Research Topics
| Robert P HasserjianSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
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Detail Information
Publications
Acute erythroid leukemia: a reassessment using criteria refined in the 2008 WHO classificationRobert P Hasserjian
Department of Pathology, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA
Blood 115:1985-92. 2010..Our findings suggest that AEL is in the continuum of MDS and AML with erythroid hyperplasia, where karyotype rather than an arbitrary blast cutoff represents the most important prognostic factor...
Reactive versus neoplastic bone marrow: problems and pitfallsRobert P Hasserjian
Department of Pathology, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02115, USA
Arch Pathol Lab Med 132:587-94. 2008....
Bone marrow findings correlate with clinical outcome in systemic AL amyloidosis patientsR P Hasserjian
James Homer Wright Pathology Laboratory, Department of Biostatistics, Massachusetts General Hospital, Boston, MA, USA
Histopathology 50:567-73. 2007..The aim was to determine if bone marrow pathological parameters at diagnosis were related to clinical behaviour in AL amyloidosis patients...- Pathology of thymic tumorsRobert P Hasserjian
James Homer Wright Pathology Laboratories, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
Semin Thorac Cardiovasc Surg 17:2-11. 2005..Thorough histologic sampling and, in some cases, the appropriate use of ancillary studies such as immunohistochemistry, flow cytometry, and molecular studies, are important in proper pathologic evaluation of thymic tumors... - Immunomodulator agent-related lymphoproliferative disordersRobert P Hasserjian
Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
Mod Pathol 22:1532-40. 2009..Further study is warranted to evaluate how these therapies interact with other immunosuppressive agents and the underlying abnormal immune system to enhance the development of lymphomas and atypical lymphoid proliferations... - Pediatric-type nodal follicular lymphoma: an indolent clonal proliferation in children and adults with high proliferation index and no BCL2 rearrangementAbner Louissaint
James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Boston, MA, USA
Blood 120:2395-404. 2012..PFL-like cases also occur in adults and are associated with indolent behavior in this patient population... - Nodular lymphocyte-predominant hodgkin lymphoma with atypical T cells: a morphologic variant mimicking peripheral T-cell lymphomaAliyah R Sohani
James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Boston, 02114, USA
Am J Surg Pathol 35:1666-78. 2011.... - B-cell lymphomas with concurrent IGH-BCL2 and MYC rearrangements are aggressive neoplasms with clinical and pathologic features distinct from Burkitt lymphoma and diffuse large B-cell lymphomaMatija Snuderl
Department of Pathology, James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Boston, MA 02114, USA
Am J Surg Pathol 34:327-40. 2010..The aggressive clinical behavior and combination of genetic abnormalities seen in these cases may warrant categorization as a separate entity in future classifications and call for novel therapeutic approaches... - Case records of the Massachusetts General Hospital. Case 8-2008. A 33-year-old man with fever, abdominal pain, and pancytopenia after renal transplantationJeremy S Abramson
Cancer Center, Massachusetts General Hospital, USA
N Engl J Med 358:1176-87. 2008 - Beyond the lymphocyte predominant cell: CD4+CD8+ T-cells in nodular lymphocyte predominant Hodgkin lymphomaAliyah Rahemtullah
James Homer Wright Pathology Laboratories, Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
Leuk Lymphoma 49:1870-8. 2008..CD4+CD8+ T-cells have also been identified in the benign entity progressive transformation of germinal centres (PTGC), suggesting a possible relationship between NLPHL and PTGC... - Infectious mononucleosis mimicking lymphoma: distinguishing morphological and immunophenotypic featuresAbner Louissaint
The James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Boston, MA 02114, USA
Mod Pathol 25:1149-59. 2012.... - Primary follicular lymphoma of the gastrointestinal tractJoseph Misdraji
The James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Am J Surg Pathol 35:1255-63. 2011..Follicular lymphoma (FL), a common nodal lymphoma, is rare in the gastrointestinal (GI) tract. We report our experience with primary FL of the GI tract... - Case records of the Massachusetts General Hospital. Case 16-2007. A 61-year-old man with a mediastinal massCameron D Wright
Department of Surgery, Massachusetts General Hospital, USA
N Engl J Med 356:2185-93. 2007 - Case records of the Massachusetts General Hospital. Case 33-2007. A 49-year-old HIV-positive man with anemiaEyal C Attar
Hematology-Oncology Unit, Massachusetts General Hospital, USA
N Engl J Med 357:1745-54. 2007 - Multiparameter immunophenotyping by flow cytometry in multiple myeloma: The diagnostic utility of defining ranges of normal antigenic expression in comparison to histologyElisa Cannizzo
Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, USA
Cytometry B Clin Cytom 78:231-8. 2010..These newly calculated normal ranges for each antigen were applied to our data, and compared to histologic and immunohistochemical findings... - Case records of the Massachusetts General Hospital. Case 30-2006. A 41-year-old man with dyspnea, fever, and lymphadenopathyDavid T Scadden
Department of Hematology-Oncology, Massachusetts General Hospital, USA
N Engl J Med 355:1358-68. 2006 - A double-positive CD4+CD8+ T-cell population is commonly found in nodular lymphocyte predominant Hodgkin lymphomaAliyah Rahemtullah
Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Am J Clin Pathol 126:805-14. 2006..This population may be a clue to the diagnosis of NLPHL, particularly in cases with limited tissue... - Erythroid-predominant myelodysplastic syndromes: enumeration of blasts from nonerythroid rather than total marrow cells provides superior risk stratificationSa A Wang
Department of Pathology, UMass Memorial Medical Center, University of Massachusetts, Worcester, MA, USA
Mod Pathol 21:1394-402. 2008..We conclude that in erythroid-predominant myelodysplastic syndrome, blast calculation as a proportion of marrow nonerythroid rather than total nucleated cells can better stratify patients into prognostically relevant groups... - Reassessment of small lymphocytic lymphoma in the era of monoclonal B-cell lymphocytosisSarah E Gibson
Department of Pathology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
Haematologica 96:1144-52. 2011..Minimal criteria of tissue involvement to separate small lymphocytic lymphoma from monoclonal B-cell lymphocytosis have not been defined... - NK-cell lymphomas and leukemias: a spectrum of tumors with variable manifestations and immunophenotypeRobert P Hasserjian
Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Am J Clin Pathol 127:860-8. 2007..Although some of these cases can be grouped into ENNK/T-NT, classification of tumors that have atypical or discordant features will remain controversial, particularly when EBV is absent... - Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 2-2005. A 39-year-old woman with headache, stiff neck, and photophobiaKaren K Ballen
Division of Hematology and Oncology, Department of Medicine, Massachusetts General Hospital, USA
N Engl J Med 352:274-83. 2005 - Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 19-2004. A 12-year-old boy with fatigue and eosinophiliaMary S Huang
Division of Pediatric Oncology, Massachusetts General Hospital, USA
N Engl J Med 350:2604-12. 2004 - Case records of the Massachusetts General Hospital. Case 17-2006--a 34-year-old man with cavitary lung lesionsEphraim P Hochberg
Division of Hematology and Oncology, Department of Medicine, Massachusetts General Hospital, USA
N Engl J Med 354:2485-93. 2006 - Immunophenotypic changes and clinical outcome in B-cell lymphomas treated with rituximabRania M Seliem
Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
Appl Immunohistochem Mol Morphol 14:18-23. 2006..This study also underscores the importance of using a panel of antibodies to evaluate rituximab-treated B-NHL... - Phase II study of dasatinib in relapsed or refractory chronic lymphocytic leukemiaPhilip C Amrein
Massachusetts General Hospital Cancer Center, Medical Oncology and Department of Biostatistics, Dana Farber Cancer Institute, Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Clin Cancer Res 17:2977-86. 2011..Chronic lymphocytic leukemia (CLL) cells treated with dasatinib in vitro undergo apoptosis via inhibition of Lyn kinase. Thus, in this study we tested the activity of dasatinib in patients with relapsed CLL... - Hodgkin's lymphoma of the thyroid: a clinicopathologic study of five cases and review of the literatureSa A Wang
Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Mod Pathol 18:1577-84. 2005..Histologic diagnosis may be difficult due to marked fibrosis. Hodgkin's lymphoma should be considered in the differential diagnosis of thyroid neoplasms... - Case records of the Massachusetts General Hospital. Case 8-2006. A 71-year-old woman with Crohn's disease and altered mental statusDaniel K Podolsky
Gastrointestinal Unit, Massachusetts General Hospital, USA
N Engl J Med 354:1178-84. 2006 - Evaluation of bone marrow reticulin formation in chronic immune thrombocytopenia patients treated with romiplostimDavid J Kuter
Massachusetts General Hospital, Boston, MA 02114, USA
Blood 114:3748-56. 2009..These studies were registered at www.clinicaltrials.gov as #NCT00102323, #NCT00102336, #NCT00861224, and #NCT00116688... - Lymphocyte depleted Hodgkin lymphoma: an evaluation with immunophenotyping and genetic analysisGraham W Slack
The James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Leuk Lymphoma 50:937-43. 2009..The combined morphologic, immunophenotypic and molecular genetic features of this group of cases distinguish LDHL from other disease entities, including grey-zone lymphomas... - Myelodysplastic syndrome with isolated deletion of chromosome 20q: an indolent disease with minimal morphological dysplasia and frequent thrombocytopenic presentationRaavi Gupta
Department of Pathology, Columbia University Medical Center, New York, NY, USA
Br J Haematol 139:265-8. 2007..Cytogenetic analysis on adult patients undergoing bone marrow sampling for thrombocytopenia may help avoid misdiagnosis of MDS with del(20q) as ITP... - Philadelphia chromosome-positive acute myeloid leukemia: a rare aggressive leukemia with clinicopathologic features distinct from chronic myeloid leukemia in myeloid blast crisisChad P Soupir
The Departments of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
Am J Clin Pathol 127:642-50. 2007..5 months). The median survival of patients with Ph+ AML was 9 months, similar to that of patients with CML-MBC (7 months). Ph+ AML is a rare aggressive acute leukemia with some features distinct from CML-MBC... - Lymphoma of the ocular adnexa: A study of 353 casesJudith A Ferry
James Homer Wright Pathology Laboratories of the Massachusetts General Hospital, Massachusetts General Hospital, Boston, MA 02114, USA
Am J Surg Pathol 31:170-84. 2007..High-grade B-cell lymphomas only occasionally involve the ocular adnexa, and T-cell lymphoma, NK-cell lymphoma, and Hodgkin lymphoma are only rarely encountered in this site... - Bone progenitor dysfunction induces myelodysplasia and secondary leukaemiaMarc H G P Raaijmakers
Center for Regenerative Medicine, Massachusetts General Hospital and Harvard Medical School CPZN, USA
Nature 464:852-7. 2010..Furthermore, primary stromal dysfunction can result in secondary neoplastic disease, supporting the concept of niche-induced oncogenesis... - Acute myeloid leukemia and myelodysplastic syndromes after radiation therapy are similar to de novo disease and differ from other therapy-related myeloid neoplasmsValentina Nardi
Massachusetts General Hospital, 55 Fruit St, Warren 225, Boston, MA 02114, USA
J Clin Oncol 30:2340-7. 2012..XRT techniques have evolved in recent years and are associated with significantly reduced bone marrow exposure. The characteristics of post-XRT t-MN in the current era have not been studied... - Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 15-2004. A 31-year-old man with bilateral testicular enlargementKaren K Ballen
Division of Hematology and Oncology, Massachusetts General Hospital, USA
N Engl J Med 350:2081-7. 2004 - Co-occurrence of Langerhans cell histiocytosis and Rosai-Dorfman disease: possible relationship of two histiocytic disorders in rare casesDennis P O'Malley
Department of Pathology, Clarient, Aliso Viejo, CA 92656, USA
Mod Pathol 23:1616-23. 2010..Furthermore, we suggest on the basis of evidence from our cases that, when simultaneous, the two entities may be pathophysiologically related... - Case records of the Massachusetts General Hospital. Case 13-2006. A 50-year-old man with a painful bone mass and lesions in the liverAndrew X Zhu
Cancer Center, Massachusetts General Hospital, Boston, USA
N Engl J Med 354:1828-37. 2006 - Diffuse cellular and fibrosing interstitial pneumonitis with desquamative interstitial pneumonitis-like features associated with myeloid neoplasiaAlton B Farris
Pathology Service, Massachusetts General Hospital, Boston, MA, USA
Am J Surg Pathol 33:1485-93. 2009.... - Marginal zone B-cell lymphoma of the infratemporal fossa: a rare case and reviewMegan M Abbott
Harvard Medical School, Boston, Massachusetts, USA
Laryngoscope 120:2430-3. 2010..This type of lymphoma most commonly occurs in the stomach, but was found in the infratemporal fossa. This is the first report of an extranodal marginal zone B-cell lymphoma occurring in this location... - Case records of the Massachusetts General Hospital. Case 14-2006. A 25-year-old woman with anemia and iron overloadEyal C Attar
Center for Leukemia, Massachusetts General Hospital, Boston, USA
N Engl J Med 354:2047-56. 2006 - Case records of the Massachusetts General Hospital. Case 11-2007. A 59-year-old man with neck pain, weakness in the arms, and cranial-nerve palsiesDavid M Greer
Department of Neurology, Massachusetts General Hospital, USA
N Engl J Med 356:1561-70. 2007 - Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 10-2004. A 58-year-old man with acute myeloid leukemia and Fever after chemotherapyJay A Fishman
Transplant Infectious Disease and Compromised Host Program, Infectious Disease Division, Massachusetts General Hospital, USA
N Engl J Med 350:1339-47. 2004 - Low histologic grade follicular lymphoma with high proliferation index: morphologic and clinical featuresSa A Wang
Department of Pathology, Division of Hematology/Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Am J Surg Pathol 29:1490-6. 2005..In conclusion, LG-HPI FL appears to be a subgroup of FL with clinical behavior more akin to grade 3 FL. We propose that these LG-HPI FL cases should be classified separately from cases of low histologic grade FL with concordantly low PI... - Bone marrow fibrosis: pathophysiology and clinical significance of increased bone marrow stromal fibresDavid J Kuter
Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Br J Haematol 139:351-62. 2007..This suggests new avenues for investigation into the pathogenesis of various disorders associated with increased bone marrow stromal fibres... - Clinicopathologic analysis of follicular lymphoma occurring in childrenRobert B Lorsbach
Department of Pathology, St Jude Children s Research Hospital, 332 N Lauderdale Street, Memphis, TN 38105, USA
Blood 99:1959-64. 2002..However, bcl-2 expression in pediatric follicular lymphoma identifies a subset of patients in whom disease is often disseminated at clinical presentation and is more refractory to combination chemotherapy... - Primary follicular lymphoma of the testis and epididymis in adultsChris M Bacon
Department of Pathology, University of Cambridge, Box 231, Level 3 Lab Block, Addenbrooke s Hospital, Hills Road, Cambridge, CB2 2QQ, UK
Am J Surg Pathol 31:1050-8. 2007.... - ST1571 (imatinib mesylate) reduces bone marrow cellularity and normalizes morphologic features irrespective of cytogenetic responseRobert P Hasserjian
Dept of Pathology, Baystate Medical Center, Springfield, MA 01199, USA
Am J Clin Pathol 117:360-7. 2002..Thus, STI571 seems to affect the differentiation of CML cells in vivo, causing even extensively Philadelphia chromosome-positive hematopoiesis to exhibitfeatures resembling normal hematopoiesis...