Udo Hoffmann

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi ACR Appropriateness Criteria(®) acute nonspecific chest pain-low probability of coronary artery disease
    Udo Hoffmann
    Massachusetts General Hospital, Boston, MA, USA
    J Am Coll Radiol 9:745-50. 2012
  2. ncbi Coronary CT angiography versus standard evaluation in acute chest pain
    Udo Hoffmann
    Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA
    N Engl J Med 367:299-308. 2012
  3. ncbi Correlation of renin angiotensin and aldosterone system activity with subcutaneous and visceral adiposity: the framingham heart study
    Conall M O'Seaghdha
    National Heart, Lung and Blood Institute s Framingham Heart Study, 73 Mt, Wayte Avenue Suite 2, Framingham, MA, USA
    BMC Endocr Disord 12:3. 2012
  4. ncbi Design of the Rule Out Myocardial Ischemia/Infarction Using Computer Assisted Tomography: a multicenter randomized comparative effectiveness trial of cardiac computed tomography versus alternative triage strategies in patients with acute chest pain in the
    Udo Hoffmann
    Cardiac MR PET CT Program, Massachusetts General Hospital, Boston, MA Harvard Medical School, Boston, MA Division of Cardiology, Massachusetts General Hospital, Boston, MA 02114, USA
    Am Heart J 163:330-8, 338.e1. 2012
  5. ncbi Development and reproducibility of a computed tomography-based measurement of renal sinus fat
    Meredith C Foster
    National Heart, Lung, and Blood Institute s Framingham Heart Study, 73 Mt, Wayte Avenue, Suite 2, Framingham, Massachusetts 01702, USA
    BMC Nephrol 12:52. 2011
  6. ncbi Heritability and genome-wide association analysis of renal sinus fat accumulation in the Framingham Heart Study
    Meredith C Foster
    National Heart, Lung, and Blood Institute s Framingham Heart Study, 73 Mt, Wayte Avenue, Suite 2, Framingham, Massachusetts 01702, USA
    BMC Med Genet 12:148. 2011
  7. ncbi Effects of combined low-density lipoprotein apheresis and aggressive statin therapy on coronary calcified plaque as measured by computed tomography
    Udo Hoffmann
    Department of Diagnostic Radiology, University and General Hospital of Vienna, Vienna, Austria
    Am J Cardiol 91:461-4. 2003
  8. ncbi Noninvasive assessment of plaque morphology and composition in culprit and stable lesions in acute coronary syndrome and stable lesions in stable angina by multidetector computed tomography
    Udo Hoffmann
    Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Am Coll Cardiol 47:1655-62. 2006
  9. ncbi Usefulness of magnetic resonance imaging of cardiac and paracardiac masses
    Udo Hoffmann
    Department of Radiology, General Hospital and University of Vienna, Vienna, Austria
    Am J Cardiol 92:890-5. 2003
  10. ncbi Defining normal distributions of coronary artery calcium in women and men (from the Framingham Heart Study)
    Udo Hoffmann
    MGH Cardiac MR PET CT Program and Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Cardiol 102:1136-41, 1141.e1. 2008

Research Grants

  1. Cardiac MDCT for Early Triage of Patients with ACS
    Udo Hoffmann; Fiscal Year: 2006
  2. PROMISE Trial: Dx Core
    Udo Hoffmann; Fiscal Year: 2009
  3. PROMISE Trial: Dx Core
    Udo Hoffmann; Fiscal Year: 2010

Collaborators

Detail Information

Publications133 found, 100 shown here

  1. ncbi ACR Appropriateness Criteria(®) acute nonspecific chest pain-low probability of coronary artery disease
    Udo Hoffmann
    Massachusetts General Hospital, Boston, MA, USA
    J Am Coll Radiol 9:745-50. 2012
    ..In those instances in which evidence is lacking or not definitive, expert opinion may be used to recommend imaging or treatment...
  2. ncbi Coronary CT angiography versus standard evaluation in acute chest pain
    Udo Hoffmann
    Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA
    N Engl J Med 367:299-308. 2012
    ..It is unclear whether an evaluation incorporating coronary computed tomographic angiography (CCTA) is more effective than standard evaluation in the emergency department in patients with symptoms suggestive of acute coronary syndromes...
  3. ncbi Correlation of renin angiotensin and aldosterone system activity with subcutaneous and visceral adiposity: the framingham heart study
    Conall M O'Seaghdha
    National Heart, Lung and Blood Institute s Framingham Heart Study, 73 Mt, Wayte Avenue Suite 2, Framingham, MA, USA
    BMC Endocr Disord 12:3. 2012
    ..abstract:..
  4. ncbi Design of the Rule Out Myocardial Ischemia/Infarction Using Computer Assisted Tomography: a multicenter randomized comparative effectiveness trial of cardiac computed tomography versus alternative triage strategies in patients with acute chest pain in the
    Udo Hoffmann
    Cardiac MR PET CT Program, Massachusetts General Hospital, Boston, MA Harvard Medical School, Boston, MA Division of Cardiology, Massachusetts General Hospital, Boston, MA 02114, USA
    Am Heart J 163:330-8, 338.e1. 2012
    ..The ROMICAT II will provide rigorous data on whether CCTA is more efficient than standard of care in the management of patients with acute chest pain at intermediate risk for acute coronary syndrome...
  5. ncbi Development and reproducibility of a computed tomography-based measurement of renal sinus fat
    Meredith C Foster
    National Heart, Lung, and Blood Institute s Framingham Heart Study, 73 Mt, Wayte Avenue, Suite 2, Framingham, Massachusetts 01702, USA
    BMC Nephrol 12:52. 2011
    ..We sought to develop a protocol to quantify renal sinus fat accumulation using multi-detector computed tomography (MDCT)...
  6. ncbi Heritability and genome-wide association analysis of renal sinus fat accumulation in the Framingham Heart Study
    Meredith C Foster
    National Heart, Lung, and Blood Institute s Framingham Heart Study, 73 Mt, Wayte Avenue, Suite 2, Framingham, Massachusetts 01702, USA
    BMC Med Genet 12:148. 2011
    ..Ectopic fat accumulation in the renal sinus is associated with chronic kidney disease and hypertension. The genetic contributions to renal sinus fat accumulation in humans have not been well characterized...
  7. ncbi Effects of combined low-density lipoprotein apheresis and aggressive statin therapy on coronary calcified plaque as measured by computed tomography
    Udo Hoffmann
    Department of Diagnostic Radiology, University and General Hospital of Vienna, Vienna, Austria
    Am J Cardiol 91:461-4. 2003
  8. ncbi Noninvasive assessment of plaque morphology and composition in culprit and stable lesions in acute coronary syndrome and stable lesions in stable angina by multidetector computed tomography
    Udo Hoffmann
    Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Am Coll Cardiol 47:1655-62. 2006
    ..The purpose of this study was to assess morphology and composition of culprit and stable coronary lesions by multidetector computed tomography (MDCT)...
  9. ncbi Usefulness of magnetic resonance imaging of cardiac and paracardiac masses
    Udo Hoffmann
    Department of Radiology, General Hospital and University of Vienna, Vienna, Austria
    Am J Cardiol 92:890-5. 2003
    ..Observers were accurate in the prediction of lesion type (area under curve 0.88 and 0.92), and there was good interobserver variability (Cohen's kappa = 0.64)...
  10. ncbi Defining normal distributions of coronary artery calcium in women and men (from the Framingham Heart Study)
    Udo Hoffmann
    MGH Cardiac MR PET CT Program and Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Cardiol 102:1136-41, 1141.e1. 2008
    ..Absolute cutoffs underestimated the proportion of subjects with increased CAC, specifically in women, younger persons, and persons at intermediate CHD risk...
  11. ncbi Noninvasive detection of coronary atherosclerotic plaque by multidetector row computed tomography
    U Hoffmann
    Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Int J Obes (Lond) 29:S46-53. 2005
    ..In fact, algorithms such as the Framingham risk score that are based on traditional risk factors like hypertension and dyslipidemia are not very sensitive, leaving a majority of the population at intermediate risk...
  12. ncbi Coronary computed tomography angiography for early triage of patients with acute chest pain: the ROMICAT (Rule Out Myocardial Infarction using Computer Assisted Tomography) trial
    Udo Hoffmann
    Cardiac MR PET CT Program, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Am Coll Cardiol 53:1642-50. 2009
    ..This study was designed to determine the usefulness of coronary computed tomography angiography (CTA) in patients with acute chest pain...
  13. ncbi Use of multidetector computed tomography for the assessment of acute chest pain: a consensus statement of the North American Society of Cardiac Imaging and the European Society of Cardiac Radiology
    Arthur E Stillman
    Department of Radiology, Emory University, Atlanta, GA, USA
    Eur Radiol 17:2196-207. 2007
  14. ncbi Associations of long-term and early adult atherosclerosis risk factors with aortic and mitral valve calcium
    George Thanassoulis
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    J Am Coll Cardiol 55:2491-8. 2010
    ..To determine the association of long-term exposure to atherosclerosis risk factors with valvular calcification...
  15. ncbi Incremental diagnostic value of regional left ventricular function over coronary assessment by cardiac computed tomography for the detection of acute coronary syndrome in patients with acute chest pain: from the ROMICAT trial
    Sujith K Seneviratne
    Cardiac MR PET CT Program, Department of Radiology and Division of Cardiology, Massachusetts General Hospital and Harvard Medical School, 165 Charles River Plaza, Boston, MA 02114, USA
    Circ Cardiovasc Imaging 3:375-83. 2010
    ..The incremental value of regional left ventricular function (LVF) over coronary assessment to detect acute coronary syndrome (ACS) is uncertain...
  16. ncbi Prognostic value of CT angiography for major adverse cardiac events in patients with acute chest pain from the emergency department: 2-year outcomes of the ROMICAT trial
    Christopher L Schlett
    Cardiac MR PET CT Program, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    JACC Cardiovasc Imaging 4:481-91. 2011
    ..The aim of this study was to determine the 2-year prognostic value of cardiac computed tomography (CT) for predicting major adverse cardiac events (MACE) in patients presenting to the emergency department (ED) with acute chest pain...
  17. ncbi Usefulness of age and gender in the early triage of patients with acute chest pain having cardiac computed tomographic angiography
    Fabian Bamberg
    Massachusetts General Hospital and Harvard Medical School, Boston, USA
    Am J Cardiol 104:1165-70. 2009
    ..Thus, age and gender might serve as simple criteria to appropriately select patients who would derive the greatest diagnostic benefit from coronary CTA in the setting of acute chest pain...
  18. ncbi Intramuscular fat and associations with metabolic risk factors in the Framingham Heart Study
    Kate E Therkelsen
    Boston University School of Medicine, Boston, MA, USA
    Arterioscler Thromb Vasc Biol 33:863-70. 2013
    ..CONCLUSIONS: MA was associated with metabolic risk factors, but most of these associations were lost after adjustment for BMI or VAT. However, a unique association remained for metabolic syndrome in women and lipids in men...
  19. ncbi Aminotransferase levels are associated with cardiometabolic risk above and beyond visceral fat and insulin resistance: the Framingham Heart Study
    Stacy A Porter
    Center for Population Studies, National Heart, Lung, and Blood Institute, Framingham, MA, USA
    Arterioscler Thromb Vasc Biol 33:139-46. 2013
    ..We sought to characterize associations between aminotransferase levels and cardiometabolic risk after accounting for visceral adipose tissue and insulin resistance...
  20. ncbi MDCT in early triage of patients with acute chest pain
    Udo Hoffmann
    Department of Radiology, Massachusetts General Hospital Cardiac MR CT PET Program and Harvard Medical School, 100 CPZ 400, Boston, MA 02114, USA
    AJR Am J Roentgenol 187:1240-7. 2006
    ..We sought to determine whether contrast-enhanced MDCT-based detection of stenosis is feasible and improves early and accurate triage of patients with acute chest pain...
  21. ncbi Cardiac CT in emergency department patients with acute chest pain
    Udo Hoffmann
    Department of Radiology, Massachusetts General Hospital, 165 Charles River Plaza, Suite 400, Boston, MA 02114, USA
    Radiographics 26:963-78; discussion 979-80. 2006
    ....
  22. ncbi Utility of nonspecific resting electrocardiographic features for detection of coronary artery stenosis by computed tomography in acute chest pain patients: from the ROMICAT trial
    Quynh A Truong
    Cardiac MR PET CT Program, Massachusetts General Hospital and Harvard Medical School, 165 Cambridge Street, Suite 400, Boston, MA 02114, USA
    Int J Cardiovasc Imaging 28:365-74. 2012
    ....
  23. ncbi Comparison of exercise treadmill testing with cardiac computed tomography angiography among patients presenting to the emergency room with chest pain: the Rule Out Myocardial Infarction Using Computer-Assisted Tomography (ROMICAT) study
    Ron Blankstein
    Department of Medicine Cardiovascular Division and Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Circ Cardiovasc Imaging 5:233-42. 2012
    ....
  24. ncbi Incremental value of adenosine-induced stress myocardial perfusion imaging with dual-source CT at cardiac CT angiography
    Jose A Rocha-Filho
    Department of Radiology, Massachusetts General Hospital, Boston, Mass, USA
    Radiology 254:410-9. 2010
    ....
  25. ncbi Association of pericardial fat, intrathoracic fat, and visceral abdominal fat with cardiovascular disease burden: the Framingham Heart Study
    Amir A Mahabadi
    Cardiac MR PET CT Program, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, 165 Charles River Plaza, Boston, MA 02114, USA
    Eur Heart J 30:850-6. 2009
    ..The aim of this study was to assess whether pericardial fat, intrathoracic fat, and visceral abdominal adipose tissue (VAT) are associated with the prevalence of cardiovascular disease (CVD)...
  26. ncbi Analytic approaches to establish the diagnostic accuracy of coronary computed tomography angiography as a tool for clinical decision making
    Michael D Shapiro
    Cardiac MR PET CT Program, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Cardiol 99:1122-7. 2007
    ..In conclusion, the clinical utility of coronary CTA may be limited by a low PPV in patients with a high prevalence of coronary artery disease...
  27. ncbi Comprehensive assessment of myocardial perfusion defects, regional wall motion, and left ventricular function by using 64-section multidetector CT
    Ricardo C Cury
    Department of Radiology, Cardiac MR PET CT Program, Massachusetts General Hospital and Harvard Medical School, 165 Cambridge St, Suite 400, Boston, MA 02114, USA
    Radiology 248:466-75. 2008
    ..To evaluate the accuracy of 64-section multidetector computed tomography (CT) for the assessment of perfusion defects (PDs), regional wall motion (RWM), and global left ventricular (LV) function...
  28. ncbi Coronary multidetector computed tomography in the assessment of patients with acute chest pain
    Udo Hoffmann
    Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 165 Charles River Plaza, Ste 400, Boston, MA 02114, USA
    Circulation 114:2251-60. 2006
    ....
  29. ncbi Assessment of coronary plaque progression in coronary computed tomography angiography using a semiquantitative score
    Sam J Lehman
    Cardiac MR PET CT Program, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    JACC Cardiovasc Imaging 2:1262-70. 2009
    ..We sought to describe the progression of coronary atherosclerotic plaque over time by computed tomography (CT) angiography stratified by plaque composition and its association with cardiovascular risk profiles...
  30. ncbi Fatty kidney, hypertension, and chronic kidney disease: the Framingham Heart Study
    Meredith C Foster
    Framingham Heart Study, Framingham, MA, USA
    Hypertension 58:784-90. 2011
    ..In conclusion, fatty kidney is a common condition that is associated with an increased risk of hypertension and chronic kidney disease. Renal sinus fat may play a role in blood pressure regulation and chronic kidney disease...
  31. ncbi Association between cardiovascular risk profiles and the presence and extent of different types of coronary atherosclerotic plaque as detected by multidetector computed tomography
    Fabian Bamberg
    Cardiac MR PET CT Program, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Arterioscler Thromb Vasc Biol 28:568-74. 2008
    ..To assess the association between cardiovascular risk factors and extent of noncalcified- (NCAP), mixed- (MCAP), and calcified coronary atherosclerotic plaque (CAP)...
  32. ncbi Reperfused myocardial infarction: contrast-enhanced 64-Section CT in comparison to MR imaging
    Koen Nieman
    Cardiac MRI PET CT Program, Department of Radiology and the Cardiology Division, Massachusetts General Hospital and Harvard Medical School, 165 Cambridge St, Boston, MA 02114, USA
    Radiology 247:49-56. 2008
    ..To prospectively compare 64-section multidetector computed tomography (CT) and cardiac magnetic resonance (MR) imaging for the early assessment of myocardial enhancement and infarct size after acute reperfused myocardial infarction (MI)...
  33. ncbi The effect of heart rhythm on patient radiation dose with dual-source cardiac computed tomography
    Tust Techasith
    Cardiac MR PET CT Program, Department of Radiology and Division of Cardiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    J Cardiovasc Comput Tomogr 5:255-63. 2011
    ..To lower the radiation exposure associated with cardiac CT, it is essential to identify all factors that influence radiation dose...
  34. ncbi Feasibility of FDG imaging of the coronary arteries: comparison between acute coronary syndrome and stable angina
    Ian S Rogers
    Cardiac MR PET CT Program, Division of Cardiology and Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    JACC Cardiovasc Imaging 3:388-97. 2010
    ....
  35. ncbi Prevalence, distribution, and risk factor correlates of high pericardial and intrathoracic fat depots in the Framingham heart study
    George Thanassoulis
    National Institutes of Health National Heart, Lung, and Blood Institute, Framingham Heart Study, Framingham, MA, Boston, USA
    Circ Cardiovasc Imaging 3:559-66. 2010
    ..We sought to determine the prevalence, distribution, and risk factor correlates of high pericardial and intrathoracic fat deposits...
  36. ncbi Comparison of the Diamond-Forrester method and Duke Clinical Score to predict obstructive coronary artery disease by computed tomographic angiography
    Meagan M Wasfy
    Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Am J Cardiol 109:998-1004. 2012
    ..These results identify the need for improved pretest risk scores for noninvasive tests such as CCTA and suggest that the method of risk assessment could have important implications for patient selection and quality assurance programs...
  37. ncbi Comparison of measurement of cross-sectional coronary atherosclerotic plaque and vessel areas by 16-slice multidetector computed tomography versus intravascular ultrasound
    Fabian Moselewski
    Division of Cardiology, Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Am J Cardiol 94:1294-7. 2004
    ..The mean luminal area and mean plaque area were slightly but significantly overestimated with MDCT. MDCT permits the noninvasive measurement of coronary cross-sectional luminal and plaque areas with moderate accuracy...
  38. ncbi Association of visceral and subcutaneous adiposity with kidney function
    Jill A Young
    Tufts New England Medical Center, Boston, Massachusetts, USA
    Clin J Am Soc Nephrol 3:1786-91. 2008
    ..Visceral (VAT) and subcutaneous adipose tissue (SAT) may confer differential metabolic risk profiles. The relations of VAT and SAT were analyzed with CKD as estimated by creatinine- and cystatin-based estimating equations...
  39. ncbi Epidemiology and association of vascular and valvular calcium quantified by multidetector computed tomography in elderly asymptomatic subjects
    Ricardo C Cury
    Department of Radiology, Massachusetts General Hospital, Boston, 02114, USA
    Am J Cardiol 94:348-51. 2004
    ..Further evidence is provided for the notion that calcifications in those regions are associated and that MDCT can be used as a tool for the global assessment of vascular and valvular calcium...
  40. ncbi Comparison of postprocessing techniques for the detection of perfusion defects by cardiac computed tomography in patients presenting with acute ST-segment elevation myocardial infarction
    Ian S Rogers
    Department of Radiology and Division of Cardiology, Massachusetts General Hospital, Boston, MA 02114 2750, USA
    J Cardiovasc Comput Tomogr 4:258-66. 2010
    ..Despite rapid advances in cardiac computed tomography (CT), a strategy for optimal visualization of perfusion abnormalities on CT has yet to be validated...
  41. ncbi Pericardial fat volume correlates with inflammatory markers: the Framingham Heart Study
    Thomas M Tadros
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Boston, Massachusetts, USA
    Obesity (Silver Spring) 18:1039-45. 2010
    ..Multiple markers of inflammation and oxidative stress correlated with pericardial and intrathoracic fat volumes, extending the known association between regional adiposity and inflammation and oxidative stress...
  42. ncbi Diagnostic accuracy of image postprocessing methods for the detection of coronary artery stenoses by using multidetector CT
    Maros Ferencik
    Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Radiology 243:696-702. 2007
    ....
  43. ncbi Evidence for lower variability of coronary artery calcium mineral mass measurements by multi-detector computed tomography in a community-based cohort--consequences for progression studies
    Udo Hoffmann
    Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 100 Charles River Plaza Suite 400, Boston, MA 02114, USA
    Eur J Radiol 57:396-402. 2006
    ....
  44. ncbi A comprehensive electrocardiogram-gated 64-slice multidetector computed tomography imaging protocol to visualize the coronary arteries, thoracic aorta, and pulmonary vasculature in a single breath hold
    Michael D Shapiro
    Cardiac MR PET CT Program, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Comput Assist Tomogr 33:225-32. 2009
    ....
  45. ncbi Axial area and anteroposterior diameter as estimates of left atrial size using computed tomography of the chest: comparison with 3-dimensional volume
    Amir A Mahabadi
    Cardiac MR PET CT Program, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, 165 Cambridge Street, Suite 400, Boston, MA 02114, USA
    J Cardiovasc Comput Tomogr 4:49-54. 2010
    ..Left atrial (LA) size has incremental value in risk stratification...
  46. ncbi Adiposity, cardiometabolic risk, and vitamin D status: the Framingham Heart Study
    Susan Cheng
    Framingham Heart Study, Framingham, Massachusetts, USA
    Diabetes 59:242-8. 2010
    ..Few studies relating vitamin D deficiency to obesity have included direct measures of adiposity. Furthermore, the degree to which vitamin D is associated with metabolic traits after adjusting for adiposity measures is unclear...
  47. ncbi Indexes of kidney function and coronary artery and abdominal aortic calcium (from the Framingham Offspring Study)
    Nisha I Parikh
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Am J Cardiol 102:440-3. 2008
    ..Neither cysC nor MA was significantly associated with AAC in age- and gender- or multivariable-adjusted models. In conclusion, CKD, cysC, and MA are not associated with CAC or AAC when accounting for cardiovascular disease risk factors...
  48. ncbi Incremental value of myocardial perfusion over regional left ventricular function and coronary stenosis by cardiac CT for the detection of acute coronary syndromes in high-risk patients: a subgroup analysis of the ROMICAT trial
    Hiram G Bezerra
    Cardiac MR PET CT Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Cardiovasc Comput Tomogr 5:382-91. 2011
    ..To determine the incremental benefit of assessing myocardial perfusion defects (MPD) for acute coronary syndromes (ACS) over coronary and functional assessment by rest cardiac computed tomography (CT) in patients with acute chest pain...
  49. ncbi Multidetector computed tomography for the detection of left atrial appendage thrombus: a comparative study with transesophageal echocardiography
    Michael D Shapiro
    Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    J Comput Assist Tomogr 31:905-9. 2007
    ..To determine the diagnostic performance of multidetector computed tomography (MDCT) for the detection of left atrial appendage (LAA) thrombus as compared with transesophageal echocardiography...
  50. ncbi Reference values for normal pulmonary artery dimensions by noncontrast cardiac computed tomography: the Framingham Heart Study
    Quynh A Truong
    Cardiac MR PET CT Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Circ Cardiovasc Imaging 5:147-54. 2012
    ..We determined the age- and sex-specific distribution and normal reference values for mPA and ratio PA by CT in an asymptomatic community-based population...
  51. ncbi Comparison of multidetector computed tomography and two-dimensional transthoracic echocardiography for left ventricular assessment in patients with heart failure
    Javed Butler
    Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Cardiol 99:247-9. 2007
    ..72 for LV end-diastolic volume) to excellent (r = 0.84 for septal wall thickness). In conclusion, MDCT provides comparable results to TTE for LV structure and functional assessment among patients with HF...
  52. ncbi Association of aortic valve calcification to the presence, extent, and composition of coronary artery plaque burden: from the Rule Out Myocardial Infarction using Computer Assisted Tomography (ROMICAT) trial
    Amir A Mahabadi
    Cardiac MR PET CT Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Am Heart J 158:562-8. 2009
    ..We sought to determine whether AVC is associated with the presence and extent of overall plaque burden, as well as to plaque composition (calcified, mixed, and noncalcified)...
  53. ncbi Accuracy of 16-slice multi-detector CT to quantify the degree of coronary artery stenosis: assessment of cross-sectional and longitudinal vessel reconstructions
    Ricardo C Cury
    Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA
    Eur J Radiol 57:345-50. 2006
    ..The purpose of this study was to determine the accuracy of MDCT to quantify the degree of coronary stenosis as compared to quantitative coronary angiography (QCA) using two different reconstruction methods...
  54. ncbi Quantitative assessment of left atrial volume by electrocardiographic-gated contrast-enhanced multidetector computed tomography
    Amir A Mahabadi
    Cardiac MR PET CT Program, Department of Radiology and Division of Cardiology, Massachusetts General Hospital, 165 Cambridge Street, Suite 400, Boston, MA 02114, USA
    J Cardiovasc Comput Tomogr 3:80-7. 2009
    ..Left atrial (LA) volume is a predictor of cardiovascular events. Information on LA volume is available on contrast-enhanced electrocardiogram (EGC)-gated multidetector computed tomography (MDCT) scans...
  55. ncbi Efficacy of pre-scan beta-blockade and impact of heart rate on image quality in patients undergoing coronary multidetector computed tomography angiography
    Michael D Shapiro
    Cardiac MR PET CT Program, Massachusetts General Hospital and Harvard Medical School, Boston MA 02114, USA
    Eur J Radiol 66:37-41. 2008
    ..We therefore assessed the efficacy of beta-blockade with regards to heart rate (HR) control and image quality in an unselected patient cohort...
  56. ncbi Differentiation of recent and chronic myocardial infarction by cardiac computed tomography
    Koen Nieman
    Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Am J Cardiol 98:303-8. 2006
    ..05), whereas recent MI was not (p > 0.05). In conclusion, recent and long-standing MIs may be differentiated by computed tomography based on myocardial CT attenuation values and ventricular dimensions...
  57. ncbi Direct comparison of rest and adenosine stress myocardial perfusion CT with rest and stress SPECT
    David R Okada
    Cardiac MR PET CT Program, Department of Radiology and Division of Cardiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    J Nucl Cardiol 17:27-37. 2010
    ..The aim of this study was to determine the level of agreement between CTP and SPECT-MPI at rest and under stress on a per-segment, per-vessel, and per-patient basis...
  58. ncbi Comparison of sixty-four-slice multidetector computed tomographic coronary angiography to coronary angiography with intravascular ultrasound for the detection of transplant vasculopathy
    Shawn A Gregory
    Cardiology Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Am J Cardiol 98:877-84. 2006
    ..Further, MDCT measurements of lumen diameters correlated well with quantitative coronary angiography...
  59. ncbi Improved vessel morphology measurements in contrast-enhanced multi-detector computed tomography coronary angiography with non-linear post-processing
    Maros Ferencik
    Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 165 Cambridge Street, Suite 400, Boston, MA 02114, USA
    Eur J Radiol 57:380-3. 2006
    ..Post-processing to reduce blurring and noise reduced variability of wall area measurements and reduced measurement bias for both wall area and vessel cross-sectional area...
  60. ncbi A novel model to test accuracy and reproducibility of MDCT scan protocols for coronary calcium in vivo
    Michael Rosol
    Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Int J Cardiovasc Imaging 22:111-8. 2006
    ..CONCLUSIONS: At high heart rates prospective ECG triggered image reconstruction is more accurate and reproducible for CAC scoring than retrospective ECG gated reconstruction and non-gated reconstruction...
  61. ncbi Use of 100 kV versus 120 kV in cardiac dual source computed tomography: effect on radiation dose and image quality
    Ron Blankstein
    Cardiac MR PET CT Program, Department of Radiology, Division of Cardiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Int J Cardiovasc Imaging 27:579-86. 2011
    ..02). In selected non-obese patients, use of low kV results in a substantial reduction of radiation dose and may result in improved image quality. These results suggest that low kV should be used more frequently in non-obese patients...
  62. ncbi Calcium concentration of individual coronary calcified plaques as measured by multidetector row computed tomography
    Fabian Moselewski
    Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Mass 02114, USA
    Circulation 111:3236-41. 2005
    ....
  63. ncbi Abdominal subcutaneous and visceral adipose tissue and insulin resistance in the Framingham heart study
    Sarah R Preis
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Obesity (Silver Spring) 18:2191-8. 2010
    ..003), where VAT had a stronger association in obese individuals. In conclusion, SAT and VAT are both correlates of insulin resistance; however, VAT is a stronger correlate of insulin resistance than SAT...
  64. ncbi A computed tomography-based coronary lesion score to predict acute coronary syndrome among patients with acute chest pain and significant coronary stenosis on coronary computed tomographic angiogram
    Maros Ferencik
    Cardiology Division, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Am J Cardiol 110:183-9. 2012
    ....
  65. ncbi Differential associations between blood biomarkers of inflammation, oxidation, and lipid metabolism with varying forms of coronary atherosclerotic plaque as quantified by coronary CT angiography
    Fabian Bamberg
    Massachusetts General Hospital, Cardiac MR PET CT Program, Harvard Medical School, Boston, MA, USA
    Int J Cardiovasc Imaging 28:183-92. 2012
    ..Biomarkers reflecting inflammation, vascular remodeling, oxidation, and lipoprotein metabolism maybe associated with different patterns of coronary atherosclerosis as quantified by coronary CT angiography...
  66. ncbi Volumetric measurement of pericardial adipose tissue from contrast-enhanced coronary computed tomography angiography: a reproducibility study
    John H Nichols
    Department of Radiology, Massachusetts General Hospital, 165 Cambridge Street, Suite 400, Boston, MA 02114, USA
    J Cardiovasc Comput Tomogr 2:288-95. 2008
    ..The reproducibility of electrocardiogram-gated high-resolution cardiac MDCT-based volumetric quantification of pericardial and intrathoracic adipose tissue has not been reported...
  67. ncbi Cross-sectional associations between abdominal and thoracic adipose tissue compartments and adiponectin and resistin in the Framingham Heart Study
    Shilpa H Jain
    Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Diabetes Care 32:903-8. 2009
    ....
  68. ncbi Eligibility of individuals with subclinical coronary artery calcium and intermediate coronary heart disease risk for reclassification (from the Framingham Heart Study)
    Sarah Rosner Preis
    Center for Population Studies, National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Am J Cardiol 103:1710-5. 2009
    ..Approximately 25% of intermediate-risk individuals have high CAC scores and may be eligible for reclassification into a higher-risk category...
  69. ncbi Left atrial volume and index by multi-detector computed tomography: comprehensive analysis from predictors of enlargement to predictive value for acute coronary syndrome (ROMICAT study)
    Quynh A Truong
    Cardiac MR PET CT Program, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Int J Cardiol 146:171-6. 2011
    ..We aimed to identify the predictors of left atrial (LA) enlargement by multi-detector computed tomography (CT) and determine its association and predictive value for acute coronary syndrome (ACS)...
  70. ncbi Predictors of image quality of coronary computed tomography in the acute care setting of patients with chest pain
    Fabian Bamberg
    Cardiac MR PET CT Program, Department of Radiology and Division of Cardiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States
    Eur J Radiol 74:182-8. 2010
    ..We aimed to determine predictors of image quality in consecutive patients who underwent coronary computed tomography (CT) for the evaluation of acute chest pain...
  71. ncbi Threshold-dependent variability of coronary artery calcification measurements -- implications for contrast-enhanced multi-detector row-computed tomography
    Fabian Moselewski
    Division of Cardiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Eur J Radiol 57:390-5. 2006
    ..Due to the similarity of mean CT attenuation of CAC and the contrast-enhanced coronary lumen accurate quantification of CAC may be difficult in standard coronary contrast-enhanced spiral MDCT...
  72. ncbi Peri-aortic fat, cardiovascular disease risk factors, and aortic calcification: the Framingham Heart Study
    Sam J Lehman
    Massachusetts General Hospital, Department of Cardiac MR PET CT and Harvard University, Boston, MA, United States
    Atherosclerosis 210:656-61. 2010
    ..We sought to examine associations between adipose tissue depots immediately surrounding the thoracic aorta, metabolic risk factors, and vascular calcification...
  73. ncbi Analysis of cardiac dimensions, mass and function in heart transplant recipients using 64-slice multi-detector computed tomography
    Maros Ferencik
    Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Heart Lung Transplant 26:478-84. 2007
    ..The aim of this study was to compare 64-slice MDCT analysis of cardiac structure and function to 2-dimensional echocardiography in heart transplant recipients...
  74. ncbi Diagnostic and prognostic value of absence of coronary artery calcification
    Ammar Sarwar
    Cardiac PET CT MRI Program, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    JACC Cardiovasc Imaging 2:675-88. 2009
    ..In this study, we systematically assessed the diagnostic and prognostic value of absence of coronary artery calcification (CAC) in asymptomatic and symptomatic individuals...
  75. ncbi Utility of cardiovascular magnetic resonance to predict left ventricular recovery after primary percutaneous coronary intervention for patients presenting with acute ST-segment elevation myocardial infarction
    Michael D Shapiro
    Cardiac MR PET CT Program, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Am J Cardiol 100:211-6. 2007
    ..90, 95% CI 0.58 to 1.40, p = 0.64). In conclusion, when using the delayed enhancement technique for assessment of DHE and MVO, degree of infarct transmurality appears to be a more powerful predictor of LV recovery by CMR...
  76. ncbi Predictive value of 16-slice multidetector spiral computed tomography to detect significant obstructive coronary artery disease in patients at high risk for coronary artery disease: patient-versus segment-based analysis
    Udo Hoffmann
    Department of Radiology, Massachusetts General Hospital, 100 Charles River Plaza, Ste 400, Boston, MA 02114, USA
    Circulation 110:2638-43. 2004
    ....
  77. ncbi The disposition decision on emergency department patients with chest pain is affected by the results of multi-detector computed axial tomography scan of the coronary arteries
    John T Nagurney
    Department of Emegency Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Emerg Med 39:57-64. 2010
    ..We measured if and how often these changes in decision-making would occur...
  78. ncbi Detection of calcified and noncalcified coronary atherosclerotic plaque by contrast-enhanced, submillimeter multidetector spiral computed tomography: a segment-based comparison with intravascular ultrasound
    Stephan Achenbach
    Department of Radiology, Massachusetts General Hospital, Boston, USA
    Circulation 109:14-7. 2004
    ..We investigated the ability of multidetector spiral computed tomography (MDCT) to detect atherosclerotic plaque in nonstenotic coronary arteries...
  79. ncbi Usefulness of electrocardiographic parameters as compared with computed tomography measures of left atrial volume enlargement: from the ROMICAT trial
    Quynh A Truong
    Cardiac MR PET CT Program, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    J Electrocardiol 44:257-64. 2011
    ..We aimed to determine the diagnostic performance of 6 ECG criteria for LAE as compared with CT left atrial volume (LAV) and index to body surface area (LAVI) as the reference standard...
  80. ncbi Relation of the metabolic syndrome to quantity of coronary atherosclerotic plaque
    Javed Butler
    Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Cardiol 101:1127-30. 2008
    ..These data may explain the higher cardiovascular risk in these patients and may lay the foundation for studies to determine whether such information may improve risk stratification...
  81. ncbi Association of colony-forming units with coronary artery and abdominal aortic calcification
    Susan Cheng
    Cardiology Division, GRB 800, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Circulation 122:1176-82. 2010
    ..Experimental data suggest that depletion of these angiogenic cell populations may promote atherogenesis, but limited data are available on their relation to subclinical atherosclerotic cardiovascular disease in humans...
  82. ncbi Use of multidetector computed tomography for the assessment of acute chest pain: a consensus statement of the North American Society of Cardiac Imaging and the European Society of Cardiac Radiology
    Arthur E Stillman
    Department of Radiology, Emory University, Atlanta, GA, USA
    Int J Cardiovasc Imaging 23:415-27. 2007
  83. ncbi Usefulness of coronary computed tomographic angiography to assess suitability for revascularization in patients with significant coronary artery disease and angina pectoris
    Tej N Sheth
    Cardiac MR PETCT Program, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Am J Cardiol 98:1198-201. 2006
    ....
  84. ncbi Multimodality imaging of pericardial diseases
    Kibar Yared
    Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    JACC Cardiovasc Imaging 3:650-60. 2010
    ..This report reviews the imaging modalities most useful in the assessment of patients with pericardial disease, with an emphasis on the complementary value of multimodality cardiac imaging...
  85. ncbi Relationship of the esophagus and aorta to the left atrium and pulmonary veins: implications for catheter ablation of atrial fibrillation
    Ricardo C Cury
    Cardiac CT Unit, Massachusetts General Hospital-Harvard Medical School, Boston, 02114, USA
    Heart Rhythm 2:1317-23. 2005
    ..CONCLUSION: In addition to its ability to assess PV anatomy, preprocedural MDCT imaging can investigate the variable relationship of adjacent structures, such as the esophagus and aorta to the LA and PVs...
  86. ncbi Clinical outcomes and cost-effectiveness of coronary computed tomography angiography in the evaluation of patients with chest pain
    Joseph A Ladapo
    Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    J Am Coll Cardiol 54:2409-22. 2009
    ....
  87. ncbi Tomographic coronary angiography by EBCT and MDCT
    Stephan Achenbach
    Department of Radiology, Massachusetts General Hospital, Boston 02114, USA
    Prog Cardiovasc Dis 46:185-95. 2003
    ..Other applications include the analysis of bypass patency and evaluation of coronary anomalies...
  88. ncbi Coronary stent assessability by 64 slice multi-detector computed tomography
    Tej Sheth
    Cardiac MR PET CT Program, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Catheter Cardiovasc Interv 69:933-8. 2007
    ..We evaluated the assessability of contemporary stent platforms by 64-slice multi-detector computed tomography (MDCT)...
  89. ncbi Quantitative parameters of image quality in 64-slice computed tomography angiography of the coronary arteries
    Maros Ferencik
    Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 165 Cambridge Street, Suite 400, Boston, MA, USA
    Eur J Radiol 57:373-9. 2006
    ..Low heart rate is an important prerequisite for excellent image quality...
  90. ncbi Potential uses of computed tomography for management of heart failure patients with dyssynchrony
    Quynh A Truong
    Cardiac MR PET CT Program, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Crit Pathw Cardiol 7:185-90. 2008
    ..We present here the potential concept of using cardiac computed tomography as a single modality to acquire functional and anatomic information, and also to show the possibility of integrating this with real time fluoroscopy...
  91. ncbi Assessment of coronary remodeling in stenotic and nonstenotic coronary atherosclerotic lesions by multidetector spiral computed tomography
    Stephan Achenbach
    Department of Radiology, Massachusetts General Hospital, Boston, MA, USA
    J Am Coll Cardiol 43:842-7. 2004
    ..This study was designed to investigate whether contrast-enhanced multidetector spiral CT (MDCT) permits assessment of remodeling in coronary atherosclerotic lesions...
  92. ncbi Relation of natriuretic peptides and midregional proadrenomedullin to cardiac chamber volumes by computed tomography in patients without heart failure: from the ROMICAT Trial
    Quynh A Truong
    Cardiac MR PET CT Program, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Clin Chem 56:651-60. 2010
    ....
  93. ncbi Coronary artery plaques and myocardial ischaemia
    Paul Stolzmann
    Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, Zurich, Switzerland
    Eur Radiol 21:1628-34. 2011
    ..To prospectively examine coronary artery plaques as predictors of myocardial ischaemia using cardiac magnetic resonance (CMR)...
  94. ncbi Acute myocardial infarction: contrast-enhanced multi-detector row CT in a porcine model
    Udo Hoffmann
    Department of Radiology, Division of Cardiology, Massachusetts General Hospital and Harvard Medical School, 100 Charles River Plaza, Suite 400, Boston, MA 02114, USA
    Radiology 231:697-701. 2004
    ....
  95. ncbi Evaluation of retrospective multisector and half scan ECG-gated multidetector cardiac CT protocols with moving phantoms
    Stephan Wicky
    Massachusetts General Hospital, Department of Radiology, 55 Fruit Street, Boston MA 02114, USA
    J Comput Assist Tomogr 26:768-76. 2002
    ..We evaluated independently retrospective half scan and multisector mode manufacturer's protocols and compared them with modified acquisition protocols to determine optimal imaging parameters for cardiac scanning...
  96. ncbi Perceived usefulness of cardiac computed tomography as assessed by referring physicians and its effect on patient management
    Ron Blankstein
    Cardiac MR PET CT Program, Department of Radiology and Division of Cardiology, Massachusetts General Hospital, Boston, MA, USA
    Am J Cardiol 105:1246-53. 2010
    ..In conclusion, of 53 different referring clinicians from different medical specialties, CTA was considered to almost always be useful; however, the effect on subsequent medical management was more variable...
  97. ncbi Quantification of left ventricular noncompaction and trabecular delayed hyperenhancement with cardiac MRI: correlation with clinical severity
    Jonathan D Dodd
    Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    AJR Am J Roentgenol 189:974-80. 2007
    ....
  98. ncbi Cardiac septal aneurysm mimicking pseudomass: appearance on ECG-gated cardiac MRI and MDCT
    Jonathan D Dodd
    Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 55 Fruit St, Boston, MA 02114, USA
    AJR Am J Roentgenol 188:W550-3. 2007
    ..It is important that radiologists recognize such an entity on chest CT and MRI because of the association with intracardiac shunting and stroke and to avoid misdiagnosis of an aneurysm as a cardiac tumor...
  99. ncbi Liver fat is reproducibly measured using computed tomography in the Framingham Heart Study
    Elizabeth K Speliotes
    Departments of Gastroenterology, Massachusettes General Hospital, Massachusetts, USA
    J Gastroenterol Hepatol 23:894-9. 2008
    ..We sought to determine the feasibility of and optimal protocol for quantifying fat content in the liver in the Framingham Heart Study using multidetector computed tomography (MDCT) scanning...
  100. ncbi Feasibility and optimization of aortic valve planimetry with MDCT
    Suhny Abbara
    Department of Radiology, Massachusetts General Hospital, 165 Cambridge St, Ste 400, Boston, MA 02114, USA
    AJR Am J Roentgenol 188:356-60. 2007
    ..The aortic valve can be assessed using MDCT; however, measurements of the aortic opening area vary with the cardiac cycle. In this study, we sought to assess the optimal timing for measuring the area of the aortic opening with MDCT...
  101. ncbi Cardiac CT assessment of left atrial accessory appendages and diverticula
    Suhny Abbara
    Department of Radiology, Section of Cardiovascular Imaging, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St GRB 290, Boston, MA 02114 2696, USA
    AJR Am J Roentgenol 193:807-12. 2009
    ....

Research Grants4

  1. Cardiac MDCT for Early Triage of Patients with ACS
    Udo Hoffmann; Fiscal Year: 2006
    ....
  2. PROMISE Trial: Dx Core
    Udo Hoffmann; Fiscal Year: 2009
    ..L Lee, PI), an Economics and Quality of Life (EQOL; Daniel B Mark, PI), and a Diagnostic Test Core (Dx Core; Udo Hoffmann, PI)...
  3. PROMISE Trial: Dx Core
    Udo Hoffmann; Fiscal Year: 2010
    ..L Lee, PI), an Economics and Quality of Life (EQOL;Daniel B Mark, PI), and a Diagnostic Test Core (Dx Core;Udo Hoffmann, PI)...