J N Hirschhorn

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. pmc Genomewide linkage analysis of stature in multiple populations reveals several regions with evidence of linkage to adult height
    J N Hirschhorn
    Whitehead MIT Center for Genome Research, One Kendall Square, Cambridge, MA 02139, USA
    Am J Hum Genet 69:106-16. 2001
  2. ncbi request reprint Large-scale discovery and genotyping of single-nucleotide polymorphisms in the mouse
    K Lindblad-Toh
    Whitehead Institute MIT Center for Genome Research, Whitehead Institute for Biomedical Research, Cambridge, MA, USA
    Nat Genet 24:381-6. 2000
  3. ncbi request reprint The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes
    D Altshuler
    Whitehead Institute MIT Center for Genome Research, Cambridge, Massachusetts, USA
    Nat Genet 26:76-80. 2000
  4. ncbi request reprint Association testing of common variants in the insulin receptor substrate-1 gene (IRS1) with type 2 diabetes
    J C Florez
    Simches Research Building CPZN 6820, Diabetes Unit Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
    Diabetologia 50:1209-17. 2007

Collaborators

Detail Information

Publications4

  1. pmc Genomewide linkage analysis of stature in multiple populations reveals several regions with evidence of linkage to adult height
    J N Hirschhorn
    Whitehead MIT Center for Genome Research, One Kendall Square, Cambridge, MA 02139, USA
    Am J Hum Genet 69:106-16. 2001
    ..These studies suggest that highly heritable complex traits such as stature may be genetically tractable and provide insight into the genetic architecture of complex traits...
  2. ncbi request reprint Large-scale discovery and genotyping of single-nucleotide polymorphisms in the mouse
    K Lindblad-Toh
    Whitehead Institute MIT Center for Genome Research, Whitehead Institute for Biomedical Research, Cambridge, MA, USA
    Nat Genet 24:381-6. 2000
    ..We have also developed a multiplex genotyping procedure by which a genome scan can be performed with only six genotyping reactions per animal...
  3. ncbi request reprint The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes
    D Altshuler
    Whitehead Institute MIT Center for Genome Research, Cambridge, Massachusetts, USA
    Nat Genet 26:76-80. 2000
    ..Because the risk allele occurs at such high frequency, its modest effect translates into a large population attributable risk-influencing as much as 25% of type 2 diabetes in the general population...
  4. ncbi request reprint Association testing of common variants in the insulin receptor substrate-1 gene (IRS1) with type 2 diabetes
    J C Florez
    Simches Research Building CPZN 6820, Diabetes Unit Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
    Diabetologia 50:1209-17. 2007
    ..However, other nearby variants might account for the putative association signal...