Alexander R Guimaraes

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. doi request reprint Pilot study evaluating use of lymphotrophic nanoparticle-enhanced magnetic resonance imaging for assessing lymph nodes in renal cell cancer
    Alexander R Guimaraes
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Urology 71:708-12. 2008
  2. doi request reprint MRI with magnetic nanoparticles monitors downstream anti-angiogenic effects of mTOR inhibition
    Alexander R Guimaraes
    Center for Molecular Imaging Research, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA
    Mol Imaging Biol 13:314-20. 2011
  3. ncbi request reprint Lymphotropic nanoparticle-enhanced magnetic resonance imaging (LNMRI) identifies occult lymph node metastases in prostate cancer patients prior to salvage radiation therapy
    Robert W Ross
    Center for Molecular Imaging Research, Massachusetts General Hospital, Boston, MA 02114, USA
    Clin Imaging 33:301-5. 2009
  4. doi request reprint Clinical impact of PET/MR imaging in patients with cancer undergoing same-day PET/CT: initial experience in 134 patients--a hypothesis-generating exploratory study
    Onofrio A Catalano
    From the Departments of Radiology O A C and Nuclear Medicine E N, A s, SDN Istituto Ricerca Diagnostica Nucleare, Via Gianturco 113, Naples 80143, Italy Department of Radiology, Athinoula A Martinos Center for Biomedical Imaging B R R, A R G, M G V, and Biostatistics Center M G V, Massachusetts General Hospital, Harvard University Medical School, Charlestown, Mass Department of Radiology, Massachusetts General Hospital, Harvard University Medical School, Boston, Mass D V S, P F H and Department of Radiology, University of Naples Federico II, Naples, Italy M S
    Radiology 269:857-69. 2013
  5. pmc Utility of a new bolus-injectable nanoparticle for clinical cancer staging
    Mukesh Harisinghani
    Center for Molecular Imaging Research, Massachusetts General Hospital, Boston, MA 02129 2060, USA
    Neoplasia 9:1160-5. 2007
  6. pmc Magnetic resonance imaging monitors physiological changes with antihedgehog therapy in pancreatic adenocarcinoma xenograft model
    Alexander R Guimaraes
    Department of Radiology, Center for Molecular Imaging Research, Massachusetts General Hospital, Charlestown, MA, USA
    Pancreas 37:440-4. 2008
  7. doi request reprint Treatment of deep intramuscular and musculoskeletal abscess: experience with 99 CT-guided percutaneous catheter drainage procedures
    Carmel G Cronin
    Department of Abdominal Imaging and Interventional Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, 02214, USA
    AJR Am J Roentgenol 196:1182-8. 2011
  8. pmc Noninvasive imaging of pancreatic islet inflammation in type 1A diabetes patients
    Jason L Gaglia
    Department of Pathology, Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 121:442-5. 2011
  9. ncbi request reprint Oncologic applications of dual-energy CT in the abdomen
    Mukta D Agrawal
    From the Department of Abdominal and Interventional Radiology, Massachusetts General Hospital, 55 Fruit St, White Building, Room 270, Boston, MA 02114 2696
    Radiographics 34:589-612. 2014
  10. pmc FOLFIRINOX in locally advanced pancreatic cancer: the Massachusetts General Hospital Cancer Center experience
    Jason E Faris
    Department of Hematology Oncology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Oncologist 18:543-8. 2013

Collaborators

Detail Information

Publications20

  1. doi request reprint Pilot study evaluating use of lymphotrophic nanoparticle-enhanced magnetic resonance imaging for assessing lymph nodes in renal cell cancer
    Alexander R Guimaraes
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Urology 71:708-12. 2008
    ..To assess lymphotrophic nanoparticle-enhanced magnetic resonance imaging (LNMRI) in identifying malignant nodal involvement in patients with renal neoplasms...
  2. doi request reprint MRI with magnetic nanoparticles monitors downstream anti-angiogenic effects of mTOR inhibition
    Alexander R Guimaraes
    Center for Molecular Imaging Research, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA
    Mol Imaging Biol 13:314-20. 2011
    ..To study the effect of mammalian target of rapamycin (mTOR) inhibition on angiogenesis with magnetic resonance imaging (MRI) using magnetic iron oxide nanoparticles (MNP)...
  3. ncbi request reprint Lymphotropic nanoparticle-enhanced magnetic resonance imaging (LNMRI) identifies occult lymph node metastases in prostate cancer patients prior to salvage radiation therapy
    Robert W Ross
    Center for Molecular Imaging Research, Massachusetts General Hospital, Boston, MA 02114, USA
    Clin Imaging 33:301-5. 2009
    ..Six (23%) of the 26 patients, previously believed to be node negative, tested lymph node positive by LNMRI. A total of nine positive lymph nodes were identified in these six patients, none of which were enlarged based on size criteria...
  4. doi request reprint Clinical impact of PET/MR imaging in patients with cancer undergoing same-day PET/CT: initial experience in 134 patients--a hypothesis-generating exploratory study
    Onofrio A Catalano
    From the Departments of Radiology O A C and Nuclear Medicine E N, A s, SDN Istituto Ricerca Diagnostica Nucleare, Via Gianturco 113, Naples 80143, Italy Department of Radiology, Athinoula A Martinos Center for Biomedical Imaging B R R, A R G, M G V, and Biostatistics Center M G V, Massachusetts General Hospital, Harvard University Medical School, Charlestown, Mass Department of Radiology, Massachusetts General Hospital, Harvard University Medical School, Boston, Mass D V S, P F H and Department of Radiology, University of Naples Federico II, Naples, Italy M S
    Radiology 269:857-69. 2013
    ..To compare the clinical impact of combined positron emission tomography (PET) and magnetic resonance (MR) imaging to that of combined PET and computed tomography (CT) performed on the same day in patients with cancer...
  5. pmc Utility of a new bolus-injectable nanoparticle for clinical cancer staging
    Mukesh Harisinghani
    Center for Molecular Imaging Research, Massachusetts General Hospital, Boston, MA 02129 2060, USA
    Neoplasia 9:1160-5. 2007
    ..In this study, we report on the use of a new, bolus-injectable, carboxymethyl dextran-based magnetic nanoparticle (MNP), ferumoxytol, to improve detection in loco-regional lymph nodes by magnetic resonance imaging (MRI)...
  6. pmc Magnetic resonance imaging monitors physiological changes with antihedgehog therapy in pancreatic adenocarcinoma xenograft model
    Alexander R Guimaraes
    Department of Radiology, Center for Molecular Imaging Research, Massachusetts General Hospital, Charlestown, MA, USA
    Pancreas 37:440-4. 2008
    ..We tested whether magnetic resonance imaging measures of vascular volume fraction (VVF) using magnetic iron oxide nanoparticles are sensitive to the antiangiogenic effect of targeted Shh therapies in a PDAC xenograft model...
  7. doi request reprint Treatment of deep intramuscular and musculoskeletal abscess: experience with 99 CT-guided percutaneous catheter drainage procedures
    Carmel G Cronin
    Department of Abdominal Imaging and Interventional Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, 02214, USA
    AJR Am J Roentgenol 196:1182-8. 2011
    ....
  8. pmc Noninvasive imaging of pancreatic islet inflammation in type 1A diabetes patients
    Jason L Gaglia
    Department of Pathology, Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 121:442-5. 2011
    ..The observation that MNPs accumulate in the pancreas of T1D patients opens the door to exploiting this noninvasive imaging method to follow T1D progression and monitoring the ability of immunomodulatory agents to clear insulitis...
  9. ncbi request reprint Oncologic applications of dual-energy CT in the abdomen
    Mukta D Agrawal
    From the Department of Abdominal and Interventional Radiology, Massachusetts General Hospital, 55 Fruit St, White Building, Room 270, Boston, MA 02114 2696
    Radiographics 34:589-612. 2014
    ..Moreover, quantitative iodine mapping may serve as a surrogate biomarker for monitoring effects of the treatment. Dual-energy CT is an innovative imaging technique that enhances the capabilities of CT in evaluating oncology patients...
  10. pmc FOLFIRINOX in locally advanced pancreatic cancer: the Massachusetts General Hospital Cancer Center experience
    Jason E Faris
    Department of Hematology Oncology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Oncologist 18:543-8. 2013
    ..However, the recurrences following R0 resection in three of five patients and the toxicities observed with the use of this regimen raise important questions about how to best treat patients with LAPC...
  11. doi request reprint Gastric lymph node contouring atlas: A tool to aid in clinical target volume definition in 3-dimensional treatment planning for gastric cancer
    Jennifer Y Wo
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts Electronic address
    Pract Radiat Oncol 3:e11-9. 2013
    ..Conclusions: This report serves as a template for the delineation of gastric lymph node stations to aid in the definition of elective clinical target volumes to be used in conformal treatment planning. ..
  12. doi request reprint Feasibility study of in vivo MRI based dosimetric verification of proton end-of-range for liver cancer patients
    Yading Yuan
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Radiother Oncol 106:378-82. 2013
    ..To investigate the feasibility of using MRI to verify proton beam distal range for liver tumor treatment in a retrospective study...
  13. pmc PET and MR imaging: the odd couple or a match made in heaven?
    Ciprian Catana
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA
    J Nucl Med 54:815-24. 2013
    ..These examples range from studies that might immediately benefit from PET/MR to more advanced applications on which future development might have an even broader impact...
  14. pmc Effect of MRI acoustic noise on cerebral fludeoxyglucose uptake in simultaneous MR-PET imaging
    Daniel B Chonde
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA
    Invest Radiol 48:302-12. 2013
    ..Although particular attention was paid to the primary auditory cortex (PAC), a brain-wide analysis was also performed...
  15. pmc Molecular MR imaging of liver fibrosis: a feasibility study using rat and mouse models
    Miloslav Polásek
    A A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 149 Thirteenth St, Suite 2301, Charlestown, MA 02129, United States
    J Hepatol 57:549-55. 2012
    ..We hypothesize that molecular magnetic resonance imaging (MRI) with a probe targeted to type I collagen could provide a direct and non-invasive method of fibrosis assessment...
  16. pmc The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism
    Carlos Sebastian
    The Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA 02114, USA
    Cell 151:1185-99. 2012
    ..Our studies reveal SIRT6 to be a potent tumor suppressor acting to suppress cancer metabolism...
  17. doi request reprint State-of-the-art PET/CT of the pancreas: current role and emerging indications
    Dushyant V Sahani
    Department of Radiology, Division of Abdominal Imaging and Interventional Radiology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St, White 270, Boston, MA 02114, USA
    Radiographics 32:1133-58; discussion 1158-60. 2012
    ..Novel radiolabeled molecules, such as sigma-receptor ligands and 18F-3'-fluoro-3'-deoxy-l-thymidine (FLT), may play an even greater role in distinguishing tumor recurrence from postoperative fibrosis or inflammation...
  18. pmc Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism
    Haoqiang Ying
    Belfer Institute for Applied Cancer Science, Dana Farber Cancer Institute, Boston, MA 02215, USA Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02215, USA
    Cell 149:656-70. 2012
    ..Together, this work provides in vivo mechanistic insights into how oncogenic Kras promotes metabolic reprogramming in native tumors and illuminates potential metabolic targets that can be exploited for therapeutic benefit in PDAC...
  19. pmc Imaging primary lung cancers in mice to study radiation biology
    David G Kirsch
    The David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA
    Int J Radiat Oncol Biol Phys 76:973-7. 2010
    ..To image a genetically engineered mouse model of non-small-cell lung cancer with micro-computed tomography (micro-CT) to measure tumor response to radiation therapy...
  20. pmc The phosphoinositide 3-kinase regulatory subunit p85alpha can exert tumor suppressor properties through negative regulation of growth factor signaling
    Cullen M Taniguchi
    Joslin Diabetes Center and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02215, USA
    Cancer Res 70:5305-15. 2010
    ..Together, these results substantiate the concept that the p85 subunit of PI3K has a tumor-suppressive role in the liver and possibly other tissues...