Research Topics
Species | Francine GrodsteinSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
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Publications
Shorter telomeres may mark early risk of dementia: preliminary analysis of 62 participants from the nurses' health studyFrancine Grodstein
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts, USA
PLoS ONE 3:e1590. 2008..Since telomeres shorten with age and oxidative stress, both of which are important contributors to the onset of dementia, telomere length might be a valuable biomarker...- Anti-inflammatory agents and cognitive decline in a bi-racial populationFrancine Grodstein
Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, IL, USA
Neuroepidemiology 30:45-50. 2008..no use: mean difference = 0.12; p trend = 0.03). Overall, we found no relation between regular aspirin use and cognitive decline, but long-term use of ibuprofen may be related to decreased rates of cognitive decline in older persons... 
Postmenopausal hormone therapy and stroke: role of time since menopause and age at initiation of hormone therapyFrancine Grodstein
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 181 Longwood Ave, Boston, Massachusetts 02115, USA
Arch Intern Med 168:861-6. 2008..We evaluated stroke risk associated with hormone therapy (HT) in younger women, in recently menopausal women, and in older women...- Vitamin E, vitamin C, beta carotene, and cognitive function among women with or at risk of cardiovascular disease: The Women's Antioxidant and Cardiovascular StudyJae Hee Kang
Harvard School of Public Health, Boston, Mass, USA
Circulation 119:2772-80. 2009..Cardiovascular factors are associated with cognitive decline. Antioxidants may be beneficial... - Dietary fat types and 4-year cognitive change in community-dwelling older womenOlivia I Okereke
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
Ann Neurol 72:124-34. 2012..A study was undertaken to relate dietary fat types to cognitive change in healthy community-based elders... - Oral contraceptive use and incident urinary incontinence in premenopausal womenMary K Townsend
Department of Medicine, Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
J Urol 181:2170-5. 2009..We investigated the association between oral contraceptive pills and incident urinary incontinence in premenopausal women enrolled in the Nurses' Health Study II... - A profile of impaired insulin degradation in relation to late-life cognitive decline: a preliminary investigationOlivia I Okereke
Division of Aging, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Int J Geriatr Psychiatry 24:177-82. 2009..In preliminary analyses, we considered the relation of combined lower insulin secretion (c-peptide) and higher insulin--possibly a phenotype for impaired insulin degradation--to cognitive decline... - Dietary fat intake and cognitive decline in women with type 2 diabetesELIZABETH E DEVORE
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
Diabetes Care 32:635-40. 2009..We investigated whether dietary fat, which modulates glucose and lipid metabolism, might influence cognitive decline in older adults with diabetes... - Fasting plasma insulin, C-peptide and cognitive change in older men without diabetes: results from the Physicians' Health Study IIOlivia I Okereke
Divisions of Aging, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Neuroepidemiology 34:200-7. 2010..We examined prospectively relations of fasting insulin levels and insulin secretion to cognitive decline among healthy, community-dwelling older men without diabetes... 
Type 2 diabetes mellitus and risk of developing urinary incontinenceKaren L Lifford
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
J Am Geriatr Soc 53:1851-7. 2005..To evaluate the association between type 2 diabetes mellitus (DM) and development of urinary incontinence in women...- Plasma C-peptide levels and rates of cognitive decline in older, community-dwelling women without diabetesOlivia I Okereke
Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
Psychoneuroendocrinology 33:455-61. 2008.... - Postmenopausal hormone therapy and risk of cognitive decline in community-dwelling aging womenJae H Kang
Channing Lab, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Neurology 63:101-7. 2004..However, questions remain, including the effect of longer duration or of hormone therapy initiated at younger ages... - A trial of B vitamins and cognitive function among women at high risk of cardiovascular diseaseJae Hee Kang
Channing Laboratory, Boston, MA 02115, USA
Am J Clin Nutr 88:1602-10. 2008..High homocysteine concentrations may be neurotoxic and contribute to cognitive decline in older persons... - Effects of moderate alcohol consumption on cognitive function in womenMeir J Stampfer
Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, USA
N Engl J Med 352:245-53. 2005..g., wine or beer) and no interaction with the apolipoprotein E genotype. CONCLUSIONS: Our data suggest that in women, up to one drink per day does not impair cognitive function and may actually decrease the risk of cognitive decline... - Plasma C-peptide and cognitive performance in older men without diabetesOlivia Okereke
Division of Aging, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA, USA
Am J Geriatr Psychiatry 14:1041-50. 2006..Emerging evidence suggests that type 2 diabetes may be related to diminished cognition, but little data are available directly regarding the role of insulin levels... - Apolipoprotein E, cardiovascular disease and cognitive function in aging womenJae Hee Kang
Department of Medicine, Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, 181 Longwood Ave, Boston, MA 02115, USA
Neurobiol Aging 26:475-84. 2005..Thus, APOE genotypes strongly influenced cognitive function and decline; prevention of cardiovascular disease may limit these effects... - Ten-year change in plasma amyloid beta levels and late-life cognitive declineOlivia I Okereke
Division of Aging and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Ave, Third Floor, Boston, MA 02115, USA
Arch Neurol 66:1247-53. 2009..Plasma levels of amyloid beta peptide (Abeta) are potential biomarkers of early cognitive impairment and decline and of Alzheimer disease risk... - Body mass index, weight gain, and incident urinary incontinence in middle-aged womenMary K Townsend
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
Obstet Gynecol 110:346-53. 2007..To describe the relations between body mass index (BMI; kg/m(2)), weight gain, and incident urinary incontinence in middle-aged women... - Physical activity, including walking, and cognitive function in older womenJennifer Weuve
Department of Epidemiology, Harvard School of Public Health, Boston, Mass 02215, USA
JAMA 292:1454-61. 2004..Physical activity may help maintain cognitive function in older adults... - The association of antioxidants and cognition in the Nurses' Health StudyELIZABETH E DEVORE
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Am J Epidemiol 177:33-41. 2013..Overall, long-term vitamin E and C intakes were not consistently related to cognition, although greater consumption of carotenoids may have cognitive benefits in older adults... - Dietary intakes of berries and flavonoids in relation to cognitive declineELIZABETH E DEVORE
Channing Laboratory, Brigham and Women s Hospital, Boston, MA, USA
Ann Neurol 72:135-43. 2012..We prospectively evaluated whether greater long-term intakes of berries and flavonoids are associated with slower rates of cognitive decline in older women... - Alcohol consumption at midlife and successful ageing in women: a prospective cohort analysis in the nurses' health studyQi Sun
Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, United States of America
PLoS Med 8:e1001090. 2011..In this study, we prospectively examined alcohol use assessed at midlife in relation to successful ageing in a cohort of US women... - Hormone therapy and coronary heart disease: the role of time since menopause and age at hormone initiationFrancine Grodstein
Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
J Womens Health (Larchmt) 15:35-44. 2006..Apparently discrepant findings have been reported by the Women's Health Initiative (WHI) trial compared with observational studies of postmenopausal hormone therapy (HT) and coronary heart disease (CHD)... - Low dose aspirin and cognitive function in the women's health study cognitive cohortJae Hee Kang
Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
BMJ 334:987. 2007..To determine whether low dose aspirin protects women aged 65 or more against cognitive decline... - A randomized trial of vitamin E supplementation and cognitive function in womenJae Hee Kang
Channing Laboratory, Boston, MA 02115, USA
Arch Intern Med 166:2462-8. 2006..Oxidative stress may play a key role in the development of cognitive impairment. Long-term supplementation with vitamin E, a strong antioxidant, may provide cognitive benefits... - Type 2 diabetes mellitus and cognitive decline in two large cohorts of community-dwelling older adultsOlivia I Okereke
Division of Aging and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
J Am Geriatr Soc 56:1028-36. 2008..To relate diabetes mellitus (DM) status and duration to late-life cognitive impairment and decline in men and women... - Risk factors for urinary incontinence among middle-aged womenKim N Danforth
Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Am J Obstet Gynecol 194:339-45. 2006..The purpose of this study was to identify risk factors for urinary incontinence in middle-aged women... - Postmenopausal hormone therapy and risk of developing urinary incontinenceFrancine Grodstein
Channing Laboratory and Renal Division, Department of Medicine, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
Obstet Gynecol 103:254-60. 2004..To better understand associations between post-menopausal hormone therapy and the development of urinary incontinence... - Original research: rates of remission, improvement, and progression of urinary incontinence in Asian, Black, and White womenMary K Townsend
Brigham and Women s Hospital, Harvard Medical School, Boston, USA
Am J Nurs 111:26-33; quiz 34-5. 2011..Evidence suggests that race affects the prevalence and incidence of urinary incontinence (UI) in women. But little is known about racial differences in the rates of remission, improvement, and progression of UI in women... - The relation between moderate alcohol consumption and cognitive function in older women with type 2 diabetesMary K Townsend
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
Diabetes Res Clin Pract 85:322-7. 2009..To examine the association between moderate drinking, cognitive function, and cognitive decline in women with type 2 diabetes... - The epidemiology of urinary incontinence in older women: incidence, progression, and remissionKaren L Lifford
Department of Medicine, Channing Laboratory, School of Public Health, Harvard University, Boston, Massachusetts, USA
J Am Geriatr Soc 56:1191-8. 2008..To examine the epidemiology of urinary incontinence (UI) in older women... - Observational studies analyzed like randomized experiments: an application to postmenopausal hormone therapy and coronary heart diseaseMiguel A Hernán
Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
Epidemiology 19:766-79. 2008..Observational studies had previously suggested reduced CHD risk in hormone users... - Physical activity and urinary incontinence among healthy, older womenKim N Danforth
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Obstet Gynecol 109:721-7. 2007..To examine the association between physical activity and risk of developing urinary incontinence (UI)... - The incidence of urinary incontinence across Asian, black, and white women in the United StatesMary K Townsend
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Am J Obstet Gynecol 202:378.e1-7. 2010..We calculated incidence rates of urinary incontinence by incontinence frequency and type over 4 years in Asian, black, and white women in the United States... - Total antioxidant capacity of diet in relation to cognitive function and declineELIZABETH E DEVORE
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
Am J Clin Nutr 92:1157-64. 2010..Epidemiologic evidence on the association of individual antioxidant vitamins and cognition is inconsistent... - Do breast-feeding and other reproductive factors influence future risk of rheumatoid arthritis? Results from the Nurses' Health StudyElizabeth W Karlson
Brigham and Women s Hospital, Harvard Medical School, and Harvard School of Public Health, 75 Francis Street, Boston, MA 02115, USA
Arthritis Rheum 50:3458-67. 2004.... - BMI, waist circumference, and incident urinary incontinence in older womenMary K Townsend
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Obesity (Silver Spring) 16:881-6. 2008..77). Waist circumference was associated only with stress UI (P for trend <0.001). These results suggest that women who avoid high BMI and waist circumference may have a lower risk of UI development... - The relation of education and income to cognitive function among professional womenSunmin Lee
Department of Health and Behavioral Sciences, University of Colorado at Denver and Health Sciences Center, Denver, CO 80217 3364, and Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Neuroepidemiology 26:93-101. 2006..0001). Results were generally similar for cognitive decline over 2 years, although slightly weaker. Thus, in these well-educated, professional women, educational attainment and income both predicted cognitive function and decline... - Incidence and remission of urinary incontinence in middle-aged womenMary K Townsend
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Am J Obstet Gynecol 197:167.e1-5. 2007..The objective of the study was to describe changes in urinary incontinence in middle-aged women... - Kidney dysfunction and cognitive decline in womenImran Sajjad
Renal Division, Brigham and Women s Hospital, Boston, MA 02115, USA
Clin J Am Soc Nephrol 7:437-43. 2012..ESRD is associated with substantial cognitive deficits but whether earlier kidney dysfunction predicts cognitive decline is less well defined... - Caffeine intake and risk of urinary incontinence progression among womenMary K Townsend
Channing Laboratory, Boston, MA 02115, USA
Obstet Gynecol 119:950-7. 2012..To estimate the association between long-term caffeine intake and risk of urinary incontinence (UI) progression over 2 years among women with moderate UI... - Relation between insulin, insulin-related factors, and plasma amyloid beta peptide levels at midlife in a population-based studyMary K Townsend
Department of Epidemiology, Harvard School of Public Health, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
Alzheimer Dis Assoc Disord 26:50-4. 2012.... - Postmenopausal hormone therapy and incident urinary incontinence in middle-aged womenMary K Townsend
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
Am J Obstet Gynecol 200:86.e1-5. 2009..The objective of the study was to examine the association of hormone therapy with incident urinary incontinence (UI) in postmenopausal women aged 37-54 years in the Nurses' Health Study II... - Fruit and vegetable consumption and cognitive decline in aging womenJae H Kang
Channing Lab, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Ann Neurol 57:713-20. 2005..05 unit; 95% confidence interval, 0.02, 0.09; p trend < 0.001). These mean differences were equivalent to those observed for women about 1 to 2 years apart in age... - Physical activity at midlife in relation to successful survival in women at age 70 years or olderQi Sun
Department of Nutrition, Harvard School of Public Health, 655 Huntington Ave, Boston, MA 02115, USA
Arch Intern Med 170:194-201. 2010..Physical activity is associated with reduced risks of chronic diseases and premature death. Whether physical activity is also associated with improved overall health among those who survive to older ages is unclear... - Physical activity levels and cognition in women with type 2 diabetesELIZABETH E DEVORE
Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Am J Epidemiol 170:1040-7. 2009..Results were similar for cognitive decline. These findings indicate little overall association between physical activity and cognition after adjustment for disability factors in older women with type 2 diabetes... - Physical activity and incident urinary incontinence in middle-aged womenMary K Townsend
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
J Urol 179:1012-6; discussion 1016-7. 2008..While strenuous, high impact activity may provoke urinary incontinence, little is known about relations with moderate physical activity. We examined recreational activity and incident urinary incontinence in middle-aged women... - High-dose antioxidant supplements and cognitive function in community-dwelling elderly womenFrancine Grodstein
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Am J Clin Nutr 77:975-84. 2003..Experimental data suggest that oxygen free radicals are probably involved in the deterioration of cognitive processes... - Type 2 diabetes mellitus and risk of stress, urge and mixed urinary incontinenceKim N Danforth
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
J Urol 181:193-7. 2009.... - Caffeine intake, and the risk of stress, urgency and mixed urinary incontinenceYing H Jura
Department of Urology, Massachusetts General Hospital, Boston, Massachusetts, USA
J Urol 185:1775-80. 2011..Although caffeine consumption is common and generally believed to affect bladder function, little is known about caffeine intake and incident urinary incontinence... - A randomized trial of beta carotene supplementation and cognitive function in men: the Physicians' Health Study IIFrancine Grodstein
Channing Laboratory, School of Public Health, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
Arch Intern Med 167:2184-90. 2007..Oxidative stress contributes to brain aging. Antioxidant treatment, especially over the long term, might confer cognitive benefits... - Menopause, postmenopausal hormone use and risk of incident goutA Elisabeth Hak
Section of Rheumatology and the Clinical Epidemiology Unit, Boston University of School of Medicine, 650 Albany Street, Suite 200, Boston, MA 02118, USA
Ann Rheum Dis 69:1305-9. 2010..To prospectively study the relation between menopause, postmenopausal hormone use and risk of gout, since female sex hormones have been postulated to decrease gout risk among women... - Regular use of nonsteroidal anti-inflammatory drugs and cognitive function in aging womenJae Hee Kang
Channing Lab, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, MA 02115, USA
Neurology 60:1591-7. 2003..To examine the relationship of nonsteroidal anti-inflammatory drug (NSAID) use and cognitive decline in young-old women... - Association of age, race, and obstetric history with urinary symptoms among women in the Nurses' Health StudyFrancine Grodstein
Channing Laboratory, The Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Am J Obstet Gynecol 189:428-34. 2003..The purpose of this study was to better understand associations among age, race, obstetric history, and urinary incontinence in women... - Smoking and cognitive function in Parkinson's diseaseMarc G Weisskopf
Department of Environmental Health, Harvard School of Public Health, Boston, MA 02215, USA
Mov Disord 22:660-5. 2007..Analyses of pack-years of smoking prior to disease onset gave similar results. These findings, nested in prospective cohort studies, suggest that cigarette smoking prior to disease onset is associated with worse cognitive function in PD... - The association of self-reported sleep duration, difficulty sleeping, and snoring with cognitive function in older womenShelley S Tworoger
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Alzheimer Dis Assoc Disord 20:41-8. 2006..However, the lack of an association with prospective cognitive decline warrants further investigation... - Long-term adherence to the Mediterranean diet is associated with overall cognitive status, but not cognitive decline, in womenCecilia Samieri
Channing Division of Network Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
J Nutr 143:493-9. 2013..These associations were similar to those observed in women 1-1.5 y apart in age. In summary, long-term MeDi adherence was related to moderately better cognition but not with cognitive change in this very large cohort of older women... - Risk factors for fecal incontinence in older womenMary K Townsend
Channing Division of Network Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Am J Gastroenterol 108:113-9. 2013..The objectives of this study were to estimate the prevalence of fecal incontinence (FI) in older women and examine associations between potential risk factors and prevalent FI... - The epidemiology of urinary incontinence in women with type 2 diabetesELIZABETH E DEVORE
Channing Laboratory, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts 02115, USA
J Urol 188:1816-21. 2012..We examined prevalence, incidence and risk factors for urinary incontinence among women with type 2 diabetes in the NHS (Nurses' Health Study) and NHS II... - Does caregiving stress affect cognitive function in older women?Sunmin Lee
Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 181 Longwood Ave, Boston, MA 02115, USA
J Nerv Ment Dis 192:51-7. 2004..31, 95% CI 1.10, 1.56). We found a moderately increased risk of poor performance on several cognitive tests among women who provided care to their disabled or ill husbands... - Plasma IGF-I levels and cognitive performance in older womenOlivia Okereke
Division of Aging, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, 3rd Floor, 181 Longwood Avenue, Boston, MA 02115, USA
Neurobiol Aging 28:135-42. 2007..Emerging biologic and epidemiologic evidence suggests benefits of insulin-like growth factor-I (IGF-I) in cognitive aging... - Performance characteristics of plasma amyloid-beta 40 and 42 assaysOlivia I Okereke
Division of Aging, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02115, USA
J Alzheimers Dis 16:277-85. 2009..While these preliminary findings suggest that measuring plasma Abeta(40) and Abeta(42) may be feasible in varied research settings, additional work in this area is necessary... - Fluid intake and risk of stress, urgency, and mixed urinary incontinenceMary K Townsend
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
Am J Obstet Gynecol 205:73.e1-6. 2011..We investigated the relation between total fluid intake and incident urinary incontinence in the Nurses' Health Study cohorts... - Reducing case ascertainment costs in U.S. population studies of Alzheimer's disease, dementia, and cognitive impairment-Part 2Denis A Evans
Rush Institute on Healthy Aging, Rush University Medical Center, Chicago, IL, USA
Alzheimers Dement 7:110-23. 2011.... - Relative telomere length and cognitive decline in the Nurses' Health StudyELIZABETH E DEVORE
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
Neurosci Lett 492:15-8. 2011..g. the differences that we observe between women who are 73 versus 74 years of age); thus, our results suggest that telomere length is not a particularly powerful marker of impending cognitive decline... - Effects of marital transitions on changes in dietary and other health behaviours in US womenSunmin Lee
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
Int J Epidemiol 34:69-78. 2005..With a prospective design and repeated measures of variables, we sought to analyse the temporal relation between marital transition and change in health behaviours... - Prospective study of plasma folate, vitamin B12, and cognitive function and declineJae Hee Kang
Department of Medicine, Channing Laboratory, Brigham and Women s Hospital, Boston, MA, USA
Epidemiology 17:650-7. 2006..The relation between B vitamins and cognitive decline is controversial. In this study, we explored the association of plasma folate and vitamin B12 with cognitive function measured approximately 10 years later... - Cumulative exposure to lead in relation to cognitive function in older womenJennifer Weuve
Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
Environ Health Perspect 117:574-80. 2009..Recent data indicate that chronic low-level exposure to lead is associated with accelerated declines in cognition in older age, but this has not been examined in women... - Midlife plasma insulin-like growth factor I and cognitive function in older menOlivia I Okereke
Division of Aging, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Clin Endocrinol Metab 91:4306-12. 2006..Emerging biological and epidemiological evidence suggests possible benefits of higher IGF-I levels in cognitive aging... - Prevalence and effects of lobar microhemorrhages in early-stage dementiaAlireza Atri
Department of Neurology, Massachusetts General Hospital, Boston, MA, USA
Neurodegener Dis 2:305-12. 2005..The prevalence and effects of LMH detectable by gradient echo MRI (GE-MRI) in early-stage dementia are unknown... - High-sensitivity C-reactive protein and cognitive function in older womenJennifer Weuve
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
Epidemiology 17:183-9. 2006..Inflammatory processes may be involved in the development of dementia, although findings from epidemiologic studies directly examining inflammatory markers and dementia or its precursor, impaired cognitive function, are inconsistent... - Plasma C peptide level and cognitive function among older women without diabetes mellitusOlivia Okereke
Division of Aging, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
Arch Intern Med 165:1651-6. 2005..To help differentiate between the effects of diabetes and insulin, we examined the relation of insulin to cognitive function among nondiabetic participants of the Nurses' Health Study... - Coffee consumption and risk of rheumatoid arthritisElizabeth W Karlson
Harvard Medical School, and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Arthritis Rheum 48:3055-60. 2003..We studied whether coffee, decaffeinated coffee, total coffee, tea, or overall caffeine consumption was associated with the risk of RA, using the Nurses' Health Study, a longitudinal cohort study of 121,701 women... - Prospective study of sudden cardiac death among women in the United StatesChristine M Albert
Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, 900 Commonwealth Ave East, Boston, Mass 02215 1204, USA
Circulation 107:2096-101. 2003..Nonetheless, existing data, although sparse, suggest possible gender differences in risk factors for SCD... - Total hip replacement due to osteoarthritis: the importance of age, obesity, and other modifiable risk factorsElizabeth W Karlson
Division of Rheumatology, Immunology, and Allergy, Robert B Brigham Arthritis and Musculoskeletal Diseases Clinical Research Center, Boston, Massachusetts, USA
Am J Med 114:93-8. 2003..In the Nurses' Health Study, higher body mass index and older age significantly increased the risk of total hip replacement due to osteoarthritis. Part of this risk appeared to be established early in life... - Cataract extraction and cognitive function in older womenFrancine Grodstein
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Epidemiology 14:493-7. 2003..Oxidative damage is critical in the etiology of cataract. Therefore, associations between cataract and other health endpoints may suggest the shared etiologic role of oxidative stress... - Education, other socioeconomic indicators, and cognitive functionSunmin Lee
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Am J Epidemiol 157:712-20. 2003..Thus, among well-educated women, educational attainment predicted cognitive function and decline, although other measures of socioeconomic status had little relation... - Understanding the divergent data on postmenopausal hormone therapyFrancine Grodstein
Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
N Engl J Med 348:645-50. 2003 - Prospective study of type 2 diabetes and cognitive decline in women aged 70-81 yearsGiancarlo Logroscino
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
BMJ 328:548. 2004..To examine the association of type 2 diabetes with baseline cognitive function and cognitive decline over two years of follow up, focusing on women living in the community and on the effects of treatments for diabetes... - Postmenopausal hormone therapy and the risk of cardiovascular disease: the epidemiologic evidenceFrank B Hu
Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Am J Cardiol 90:26F-29F. 2002..Existing evidence indicates that the various potential benefits and risks should be weighed carefully when prescribing hormone therapy to a postmenopausal woman... - Plasma carotenoids and tocopherols and cognitive function: a prospective studyJae Hee Kang
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Neurobiol Aging 29:1394-403. 2008..19, 0.09), and 0.04 units for total tocopherols (95% CI -0.10, 0.18). Individual antioxidants were not associated with cognition. Overall, total plasma carotenoids or tocopherols were not related to cognition in women... - The discrepancy between observational studies and randomized trials of menopausal hormone therapyFrancine Grodstein
Ann Intern Med 140:764-5; author reply 765-6. 2004 - Fasting insulin levels and cognitive decline in older women without diabetesMarieke van Oijen
Department of Epidemiology Biostatistics and Neurology, Erasmus Medical Center, Rotterdam, The Netherlands
Neuroepidemiology 30:174-9. 2008..Type 2 diabetes has been associated with an increased risk of dementia. To assess possible independent effects of insulin, we investigated the relation of insulin levels to cognitive decline in nondiabetic women... - Postmenopausal hormone replacement therapyFrancine Grodstein
Ann Intern Med 138:688; author reply 688-9. 2003 - Prospective study of postmenopausal hormone use and newly diagnosed asthma and chronic obstructive pulmonary diseaseR Graham Barr
Department of Medicine, Brigham and Women's Hospital, Massachusetts General Hospital, Harvard Medical School, Boston, Massachesetts, USA
Arch Intern Med 164:379-86. 2004..Female reproductive hormones may contribute to the onset of asthma among adult women, but do not appear to hasten the development of COPD... - Estrogen and progestogen use in postmenopausal women: July 2008 position statement of The North American Menopause SocietyWulf H Utian
Menopause 15:584-602. 2008..The benefit-risk ratio for menopausal HT is favorable close to menopause but decreases with aging and with time since menopause in previously untreated women... - Relationship between hormone replacement therapy, socioeconomic status, and coronary heart diseaseFrancine Grodstein
JAMA 289:44-5; author reply 45. 2003 - Re: "combined postmenopausal hormone therapy and cardiovascular disease: toward resolving the discrepancy between observational studies and the women's health initiative clinical trial"Walter C Willett
Am J Epidemiol 163:1067-8; author reply 1068-9. 2006 - Can homocysteine be related to physical functioning?Meir J Stampfer
Am J Med 113:610-1. 2002 - Menopause and postmenopausal hormone use and risk of incident kidney stonesHolly J Mattix Kramer
Department of Preventive Medicine and Epidemiology, Loyola University Medical Center, Chicago, Illinois, USA
J Am Soc Nephrol 14:1272-7. 2003..In conclusion, no association was found between menopause and PMH use and incident kidney stones. Surgical menopause, however, may be associated with an increased risk...
Research Grants
- Risk Factors for Urinary Incontinence in WomenFrancine Grodstein; Fiscal Year: 2006..In addition, the establishment of these cohorts for studying incontinence will allow future investigations of many other issues, such as the effect of diet and various lifestyle habits. ..
- TRIALS OF PREVENTION OF COGNITIVE DECLINE IN WOMENFrancine Grodstein; Fiscal Year: 2007..WHS has been extended until August 2004 and WACS until February 2006, thus there is a limited window of opportunity for taking advantage of the long-term follow-up. ..
- Plasma Amyloid-Beta, Insulin, and Cognitive DeclineFrancine Grodstein; Fiscal Year: 2007..Thus, these two established populations provide a highly cost-efficient setting in which to examine biomarkers of early cognitive decline, and gender and genetic interactions. ..
- Risk Factors for Urinary Incontinence in WomenFrancine Grodstein; Fiscal Year: 2009....
- TRIALS OF PREVENTION OF COGNITIVE DECLINE IN WOMEN AND MFrancine Grodstein; Fiscal Year: 2002..Because the trials are on- going, we have only a narrow window of opportunity to implement cognitive testing with adequate follow-up time. ..
- PREVENTING COGNITIVE DECLINE--A PROSPECTIVE STUDYFrancine Grodstein; Fiscal Year: 2003..The Nurses' Health Study provides a highly cost-efficient setting to examine lifestyle and genetic influences which may be instrumental in preventing or delaying early decline in cognitive function. ..
- Risk Factors for Urinary Incontinence in WomenFrancine Grodstein; Fiscal Year: 2010....