Affiliation: Massachusetts General Hospital
- Large brains in autism: the challenge of pervasive abnormalityMartha R Herbert
Pediatric Neurology, Center for Morphometric Analysis, Massachusetts General Hospital, Charleston, MA 02129, USA
Neuroscientist 11:417-40. 2005..This convergence of findings and models suggests that a systems- and chronic disease-based reformulation of function and pathophysiology in autism needs to be considered, and it opens the possibility for new treatment targets...
- Offering to share: how to put heads together in autism neuroimagingMatthew K Belmonte
Department of Human Development, Cornell University, Martha Van Rensselaer Hall, Ithaca, NY 14853 4401, USA
J Autism Dev Disord 38:2-13. 2008..A theme in these requirements is the need to preserve creative approaches and risk-taking within individual laboratories at the same time as common standards are provided for these laboratories to build on...
- Abnormal asymmetry in language association cortex in autismMartha R Herbert
Center for Morphometric Analysis, Massachusetts General Hospital, CNY 149, Room 6012, Boston, MA 02114, USA
Ann Neurol 52:588-96. 2002..In boys with autism, language and social/face processing-related regions displayed abnormal asymmetry. These structural abnormalities may relate to language and social disturbances observed in autism...
- Brain abnormalities in language disorders and in autismMartha R Herbert
Department of Neurology, Massachusetts General Hospital, MGH Martinos, CNY 149 6012, 149 13th Street, Charlestown, MA 02129, USA
Pediatr Clin North Am 54:563-83, vii. 2007..Finding upstream mechanisms that impact language and non-language abnormalities in autism and specific language impairment would impact the orientation taken by translational attempts to use science to design treatments...
- Autism and environmental genomicsM R Herbert
Pediatric Neurology, Massachusetts General Hospital, Harvard Medical School, USA
Neurotoxicology 27:671-84. 2006..Environmental responsiveness and systems impacts consistent with system-wide findings in autism are thus supported as important considerations in identifying the numerous and complex modes of gene-environment interaction in autism...
- Volumetric neuroimaging and low-dose early-life exposures: loose coupling of pathogenesis-brain-behavior linksMartha R Herbert
Pediatric Neurology, Center for Morphometric Analysis, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Room 6012, Charlestown, MA 02129, USA
Neurotoxicology 26:565-72. 2005..The goal of this paper is to highlight methodological issues involved in designing and interpreting volumetric neuroimaging studies in the light of this loose coupling...
- Brain asymmetries in autism and developmental language disorder: a nested whole-brain analysisM R Herbert
Pediatric Neurology Center for Morphometric Analysis, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Room 6012, Charlestown, MA 02129 USA
Brain 128:213-26. 2005....
- Contributions of the environment and environmentally vulnerable physiology to autism spectrum disordersMartha R Herbert
TRANSCEND Research Program, Pediatric Neurology, Massachusetts General Hospital, Charlestown, Massachusetts, USA
Curr Opin Neurol 23:103-10. 2010..This review presents a rationale and evidence for contributions of environmental influences and environmentally vulnerable physiology to autism spectrum disorders (ASDs)...
- Neuroimaging in disorders of social and emotional functioning: what is the question?Martha R Herbert
Center for Morphometric Analysis, Division of Pediatric Neurology, Department of Neurology, Massachusetts General Hospital East, Neurosciences Center, Harvard Medical School, Charlestown, MA 02129, USA
J Child Neurol 19:772-84. 2004....
- Localization of white matter volume increase in autism and developmental language disorderMartha R Herbert
Center for Morphometric Analysis, Massachusetts General Hospital, Harvard Medical School, Cambridge, MA, USA
Ann Neurol 55:530-40. 2004....
- Dissociations of cerebral cortex, subcortical and cerebral white matter volumes in autistic boysM R Herbert
Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Brain 126:1182-92. 2003..The cause of this apparent dissociation of cerebral cortical regions from subcortical regions and of cortical white from grey matter is unknown, and merits further investigation...
- Language-association cortex asymmetry in autism and specific language impairmentLies De Fossé
Center for Morphometric Analysis, Massachusetts General Hospital
Ann Neurol 56:757-66. 2004..Linguistically unimpaired boys with autism had similar asymmetry compared with the control group, suggesting that Broca's area asymmetry reversal is related more to language impairment than specifically to autism diagnosis...
- Cortical gray matter differences identified by structural magnetic resonance imaging in pediatric bipolar disorderJean A Frazier
Department of Psychiatry, Harvard Medical School, Boston, MA, USA
Bipolar Disord 7:555-69. 2005..Cortical gray matter (GM) volume deficits have been reported in some studies of adults with BPD; this study assessed the presence of such deficits in children with BPD...
- Structural brain magnetic resonance imaging of limbic and thalamic volumes in pediatric bipolar disorderJean A Frazier
Child and Adolescent Neuropsychiatric Research Program, Cambridge Health Alliance Mystic Center, 1493 Cambridge Street, Cambridge, MA 02139, USA
Am J Psychiatry 162:1256-65. 2005..On the basis of adult studies, the authors hypothesized a priori that youths with bipolar disorder would have amygdalar, hippocampal, and thalamic volume abnormalities...
- Anatomic brain magnetic resonance imaging of the basal ganglia in pediatric bipolar disorderMary S Ahn
Cambridge Health Alliance Department of Psychiatry 1493 Cambridge St Cambridge, MA 02139, USA
J Affect Disord 104:147-54. 2007..The BG (caudate, putamen, globus pallidus, nucleus accumbens) is interconnected with limbic and prefrontal cortical structures and therefore may be implicated in BPD...
- Adjustment for whole brain and cranial size in volumetric brain studies: a review of common adjustment factors and statistical methodsLiam M O'Brien
Harv Rev Psychiatry 14:141-51. 2006..These issues come into play in logically framing the assessment of putative abnormalities in regional brain volumes...
- AUTISM--BRAIN MORPHOMETRY AND COGNITIVE NEUROSCIENCEMartha Herbert; Fiscal Year: 2003..The nature of developmental dysregulation and neural systems abnormalities in this disorder should thus become clearer. ..
- Multimodal Neuroimaging of White Matter in AutismMartha Herbert; Fiscal Year: 2009..Our study design will also detect alternate outcomes and will yield data relevant for multiple levels of translational research. ..