Research Topics
Genomes and Genes
| I cheng HoSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
Research Grants
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Detail Information
Publications
m(en)TOR(ing) differentiating T helper cellsI cheng Ho
Department of Medicine, Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Immunity 30:759-61. 2009..In this issue of Immunity, Delgoffe et al. (2009) use genetic approaches and demonstrate that mTOR kinase plays a critical role in this decision-making process...
GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiationI cheng Ho
Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Nat Rev Immunol 9:125-35. 2009..In addition, we discuss the interactions between GATA3 and other transcription factors and signalling pathways, and highlight the functional significance of the GATA3 protein structure...
GATA-3 - not just for Th2 cells anymoreI cheng Ho
Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Cell Mol Immunol 4:15-29. 2007..Not only does GATA-3 participate in nearly every stage of T cell development from common lymphoid progenitor to Th2, conditional knockout studies have indicated that the influence of GATA-3 also extends beyond the immune system...- An IL-4-independent and CD25-mediated function of c-maf in promoting the production of Th2 cytokinesEun Sook Hwang
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 99:13026-30. 2002..Taken together, our results uncover an IL-4-independent and CD25-mediated function of c-maf in promoting the production of Th2 cytokines... - GATA-3 regulates the development and function of invariant NKT cellsPeter J Kim
Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
J Immunol 177:6650-9. 2006..In addition, GATA-3 is also required for survival, activation, and effector functions of this unique population of T cells. Our data also reveal a previously unidentified peripheral maturation step that is GATA-3 dependent... - A repressor of GATA-mediated negative feedback mechanism of T cell activationShi Chuen Miaw
Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Immunol 172:170-7. 2004..Restoration of ROG expression in vivo partly corrects the hyperproliferation of NF-ATc2-deficient Th cells by attenuating TCR signals. Our data, therefore, depict a ROG-mediated negative feedback mechanism of T cell activation... - Transcriptional regulation of GATA-3 by an intronic regulatory region and fetal liver zinc finger protein 1Eun Sook Hwang
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
J Immunol 169:248-53. 2002..Our data suggest that the expression of GATA-3 might be partly regulated by the intronic regulatory region and Fliz1 in a developmental stage-specific fashion... - Ets-1 is a negative regulator of Th17 differentiationJacques Moisan
Rheumatology, Immunology and Allergy, Brigham and Women s Hospital Harvard Medical School, Boston, MA 02115, USA
J Exp Med 204:2825-35. 2007..Based on these observations, we report that Ets-1 is a negative regulator of Th17 differentiation... - ROG negatively regulates T-cell activation but is dispensable for Th-cell differentiationBok Yun Kang
Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Brigham and Women s HospitalSmith Building, Room 524, One Jimmy Fund Way, Boston, MA 02115, USA
Mol Cell Biol 25:554-62. 2005..Its mechanism of action and its expression pattern are distinct from those of other transcription factors negatively regulating the activation of T cells... - GATA-3 deficiency abrogates the development and maintenance of T helper type 2 cellsSung Yun Pai
Department of Pediatric Hematology Oncology, Dana Farber Cancer Institute and Children s Hospital, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 101:1993-8. 2004..Using a conditional knockout approach, we found that GATA-3 is required for optimal Th2 cytokine production in vitro and in vivo. Our data also show that GATA-3 expression must be sustained to maintain the Th2 phenotype... - Ets-1, a functional cofactor of T-bet, is essential for Th1 inflammatory responsesRoland Grenningloh
Department of Medicine, Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Boston, MA 02115, USA
J Exp Med 201:615-26. 2005..In addition, Ets-1-deficient Th1 cells also produce a very high level of interleukin 10. Thus, Ets-1 plays a crucial and unique role in the reciprocal regulation of inflammatory and antiinflammatory Th responses... - Critical roles for transcription factor GATA-3 in thymocyte developmentSung Yun Pai
Department of Pediatric Hematology Oncology, Dana Farber Cancer Institute and Children s Hospital, Boston, MA 02115, USA
Immunity 19:863-75. 2003..Thus, our data demonstrate that the coordinated and regulated expression of GATA-3 at each stage of thymic development is critical for the generation of mature T cells... - Cysteinyl leukotrienes regulate Th2 cell-dependent pulmonary inflammationDaniel C Kim
Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
J Immunol 176:4440-8. 2006..These findings provide direct evidence of a role for cys-LTs in regulating the initiation and/or amplification of Th2 cell-dependent pulmonary inflammation... - Distinct structural requirements of GATA-3 for the regulation of thymocyte and Th2 cell differentiationSung Yun Pai
Division of Pediatric Hematology Oncology, Children s Hospital, Department of Pediatric Oncology, Harvard Medical School, Boston, MA 02115, USA
J Immunol 180:1050-9. 2008..Taken together, our data demonstrate that the unique function of GATA-3 is conferred by both its cell type-specific expression and distinct protein structure... - Regulation of thymocyte homeostasis by Fliz1Eun Sook Hwang
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 20115, USA
Immunology 106:464-9. 2002..Taken together, our data suggest that Fliz1 plays a role in regulating thymocyte homeostasis... - The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cellsAurelie T Bauquet
Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Nat Immunol 10:167-75. 2009..Genetic loss of c-Maf resulted in a defect in IL-21 production and fewer T(H)-17 and T(FH) cells. Thus our data suggest that ICOS-induced c-Maf regulates IL-21 production that in turn regulates the expansion of T(H)-17 and T(FH) cells... - Ets-1 is a critical regulator of Ang II-mediated vascular inflammation and remodelingYumei Zhan
Division of Cardiology, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Boston, Massachusetts 02115, USA
J Clin Invest 115:2508-16. 2005..In summary, our results support a critical role for Ets-1 as a transcriptional mediator of vascular inflammation and remodeling in response to Ang II... - PTPN22.6, a dominant negative isoform of PTPN22 and potential biomarker of rheumatoid arthritisHui Hsin Chang
Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, United States of America
PLoS ONE 7:e33067. 2012..Our data depict a model that can reconcile the conflicting observations on the functional impact of the C1858T SNP and also suggest that PTPN22.6 is a novel biomarker of rheumatoid arthritis... - Ets-1 maintains IL-7 receptor expression in peripheral T cellsRoland Grenningloh
Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
J Immunol 186:969-76. 2011..Taken together, our data identify Ets-1 as a critical regulator of CD127 expression in T cells... - Role of Ets-1 phosphorylation in the effector function of Th cellsRoland Grenningloh
Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
Eur J Immunol 38:1700-5. 2008..We further demonstrate that the effect of Ets-1 phosphorylation is very modest and that full-length Ets-1 and its splice variant are functionally interchangeable in the regulation of cytokine production in Th cells... - c-Maf interacts with c-Myb to down-regulate Bcl-2 expression and increase apoptosis in peripheral CD4 cellsSiying Peng
Department of Medical Microbiology, Immunology, and Cell Biology, Southern Illinois University School of Medicine, Springfield, IL 62794, USA
Eur J Immunol 37:2868-80. 2007..These data suggest that c-Maf can interact with c-Myb to reduce Bcl-2 expression, thereby limiting CD4 cell survival following TCR engagement... - GATA-3 regulates the homeostasis and activation of CD8+ T cellsTzong Shyuan Tai
Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
J Immunol 190:428-37. 2013..More importantly, GATA-3-deficient CD8(+) T cells were less efficient in killing Ag-bearing tumor cells in vivo. Taken together, our data further expand the role of GATA-3 in T cells... - IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cellsValerie Dardalhon
Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Cambridge, Massachusetts 02139, USA
Nat Immunol 9:1347-55. 2008..Thus IL-9(+)IL-10(+) T cells lack suppressive function and constitute a distinct population of helper-effector T cells that promote tissue inflammation... - Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cellsCaroline Pot
Center for Neurologic Diseases, Brigham and Women s Hospital, Boston, MA 02115, USA
J Immunol 183:797-801. 2009..ICOS further promotes IL-27-driven Tr1 cells. Each of those elements is essential, because loss of c-Maf, IL-21-signaling, or ICOS decreases the frequency of IL-27-induced differentiation of IL-10-producing Tr1 cells... - Transcription: tantalizing times for T cellsI-Cheng Ho
Department of Immunology and Infectious Diseases, Harvard School of Public Health, 651 Huntington Avenue, FXB-2, Boston, MA 02115, USA
Cell 109:S109-20. 2002..To do so, it has evolved into two specialized subsets that direct type 1 and type 2 immunity. Here, we discuss the genetic programs that control lineage commitment of progenitor T helper cells along each of these pathways... - c-Rel delivers a one-two punch in Th1 cell differentiationSung-Yun Pai
Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA
J Clin Invest 110:741-2. 2002 - GATA-3 links tumor differentiation and dissemination in a luminal breast cancer modelHosein Kouros-Mehr
Department of Anatomy, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0452, USA
Cancer Cell 13:141-52. 2008..Rather, malignant progression occurred with an expanding GATA-3-negative tumor cell population. These data indicate that GATA-3 regulates tumor differentiation and suppresses tumor dissemination in breast cancer... - Cutting Edge: Inhibition of the retinoid X receptor (RXR) blocks T helper 2 differentiation and prevents allergic lung inflammationRoland Grenningloh
Bioxell SpA, Milan, Italy
J Immunol 176:5161-6. 2006..Th1-mediated inflammation was not affected. Its specific role in Th2-mediated inflammation makes RXR a promising target for the development of therapies against diseases such as allergic asthma and atopic dermatitis... - A stage-specific functional role of the leucine zipper transcription factor c-Maf in lung Th2 cell differentiationMichael Hausding
Laboratory of Cellular and Molecular Lung Immunology, I Medical Clinic, Mainz, Germany
Eur J Immunol 34:3401-12. 2004.... - Lipid defect underlies selective skin barrier impairment of an epidermal-specific deletion of Gata-3Cristina de Guzman Strong
National Human Genome Research Institute and 2National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
J Cell Biol 175:661-70. 2006..Comparison of these animal models illustrates how impairment of the skin barrier by two genetically distinct mechanisms leads to innate immune responses, as observed in the common human skin disorders psoriasis and atopic dermatitis...
Research Grants
- Regulation of Ets-1 activity in Th cellsI cheng Ho; Fiscal Year: 2007..The knowledge gained from the proposed experiments will allow us to develop feasible approaches to influence the function of Ets-1 and eventually lead to novel treatments of infectious and autoimmune diseases. ..
- Function and regulation of GATA-3I cheng Ho; Fiscal Year: 2007..This possibility will be addressed with several in vitro approaches (Aim 4). In addition, a great effort will be dedicated to elucidating the molecular mechanisms mediating the cell type-specific expression of GATA-3 (Aim 5). ..
- ROG--A NOVEL PROTEIN THAT REGULATES TH2 CYTOKINESI cheng Ho; Fiscal Year: 2003....