Research Topics
| Aude HeninSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
Research Grants
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Detail Information
Publications
Psychopathology in the offspring of parents with bipolar disorder: a controlled studyAude Henin
Pediatric Psychopharmacology Unit and Harvard Bipolar Research Program, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02138, USA
Biol Psychiatry 58:554-61. 2005..To examine the risk for psychopathology in offspring at risk for bipolar disorder and the course of psychiatric disorders in these youth...- Can bipolar disorder-specific neuropsychological impairments in children be identified?Aude Henin
Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Cambridge, MA 02138, USA
J Consult Clin Psychol 75:210-20. 2007..Thus, comorbidity with ADHD may account for many of the neuropsychological deficits observed in children with bipolar disorder... - Childhood antecedent disorders to bipolar disorder in adults: a controlled studyAude Henin
Pediatric Psychopharmacology Unit and Bipolar Clinic and Research Program, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02138, United States
J Affect Disord 99:51-7. 2007..The aim of the study was to examine antecedent childhood psychiatric disorders in adult patients with bipolar disorder... 
Is psychopharmacologic treatment associated with neuropsychological deficits in bipolar youth?Aude Henin
Pediatric Psychopharmacology Unit, Massachusetts General Hospital, 185 Alewife Brook Pkwy, Suite 2000, Cambridge, MA 02138, USA
J Clin Psychiatry 70:1178-85. 2009..To evaluate the impact of psychopharmacologic treatments on neuropsychological functioning in bipolar youth...
Disruptive behavior disorders in offspring of parents with major depression: associations with parental behavior disordersDina R Hirshfeld-Becker
Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, United States
J Affect Disord 111:176-84. 2008....- Developmental trajectories of anxiety disorders in offspring at high risk for panic disorder and major depressionJoseph Biederman
Massachusetts General Hospital, Pediatric Psychopharmacology Unit, Boston, MA 02114, USA
Psychiatry Res 153:245-52. 2007.... - Psychopathology in adolescent offspring of parents with panic disorder, major depression, or both: a 10-year follow-upDina R Hirshfeld-Becker
Department of Psychiatry, Massachusetts General Hospital, USA
Am J Psychiatry 169:1175-84. 2012..The authors examined the specificity and course of psychiatric disorders from early childhood through adolescence in offspring of parents with confirmed panic disorder and major depressive disorder... - Effects of parental anxiety disorders in children at high risk for panic disorder: a controlled studyJoseph Biederman
Massachusetts General Hospital, Pediatric Psychopharmacology Research, Boston, MA 02114, United States
J Affect Disord 94:191-7. 2006..To examine the association between anxiety disorders in parents and offspring in a sample of children at risk for panic disorder. We hypothesized that individual anxiety disorders will breed true in offspring... - The child behavior checklist broad-band scales predict subsequent psychopathology: A 5-year follow-upCarter R Petty
Massachusetts General Hospital, Pediatric Psychopharmacology Unit, Warren 705, 15 Parkman Street, Boston, MA 02114, USA
J Anxiety Disord 22:532-9. 2008..To evaluate the utility of the Child Behavior Check list (CBCL) for identifying children of parents with panic disorder or major depression at high-risk for future psychopathology... - Child behavior checklist clinical scales discriminate referred youth with autism spectrum disorder: a preliminary studyJoseph Biederman
Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Boston, MA 02114, USA
J Dev Behav Pediatr 31:485-90. 2010.... - Psychopathology in the young offspring of parents with bipolar disorder: a controlled pilot studyDina R Hirshfeld-Becker
Pediatric Psychopharmacology Program, Massachusetts General Hospital, 185 Alewife Brook Parkway, Suite 2100, Cambridge, MA 02138, USA
Psychiatry Res 145:155-67. 2006..Results support the hypotheses of elevated behavior, anxiety, and mood disorders among offspring at risk for bipolar disorder, and suggest that this psychopathology is already evident in early childhood... - Cognitive development in adults with attention-deficit/hyperactivity disorder: a controlled study in medication-naive adults across the adult life cycleJoseph Biederman
Massachusetts General Hospital, Pediatric Psychopharmacology Unit, 55 Fruit St, YAW 6A 6900, Boston, MA 02114, USA
J Clin Psychiatry 72:11-6. 2011.... - Antecedents to panic disorder in nonreferred adultsJoseph Biederman
Pediatric Psychopharmacology Clinic, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
J Clin Psychiatry 67:1179-86. 2006..The current study examined both childhood and adult comorbid disorders as potential antecedent disorders to panic disorder in a large sample of nonreferred adults... - Executive functioning in offspring at risk for depression and anxietyJamie A Micco
Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, 85 Alewife Brook Parkway, Suite 2000, Cambridge, MA 02138, USA
Depress Anxiety 26:780-90. 2009..Studies of at-risk offspring can shed light on this question by examining whether EFDs characterize children at high risk for depression and anxiety who are not yet symptomatic... - A controlled longitudinal 5-year follow-up study of children at high and low risk for panic disorder and major depressionJoseph Biederman
Pediatric Psychopharmacology Program, Massachusetts General Hospital, Department of Psychiatry, Harvard Medical School, Boston, MA 02114, USA
Psychol Med 36:1141-52. 2006..To evaluate the longitudinal course of psychiatric disorders in children of parents with panic disorder (PD) and major depression (MD) as they transition through the period of risk from childhood into adolescence... - Clinical outcomes of laboratory-observed preschool behavioral disinhibition at five-year follow-upDina R Hirshfeld-Becker
Pediatric Psychopharmacology Program, Massachusetts General Hospital, 185 Alewife Brook Parkway, Cambridge, MA 02138, USA
Biol Psychiatry 62:565-72. 2007..In the present study, our objective was to examine the diagnostic outcome in middle childhood of behavioral disinhibition assessed at preschool age among offspring at risk for anxiety and mood disorders... - Behavioral inhibition in preschool children at risk is a specific predictor of middle childhood social anxiety: a five-year follow-upDina R Hirshfeld-Becker
Harvard Medical School Massachusetts General Hospital, Boston, MA 02138, USA
J Dev Behav Pediatr 28:225-33. 2007..It has been hypothesized to be a risk factor for anxiety disorders. In this prospective longitudinal study, we compared the psychiatric outcomes in middle childhood of children evaluated at preschool age for BI... - Parental predictors of pediatric panic disorder/agoraphobia: a controlled study in high-risk offspringJoseph Biederman
Pediatric Psychopharmacology Clinic, Massachusetts General Hospital, Boston, 02114, USA
Depress Anxiety 22:114-20. 2005..These findings suggest that psychiatric comorbidity with other anxiety disorders and with bipolar disorder in parents with PD and their spouses confer a particularly high risk in their offspring to develop PD/AG in childhood... - Examining the association between stimulant treatment and cognitive outcomes across the life cycle of adults with attention-deficit/hyperactivity disorder: a controlled cross-sectional studyJoseph Biederman
Clinical and Research Programs in Pediatric Psychiatry and Adult ADHD at Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
J Nerv Ment Dis 200:69-75. 2012..However, this does not indicate a clear causal relationship... - Patterns of comorbidity in panic disorder and major depression: findings from a nonreferred sampleJoseph Biederman
Pediatric Psychopharmacology Unit of the Child Psychiatry Service, Massachusetts General Hospital, Boston 02114, USA
Depress Anxiety 21:55-60. 2005.... - Childhood antecedents to panic disorder in referred and nonreferred adultsJoseph Biederman
Pediatric Psychopharmacology Clinic, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
J Child Adolesc Psychopharmacol 15:549-61. 2005..We used a recursive partitioning method to examine antecedent childhood anxiety disorders in large samples of referred and nonreferred subjects with and without panic disorder... - Does referral bias impact findings in high-risk offspring for anxiety disorders? A controlled study of high-risk children of non-referred parents with panic disorder/agoraphobia and major depressionJoseph Biederman
Pediatric Psychopharmacology Program and the Department of Psychiatry, Massachusetts General Hospital, Warren 705, 15 Parkman St, Boston, MA 02114, USA
J Affect Disord 82:209-16. 2004..This study evaluated whether these patterns of transmission between parents and high-risk offspring are moderated by referral bias... - Examination of concordance between maternal and youth reports in the diagnosis of pediatric bipolar disorderJoseph Biederman
Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, 55 Fruit Street, Warren 705, Boston, MA 02114, USA
Bipolar Disord 11:298-306. 2009..To this end we compared discordant (mother positive and youth negative) and concordant (mother and youth positive) cases... - Cognitive behavioral therapy for 4- to 7-year-old children with anxiety disorders: a randomized clinical trialDina R Hirshfeld-Becker
Massachusetts General Hospital, 185 Alewife Brook Parkway, Cambridge, MA 02138, USA
J Consult Clin Psychol 78:498-510. 2010..To examine the efficacy of a developmentally appropriate parent-child cognitive behavioral therapy (CBT) protocol for anxiety disorders in children ages 4-7 years... - Impact of executive function deficits in youth with bipolar I disorder: a controlled studyJoseph Biederman
Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Boston, MA, USA
Psychiatry Res 186:58-64. 2011..Youth with BP-I disorder and EFDs are at high risk for significant impairments in academic functioning... - Association of bipolar and substance use disorders in parents of adolescents with bipolar disorderTimothy E Wilens
Pediatric Psychopharmacology Unit, Massachusetts General Hospital, and Department of Psychiatry, Harvard Medical School, Boston, Massachusetts 02114, USA
Biol Psychiatry 62:129-34. 2007..We have previously shown that juvenile bipolar disorder (BPD) is a risk for substance use disorders (SUD). Here we examine the expression of both disorders in families of youth with BPD to evaluate the familial risk mechanism... - Posttraumatic stress disorder symptoms following media exposure to tragic events: impact of 9/11 on children at risk for anxiety disordersMichael W Otto
Massachusetts General Hospital and Harvard Medical School, MA, United States
J Anxiety Disord 21:888-902. 2007..Given the links between PTSD symptoms and viewing habits, parental monitoring of media exposure may be important for younger children... - Further evidence of an association between adolescent bipolar disorder with smoking and substance use disorders: a controlled studyTimothy E Wilens
Massachusetts General Hospital, Pediatric Psychopharmacology Unit, Boston, MA 02114, USA
Drug Alcohol Depend 95:188-98. 2008..Clinicians should carefully screen adolescents with bipolar disorder for substance and cigarette use... - Discriminant and concurrent validity of a simplified DSM-based structured diagnostic instrument for the assessment of autism spectrum disorders in youth and young adultsGagan Joshi
Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Boston, MA, USA
BMC Psychiatry 11:204. 2011..To evaluate the concurrent and discriminant validity of a brief DSM-based structured diagnostic interview for referred individuals with autism spectrum disorders (ASDs)... - Laboratory-observed behavioral disinhibition in the young offspring of parents with bipolar disorder: a high-risk pilot studyDina R Hirshfeld-Becker
Mass General Hospital Pediatric Psychopharmacology Program, 185 Alewife Brook Parkway, Suite 2100, Cambridge, MA 02138, USA
Am J Psychiatry 163:265-71. 2006..This study tested whether behavioral disinhibition is more prevalent among offspring of parents with bipolar disorder than among offspring of parents without bipolar disorder... - Anxiety and depressive disorders in offspring at high risk for anxiety: a meta-analysisJamie A Micco
Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital Harvard Medical School, Suite 2000, Cambridge, MA 02138, USA
J Anxiety Disord 23:1158-64. 2009..Results suggest that parental anxiety disorders confer significant risk for anxiety and depression in offspring. Additional studies are needed to examine whether there are differences among specific parental anxiety disorders... - The heavy burden of psychiatric comorbidity in youth with autism spectrum disorders: a large comparative study of a psychiatrically referred populationGagan Joshi
Pediatric Psychopharmacology Research Department, Massachusetts General Hospital, Boston, MA, USA
J Autism Dev Disord 40:1361-70. 2010..These findings emphasize the heavy burden of psychiatric comorbidity afflicting youth with ASD and may be important targets for intervention... - Brain biochemical effects of methylphenidate treatment using proton magnetic spectroscopy in youth with attention-deficit hyperactivity disorder: a controlled pilot studyPaul Hammerness
Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Boston, 02138, USA
CNS Neurosci Ther 18:34-40. 2012.... - Cognitive-behavioral intervention with young anxious childrenDina R Hirshfeld-Becker
Harvard Medical School and Massachusetts General Hospital, Boston, MA, USA
Harv Rev Psychiatry 16:113-25. 2008.... - High risk studies and developmental antecedents of anxiety disordersDina R Hirshfeld-Becker
MGH Clinical and Research Program in Pediatric Psychopharmacology, 185 Alewife Brook Parkway, Suite 2000, Cambridge, MA 02138, USA
Am J Med Genet C Semin Med Genet 148:99-117. 2008.... - Risk of substance use disorders in adolescents with bipolar disorderTimothy E Wilens
Pediatric Psychopharmacology Unit, Child Psychiatric Service, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA
J Am Acad Child Adolesc Psychiatry 43:1380-6. 2004..Considering the public health importance of this issue, the authors now report on a controlled study of adolescents with and without BPD to evaluate the risk of SUD... - Applying cognitive-behavioral therapy for anxiety to the younger childDina R Hirshfeld-Becker
Child Cognitive Behavioral Therapy Program, Department of Psychiatry, Massachusetts General Hospital MGH, 55 Fruit Street, Boston, MA 02114, USA
Child Adolesc Psychiatr Clin N Am 20:349-68. 2011..The authors conclude with recommendations for future directions for research in this area... - Moderating effects of major depression on patterns of comorbidity in patients with panic disorderJoseph Biederman
Clinical Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, and Harvard Medical School, WACC 725, 15 Parkman Street, Boston, MA 02114, USA
Psychiatry Res 126:143-9. 2004..Overanxious disorder was associated with both panic disorder and major depression. Major depression has important moderating effects on patterns of comorbidity of panic disorder in referred adults... - Effectiveness of collaborative problem solving in affectively dysregulated children with oppositional-defiant disorder: initial findingsRoss W Greene
Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA
J Consult Clin Psychol 72:1157-64. 2004..These improvements were in all instances equivalent, and in many instances superior, to the improvements produced by PT. Implications of these findings for further research on and treatment selection in children with ODD are discussed... - Behavioral inhibitionDina R Hirshfeld-Becker
Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA
Depress Anxiety 25:357-67. 2008.... - Assessing anxiety with the Child Behavior Checklist and the Teacher Report FormPhilip C Kendall
Temple University, Department of Psychology, Philadelphia, PA 19122, United States
J Anxiety Disord 21:1004-15. 2007..Journal of Clinical Child and Adolescent Psychology, 32, 328-340] CBCL Anxiety subscale, the CBCL-A predicted comparably. Findings are discussed in terms of the CBCL-A and TRF-A as clinical tools...
Research Grants
- Reducing High-Risk Behaviors Among Bipolar Patients Transitioning to AdulthoodAude Henin; Fiscal Year: 2007..Thus, in offering ways to augment pharmacotherapy in mitigating the severity and impact of this devastating disorder in youth, the proposed study will be of major clinical, public health, and scientific importance. ..