Piyush B Gupta

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. doi request reprint Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells
    Piyush B Gupta
    Broad Institute, Cambridge, MA 02142, USA
    Cell 146:633-44. 2011
  2. doi request reprint Identification of selective inhibitors of cancer stem cells by high-throughput screening
    Piyush B Gupta
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 138:645-59. 2009
  3. doi request reprint Cinnamides as selective small-molecule inhibitors of a cellular model of breast cancer stem cells
    Andrew R Germain
    Chemical Biology Platform and Probe Development Center, Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA
    Bioorg Med Chem Lett 23:1834-8. 2013
  4. doi request reprint Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways
    Tamer T Onder
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, USA
    Cancer Res 68:3645-54. 2008
  5. ncbi request reprint Systemic stromal effects of estrogen promote the growth of estrogen receptor-negative cancers
    Piyush B Gupta
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA
    Cancer Res 67:2062-71. 2007
  6. doi request reprint Cancer stem cells: mirage or reality?
    Piyush B Gupta
    Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts, USA
    Nat Med 15:1010-2. 2009
  7. pmc A physical and regulatory map of host-influenza interactions reveals pathways in H1N1 infection
    Sagi D Shapira
    Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA
    Cell 139:1255-67. 2009
  8. doi request reprint Identification of a selective small molecule inhibitor of breast cancer stem cells
    Andrew R Germain
    Chemical Biology Platform and Probe Development Center, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
    Bioorg Med Chem Lett 22:3571-4. 2012
  9. ncbi request reprint Contributions of estrogen to ER-negative breast tumor growth
    Piyush B Gupta
    Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA
    J Steroid Biochem Mol Biol 102:71-8. 2006

Collaborators

Detail Information

Publications9

  1. doi request reprint Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells
    Piyush B Gupta
    Broad Institute, Cambridge, MA 02142, USA
    Cell 146:633-44. 2011
    ..These findings contribute to our understanding of cancer heterogeneity and reveal how stochasticity in single-cell behaviors promotes phenotypic equilibrium in populations of cancer cells...
  2. doi request reprint Identification of selective inhibitors of cancer stem cells by high-throughput screening
    Piyush B Gupta
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 138:645-59. 2009
    ..This study demonstrates the ability to identify agents with specific toxicity for epithelial CSCs...
  3. doi request reprint Cinnamides as selective small-molecule inhibitors of a cellular model of breast cancer stem cells
    Andrew R Germain
    Chemical Biology Platform and Probe Development Center, Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA
    Bioorg Med Chem Lett 23:1834-8. 2013
    ..Herein, we report structure-activity relationships of this class of cinnamides for selective lethality towards CSC-enriched populations...
  4. doi request reprint Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways
    Tamer T Onder
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, USA
    Cancer Res 68:3645-54. 2008
    ..These findings indicate that E-cadherin loss in tumors contributes to metastatic dissemination by inducing wide-ranging transcriptional and functional changes...
  5. ncbi request reprint Systemic stromal effects of estrogen promote the growth of estrogen receptor-negative cancers
    Piyush B Gupta
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA
    Cancer Res 67:2062-71. 2007
    ..Furthermore, bone marrow cells from estrogen-treated mice were sufficient to promote tumor growth. These results reveal a novel mechanism by which estrogens promote the growth of ER-negative cancers...
  6. doi request reprint Cancer stem cells: mirage or reality?
    Piyush B Gupta
    Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts, USA
    Nat Med 15:1010-2. 2009
    ..If present, such plasticity would have major implications for the CSC model and for future therapeutic approaches...
  7. pmc A physical and regulatory map of host-influenza interactions reveals pathways in H1N1 infection
    Sagi D Shapira
    Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA
    Cell 139:1255-67. 2009
    ..This multilayered approach provides a comprehensive and unbiased physical and regulatory model of influenza-host interactions and demonstrates a general strategy for uncovering complex host-pathogen relationships...
  8. doi request reprint Identification of a selective small molecule inhibitor of breast cancer stem cells
    Andrew R Germain
    Chemical Biology Platform and Probe Development Center, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
    Bioorg Med Chem Lett 22:3571-4. 2012
    ....
  9. ncbi request reprint Contributions of estrogen to ER-negative breast tumor growth
    Piyush B Gupta
    Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA
    J Steroid Biochem Mol Biol 102:71-8. 2006
    ..Taken together, these data suggest that estrogen may promote the growth of ER-negative cancers by acting on cells distinct from the cancer cells to stimulate angiogenesis...