Thomas Heldt

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. pmc Continuous quantitative monitoring of cerebral oxygen metabolism in neonates by ventilator-gated analysis of NIRS recordings
    Thomas Heldt
    Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Acta Neurochir Suppl 114:177-80. 2012
  2. pmc Model-based data integration in clinical environments
    Thomas Heldt
    Computational Physiology and Clinical Inference Group, Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Conf Proc IEEE Eng Med Biol Soc 2010:5209-12. 2010
  3. ncbi request reprint Cycle-averaged dynamics of a periodically driven, closed-loop circulation model
    T Heldt
    Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Control Eng Pract 13:1163-71. 2005
  4. pmc Multiparameter Intelligent Monitoring in Intensive Care II: a public-access intensive care unit database
    Mohammed Saeed
    Massachusetts Institute of Technology, Cambridge, MA, USA
    Crit Care Med 39:952-60. 2011
  5. doi request reprint Model-based noninvasive estimation of intracranial pressure from cerebral blood flow velocity and arterial pressure
    Faisal M Kashif
    Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Sci Transl Med 4:129ra44. 2012
  6. pmc Distilling clinically interpretable information from data collected on next-generation wearable sensors
    Bryan Haslam
    Computational Physiology and Clinical Inference Group, ResearchLaboratory of Electronics, Massachusetts Institute of Technology, CambridgeMA, USA
    Conf Proc IEEE Eng Med Biol Soc 2011:1729-32. 2011
  7. doi request reprint The ear as a location for wearable vital signs monitoring
    David Da He
    Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Conf Proc IEEE Eng Med Biol Soc 2010:6389-92. 2010
  8. doi request reprint A computational model of hemorrhage and dehydration suggests a pathophysiological mechanism: Starling-mediated protein trapping
    Andrew T Reisner
    Division of Health Sciences and Technology, Massachusetts Institute of Technology, Boston, MA, USA
    Am J Physiol Heart Circ Physiol 304:H620-31. 2013
  9. pmc The cardiac output from blood pressure algorithms trial
    James X Sun
    Division of Health Sciences and Technology, Massachusetts Institute of Technology, Massachusetts General Hospital, Boston, MA, USA
    Crit Care Med 37:72-80. 2009
  10. ncbi request reprint Model-based parameter estimation using cardiovascular response to orthostatic stress
    T Heldt
    Massachusetts Institute of Technology, Cambridge, MA, USA
    Comput Cardiol 28:337-40. 2001

Collaborators

Detail Information

Publications13

  1. pmc Continuous quantitative monitoring of cerebral oxygen metabolism in neonates by ventilator-gated analysis of NIRS recordings
    Thomas Heldt
    Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Acta Neurochir Suppl 114:177-80. 2012
    ..The resultant estimates compare very favorably to previously reported data obtained by non-continuous and invasive means from preterm infants in neonatal critical care...
  2. pmc Model-based data integration in clinical environments
    Thomas Heldt
    Computational Physiology and Clinical Inference Group, Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Conf Proc IEEE Eng Med Biol Soc 2010:5209-12. 2010
    ..We outline some of the challenges and opportunities, and propose strategies for model-based integration of physiological data to improve patient monitoring...
  3. ncbi request reprint Cycle-averaged dynamics of a periodically driven, closed-loop circulation model
    T Heldt
    Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Control Eng Pract 13:1163-71. 2005
    ..It is also amenable to systematic order reduction methods that lead to further efficiencies. Despite its simplicity, the averaged model captures the dynamics relevant to the representation of a range of cardiovascular reflex mechanisms...
  4. pmc Multiparameter Intelligent Monitoring in Intensive Care II: a public-access intensive care unit database
    Mohammed Saeed
    Massachusetts Institute of Technology, Cambridge, MA, USA
    Crit Care Med 39:952-60. 2011
    ..This freely available database is intended to support epidemiologic research in critical care medicine and serve as a resource to evaluate new clinical decision support and monitoring algorithms...
  5. doi request reprint Model-based noninvasive estimation of intracranial pressure from cerebral blood flow velocity and arterial pressure
    Faisal M Kashif
    Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Sci Transl Med 4:129ra44. 2012
    ..5 mmHg and SDE to 5.9 mmHg. This accuracy is already comparable to that of some invasive ICP measurement methods in current clinical use...
  6. pmc Distilling clinically interpretable information from data collected on next-generation wearable sensors
    Bryan Haslam
    Computational Physiology and Clinical Inference Group, ResearchLaboratory of Electronics, Massachusetts Institute of Technology, CambridgeMA, USA
    Conf Proc IEEE Eng Med Biol Soc 2011:1729-32. 2011
    ..Data was collected on 10 healthy subjects. The derived quantities vary in a manner that is consistent with known physiology. Further work remains to correlate these values with the cardiac health state...
  7. doi request reprint The ear as a location for wearable vital signs monitoring
    David Da He
    Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Conf Proc IEEE Eng Med Biol Soc 2010:6389-92. 2010
    ..Furthermore, the ear provides a discreet and natural anchoring point that reduces device visibility and the need for adhesives...
  8. doi request reprint A computational model of hemorrhage and dehydration suggests a pathophysiological mechanism: Starling-mediated protein trapping
    Andrew T Reisner
    Division of Health Sciences and Technology, Massachusetts Institute of Technology, Boston, MA, USA
    Am J Physiol Heart Circ Physiol 304:H620-31. 2013
    ..In conclusion, the model appears valid for a range of blood loss patterns and prehydration states. Further investigation into the in vivo relevance of interstitial protein trapping is justified...
  9. pmc The cardiac output from blood pressure algorithms trial
    James X Sun
    Division of Health Sciences and Technology, Massachusetts Institute of Technology, Massachusetts General Hospital, Boston, MA, USA
    Crit Care Med 37:72-80. 2009
    ..We employed this data set to evaluate a set of investigational algorithms, and to establish a public resource for the meaningful comparison of alternative CO-from-ABP algorithms...
  10. ncbi request reprint Model-based parameter estimation using cardiovascular response to orthostatic stress
    T Heldt
    Massachusetts Institute of Technology, Cambridge, MA, USA
    Comput Cardiol 28:337-40. 2001
    ..We apply the estimation algorithm to both simulated and real data and showed that restriction to the 20 most important parameters does not impair our ability to match the data...
  11. ncbi request reprint Integrating data, models, and reasoning in critical care
    Thomas Heldt
    Laboratory for Electromagntic and Electronic Systems, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Conf Proc IEEE Eng Med Biol Soc 1:350-3. 2006
    ..In this paper, we present our recent efforts towards the development of such an advanced patient monitoring system that aims to improve the efficiency, accuracy, and timeliness of clinical decision making in intensive care...
  12. ncbi request reprint Computational model of cardiovascular function during orthostatic stress
    T Heldt
    Massachusetts Institute of Technology, Cambridge, MA, USA
    Comput Cardiol 27:777-80. 2000
    ..Furthermore, we explore the effects of a potential countermeasure...
  13. ncbi request reprint Computational models of cardiovascular function for analysis of post-flight orthostatic intolerance
    T Heldt
    Massachusetts Institute of Technology, Cambridge, MA, USA
    Comput Cardiol 26:213-6. 1999
    ..Simulations are compared to astronaut stand test data pre - and post-flight in an effort to quantitatively evaluate alternative hypotheses...