J Hellman

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi request reprint Murein lipoprotein, peptidoglycan-associated lipoprotein, and outer membrane protein A are present in purified rough and smooth lipopolysaccharides
    Judith Hellman
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA
    J Infect Dis 188:286-9. 2003
  2. ncbi request reprint Outer membrane protein A (OmpA), peptidoglycan-associated lipoprotein (PAL), and murein lipoprotein (MLP) are released in experimental Gram-negative sepsis
    J Hellman
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Charlestown, MA, USA
    J Endotoxin Res 7:69-72. 2001
  3. ncbi request reprint Bacterial peptidoglycan-associated lipoprotein is released into the bloodstream in gram-negative sepsis and causes inflammation and death in mice
    Judith Hellman
    Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Biol Chem 277:14274-80. 2002
  4. ncbi request reprint Release of gram-negative outer-membrane proteins into human serum and septic rat blood and their interactions with immunoglobulin in antiserum to Escherichia coli J5
    J Hellman
    Infectious Disease Unit, Massachusetts General Hospital CNY, Charlestown, MA, USA
    J Infect Dis 181:1034-43. 2000
  5. pmc Outer membrane protein A, peptidoglycan-associated lipoprotein, and murein lipoprotein are released by Escherichia coli bacteria into serum
    J Hellman
    Department of Infectious Diseases, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Infect Immun 68:2566-72. 2000
  6. pmc MyD88-dependent immune activation mediated by human immunodeficiency virus type 1-encoded Toll-like receptor ligands
    Angela Meier
    Partners AIDS Research Center, Massachusetts General Hospital, 149 13th Street, Boston, MA 02129, USA
    J Virol 81:8180-91. 2007
  7. ncbi request reprint Toll-like receptor 2 activation by bacterial peptidoglycan-associated lipoprotein activates cardiomyocyte inflammation and contractile dysfunction
    Xinsheng Zhu
    Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Crit Care Med 35:886-92. 2007
  8. pmc Passive immunization to outer membrane proteins MLP and PAL does not protect mice from sepsis
    Catherine H Valentine
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Mol Med 12:252-8. 2006
  9. ncbi request reprint Bacterial peptidoglycan-associated lipoprotein: a naturally occurring toll-like receptor 2 agonist that is shed into serum and has synergy with lipopolysaccharide
    Michael D Liang
    Department of Pathology, Boston University Medical Center, Boston, Massachusetts, USA
    J Infect Dis 191:939-48. 2005
  10. ncbi request reprint Protective efficacy of CAP18106-138-immunoglobulin G in sepsis
    H Shaw Warren
    Department of Pediatrics and Medicine, Massachusetts General Hospital, Boston, Massachusetts 02129, USA
    J Infect Dis 188:1382-93. 2003

Research Grants

Collaborators

  • H S Warren
  • M P Fink
  • Fumito Ichinose
  • Bin Li
  • Wei Chao
  • Galit Alter
  • Aranya Bagchi
  • Xinsheng Zhu
  • Bodil Petersen
  • Hae Sook Shin
  • Angela Meier
  • Ulrich Schmidt
  • Roger J Hajjar
  • Catherine H Valentine
  • Laura K Beasley-Topliffe
  • Michael D Liang
  • Kenneth D Bloch
  • Misako Shigematsu
  • Warren M Zapol
  • Marcus Altfeld
  • James Trigilio
  • Catherine Valentine
  • Huailong Zhao
  • Elizabeth A Herrup
  • Nicole Frahm
  • Carsten J Kirschning
  • Jan van Lunzen
  • Nickolas Teigen
  • Harlyn Sidhu
  • Hendrik Streeck
  • Hans Juergen Stellbrink
  • Megan M Tehan
  • Jean Claude Lazzaroni
  • Oliver Y Bernecker
  • Naveen S Manohar
  • Matthew J Fenton
  • Hector H Valdivia
  • James A Trigilio
  • Brenda L Tesini

Detail Information

Publications13

  1. ncbi request reprint Murein lipoprotein, peptidoglycan-associated lipoprotein, and outer membrane protein A are present in purified rough and smooth lipopolysaccharides
    Judith Hellman
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA
    J Infect Dis 188:286-9. 2003
    ..The studies indicate that PAL and MLP are common contaminants of purified LPS and raise the possibility that these contaminants may influence results of studies performed using purified LPS...
  2. ncbi request reprint Outer membrane protein A (OmpA), peptidoglycan-associated lipoprotein (PAL), and murein lipoprotein (MLP) are released in experimental Gram-negative sepsis
    J Hellman
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Charlestown, MA, USA
    J Endotoxin Res 7:69-72. 2001
    ..The results indicate that OmpA, PAL, and MLP are released and circulate in experimental Gram-negative sepsis and suggest that a proportion of released OMPs are tightly associated with LPS...
  3. ncbi request reprint Bacterial peptidoglycan-associated lipoprotein is released into the bloodstream in gram-negative sepsis and causes inflammation and death in mice
    Judith Hellman
    Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Biol Chem 277:14274-80. 2002
    ..The studies suggest that PAL may be an important bacterial mediator of Gram-negative sepsis...
  4. ncbi request reprint Release of gram-negative outer-membrane proteins into human serum and septic rat blood and their interactions with immunoglobulin in antiserum to Escherichia coli J5
    J Hellman
    Infectious Disease Unit, Massachusetts General Hospital CNY, Charlestown, MA, USA
    J Infect Dis 181:1034-43. 2000
    ..Anti-J5 IgG selectively captured an 18-kDa OMP released into serum and into plasma from septic rats. The results raise the possibility that anti-J5 IgG may, in part, protect via anti-OMP antibodies...
  5. pmc Outer membrane protein A, peptidoglycan-associated lipoprotein, and murein lipoprotein are released by Escherichia coli bacteria into serum
    J Hellman
    Department of Infectious Diseases, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Infect Immun 68:2566-72. 2000
    ..The studies identify the OMPs released into human serum and into the circulation in an experimental model of sepsis as OmpA, PAL, and MLP...
  6. pmc MyD88-dependent immune activation mediated by human immunodeficiency virus type 1-encoded Toll-like receptor ligands
    Angela Meier
    Partners AIDS Research Center, Massachusetts General Hospital, 149 13th Street, Boston, MA 02129, USA
    J Virol 81:8180-91. 2007
    ..These data provide an initial rationale for inhibiting the TLR pathway to directly reduce the chronic immune activation induced by HIV-1 and the associated immune pathogenesis...
  7. ncbi request reprint Toll-like receptor 2 activation by bacterial peptidoglycan-associated lipoprotein activates cardiomyocyte inflammation and contractile dysfunction
    Xinsheng Zhu
    Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Crit Care Med 35:886-92. 2007
    ..The present studies assessed the effects of PAL on cardiomyocyte function and its signal transduction in cardiomyocytes...
  8. pmc Passive immunization to outer membrane proteins MLP and PAL does not protect mice from sepsis
    Catherine H Valentine
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Mol Med 12:252-8. 2006
    ..These studies suggest that a different mechanism of protection is involved...
  9. ncbi request reprint Bacterial peptidoglycan-associated lipoprotein: a naturally occurring toll-like receptor 2 agonist that is shed into serum and has synergy with lipopolysaccharide
    Michael D Liang
    Department of Pathology, Boston University Medical Center, Boston, Massachusetts, USA
    J Infect Dis 191:939-48. 2005
    ..These data suggest that PAL may play an important role in the pathogenesis of sepsis and imply that physiologically relevant PAL and LPS are shed into serum and act in concert to initiate inflammation in sepsis...
  10. ncbi request reprint Protective efficacy of CAP18106-138-immunoglobulin G in sepsis
    H Shaw Warren
    Department of Pediatrics and Medicine, Massachusetts General Hospital, Boston, Massachusetts 02129, USA
    J Infect Dis 188:1382-93. 2003
    ..06), suggesting that direct detoxification of LPS was not the only mechanism of protection. Chemical or genetic coupling of antimicrobial peptides to IgG may be a means of using these peptides to treat infections...
  11. ncbi request reprint Activation of Toll-like receptor 2 impairs hypoxic pulmonary vasoconstriction in mice
    Bodil Petersen
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Am J Physiol Lung Cell Mol Physiol 294:L300-8. 2008
    ..These data indicate that TLR2 activation impairs HPV and induces deleterious systemic effects in mice and suggest that TLR2 pathways may be important in sepsis-induced respiratory failure...
  12. ncbi request reprint MyD88-dependent and MyD88-independent pathways in synergy, priming, and tolerance between TLR agonists
    Aranya Bagchi
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    J Immunol 178:1164-71. 2007
    ..Thus, under the conditions studied here, simultaneous and sequential activation of both the D and I pathways causes synergy and priming, respectively, and tolerance is induced by agonists that act through the same pathway...
  13. ncbi request reprint Increased leakage of sarcoplasmic reticulum Ca2+ contributes to abnormal myocyte Ca2+ handling and shortening in sepsis
    Xinsheng Zhu
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Crit Care Med 33:598-604. 2005
    ..In this study we tested the hypothesis that alterations in cardiac calcium homeostasis due to sepsis underlie the observed myocyte dysfunction...

Research Grants1

  1. BACTERIAL SURFACE PROTEINS: POTENTIAL TARGETS FOR SEPSIS
    Judith Hellman; Fiscal Year: 2004
    ..The ultimate goal of the candidate is to apply the fundamental knowledge of mechanisms involved in sepsis to develop anti-sepsis strategies that target bacterial toxins. ..