Genomes and Genes
Alexander R Guimaraes
Affiliation: Massachusetts General Hospital
- MRI with magnetic nanoparticles monitors downstream anti-angiogenic effects of mTOR inhibitionAlexander R Guimaraes
Center for Molecular Imaging Research, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA
Mol Imaging Biol 13:314-20. 2011..To study the effect of mammalian target of rapamycin (mTOR) inhibition on angiogenesis with magnetic resonance imaging (MRI) using magnetic iron oxide nanoparticles (MNP)...
- Pilot study evaluating use of lymphotrophic nanoparticle-enhanced magnetic resonance imaging for assessing lymph nodes in renal cell cancerAlexander R Guimaraes
Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Urology 71:708-12. 2008..To assess lymphotrophic nanoparticle-enhanced magnetic resonance imaging (LNMRI) in identifying malignant nodal involvement in patients with renal neoplasms...
- Lymphotropic nanoparticle-enhanced magnetic resonance imaging (LNMRI) identifies occult lymph node metastases in prostate cancer patients prior to salvage radiation therapyRobert W Ross
Center for Molecular Imaging Research, Massachusetts General Hospital, Boston, MA 02114, USA
Clin Imaging 33:301-5. 2009..Six (23%) of the 26 patients, previously believed to be node negative, tested lymph node positive by LNMRI. A total of nine positive lymph nodes were identified in these six patients, none of which were enlarged based on size criteria...
- Utility of a new bolus-injectable nanoparticle for clinical cancer stagingMukesh Harisinghani
Center for Molecular Imaging Research, Massachusetts General Hospital, Boston, MA 02129 2060, USA
Neoplasia 9:1160-5. 2007..In this study, we report on the use of a new, bolus-injectable, carboxymethyl dextran-based magnetic nanoparticle (MNP), ferumoxytol, to improve detection in loco-regional lymph nodes by magnetic resonance imaging (MRI)...
- Magnetic resonance imaging monitors physiological changes with antihedgehog therapy in pancreatic adenocarcinoma xenograft modelAlexander R Guimaraes
Department of Radiology, Center for Molecular Imaging Research, Massachusetts General Hospital, Charlestown, MA, USA
Pancreas 37:440-4. 2008..We tested whether magnetic resonance imaging measures of vascular volume fraction (VVF) using magnetic iron oxide nanoparticles are sensitive to the antiangiogenic effect of targeted Shh therapies in a PDAC xenograft model...
- Treatment of deep intramuscular and musculoskeletal abscess: experience with 99 CT-guided percutaneous catheter drainage proceduresCarmel G Cronin
Department of Abdominal Imaging and Interventional Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, 02214, USA
AJR Am J Roentgenol 196:1182-8. 2011....
- Noninvasive imaging of pancreatic islet inflammation in type 1A diabetes patientsJason L Gaglia
Department of Pathology, Harvard Medical School, Boston, Massachusetts, USA
J Clin Invest 121:442-5. 2011..The observation that MNPs accumulate in the pancreas of T1D patients opens the door to exploiting this noninvasive imaging method to follow T1D progression and monitoring the ability of immunomodulatory agents to clear insulitis...
- Molecular MR imaging of liver fibrosis: a feasibility study using rat and mouse modelsMiloslav Polásek
A A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 149 Thirteenth St, Suite 2301, Charlestown, MA 02129, United States
J Hepatol 57:549-55. 2012..We hypothesize that molecular magnetic resonance imaging (MRI) with a probe targeted to type I collagen could provide a direct and non-invasive method of fibrosis assessment...
- The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolismCarlos Sebastian
The Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA 02114, USA
Cell 151:1185-99. 2012..Our studies reveal SIRT6 to be a potent tumor suppressor acting to suppress cancer metabolism...
- State-of-the-art PET/CT of the pancreas: current role and emerging indicationsDushyant V Sahani
Department of Radiology, Division of Abdominal Imaging and Interventional Radiology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St, White 270, Boston, MA 02114, USA
Radiographics 32:1133-58; discussion 1158-60. 2012..Novel radiolabeled molecules, such as sigma-receptor ligands and 18F-3'-fluoro-3'-deoxy-l-thymidine (FLT), may play an even greater role in distinguishing tumor recurrence from postoperative fibrosis or inflammation...
- Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolismHaoqiang Ying
Belfer Institute for Applied Cancer Science, Dana Farber Cancer Institute, Boston, MA 02215, USA Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02215, USA
Cell 149:656-70. 2012..Together, this work provides in vivo mechanistic insights into how oncogenic Kras promotes metabolic reprogramming in native tumors and illuminates potential metabolic targets that can be exploited for therapeutic benefit in PDAC...
- Imaging primary lung cancers in mice to study radiation biologyDavid G Kirsch
The David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA
Int J Radiat Oncol Biol Phys 76:973-7. 2010..To image a genetically engineered mouse model of non-small-cell lung cancer with micro-computed tomography (micro-CT) to measure tumor response to radiation therapy...
- The phosphoinositide 3-kinase regulatory subunit p85alpha can exert tumor suppressor properties through negative regulation of growth factor signalingCullen M Taniguchi
Joslin Diabetes Center and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02215, USA
Cancer Res 70:5305-15. 2010..Together, these results substantiate the concept that the p85 subunit of PI3K has a tumor-suppressive role in the liver and possibly other tissues...