Alan Grodzinsky

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. pmc Synoviocytes protect cartilage from the effects of injury in vitro
    Christina M Lee
    Orthopaedic Research Center, Department of Clinical Sciences, College of Veterinary Medicine, Colorado State University, 300 West Drake Rd, Fort Collins, Colorado CO 80523, USA
    BMC Musculoskelet Disord 14:54. 2013
  2. pmc Effects of short-term glucocorticoid treatment on changes in cartilage matrix degradation and chondrocyte gene expression induced by mechanical injury and inflammatory cytokines
    Yihong C S Lu
    Department of Biological Engineering, MIT, 500 Technology Square NE47 377, Cambridge, MA 02139, USA
    Arthritis Res Ther 13:R142. 2011
  3. pmc A mathematical model for targeting chemicals to tissues by exploiting complex degradation
    Bruce S Gardiner
    School of Computer Science and Software Engineering, The University of Western Australia, WA, 6009, Australia
    Biol Direct 6:46. 2011
  4. ncbi Cartilage tissue remodeling in response to mechanical forces
    A J Grodzinsky
    Department of Electrical Engineering and Computer Science, Department of Mechanical Engineering, Division of Bioengineering and Environmental Health, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Annu Rev Biomed Eng 2:691-713. 2000
  5. pmc High-bandwidth AFM-based rheology reveals that cartilage is most sensitive to high loading rates at early stages of impairment
    Hadi Tavakoli Nia
    Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Biophys J 104:1529-37. 2013
  6. pmc Poroelasticity of cartilage at the nanoscale
    Hadi Tavakoli Nia
    Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Biophys J 101:2304-13. 2011
  7. ncbi Mechanical injury of cartilage explants causes specific time-dependent changes in chondrocyte gene expression
    Jennifer H Lee
    Massachusetts Institute of Technology, Cambridge, 02139, USA
    Arthritis Rheum 52:2386-95. 2005
  8. ncbi Mechanical compression of cartilage explants induces multiple time-dependent gene expression patterns and involves intracellular calcium and cyclic AMP
    Jonathan B Fitzgerald
    Biological Engineering Division, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    J Biol Chem 279:19502-11. 2004
  9. ncbi Transcranial direct current stimulation: a computer-based human model study
    Tim Wagner
    Center for Non Invasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Neuroimage 35:1113-24. 2007
  10. ncbi Transcranial magnetic stimulation and stroke: a computer-based human model study
    Tim Wagner
    Center for Non Invasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Neuroimage 30:857-70. 2006

Research Grants

Collaborators

Detail Information

Publications55

  1. pmc Synoviocytes protect cartilage from the effects of injury in vitro
    Christina M Lee
    Orthopaedic Research Center, Department of Clinical Sciences, College of Veterinary Medicine, Colorado State University, 300 West Drake Rd, Fort Collins, Colorado CO 80523, USA
    BMC Musculoskelet Disord 14:54. 2013
    ..Although much research of injury induced OA has focused on cartilage, OA is a disease that affects the whole joint organ...
  2. pmc Effects of short-term glucocorticoid treatment on changes in cartilage matrix degradation and chondrocyte gene expression induced by mechanical injury and inflammatory cytokines
    Yihong C S Lu
    Department of Biological Engineering, MIT, 500 Technology Square NE47 377, Cambridge, MA 02139, USA
    Arthritis Res Ther 13:R142. 2011
    ....
  3. pmc A mathematical model for targeting chemicals to tissues by exploiting complex degradation
    Bruce S Gardiner
    School of Computer Science and Software Engineering, The University of Western Australia, WA, 6009, Australia
    Biol Direct 6:46. 2011
    ..In addition, the complex, c, can be broken down by a process (e.g. an enzyme in the tissue) that results in the release of the chemical, a, which is then free to exert its biological action...
  4. ncbi Cartilage tissue remodeling in response to mechanical forces
    A J Grodzinsky
    Department of Electrical Engineering and Computer Science, Department of Mechanical Engineering, Division of Bioengineering and Environmental Health, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Annu Rev Biomed Eng 2:691-713. 2000
    ....
  5. pmc High-bandwidth AFM-based rheology reveals that cartilage is most sensitive to high loading rates at early stages of impairment
    Hadi Tavakoli Nia
    Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Biophys J 104:1529-37. 2013
    ..Thus, over the wide frequency range of joint motion during daily activities, hydraulic permeability appears the most sensitive marker of early tissue degradation...
  6. pmc Poroelasticity of cartilage at the nanoscale
    Hadi Tavakoli Nia
    Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Biophys J 101:2304-13. 2011
    ..These findings enable ongoing investigations of the nanoscale progression of matrix pathology in tissue-level disease...
  7. ncbi Mechanical injury of cartilage explants causes specific time-dependent changes in chondrocyte gene expression
    Jennifer H Lee
    Massachusetts Institute of Technology, Cambridge, 02139, USA
    Arthritis Rheum 52:2386-95. 2005
    ..This study was undertaken to determine if injurious mechanical compression of cartilage explants results in changes at the level of gene transcription that may lead to subsequent degradation of the cartilage...
  8. ncbi Mechanical compression of cartilage explants induces multiple time-dependent gene expression patterns and involves intracellular calcium and cyclic AMP
    Jonathan B Fitzgerald
    Biological Engineering Division, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    J Biol Chem 279:19502-11. 2004
    ..Immediate early genes c-fos and c-jun were dramatically up-regulated 6-30-fold, respectively, during the first 8 h of 50% compression and remained up-regulated after 24 h...
  9. ncbi Transcranial direct current stimulation: a computer-based human model study
    Tim Wagner
    Center for Non Invasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Neuroimage 35:1113-24. 2007
    ..This paper presents a realistic magnetic resonance imaging (MRI)-derived finite element model of currents applied to the human brain during tDCS...
  10. ncbi Transcranial magnetic stimulation and stroke: a computer-based human model study
    Tim Wagner
    Center for Non Invasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Neuroimage 30:857-70. 2006
    ....
  11. pmc Transcranial magnetic stimulation and brain atrophy: a computer-based human brain model study
    Tim Wagner
    Division of Health Sciences and Technology, Harvard Medical School Massachusetts Institute of Technology, Boston, MA, USA
    Exp Brain Res 186:539-50. 2008
    ..Clinical applications of TMS should be carefully considered in light of these findings...
  12. pmc Transport and equilibrium uptake of a peptide inhibitor of PACE4 into articular cartilage is dominated by electrostatic interactions
    Sangwon Byun
    Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Arch Biochem Biophys 499:32-9. 2010
    ....
  13. doi Mechanical injury potentiates proteoglycan catabolism induced by interleukin-6 with soluble interleukin-6 receptor and tumor necrosis factor alpha in immature bovine and adult human articular cartilage
    Yihong Sui
    Massachusetts Institute of Technology, Cambridge, MA 01239, USA
    Arthritis Rheum 60:2985-96. 2009
    ....
  14. ncbi Three-dimensional head model simulation of transcranial magnetic stimulation
    Tim A Wagner
    Harvard Massachusetts Institute of Technology s Division of Health Sciences and Technology program, Cambridge, MA 02139, USA
    IEEE Trans Biomed Eng 51:1586-98. 2004
    ..Finally, by varying the tissue permittivity values and the source frequency, we tested the effects of alpha dispersion theories on transcranial magnetic stimulation...
  15. ncbi Mechanisms and kinetics of glycosaminoglycan release following in vitro cartilage injury
    Michael A DiMicco
    Massachusetts Institute of Technology and Children s Hospital, Boston, Massachusetts 02139, USA
    Arthritis Rheum 50:840-8. 2004
    ....
  16. ncbi Transport and binding of insulin-like growth factor I through articular cartilage
    A Minerva Garcia
    Continuum Electromechanics Group, Center for Biomedical Engineering, Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Arch Biochem Biophys 415:69-79. 2003
    ....
  17. ncbi Proteoglycan degradation after injurious compression of bovine and human articular cartilage in vitro: interaction with exogenous cytokines
    Parth Patwari
    Center for Biomedical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Arthritis Rheum 48:1292-301. 2003
    ..We undertook this study to measure aspects of proteoglycan (PG) degradation after in vitro injurious mechanical compression, including up-regulation of enzymatic degradative expression and cytokine-stimulated degradation...
  18. ncbi Nanomechanics of opposing glycosaminoglycan macromolecules
    Joonil Seog
    Department of Mechanical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, MIT 13 4022, Cambridge, MA 02139, USA
    J Biomech 38:1789-97. 2005
    ....
  19. pmc Cartilage aggrecan can undergo self-adhesion
    Lin Han
    Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Biophys J 95:4862-70. 2008
    ....
  20. ncbi Tissue-engineered versus native cartilage: linkage between cellular mechano-transduction and biomechanical properties
    Jennifer H Lee
    Biological Engineering Division, Massachusetts Institute of Technology, Cambridge MA 02139 4307, USA
    Novartis Found Symp 249:52-64; discussion 64-9, 170-4, 239-41. 2003
    ..The in vivo environment should thereby signal tissue-specific maturation and integration processes in order to achieve the most appropriate tissue morphology and biomechanical function...
  21. doi A sodium dodecyl sulfate-polyacrylamide gel electrophoresis-liquid chromatography tandem mass spectrometry analysis of bovine cartilage tissue response to mechanical compression injury and the inflammatory cytokines tumor necrosis factor alpha and interle
    Anna L Stevens
    Massachusetts Institute of Technology, Cambridge 02139, USA
    Arthritis Rheum 58:489-500. 2008
    ....
  22. pmc Vulnerability of the superficial zone of immature articular cartilage to compressive injury
    Bernd Rolauffs
    Massachusetts Institute of Technology, Cambridge, Rush University Medical Center, Chicago, Illinois, USA
    Arthritis Rheum 62:3016-27. 2010
    ..Since injury to immature knee joints most often causes articular cartilage lesions, this study was undertaken to characterize the zonal dependence of biomechanical, biochemical, and matrix-associated changes caused by compressive injury...
  23. ncbi Nanomechanical properties of individual chondrocytes and their developing growth factor-stimulated pericellular matrix
    Laurel Ng
    Biological Engineering Division, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    J Biomech 40:1011-23. 2007
    ..These studies give insight into the temporal evolution of the nanomechanical properties of the pericellar matrix relevant to the biomechanics and mechanobiology of tissue-engineered constructs for cartilage repair...
  24. doi Modulation of lubricin biosynthesis and tissue surface properties following cartilage mechanical injury
    Aled R C Jones
    Wyeth Research, Cambridge, Massachusetts 02140, USA
    Arthritis Rheum 60:133-42. 2009
    ..To evaluate the effects of injurious compression on the biosynthesis of lubricin at different depths within articular cartilage and to examine alterations in structure and function of the articular surface following mechanical injury...
  25. pmc Analysis of the relationship between peak stress and proteoglycan loss following injurious compression of human post-mortem knee and ankle cartilage
    Parth Patwari
    Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, USA
    Biomech Model Mechanobiol 6:83-9. 2007
    ..However, we observed further evidence for differences in the response of knee and ankle cartilages to injury...
  26. ncbi Individual cartilage aggrecan macromolecules and their constituent glycosaminoglycans visualized via atomic force microscopy
    Laurel Ng
    Biological Engineering Division, Massachusetts Institute of Technology, Cambridge, MA, USA
    J Struct Biol 143:242-57. 2003
    ....
  27. ncbi Compressive nanomechanics of opposing aggrecan macromolecules
    Delphine Dean
    Department of Electrical Engineering and Computer Science, 77 Massachusetts Avenue, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    J Biomech 39:2555-65. 2006
    ....
  28. pmc Mechanical injury and cytokines cause loss of cartilage integrity and upregulate proteins associated with catabolism, immunity, inflammation, and repair
    Anna L Stevens
    Biological Engineering Department, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Mol Cell Proteomics 8:1475-89. 2009
    ....
  29. ncbi Combined effects of dynamic tissue shear deformation and insulin-like growth factor I on chondrocyte biosynthesis in cartilage explants
    Moonsoo Jin
    Continuum Electromechanics Group, Center for Biomedical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Arch Biochem Biophys 414:223-31. 2003
    ....
  30. doi Catabolic responses of chondrocyte-seeded peptide hydrogel to dynamic compression
    John D Kisiday
    Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA
    Ann Biomed Eng 37:1368-75. 2009
    ..These data suggest that partially mature cartilage tissue engineering constructs may be susceptible to catabolic degradation...
  31. pmc Dynamic mechanical properties of the tissue-engineered matrix associated with individual chondrocytes
    Bobae Lee
    Department of Materials Science and Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    J Biomech 43:469-76. 2010
    ..This trend of a more elastic-like response was thought to be associated with increased macromolecular biosynthesis, density, and a more mature matrix structure/organization...
  32. pmc Proliferative remodeling of the spatial organization of human superficial chondrocytes distant from focal early osteoarthritis
    Bernd Rolauffs
    Massachusetts Institute of Technology, Cambridge, MA, USA
    Arthritis Rheum 62:489-98. 2010
    ..The aim of this study was to determine whether remodeling or destruction of the spatial chondrocyte organization might occur at a distance from focal (early) lesions in patients with OA...
  33. pmc Self-assembling peptide hydrogels modulate in vitro chondrogenesis of bovine bone marrow stromal cells
    Paul W Kopesky
    Department of Biological Engineering, MIT, Cambridge, Massachusetts 02139, USA
    Tissue Eng Part A 16:465-77. 2010
    ..Taken together, this study demonstrates that self-assembling peptide hydrogels enhance chondrogenesis compared with agarose as shown by extracellular matrix production, DNA content, and aggrecan molecular structure...
  34. ncbi Shear- and compression-induced chondrocyte transcription requires MAPK activation in cartilage explants
    Jonathan B Fitzgerald
    Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Biol Chem 283:6735-43. 2008
    ..Thus, we demonstrated that the MAPK pathway is a central conduit for transducing mechanical forces into biological responses in cartilage...
  35. pmc A coarse-grained molecular model for glycosaminoglycans: application to chondroitin, chondroitin sulfate, and hyaluronic acid
    Mark Bathe
    Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, 02139, USA
    Biophys J 88:3870-87. 2005
    ..Model predictions agree quantitatively with experimental conformation and titration measurements, which support use of the model in the investigation of equilibrium solution properties of GAGs...
  36. ncbi Effects of dynamic compressive loading on chondrocyte biosynthesis in self-assembling peptide scaffolds
    John D Kisiday
    Biological Engineering Division, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    J Biomech 37:595-604. 2004
    ..Taken together, these results demonstrate the potential of dynamic compression for stimulating PG synthesis and accumulation for applications to in vitro culture of tissue engineered constructs prior to implantation...
  37. ncbi Chondrocyte mechanotransduction: effects of compression on deformation of intracellular organelles and relevance to cellular biosynthesis
    Jon D Szafranski
    Biological Engineering Division and Center for Biomedical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Osteoarthritis Cartilage 12:937-46. 2004
    ..The goal of this study was to examine the effects of tissue deformation on the morphology of a range of intracellular organelles which play a major role in cell biosynthesis and metabolism...
  38. pmc Lateral nanomechanics of cartilage aggrecan macromolecules
    Lin Han
    Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Biophys J 92:1384-98. 2007
    ..These data provide insights into molecular-level deformation of aggrecan macromolecules that are important to the understanding of cartilage behavior...
  39. ncbi Evaluation of medium supplemented with insulin-transferrin-selenium for culture of primary bovine calf chondrocytes in three-dimensional hydrogel scaffolds
    John D Kisiday
    Biological Engineering Division, Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Tissue Eng 11:141-51. 2005
    ..Taken together, ITS was suitable as a partial (peptide) or complete (agarose) substitute for serum, and also provided the benefit of reducing or eliminating cell outgrowth and fibrous capsule formation on the hydrogel surface...
  40. pmc Nanoscale shear deformation mechanisms of opposing cartilage aggrecan macromolecules
    Lin Han
    Department of Materials Science, Massachusetts Institute of Technology, Cambridge, MA, USA
    Biophys J 93:L23-5. 2007
    ..These results provide molecular-level insights into the contribution of aggrecan deformation mechanisms to cartilage tissue-level material properties...
  41. pmc Osmotic pressure of aqueous chondroitin sulfate solution: a molecular modeling investigation
    Mark Bathe
    Department of Mechanical Engineering, The Massachusetts Institute of Technology, Cambridge, MA, USA
    Biophys J 89:2357-71. 2005
    ..Osmotic pressure predictions are compared to experimental data and to well-established theoretical models including the Donnan theory and the Poisson-Boltzmann cylindrical cell model...
  42. ncbi Shear and compression differentially regulate clusters of functionally related temporal transcription patterns in cartilage tissue
    Jonathan B Fitzgerald
    Biological Engineering Division, Center for Biomedical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Biol Chem 281:24095-103. 2006
    ..Pre-incubating cartilage explants with either a chelator of intracellular calcium or an inhibitor of the cyclic AMP pathway demonstrated the involvement of both pathways in transcription induced by dynamic loading...
  43. pmc Distinct horizontal patterns in the spatial organization of superficial zone chondrocytes of human joints
    Bernd Rolauffs
    Massachusetts Institute of Technology, Center for Biomedical Engineering, Cambridge, MA 02139, USA
    J Struct Biol 162:335-44. 2008
    ..001). Further studies need to establish whether these organizational patterns are a consequence of their surrounding environment or whether they are linked to a functional purpose...
  44. ncbi Preservation and analysis of nonequilibrium solute concentration distributions within mechanically compressed cartilage explants
    Thomas M Quinn
    EPFL, Biomedical Engineering Laboratory, Swiss Federal Institute of Technology, CH 1015 Lausanne, Switzerland
    J Biochem Biophys Methods 52:83-95. 2002
    ....
  45. ncbi Mechanical regulation of mitogen-activated protein kinase signaling in articular cartilage
    Paul J Fanning
    Massachusetts General Hospital, Orthopaedic Research Laboratories, and Harvard Medical School, Boston, Massachusetts, USA
    J Biol Chem 278:50940-8. 2003
    ..Finally, the data indicate that compression coactivates distinct signaling pathways that may help define the nature of mechanotransduction in cartilage...
  46. ncbi Influence of tissue maturation and antioxidants on the apoptotic response of articular cartilage after injurious compression
    Bodo Kurz
    Anatomisches Institut der Christian Albrechts Universit├Ąt, Kiel, Kiel, Germany
    Arthritis Rheum 50:123-30. 2004
    ..To study the influence of tissue maturation and antioxidants on apoptosis in bovine articular cartilage induced by injurious compression...
  47. doi Gene expression profiles of human chondrocytes during passaged monolayer cultivation
    Zhen Lin
    Centre of Orthopaedic Surgery, University of Western Australia, M Block, QEII Medical Centre, Monash Avenue, Nedlands, Western Australia 6009, Australia
    J Orthop Res 26:1230-7. 2008
    ..This data may prove important for the future development of more specific and efficacious cultivation techniques for human articular chondrocyte-based therapies...
  48. pmc Mechanical overload induces VEGF in cartilage discs via hypoxia-inducible factor
    Thomas Pufe
    Department of Anatomy, University of Kiel, Kiel, Germany
    Am J Pathol 164:185-92. 2004
    ..Taking together, these findings indicate that VEGF is induced in chondrocytes by mechanical overload and mediates destructive processes in osteoarthritis as an autocrine factor...
  49. ncbi In vivo transplantation of neonatal ovine neocartilage allografts: determining the effectiveness of tissue transglutaminase
    Yan Lu
    School of Veterinary Medicine, University of Wisconsin Madison, Wisc 53706 1102, USA
    J Knee Surg 18:31-42. 2005
    ..Use of tTG to augment resorbable suture fixation of neocartilage grafts provided no advantage over suture alone in this pilot study...
  50. ncbi Articular cartilage and osteoarthritis
    Joseph A Buckwalter
    Department of Orthopaedics, University of Iowa, Iowa City, USA
    Instr Course Lect 54:465-80. 2005
    ..Investigation regarding the pathogenesis of posttraumatic osteoarthritis, the form of osteoarthritis that develops following joint injury, is helping to explain the development and progression of joint degeneration...
  51. pmc A comparative study of the inhibitory effects of interleukin-1 receptor antagonist following administration as a recombinant protein or by gene transfer
    Jean Noel Gouze
    Center for Molecular Orthopaedics, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Arthritis Res Ther 5:R301-9. 2003
    ..This was particularly evident under conditions of continuous IL-1beta synthesis...
  52. ncbi Role of aggrecanase 1 in Lyme arthritis
    Aruna K Behera
    Tupper Research Institute, Tufts University School of Medicine, Boston, Massachusetts, USA
    Arthritis Rheum 54:3319-29. 2006
    ..The role of aggrecanases in Lyme arthritis has not yet been determined. We therefore sought to delineate the contribution of aggrecanases to joint destruction in Lyme arthritis...
  53. ncbi In vitro gene transfer to chondrocytes and synovial fibroblasts by adenoviral vectors
    Jean Noel Gouze
    Center for Molecular Orthopaedics, Harvard Medical School, Boston, MA, USA
    Methods Mol Med 100:147-64. 2004
    ..This is intended to serve as an example of a technology that can be used to evaluate the biological effects of overexpression of other cDNAs...
  54. ncbi Pathomechanisms of cartilage destruction by mechanical injury
    Bodo Kurz
    Anatomisches Institut der Christian Albrechts Universit├Ąt zu Kiel, Olshausenstrasse 40, D 24098, Kiel, Germany
    Ann Anat 187:473-85. 2005
    ..This review summarizes some of the most important data from in vitro injury studies dealing with the pathomechanisms of cartilage destruction...
  55. pmc Local myocardial insulin-like growth factor 1 (IGF-1) delivery with biotinylated peptide nanofibers improves cell therapy for myocardial infarction
    Michael E Davis
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02139, USA
    Proc Natl Acad Sci U S A 103:8155-60. 2006
    ..Finally, cell therapy with IGF-1 delivery by biotinylated nanofibers improved systolic function after experimental myocardial infarction, demonstrating how engineering the local cellular microenvironment can improve cell therapy...

Research Grants31

  1. Chondrocyte Response to Load: Transduction and Molecular Mechanism
    Alan Grodzinsky; Fiscal Year: 2007
    ....
  2. Chondrocyte Response to Cartilage Injury
    Alan Grodzinsky; Fiscal Year: 2007
    ..abstract_text> ..
  3. Chondrocyte Response to Load: Transduction and Molec Mech
    Alan Grodzinsky; Fiscal Year: 2009
    ..abstract_text> ..
  4. Chondrocyte Response to Load: Transduction and Molec Mech
    Alan J Grodzinsky; Fiscal Year: 2010
    ..abstract_text> ..
  5. ELECTROMECHANICS OF CARTILAGE: SYNTHESIS & DEGRADATIION
    Alan Grodzinsky; Fiscal Year: 1993
    ..We propose to test the second hypothesis in the same experimental configuration by correlating proteoglycan and collagen synthetic response to applied mechanical and electrical stresses, using calf cartilage in organ culture...
  6. MECHANISMS OF CHONDROCYTE RESPONSE TO MECHANICAL STIMULI
    Alan Grodzinsky; Fiscal Year: 2002
    ....
  7. Self-Assembling Peptides for Tissue Engineering
    Alan Grodzinsky; Fiscal Year: 2009
    ..The lead institution of the Partnership is MIT, with partners from BWH and CSU. ..