Carolyn Y Ho

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc T1 measurements identify extracellular volume expansion in hypertrophic cardiomyopathy sarcomere mutation carriers with and without left ventricular hypertrophy
    Carolyn Y Ho
    Cardiovascular Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    Circ Cardiovasc Imaging 6:415-22. 2013
  2. pmc Genetic considerations in hypertrophic cardiomyopathy
    Carolyn Y Ho
    Cardiovascular Division, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    Prog Cardiovasc Dis 54:456-60. 2012
  3. pmc The diagnosis of hypertrophic cardiomyopathy by cardiovascular magnetic resonance
    Radwa A Noureldin
    Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, MD, USA
    J Cardiovasc Magn Reson 14:17. 2012
  4. ncbi request reprint [Clinical spectrum of preclinical hypertrophic cardiomyopathy: characterizing carriers of sarcomere gene mutation]
    Carolyn Y Ho
    Cardiovascular Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    Zhonghua Xin Xue Guan Bing Za Zhi 37:289-93. 2009
  5. ncbi request reprint A contemporary approach to hypertrophic cardiomyopathy
    Carolyn Y Ho
    Cardiovascular Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    Circulation 113:e858-62. 2006
  6. pmc Hypertrophic cardiomyopathy
    Carolyn Y Ho
    Cardiovascular Division, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Heart Fail Clin 6:141-59. 2010
  7. doi request reprint Hypertrophic cardiomyopathy: preclinical and early phenotype
    Carolyn Y Ho
    Cardiovascular Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Cardiovasc Transl Res 2:462-70. 2009
  8. pmc Myocardial fibrosis as an early manifestation of hypertrophic cardiomyopathy
    Carolyn Y Ho
    Cardiovascular Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    N Engl J Med 363:552-63. 2010
  9. pmc Echocardiographic strain imaging to assess early and late consequences of sarcomere mutations in hypertrophic cardiomyopathy
    Carolyn Y Ho
    Cardiovascular Division, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Circ Cardiovasc Genet 2:314-21. 2009
  10. pmc Subtle abnormalities in contractile function are an early manifestation of sarcomere mutations in dilated cardiomyopathy
    Neal K Lakdawala
    Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Circ Cardiovasc Genet 5:503-10. 2012

Research Grants

Collaborators

Detail Information

Publications23

  1. pmc T1 measurements identify extracellular volume expansion in hypertrophic cardiomyopathy sarcomere mutation carriers with and without left ventricular hypertrophy
    Carolyn Y Ho
    Cardiovascular Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    Circ Cardiovasc Imaging 6:415-22. 2013
    ..To further evaluate these processes, we used cardiac magnetic resonance with T1 measurements on a genotyped HCM population to quantify myocardial extracellular volume (ECV)...
  2. pmc Genetic considerations in hypertrophic cardiomyopathy
    Carolyn Y Ho
    Cardiovascular Division, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    Prog Cardiovasc Dis 54:456-60. 2012
    ..This provides a definitive means to identify at-risk relatives, as well as new opportunities to study pathogenesis, and developing novel strategies for disease prevention and modification...
  3. pmc The diagnosis of hypertrophic cardiomyopathy by cardiovascular magnetic resonance
    Radwa A Noureldin
    Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, MD, USA
    J Cardiovasc Magn Reson 14:17. 2012
    ..It is likely that integrating genetic advances with enhanced phenotypic characterization of HCM with novel CMR techniques will importantly improve our understanding of this complex disease...
  4. ncbi request reprint [Clinical spectrum of preclinical hypertrophic cardiomyopathy: characterizing carriers of sarcomere gene mutation]
    Carolyn Y Ho
    Cardiovascular Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    Zhonghua Xin Xue Guan Bing Za Zhi 37:289-93. 2009
    ..By studying this intriguing preclinical cohort, we can better understand the early stages of disease pathogenesis and potentially develop therapy to alter the clinical expression of sarcomere mutations...
  5. ncbi request reprint A contemporary approach to hypertrophic cardiomyopathy
    Carolyn Y Ho
    Cardiovascular Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    Circulation 113:e858-62. 2006
  6. pmc Hypertrophic cardiomyopathy
    Carolyn Y Ho
    Cardiovascular Division, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Heart Fail Clin 6:141-59. 2010
    ....
  7. doi request reprint Hypertrophic cardiomyopathy: preclinical and early phenotype
    Carolyn Y Ho
    Cardiovascular Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Cardiovasc Transl Res 2:462-70. 2009
    ....
  8. pmc Myocardial fibrosis as an early manifestation of hypertrophic cardiomyopathy
    Carolyn Y Ho
    Cardiovascular Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    N Engl J Med 363:552-63. 2010
    ..In animal models, profibrotic genetic pathways are activated early, before hypertrophic remodeling. Data showing early profibrotic responses to sarcomere-gene mutations in patients with hypertrophic cardiomyopathy are lacking...
  9. pmc Echocardiographic strain imaging to assess early and late consequences of sarcomere mutations in hypertrophic cardiomyopathy
    Carolyn Y Ho
    Cardiovascular Division, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Circ Cardiovasc Genet 2:314-21. 2009
    ..Previous studies demonstrated that impaired relaxation develops before left ventricular hypertrophy (LVH). The precise impact of sarcomere mutations on systolic function in early and late disease is unclear...
  10. pmc Subtle abnormalities in contractile function are an early manifestation of sarcomere mutations in dilated cardiomyopathy
    Neal K Lakdawala
    Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Circ Cardiovasc Genet 5:503-10. 2012
    ..By studying mutation carriers before a clinical diagnosis develops, we characterize the early manifestations of sarcomere mutations in DCM and investigate how these manifestations differ from sarcomere mutations associated with HCM...
  11. pmc Electrocardiographic features of sarcomere mutation carriers with and without clinically overt hypertrophic cardiomyopathy
    Neal K Lakdawala
    Cardiovascular Division, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Am J Cardiol 108:1606-13. 2011
    ..However, owing to the limited sensitivity of ECG and echocardiographic screening, genetic testing is required to definitively identify at-risk family members...
  12. ncbi request reprint Novel locus for an inherited cardiomyopathy maps to chromosome 7
    Lei Song
    Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Boston, MA, USA
    Circulation 113:2186-92. 2006
    ..To add further complexity, other genetic origins can mimic the gross clinical phenotype of HCM, and mutations in sarcomere genes have been demonstrated to cause dilated cardiomyopathy...
  13. ncbi request reprint Gene mutations in apical hypertrophic cardiomyopathy
    Michael Arad
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Circulation 112:2805-11. 2005
    ..The genetic relationship between HCM with typical hypertrophic morphology versus isolated apical hypertrophy is incompletely understood...
  14. pmc Familial dilated cardiomyopathy caused by an alpha-tropomyosin mutation: the distinctive natural history of sarcomeric dilated cardiomyopathy
    Neal K Lakdawala
    Cardiovascular Division, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Am Coll Cardiol 55:320-9. 2010
    ..We sought to further define the role of sarcomere mutations in dilated cardiomyopathy (DCM) and associated clinical phenotypes...
  15. ncbi request reprint A clinician's guide to tissue Doppler imaging
    Carolyn Y Ho
    Cardiovascular Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    Circulation 113:e396-8. 2006
  16. pmc Genetic testing for dilated cardiomyopathy in clinical practice
    Neal K Lakdawala
    Cardiovascular Division, Brigham and Women s Hospital, Boston, Massachusetts, USA
    J Card Fail 18:296-303. 2012
    ..However, the role of genetic testing in clinical practice is not well defined. We examined the experience of clinical genetic testing in a diverse DCM population to characterize the prevalence and predictors of gene mutations...
  17. ncbi request reprint Assessment of diastolic function with Doppler tissue imaging to predict genotype in preclinical hypertrophic cardiomyopathy
    Carolyn Y Ho
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Circulation 105:2992-7. 2002
    ..Altered diastolic function has been hypothesized to represent an earlier manifestation of HCM before the development of LVH; however, data regarding the clinical utility of imaging techniques that assess this parameter are limited...
  18. ncbi request reprint Genetic testing in cardiac disease: from bench to bedside
    Allison L Cirino
    Cardiovascular Genetics Center of the Cardiovascular Division, Brigham and Women s Hospital, Boston, MA, USA
    Nat Clin Pract Cardiovasc Med 3:462-3. 2006
  19. doi request reprint Comparison of echocardiographic and cardiac magnetic resonance imaging in hypertrophic cardiomyopathy sarcomere mutation carriers without left ventricular hypertrophy
    Anne Marie Valente
    Cardiovascular Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    Circ Cardiovasc Genet 6:230-7. 2013
    ..However, the incremental advantage offered by CMR for early diagnosis of hypertrophic cardiomyopathy is unclear. Therefore, we systematically compared echo and CMR in G+/LVH- subjects...
  20. pmc Truncations of titin causing dilated cardiomyopathy
    Daniel S Herman
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    N Engl J Med 366:619-28. 2012
    ..Dilated cardiomyopathy and hypertrophic cardiomyopathy arise from mutations in many genes. TTN, the gene encoding the sarcomere protein titin, has been insufficiently analyzed for cardiomyopathy mutations because of its enormous size...
  21. doi request reprint Handheld echocardiography offers rapid assessment of clinical volume status
    Viviane T Q Nguyen
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Am Heart J 156:537-42. 2008
    ..In this study, we evaluated the feasibility and accuracy of handheld echocardiography by a nonexpert for potential use in the point of care evaluation of compensation...
  22. pmc Cardiovascular manifestations of Fabry disease: relationships between left ventricular hypertrophy, disease severity, and alpha-galactosidase A activity
    Justina C Wu
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Eur Heart J 31:1088-97. 2010
    ..This study analysed the cardiovascular manifestations of a cohort of Fabry patients, and sought to define relationships between disease severity, alphagal activity, and cardiac abnormalities...
  23. ncbi request reprint Heart failure and genomics
    Daniel P Judge
    J Am Coll Cardiol 49:1106; author reply 1106-7. 2007

Research Grants3

  1. Diastolic Function in Hypertrophic Cardiomyopathy
    Carolyn Ho; Fiscal Year: 2003
    ..Such genotype-phenotype correlations have the potential to improve our ability to risk stratify and monitor patients, and may ultimately inspire noel approaches to management. ..
  2. Diagnostic and Treatment Strategies for Preclinical HCM
    Carolyn Ho; Fiscal Year: 2007
    ..abstract_text> ..