Robert P Hasserjian

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. doi request reprint Acute myeloid leukemia: advances in diagnosis and classification
    R P Hasserjian
    Department of Pathology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Int J Lab Hematol 35:358-66. 2013
  2. ncbi request reprint Pathology of thymic tumors
    Robert P Hasserjian
    James Homer Wright Pathology Laboratories, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
    Semin Thorac Cardiovasc Surg 17:2-11. 2005
  3. ncbi request reprint Bone marrow findings correlate with clinical outcome in systemic AL amyloidosis patients
    R P Hasserjian
    James Homer Wright Pathology Laboratory, Department of Biostatistics, Massachusetts General Hospital, Boston, MA, USA
    Histopathology 50:567-73. 2007
  4. doi request reprint Reactive versus neoplastic bone marrow: problems and pitfalls
    Robert P Hasserjian
    Department of Pathology, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02115, USA
    Arch Pathol Lab Med 132:587-94. 2008
  5. doi request reprint Immunomodulator agent-related lymphoproliferative disorders
    Robert P Hasserjian
    Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
    Mod Pathol 22:1532-40. 2009
  6. pmc Acute erythroid leukemia: a reassessment using criteria refined in the 2008 WHO classification
    Robert P Hasserjian
    Department of Pathology, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA
    Blood 115:1985-92. 2010
  7. doi request reprint Clinicopathologic analysis of acute myeloid leukemia arising from chronic myelomonocytic leukemia
    Elizabeth L Courville
    Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
    Mod Pathol 26:751-61. 2013
  8. ncbi request reprint Pediatric-type nodal follicular lymphoma: an indolent clonal proliferation in children and adults with high proliferation index and no BCL2 rearrangement
    Abner Louissaint
    James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Boston, MA, USA
    Blood 120:2395-404. 2012
  9. pmc B-cell lymphomas with concurrent IGH-BCL2 and MYC rearrangements are aggressive neoplasms with clinical and pathologic features distinct from Burkitt lymphoma and diffuse large B-cell lymphoma
    Matija Snuderl
    Department of Pathology, James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Surg Pathol 34:327-40. 2010
  10. doi request reprint Nodular lymphocyte-predominant hodgkin lymphoma with atypical T cells: a morphologic variant mimicking peripheral T-cell lymphoma
    Aliyah R Sohani
    James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Boston, 02114, USA
    Am J Surg Pathol 35:1666-78. 2011

Detail Information

Publications53

  1. doi request reprint Acute myeloid leukemia: advances in diagnosis and classification
    R P Hasserjian
    Department of Pathology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Int J Lab Hematol 35:358-66. 2013
    ..It is anticipated that future leukemia classifications will employ a combination of karyotypic features and the gene mutation pattern to stratify patients to increasingly tailored treatment plans...
  2. ncbi request reprint Pathology of thymic tumors
    Robert P Hasserjian
    James Homer Wright Pathology Laboratories, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
    Semin Thorac Cardiovasc Surg 17:2-11. 2005
    ..Thorough histologic sampling and, in some cases, the appropriate use of ancillary studies such as immunohistochemistry, flow cytometry, and molecular studies, are important in proper pathologic evaluation of thymic tumors...
  3. ncbi request reprint Bone marrow findings correlate with clinical outcome in systemic AL amyloidosis patients
    R P Hasserjian
    James Homer Wright Pathology Laboratory, Department of Biostatistics, Massachusetts General Hospital, Boston, MA, USA
    Histopathology 50:567-73. 2007
    ..The aim was to determine if bone marrow pathological parameters at diagnosis were related to clinical behaviour in AL amyloidosis patients...
  4. doi request reprint Reactive versus neoplastic bone marrow: problems and pitfalls
    Robert P Hasserjian
    Department of Pathology, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02115, USA
    Arch Pathol Lab Med 132:587-94. 2008
    ....
  5. doi request reprint Immunomodulator agent-related lymphoproliferative disorders
    Robert P Hasserjian
    Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
    Mod Pathol 22:1532-40. 2009
    ..Further study is warranted to evaluate how these therapies interact with other immunosuppressive agents and the underlying abnormal immune system to enhance the development of lymphomas and atypical lymphoid proliferations...
  6. pmc Acute erythroid leukemia: a reassessment using criteria refined in the 2008 WHO classification
    Robert P Hasserjian
    Department of Pathology, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA
    Blood 115:1985-92. 2010
    ..Our findings suggest that AEL is in the continuum of MDS and AML with erythroid hyperplasia, where karyotype rather than an arbitrary blast cutoff represents the most important prognostic factor...
  7. doi request reprint Clinicopathologic analysis of acute myeloid leukemia arising from chronic myelomonocytic leukemia
    Elizabeth L Courville
    Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
    Mod Pathol 26:751-61. 2013
    ..The poor prognosis of these patients may be related to an older population and lack of favorable-prognosis karyotypes that characterize many de novo acute myeloid leukemia cases...
  8. ncbi request reprint Pediatric-type nodal follicular lymphoma: an indolent clonal proliferation in children and adults with high proliferation index and no BCL2 rearrangement
    Abner Louissaint
    James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Boston, MA, USA
    Blood 120:2395-404. 2012
    ..PFL-like cases also occur in adults and are associated with indolent behavior in this patient population...
  9. pmc B-cell lymphomas with concurrent IGH-BCL2 and MYC rearrangements are aggressive neoplasms with clinical and pathologic features distinct from Burkitt lymphoma and diffuse large B-cell lymphoma
    Matija Snuderl
    Department of Pathology, James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Surg Pathol 34:327-40. 2010
    ..The aggressive clinical behavior and combination of genetic abnormalities seen in these cases may warrant categorization as a separate entity in future classifications and call for novel therapeutic approaches...
  10. doi request reprint Nodular lymphocyte-predominant hodgkin lymphoma with atypical T cells: a morphologic variant mimicking peripheral T-cell lymphoma
    Aliyah R Sohani
    James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Boston, 02114, USA
    Am J Surg Pathol 35:1666-78. 2011
    ....
  11. doi request reprint Case records of the Massachusetts General Hospital. Case 8-2008. A 33-year-old man with fever, abdominal pain, and pancytopenia after renal transplantation
    Jeremy S Abramson
    Cancer Center, Massachusetts General Hospital, USA
    N Engl J Med 358:1176-87. 2008
  12. doi request reprint Beyond the lymphocyte predominant cell: CD4+CD8+ T-cells in nodular lymphocyte predominant Hodgkin lymphoma
    Aliyah Rahemtullah
    James Homer Wright Pathology Laboratories, Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Leuk Lymphoma 49:1870-8. 2008
    ..CD4+CD8+ T-cells have also been identified in the benign entity progressive transformation of germinal centres (PTGC), suggesting a possible relationship between NLPHL and PTGC...
  13. doi request reprint Infectious mononucleosis mimicking lymphoma: distinguishing morphological and immunophenotypic features
    Abner Louissaint
    The James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Boston, MA 02114, USA
    Mod Pathol 25:1149-59. 2012
    ....
  14. ncbi request reprint Primary follicular lymphoma of the gastrointestinal tract
    Joseph Misdraji
    The James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Am J Surg Pathol 35:1255-63. 2011
    ..Follicular lymphoma (FL), a common nodal lymphoma, is rare in the gastrointestinal (GI) tract. We report our experience with primary FL of the GI tract...
  15. ncbi request reprint Case records of the Massachusetts General Hospital. Case 16-2007. A 61-year-old man with a mediastinal mass
    Cameron D Wright
    Department of Surgery, Massachusetts General Hospital, USA
    N Engl J Med 356:2185-93. 2007
  16. ncbi request reprint Case records of the Massachusetts General Hospital. Case 33-2007. A 49-year-old HIV-positive man with anemia
    Eyal C Attar
    Hematology Oncology Unit, Massachusetts General Hospital, USA
    N Engl J Med 357:1745-54. 2007
  17. ncbi request reprint Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 2-2005. A 39-year-old woman with headache, stiff neck, and photophobia
    Karen K Ballen
    Division of Hematology and Oncology, Department of Medicine, Massachusetts General Hospital, USA
    N Engl J Med 352:274-83. 2005
  18. ncbi request reprint A double-positive CD4+CD8+ T-cell population is commonly found in nodular lymphocyte predominant Hodgkin lymphoma
    Aliyah Rahemtullah
    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Am J Clin Pathol 126:805-14. 2006
    ..This population may be a clue to the diagnosis of NLPHL, particularly in cases with limited tissue...
  19. doi request reprint Multiparameter immunophenotyping by flow cytometry in multiple myeloma: The diagnostic utility of defining ranges of normal antigenic expression in comparison to histology
    Elisa Cannizzo
    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    Cytometry B Clin Cytom 78:231-8. 2010
    ..These newly calculated normal ranges for each antigen were applied to our data, and compared to histologic and immunohistochemical findings...
  20. ncbi request reprint Case records of the Massachusetts General Hospital. Case 30-2006. A 41-year-old man with dyspnea, fever, and lymphadenopathy
    David T Scadden
    Department of Hematology Oncology, Massachusetts General Hospital, USA
    N Engl J Med 355:1358-68. 2006
  21. ncbi request reprint Aleukemic cutaneous myeloid sarcoma
    Amir Aboutalebi
    Department of Dermatology, Harvard Medical School, Boston, MA, USA
    J Cutan Pathol 40:996-1005. 2013
    ..The clinicopathologic diagnosis remains elusive due to isolated skin findings and variable immunostaining. Cytogenetic and molecular findings have infrequently been reported...
  22. ncbi request reprint NK-cell lymphomas and leukemias: a spectrum of tumors with variable manifestations and immunophenotype
    Robert P Hasserjian
    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Am J Clin Pathol 127:860-8. 2007
    ..Although some of these cases can be grouped into ENNK/T-NT, classification of tumors that have atypical or discordant features will remain controversial, particularly when EBV is absent...
  23. pmc Reassessment of small lymphocytic lymphoma in the era of monoclonal B-cell lymphocytosis
    Sarah E Gibson
    Department of Pathology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Haematologica 96:1144-52. 2011
    ..Minimal criteria of tissue involvement to separate small lymphocytic lymphoma from monoclonal B-cell lymphocytosis have not been defined...
  24. ncbi request reprint Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 19-2004. A 12-year-old boy with fatigue and eosinophilia
    Mary S Huang
    Division of Pediatric Oncology, Massachusetts General Hospital, USA
    N Engl J Med 350:2604-12. 2004
  25. ncbi request reprint Erythroid-predominant myelodysplastic syndromes: enumeration of blasts from nonerythroid rather than total marrow cells provides superior risk stratification
    Sa A Wang
    Department of Pathology, UMass Memorial Medical Center, University of Massachusetts, Worcester, MA, USA
    Mod Pathol 21:1394-402. 2008
    ..We conclude that in erythroid-predominant myelodysplastic syndrome, blast calculation as a proportion of marrow nonerythroid rather than total nucleated cells can better stratify patients into prognostically relevant groups...
  26. ncbi request reprint Case records of the Massachusetts General Hospital. Case 17-2006--a 34-year-old man with cavitary lung lesions
    Ephraim P Hochberg
    Division of Hematology and Oncology, Department of Medicine, Massachusetts General Hospital, USA
    N Engl J Med 354:2485-93. 2006
  27. doi request reprint FLT3 inhibitor-induced neutrophilic dermatosis
    Amir T Fathi
    Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA 02114, USA
    Blood 122:239-42. 2013
    ..FLT3 inhibition can lead to clinically distinct dermatoses, which suggests the effect of FLT3 inhibition on myeloid differentiation and a manifestation of a broader "syndrome" associated with this therapy. ..
  28. ncbi request reprint Castleman disease presenting in the neck: report of a case and review of the literature
    Sidharth V Puram
    Department of Otolaryngology, Division of Head and Neck Surgery, Massachusetts Eye and Ear Infirmary, Boston, MA, USA
    Am J Otolaryngol 34:239-44. 2013
    ..These findings stand in contrast to those observed in MCD patients, and hence, offer insight into the practical aspects of diagnosis and management of Castleman disease in the head and neck...
  29. doi request reprint Evaluation of bone marrow reticulin formation in chronic immune thrombocytopenia patients treated with romiplostim
    David J Kuter
    Massachusetts General Hospital, Boston, MA 02114, USA
    Blood 114:3748-56. 2009
    ..These studies were registered at www.clinicaltrials.gov as #NCT00102323, #NCT00102336, #NCT00861224, and #NCT00116688...
  30. ncbi request reprint Immunophenotypic changes and clinical outcome in B-cell lymphomas treated with rituximab
    Rania M Seliem
    Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Appl Immunohistochem Mol Morphol 14:18-23. 2006
    ..This study also underscores the importance of using a panel of antibodies to evaluate rituximab-treated B-NHL...
  31. pmc Phase II study of dasatinib in relapsed or refractory chronic lymphocytic leukemia
    Philip C Amrein
    Massachusetts General Hospital Cancer Center, Medical Oncology and Department of Biostatistics, Dana Farber Cancer Institute, Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Clin Cancer Res 17:2977-86. 2011
    ..Chronic lymphocytic leukemia (CLL) cells treated with dasatinib in vitro undergo apoptosis via inhibition of Lyn kinase. Thus, in this study we tested the activity of dasatinib in patients with relapsed CLL...
  32. ncbi request reprint Case records of the Massachusetts General Hospital. Case 8-2006. A 71-year-old woman with Crohn's disease and altered mental status
    Daniel K Podolsky
    Gastrointestinal Unit, Massachusetts General Hospital, USA
    N Engl J Med 354:1178-84. 2006
  33. ncbi request reprint Hodgkin's lymphoma of the thyroid: a clinicopathologic study of five cases and review of the literature
    Sa A Wang
    Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Mod Pathol 18:1577-84. 2005
    ..Histologic diagnosis may be difficult due to marked fibrosis. Hodgkin's lymphoma should be considered in the differential diagnosis of thyroid neoplasms...
  34. doi request reprint Lymphocyte depleted Hodgkin lymphoma: an evaluation with immunophenotyping and genetic analysis
    Graham W Slack
    The James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Leuk Lymphoma 50:937-43. 2009
    ..The combined morphologic, immunophenotypic and molecular genetic features of this group of cases distinguish LDHL from other disease entities, including grey-zone lymphomas...
  35. ncbi request reprint Lymphoma of the ocular adnexa: A study of 353 cases
    Judith A Ferry
    James Homer Wright Pathology Laboratories of the Massachusetts General Hospital, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Surg Pathol 31:170-84. 2007
    ..High-grade B-cell lymphomas only occasionally involve the ocular adnexa, and T-cell lymphoma, NK-cell lymphoma, and Hodgkin lymphoma are only rarely encountered in this site...
  36. ncbi request reprint Philadelphia chromosome-positive acute myeloid leukemia: a rare aggressive leukemia with clinicopathologic features distinct from chronic myeloid leukemia in myeloid blast crisis
    Chad P Soupir
    The Departments of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Clin Pathol 127:642-50. 2007
    ..5 months). The median survival of patients with Ph+ AML was 9 months, similar to that of patients with CML-MBC (7 months). Ph+ AML is a rare aggressive acute leukemia with some features distinct from CML-MBC...
  37. ncbi request reprint Myelodysplastic syndrome with isolated deletion of chromosome 20q: an indolent disease with minimal morphological dysplasia and frequent thrombocytopenic presentation
    Raavi Gupta
    Department of Pathology, Columbia University Medical Center, New York, NY, USA
    Br J Haematol 139:265-8. 2007
    ..Cytogenetic analysis on adult patients undergoing bone marrow sampling for thrombocytopenia may help avoid misdiagnosis of MDS with del(20q) as ITP...
  38. pmc Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia
    Marc H G P Raaijmakers
    Center for Regenerative Medicine, Massachusetts General Hospital and Harvard Medical School CPZN, USA
    Nature 464:852-7. 2010
    ..Furthermore, primary stromal dysfunction can result in secondary neoplastic disease, supporting the concept of niche-induced oncogenesis...
  39. doi request reprint Acute myeloid leukemia and myelodysplastic syndromes after radiation therapy are similar to de novo disease and differ from other therapy-related myeloid neoplasms
    Valentina Nardi
    Massachusetts General Hospital, 55 Fruit St, Warren 225, Boston, MA 02114, USA
    J Clin Oncol 30:2340-7. 2012
    ..XRT techniques have evolved in recent years and are associated with significantly reduced bone marrow exposure. The characteristics of post-XRT t-MN in the current era have not been studied...
  40. ncbi request reprint Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 15-2004. A 31-year-old man with bilateral testicular enlargement
    Karen K Ballen
    Division of Hematology and Oncology, Massachusetts General Hospital, USA
    N Engl J Med 350:2081-7. 2004
  41. doi request reprint Co-occurrence of Langerhans cell histiocytosis and Rosai-Dorfman disease: possible relationship of two histiocytic disorders in rare cases
    Dennis P O'Malley
    Department of Pathology, Clarient, Aliso Viejo, CA 92656, USA
    Mod Pathol 23:1616-23. 2010
    ..Furthermore, we suggest on the basis of evidence from our cases that, when simultaneous, the two entities may be pathophysiologically related...
  42. doi request reprint Diffuse cellular and fibrosing interstitial pneumonitis with desquamative interstitial pneumonitis-like features associated with myeloid neoplasia
    Alton B Farris
    Pathology Service, Massachusetts General Hospital, Boston, MA, USA
    Am J Surg Pathol 33:1485-93. 2009
    ..We conclude that preleukemic myeloid neoplasia can be associated with an interstitial pneumonitis with histopathologic features that are distinguishable from both leukemic infiltration and "usual" nonspecific interstitial pneumonia...
  43. ncbi request reprint Case records of the Massachusetts General Hospital. Case 13-2006. A 50-year-old man with a painful bone mass and lesions in the liver
    Andrew X Zhu
    Cancer Center, Massachusetts General Hospital, Boston, USA
    N Engl J Med 354:1828-37. 2006
  44. doi request reprint Marginal zone B-cell lymphoma of the infratemporal fossa: a rare case and review
    Megan M Abbott
    Harvard Medical School, Boston, Massachusetts, USA
    Laryngoscope 120:2430-3. 2010
    ..This type of lymphoma most commonly occurs in the stomach, but was found in the infratemporal fossa. This is the first report of an extranodal marginal zone B-cell lymphoma occurring in this location...
  45. ncbi request reprint Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 10-2004. A 58-year-old man with acute myeloid leukemia and Fever after chemotherapy
    Jay A Fishman
    Transplant Infectious Disease and Compromised Host Program, Infectious Disease Division, Massachusetts General Hospital, USA
    N Engl J Med 350:1339-47. 2004
  46. ncbi request reprint Case records of the Massachusetts General Hospital. Case 14-2006. A 25-year-old woman with anemia and iron overload
    Eyal C Attar
    Center for Leukemia, Massachusetts General Hospital, Boston, USA
    N Engl J Med 354:2047-56. 2006
  47. ncbi request reprint Case records of the Massachusetts General Hospital. Case 11-2007. A 59-year-old man with neck pain, weakness in the arms, and cranial-nerve palsies
    David M Greer
    Department of Neurology, Massachusetts General Hospital, USA
    N Engl J Med 356:1561-70. 2007
  48. ncbi request reprint Low histologic grade follicular lymphoma with high proliferation index: morphologic and clinical features
    Sa A Wang
    Department of Pathology, Division of Hematology Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Am J Surg Pathol 29:1490-6. 2005
    ..In conclusion, LG-HPI FL appears to be a subgroup of FL with clinical behavior more akin to grade 3 FL. We propose that these LG-HPI FL cases should be classified separately from cases of low histologic grade FL with concordantly low PI...
  49. ncbi request reprint Bone marrow fibrosis: pathophysiology and clinical significance of increased bone marrow stromal fibres
    David J Kuter
    Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Br J Haematol 139:351-62. 2007
    ..This suggests new avenues for investigation into the pathogenesis of various disorders associated with increased bone marrow stromal fibres...
  50. ncbi request reprint Clinicopathologic analysis of follicular lymphoma occurring in children
    Robert B Lorsbach
    Department of Pathology, St Jude Children s Research Hospital, 332 N Lauderdale Street, Memphis, TN 38105, USA
    Blood 99:1959-64. 2002
    ..However, bcl-2 expression in pediatric follicular lymphoma identifies a subset of patients in whom disease is often disseminated at clinical presentation and is more refractory to combination chemotherapy...
  51. ncbi request reprint ST1571 (imatinib mesylate) reduces bone marrow cellularity and normalizes morphologic features irrespective of cytogenetic response
    Robert P Hasserjian
    Dept of Pathology, Baystate Medical Center, Springfield, MA 01199, USA
    Am J Clin Pathol 117:360-7. 2002
    ..Thus, STI571 seems to affect the differentiation of CML cells in vivo, causing even extensively Philadelphia chromosome-positive hematopoiesis to exhibitfeatures resembling normal hematopoiesis...
  52. ncbi request reprint Primary follicular lymphoma of the testis and epididymis in adults
    Chris M Bacon
    Department of Pathology, University of Cambridge, Box 231, Level 3 Lab Block, Addenbrooke s Hospital, Hills Road, Cambridge, CB2 2QQ, UK
    Am J Surg Pathol 31:1050-8. 2007
    ....