I cheng Ho

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi request reprint GATA-3 - not just for Th2 cells anymore
    I cheng Ho
    Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Cell Mol Immunol 4:15-29. 2007
  2. pmc GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation
    I cheng Ho
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Rev Immunol 9:125-35. 2009
  3. doi request reprint m(en)TOR(ing) differentiating T helper cells
    I cheng Ho
    Department of Medicine, Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Immunity 30:759-61. 2009
  4. pmc An IL-4-independent and CD25-mediated function of c-maf in promoting the production of Th2 cytokines
    Eun Sook Hwang
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 99:13026-30. 2002
  5. ncbi request reprint GATA-3 regulates the development and function of invariant NKT cells
    Peter J Kim
    Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Immunol 177:6650-9. 2006
  6. ncbi request reprint A repressor of GATA-mediated negative feedback mechanism of T cell activation
    Shi Chuen Miaw
    Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 172:170-7. 2004
  7. ncbi request reprint Transcriptional regulation of GATA-3 by an intronic regulatory region and fetal liver zinc finger protein 1
    Eun Sook Hwang
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    J Immunol 169:248-53. 2002
  8. ncbi request reprint Transcription: tantalizing times for T cells
    I cheng Ho
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, 651 Huntington Avenue, FXB 2, Boston, MA 02115, USA
    Cell 109:S109-20. 2002
  9. pmc Ets-1 is a negative regulator of Th17 differentiation
    Jacques Moisan
    Rheumatology, Immunology and Allergy, Brigham and Women s Hospital Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 204:2825-35. 2007
  10. pmc ROG negatively regulates T-cell activation but is dispensable for Th-cell differentiation
    Bok Yun Kang
    Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Brigham and Women s HospitalSmith Building, Room 524, One Jimmy Fund Way, Boston, MA 02115, USA
    Mol Cell Biol 25:554-62. 2005

Research Grants

  1. Regulation of Ets-1 activity in Th cells
    I cheng Ho; Fiscal Year: 2007
  2. Function and regulation of GATA-3
    I cheng Ho; Fiscal Year: 2007
  3. ROG--A NOVEL PROTEIN THAT REGULATES TH2 CYTOKINES
    I cheng Ho; Fiscal Year: 2003

Collaborators

Detail Information

Publications31

  1. ncbi request reprint GATA-3 - not just for Th2 cells anymore
    I cheng Ho
    Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Cell Mol Immunol 4:15-29. 2007
    ..Not only does GATA-3 participate in nearly every stage of T cell development from common lymphoid progenitor to Th2, conditional knockout studies have indicated that the influence of GATA-3 also extends beyond the immune system...
  2. pmc GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation
    I cheng Ho
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Rev Immunol 9:125-35. 2009
    ..In addition, we discuss the interactions between GATA3 and other transcription factors and signalling pathways, and highlight the functional significance of the GATA3 protein structure...
  3. doi request reprint m(en)TOR(ing) differentiating T helper cells
    I cheng Ho
    Department of Medicine, Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Immunity 30:759-61. 2009
    ..In this issue of Immunity, Delgoffe et al. (2009) use genetic approaches and demonstrate that mTOR kinase plays a critical role in this decision-making process...
  4. pmc An IL-4-independent and CD25-mediated function of c-maf in promoting the production of Th2 cytokines
    Eun Sook Hwang
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 99:13026-30. 2002
    ..Taken together, our results uncover an IL-4-independent and CD25-mediated function of c-maf in promoting the production of Th2 cytokines...
  5. ncbi request reprint GATA-3 regulates the development and function of invariant NKT cells
    Peter J Kim
    Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Immunol 177:6650-9. 2006
    ..In addition, GATA-3 is also required for survival, activation, and effector functions of this unique population of T cells. Our data also reveal a previously unidentified peripheral maturation step that is GATA-3 dependent...
  6. ncbi request reprint A repressor of GATA-mediated negative feedback mechanism of T cell activation
    Shi Chuen Miaw
    Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 172:170-7. 2004
    ..Restoration of ROG expression in vivo partly corrects the hyperproliferation of NF-ATc2-deficient Th cells by attenuating TCR signals. Our data, therefore, depict a ROG-mediated negative feedback mechanism of T cell activation...
  7. ncbi request reprint Transcriptional regulation of GATA-3 by an intronic regulatory region and fetal liver zinc finger protein 1
    Eun Sook Hwang
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    J Immunol 169:248-53. 2002
    ..Our data suggest that the expression of GATA-3 might be partly regulated by the intronic regulatory region and Fliz1 in a developmental stage-specific fashion...
  8. ncbi request reprint Transcription: tantalizing times for T cells
    I cheng Ho
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, 651 Huntington Avenue, FXB 2, Boston, MA 02115, USA
    Cell 109:S109-20. 2002
    ..To do so, it has evolved into two specialized subsets that direct type 1 and type 2 immunity. Here, we discuss the genetic programs that control lineage commitment of progenitor T helper cells along each of these pathways...
  9. pmc Ets-1 is a negative regulator of Th17 differentiation
    Jacques Moisan
    Rheumatology, Immunology and Allergy, Brigham and Women s Hospital Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 204:2825-35. 2007
    ..Based on these observations, we report that Ets-1 is a negative regulator of Th17 differentiation...
  10. pmc ROG negatively regulates T-cell activation but is dispensable for Th-cell differentiation
    Bok Yun Kang
    Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Brigham and Women s HospitalSmith Building, Room 524, One Jimmy Fund Way, Boston, MA 02115, USA
    Mol Cell Biol 25:554-62. 2005
    ..Its mechanism of action and its expression pattern are distinct from those of other transcription factors negatively regulating the activation of T cells...
  11. pmc GATA-3 deficiency abrogates the development and maintenance of T helper type 2 cells
    Sung Yun Pai
    Department of Pediatric Hematology Oncology, Dana Farber Cancer Institute and Children s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 101:1993-8. 2004
    ..Using a conditional knockout approach, we found that GATA-3 is required for optimal Th2 cytokine production in vitro and in vivo. Our data also show that GATA-3 expression must be sustained to maintain the Th2 phenotype...
  12. pmc Ets-1, a functional cofactor of T-bet, is essential for Th1 inflammatory responses
    Roland Grenningloh
    Department of Medicine, Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Exp Med 201:615-26. 2005
    ..In addition, Ets-1-deficient Th1 cells also produce a very high level of interleukin 10. Thus, Ets-1 plays a crucial and unique role in the reciprocal regulation of inflammatory and antiinflammatory Th responses...
  13. ncbi request reprint Cysteinyl leukotrienes regulate Th2 cell-dependent pulmonary inflammation
    Daniel C Kim
    Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 176:4440-8. 2006
    ..These findings provide direct evidence of a role for cys-LTs in regulating the initiation and/or amplification of Th2 cell-dependent pulmonary inflammation...
  14. ncbi request reprint Critical roles for transcription factor GATA-3 in thymocyte development
    Sung Yun Pai
    Department of Pediatric Hematology Oncology, Dana Farber Cancer Institute and Children s Hospital, Boston, MA 02115, USA
    Immunity 19:863-75. 2003
    ..Thus, our data demonstrate that the coordinated and regulated expression of GATA-3 at each stage of thymic development is critical for the generation of mature T cells...
  15. pmc c-Rel delivers a one-two punch in Th1 cell differentiation
    Sung Yun Pai
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, USA
    J Clin Invest 110:741-2. 2002
  16. ncbi request reprint Distinct structural requirements of GATA-3 for the regulation of thymocyte and Th2 cell differentiation
    Sung Yun Pai
    Division of Pediatric Hematology Oncology, Children s Hospital, Department of Pediatric Oncology, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 180:1050-9. 2008
    ..Taken together, our data demonstrate that the unique function of GATA-3 is conferred by both its cell type-specific expression and distinct protein structure...
  17. pmc Regulation of thymocyte homeostasis by Fliz1
    Eun Sook Hwang
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 20115, USA
    Immunology 106:464-9. 2002
    ..Taken together, our data suggest that Fliz1 plays a role in regulating thymocyte homeostasis...
  18. pmc GATA-3 regulates the homeostasis and activation of CD8+ T cells
    Tzong Shyuan Tai
    Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Immunol 190:428-37. 2013
    ..More importantly, GATA-3-deficient CD8(+) T cells were less efficient in killing Ag-bearing tumor cells in vivo. Taken together, our data further expand the role of GATA-3 in T cells...
  19. pmc The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells
    Aurelie T Bauquet
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Immunol 10:167-75. 2009
    ..Genetic loss of c-Maf resulted in a defect in IL-21 production and fewer T(H)-17 and T(FH) cells. Thus our data suggest that ICOS-induced c-Maf regulates IL-21 production that in turn regulates the expansion of T(H)-17 and T(FH) cells...
  20. pmc Ets-1 is a critical regulator of Ang II-mediated vascular inflammation and remodeling
    Yumei Zhan
    Division of Cardiology, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Boston, Massachusetts 02115, USA
    J Clin Invest 115:2508-16. 2005
    ..In summary, our results support a critical role for Ets-1 as a transcriptional mediator of vascular inflammation and remodeling in response to Ang II...
  21. pmc PTPN22.6, a dominant negative isoform of PTPN22 and potential biomarker of rheumatoid arthritis
    Hui Hsin Chang
    Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 7:e33067. 2012
    ..Our data depict a model that can reconcile the conflicting observations on the functional impact of the C1858T SNP and also suggest that PTPN22.6 is a novel biomarker of rheumatoid arthritis...
  22. pmc Ets-1 maintains IL-7 receptor expression in peripheral T cells
    Roland Grenningloh
    Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Immunol 186:969-76. 2011
    ..Taken together, our data identify Ets-1 as a critical regulator of CD127 expression in T cells...
  23. doi request reprint Role of Ets-1 phosphorylation in the effector function of Th cells
    Roland Grenningloh
    Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Eur J Immunol 38:1700-5. 2008
    ..We further demonstrate that the effect of Ets-1 phosphorylation is very modest and that full-length Ets-1 and its splice variant are functionally interchangeable in the regulation of cytokine production in Th cells...
  24. ncbi request reprint c-Maf interacts with c-Myb to down-regulate Bcl-2 expression and increase apoptosis in peripheral CD4 cells
    Siying Peng
    Department of Medical Microbiology, Immunology, and Cell Biology, Southern Illinois University School of Medicine, Springfield, IL 62794, USA
    Eur J Immunol 37:2868-80. 2007
    ..These data suggest that c-Maf can interact with c-Myb to reduce Bcl-2 expression, thereby limiting CD4 cell survival following TCR engagement...
  25. doi request reprint PTPN22 Modulates Macrophage Polarization and Susceptibility to Dextran Sulfate Sodium-Induced Colitis
    Hui Hsin Chang
    Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115
    J Immunol 191:2134-43. 2013
    ..Our data not only demonstrate a critical role of PTPN22 in regulating macrophage polarization but also provide a molecular explanation for the protective effect of the C1858T SNP in Crohn's disease. ..
  26. pmc IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells
    Valerie Dardalhon
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Cambridge, Massachusetts 02139, USA
    Nat Immunol 9:1347-55. 2008
    ..Thus IL-9(+)IL-10(+) T cells lack suppressive function and constitute a distinct population of helper-effector T cells that promote tissue inflammation...
  27. pmc Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells
    Caroline Pot
    Center for Neurologic Diseases, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Immunol 183:797-801. 2009
    ..ICOS further promotes IL-27-driven Tr1 cells. Each of those elements is essential, because loss of c-Maf, IL-21-signaling, or ICOS decreases the frequency of IL-27-induced differentiation of IL-10-producing Tr1 cells...
  28. pmc GATA-3 links tumor differentiation and dissemination in a luminal breast cancer model
    Hosein Kouros-Mehr
    Department of Anatomy, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0452, USA
    Cancer Cell 13:141-52. 2008
    ..Rather, malignant progression occurred with an expanding GATA-3-negative tumor cell population. These data indicate that GATA-3 regulates tumor differentiation and suppresses tumor dissemination in breast cancer...
  29. ncbi request reprint Cutting Edge: Inhibition of the retinoid X receptor (RXR) blocks T helper 2 differentiation and prevents allergic lung inflammation
    Roland Grenningloh
    Bioxell SpA, Milan, Italy
    J Immunol 176:5161-6. 2006
    ..Th1-mediated inflammation was not affected. Its specific role in Th2-mediated inflammation makes RXR a promising target for the development of therapies against diseases such as allergic asthma and atopic dermatitis...
  30. ncbi request reprint A stage-specific functional role of the leucine zipper transcription factor c-Maf in lung Th2 cell differentiation
    Michael Hausding
    Laboratory of Cellular and Molecular Lung Immunology, I Medical Clinic, Mainz, Germany
    Eur J Immunol 34:3401-12. 2004
    ....
  31. pmc Lipid defect underlies selective skin barrier impairment of an epidermal-specific deletion of Gata-3
    Cristina de Guzman Strong
    National Human Genome Research Institute and 2National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Biol 175:661-70. 2006
    ..Comparison of these animal models illustrates how impairment of the skin barrier by two genetically distinct mechanisms leads to innate immune responses, as observed in the common human skin disorders psoriasis and atopic dermatitis...

Research Grants11

  1. Regulation of Ets-1 activity in Th cells
    I cheng Ho; Fiscal Year: 2007
    ..The knowledge gained from the proposed experiments will allow us to develop feasible approaches to influence the function of Ets-1 and eventually lead to novel treatments of infectious and autoimmune diseases. ..
  2. Function and regulation of GATA-3
    I cheng Ho; Fiscal Year: 2007
    ..This possibility will be addressed with several in vitro approaches (Aim 4). In addition, a great effort will be dedicated to elucidating the molecular mechanisms mediating the cell type-specific expression of GATA-3 (Aim 5). ..
  3. ROG--A NOVEL PROTEIN THAT REGULATES TH2 CYTOKINES
    I cheng Ho; Fiscal Year: 2003
    ....