Carolyn Y Ho

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc Diltiazem treatment for pre-clinical hypertrophic cardiomyopathy sarcomere mutation carriers: a pilot randomized trial to modify disease expression
    Carolyn Y Ho
    Cardiovascular Division, Brigham and Women s Hospital, Boston, Massachusetts Electronic address
    JACC Heart Fail 3:180-8. 2015
  2. pmc The MedSeq Project: a randomized trial of integrating whole genome sequencing into clinical medicine
    Jason L Vassy
    Genomes2People and Division of Genetics, Department of Medicine, Brigham and Women s Hospital, Broad Institute and Harvard Medical School, 41 Avenue Louis Pasteur, Suite 301, 02115 Boston, MA, USA
    Trials 15:85. 2014
  3. pmc T1 measurements identify extracellular volume expansion in hypertrophic cardiomyopathy sarcomere mutation carriers with and without left ventricular hypertrophy
    Carolyn Y Ho
    Cardiovascular Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    Circ Cardiovasc Imaging 6:415-22. 2013
  4. pmc Genetic considerations in hypertrophic cardiomyopathy
    Carolyn Y Ho
    Cardiovascular Division, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    Prog Cardiovasc Dis 54:456-60. 2012
  5. pmc The diagnosis of hypertrophic cardiomyopathy by cardiovascular magnetic resonance
    Radwa A Noureldin
    Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, MD, USA
    J Cardiovasc Magn Reson 14:17. 2012
  6. pmc Myocardial fibrosis as an early manifestation of hypertrophic cardiomyopathy
    Carolyn Y Ho
    Cardiovascular Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    N Engl J Med 363:552-63. 2010
  7. doi request reprint Hypertrophic cardiomyopathy: preclinical and early phenotype
    Carolyn Y Ho
    Cardiovascular Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Cardiovasc Transl Res 2:462-70. 2009
  8. pmc Hypertrophic cardiomyopathy
    Carolyn Y Ho
    Cardiovascular Division, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Heart Fail Clin 6:141-59. 2010
  9. pmc Echocardiographic strain imaging to assess early and late consequences of sarcomere mutations in hypertrophic cardiomyopathy
    Carolyn Y Ho
    Cardiovascular Division, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Circ Cardiovasc Genet 2:314-21. 2009
  10. ncbi request reprint [Clinical spectrum of preclinical hypertrophic cardiomyopathy: characterizing carriers of sarcomere gene mutation]
    Carolyn Y Ho
    Cardiovascular Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    Zhonghua Xin Xue Guan Bing Za Zhi 37:289-93. 2009

Research Grants

Collaborators

Detail Information

Publications25

  1. pmc Diltiazem treatment for pre-clinical hypertrophic cardiomyopathy sarcomere mutation carriers: a pilot randomized trial to modify disease expression
    Carolyn Y Ho
    Cardiovascular Division, Brigham and Women s Hospital, Boston, Massachusetts Electronic address
    JACC Heart Fail 3:180-8. 2015
    ..The study sought to assess the safety, feasibility, and effect of diltiazem as disease-modifying therapy for at-risk hypertrophic cardiomyopathy (HCM) mutation carriers...
  2. pmc The MedSeq Project: a randomized trial of integrating whole genome sequencing into clinical medicine
    Jason L Vassy
    Genomes2People and Division of Genetics, Department of Medicine, Brigham and Women s Hospital, Broad Institute and Harvard Medical School, 41 Avenue Louis Pasteur, Suite 301, 02115 Boston, MA, USA
    Trials 15:85. 2014
    ..It is also unknown how best to communicate sequencing results to physicians and patients to improve health. We describe the design of the MedSeq Project: the first randomized trials of WGS in clinical care...
  3. pmc T1 measurements identify extracellular volume expansion in hypertrophic cardiomyopathy sarcomere mutation carriers with and without left ventricular hypertrophy
    Carolyn Y Ho
    Cardiovascular Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    Circ Cardiovasc Imaging 6:415-22. 2013
    ..To further evaluate these processes, we used cardiac magnetic resonance with T1 measurements on a genotyped HCM population to quantify myocardial extracellular volume (ECV)...
  4. pmc Genetic considerations in hypertrophic cardiomyopathy
    Carolyn Y Ho
    Cardiovascular Division, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    Prog Cardiovasc Dis 54:456-60. 2012
    ..This provides a definitive means to identify at-risk relatives, as well as new opportunities to study pathogenesis, and developing novel strategies for disease prevention and modification...
  5. pmc The diagnosis of hypertrophic cardiomyopathy by cardiovascular magnetic resonance
    Radwa A Noureldin
    Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, MD, USA
    J Cardiovasc Magn Reson 14:17. 2012
    ..It is likely that integrating genetic advances with enhanced phenotypic characterization of HCM with novel CMR techniques will importantly improve our understanding of this complex disease...
  6. pmc Myocardial fibrosis as an early manifestation of hypertrophic cardiomyopathy
    Carolyn Y Ho
    Cardiovascular Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    N Engl J Med 363:552-63. 2010
    ..In animal models, profibrotic genetic pathways are activated early, before hypertrophic remodeling. Data showing early profibrotic responses to sarcomere-gene mutations in patients with hypertrophic cardiomyopathy are lacking...
  7. doi request reprint Hypertrophic cardiomyopathy: preclinical and early phenotype
    Carolyn Y Ho
    Cardiovascular Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Cardiovasc Transl Res 2:462-70. 2009
    ....
  8. pmc Hypertrophic cardiomyopathy
    Carolyn Y Ho
    Cardiovascular Division, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Heart Fail Clin 6:141-59. 2010
    ....
  9. pmc Echocardiographic strain imaging to assess early and late consequences of sarcomere mutations in hypertrophic cardiomyopathy
    Carolyn Y Ho
    Cardiovascular Division, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Circ Cardiovasc Genet 2:314-21. 2009
    ..Previous studies demonstrated that impaired relaxation develops before left ventricular hypertrophy (LVH). The precise impact of sarcomere mutations on systolic function in early and late disease is unclear...
  10. ncbi request reprint [Clinical spectrum of preclinical hypertrophic cardiomyopathy: characterizing carriers of sarcomere gene mutation]
    Carolyn Y Ho
    Cardiovascular Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    Zhonghua Xin Xue Guan Bing Za Zhi 37:289-93. 2009
    ..By studying this intriguing preclinical cohort, we can better understand the early stages of disease pathogenesis and potentially develop therapy to alter the clinical expression of sarcomere mutations...
  11. ncbi request reprint A contemporary approach to hypertrophic cardiomyopathy
    Carolyn Y Ho
    Cardiovascular Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    Circulation 113:e858-62. 2006
  12. pmc Subtle abnormalities in contractile function are an early manifestation of sarcomere mutations in dilated cardiomyopathy
    Neal K Lakdawala
    Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Circ Cardiovasc Genet 5:503-10. 2012
    ..By studying mutation carriers before a clinical diagnosis develops, we characterize the early manifestations of sarcomere mutations in DCM and investigate how these manifestations differ from sarcomere mutations associated with HCM...
  13. pmc Electrocardiographic features of sarcomere mutation carriers with and without clinically overt hypertrophic cardiomyopathy
    Neal K Lakdawala
    Cardiovascular Division, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Am J Cardiol 108:1606-13. 2011
    ..However, owing to the limited sensitivity of ECG and echocardiographic screening, genetic testing is required to definitively identify at-risk family members...
  14. pmc Comparison of echocardiographic and cardiac magnetic resonance imaging in hypertrophic cardiomyopathy sarcomere mutation carriers without left ventricular hypertrophy
    Anne Marie Valente
    Cardiovascular Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    Circ Cardiovasc Genet 6:230-7. 2013
    ..However, the incremental advantage offered by CMR for early diagnosis of hypertrophic cardiomyopathy is unclear. Therefore, we systematically compared echo and CMR in G+/LVH- subjects...
  15. pmc Familial dilated cardiomyopathy caused by an alpha-tropomyosin mutation: the distinctive natural history of sarcomeric dilated cardiomyopathy
    Neal K Lakdawala
    Cardiovascular Division, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Am Coll Cardiol 55:320-9. 2010
    ..We sought to further define the role of sarcomere mutations in dilated cardiomyopathy (DCM) and associated clinical phenotypes...
  16. ncbi request reprint Gene mutations in apical hypertrophic cardiomyopathy
    Michael Arad
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Circulation 112:2805-11. 2005
    ..The genetic relationship between HCM with typical hypertrophic morphology versus isolated apical hypertrophy is incompletely understood...
  17. ncbi request reprint Novel locus for an inherited cardiomyopathy maps to chromosome 7
    Lei Song
    Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Boston, MA, USA
    Circulation 113:2186-92. 2006
    ..To add further complexity, other genetic origins can mimic the gross clinical phenotype of HCM, and mutations in sarcomere genes have been demonstrated to cause dilated cardiomyopathy...
  18. ncbi request reprint A clinician's guide to tissue Doppler imaging
    Carolyn Y Ho
    Cardiovascular Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    Circulation 113:e396-8. 2006
  19. pmc Genetic testing for dilated cardiomyopathy in clinical practice
    Neal K Lakdawala
    Cardiovascular Division, Brigham and Women s Hospital, Boston, Massachusetts, USA
    J Card Fail 18:296-303. 2012
    ..However, the role of genetic testing in clinical practice is not well defined. We examined the experience of clinical genetic testing in a diverse DCM population to characterize the prevalence and predictors of gene mutations...
  20. ncbi request reprint Genetic testing in cardiac disease: from bench to bedside
    Allison L Cirino
    Cardiovascular Genetics Center of the Cardiovascular Division, Brigham and Women s Hospital, Boston, MA, USA
    Nat Clin Pract Cardiovasc Med 3:462-3. 2006
  21. ncbi request reprint Assessment of diastolic function with Doppler tissue imaging to predict genotype in preclinical hypertrophic cardiomyopathy
    Carolyn Y Ho
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Circulation 105:2992-7. 2002
    ..Altered diastolic function has been hypothesized to represent an earlier manifestation of HCM before the development of LVH; however, data regarding the clinical utility of imaging techniques that assess this parameter are limited...
  22. pmc Truncations of titin causing dilated cardiomyopathy
    Daniel S Herman
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    N Engl J Med 366:619-28. 2012
    ..Dilated cardiomyopathy and hypertrophic cardiomyopathy arise from mutations in many genes. TTN, the gene encoding the sarcomere protein titin, has been insufficiently analyzed for cardiomyopathy mutations because of its enormous size...
  23. doi request reprint Handheld echocardiography offers rapid assessment of clinical volume status
    Viviane T Q Nguyen
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Am Heart J 156:537-42. 2008
    ..In this study, we evaluated the feasibility and accuracy of handheld echocardiography by a nonexpert for potential use in the point of care evaluation of compensation...
  24. pmc Cardiovascular manifestations of Fabry disease: relationships between left ventricular hypertrophy, disease severity, and alpha-galactosidase A activity
    Justina C Wu
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Eur Heart J 31:1088-97. 2010
    ..This study analysed the cardiovascular manifestations of a cohort of Fabry patients, and sought to define relationships between disease severity, alphagal activity, and cardiac abnormalities...
  25. ncbi request reprint Heart failure and genomics
    Daniel P Judge
    J Am Coll Cardiol 49:1106; author reply 1106-7. 2007

Research Grants1

  1. Diastolic Function in Hypertrophic Cardiomyopathy
    Carolyn Ho; Fiscal Year: 2003
    ..Such genotype-phenotype correlations have the potential to improve our ability to risk stratify and monitor patients, and may ultimately inspire noel approaches to management. ..