Research Topics
Species | JOEL HABENERSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
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Publications
Α-cell role in β-cell generation and regenerationJoel F Habener
Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Boston, MA, USA
Islets 4:188-98. 2012..The trans-differentiation of pro-α-cells into β-cells provides a potentially exploitable mechanism for the regeneration of β-cells in individuals with type 1 diabetes...
Minireview: transcriptional regulation in pancreatic developmentJoel F Habener
Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Howard Hughes Medical Institute, Harvard Medical School, 55 Fruit Street, WEL320, Boston, Massachusetts 02114, USA
Endocrinology 146:1025-34. 2005..An understanding of the importance of transcription factor genes during pancreas development has provided insights into the pathogenesis of diabetes, in which the mass of insulin-producing beta-cells is reduced...- A perspective on pancreatic stem/progenitor cellsJoel F Habener
Laboratory of Molecular Endocrinology, Massachusetts General Hospital, 55 Fruit Street WEL 320, Boston, MA 02114, USA
Pediatr Diabetes 5:29-37. 2004..This perspective discusses the potential applications of cellular medicines, in the new discipline of regenerative medicine, to achieve a cure for diabetes... - Brn-4 transcription factor expression targeted to the early developing mouse pancreas induces ectopic glucagon gene expression in insulin-producing beta cellsMehboob A Hussain
Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02114, USA
J Biol Chem 277:16028-32. 2002..The early developmental expression of Brn-4 appears to be a dominant regulator of the glucagon expressing alpha cell lineage, even in the context of the beta cell lineage... - Insulinotropic hormone glucagon-like peptide-1 differentiation of human pancreatic islet-derived progenitor cells into insulin-producing cellsElizabeth J Abraham
Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
Endocrinology 143:3152-61. 2002..GLP-1 may be an important morphogen both for the embryonic development of the pancreas and for the neogenesis of beta-cells in the islets of the adult pancreas... - Triple genetic variation in the HNF-4alpha gene is associated with early-onset type 2 diabetes mellitus in a philippino familyClaudia Gragnoli
Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
Metabolism 53:959-63. 2004..We suggest that the V199I missense mutation located in the ligand binding/dimerization domain of HNF-4alpha contributes to type 2 diabetes in the Philippine-1 family. The intron variations may contribute susceptibility to diabetes... 
Alpha cells beget beta cellsZhengyu Liu
Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Boston, MA 02114, USA
Cell 138:424-6. 2009..Collombat et al. (2009) now show that in response to injury, a population of pancreatic progenitor cells can give rise to glucagon-expressing alpha cells that then transdifferentiate into beta cells...- Nestin-positive progenitor cells derived from adult human pancreatic islets of Langerhans contain side population (SP) cells defined by expression of the ABCG2 (BCRP1) ATP-binding cassette transporterAndreas Lechner
Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Howard Hughes Medical Institute, and Harvard Medical School, 55 Fruit Street-WEL320, Boston, MA 02114, USA
Biochem Biophys Res Commun 293:670-4. 2002..Thus NIPs may be a potential source of adult pluripotential stem/progenitor cells useful for the production of islet tissue for transplantation into diabetic subjects... - IPF-1/MODY4 gene missense mutation in an Italian family with type 2 and gestational diabetesClaudia Gragnoli
Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Boston, MA 02114, USA
Metabolism 54:983-8. 2005..Our findings suggest that the P33T IPF1 mutation may provide an increased susceptibility to the development of gestational diabetes and MODY4 in the Italy-6 pedigree... - Wnt signaling in pancreatic isletsZhengyu Liu
Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Boston, MA 02114, USA
Adv Exp Med Biol 654:391-419. 2010..This review focuses on considerations of the hormonal regulation of Wnt signaling in islets and implications for mutations in components of the Wnt signaling pathway as a source for risk-associated alleles for type 2 diabetes... - Regulation of Pax4 paired homeodomain gene by neuron-restrictive silencer factorDaniel M Kemp
Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02114, USA
J Biol Chem 278:35057-62. 2003..Together with earlier reports, these new findings suggest an important functional role for NRSF in the expression of the pax4 gene and infer a role for NRSF in pancreatic islet development... - Huntington's disease of the endocrine pancreas: insulin deficiency and diabetes mellitus due to impaired insulin gene expressionOle A Andreassen
Neurochemistry Laboratory, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Neurobiol Dis 11:410-24. 2002.... - Activation of pancreatic-duct-derived progenitor cells during pancreas regeneration in adult ratsWan Chun Li
Section of Islet Transplantation and Cell Biology, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
J Cell Sci 123:2792-802. 2010..This mechanism of regeneration relies mainly on the plasticity of the differentiated cells within the pancreas... - Snail2, a mediator of epithelial-mesenchymal transitions, expressed in progenitor cells of the developing endocrine pancreasJ Michael Rukstalis
Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Harvard Medical School and Howard Hughes Medical Institute, Boston, MA 02114, USA
Gene Expr Patterns 7:471-9. 2007..EMT-like events appear to be involved in the development of the mammalian pancreas in vivo... - Transcription factor snail modulates hormone expression in established endocrine pancreatic cell linesJ Michael Rukstalis
Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Harvard Medical School, Howard Hughes Medical Institute, Boston, Massachusetts 02114, USA
Endocrinology 147:2997-3006. 2006..These findings may be relevant to providing approaches for the enhancement of beta-cell growth in individuals with diabetes mellitus... - Glucose-induced expression of the cyclin-dependent protein kinase 5 activator p35 involved in Alzheimer's disease regulates insulin gene transcription in pancreatic beta-cellsMariano Ubeda
Laboratory of Molecular Endocrinology, Massachusetts General Hospital, 55 Fruit Street, Wellman 306, Boston, Massachusetts 02114, USA
Endocrinology 145:3023-31. 2004.... - Human pancreatic islet-derived progenitor cell engraftment in immunocompetent miceElizabeth J Abraham
Laboratory of Molecular Endocrinology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Am J Pathol 164:817-30. 2004..We propose that a population of stem/progenitor cells isolated from the islets of the pancreas can cross xenogeneic transplantation immune barriers, induce tissue tolerance, and grow... - Inhibition of cyclin-dependent kinase 5 activity protects pancreatic beta cells from glucotoxicityMariano Ubeda
Laboratory of Molecular Endocrinology, Harvard Medical School, Boston, MA 02115, USA
J Biol Chem 281:28858-64. 2006..These studies indicate that CDK5 plays a role in the loss of beta cell function under glucotoxic conditions and that CDK5 inhibitors could have therapeutic value for T2D... - Redifferentiation of insulin-secreting cells after in vitro expansion of adult human pancreatic islet tissueAndreas Lechner
Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Harvard Medical School, Howard Hughes Medical Institute, Boston, MA, USA
Biochem Biophys Res Commun 327:581-8. 2005..The in vitro generated cell clusters may be efficacious in providing islet-like tissue for transplantation into diabetic recipients... - Cure of overt diabetes in NOD mice by transient treatment with anti-lymphocyte serum and exendin-4Norihiko Ogawa
Transplant Center, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
Diabetes 53:1700-5. 2004..The addition of beta-cell growth factors, such as exendin-4, to immunotherapy protocols with anti-T-cell antibodies presents a potential novel approach to the cure of patients with new-onset type 1 diabetes... - Pancreas duodenum homeobox-1 transcriptional activation requires interactions with p300Violeta Stanojevic
Laboratory of Molecular Endocrinology and Diabetes Unit, Massachusetts General Hospital, Wellman 340, 50 Blossom Street, Boston, Massachusetts 02114, USA
Endocrinology 145:2918-28. 2004..Impairment of interactions between PDX-1 and p300 in pancreatic beta-cells may limit insulin production and lead to the development of diabetes... - Synergistic effect of dimethyl sulfoxide on glucagon-like peptide 1 (GLP-1)-stimulated insulin secretion and gene transcription in INS-1 cells: characterization and implicationsDaniel M Kemp
Laboratory of Molecular Endocrinology, Massachusetts General Hospital, 55 Fruit St, WEL320, Boston 02114, USA
Biochem Pharmacol 64:689-97. 2002.... - Developmental aspects of the endocrine pancreasDaniel M Kemp
Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02114, USA
Rev Endocr Metab Disord 4:5-17. 2003 - Glucagon-like peptide 1 agonists and the development and growth of pancreatic beta-cellsJames F List
Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Howard Hughes Medical Institute, 55 Fruit St, WEL 320, Boston, MA 02114, USA
Am J Physiol Endocrinol Metab 286:E875-81. 2004..Thus GLP-1 may be a means by which to create beta-cells ex vivo for transplantation into patients with insulinopenic type 1 diabetes and severe forms of type 2 diabetes... - No evidence for significant transdifferentiation of bone marrow into pancreatic beta-cells in vivoAndreas Lechner
Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Harvard Medical School and Howard Hughes Medical Institute, Boston, Massachusetts, USA
Diabetes 53:616-23. 2004..Thus our study results did not support the concept that bone marrow contributes significantly to adult pancreatic beta-cell renewal... - CHOP transcription factor phosphorylation by casein kinase 2 inhibits transcriptional activationMariano Ubeda
Laboratory of Molecular Endocrinology, Massachusetts General Hospital and Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02114, USA
J Biol Chem 278:40514-20. 2003..Our findings suggest that inhibition of the proapoptotic functions of CHOP by CK2 may be a mechanism by which CK2 prevents apoptosis and promotes cellular proliferation... - Stem/progenitor cells derived from adult tissues: potential for the treatment of diabetes mellitusAndreas Lechner
Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02114, USA
Am J Physiol Endocrinol Metab 284:E259-66. 2003..If this can be achieved, the utilization of these cells for the generation of insulin-producing beta-cells in vitro seems to be feasible in the near future... - Glucagon-like peptide-1 receptor and proglucagon expression in mouse skinJames F List
Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02114, United States
Regul Pept 134:149-57. 2006..These findings suggest a possible paracrine/autocrine role for GLP-1 and its receptor in skin development and possibly also in folliculogenesis... - Cytosolic adenylate kinases regulate K-ATP channel activity in human beta-cellsVioleta Stanojevic
Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Biochem Biophys Res Commun 368:614-9. 2008..The down-regulation of AK1 expression by hyperglycemia may contribute to the defective coupling of glucose metabolism to K-ATP channel activity in type 2 diabetes... - Insulin-like actions of glucagon-like peptide-1: a dual receptor hypothesisEva Tomas
Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Boston, MA 02114, USA
Trends Endocrinol Metab 21:59-67. 2010..These findings have implications in nutrient assimilation, energy homeostasis, obesity, and the use of Dpp4 inhibitors for the treatment of diabetes... - Glucagon-like peptide-1 activation of TCF7L2-dependent Wnt signaling enhances pancreatic beta cell proliferationZhengyu Liu
Laboratory of Molecular Endocrinology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
J Biol Chem 283:8723-35. 2008..Wnt signaling appears to mediate GLP-1-induced beta cell proliferation raising possibilities for novel treatments of diabetes... - Stromal cell derived factor-1 (SDF-1)/CXCL12 attenuates diabetes in mice and promotes pancreatic beta-cell survival by activation of the prosurvival kinase AktTatsuya Yano
Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Diabetes 56:2946-57. 2007..We determined whether stromal cell-derived factor (SDF)-1/CXCL12 and its receptor, CX chemokine receptor (CXCR)4, are important for the survival of beta-cells... - Identification and functional characterization of melatonin Mel 1a receptors in pancreatic beta cells: potential role in incretin-mediated cell function by sensitization of cAMP signalingDaniel M Kemp
Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Howard Hughes Medical Institute, Harvard Medical School, 55 Fruit Street WEL320, Boston, MA 02114, USA
Mol Cell Endocrinol 191:157-66. 2002..This phenomenon reflects observations reported in other cell types expressing the melatonin Mel 1a receptor, and may represent the first evidence of a specific physiological role for melatonin-induced sensitization... - NRSF/REST confers transcriptional repression of the GPR10 gene via a putative NRSE/RE-1 located in the 5' promoter regionDaniel M Kemp
Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Howard Hughes Medical Institute, Harvard Medical School, 55 Fruit Street WEL320, Boston, MA 02114, USA
FEBS Lett 531:193-8. 2002..In conclusion, we demonstrate that the GPR10 gene is specifically regulated by NRSF, and suggest this to be a contributory factor in the tissue-specific distribution of GPR10 in vivo... - Islets break off from the mainlandJ Michael Rukstalis
Nat Med 12:273-4. 2006 - Effects of 3 months of continuous subcutaneous administration of glucagon-like peptide 1 in elderly patients with type 2 diabetesGraydon S Meneilly
Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
Diabetes Care 26:2835-41. 2003..Although plasma ghrelin levels decreased during both portions of the clamp, a drug effect was not present. CONCLUSIONS: A GLP-1 compound is a promising therapeutic option for elderly diabetic patients... - Bone marrow stem cells find a path to the pancreasAndreas Lechner
Nat Biotechnol 21:755-6. 2003 - Glucagon-like peptide-1 augments insulin-mediated glucose uptake in the obese stateJosephine M Egan
Diabetes Section, Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
J Clin Endocrinol Metab 87:3768-73. 2002..However, the rate of disappearance of glucose during the GLP-1 study was significantly higher (P = 0.033) than during the insulin study. We conclude that in insulin-resistant states, GLP-1 has insulinomimetic properties per se...
Research Grants
- TRANSCRIPTION FACTORS AND THE ENDOCRINE PANCREASJOEL HABENER; Fiscal Year: 2003....
- GLUCAGON BIOSYNTHESIS & METABOLISMJOEL HABENER; Fiscal Year: 1992..These investigations have potential relevance to an understanding of cellular differentiation and the pathogenesis of diabetes mellitus...
- GLUCAGON BIOSYNTHESIS AND METABOLISMJOEL HABENER; Fiscal Year: 2007....
- PANCREATIC ISLET-DERIVED STEM CELLSJOEL HABENER; Fiscal Year: 2002..As proposed in this application, transplantation of NIPs directly into the pancreata of STZ-induced and NOD diabetic mice will differentiate NIPs into Beta-cells and permanently cure the diabetes. ..
- GLUCAGON BIOSYNTHESIS AND METABOLISMJOEL HABENER; Fiscal Year: 2002..We propose that the results forthcoming from the experimental plan presented may provide insights into the design of rational, novel therapeutic approaches for the treatment and possibly an eventual cure for diabetes mellitus. ..
- GLYCOPROTEIN HORMONE BIOSYNTHESIS AND ACTIONJOEL HABENER; Fiscal Year: 2002..These studies have potential relevance to understanding the molecular mechanisms controlling spermatogenesis and fertility. ..
- GLUCAGON BIOSYNTHESIS AND METABOLISMJOEL HABENER; Fiscal Year: 1993....
- BIOSYNTHESIS OF THYROID-STIMULATING HORMONEJOEL HABENER; Fiscal Year: 1992..A major long-term goal of these studies is to utilize this understanding of the molecular and cellular biology of glycoprotein hormone gene expression to provide an understanding of human disease...