Martha Herbert

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi request reprint Large brains in autism: the challenge of pervasive abnormality
    Martha R Herbert
    Pediatric Neurology, Center for Morphometric Analysis, Massachusetts General Hospital, Charleston, MA 02129, USA
    Neuroscientist 11:417-40. 2005
  2. pmc Offering to share: how to put heads together in autism neuroimaging
    Matthew K Belmonte
    Department of Human Development, Cornell University, Martha Van Rensselaer Hall, Ithaca, NY 14853 4401, USA
    J Autism Dev Disord 38:2-13. 2008
  3. ncbi request reprint Abnormal asymmetry in language association cortex in autism
    Martha R Herbert
    Center for Morphometric Analysis, Massachusetts General Hospital, CNY 149, Room 6012, Boston, MA 02114, USA
    Ann Neurol 52:588-96. 2002
  4. ncbi request reprint Brain abnormalities in language disorders and in autism
    Martha R Herbert
    Department of Neurology, Massachusetts General Hospital, MGH Martinos, CNY 149 6012, 149 13th Street, Charlestown, MA 02129, USA
    Pediatr Clin North Am 54:563-83, vii. 2007
  5. ncbi request reprint Autism and environmental genomics
    M R Herbert
    Pediatric Neurology, Massachusetts General Hospital, Harvard Medical School, USA
    Neurotoxicology 27:671-84. 2006
  6. ncbi request reprint Volumetric neuroimaging and low-dose early-life exposures: loose coupling of pathogenesis-brain-behavior links
    Martha R Herbert
    Pediatric Neurology, Center for Morphometric Analysis, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Room 6012, Charlestown, MA 02129, USA
    Neurotoxicology 26:565-72. 2005
  7. ncbi request reprint Brain asymmetries in autism and developmental language disorder: a nested whole-brain analysis
    M R Herbert
    Pediatric Neurology Center for Morphometric Analysis, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Room 6012, Charlestown, MA 02129 USA
    Brain 128:213-26. 2005
  8. doi request reprint Contributions of the environment and environmentally vulnerable physiology to autism spectrum disorders
    Martha R Herbert
    TRANSCEND Research Program, Pediatric Neurology, Massachusetts General Hospital, Charlestown, Massachusetts, USA
    Curr Opin Neurol 23:103-10. 2010
  9. ncbi request reprint Neuroimaging in disorders of social and emotional functioning: what is the question?
    Martha R Herbert
    Center for Morphometric Analysis, Division of Pediatric Neurology, Department of Neurology, Massachusetts General Hospital East, Neurosciences Center, Harvard Medical School, Charlestown, MA 02129, USA
    J Child Neurol 19:772-84. 2004
  10. ncbi request reprint Localization of white matter volume increase in autism and developmental language disorder
    Martha R Herbert
    Center for Morphometric Analysis, Massachusetts General Hospital, Harvard Medical School, Cambridge, MA, USA
    Ann Neurol 55:530-40. 2004

Research Grants

Detail Information

Publications16

  1. ncbi request reprint Large brains in autism: the challenge of pervasive abnormality
    Martha R Herbert
    Pediatric Neurology, Center for Morphometric Analysis, Massachusetts General Hospital, Charleston, MA 02129, USA
    Neuroscientist 11:417-40. 2005
    ..This convergence of findings and models suggests that a systems- and chronic disease-based reformulation of function and pathophysiology in autism needs to be considered, and it opens the possibility for new treatment targets...
  2. pmc Offering to share: how to put heads together in autism neuroimaging
    Matthew K Belmonte
    Department of Human Development, Cornell University, Martha Van Rensselaer Hall, Ithaca, NY 14853 4401, USA
    J Autism Dev Disord 38:2-13. 2008
    ..A theme in these requirements is the need to preserve creative approaches and risk-taking within individual laboratories at the same time as common standards are provided for these laboratories to build on...
  3. ncbi request reprint Abnormal asymmetry in language association cortex in autism
    Martha R Herbert
    Center for Morphometric Analysis, Massachusetts General Hospital, CNY 149, Room 6012, Boston, MA 02114, USA
    Ann Neurol 52:588-96. 2002
    ..In boys with autism, language and social/face processing-related regions displayed abnormal asymmetry. These structural abnormalities may relate to language and social disturbances observed in autism...
  4. ncbi request reprint Brain abnormalities in language disorders and in autism
    Martha R Herbert
    Department of Neurology, Massachusetts General Hospital, MGH Martinos, CNY 149 6012, 149 13th Street, Charlestown, MA 02129, USA
    Pediatr Clin North Am 54:563-83, vii. 2007
    ..Finding upstream mechanisms that impact language and non-language abnormalities in autism and specific language impairment would impact the orientation taken by translational attempts to use science to design treatments...
  5. ncbi request reprint Autism and environmental genomics
    M R Herbert
    Pediatric Neurology, Massachusetts General Hospital, Harvard Medical School, USA
    Neurotoxicology 27:671-84. 2006
    ..Environmental responsiveness and systems impacts consistent with system-wide findings in autism are thus supported as important considerations in identifying the numerous and complex modes of gene-environment interaction in autism...
  6. ncbi request reprint Volumetric neuroimaging and low-dose early-life exposures: loose coupling of pathogenesis-brain-behavior links
    Martha R Herbert
    Pediatric Neurology, Center for Morphometric Analysis, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Room 6012, Charlestown, MA 02129, USA
    Neurotoxicology 26:565-72. 2005
    ..The goal of this paper is to highlight methodological issues involved in designing and interpreting volumetric neuroimaging studies in the light of this loose coupling...
  7. ncbi request reprint Brain asymmetries in autism and developmental language disorder: a nested whole-brain analysis
    M R Herbert
    Pediatric Neurology Center for Morphometric Analysis, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Room 6012, Charlestown, MA 02129 USA
    Brain 128:213-26. 2005
    ....
  8. doi request reprint Contributions of the environment and environmentally vulnerable physiology to autism spectrum disorders
    Martha R Herbert
    TRANSCEND Research Program, Pediatric Neurology, Massachusetts General Hospital, Charlestown, Massachusetts, USA
    Curr Opin Neurol 23:103-10. 2010
    ..This review presents a rationale and evidence for contributions of environmental influences and environmentally vulnerable physiology to autism spectrum disorders (ASDs)...
  9. ncbi request reprint Neuroimaging in disorders of social and emotional functioning: what is the question?
    Martha R Herbert
    Center for Morphometric Analysis, Division of Pediatric Neurology, Department of Neurology, Massachusetts General Hospital East, Neurosciences Center, Harvard Medical School, Charlestown, MA 02129, USA
    J Child Neurol 19:772-84. 2004
    ....
  10. ncbi request reprint Localization of white matter volume increase in autism and developmental language disorder
    Martha R Herbert
    Center for Morphometric Analysis, Massachusetts General Hospital, Harvard Medical School, Cambridge, MA, USA
    Ann Neurol 55:530-40. 2004
    ....
  11. ncbi request reprint Dissociations of cerebral cortex, subcortical and cerebral white matter volumes in autistic boys
    M R Herbert
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Brain 126:1182-92. 2003
    ..The cause of this apparent dissociation of cerebral cortical regions from subcortical regions and of cortical white from grey matter is unknown, and merits further investigation...
  12. ncbi request reprint Language-association cortex asymmetry in autism and specific language impairment
    Lies De Fossé
    Center for Morphometric Analysis, Massachusetts General Hospital
    Ann Neurol 56:757-66. 2004
    ..Linguistically unimpaired boys with autism had similar asymmetry compared with the control group, suggesting that Broca's area asymmetry reversal is related more to language impairment than specifically to autism diagnosis...
  13. pmc Cortical gray matter differences identified by structural magnetic resonance imaging in pediatric bipolar disorder
    Jean A Frazier
    Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    Bipolar Disord 7:555-69. 2005
    ..Cortical gray matter (GM) volume deficits have been reported in some studies of adults with BPD; this study assessed the presence of such deficits in children with BPD...
  14. ncbi request reprint Structural brain magnetic resonance imaging of limbic and thalamic volumes in pediatric bipolar disorder
    Jean A Frazier
    Child and Adolescent Neuropsychiatric Research Program, Cambridge Health Alliance Mystic Center, 1493 Cambridge Street, Cambridge, MA 02139, USA
    Am J Psychiatry 162:1256-65. 2005
    ..On the basis of adult studies, the authors hypothesized a priori that youths with bipolar disorder would have amygdalar, hippocampal, and thalamic volume abnormalities...
  15. ncbi request reprint Anatomic brain magnetic resonance imaging of the basal ganglia in pediatric bipolar disorder
    Mary S Ahn
    Cambridge Health Alliance Department of Psychiatry 1493 Cambridge St Cambridge, MA 02139, USA
    J Affect Disord 104:147-54. 2007
    ..The BG (caudate, putamen, globus pallidus, nucleus accumbens) is interconnected with limbic and prefrontal cortical structures and therefore may be implicated in BPD...
  16. ncbi request reprint Adjustment for whole brain and cranial size in volumetric brain studies: a review of common adjustment factors and statistical methods
    Liam M O'Brien
    Colby College
    Harv Rev Psychiatry 14:141-51. 2006
    ..These issues come into play in logically framing the assessment of putative abnormalities in regional brain volumes...

Research Grants5

  1. AUTISM--BRAIN MORPHOMETRY AND COGNITIVE NEUROSCIENCE
    Martha Herbert; Fiscal Year: 2003
    ..The nature of developmental dysregulation and neural systems abnormalities in this disorder should thus become clearer. ..
  2. Multimodal Neuroimaging of White Matter in Autism
    Martha Herbert; Fiscal Year: 2007
    ..Our study design will also detect alternate outcomes and will yield data relevant for multiple levels of translational research. ..
  3. Multimodal Neuroimaging of White Matter in Autism
    Martha Herbert; Fiscal Year: 2009
    ..Our study design will also detect alternate outcomes and will yield data relevant for multiple levels of translational research. ..