Sangyeul Han

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc Aberrant hyperactivation of akt and Mammalian target of rapamycin complex 1 signaling in sporadic chordomas
    Sangyeul Han
    Center for Human Genetic Research, Massachusetts General Hospital, Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Clin Cancer Res 15:1940-6. 2009
  2. doi Regulation of mTOR complex 2 signaling in neurofibromatosis 2-deficient target cell types
    Marianne F James
    Center for Human Genetic Research, Massachusetts General Hospital, Richard B Simches Research Building, 185 Cambridge Street, Boston, MA 02114, USA
    Mol Cancer Res 10:649-59. 2012
  3. pmc Pam (Protein associated with Myc) functions as an E3 ubiquitin ligase and regulates TSC/mTOR signaling
    Sangyeul Han
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
    Cell Signal 20:1084-91. 2008
  4. pmc NF2/merlin is a novel negative regulator of mTOR complex 1, and activation of mTORC1 is associated with meningioma and schwannoma growth
    Marianne F James
    Center for Human Genetic Research, Massachusetts General Hospital, Richard B Simches Research Building, 185 Cambridge St, Boston, MA 02114, USA
    Mol Cell Biol 29:4250-61. 2009
  5. pmc The E3 ubiquitin ligase protein associated with Myc (Pam) regulates mammalian/mechanistic target of rapamycin complex 1 (mTORC1) signaling in vivo through N- and C-terminal domains
    Sangyeul Han
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
    J Biol Chem 287:30063-72. 2012
  6. ncbi Alternative splicing in protein associated with Myc (Pam) influences its binding to c-Myc
    Túlio M Santos
    Molecular Neurogenetics Unit and Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Neurosci Res 83:222-32. 2006
  7. ncbi Phosphorylation of tuberin as a novel mechanism for somatic inactivation of the tuberous sclerosis complex proteins in brain lesions
    Sangyeul Han
    Molecular Neurogenetics Unit, Molecular Neuro Oncology, and Department of Neurology, Harvard Medical School Massachusetts General Hospital, Charlestown, Massachusetts, USA
    Cancer Res 64:812-6. 2004
  8. ncbi Pam and its ortholog highwire interact with and may negatively regulate the TSC1.TSC2 complex
    Vanishree Murthy
    Molecular Neurogenetics Unit, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Biol Chem 279:1351-8. 2004

Collaborators

Detail Information

Publications8

  1. pmc Aberrant hyperactivation of akt and Mammalian target of rapamycin complex 1 signaling in sporadic chordomas
    Sangyeul Han
    Center for Human Genetic Research, Massachusetts General Hospital, Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Clin Cancer Res 15:1940-6. 2009
    ..In this study, we investigated whether aberrant TSC/mammalian target of rapamycin complex 1 (mTORC1) signaling pathway is associated with sporadic chordomas...
  2. doi Regulation of mTOR complex 2 signaling in neurofibromatosis 2-deficient target cell types
    Marianne F James
    Center for Human Genetic Research, Massachusetts General Hospital, Richard B Simches Research Building, 185 Cambridge Street, Boston, MA 02114, USA
    Mol Cancer Res 10:649-59. 2012
    ..These studies may ultimately aid in the development of suitable therapeutics for NF2-associated tumors...
  3. pmc Pam (Protein associated with Myc) functions as an E3 ubiquitin ligase and regulates TSC/mTOR signaling
    Sangyeul Han
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
    Cell Signal 20:1084-91. 2008
    ....
  4. pmc NF2/merlin is a novel negative regulator of mTOR complex 1, and activation of mTORC1 is associated with meningioma and schwannoma growth
    Marianne F James
    Center for Human Genetic Research, Massachusetts General Hospital, Richard B Simches Research Building, 185 Cambridge St, Boston, MA 02114, USA
    Mol Cell Biol 29:4250-61. 2009
    ....
  5. pmc The E3 ubiquitin ligase protein associated with Myc (Pam) regulates mammalian/mechanistic target of rapamycin complex 1 (mTORC1) signaling in vivo through N- and C-terminal domains
    Sangyeul Han
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
    J Biol Chem 287:30063-72. 2012
    ..The ubiquitin ligase complex containing Pam-Fbxo45 likely targets additional synaptic and axonal proteins, which may explain the overlapping neurodevelopmental defects observed in Phr1 and Fbxo45 deficiency...
  6. ncbi Alternative splicing in protein associated with Myc (Pam) influences its binding to c-Myc
    Túlio M Santos
    Molecular Neurogenetics Unit and Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Neurosci Res 83:222-32. 2006
    ..The presence of Pam in many cellular compartments, its spliced variants, as well as its multiple binding partners, including tuberin, make it a complex, yet intriguing protein in the nervous system...
  7. ncbi Phosphorylation of tuberin as a novel mechanism for somatic inactivation of the tuberous sclerosis complex proteins in brain lesions
    Sangyeul Han
    Molecular Neurogenetics Unit, Molecular Neuro Oncology, and Department of Neurology, Harvard Medical School Massachusetts General Hospital, Charlestown, Massachusetts, USA
    Cancer Res 64:812-6. 2004
    ..These results have widespread implications for understanding the tissue specificity of tumor suppressor gene phenotypes...
  8. ncbi Pam and its ortholog highwire interact with and may negatively regulate the TSC1.TSC2 complex
    Vanishree Murthy
    Molecular Neurogenetics Unit, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Biol Chem 279:1351-8. 2004
    ..Therefore, we hypothesize that Pam, through its interaction with tuberin, could regulate the ubiquitination and proteasomal degradation of the tuberin-hamartin complex particularly in the CNS...