JOEL HABENER

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi request reprint A perspective on pancreatic stem/progenitor cells
    Joel F Habener
    Laboratory of Molecular Endocrinology, Massachusetts General Hospital, 55 Fruit Street WEL 320, Boston, MA 02114, USA
    Pediatr Diabetes 5:29-37. 2004
  2. ncbi request reprint Minireview: transcriptional regulation in pancreatic development
    Joel F Habener
    Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Howard Hughes Medical Institute, Harvard Medical School, 55 Fruit Street, WEL320, Boston, Massachusetts 02114, USA
    Endocrinology 146:1025-34. 2005
  3. doi request reprint Alpha cells come of age
    Joel F Habener
    Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Boston, MA 02114, USA
    Trends Endocrinol Metab 24:153-63. 2013
  4. pmc Α-cell role in β-cell generation and regeneration
    Joel F Habener
    Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Boston, MA, USA
    Islets 4:188-98. 2012
  5. ncbi request reprint Brn-4 transcription factor expression targeted to the early developing mouse pancreas induces ectopic glucagon gene expression in insulin-producing beta cells
    Mehboob A Hussain
    Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Biol Chem 277:16028-32. 2002
  6. ncbi request reprint Insulinotropic hormone glucagon-like peptide-1 differentiation of human pancreatic islet-derived progenitor cells into insulin-producing cells
    Elizabeth J Abraham
    Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
    Endocrinology 143:3152-61. 2002
  7. ncbi request reprint Triple genetic variation in the HNF-4alpha gene is associated with early-onset type 2 diabetes mellitus in a philippino family
    Claudia Gragnoli
    Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Metabolism 53:959-63. 2004
  8. ncbi request reprint IPF-1/MODY4 gene missense mutation in an Italian family with type 2 and gestational diabetes
    Claudia Gragnoli
    Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Boston, MA 02114, USA
    Metabolism 54:983-8. 2005
  9. pmc Snail2, a mediator of epithelial-mesenchymal transitions, expressed in progenitor cells of the developing endocrine pancreas
    J Michael Rukstalis
    Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Harvard Medical School and Howard Hughes Medical Institute, Boston, MA 02114, USA
    Gene Expr Patterns 7:471-9. 2007
  10. doi request reprint Alpha cells beget beta cells
    Zhengyu Liu
    Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Boston, MA 02114, USA
    Cell 138:424-6. 2009

Research Grants

  1. TRANSCRIPTION FACTORS AND THE ENDOCRINE PANCREAS
    JOEL HABENER; Fiscal Year: 2003
  2. GLUCAGON BIOSYNTHESIS & METABOLISM
    JOEL HABENER; Fiscal Year: 1992
  3. GLUCAGON BIOSYNTHESIS AND METABOLISM
    JOEL HABENER; Fiscal Year: 2007
  4. PANCREATIC ISLET-DERIVED STEM CELLS
    JOEL HABENER; Fiscal Year: 2002
  5. GLUCAGON BIOSYNTHESIS AND METABOLISM
    JOEL HABENER; Fiscal Year: 2002
  6. GLYCOPROTEIN HORMONE BIOSYNTHESIS AND ACTION
    JOEL HABENER; Fiscal Year: 2002
  7. GLUCAGON BIOSYNTHESIS AND METABOLISM
    JOEL HABENER; Fiscal Year: 1993
  8. BIOSYNTHESIS OF THYROID-STIMULATING HORMONE
    JOEL HABENER; Fiscal Year: 1992

Collaborators

Detail Information

Publications39

  1. ncbi request reprint A perspective on pancreatic stem/progenitor cells
    Joel F Habener
    Laboratory of Molecular Endocrinology, Massachusetts General Hospital, 55 Fruit Street WEL 320, Boston, MA 02114, USA
    Pediatr Diabetes 5:29-37. 2004
    ..This perspective discusses the potential applications of cellular medicines, in the new discipline of regenerative medicine, to achieve a cure for diabetes...
  2. ncbi request reprint Minireview: transcriptional regulation in pancreatic development
    Joel F Habener
    Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Howard Hughes Medical Institute, Harvard Medical School, 55 Fruit Street, WEL320, Boston, Massachusetts 02114, USA
    Endocrinology 146:1025-34. 2005
    ..An understanding of the importance of transcription factor genes during pancreas development has provided insights into the pathogenesis of diabetes, in which the mass of insulin-producing beta-cells is reduced...
  3. doi request reprint Alpha cells come of age
    Joel F Habener
    Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Boston, MA 02114, USA
    Trends Endocrinol Metab 24:153-63. 2013
    ..This circumstance prompts an examination of approaches to coax alpha cells to produce GLP-1 instead of glucagon...
  4. pmc Α-cell role in β-cell generation and regeneration
    Joel F Habener
    Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Boston, MA, USA
    Islets 4:188-98. 2012
    ..The trans-differentiation of pro-α-cells into β-cells provides a potentially exploitable mechanism for the regeneration of β-cells in individuals with type 1 diabetes...
  5. ncbi request reprint Brn-4 transcription factor expression targeted to the early developing mouse pancreas induces ectopic glucagon gene expression in insulin-producing beta cells
    Mehboob A Hussain
    Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Biol Chem 277:16028-32. 2002
    ..The early developmental expression of Brn-4 appears to be a dominant regulator of the glucagon expressing alpha cell lineage, even in the context of the beta cell lineage...
  6. ncbi request reprint Insulinotropic hormone glucagon-like peptide-1 differentiation of human pancreatic islet-derived progenitor cells into insulin-producing cells
    Elizabeth J Abraham
    Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
    Endocrinology 143:3152-61. 2002
    ..GLP-1 may be an important morphogen both for the embryonic development of the pancreas and for the neogenesis of beta-cells in the islets of the adult pancreas...
  7. ncbi request reprint Triple genetic variation in the HNF-4alpha gene is associated with early-onset type 2 diabetes mellitus in a philippino family
    Claudia Gragnoli
    Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Metabolism 53:959-63. 2004
    ..We suggest that the V199I missense mutation located in the ligand binding/dimerization domain of HNF-4alpha contributes to type 2 diabetes in the Philippine-1 family. The intron variations may contribute susceptibility to diabetes...
  8. ncbi request reprint IPF-1/MODY4 gene missense mutation in an Italian family with type 2 and gestational diabetes
    Claudia Gragnoli
    Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Boston, MA 02114, USA
    Metabolism 54:983-8. 2005
    ..Our findings suggest that the P33T IPF1 mutation may provide an increased susceptibility to the development of gestational diabetes and MODY4 in the Italy-6 pedigree...
  9. pmc Snail2, a mediator of epithelial-mesenchymal transitions, expressed in progenitor cells of the developing endocrine pancreas
    J Michael Rukstalis
    Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Harvard Medical School and Howard Hughes Medical Institute, Boston, MA 02114, USA
    Gene Expr Patterns 7:471-9. 2007
    ..EMT-like events appear to be involved in the development of the mammalian pancreas in vivo...
  10. doi request reprint Alpha cells beget beta cells
    Zhengyu Liu
    Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Boston, MA 02114, USA
    Cell 138:424-6. 2009
    ..Collombat et al. (2009) now show that in response to injury, a population of pancreatic progenitor cells can give rise to glucagon-expressing alpha cells that then transdifferentiate into beta cells...
  11. ncbi request reprint Regulation of Pax4 paired homeodomain gene by neuron-restrictive silencer factor
    Daniel M Kemp
    Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Biol Chem 278:35057-62. 2003
    ..Together with earlier reports, these new findings suggest an important functional role for NRSF in the expression of the pax4 gene and infer a role for NRSF in pancreatic islet development...
  12. doi request reprint Wnt signaling in pancreatic islets
    Zhengyu Liu
    Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Boston, MA 02114, USA
    Adv Exp Med Biol 654:391-419. 2010
    ..This review focuses on considerations of the hormonal regulation of Wnt signaling in islets and implications for mutations in components of the Wnt signaling pathway as a source for risk-associated alleles for type 2 diabetes...
  13. ncbi request reprint Huntington's disease of the endocrine pancreas: insulin deficiency and diabetes mellitus due to impaired insulin gene expression
    Ole A Andreassen
    Neurochemistry Laboratory, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Neurobiol Dis 11:410-24. 2002
    ....
  14. pmc Activation of pancreatic-duct-derived progenitor cells during pancreas regeneration in adult rats
    Wan Chun Li
    Section of Islet Transplantation and Cell Biology, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
    J Cell Sci 123:2792-802. 2010
    ..This mechanism of regeneration relies mainly on the plasticity of the differentiated cells within the pancreas...
  15. ncbi request reprint Nestin-positive progenitor cells derived from adult human pancreatic islets of Langerhans contain side population (SP) cells defined by expression of the ABCG2 (BCRP1) ATP-binding cassette transporter
    Andreas Lechner
    Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Howard Hughes Medical Institute, and Harvard Medical School, 55 Fruit Street WEL320, Boston, MA 02114, USA
    Biochem Biophys Res Commun 293:670-4. 2002
    ..Thus NIPs may be a potential source of adult pluripotential stem/progenitor cells useful for the production of islet tissue for transplantation into diabetic subjects...
  16. ncbi request reprint Transcription factor snail modulates hormone expression in established endocrine pancreatic cell lines
    J Michael Rukstalis
    Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Harvard Medical School, Howard Hughes Medical Institute, Boston, Massachusetts 02114, USA
    Endocrinology 147:2997-3006. 2006
    ..These findings may be relevant to providing approaches for the enhancement of beta-cell growth in individuals with diabetes mellitus...
  17. pmc Human pancreatic islet-derived progenitor cell engraftment in immunocompetent mice
    Elizabeth J Abraham
    Laboratory of Molecular Endocrinology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Am J Pathol 164:817-30. 2004
    ..We propose that a population of stem/progenitor cells isolated from the islets of the pancreas can cross xenogeneic transplantation immune barriers, induce tissue tolerance, and grow...
  18. ncbi request reprint Glucose-induced expression of the cyclin-dependent protein kinase 5 activator p35 involved in Alzheimer's disease regulates insulin gene transcription in pancreatic beta-cells
    Mariano Ubeda
    Laboratory of Molecular Endocrinology, Massachusetts General Hospital, 55 Fruit Street, Wellman 306, Boston, Massachusetts 02114, USA
    Endocrinology 145:3023-31. 2004
    ....
  19. ncbi request reprint Inhibition of cyclin-dependent kinase 5 activity protects pancreatic beta cells from glucotoxicity
    Mariano Ubeda
    Laboratory of Molecular Endocrinology, Harvard Medical School, Boston, MA 02115, USA
    J Biol Chem 281:28858-64. 2006
    ..These studies indicate that CDK5 plays a role in the loss of beta cell function under glucotoxic conditions and that CDK5 inhibitors could have therapeutic value for T2D...
  20. ncbi request reprint Redifferentiation of insulin-secreting cells after in vitro expansion of adult human pancreatic islet tissue
    Andreas Lechner
    Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Harvard Medical School, Howard Hughes Medical Institute, Boston, MA, USA
    Biochem Biophys Res Commun 327:581-8. 2005
    ..The in vitro generated cell clusters may be efficacious in providing islet-like tissue for transplantation into diabetic recipients...
  21. ncbi request reprint Cure of overt diabetes in NOD mice by transient treatment with anti-lymphocyte serum and exendin-4
    Norihiko Ogawa
    Transplant Center, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Diabetes 53:1700-5. 2004
    ..The addition of beta-cell growth factors, such as exendin-4, to immunotherapy protocols with anti-T-cell antibodies presents a potential novel approach to the cure of patients with new-onset type 1 diabetes...
  22. ncbi request reprint Synergistic effect of dimethyl sulfoxide on glucagon-like peptide 1 (GLP-1)-stimulated insulin secretion and gene transcription in INS-1 cells: characterization and implications
    Daniel M Kemp
    Laboratory of Molecular Endocrinology, Massachusetts General Hospital, 55 Fruit St, WEL320, Boston 02114, USA
    Biochem Pharmacol 64:689-97. 2002
    ....
  23. ncbi request reprint Pancreas duodenum homeobox-1 transcriptional activation requires interactions with p300
    Violeta Stanojevic
    Laboratory of Molecular Endocrinology and Diabetes Unit, Massachusetts General Hospital, Wellman 340, 50 Blossom Street, Boston, Massachusetts 02114, USA
    Endocrinology 145:2918-28. 2004
    ..Impairment of interactions between PDX-1 and p300 in pancreatic beta-cells may limit insulin production and lead to the development of diabetes...
  24. ncbi request reprint Developmental aspects of the endocrine pancreas
    Daniel M Kemp
    Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02114, USA
    Rev Endocr Metab Disord 4:5-17. 2003
  25. ncbi request reprint Glucagon-like peptide-1 receptor and proglucagon expression in mouse skin
    James F List
    Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02114, United States
    Regul Pept 134:149-57. 2006
    ..These findings suggest a possible paracrine/autocrine role for GLP-1 and its receptor in skin development and possibly also in folliculogenesis...
  26. ncbi request reprint Glucagon-like peptide 1 agonists and the development and growth of pancreatic beta-cells
    James F List
    Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Howard Hughes Medical Institute, 55 Fruit St, WEL 320, Boston, MA 02114, USA
    Am J Physiol Endocrinol Metab 286:E875-81. 2004
    ..Thus GLP-1 may be a means by which to create beta-cells ex vivo for transplantation into patients with insulinopenic type 1 diabetes and severe forms of type 2 diabetes...
  27. ncbi request reprint No evidence for significant transdifferentiation of bone marrow into pancreatic beta-cells in vivo
    Andreas Lechner
    Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Harvard Medical School and Howard Hughes Medical Institute, Boston, Massachusetts, USA
    Diabetes 53:616-23. 2004
    ..Thus our study results did not support the concept that bone marrow contributes significantly to adult pancreatic beta-cell renewal...
  28. ncbi request reprint CHOP transcription factor phosphorylation by casein kinase 2 inhibits transcriptional activation
    Mariano Ubeda
    Laboratory of Molecular Endocrinology, Massachusetts General Hospital and Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Biol Chem 278:40514-20. 2003
    ..Our findings suggest that inhibition of the proapoptotic functions of CHOP by CK2 may be a mechanism by which CK2 prevents apoptosis and promotes cellular proliferation...
  29. ncbi request reprint Stem/progenitor cells derived from adult tissues: potential for the treatment of diabetes mellitus
    Andreas Lechner
    Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02114, USA
    Am J Physiol Endocrinol Metab 284:E259-66. 2003
    ..If this can be achieved, the utilization of these cells for the generation of insulin-producing beta-cells in vitro seems to be feasible in the near future...
  30. ncbi request reprint Identification and functional characterization of melatonin Mel 1a receptors in pancreatic beta cells: potential role in incretin-mediated cell function by sensitization of cAMP signaling
    Daniel M Kemp
    Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Howard Hughes Medical Institute, Harvard Medical School, 55 Fruit Street WEL320, Boston, MA 02114, USA
    Mol Cell Endocrinol 191:157-66. 2002
    ..This phenomenon reflects observations reported in other cell types expressing the melatonin Mel 1a receptor, and may represent the first evidence of a specific physiological role for melatonin-induced sensitization...
  31. ncbi request reprint NRSF/REST confers transcriptional repression of the GPR10 gene via a putative NRSE/RE-1 located in the 5' promoter region
    Daniel M Kemp
    Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Howard Hughes Medical Institute, Harvard Medical School, 55 Fruit Street WEL320, Boston, MA 02114, USA
    FEBS Lett 531:193-8. 2002
    ..In conclusion, we demonstrate that the GPR10 gene is specifically regulated by NRSF, and suggest this to be a contributory factor in the tissue-specific distribution of GPR10 in vivo...
  32. doi request reprint Insulin-like actions of glucagon-like peptide-1: a dual receptor hypothesis
    Eva Tomas
    Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Boston, MA 02114, USA
    Trends Endocrinol Metab 21:59-67. 2010
    ..These findings have implications in nutrient assimilation, energy homeostasis, obesity, and the use of Dpp4 inhibitors for the treatment of diabetes...
  33. pmc Cytosolic adenylate kinases regulate K-ATP channel activity in human beta-cells
    Violeta Stanojevic
    Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Biochem Biophys Res Commun 368:614-9. 2008
    ..The down-regulation of AK1 expression by hyperglycemia may contribute to the defective coupling of glucose metabolism to K-ATP channel activity in type 2 diabetes...
  34. pmc Glucagon-like peptide-1 activation of TCF7L2-dependent Wnt signaling enhances pancreatic beta cell proliferation
    Zhengyu Liu
    Laboratory of Molecular Endocrinology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Biol Chem 283:8723-35. 2008
    ..Wnt signaling appears to mediate GLP-1-induced beta cell proliferation raising possibilities for novel treatments of diabetes...
  35. ncbi request reprint Stromal cell derived factor-1 (SDF-1)/CXCL12 attenuates diabetes in mice and promotes pancreatic beta-cell survival by activation of the prosurvival kinase Akt
    Tatsuya Yano
    Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Diabetes 56:2946-57. 2007
    ..We determined whether stromal cell-derived factor (SDF)-1/CXCL12 and its receptor, CX chemokine receptor (CXCR)4, are important for the survival of beta-cells...
  36. ncbi request reprint Islets break off from the mainland
    J Michael Rukstalis
    Nat Med 12:273-4. 2006
  37. ncbi request reprint Bone marrow stem cells find a path to the pancreas
    Andreas Lechner
    Nat Biotechnol 21:755-6. 2003
  38. ncbi request reprint Effects of 3 months of continuous subcutaneous administration of glucagon-like peptide 1 in elderly patients with type 2 diabetes
    Graydon S Meneilly
    Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    Diabetes Care 26:2835-41. 2003
    ..We conducted a 3-month trial to determine the efficacy and safety of GLP-1 in elderly diabetic patients...
  39. ncbi request reprint Glucagon-like peptide-1 augments insulin-mediated glucose uptake in the obese state
    Josephine M Egan
    Diabetes Section, Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Clin Endocrinol Metab 87:3768-73. 2002
    ..However, the rate of disappearance of glucose during the GLP-1 study was significantly higher (P = 0.033) than during the insulin study. We conclude that in insulin-resistant states, GLP-1 has insulinomimetic properties per se...

Research Grants41

  1. TRANSCRIPTION FACTORS AND THE ENDOCRINE PANCREAS
    JOEL HABENER; Fiscal Year: 2003
    ....
  2. GLUCAGON BIOSYNTHESIS & METABOLISM
    JOEL HABENER; Fiscal Year: 1992
    ..These investigations have potential relevance to an understanding of cellular differentiation and the pathogenesis of diabetes mellitus...
  3. GLUCAGON BIOSYNTHESIS AND METABOLISM
    JOEL HABENER; Fiscal Year: 2007
    ....
  4. PANCREATIC ISLET-DERIVED STEM CELLS
    JOEL HABENER; Fiscal Year: 2002
    ..As proposed in this application, transplantation of NIPs directly into the pancreata of STZ-induced and NOD diabetic mice will differentiate NIPs into Beta-cells and permanently cure the diabetes. ..
  5. GLUCAGON BIOSYNTHESIS AND METABOLISM
    JOEL HABENER; Fiscal Year: 2002
    ..We propose that the results forthcoming from the experimental plan presented may provide insights into the design of rational, novel therapeutic approaches for the treatment and possibly an eventual cure for diabetes mellitus. ..
  6. GLYCOPROTEIN HORMONE BIOSYNTHESIS AND ACTION
    JOEL HABENER; Fiscal Year: 2002
    ..These studies have potential relevance to understanding the molecular mechanisms controlling spermatogenesis and fertility. ..
  7. GLUCAGON BIOSYNTHESIS AND METABOLISM
    JOEL HABENER; Fiscal Year: 1993
    ....
  8. BIOSYNTHESIS OF THYROID-STIMULATING HORMONE
    JOEL HABENER; Fiscal Year: 1992
    ..A major long-term goal of these studies is to utilize this understanding of the molecular and cellular biology of glycoprotein hormone gene expression to provide an understanding of human disease...