Charles B Holmes
Affiliation: Massachusetts General Hospital
- Review of human immunodeficiency virus type 1-related opportunistic infections in sub-Saharan AfricaCharles B Holmes
Division of Infectious Disease, Partners AIDS Research Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Clin Infect Dis 36:652-62. 2003..Policies regarding the type and timing of opportunistic infection prophylaxis may be region specific and urgently require further study...
- Optimizing treatment for HIV-infected South African women exposed to single-dose nevirapine: balancing efficacy and costCharles B Holmes
Divisions of Infectious Disease and General Medicine, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA
Clin Infect Dis 42:1772-80. 2006..Our objectives were to project the tradeoffs regarding life expectancy, cost, and cost-effectiveness of these ART regimens for NVP-exposed, HIV-infected women in South Africa...
- CD4 decline and incidence of opportunistic infections in Cape Town, South Africa: implications for prophylaxis and treatmentCharles B Holmes
Divisions of Infectious Disease, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
J Acquir Immune Defic Syndr 42:464-9. 2006..To determine the rate of CD4 decline and the incidence of opportunistic infections (OIs) among antiretroviral therapy-naive South African HIV-infected patients and inform timing of OI prophylaxis...
- First-line antiretroviral therapy after single-dose nevirapine exposure in South Africa: a cost-effectiveness analysis of the OCTANE trialAndrea L Ciaranello
Division of Infectious Disease, Massachusetts General Hospital, Boston, 02114, USA
AIDS 25:479-92. 2011..nevirapine-based antiretroviral therapy (ART) among women previously exposed to single-dose nevirapine to prevent mother-to-child HIV transmission. However, lopinavir/ritonavir is 12 times costlier than nevirapine...
- Diagnostic accuracy of a urine lipoarabinomannan test for tuberculosis in hospitalized patients in a High HIV prevalence settingMaunank Shah
Department of Medicine, Johns Hopkins University Center for Tuberculosis Research, Baltimore, MD 21231, USA
J Acquir Immune Defic Syndr 52:145-51. 2009..Effective tuberculosis (TB) control in HIV-prevalent settings is hindered by absence of accurate, rapid TB diagnostic tests. We evaluated the accuracy of a urine lipoarabinomannan (LAM) test for TB diagnosis in South Africa...
- Comparative costs of inpatient care for HIV-infected and uninfected children and adults in Soweto, South AfricaLeena S Thomas
School of Public Health, University of the Witwatersrand, and Gauteng Department of Health, Johannesburg, South Africa
J Acquir Immune Defic Syndr 46:410-6. 2007..HIV/AIDS creates a massive burden of care for health systems. A better understanding of the impact of HIV infection on health care utilization and costs may enable better use of limited resources...
- The safety and efficacy of switching stavudine to tenofovir df in combination with lamivudine and efavirenz in hiv-1-infected patients: three-year follow-up after switching therapyJosé R Valdez Madruga
Centro de Referência e Treinamento DST AIDS, Sao Paulo, Brazil
HIV Clin Trials 8:381-90. 2007..Study 903 is a phase 3 trial with a completed 144-week, double-blind phase comparing tenofovir DF (TDF) with stavudine (d4T), in combination with lamivudine (3TC) and efavirenz (EFV), and an ongoing 336-week open-label extension phase...
- Response to "CD4 cell count natural history and informative censoring in sub-Saharan Africa"Charles B Holmes
J Acquir Immune Defic Syndr 44:491. 2007
- Tenofovir disoproxil fumarate, emtricitabine, and efavirenz compared with zidovudine/lamivudine and efavirenz in treatment-naive patients: 144-week analysisJose R Arribas
Internal Medicine Service, Hospital de La Paz, Madrid, Spain
J Acquir Immune Defic Syndr 47:74-8. 2008..As antiretroviral regimens for the treatment of HIV infection improve, trials providing data on long-term follow-up are increasingly important...
- Impact of HIV-related infections and ART in South AfricaCharles Holmes; Fiscal Year: 2006..He is mentored by two senior investigators with an extremely strong record of mentoring junior investigators and guiding them to become successful physician scientists. ..