Piyush B Gupta

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. pmc Cell-state transitions regulated by SLUG are critical for tissue regeneration and tumor initiation
    Sarah Phillips
    Department of Developmental, Molecular and Chemical Biology, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA Molecular Oncology Research Institute, Tufts Medical Center, 800 Washington Street, Boston, MA 02111, USA
    Stem Cell Reports 2:633-47. 2014
  2. doi request reprint Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells
    Piyush B Gupta
    Broad Institute, Cambridge, MA 02142, USA
    Cell 146:633-44. 2011
  3. doi request reprint Identification of selective inhibitors of cancer stem cells by high-throughput screening
    Piyush B Gupta
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 138:645-59. 2009
  4. doi request reprint Cinnamides as selective small-molecule inhibitors of a cellular model of breast cancer stem cells
    Andrew R Germain
    Chemical Biology Platform and Probe Development Center, Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA
    Bioorg Med Chem Lett 23:1834-8. 2013
  5. doi request reprint Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways
    Tamer T Onder
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, USA
    Cancer Res 68:3645-54. 2008
  6. ncbi request reprint Systemic stromal effects of estrogen promote the growth of estrogen receptor-negative cancers
    Piyush B Gupta
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA
    Cancer Res 67:2062-71. 2007
  7. pmc A physical and regulatory map of host-influenza interactions reveals pathways in H1N1 infection
    Sagi D Shapira
    Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA
    Cell 139:1255-67. 2009
  8. doi request reprint Cancer stem cells: mirage or reality?
    Piyush B Gupta
    Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts, USA
    Nat Med 15:1010-2. 2009
  9. doi request reprint Identification of a selective small molecule inhibitor of breast cancer stem cells
    Andrew R Germain
    Chemical Biology Platform and Probe Development Center, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
    Bioorg Med Chem Lett 22:3571-4. 2012
  10. ncbi request reprint Contributions of estrogen to ER-negative breast tumor growth
    Piyush B Gupta
    Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA
    J Steroid Biochem Mol Biol 102:71-8. 2006

Collaborators

Detail Information

Publications10

  1. pmc Cell-state transitions regulated by SLUG are critical for tissue regeneration and tumor initiation
    Sarah Phillips
    Department of Developmental, Molecular and Chemical Biology, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA Molecular Oncology Research Institute, Tufts Medical Center, 800 Washington Street, Boston, MA 02111, USA
    Stem Cell Reports 2:633-47. 2014
    ..Together, these results demonstrate that SLUG plays a dual role in repressing luminal epithelial differentiation while unlocking stem cell transitions necessary for tumorigenesis. ..
  2. doi request reprint Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells
    Piyush B Gupta
    Broad Institute, Cambridge, MA 02142, USA
    Cell 146:633-44. 2011
    ..These findings contribute to our understanding of cancer heterogeneity and reveal how stochasticity in single-cell behaviors promotes phenotypic equilibrium in populations of cancer cells...
  3. doi request reprint Identification of selective inhibitors of cancer stem cells by high-throughput screening
    Piyush B Gupta
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 138:645-59. 2009
    ..This study demonstrates the ability to identify agents with specific toxicity for epithelial CSCs...
  4. doi request reprint Cinnamides as selective small-molecule inhibitors of a cellular model of breast cancer stem cells
    Andrew R Germain
    Chemical Biology Platform and Probe Development Center, Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA
    Bioorg Med Chem Lett 23:1834-8. 2013
    ..Herein, we report structure-activity relationships of this class of cinnamides for selective lethality towards CSC-enriched populations...
  5. doi request reprint Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways
    Tamer T Onder
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, USA
    Cancer Res 68:3645-54. 2008
    ..These findings indicate that E-cadherin loss in tumors contributes to metastatic dissemination by inducing wide-ranging transcriptional and functional changes...
  6. ncbi request reprint Systemic stromal effects of estrogen promote the growth of estrogen receptor-negative cancers
    Piyush B Gupta
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA
    Cancer Res 67:2062-71. 2007
    ..Furthermore, bone marrow cells from estrogen-treated mice were sufficient to promote tumor growth. These results reveal a novel mechanism by which estrogens promote the growth of ER-negative cancers...
  7. pmc A physical and regulatory map of host-influenza interactions reveals pathways in H1N1 infection
    Sagi D Shapira
    Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA
    Cell 139:1255-67. 2009
    ..This multilayered approach provides a comprehensive and unbiased physical and regulatory model of influenza-host interactions and demonstrates a general strategy for uncovering complex host-pathogen relationships...
  8. doi request reprint Cancer stem cells: mirage or reality?
    Piyush B Gupta
    Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts, USA
    Nat Med 15:1010-2. 2009
    ..If present, such plasticity would have major implications for the CSC model and for future therapeutic approaches...
  9. doi request reprint Identification of a selective small molecule inhibitor of breast cancer stem cells
    Andrew R Germain
    Chemical Biology Platform and Probe Development Center, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
    Bioorg Med Chem Lett 22:3571-4. 2012
    ....
  10. ncbi request reprint Contributions of estrogen to ER-negative breast tumor growth
    Piyush B Gupta
    Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA
    J Steroid Biochem Mol Biol 102:71-8. 2006
    ..Taken together, these data suggest that estrogen may promote the growth of ER-negative cancers by acting on cells distinct from the cancer cells to stimulate angiogenesis...