Shuzhen Guo

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc Amelioration of inflammation and cytotoxicity by dipyridamole in brain endothelial cells
    Shuzhen Guo
    Neuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Mass, USA
    Cerebrovasc Dis 30:290-6. 2010
  2. pmc Vascular neuroprotection via TrkB- and Akt-dependent cell survival signaling
    Shuzhen Guo
    Neuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    J Neurochem 123:58-64. 2012
  3. pmc The vasculome of the mouse brain
    Shuzhen Guo
    Neuroprotection Research Laboratory, Departments of Radiology and Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    PLoS ONE 7:e52665. 2012
  4. pmc Crosstalk between oligodendrocytes and cerebral endothelium contributes to vascular remodeling after white matter injury
    Loc Duyen D Pham
    Neuroprotection Research Laboratory, Departments of Radiology and Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Glia 60:875-81. 2012
  5. pmc Lithium upregulates vascular endothelial growth factor in brain endothelial cells and astrocytes
    Shuzhen Guo
    Department of Radiology and Neurology, Neuroprotection Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Stroke 40:652-5. 2009
  6. pmc Cerebral endothelial derived vascular endothelial growth factor promotes the migration but not the proliferation of oligodendrocyte precursor cells in vitro
    Kazuhide Hayakawa
    Neuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    Neurosci Lett 513:42-6. 2012
  7. pmc Vascular endothelial growth factor regulates the migration of oligodendrocyte precursor cells
    Kazuhide Hayakawa
    Neuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Neurosci 31:10666-70. 2011
  8. pmc Neuroprotective effects of overexpressing tissue inhibitor of metalloproteinase TIMP-1
    Emiri Tejima
    Program in Neuroscience, Harvard Medical School, Charlestown, Massachusetts, USA
    J Neurotrauma 26:1935-41. 2009
  9. pmc Pro-angiogenic effects of resveratrol in brain endothelial cells: nitric oxide-mediated regulation of vascular endothelial growth factor and metalloproteinases
    Fabrício Simão
    Departments of Radiology and Neurology, Neuroprotection Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    J Cereb Blood Flow Metab 32:884-95. 2012
  10. pmc Effects of neuroglobin overexpression on mitochondrial function and oxidative stress following hypoxia/reoxygenation in cultured neurons
    Jianxiang Liu
    Neuroprotection Research Laboratory, Department of Neurology, Massachusetts General Hospital, and Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02129, USA
    J Neurosci Res 87:164-70. 2009

Collaborators

Detail Information

Publications29

  1. pmc Amelioration of inflammation and cytotoxicity by dipyridamole in brain endothelial cells
    Shuzhen Guo
    Neuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Mass, USA
    Cerebrovasc Dis 30:290-6. 2010
    ..In this experimental cellular study, we asked whether dipyridamole can ameliorate brain endothelial injury after exposure to inflammatory and metabolic insults...
  2. pmc Vascular neuroprotection via TrkB- and Akt-dependent cell survival signaling
    Shuzhen Guo
    Neuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    J Neurochem 123:58-64. 2012
    ..Further investigation of these mechanisms may reveal new approaches for augmenting endogenous vascular neuroprotection in stroke, brain injury, and neurodegeneration...
  3. pmc The vasculome of the mouse brain
    Shuzhen Guo
    Neuroprotection Research Laboratory, Departments of Radiology and Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    PLoS ONE 7:e52665. 2012
    ..Mapping and dissecting the vasculome of the brain in health and disease may provide a novel database for investigating disease mechanisms, assessing therapeutic targets and exploring new biomarkers for the CNS...
  4. pmc Crosstalk between oligodendrocytes and cerebral endothelium contributes to vascular remodeling after white matter injury
    Loc Duyen D Pham
    Neuroprotection Research Laboratory, Departments of Radiology and Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Glia 60:875-81. 2012
    ..In gray matter, a neurovascular niche promotes cortical recovery after brain injury. Our study suggests that an analogous oligovascular niche may mediate recovery in white matter...
  5. pmc Lithium upregulates vascular endothelial growth factor in brain endothelial cells and astrocytes
    Shuzhen Guo
    Department of Radiology and Neurology, Neuroprotection Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Stroke 40:652-5. 2009
    ..We tested the hypothesis that lithium can promote the expression of growth factors in brain endothelial cells and astrocytes...
  6. pmc Cerebral endothelial derived vascular endothelial growth factor promotes the migration but not the proliferation of oligodendrocyte precursor cells in vitro
    Kazuhide Hayakawa
    Neuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    Neurosci Lett 513:42-6. 2012
    ..This phenomenon may be important for white matter homeostasis...
  7. pmc Vascular endothelial growth factor regulates the migration of oligodendrocyte precursor cells
    Kazuhide Hayakawa
    Neuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Neurosci 31:10666-70. 2011
    ..Our findings demonstrate that VEGF-A can induce OPC migration via an ROS- and FAK-dependent mechanism, and suggest a novel role for VEGF-A in white-matter maintenance and homeostasis...
  8. pmc Neuroprotective effects of overexpressing tissue inhibitor of metalloproteinase TIMP-1
    Emiri Tejima
    Program in Neuroscience, Harvard Medical School, Charlestown, Massachusetts, USA
    J Neurotrauma 26:1935-41. 2009
    ..Taken together, these cell culture and in vivo data provide initial proof-of-principle that TIMP-1 is neuroprotective against traumatic and ischemic brain injury in mice...
  9. pmc Pro-angiogenic effects of resveratrol in brain endothelial cells: nitric oxide-mediated regulation of vascular endothelial growth factor and metalloproteinases
    Fabrício Simão
    Departments of Radiology and Neurology, Neuroprotection Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    J Cereb Blood Flow Metab 32:884-95. 2012
    ..These findings provide a mechanistic basis for the potential use of resveratrol as a candidate therapy to promote angiogenesis and neurovascular recovery after stroke...
  10. pmc Effects of neuroglobin overexpression on mitochondrial function and oxidative stress following hypoxia/reoxygenation in cultured neurons
    Jianxiang Liu
    Neuroprotection Research Laboratory, Department of Neurology, Massachusetts General Hospital, and Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02129, USA
    J Neurosci Res 87:164-70. 2009
    ..Taken together, these data suggest that Ngb is neuroprotective against hypoxia, in part by improving mitochondria function and decreasing oxidative stress...
  11. pmc Cerebrovascular degradation of TRKB by MMP9 in the diabetic brain
    Deepti Navaratna
    Neuroprotection Research Laboratory, Departments of Radiology, Neurology, and Pediatrics, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Clin Invest 123:3373-7. 2013
    ..Our findings demonstrate that neuronal TRKB trophic function is ablated by MMP9-mediated degradation in the diabetic brain, disrupting cerebrovascular trophic coupling and leaving the brain vulnerable to injury. ..
  12. pmc Neuregulin-1 signaling in brain endothelial cells
    Josephine Lok
    Neuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129, USA
    J Cereb Blood Flow Metab 29:39-43. 2009
    ..These data suggest that NRG1 signaling is functional and cytoprotective in BMECs...
  13. pmc γ-glutamylcysteine ethyl ester protects cerebral endothelial cells during injury and decreases blood-brain barrier permeability after experimental brain trauma
    Josephine Lok
    Neuroprotection Research Laboratory, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Neurochem 118:248-55. 2011
    ..These data suggest that the beneficial effects of GCEE on brain endothelial cells and microvessels may contribute to its potential efficacy as a neuroprotective agent in traumatic brain injury...
  14. pmc Cellular mechanisms of neurovascular damage and repair after stroke
    Ken Arai
    The Neuroprotection Research Laboratory, Departments of Radiology and Neurology, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts, USA
    J Child Neurol 26:1193-8. 2011
    ..Because plasticity is a signature feature of the young and developing brain, these concepts may have special relevance to how the pediatric brain responds after stroke...
  15. pmc Effects of tissue plasminogen activator and annexin A2 combination therapy on long-term neurological outcomes of rat focal embolic stroke
    Xiaoshu Wang
    From the Department of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China Xiaoshu Wang, Z L and Neuroprotection Research Laboratory, Departments of Neurology and Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA Xiaoshu Wang, X F, Z Y, Z L, J Z, E M, S G, E H L, Xiaoying Wang
    Stroke 45:619-22. 2014
    ..Here, we ask whether tPA-plus-rA2 combination therapy can lead to sustained long-term neurological improvements as well...
  16. pmc Assays to examine endothelial cell migration, tube formation, and gene expression profiles
    Shuzhen Guo
    Neuroprotection Research Laboratory, Department of Radiology and Neurology, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA
    Methods Mol Biol 1135:393-402. 2014
    ..Protocols for these procedures will be described here. ..
  17. pmc Neuroprotection via matrix-trophic coupling between cerebral endothelial cells and neurons
    Shuzhen Guo
    Neuroprotection Research Laboratory, Departments of Neurology and Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129
    Proc Natl Acad Sci U S A 105:7582-7. 2008
    ..Targeting these signals of matrix and trophic coupling between endothelium and neurons may provide new therapeutic opportunities for stroke and other CNS disorders...
  18. pmc Interleukin-1beta augments angiogenic responses of murine endothelial progenitor cells in vitro
    Anna Rosell
    Neuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Cereb Blood Flow Metab 29:933-43. 2009
    ..Further studies are warranted to assess how interactions between proinflammatory environments and EPC responses may be leveraged to enhance therapeutic angiogenesis...
  19. pmc Neurovascular matrix metalloproteinases and the blood-brain barrier
    Ji Hae Seo
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Curr Pharm Des 18:3645-8. 2012
    ..Because BBB perturbations may also occur in neurodegeneration, MMPs and associated neurovascular unit mechanisms may also be potential targets in a broader range of CNS disorders...
  20. pmc Proteomic temporal profile of human brain endothelium after oxidative stress
    MingMing Ning
    Clinical Proteomics Research Center, Massachusetts General Hospital, Harvard Medial School, Boston, MA, USA
    Stroke 42:37-43. 2011
    ..because brain endothelial cells exist at the neurovascular interface, they may serve as cellular reporters of brain dysfunction by releasing biomarkers into the circulation...
  21. pmc Fingolimod provides long-term protection in rodent models of cerebral ischemia
    Ying Wei
    Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA
    Ann Neurol 69:119-29. 2011
    ....
  22. pmc Dysfunctional cell-cell signaling in the neurovascular unit as a paradigm for central nervous system disease
    Shuzhen Guo
    Neuroprotection Research Laboratory, MGH East 149 2401, 13th Street, Charlestown, MA 02129, USA
    Stroke 40:S4-7. 2009
    ..This minireview surveys recent data that support this basic idea, with examples drawn from experimental models broadly relevant to stroke and neurodegeneration...
  23. pmc Genetic analysis of the role of tumor necrosis factor receptors in functional outcome after traumatic brain injury in mice
    Jinsheng Yang
    Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Neurotrauma 27:1037-46. 2010
    ..Further studies are needed to determine whether direct or indirect effects of TNFR1 deletion in TNFR2/Fas KO mice mediate improved functional outcome in TNFR1/TNFR2/Fas KO mice after CCI...
  24. pmc Delivering minocycline into brain endothelial cells with liposome-based technology
    Changhong Xing
    Departments of Radiology and Neurology, Neuroprotection Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA
    J Cereb Blood Flow Metab 32:983-8. 2012
    ..This study provides proof-of-concept that liposomes may be used to deliver lower levels of minocycline for targeting MMPs in cerebral endothelium...
  25. pmc Studying extracellular signaling utilizing a glycoproteomic approach: lectin blot surveys, a first and important step
    Jing Cao
    Neuroprotection Research Laboratory, Massachussetts General Hospital and Harvard Medical School, Boston, MA, USA
    Methods Mol Biol 1013:227-33. 2013
    ..Here, we will use patient plasma samples post hypothermic therapy-an extremely complex medium-as a tool to describe in detail the technique of lectin blotting for proteomic analysis...
  26. ncbi request reprint Cell-cell signaling in the neurovascular unit
    Josephine Lok
    Neuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital, MGH East 149 2401, Charlestown, MA 02129, USA
    Neurochem Res 32:2032-45. 2007
    ....
  27. doi request reprint Beyond NMDA and AMPA glutamate receptors: emerging mechanisms for ionic imbalance and cell death in stroke
    Elaine Besancon
    Neuroprotection Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
    Trends Pharmacol Sci 29:268-75. 2008
    ..Further in vivo validation of these pathways could ultimately lead us to new therapeutic targets for stroke, trauma and neurodegeneration...
  28. pmc Mechanisms and targets for angiogenic therapy after stroke
    Deepti Navaratna
    Departments of Radiology and Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, USA
    Cell Adh Migr 3:216-23. 2009
    ..A better understanding of the molecular interplay between all these complex pathways may lead to novel therapeutic avenues for tackling this difficult disease...
  29. ncbi request reprint RTEF-1 attenuates blood glucose levels by regulating insulin-like growth factor binding protein-1 in the endothelium
    Angela F Messmer-Blust
    Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Circ Res 111:991-1001. 2012
    ..Related transcriptional enhancer factor-1 (RTEF-1) plays an important role in endothelial cell function by regulating angiogenesis; however, the mechanism underlying the role of RTEF-1 in the endothelium in vivo is not well defined...