Francine Grodstein

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc Anti-inflammatory agents and cognitive decline in a bi-racial population
    Francine Grodstein
    Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, IL, USA
    Neuroepidemiology 30:45-50. 2008
  2. pmc Postmenopausal hormone therapy and stroke: role of time since menopause and age at initiation of hormone therapy
    Francine Grodstein
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 181 Longwood Ave, Boston, Massachusetts 02115, USA
    Arch Intern Med 168:861-6. 2008
  3. pmc Shorter telomeres may mark early risk of dementia: preliminary analysis of 62 participants from the nurses' health study
    Francine Grodstein
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts, USA
    PLoS ONE 3:e1590. 2008
  4. pmc Vitamin E, vitamin C, beta carotene, and cognitive function among women with or at risk of cardiovascular disease: The Women's Antioxidant and Cardiovascular Study
    Jae Hee Kang
    Harvard School of Public Health, Boston, Mass, USA
    Circulation 119:2772-80. 2009
  5. pmc Cumulative exposure to lead and cognition in persons with Parkinson's disease
    Jennifer Weuve
    Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, Illinois 60612, USA
    Mov Disord 28:176-82. 2013
  6. pmc Dietary fat types and 4-year cognitive change in community-dwelling older women
    Olivia I Okereke
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Ann Neurol 72:124-34. 2012
  7. pmc A profile of impaired insulin degradation in relation to late-life cognitive decline: a preliminary investigation
    Olivia I Okereke
    Division of Aging, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Int J Geriatr Psychiatry 24:177-82. 2009
  8. pmc Dietary fat intake and cognitive decline in women with type 2 diabetes
    ELIZABETH E DEVORE
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Diabetes Care 32:635-40. 2009
  9. pmc Oral contraceptive use and incident urinary incontinence in premenopausal women
    Mary K Townsend
    Department of Medicine, Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Urol 181:2170-5. 2009
  10. ncbi request reprint Type 2 diabetes mellitus and risk of developing urinary incontinence
    Karen L Lifford
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Am Geriatr Soc 53:1851-7. 2005

Research Grants

  1. Risk Factors for Urinary Incontinence in Women
    Francine Grodstein; Fiscal Year: 2005
  2. TRIALS OF PREVENTION OF COGNITIVE DECLINE IN WOMEN
    Francine Grodstein; Fiscal Year: 2005
  3. Plasma Amyloid-Beta, Insulin, and Cognitive Decline
    Francine Grodstein; Fiscal Year: 2005
  4. Plasma Amyloid-Beta, Insulin, and Cognitive Decline
    Francine Grodstein; Fiscal Year: 2005
  5. Risk Factors for Urinary Incontinence in Women
    Francine Grodstein; Fiscal Year: 2006
  6. TRIALS OF PREVENTION OF COGNITIVE DECLINE IN WOMEN
    Francine Grodstein; Fiscal Year: 2006
  7. Plasma Amyloid-Beta, Insulin, and Cognitive Decline
    Francine Grodstein; Fiscal Year: 2006
  8. TRIALS OF PREVENTION OF COGNITIVE DECLINE IN WOMEN
    Francine Grodstein; Fiscal Year: 2007
  9. Plasma Amyloid-Beta, Insulin, and Cognitive Decline
    Francine Grodstein; Fiscal Year: 2007
  10. Risk Factors for Urinary Incontinence in Women
    Francine Grodstein; Fiscal Year: 2009

Detail Information

Publications97

  1. pmc Anti-inflammatory agents and cognitive decline in a bi-racial population
    Francine Grodstein
    Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, IL, USA
    Neuroepidemiology 30:45-50. 2008
    ..no use: mean difference = 0.12; p trend = 0.03). Overall, we found no relation between regular aspirin use and cognitive decline, but long-term use of ibuprofen may be related to decreased rates of cognitive decline in older persons...
  2. pmc Postmenopausal hormone therapy and stroke: role of time since menopause and age at initiation of hormone therapy
    Francine Grodstein
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 181 Longwood Ave, Boston, Massachusetts 02115, USA
    Arch Intern Med 168:861-6. 2008
    ..We evaluated stroke risk associated with hormone therapy (HT) in younger women, in recently menopausal women, and in older women...
  3. pmc Shorter telomeres may mark early risk of dementia: preliminary analysis of 62 participants from the nurses' health study
    Francine Grodstein
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts, USA
    PLoS ONE 3:e1590. 2008
    ..Since telomeres shorten with age and oxidative stress, both of which are important contributors to the onset of dementia, telomere length might be a valuable biomarker...
  4. pmc Vitamin E, vitamin C, beta carotene, and cognitive function among women with or at risk of cardiovascular disease: The Women's Antioxidant and Cardiovascular Study
    Jae Hee Kang
    Harvard School of Public Health, Boston, Mass, USA
    Circulation 119:2772-80. 2009
    ..Cardiovascular factors are associated with cognitive decline. Antioxidants may be beneficial...
  5. pmc Cumulative exposure to lead and cognition in persons with Parkinson's disease
    Jennifer Weuve
    Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, Illinois 60612, USA
    Mov Disord 28:176-82. 2013
    ..06). Patella bone lead concentration was not consistently associated with performance on the tests. These data provide evidence suggesting that cumulative exposure to lead may result in worsened cognition among persons with PD...
  6. pmc Dietary fat types and 4-year cognitive change in community-dwelling older women
    Olivia I Okereke
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Ann Neurol 72:124-34. 2012
    ..A study was undertaken to relate dietary fat types to cognitive change in healthy community-based elders...
  7. pmc A profile of impaired insulin degradation in relation to late-life cognitive decline: a preliminary investigation
    Olivia I Okereke
    Division of Aging, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Int J Geriatr Psychiatry 24:177-82. 2009
    ..In preliminary analyses, we considered the relation of combined lower insulin secretion (c-peptide) and higher insulin--possibly a phenotype for impaired insulin degradation--to cognitive decline...
  8. pmc Dietary fat intake and cognitive decline in women with type 2 diabetes
    ELIZABETH E DEVORE
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Diabetes Care 32:635-40. 2009
    ..We investigated whether dietary fat, which modulates glucose and lipid metabolism, might influence cognitive decline in older adults with diabetes...
  9. pmc Oral contraceptive use and incident urinary incontinence in premenopausal women
    Mary K Townsend
    Department of Medicine, Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Urol 181:2170-5. 2009
    ..We investigated the association between oral contraceptive pills and incident urinary incontinence in premenopausal women enrolled in the Nurses' Health Study II...
  10. ncbi request reprint Type 2 diabetes mellitus and risk of developing urinary incontinence
    Karen L Lifford
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Am Geriatr Soc 53:1851-7. 2005
    ..To evaluate the association between type 2 diabetes mellitus (DM) and development of urinary incontinence in women...
  11. pmc Fasting plasma insulin, C-peptide and cognitive change in older men without diabetes: results from the Physicians' Health Study II
    Olivia I Okereke
    Divisions of Aging, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Neuroepidemiology 34:200-7. 2010
    ..We examined prospectively relations of fasting insulin levels and insulin secretion to cognitive decline among healthy, community-dwelling older men without diabetes...
  12. pmc Plasma C-peptide levels and rates of cognitive decline in older, community-dwelling women without diabetes
    Olivia I Okereke
    Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Psychoneuroendocrinology 33:455-61. 2008
    ....
  13. pmc Lead exposure and rate of change in cognitive function in older women
    Melinda C Power
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA Department of Environmental Health, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA Electronic address
    Environ Res 129:69-75. 2014
    ..Higher long-term cumulative lead exposure predicts faster cognitive decline in older men, but evidence of an association in women is lacking...
  14. pmc Seafood types and age-related cognitive decline in the Women's Health Study
    Dae Hyun Kim
    SM, Channing Division of Network Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 181 Longwood Ave, Boston, MA 02115
    J Gerontol A Biol Sci Med Sci 68:1255-62. 2013
    ..However, benefits may vary by nutrient contents in different seafood types. We examined associations between total seafood consumption and cognitive decline and whether these associations differ by seafood types...
  15. ncbi request reprint Effects of moderate alcohol consumption on cognitive function in women
    Meir J Stampfer
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, USA
    N Engl J Med 352:245-53. 2005
    ..The adverse effects of excess alcohol intake on cognitive function are well established, but the effect of moderate consumption is uncertain...
  16. ncbi request reprint Postmenopausal hormone therapy and risk of cognitive decline in community-dwelling aging women
    Jae H Kang
    Channing Lab, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Neurology 63:101-7. 2004
    ..However, questions remain, including the effect of longer duration or of hormone therapy initiated at younger ages...
  17. pmc A trial of B vitamins and cognitive function among women at high risk of cardiovascular disease
    Jae Hee Kang
    Channing Laboratory, Boston, MA 02115, USA
    Am J Clin Nutr 88:1602-10. 2008
    ..High homocysteine concentrations may be neurotoxic and contribute to cognitive decline in older persons...
  18. ncbi request reprint Plasma C-peptide and cognitive performance in older men without diabetes
    Olivia Okereke
    Division of Aging, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA, USA
    Am J Geriatr Psychiatry 14:1041-50. 2006
    ..Emerging evidence suggests that type 2 diabetes may be related to diminished cognition, but little data are available directly regarding the role of insulin levels...
  19. pmc Ten-year change in plasma amyloid beta levels and late-life cognitive decline
    Olivia I Okereke
    Division of Aging and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Ave, Third Floor, Boston, MA 02115, USA
    Arch Neurol 66:1247-53. 2009
    ..Plasma levels of amyloid beta peptide (Abeta) are potential biomarkers of early cognitive impairment and decline and of Alzheimer disease risk...
  20. ncbi request reprint Apolipoprotein E, cardiovascular disease and cognitive function in aging women
    Jae Hee Kang
    Department of Medicine, Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, 181 Longwood Ave, Boston, MA 02115, USA
    Neurobiol Aging 26:475-84. 2005
    ..Thus, APOE genotypes strongly influenced cognitive function and decline; prevention of cardiovascular disease may limit these effects...
  21. ncbi request reprint Body mass index, weight gain, and incident urinary incontinence in middle-aged women
    Mary K Townsend
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Obstet Gynecol 110:346-53. 2007
    ..To describe the relations between body mass index (BMI; kg/m(2)), weight gain, and incident urinary incontinence in middle-aged women...
  22. ncbi request reprint Physical activity, including walking, and cognitive function in older women
    Jennifer Weuve
    Department of Epidemiology, Harvard School of Public Health, Boston, Mass 02215, USA
    JAMA 292:1454-61. 2004
    ..Physical activity may help maintain cognitive function in older adults...
  23. pmc Mediterranean diet and cognitive function in older age
    Cecilia Samieri
    Department of Medicine, Channing Division of Network Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Epidemiology 24:490-9. 2013
    ..Adherence to a Mediterranean diet may help prevent cognitive decline in older age, but studies are limited. We examined the association of adherence to the Mediterranean diet with cognitive function and decline...
  24. pmc The association of antioxidants and cognition in the Nurses' Health Study
    ELIZABETH E DEVORE
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Epidemiol 177:33-41. 2013
    ..Overall, long-term vitamin E and C intakes were not consistently related to cognition, although greater consumption of carotenoids may have cognitive benefits in older adults...
  25. pmc Dietary intakes of berries and flavonoids in relation to cognitive decline
    ELIZABETH E DEVORE
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA, USA
    Ann Neurol 72:135-43. 2012
    ..We prospectively evaluated whether greater long-term intakes of berries and flavonoids are associated with slower rates of cognitive decline in older women...
  26. pmc Alcohol consumption at midlife and successful ageing in women: a prospective cohort analysis in the nurses' health study
    Qi Sun
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, United States of America
    PLoS Med 8:e1001090. 2011
    ..In this study, we prospectively examined alcohol use assessed at midlife in relation to successful ageing in a cohort of US women...
  27. ncbi request reprint A randomized trial of vitamin E supplementation and cognitive function in women
    Jae Hee Kang
    Channing Laboratory, Boston, MA 02115, USA
    Arch Intern Med 166:2462-8. 2006
    ..Oxidative stress may play a key role in the development of cognitive impairment. Long-term supplementation with vitamin E, a strong antioxidant, may provide cognitive benefits...
  28. ncbi request reprint Hormone therapy and coronary heart disease: the role of time since menopause and age at hormone initiation
    Francine Grodstein
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Womens Health (Larchmt) 15:35-44. 2006
    ..Apparently discrepant findings have been reported by the Women's Health Initiative (WHI) trial compared with observational studies of postmenopausal hormone therapy (HT) and coronary heart disease (CHD)...
  29. pmc Low dose aspirin and cognitive function in the women's health study cognitive cohort
    Jae Hee Kang
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    BMJ 334:987. 2007
    ..To determine whether low dose aspirin protects women aged 65 or more against cognitive decline...
  30. ncbi request reprint Postmenopausal hormone therapy and risk of developing urinary incontinence
    Francine Grodstein
    Channing Laboratory and Renal Division, Department of Medicine, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    Obstet Gynecol 103:254-60. 2004
    ..To better understand associations between post-menopausal hormone therapy and the development of urinary incontinence...
  31. pmc Original research: rates of remission, improvement, and progression of urinary incontinence in Asian, Black, and White women
    Mary K Townsend
    Brigham and Women s Hospital, Harvard Medical School, Boston, USA
    Am J Nurs 111:26-33; quiz 34-5. 2011
    ..Evidence suggests that race affects the prevalence and incidence of urinary incontinence (UI) in women. But little is known about racial differences in the rates of remission, improvement, and progression of UI in women...
  32. ncbi request reprint Type 2 diabetes mellitus and cognitive decline in two large cohorts of community-dwelling older adults
    Olivia I Okereke
    Division of Aging and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Am Geriatr Soc 56:1028-36. 2008
    ..To relate diabetes mellitus (DM) status and duration to late-life cognitive impairment and decline in men and women...
  33. pmc Risk factors for urinary incontinence among middle-aged women
    Kim N Danforth
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Am J Obstet Gynecol 194:339-45. 2006
    ..The purpose of this study was to identify risk factors for urinary incontinence in middle-aged women...
  34. pmc Factors associated with persistent urinary incontinence
    ELIZABETH E DEVORE
    Channing Division of Network Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Obstet Gynecol 209:145.e1-6. 2013
    ..Many women with urinary incontinence (UI) have symptoms that continue over many years; however, virtually nothing is known about factors that are associated with persistent UI...
  35. doi request reprint The epidemiology of urinary incontinence in older women: incidence, progression, and remission
    Karen L Lifford
    Department of Medicine, Channing Laboratory, School of Public Health, Harvard University, Boston, Massachusetts, USA
    J Am Geriatr Soc 56:1191-8. 2008
    ..To examine the epidemiology of urinary incontinence (UI) in older women...
  36. doi request reprint BMI, waist circumference, and incident urinary incontinence in older women
    Mary K Townsend
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Obesity (Silver Spring) 16:881-6. 2008
    ..77). Waist circumference was associated only with stress UI (P for trend <0.001). These results suggest that women who avoid high BMI and waist circumference may have a lower risk of UI development...
  37. ncbi request reprint Physical activity and urinary incontinence among healthy, older women
    Kim N Danforth
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Obstet Gynecol 109:721-7. 2007
    ..To examine the association between physical activity and risk of developing urinary incontinence (UI)...
  38. pmc Incidence and remission of urinary incontinence in middle-aged women
    Mary K Townsend
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Obstet Gynecol 197:167.e1-5. 2007
    ..The objective of the study was to describe changes in urinary incontinence in middle-aged women...
  39. pmc The incidence of urinary incontinence across Asian, black, and white women in the United States
    Mary K Townsend
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Obstet Gynecol 202:378.e1-7. 2010
    ..We calculated incidence rates of urinary incontinence by incontinence frequency and type over 4 years in Asian, black, and white women in the United States...
  40. pmc Observational studies analyzed like randomized experiments: an application to postmenopausal hormone therapy and coronary heart disease
    Miguel A Hernán
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Epidemiology 19:766-79. 2008
    ..Observational studies had previously suggested reduced CHD risk in hormone users...
  41. pmc Total antioxidant capacity of diet in relation to cognitive function and decline
    ELIZABETH E DEVORE
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Am J Clin Nutr 92:1157-64. 2010
    ..Epidemiologic evidence on the association of individual antioxidant vitamins and cognition is inconsistent...
  42. pmc The relation of education and income to cognitive function among professional women
    Sunmin Lee
    Department of Health and Behavioral Sciences, University of Colorado at Denver and Health Sciences Center, Denver, CO 80217 3364, and Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Neuroepidemiology 26:93-101. 2006
    ..0001). Results were generally similar for cognitive decline over 2 years, although slightly weaker. Thus, in these well-educated, professional women, educational attainment and income both predicted cognitive function and decline...
  43. ncbi request reprint Do breast-feeding and other reproductive factors influence future risk of rheumatoid arthritis? Results from the Nurses' Health Study
    Elizabeth W Karlson
    Brigham and Women s Hospital, Harvard Medical School, and Harvard School of Public Health, 75 Francis Street, Boston, MA 02115, USA
    Arthritis Rheum 50:3458-67. 2004
    ....
  44. pmc The relation between moderate alcohol consumption and cognitive function in older women with type 2 diabetes
    Mary K Townsend
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Diabetes Res Clin Pract 85:322-7. 2009
    ..To examine the association between moderate drinking, cognitive function, and cognitive decline in women with type 2 diabetes...
  45. pmc Postmenopausal hormone therapy, timing of initiation, APOE and cognitive decline
    Jae H Kang
    Channing Lab, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Neurobiol Aging 33:1129-37. 2012
    ..Regardless of timing of initiation, HT may be associated with worse rates of decline in general cognition, especially among those with an APOE e4 allele...
  46. pmc Caffeine intake and risk of urinary incontinence progression among women
    Mary K Townsend
    Channing Laboratory, Boston, MA 02115, USA
    Obstet Gynecol 119:950-7. 2012
    ..To estimate the association between long-term caffeine intake and risk of urinary incontinence (UI) progression over 2 years among women with moderate UI...
  47. pmc Kidney dysfunction and cognitive decline in women
    Imran Sajjad
    Renal Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    Clin J Am Soc Nephrol 7:437-43. 2012
    ..ESRD is associated with substantial cognitive deficits but whether earlier kidney dysfunction predicts cognitive decline is less well defined...
  48. pmc Relation between insulin, insulin-related factors, and plasma amyloid beta peptide levels at midlife in a population-based study
    Mary K Townsend
    Department of Epidemiology, Harvard School of Public Health, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Alzheimer Dis Assoc Disord 26:50-4. 2012
    ....
  49. pmc Physical activity at midlife in relation to successful survival in women at age 70 years or older
    Qi Sun
    Department of Nutrition, Harvard School of Public Health, 655 Huntington Ave, Boston, MA 02115, USA
    Arch Intern Med 170:194-201. 2010
    ..Physical activity is associated with reduced risks of chronic diseases and premature death. Whether physical activity is also associated with improved overall health among those who survive to older ages is unclear...
  50. pmc Physical activity levels and cognition in women with type 2 diabetes
    ELIZABETH E DEVORE
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Epidemiol 170:1040-7. 2009
    ..Results were similar for cognitive decline. These findings indicate little overall association between physical activity and cognition after adjustment for disability factors in older women with type 2 diabetes...
  51. pmc Postmenopausal hormone therapy and incident urinary incontinence in middle-aged women
    Mary K Townsend
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Am J Obstet Gynecol 200:86.e1-5. 2009
    ..The objective of the study was to examine the association of hormone therapy with incident urinary incontinence (UI) in postmenopausal women aged 37-54 years in the Nurses' Health Study II...
  52. pmc Physical activity and incident urinary incontinence in middle-aged women
    Mary K Townsend
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Urol 179:1012-6; discussion 1016-7. 2008
    ..While strenuous, high impact activity may provoke urinary incontinence, little is known about relations with moderate physical activity. We examined recreational activity and incident urinary incontinence in middle-aged women...
  53. ncbi request reprint Fruit and vegetable consumption and cognitive decline in aging women
    Jae H Kang
    Channing Lab, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Ann Neurol 57:713-20. 2005
    ..05 unit; 95% confidence interval, 0.02, 0.09; p trend < 0.001). These mean differences were equivalent to those observed for women about 1 to 2 years apart in age...
  54. ncbi request reprint High-dose antioxidant supplements and cognitive function in community-dwelling elderly women
    Francine Grodstein
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Clin Nutr 77:975-84. 2003
    ..Experimental data suggest that oxygen free radicals are probably involved in the deterioration of cognitive processes...
  55. pmc Acidic fruit intake in relation to incidence and progression of urinary incontinence
    Mary K Townsend
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Room 452, Boston, MA 02115, USA
    Int Urogynecol J 24:605-12. 2013
    ..We hypothesized that higher intake of acidic fruits might be related to greater risk of UI incidence and progression in women...
  56. ncbi request reprint Regular use of nonsteroidal anti-inflammatory drugs and cognitive function in aging women
    Jae Hee Kang
    Channing Lab, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, MA 02115, USA
    Neurology 60:1591-7. 2003
    ..To examine the relationship of nonsteroidal anti-inflammatory drug (NSAID) use and cognitive decline in young-old women...
  57. ncbi request reprint The association of self-reported sleep duration, difficulty sleeping, and snoring with cognitive function in older women
    Shelley S Tworoger
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Alzheimer Dis Assoc Disord 20:41-8. 2006
    ..However, the lack of an association with prospective cognitive decline warrants further investigation...
  58. pmc Menopause, postmenopausal hormone use and risk of incident gout
    A Elisabeth Hak
    Section of Rheumatology and the Clinical Epidemiology Unit, Boston University of School of Medicine, 650 Albany Street, Suite 200, Boston, MA 02118, USA
    Ann Rheum Dis 69:1305-9. 2010
    ..To prospectively study the relation between menopause, postmenopausal hormone use and risk of gout, since female sex hormones have been postulated to decrease gout risk among women...
  59. pmc Caffeine intake, and the risk of stress, urgency and mixed urinary incontinence
    Ying H Jura
    Department of Urology, Massachusetts General Hospital, Boston, Massachusetts, USA
    J Urol 185:1775-80. 2011
    ..Although caffeine consumption is common and generally believed to affect bladder function, little is known about caffeine intake and incident urinary incontinence...
  60. ncbi request reprint Association of age, race, and obstetric history with urinary symptoms among women in the Nurses' Health Study
    Francine Grodstein
    Channing Laboratory, The Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Obstet Gynecol 189:428-34. 2003
    ..The purpose of this study was to better understand associations among age, race, obstetric history, and urinary incontinence in women...
  61. pmc Type 2 diabetes mellitus and risk of stress, urge and mixed urinary incontinence
    Kim N Danforth
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Urol 181:193-7. 2009
    ....
  62. ncbi request reprint Smoking and cognitive function in Parkinson's disease
    Marc G Weisskopf
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02215, USA
    Mov Disord 22:660-5. 2007
    ..Analyses of pack-years of smoking prior to disease onset gave similar results. These findings, nested in prospective cohort studies, suggest that cigarette smoking prior to disease onset is associated with worse cognitive function in PD...
  63. pmc A randomized trial of beta carotene supplementation and cognitive function in men: the Physicians' Health Study II
    Francine Grodstein
    Channing Laboratory, School of Public Health, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Arch Intern Med 167:2184-90. 2007
    ..Oxidative stress contributes to brain aging. Antioxidant treatment, especially over the long term, might confer cognitive benefits...
  64. pmc Long-term adherence to the Mediterranean diet is associated with overall cognitive status, but not cognitive decline, in women
    Cecilia Samieri
    Channing Division of Network Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    J Nutr 143:493-9. 2013
    ..These associations were similar to those observed in women 1-1.5 y apart in age. In summary, long-term MeDi adherence was related to moderately better cognition but not with cognitive change in this very large cohort of older women...
  65. pmc Risk factors for fecal incontinence in older women
    Mary K Townsend
    Channing Division of Network Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Gastroenterol 108:113-9. 2013
    ..The objectives of this study were to estimate the prevalence of fecal incontinence (FI) in older women and examine associations between potential risk factors and prevalent FI...
  66. pmc The epidemiology of urinary incontinence in women with type 2 diabetes
    ELIZABETH E DEVORE
    Channing Laboratory, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Urol 188:1816-21. 2012
    ..We examined prevalence, incidence and risk factors for urinary incontinence among women with type 2 diabetes in the NHS (Nurses' Health Study) and NHS II...
  67. ncbi request reprint Does caregiving stress affect cognitive function in older women?
    Sunmin Lee
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 181 Longwood Ave, Boston, MA 02115, USA
    J Nerv Ment Dis 192:51-7. 2004
    ..31, 95% CI 1.10, 1.56). We found a moderately increased risk of poor performance on several cognitive tests among women who provided care to their disabled or ill husbands...
  68. pmc Reducing case ascertainment costs in U.S. population studies of Alzheimer's disease, dementia, and cognitive impairment-Part 2
    Denis A Evans
    Rush Institute on Healthy Aging, Rush University Medical Center, Chicago, IL, USA
    Alzheimers Dement 7:110-23. 2011
    ....
  69. ncbi request reprint Plasma IGF-I levels and cognitive performance in older women
    Olivia Okereke
    Division of Aging, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, 3rd Floor, 181 Longwood Avenue, Boston, MA 02115, USA
    Neurobiol Aging 28:135-42. 2007
    ..Emerging biologic and epidemiologic evidence suggests benefits of insulin-like growth factor-I (IGF-I) in cognitive aging...
  70. pmc Relative telomere length and cognitive decline in the Nurses' Health Study
    ELIZABETH E DEVORE
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Neurosci Lett 492:15-8. 2011
    ..g. the differences that we observe between women who are 73 versus 74 years of age); thus, our results suggest that telomere length is not a particularly powerful marker of impending cognitive decline...
  71. pmc Fluid intake and risk of stress, urgency, and mixed urinary incontinence
    Mary K Townsend
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Am J Obstet Gynecol 205:73.e1-6. 2011
    ..We investigated the relation between total fluid intake and incident urinary incontinence in the Nurses' Health Study cohorts...
  72. pmc Performance characteristics of plasma amyloid-beta 40 and 42 assays
    Olivia I Okereke
    Division of Aging, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02115, USA
    J Alzheimers Dis 16:277-85. 2009
    ..While these preliminary findings suggest that measuring plasma Abeta(40) and Abeta(42) may be feasible in varied research settings, additional work in this area is necessary...
  73. ncbi request reprint Plasma C peptide level and cognitive function among older women without diabetes mellitus
    Olivia Okereke
    Division of Aging, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
    Arch Intern Med 165:1651-6. 2005
    ..To help differentiate between the effects of diabetes and insulin, we examined the relation of insulin to cognitive function among nondiabetic participants of the Nurses' Health Study...
  74. ncbi request reprint Midlife plasma insulin-like growth factor I and cognitive function in older men
    Olivia I Okereke
    Division of Aging, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Endocrinol Metab 91:4306-12. 2006
    ..Emerging biological and epidemiological evidence suggests possible benefits of higher IGF-I levels in cognitive aging...
  75. ncbi request reprint Prospective study of plasma folate, vitamin B12, and cognitive function and decline
    Jae Hee Kang
    Department of Medicine, Channing Laboratory, Brigham and Women s Hospital, Boston, MA, USA
    Epidemiology 17:650-7. 2006
    ..The relation between B vitamins and cognitive decline is controversial. In this study, we explored the association of plasma folate and vitamin B12 with cognitive function measured approximately 10 years later...
  76. ncbi request reprint Effects of marital transitions on changes in dietary and other health behaviours in US women
    Sunmin Lee
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Int J Epidemiol 34:69-78. 2005
    ..With a prospective design and repeated measures of variables, we sought to analyse the temporal relation between marital transition and change in health behaviours...
  77. ncbi request reprint Prevalence and effects of lobar microhemorrhages in early-stage dementia
    Alireza Atri
    Department of Neurology, Massachusetts General Hospital, Boston, MA, USA
    Neurodegener Dis 2:305-12. 2005
    ..The prevalence and effects of LMH detectable by gradient echo MRI (GE-MRI) in early-stage dementia are unknown...
  78. pmc Cumulative exposure to lead in relation to cognitive function in older women
    Jennifer Weuve
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Health Perspect 117:574-80. 2009
    ..Recent data indicate that chronic low-level exposure to lead is associated with accelerated declines in cognition in older age, but this has not been examined in women...
  79. ncbi request reprint High-sensitivity C-reactive protein and cognitive function in older women
    Jennifer Weuve
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Epidemiology 17:183-9. 2006
    ..Inflammatory processes may be involved in the development of dementia, although findings from epidemiologic studies directly examining inflammatory markers and dementia or its precursor, impaired cognitive function, are inconsistent...
  80. ncbi request reprint Prospective study of sudden cardiac death among women in the United States
    Christine M Albert
    Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, 900 Commonwealth Ave East, Boston, Mass 02215 1204, USA
    Circulation 107:2096-101. 2003
    ..Nonetheless, existing data, although sparse, suggest possible gender differences in risk factors for SCD...
  81. ncbi request reprint Total hip replacement due to osteoarthritis: the importance of age, obesity, and other modifiable risk factors
    Elizabeth W Karlson
    Division of Rheumatology, Immunology, and Allergy, Robert B Brigham Arthritis and Musculoskeletal Diseases Clinical Research Center, Boston, Massachusetts, USA
    Am J Med 114:93-8. 2003
    ..In the Nurses' Health Study, higher body mass index and older age significantly increased the risk of total hip replacement due to osteoarthritis. Part of this risk appeared to be established early in life...
  82. ncbi request reprint Cataract extraction and cognitive function in older women
    Francine Grodstein
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Epidemiology 14:493-7. 2003
    ..Oxidative damage is critical in the etiology of cataract. Therefore, associations between cataract and other health endpoints may suggest the shared etiologic role of oxidative stress...
  83. ncbi request reprint Coffee consumption and risk of rheumatoid arthritis
    Elizabeth W Karlson
    Harvard Medical School, and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Arthritis Rheum 48:3055-60. 2003
    ..We studied whether coffee, decaffeinated coffee, total coffee, tea, or overall caffeine consumption was associated with the risk of RA, using the Nurses' Health Study, a longitudinal cohort study of 121,701 women...
  84. ncbi request reprint Understanding the divergent data on postmenopausal hormone therapy
    Francine Grodstein
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    N Engl J Med 348:645-50. 2003
  85. pmc Plasma carotenoids and tocopherols and cognitive function: a prospective study
    Jae Hee Kang
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Neurobiol Aging 29:1394-403. 2008
    ..19, 0.09), and 0.04 units for total tocopherols (95% CI -0.10, 0.18). Individual antioxidants were not associated with cognition. Overall, total plasma carotenoids or tocopherols were not related to cognition in women...
  86. ncbi request reprint Postmenopausal hormone therapy and the risk of cardiovascular disease: the epidemiologic evidence
    Frank B Hu
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Am J Cardiol 90:26F-29F. 2002
    ..Existing evidence indicates that the various potential benefits and risks should be weighed carefully when prescribing hormone therapy to a postmenopausal woman...
  87. pmc Prospective study of type 2 diabetes and cognitive decline in women aged 70-81 years
    Giancarlo Logroscino
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    BMJ 328:548. 2004
    ..To examine the association of type 2 diabetes with baseline cognitive function and cognitive decline over two years of follow up, focusing on women living in the community and on the effects of treatments for diabetes...
  88. ncbi request reprint Education, other socioeconomic indicators, and cognitive function
    Sunmin Lee
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Epidemiol 157:712-20. 2003
    ..Thus, among well-educated women, educational attainment predicted cognitive function and decline, although other measures of socioeconomic status had little relation...
  89. pmc Fasting insulin levels and cognitive decline in older women without diabetes
    Marieke van Oijen
    Department of Epidemiology Biostatistics and Neurology, Erasmus Medical Center, Rotterdam, The Netherlands
    Neuroepidemiology 30:174-9. 2008
    ..Type 2 diabetes has been associated with an increased risk of dementia. To assess possible independent effects of insulin, we investigated the relation of insulin levels to cognitive decline in nondiabetic women...
  90. ncbi request reprint The discrepancy between observational studies and randomized trials of menopausal hormone therapy
    Francine Grodstein
    Ann Intern Med 140:764-5; author reply 765-6. 2004
  91. ncbi request reprint Postmenopausal hormone replacement therapy
    Francine Grodstein
    Ann Intern Med 138:688; author reply 688-9. 2003
  92. pmc Estrogen and progestogen use in postmenopausal women: July 2008 position statement of The North American Menopause Society
    Wulf H Utian
    Menopause 15:584-602. 2008
    ....
  93. ncbi request reprint Menopause and postmenopausal hormone use and risk of incident kidney stones
    Holly J Mattix Kramer
    Department of Preventive Medicine and Epidemiology, Loyola University Medical Center, Chicago, Illinois, USA
    J Am Soc Nephrol 14:1272-7. 2003
    ..In conclusion, no association was found between menopause and PMH use and incident kidney stones. Surgical menopause, however, may be associated with an increased risk...
  94. ncbi request reprint Re: "combined postmenopausal hormone therapy and cardiovascular disease: toward resolving the discrepancy between observational studies and the women's health initiative clinical trial"
    Walter C Willett
    Am J Epidemiol 163:1067-8; author reply 1068-9. 2006
  95. ncbi request reprint Prospective study of postmenopausal hormone use and newly diagnosed asthma and chronic obstructive pulmonary disease
    R Graham Barr
    Department of Medicine, Brigham and Women s Hospital, Massachusetts General Hospital, Harvard Medical School, Boston, Massachesetts, USA
    Arch Intern Med 164:379-86. 2004
    ..Therefore, in a prospective cohort study, we evaluated whether postmenopausal hormone use was associated with an increased rate of newly diagnosed asthma and, separately, newly diagnosed COPD...
  96. ncbi request reprint Relationship between hormone replacement therapy, socioeconomic status, and coronary heart disease
    Francine Grodstein
    JAMA 289:44-5; author reply 45. 2003
  97. ncbi request reprint Can homocysteine be related to physical functioning?
    Meir J Stampfer
    Am J Med 113:610-1. 2002

Research Grants29

  1. Risk Factors for Urinary Incontinence in Women
    Francine Grodstein; Fiscal Year: 2005
    ..In addition, the establishment of these cohorts for studying incontinence will allow future investigations of many other issues, such as the effect of diet and various lifestyle habits. ..
  2. TRIALS OF PREVENTION OF COGNITIVE DECLINE IN WOMEN
    Francine Grodstein; Fiscal Year: 2005
    ..WHS has been extended until August 2004 and WACS until February 2006, thus there is a limited window of opportunity for taking advantage of the long-term follow-up. ..
  3. Plasma Amyloid-Beta, Insulin, and Cognitive Decline
    Francine Grodstein; Fiscal Year: 2005
    ..Thus, these two established populations provide a highly cost-efficient setting in which to examine biomarkers of early cognitive decline, and gender and genetic interactions. ..
  4. Plasma Amyloid-Beta, Insulin, and Cognitive Decline
    Francine Grodstein; Fiscal Year: 2005
    ..Thus, these two established populations provide a highly cost-efficient setting in which to examine biomarkers of early cognitive decline, and gender and genetic interactions. ..
  5. Risk Factors for Urinary Incontinence in Women
    Francine Grodstein; Fiscal Year: 2006
    ..In addition, the establishment of these cohorts for studying incontinence will allow future investigations of many other issues, such as the effect of diet and various lifestyle habits. ..
  6. TRIALS OF PREVENTION OF COGNITIVE DECLINE IN WOMEN
    Francine Grodstein; Fiscal Year: 2006
    ..WHS has been extended until August 2004 and WACS until February 2006, thus there is a limited window of opportunity for taking advantage of the long-term follow-up. ..
  7. Plasma Amyloid-Beta, Insulin, and Cognitive Decline
    Francine Grodstein; Fiscal Year: 2006
    ..Thus, these two established populations provide a highly cost-efficient setting in which to examine biomarkers of early cognitive decline, and gender and genetic interactions. ..
  8. TRIALS OF PREVENTION OF COGNITIVE DECLINE IN WOMEN
    Francine Grodstein; Fiscal Year: 2007
    ..WHS has been extended until August 2004 and WACS until February 2006, thus there is a limited window of opportunity for taking advantage of the long-term follow-up. ..
  9. Plasma Amyloid-Beta, Insulin, and Cognitive Decline
    Francine Grodstein; Fiscal Year: 2007
    ..Thus, these two established populations provide a highly cost-efficient setting in which to examine biomarkers of early cognitive decline, and gender and genetic interactions. ..
  10. Risk Factors for Urinary Incontinence in Women
    Francine Grodstein; Fiscal Year: 2009
    ....
  11. Plasma Amyloid-Beta, Insulin, and Cognitive Decline
    Francine Grodstein; Fiscal Year: 2004
    ..Thus, these two established populations provide a highly cost-efficient setting in which to examine biomarkers of early cognitive decline, and gender and genetic interactions. ..
  12. TRIALS OF PREVENTION OF COGNITIVE DECLINE IN WOMEN
    Francine Grodstein; Fiscal Year: 2004
    ..WHS has been extended until August 2004 and WACS until February 2006, thus there is a limited window of opportunity for taking advantage of the long-term follow-up. ..
  13. Risk Factors for Urinary Incontinence in Women
    Francine Grodstein; Fiscal Year: 2004
    ..In addition, the establishment of these cohorts for studying incontinence will allow future investigations of many other issues, such as the effect of diet and various lifestyle habits. ..
  14. PREVENTING COGNITIVE DECLINE--A PROSPECTIVE STUDY
    Francine Grodstein; Fiscal Year: 1999
    ..The Nurses' Health Study provides a highly cost-efficient setting to examine lifestyle and genetic influences which may be instrumental in preventing or delaying early decline in cognitive function. ..
  15. TRIALS OF PREVENTION OF COGNITIVE DECLINE IN WOMEN
    Francine Grodstein; Fiscal Year: 1999
    ..Because the trials are on- going, we have only a narrow window of opportunity to implement cognitive testing with adequate follow-up time. ..
  16. PREVENTING COGNITIVE DECLINE--A PROSPECTIVE STUDY
    Francine Grodstein; Fiscal Year: 2000
    ..The Nurses' Health Study provides a highly cost-efficient setting to examine lifestyle and genetic influences which may be instrumental in preventing or delaying early decline in cognitive function. ..
  17. TRIALS OF PREVENTION OF COGNITIVE DECLINE IN WOMEN AND M
    Francine Grodstein; Fiscal Year: 2000
    ..Because the trials are on- going, we have only a narrow window of opportunity to implement cognitive testing with adequate follow-up time. ..
  18. Risk Factors for Urinary Incontinence in Women
    Francine Grodstein; Fiscal Year: 2002
    ..In addition, the establishment of these cohorts for studying incontinence will allow future investigations of many other issues, such as the effect of diet and various lifestyle habits. ..
  19. PREVENTING COGNITIVE DECLINE--A PROSPECTIVE STUDY
    Francine Grodstein; Fiscal Year: 2001
    ..The Nurses' Health Study provides a highly cost-efficient setting to examine lifestyle and genetic influences which may be instrumental in preventing or delaying early decline in cognitive function. ..
  20. TRIALS OF PREVENTION OF COGNITIVE DECLINE IN WOMEN AND M
    Francine Grodstein; Fiscal Year: 2001
    ..Because the trials are on- going, we have only a narrow window of opportunity to implement cognitive testing with adequate follow-up time. ..
  21. PREVENTING COGNITIVE DECLINE--A PROSPECTIVE STUDY
    Francine Grodstein; Fiscal Year: 2002
    ..The Nurses' Health Study provides a highly cost-efficient setting to examine lifestyle and genetic influences which may be instrumental in preventing or delaying early decline in cognitive function. ..
  22. TRIALS OF PREVENTION OF COGNITIVE DECLINE IN WOMEN AND M
    Francine Grodstein; Fiscal Year: 2002
    ..Because the trials are on- going, we have only a narrow window of opportunity to implement cognitive testing with adequate follow-up time. ..
  23. PREVENTING COGNITIVE DECLINE--A PROSPECTIVE STUDY
    Francine Grodstein; Fiscal Year: 2003
    ..The Nurses' Health Study provides a highly cost-efficient setting to examine lifestyle and genetic influences which may be instrumental in preventing or delaying early decline in cognitive function. ..
  24. Risk Factors for Urinary Incontinence in Women
    Francine Grodstein; Fiscal Year: 2003
    ..In addition, the establishment of these cohorts for studying incontinence will allow future investigations of many other issues, such as the effect of diet and various lifestyle habits. ..
  25. Risk Factors for Urinary Incontinence in Women
    Francine Grodstein; Fiscal Year: 2010
    ....