Mitchell Guttman

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. pmc Assessing the significance of conserved genomic aberrations using high resolution genomic microarrays
    Mitchell Guttman
    Penn Center for Bioinformatics, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS Genet 3:e143. 2007
  2. pmc Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals
    Mitchell Guttman
    Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 458:223-7. 2009
  3. pmc A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response
    Maite Huarte
    The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
    Cell 142:409-19. 2010
  4. doi request reprint Modular regulatory principles of large non-coding RNAs
    Mitchell Guttman
    Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 482:339-46. 2012
  5. pmc lincRNAs act in the circuitry controlling pluripotency and differentiation
    Mitchell Guttman
    Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 477:295-300. 2011
  6. pmc Ab initio reconstruction of cell type-specific transcriptomes in mouse reveals the conserved multi-exonic structure of lincRNAs
    Mitchell Guttman
    Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
    Nat Biotechnol 28:503-10. 2010
  7. pmc Unbiased reconstruction of a mammalian transcriptional network mediating pathogen responses
    Ido Amit
    Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA
    Science 326:257-63. 2009
  8. pmc A high-throughput chromatin immunoprecipitation approach reveals principles of dynamic gene regulation in mammals
    Manuel Garber
    Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
    Mol Cell 47:810-22. 2012
  9. pmc A high-resolution map of human evolutionary constraint using 29 mammals
    Kerstin Lindblad-Toh
    Broad Institute of Harvard and Massachusetts Institute of Technology, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 478:476-82. 2011
  10. pmc Large intergenic non-coding RNA-RoR modulates reprogramming of human induced pluripotent stem cells
    Sabine Loewer
    Stem Cell Transplantation Program, Division of Pediatric Hematology and Oncology, Manton Center for Orphan Disease Research, Children s Hospital Boston and Dana Farber Cancer Institute, Boston, Massachusetts, USA
    Nat Genet 42:1113-7. 2010

Detail Information

Publications16

  1. pmc Assessing the significance of conserved genomic aberrations using high resolution genomic microarrays
    Mitchell Guttman
    Penn Center for Bioinformatics, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS Genet 3:e143. 2007
    ..The algorithm has been fully implemented and tested and is freely available as a Java application at http://www.cbil.upenn.edu/MSA...
  2. pmc Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals
    Mitchell Guttman
    Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 458:223-7. 2009
    ..Together, these results define a unique collection of functional lincRNAs that are highly conserved and implicated in diverse biological processes...
  3. pmc A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response
    Maite Huarte
    The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
    Cell 142:409-19. 2010
    ..We propose a model whereby transcription factors activate lincRNAs that serve as key repressors by physically associating with repressive complexes and modulate their localization to sets of previously active genes...
  4. doi request reprint Modular regulatory principles of large non-coding RNAs
    Mitchell Guttman
    Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 482:339-46. 2012
    ..Here we synthesize these studies to provide an emerging model whereby large ncRNAs might achieve regulatory specificity through modularity, assembling diverse combinations of proteins and possibly RNA and DNA interactions...
  5. pmc lincRNAs act in the circuitry controlling pluripotency and differentiation
    Mitchell Guttman
    Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 477:295-300. 2011
    ..Together, the results demonstrate that lincRNAs have key roles in the circuitry controlling ES cell state...
  6. pmc Ab initio reconstruction of cell type-specific transcriptomes in mouse reveals the conserved multi-exonic structure of lincRNAs
    Mitchell Guttman
    Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
    Nat Biotechnol 28:503-10. 2010
    ..Our results open the way to direct experimental manipulation of thousands of noncoding RNAs and demonstrate the power of ab initio reconstruction to render a comprehensive picture of mammalian transcriptomes...
  7. pmc Unbiased reconstruction of a mammalian transcriptional network mediating pathogen responses
    Ido Amit
    Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA
    Science 326:257-63. 2009
    ..This study establishes a broadly applicable, comprehensive, and unbiased approach to reveal the wiring and functions of a regulatory network controlling a major transcriptional response in primary mammalian cells...
  8. pmc A high-throughput chromatin immunoprecipitation approach reveals principles of dynamic gene regulation in mammals
    Manuel Garber
    Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
    Mol Cell 47:810-22. 2012
    ....
  9. pmc A high-resolution map of human evolutionary constraint using 29 mammals
    Kerstin Lindblad-Toh
    Broad Institute of Harvard and Massachusetts Institute of Technology, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 478:476-82. 2011
    ..Overlap with disease-associated variants indicates that our findings will be relevant for studies of human biology, health and disease...
  10. pmc Large intergenic non-coding RNA-RoR modulates reprogramming of human induced pluripotent stem cells
    Sabine Loewer
    Stem Cell Transplantation Program, Division of Pediatric Hematology and Oncology, Manton Center for Orphan Disease Research, Children s Hospital Boston and Dana Farber Cancer Institute, Boston, Massachusetts, USA
    Nat Genet 42:1113-7. 2010
    ....
  11. doi request reprint Computational methods for transcriptome annotation and quantification using RNA-seq
    Manuel Garber
    Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts, USA
    Nat Methods 8:469-77. 2011
    ..Finally, we highlight the interdependence between these categories and discuss the benefits for different biological applications...
  12. pmc Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression
    Ahmad M Khalil
    The Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 106:11667-72. 2009
    ..We propose a model in which some lincRNAs guide chromatin-modifying complexes to specific genomic loci to regulate gene expression...
  13. pmc Digital transcriptome profiling from attomole-level RNA samples
    Fatih Ozsolak
    Helicos BioSciences Corporation, Cambridge, MA 02139, USA
    Genome Res 20:519-25. 2010
    ....
  14. pmc Transcriptional and epigenetic dynamics during specification of human embryonic stem cells
    Casey A Gifford
    Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
    Cell 153:1149-63. 2013
    ....
  15. pmc The Xist lncRNA exploits three-dimensional genome architecture to spread across the X chromosome
    Jesse M Engreitz
    Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA
    Science 341:1237973. 2013
    ..These findings suggest a model in which Xist coats the X chromosome by searching in three dimensions, modifying chromosome structure, and spreading to newly accessible locations...
  16. pmc Identifying novel constrained elements by exploiting biased substitution patterns
    Manuel Garber
    Department of Biology, Broad Institute of MIT and Harvard, 7 Cambridge Center, MIT, Cambridge, MA 02142, USA
    Bioinformatics 25:i54-62. 2009
    ..Many methods have been developed to identify conserved sequences across species; however, existing methods only model conservation as a decrease in the rate of mutation and have ignored selection acting on the pattern of mutations...