Research Topics
Species | Daphne J HoltSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
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Publications
Failure of neural responses to safety cues in schizophreniaDaphne J Holt
Department of Psychiatry, Massachusetts General Hospital, 149 13th St, Rm 2608, Charlestown, MA 02129, USA
Arch Gen Psychiatry 69:893-903. 2012..In future studies, abnormalities in fear learning and extinction recall may serve as quantitative phenotypes that can be linked to genetic, symptom, or outcome profiles in schizophrenia and those at risk for the disorder...
"My Face Is My Fate": biological and psychosocial approaches to the treatment of a woman with obsessions and delusionsDaphne J Holt
Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Charlestown, MA 02129, USA
Harv Rev Psychiatry 11:142-54. 2003- An anterior-to-posterior shift in midline cortical activity in schizophrenia during self-reflectionDaphne J Holt
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
Biol Psychiatry 69:415-23. 2011.... - Dysfunction of a cortical midline network during emotional appraisals in schizophreniaDaphne J Holt
Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA, USA
Schizophr Bull 37:164-76. 2011..These findings suggest that impaired functioning of cortical midline structures in schizophrenia may underlie faulty interpretations of social events, contributing to delusion formation... - Extinction memory is impaired in schizophreniaDaphne J Holt
Psychiatric Neuroimaging Research Program, Psychiatry Department, Massachusetts General Hospital, Boston, Massachusetts 02129, USA
Biol Psychiatry 65:455-63. 2009..To investigate this possibility, we measured the acquisition and extinction of conditioned fear responses and delayed recall of extinction in schizophrenia and control subjects... - Neurophysiological correlates of comprehending emotional meaning in contextDaphne J Holt
Massachusetts General Hospital, Boston, MA, USA
J Cogn Neurosci 21:2245-62. 2009..negative) of words. Thus, emotional processing networks within the brain appear to exert a continuous influence, evident at several stages, on the construction of the emotional meaning of language... 
Reduced density of cholinergic interneurons in the ventral striatum in schizophrenia: an in situ hybridization studyDaphne J Holt
Department of Psychiatry, Massachusetts General Hospital East, Room 2625, 149 13th Street, Charlestown, MA 02129, USA
Biol Psychiatry 58:408-16. 2005..In a previous postmortem study, we found a reduction in the density of striatal interneurons that stain immunohistochemically for choline acetyltransferase (ChAT) in schizophrenia...- The misattribution of salience in delusional patients with schizophreniaDaphne J Holt
Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02129, United States
Schizophr Res 83:247-56. 2006..In this study, we tested the hypothesis that delusional schizophrenia patients are more likely than non-delusional schizophrenia patients and healthy participants to assign affective meanings to neutral stimuli... - Increased medial temporal lobe activation during the passive viewing of emotional and neutral facial expressions in schizophreniaDaphne J Holt
Massachusetts General Hospital, Department of Psychiatry, Harvard Medical School, Boston, MA 02129, USA
Schizophr Res 82:153-62. 2006..Here we tested whether MTL responses to human faces in schizophrenia are abnormal when unconstrained by a cognitive task and measured relative to a low-level baseline (fixation) condition... - Sustained activation of the hippocampus in response to fearful faces in schizophreniaDaphne J Holt
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
Biol Psychiatry 57:1011-9. 2005..Using functional magnetic resonance imaging (fMRI), we tested the hypothesis that habituation of the medial temporal lobe is reduced in schizophrenia... - Increased temporal and prefrontal activity in response to semantic associations in schizophreniaGina R Kuperberg
Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA
Arch Gen Psychiatry 64:138-51. 2007..Loosening of associations has long been considered a core feature of schizophrenia, but its neural correlate remains poorly understood... - Association of a polymorphism near CREB1 with differential aversion processing in the insula of healthy participantsRoy H Perlis
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Arch Gen Psychiatry 65:882-92. 2008.... - Test-retest reliability during fear acquisition and fear extinction in humansMohamed A Zeidan
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
CNS Neurosci Ther 18:313-7. 2012..We, therefore, sought to test the within-subject reliability of a previously used 2-day, classical fear conditioning and extinction paradigm... - The evaluation and management of patients with first-episode schizophrenia: a selective, clinical review of diagnosis, treatment, and prognosisOliver Freudenreich
The Department of Psychiatry, Harvard Medical School, Schizophrenia Program, Massachusetts General Hospital, Boston, MA 02114, USA
Harv Rev Psychiatry 15:189-211. 2007..We describe the illness course and the prognosis for this acute phase of illness and the immediate, postpsychotic period... - Lower-level stimulus features strongly influence responses in the fusiform face areaXiaomin Yue
Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
Cereb Cortex 21:35-47. 2011..quot; Altogether, these results emphasize that a significant portion of the FFA response reflects lower-level visual responses... - FMRI analysis of contrast polarity in face-selective cortex in humans and monkeysXiaomin Yue
Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA Electronic address
Neuroimage 76:57-69. 2013..Thus common cortical mechanisms may underlie facial contrast processing across ~25million years of primate evolution... - Factors that distinguish college students with depressive symptoms with and without suicidal thoughtsMaren Nyer
Depression Clinical and Research Program, Massachusetts General Hospital, Boston, USA
Ann Clin Psychiatry 25:41-9. 2013..The primary aim of this study was to determine potential factors that may distinguish college students with depressive symptoms with and without SI... - Lack of insula reactivity to aversive stimuli in schizophreniaClas Linnman
Department of Anesthesiology, Perioperative and Pain Medicine, Boston Children s Hospital, Harvard Medical School, MA 02114, USA
Schizophr Res 143:150-7. 2013..These findings provide support for the existence of a basic deficit in interoceptive perception in schizophrenia, which could play a role in the generation and/or maintenance of psychotic states... - The COMT Val108/158Met polymorphism and medial temporal lobe volumetry in patients with schizophrenia and healthy adultsStefan Ehrlich
MGH MIT HMS Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129 2000, USA
Neuroimage 53:992-1000. 2010..Taken together with previous work, our data support a model in which lower COMT activity, and a resulting elevation in extracellular dopamine levels, stimulates growth of medial temporal lobe structures... - Sex differences in the neurobiology of fear conditioning and extinction: a preliminary fMRI study of shared sex differences with stress-arousal circuitryKelimer Lebron-Milad
Department of Psychiatry, Harvard Medical School and Massachusetts General Hospital, 149 13th St, Charlestown, MA, 02129, USA
Biol Mood Anxiety Disord 2:7. 2012..abstract:.. - Depression and suicidal ideation in college studentsAmy Farabaugh
Depression Clinical and Research Program, Massachusetts General Hospital, Boston, MA 02114, USA
Psychopathology 45:228-34. 2012..Suicide is one of the leading causes of death in college students and is often associated with depression. The aim of this study was to assess the rates of suicidal ideation (SI) on college campuses and to identify its correlates...
Research Grants
- The Neural Basis of Delusions in Schizophrenia: Studies of Emotional PerceptionDaphne Holt; Fiscal Year: 2007..Such early detection methods would provide critical tools for the design of treatment interventions aimed at reducing the severity or preventing the onset of schizophrenia and other psychotic disorders. ..