and delayed recall of extinction in schizophrenia and control subjects...
  6. pmc Neurophysiological correlates of comprehending emotional meaning in context
    Daphne J Holt
    Massachusetts General Hospital, Boston, MA, USA
    J Cogn Neurosci 21:2245-62. 2009
    ..negative) of words. Thus, emotional processing networks within the brain appear to exert a continuous influence, evident at several stages, on the construction of the emotional meaning of language...
  7. pmc "My Face Is My Fate": biological and psychosocial approaches to the treatment of a woman with obsessions and delusions
    Daphne J Holt
    Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Harv Rev Psychiatry 11:142-54. 2003
  8. ncbi request reprint Sustained activation of the hippocampus in response to fearful faces in schizophrenia
    Daphne J Holt
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Biol Psychiatry 57:1011-9. 2005
    ..Using functional magnetic resonance imaging (fMRI), we tested the hypothesis that habituation of the medial temporal lobe is reduced in schizophrenia...
  9. ncbi request reprint Reduced density of cholinergic interneurons in the ventral striatum in schizophrenia: an in situ hybridization study
    Daphne J Holt
    Department of Psychiatry, Massachusetts General Hospital East, Room 2625, 149 13th Street, Charlestown, MA 02129, USA
    Biol Psychiatry 58:408-16. 2005
    ..In a previous postmortem study, we found a reduction in the density of striatal interneurons that stain immunohistochemically for choline acetyltransferase (ChAT) in schizophrenia...
  10. ncbi request reprint The misattribution of salience in delusional patients with schizophrenia
    Daphne J Holt
    Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02129, United States
    Schizophr Res 83:247-56. 2006
    ..In this study, we tested the hypothesis that delusional schizophrenia patients are more likely than non-delusional schizophrenia patients and healthy participants to assign affective meanings to neutral stimuli...
  11. ncbi request reprint Increased medial temporal lobe activation during the passive viewing of emotional and neutral facial expressions in schizophrenia
    Daphne J Holt
    Massachusetts General Hospital, Department of Psychiatry, Harvard Medical School, Boston, MA 02129, USA
    Schizophr Res 82:153-62. 2006
    ..Here we tested whether MTL responses to human faces in schizophrenia are abnormal when unconstrained by a cognitive task and measured relative to a low-level baseline (fixation) condition...
  12. pmc Lack of insula reactivity to aversive stimuli in schizophrenia
    Clas Linnman
    Department of Anesthesiology, Perioperative and Pain Medicine, Boston Children s Hospital, Harvard Medical School, MA 02114, USA
    Schizophr Res 143:150-7. 2013
    ..These findings provide support for the existence of a basic deficit in interoceptive perception in schizophrenia, which could play a role in the generation and/or maintenance of psychotic states...
  13. ncbi request reprint Increased temporal and prefrontal activity in response to semantic associations in schizophrenia
    Gina R Kuperberg
    Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA
    Arch Gen Psychiatry 64:138-51. 2007
    ..Loosening of associations has long been considered a core feature of schizophrenia, but its neural correlate remains poorly understood...
  14. pmc Association of a polymorphism near CREB1 with differential aversion processing in the insula of healthy participants
    Roy H Perlis
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Arch Gen Psychiatry 65:882-92. 2008
    ....
  15. pmc fMRI analysis of contrast polarity in face-selective cortex in humans and monkeys
    Xiaomin Yue
    Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Neuroimage 76:57-69. 2013
    ..Thus common cortical mechanisms may underlie facial contrast processing across ~25 million years of primate evolution...
  16. doi request reprint Test-retest reliability during fear acquisition and fear extinction in humans
    Mohamed A Zeidan
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    CNS Neurosci Ther 18:313-7. 2012
    ..We, therefore, sought to test the within-subject reliability of a previously used 2-day, classical fear conditioning and extinction paradigm...
  17. doi request reprint Neural correlates of personal space intrusion
    Daphne J Holt
    Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, Harvard Medical School, Boston, Massachusetts 02115, Athinoula A Martinos Center for Biomedical Imaging, Charlestown, Massachusetts 02129, Department of Psychology, Brandeis University, Waltham, Massachusetts 02453, National Institute of Mental Health, Bethesda, Maryland 20892, McLean Hospital, Belmont, Massachusetts 02478, and Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts 02114
    J Neurosci 34:4123-34. 2014
    ..In addition, the magnitude of DIPS and PMv responses was correlated with the preferred level of social activity. Together, these findings suggest that this parietal-frontal network plays a role in everyday interactions with others. ..
  18. ncbi request reprint The evaluation and management of patients with first-episode schizophrenia: a selective, clinical review of diagnosis, treatment, and prognosis
    Oliver Freudenreich
    The Department of Psychiatry, Harvard Medical School, Schizophrenia Program, Massachusetts General Hospital, Boston, MA 02114, USA
    Harv Rev Psychiatry 15:189-211. 2007
    ..We describe the illness course and the prognosis for this acute phase of illness and the immediate, postpsychotic period...
  19. pmc Factors that distinguish college students with depressive symptoms with and without suicidal thoughts
    Maren Nyer
    Depression Clinical and Research Program, Massachusetts General Hospital, Boston, USA
    Ann Clin Psychiatry 25:41-9. 2013
    ..The primary aim of this study was to determine potential factors that may distinguish college students with depressive symptoms with and without SI...
  20. pmc Lower-level stimulus features strongly influence responses in the fusiform face area
    Xiaomin Yue
    Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Cereb Cortex 21:35-47. 2011
    ..Altogether, these results emphasize that a significant portion of the FFA response reflects lower-level visual responses...
  21. doi request reprint Incentive salience: novel treatment strategies for major depression
    David P Soskin
    1 Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA
    CNS Spectr 18:307-14. 2013
    ..Specifically, it provides a rationale for combining behaviorally activating psychotherapies and pro-dopaminergic agents to target impaired reward processing in MDD. ..
  22. pmc Self-disturbances as a possible premorbid indicator of schizophrenia risk: a neurodevelopmental perspective
    Benjamin K Brent
    Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA Massachusetts Mental Health Center Division of Public Psychiatry, Boston, MA, USA Harvard Medical School, Boston, MA, USA Electronic address
    Schizophr Res 152:73-80. 2014
    ..Our goal is that the ideas presented here might provide future directions for research into the neurobiology of SDs during the pre-psychosis development of youth at risk for schizophrenia. ..
  23. pmc The COMT Val108/158Met polymorphism and medial temporal lobe volumetry in patients with schizophrenia and healthy adults
    Stefan Ehrlich
    MGH MIT HMS Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129 2000, USA
    Neuroimage 53:992-1000. 2010
    ..Taken together with previous work, our data support a model in which lower COMT activity, and a resulting elevation in extracellular dopamine levels, stimulates growth of medial temporal lobe structures...
  24. pmc Sex differences in the neurobiology of fear conditioning and extinction: a preliminary fMRI study of shared sex differences with stress-arousal circuitry
    Kelimer Lebron-Milad
    Department of Psychiatry, Harvard Medical School and Massachusetts General Hospital, 149 13th St, Charlestown, MA, 02129, USA
    Biol Mood Anxiety Disord 2:7. 2012
    ..abstract:..
  25. doi request reprint Depression and suicidal ideation in college students
    Amy Farabaugh
    Depression Clinical and Research Program, Massachusetts General Hospital, Boston, MA 02114, USA
    Psychopathology 45:228-34. 2012
    ..Suicide is one of the leading causes of death in college students and is often associated with depression. The aim of this study was to assess the rates of suicidal ideation (SI) on college campuses and to identify its correlates...

Research Grants2

  1. The Neural Basis of Delusions in Schizophrenia: Studies of Emotional Perception
    Daphne Holt; Fiscal Year: 2007
    ..Such early detection methods would provide critical tools for the design of treatment interventions aimed at reducing the severity or preventing the onset of schizophrenia and other psychotic disorders. ..