Research Topics
| J HellmanSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
Research Grants
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Detail Information
Publications
Outer membrane protein A (OmpA), peptidoglycan-associated lipoprotein (PAL), and murein lipoprotein (MLP) are released in experimental Gram-negative sepsisJ Hellman
Department of Anesthesia and Critical Care, Massachusetts General Hospital, Charlestown, MA, USA
J Endotoxin Res 7:69-72. 2001..The results indicate that OmpA, PAL, and MLP are released and circulate in experimental Gram-negative sepsis and suggest that a proportion of released OMPs are tightly associated with LPS...- Bacterial peptidoglycan-associated lipoprotein is released into the bloodstream in gram-negative sepsis and causes inflammation and death in miceJudith Hellman
Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
J Biol Chem 277:14274-80. 2002..The studies suggest that PAL may be an important bacterial mediator of Gram-negative sepsis... - Murein lipoprotein, peptidoglycan-associated lipoprotein, and outer membrane protein A are present in purified rough and smooth lipopolysaccharidesJudith Hellman
Department of Anesthesia and Critical Care, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA
J Infect Dis 188:286-9. 2003..The studies indicate that PAL and MLP are common contaminants of purified LPS and raise the possibility that these contaminants may influence results of studies performed using purified LPS... - Release of gram-negative outer-membrane proteins into human serum and septic rat blood and their interactions with immunoglobulin in antiserum to Escherichia coli J5J Hellman
Infectious Disease Unit, Massachusetts General Hospital CNY, Charlestown, MA, USA
J Infect Dis 181:1034-43. 2000..Anti-J5 IgG selectively captured an 18-kDa OMP released into serum and into plasma from septic rats. The results raise the possibility that anti-J5 IgG may, in part, protect via anti-OMP antibodies... 
Outer membrane protein A, peptidoglycan-associated lipoprotein, and murein lipoprotein are released by Escherichia coli bacteria into serumJ Hellman
Department of Infectious Diseases, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
Infect Immun 68:2566-72. 2000..The studies identify the OMPs released into human serum and into the circulation in an experimental model of sepsis as OmpA, PAL, and MLP...- MyD88-dependent immune activation mediated by human immunodeficiency virus type 1-encoded Toll-like receptor ligandsAngela Meier
Partners AIDS Research Center, Massachusetts General Hospital, 149 13th Street, Boston, MA 02129, USA
J Virol 81:8180-91. 2007..These data provide an initial rationale for inhibiting the TLR pathway to directly reduce the chronic immune activation induced by HIV-1 and the associated immune pathogenesis... - Toll-like receptor 2 activation by bacterial peptidoglycan-associated lipoprotein activates cardiomyocyte inflammation and contractile dysfunctionXinsheng Zhu
Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Crit Care Med 35:886-92. 2007..The present studies assessed the effects of PAL on cardiomyocyte function and its signal transduction in cardiomyocytes... - Passive immunization to outer membrane proteins MLP and PAL does not protect mice from sepsisCatherine H Valentine
Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
Mol Med 12:252-8. 2006..These studies suggest that a different mechanism of protection is involved... - Bacterial peptidoglycan-associated lipoprotein: a naturally occurring toll-like receptor 2 agonist that is shed into serum and has synergy with lipopolysaccharideMichael D Liang
Department of Pathology, Boston University Medical Center, Boston, Massachusetts, USA
J Infect Dis 191:939-48. 2005..These data suggest that PAL may play an important role in the pathogenesis of sepsis and imply that physiologically relevant PAL and LPS are shed into serum and act in concert to initiate inflammation in sepsis... - Protective efficacy of CAP18106-138-immunoglobulin G in sepsisH Shaw Warren
Department of Pediatrics and Medicine, Massachusetts General Hospital, Boston, Massachusetts 02129, USA
J Infect Dis 188:1382-93. 2003..06), suggesting that direct detoxification of LPS was not the only mechanism of protection. Chemical or genetic coupling of antimicrobial peptides to IgG may be a means of using these peptides to treat infections... - Activation of Toll-like receptor 2 impairs hypoxic pulmonary vasoconstriction in miceBodil Petersen
Department of Anesthesia and Critical Care, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
Am J Physiol Lung Cell Mol Physiol 294:L300-8. 2008..These data indicate that TLR2 activation impairs HPV and induces deleterious systemic effects in mice and suggest that TLR2 pathways may be important in sepsis-induced respiratory failure... - MyD88-dependent and MyD88-independent pathways in synergy, priming, and tolerance between TLR agonistsAranya Bagchi
Department of Anesthesia and Critical Care, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
J Immunol 178:1164-71. 2007..Thus, under the conditions studied here, simultaneous and sequential activation of both the D and I pathways causes synergy and priming, respectively, and tolerance is induced by agonists that act through the same pathway... - Increased leakage of sarcoplasmic reticulum Ca2+ contributes to abnormal myocyte Ca2+ handling and shortening in sepsisXinsheng Zhu
Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Crit Care Med 33:598-604. 2005..In the future, modalities that prevent this Ca leakage may prove beneficial in the treatment of sepsis-induced myocyte shortening...
Research Grants
- BACTERIAL SURFACE PROTEINS: POTENTIAL TARGETS FOR SEPSISJudith Hellman; Fiscal Year: 2004..The ultimate goal of the candidate is to apply the fundamental knowledge of mechanisms involved in sepsis to develop anti-sepsis strategies that target bacterial toxins. ..