Jacob H Hanna

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. pmc Direct cell reprogramming is a stochastic process amenable to acceleration
    Jacob Hanna
    The Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    Nature 462:595-601. 2009
  2. pmc Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs
    Jacob Hanna
    The Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 107:9222-7. 2010
  3. pmc Pluripotency and cellular reprogramming: facts, hypotheses, unresolved issues
    Jacob H Hanna
    The Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA
    Cell 143:508-25. 2010
  4. pmc Metastable pluripotent states in NOD-mouse-derived ESCs
    Jacob Hanna
    The Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Cell Stem Cell 4:513-24. 2009
  5. doi request reprint Reprogramming factor stoichiometry influences the epigenetic state and biological properties of induced pluripotent stem cells
    Bryce W Carey
    Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA
    Cell Stem Cell 9:588-98. 2011
  6. pmc Transgenic mice with defined combinations of drug-inducible reprogramming factors
    Styliani Markoulaki
    The Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nat Biotechnol 27:169-71. 2009
  7. pmc Dissecting direct reprogramming through integrative genomic analysis
    Tarjei S Mikkelsen
    Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 454:49-55. 2008
  8. pmc Direct reprogramming of terminally differentiated mature B lymphocytes to pluripotency
    Jacob Hanna
    The Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Cell 133:250-64. 2008
  9. pmc Reprogramming of murine and human somatic cells using a single polycistronic vector
    Bryce W Carey
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 106:157-62. 2009
  10. pmc H2AZ is enriched at polycomb complex target genes in ES cells and is necessary for lineage commitment
    Menno P Creyghton
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
    Cell 135:649-61. 2008

Collaborators

Detail Information

Publications14

  1. pmc Direct cell reprogramming is a stochastic process amenable to acceleration
    Jacob Hanna
    The Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    Nature 462:595-601. 2009
    ....
  2. pmc Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs
    Jacob Hanna
    The Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 107:9222-7. 2010
    ..The generation of validated "naïve" human ESCs will allow the molecular dissection of a previously undefined pluripotent state in humans and may open up new opportunities for patient-specific, disease-relevant research...
  3. pmc Pluripotency and cellular reprogramming: facts, hypotheses, unresolved issues
    Jacob H Hanna
    The Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA
    Cell 143:508-25. 2010
    ..Here we review recent advances in this rapidly moving field and emphasize unresolved and controversial questions...
  4. pmc Metastable pluripotent states in NOD-mouse-derived ESCs
    Jacob Hanna
    The Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Cell Stem Cell 4:513-24. 2009
    ..Our findings suggest that stem cells from different genetic backgrounds can assume distinct states of pluripotency in vitro, the stability of which is regulated by endogenous genetic determinants and can be modified by exogenous factors...
  5. doi request reprint Reprogramming factor stoichiometry influences the epigenetic state and biological properties of induced pluripotent stem cells
    Bryce W Carey
    Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA
    Cell Stem Cell 9:588-98. 2011
    ..This concept complicates efforts to define a "generic" epigenetic state of iPSCs and ESCs and should be considered when comparing different iPS and ES cell lines...
  6. pmc Transgenic mice with defined combinations of drug-inducible reprogramming factors
    Styliani Markoulaki
    The Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nat Biotechnol 27:169-71. 2009
    ..This approach creates a defined system for studying reprogramming mechanisms and allows screening of genetically homogeneous cells for compounds that can replace any transcription factor required for iPS cell derivation...
  7. pmc Dissecting direct reprogramming through integrative genomic analysis
    Tarjei S Mikkelsen
    Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 454:49-55. 2008
    ..We demonstrate that RNA inhibition of transcription factors can facilitate reprogramming, and that treatment with DNA methyltransferase inhibitors can improve the overall efficiency of the reprogramming process...
  8. pmc Direct reprogramming of terminally differentiated mature B lymphocytes to pluripotency
    Jacob Hanna
    The Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Cell 133:250-64. 2008
    ..Our study provides definite proof for the direct nuclear reprogramming of terminally differentiated adult cells to pluripotency...
  9. pmc Reprogramming of murine and human somatic cells using a single polycistronic vector
    Bryce W Carey
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 106:157-62. 2009
    ..In addition we have generated human induced pluripotent stem (hiPS) cell lines from human keratinocytes, demonstrating that a single polycistronic virus can reprogram human somatic cells...
  10. pmc H2AZ is enriched at polycomb complex target genes in ES cells and is necessary for lineage commitment
    Menno P Creyghton
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
    Cell 135:649-61. 2008
    ..Thus, H2AZ, together with PcG proteins, may establish specialized chromatin states in ES cells necessary for the proper execution of developmental gene expression programs...
  11. pmc Genome-scale DNA methylation maps of pluripotent and differentiated cells
    Alexander Meissner
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 454:766-70. 2008
    ..More generally, the results establish reduced representation bisulphite sequencing as a powerful technology for epigenetic profiling of cell populations relevant to developmental biology, cancer and regenerative medicine...
  12. pmc A drug-inducible transgenic system for direct reprogramming of multiple somatic cell types
    Marius Wernig
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nat Biotechnol 26:916-24. 2008
    ..This system facilitates the characterization of reprogramming and provides a tool for genetic or chemical screens to enhance reprogramming...
  13. ncbi request reprint Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin
    Jacob Hanna
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Science 318:1920-3. 2007
    ..The problems associated with using retroviruses and oncogenes for reprogramming need to be resolved before iPS cells can be considered for human therapy...
  14. pmc Single-gene transgenic mouse strains for reprogramming adult somatic cells
    Bryce W Carey
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, USA
    Nat Methods 7:56-9. 2010
    ..Because reprogramming factors are carried on a single polycistronic construct, the mice can be easily maintained, and the transgene can be easily transferred into other genetic backgrounds...