STEVEN KYLE GRINSPOON

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc Metabolic effects of a growth hormone-releasing factor in obese subjects with reduced growth hormone secretion: a randomized controlled trial
    Hideo Makimura
    Program in Nutritional Metabolism and Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 97:4769-79. 2012
  2. pmc Deiodinase 2 expression is increased in dorsocervical fat of patients with HIV-associated lipohypertrophy syndrome
    Martin Torriani
    Division of Musculoskeletal Imaging and Intervention and Program in Nutritional Metabolism, Massachusetts General Hospital Longfellow 207, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 97:E602-7. 2012
  3. ncbi request reprint Weight loss and wasting in patients infected with human immunodeficiency virus
    Steven Grinspoon
    Program in Nutritional Metabolism, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Clin Infect Dis 36:S69-78. 2003
  4. ncbi request reprint Characterization of leptin pulse dynamics and relationship to fat mass, growth hormone, cortisol, and insulin
    Polyxeni Koutkia
    Program in Nutritional Metabolism, Massachusetts General Hospital, LON 207, 55 Fruit St, Boston, MA 02114, USA
    Am J Physiol Endocrinol Metab 285:E372-9. 2003
  5. ncbi request reprint Cardiovascular risk and body-fat abnormalities in HIV-infected adults
    Steven Grinspoon
    Program in Nutritional Metabolism and the Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    N Engl J Med 352:48-62. 2005
  6. ncbi request reprint Mechanisms and strategies for insulin resistance in acquired immune deficiency syndrome
    Steven Grinspoon
    Harvard Medical School, Massachusetts General Hospital, Program in Nutritional Metabolism, Boston 02114, USA
    Clin Infect Dis 37:S85-90. 2003
  7. ncbi request reprint Sustained anabolic effects of long-term androgen administration in men with AIDS wasting
    S Grinspoon
    Infectious Disease Unit, and General Clinical Research Center, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Clin Infect Dis 28:634-6. 1999
  8. pmc Fracture prevalence among human immunodeficiency virus (HIV)-infected versus non-HIV-infected patients in a large U.S. healthcare system
    Virginia A Triant
    Program in Nutritional Metabolism, Massachusetts General Hospital, 55 Fruit Street, Longfellow 207, Boston, Massachusetts 02114
    J Clin Endocrinol Metab 93:3499-504. 2008
  9. ncbi request reprint Effects of estrogen and recombinant human insulin-like growth factor-I on ghrelin secretion in severe undernutrition
    Steven Grinspoon
    Neuroendocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 89:3988-93. 2004
  10. ncbi request reprint Metabolic syndrome and cardiovascular disease in patients with human immunodeficiency virus
    Steven K Grinspoon
    MGH Program in Nutritional Metabolism, Massachusetts General Hospital, 55 Fruit Street, LON 207, Boston, Massachusetts 02114 2696, USA
    Am J Med 118:23S-28S. 2005

Collaborators

Detail Information

Publications66

  1. pmc Metabolic effects of a growth hormone-releasing factor in obese subjects with reduced growth hormone secretion: a randomized controlled trial
    Hideo Makimura
    Program in Nutritional Metabolism and Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 97:4769-79. 2012
    ..Obesity is associated with reduced GH secretion and increased cardiovascular disease risk...
  2. pmc Deiodinase 2 expression is increased in dorsocervical fat of patients with HIV-associated lipohypertrophy syndrome
    Martin Torriani
    Division of Musculoskeletal Imaging and Intervention and Program in Nutritional Metabolism, Massachusetts General Hospital Longfellow 207, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 97:E602-7. 2012
    ....
  3. ncbi request reprint Weight loss and wasting in patients infected with human immunodeficiency virus
    Steven Grinspoon
    Program in Nutritional Metabolism, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Clin Infect Dis 36:S69-78. 2003
    ..Principles and guidelines for assessment and management of weight loss and wasting in patients with HIV/AIDS are presented...
  4. ncbi request reprint Characterization of leptin pulse dynamics and relationship to fat mass, growth hormone, cortisol, and insulin
    Polyxeni Koutkia
    Program in Nutritional Metabolism, Massachusetts General Hospital, LON 207, 55 Fruit St, Boston, MA 02114, USA
    Am J Physiol Endocrinol Metab 285:E372-9. 2003
    ..The directionality of the cross correlation suggests a temporal construct in which changes in leptin follow those of insulin but precede those of GH and cortisol during overnight fasting...
  5. ncbi request reprint Cardiovascular risk and body-fat abnormalities in HIV-infected adults
    Steven Grinspoon
    Program in Nutritional Metabolism and the Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    N Engl J Med 352:48-62. 2005
  6. ncbi request reprint Mechanisms and strategies for insulin resistance in acquired immune deficiency syndrome
    Steven Grinspoon
    Harvard Medical School, Massachusetts General Hospital, Program in Nutritional Metabolism, Boston 02114, USA
    Clin Infect Dis 37:S85-90. 2003
    ..Further studies are needed to determine the optimal treatment strategy for insulin resistance in this population...
  7. ncbi request reprint Sustained anabolic effects of long-term androgen administration in men with AIDS wasting
    S Grinspoon
    Infectious Disease Unit, and General Clinical Research Center, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Clin Infect Dis 28:634-6. 1999
    ..7 +/- 0.8 kg vs. 1.0 +/- 1.0 kg; P = .05). Testosterone administration results in sustained increases in LBM during 1 year of therapy in hypogonadal men with AIDS wasting...
  8. pmc Fracture prevalence among human immunodeficiency virus (HIV)-infected versus non-HIV-infected patients in a large U.S. healthcare system
    Virginia A Triant
    Program in Nutritional Metabolism, Massachusetts General Hospital, 55 Fruit Street, Longfellow 207, Boston, Massachusetts 02114
    J Clin Endocrinol Metab 93:3499-504. 2008
    ..Reduced bone mineral density has been demonstrated among HIV-infected patients, but fracture prevalence is unknown...
  9. ncbi request reprint Effects of estrogen and recombinant human insulin-like growth factor-I on ghrelin secretion in severe undernutrition
    Steven Grinspoon
    Neuroendocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 89:3988-93. 2004
    ..The mechanisms of these effects are unknown and may relate to direct effects on ghrelin or changes in GH. Further studies are needed to determine the mechanisms by which rhIGF-I and E increase ghrelin in human physiology...
  10. ncbi request reprint Metabolic syndrome and cardiovascular disease in patients with human immunodeficiency virus
    Steven K Grinspoon
    MGH Program in Nutritional Metabolism, Massachusetts General Hospital, 55 Fruit Street, LON 207, Boston, Massachusetts 02114 2696, USA
    Am J Med 118:23S-28S. 2005
    ..However, newer PIs such as atazanavir may result in less insulin resistance and dyslipidemia and, as part of a HAART regimen, use of atazanavir may reduce the metabolic complications associated with HAART...
  11. ncbi request reprint Effects of recombinant human insulin-like growth factor (IGF)-I and estrogen administration on IGF-I, IGF binding protein (IGFBP)-2, and IGFBP-3 in anorexia nervosa: a randomized-controlled study
    Steven Grinspoon
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 88:1142-9. 2003
    ..In conclusion, our data suggest that chronic rhIGF-I administration increases IGF-I and IGFBP-2 and decreases IGFBP-3 in women with anorexia nervosa. IGFBP-2 and IGFBP-3 may be important determinants of bone density in this population...
  12. pmc Relationship between neck circumference and cardiometabolic parameters in HIV-infected and non-HIV-infected adults
    Kathleen V Fitch
    Program in Nutritional Metabolism and Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Diabetes Care 34:1026-31. 2011
    ....
  13. ncbi request reprint Severity of osteopenia in estrogen-deficient women with anorexia nervosa and hypothalamic amenorrhea
    S Grinspoon
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    J Clin Endocrinol Metab 84:2049-55. 1999
    ..Lean body mass, independent of the duration or severity of estrogen deficiency, is an important predictor of bone loss among women with AN...
  14. ncbi request reprint Changes in regional fat redistribution and the effects of estrogen during spontaneous weight gain in women with anorexia nervosa
    S Grinspoon
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Am J Clin Nutr 73:865-9. 2001
    ..Anorexia nervosa is a disease of severe acquired undernutrition with a high and increasing prevalence among young women in the United States...
  15. ncbi request reprint Mechanisms of androgen deficiency in human immunodeficiency virus-infected women with the wasting syndrome
    S Grinspoon
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 86:4120-6. 2001
    ..Further studies of the mechanism of adrenal steroid shunting and the efficacy of androgen replacement in human immunodeficiency virus-infected women are necessary...
  16. ncbi request reprint Insulin resistance in the HIV-lipodystrophy syndrome
    S Grinspoon
    Neuroendocrine Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Trends Endocrinol Metab 12:413-9. 2001
    ..Furthermore, insulin-sensitizing agents might improve insulin resistance and reduce the risk of CVD in this population...
  17. ncbi request reprint Effects of recombinant human IGF-I and oral contraceptive administration on bone density in anorexia nervosa
    Steven Grinspoon
    Neuroendocrine Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Endocrinol Metab 87:2883-91. 2002
    ..Further long-term studies are needed to investigate the effects of rhIGF-I and combined anabolic/antiresorptive strategies on bone in women with anorexia nervosa...
  18. pmc Low-dose physiological growth hormone in patients with HIV and abdominal fat accumulation: a randomized controlled trial
    Janet Lo
    Program in Nutritional Metabolism, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA
    JAMA 300:509-19. 2008
    ..Antiretroviral therapy can be associated with visceral adiposity and metabolic complications, increasing cardiovascular risk, and reduced growth hormone (GH) secretion may be a contributing factor...
  19. pmc Improved triglycerides and insulin sensitivity with 3 months of acipimox in human immunodeficiency virus-infected patients with hypertriglyceridemia
    Colleen Hadigan
    Program in Nutritional Metabolism, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 91:4438-44. 2006
    ..Metabolic abnormalities such as hypertriglyceridemia remain a challenge for optimizing long-term health in HIV-infected patients...
  20. ncbi request reprint Metabolic regulation of growth hormone by free fatty acids, somatostatin, and ghrelin in HIV-lipodystrophy
    Polyxeni Koutkia
    Program in Nutritional Metabolism and Neuroendocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Am J Physiol Endocrinol Metab 286:E296-303. 2004
    ..These data provide novel insight into the metabolic regulation of GH secretion in subjects with HIV-lipodystrophy...
  21. ncbi request reprint Increased rates of lipolysis among human immunodeficiency virus-infected men receiving highly active antiretroviral therapy
    Colleen Hadigan
    Neuroendocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Metabolism 51:1143-7. 2002
    ..These data demonstrate increased rates of lipolysis and increased total FFA levels in HIV-infected subjects and suggest that increased lipolysis may contribute to insulin resistance in this patient population...
  22. ncbi request reprint Reduced intravertebral bone marrow fat in HIV-infected men
    Jeannie S Huang
    Massachusetts General Hospital, Neuroendocrine Unit, Boston, MA 02114, USA
    AIDS 16:1265-9. 2002
    ..To measure intravertebral bone marrow fat in HIV-infected men...
  23. ncbi request reprint Psoas muscle attenuation measurement with computed tomography indicates intramuscular fat accumulation in patients with the HIV-lipodystrophy syndrome
    Martin Torriani
    Division of Musculoskeletal Radiology, Massachusetts General Hospital, Boston, MA 02114, USA
    J Appl Physiol 95:1005-10. 2003
    ..Further studies are needed to assess the mechanisms and consequences of intramuscular lipid accumulation in HIV-infected patients...
  24. ncbi request reprint Effects of growth hormone-releasing hormone on bone turnover in human immunodeficiency virus-infected men with fat accumulation
    Polyxeni Koutkia
    Program in Nutritional Metabolism, Massachusetts General Hospital, 55 Fruit Street, LON 207, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 90:2154-60. 2005
    ..Long-term studies are needed to determine whether the stimulatory effects of GHRH on bone turnover will translate into increased bone density in this population...
  25. ncbi request reprint Increased cardiovascular disease risk indices in HIV-infected women
    Sara E Dolan
    Program in Nutritional Metabolism, General Clinical Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Acquir Immune Defic Syndr 39:44-54. 2005
    ..HIV-infected women demonstrate significantly increased risk factors for cardiovascular disease in association with abnormal fat distribution...
  26. ncbi request reprint Growth hormone-releasing hormone in HIV-infected men with lipodystrophy: a randomized controlled trial
    Polyxeni Koutkia
    Massachusetts General Hospital Program in Nutritional Metabolism and Neuroendocrine Unit, Harvard Medical School, Boston, Mass 02114, USA
    JAMA 292:210-8. 2004
    ..Reduced growth hormone (GH) concentrations are observed in men with human immunodeficiency virus (HIV) lipodystrophy...
  27. ncbi request reprint Acute regulation of adiponectin by free fatty acids
    Elizabeth L Bernstein
    Massachusetts General Hospital Program in Nutritional Metabolism and Neuroendocrine Unit, Harvard Medical School, Boston, MA, USA
    Metabolism 53:790-3. 2004
    ..66, P <.05), eg, the larger the reduction in FFA in response to acipimox, the larger the reduction in adiponectin. These results suggest that acute lowering of FFA is associated with decreased adiponectin concentrations...
  28. ncbi request reprint Reciprocal changes in endogenous ghrelin and growth hormone during fasting in healthy women
    Polyxeni Koutkia
    Program in Nutritional Metabolism, Mass General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Am J Physiol Endocrinol Metab 289:E814-22. 2005
    ..Our data provide new evidence of the physiological relationship of GH and ghrelin in response to changes in protein-energy metabolism...
  29. ncbi request reprint Body-composition measurements as predictors of glucose and insulin abnormalities in HIV-positive men
    Gary Meininger
    Neuroendocrine Unit, the Program in Nutritional Metabolism, Massachusetts General Hospital, and Harvard Medical School, Boston 02114, USA
    Am J Clin Nutr 76:460-5. 2002
    ..Fat redistribution and metabolic abnormalities are seen increasingly in HIV-positive patients. However, the degree to which abnormalities in fat distribution predict glucose and insulin concentrations in these patients remains unknown...
  30. ncbi request reprint Differential effects of metformin and exercise on muscle adiposity and metabolic indices in human immunodeficiency virus-infected patients
    Susan D Driscoll
    Program in Nutritional Metabolism, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 89:2171-8. 2004
    ..Reduction in muscle adiposity may be an important mechanism by which exercise improves hyperinsulinemia in this population...
  31. ncbi request reprint Growth hormone secretion among HIV infected patients: effects of gender, race and fat distribution
    Polyxeni Koutkia
    Massachusetts General Hospital Program in Nutritional Metabolism and Neuroendocrine Unit, Harvard Medical School, Boston, Massachusetts 02114, USA
    AIDS 20:855-62. 2006
    ..To determine the effects of gender, race, and fat redistribution on growth hormone (GH) secretory patterns in HIV-infected patients...
  32. ncbi request reprint Growth hormone (GH) responses to GH-releasing hormone-arginine testing in human immunodeficiency virus lipodystrophy
    Polyxeni Koutkia
    Program in Nutritional Metabolism, 55 Fruit Street, LON 207, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 90:32-8. 2005
    ..The effects of low-dose GH should be assessed in the large subset of LIPO patients with abnormal GH stimulation testing...
  33. ncbi request reprint Role of cytokines and testosterone in regulating lean body mass and resting energy expenditure in HIV-infected men
    Ronenn Roubenoff
    Department of Community Health, Jean Mayer US Department of Agriculture Human Nutrition Research Center, Tufts University, Boston, Massachusetts 02111, USA
    Am J Physiol Endocrinol Metab 283:E138-45. 2002
    ..Even though weight loss was rare in this cohort of patients treated with highly active antiretroviral therapy, loss of LBM was common and was driven by catabolic cytokines and not by inadequate dietary intake or hypogonadism...
  34. ncbi request reprint Effects of physiological leptin administration on markers of inflammation, platelet activation, and platelet aggregation during caloric deprivation
    Bridget Canavan
    Program in Nutritional Metabolism, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 90:5779-85. 2005
    ..However, the effects of leptin administration on markers of inflammation and platelet aggregation in a human model of undernutrition have not previously been studied...
  35. pmc Retinol-binding protein levels are increased in association with gonadotropin levels in healthy women
    Hideo Makimura
    Program in Nutritional Metabolism and Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Metabolism 58:479-87. 2009
    ..Retinol-binding protein was not associated with inflammatory markers or with carotid intima-media thickness. Therefore, RBP4 is higher in postmenopausal women and is associated with gonadotropin concentrations in healthy women...
  36. pmc Increased intramyocellular lipid accumulation in HIV-infected women with fat redistribution
    Martin Torriani
    Division of Musculoskeletal Radiology, Dept of Radiology, Massachusetts General Hospital, 55 Fruit St, YAW 6048, Boston, MA 02114, USA
    J Appl Physiol 100:609-14. 2006
    ..Further studies are necessary to determine the relationship between extremity fat loss and increased IMCL in HIV-infected women...
  37. pmc The effects of central adiposity on growth hormone (GH) response to GH-releasing hormone-arginine stimulation testing in men
    Hideo Makimura
    Program in Nutritional Metabolism, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, LON 211, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 93:4254-60. 2008
    ..The relative contribution of central adiposity vs. weight on GH response to stimulation testing in obesity is not known...
  38. pmc Longitudinal analysis of bone density in human immunodeficiency virus-infected women
    Sara E Dolan
    Program in Nutritional Metabolism, Massachusetts General Hospital, 55 Fruit Street, LON207, Boston, MA 02114, USA
    J Clin Endocrinol Metab 91:2938-45. 2006
    ..The objective of the study was to investigate change in bone mineral density (BMD) over time in HIV-infected women in comparison with healthy control subjects similar in age, race, and body mass index (BMI)...
  39. ncbi request reprint Effects of weight, body composition, and testosterone on bone mineral density in HIV-infected women
    Sara E Dolan
    Program in Nutritional Metabolism and Neuroendocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Acquir Immune Defic Syndr 45:161-7. 2007
    ..These data demonstrate that BMD is reduced among HIV-infected women in association with low weight, reduced lean mass, reduced androgen levels, and abnormal menstrual function...
  40. doi request reprint Gender effects on cardiac valvular function in hyperprolactinaemic patients receiving cabergoline: a retrospective study
    Lisa B Nachtigall
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Clin Endocrinol (Oxf) 72:53-8. 2010
    ..Ergot-derived dopamine agonists are associated with increased risk of valvular dysfunction in Parkinson's disease. The risk of valvular disease associated with lower doses of cabergoline used to treat prolactinomas remains controversial...
  41. ncbi request reprint Neurocognitive function in HIV-infected patients with low weight and weight loss
    Sara Dolan
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    J Acquir Immune Defic Syndr 34:155-64. 2003
    ..To determine neurocognitive function in HIV-infected subjects with low weight and weight loss...
  42. ncbi request reprint Serum osteoprotegerin in adolescent girls with anorexia nervosa
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 88:3816-22. 2003
    ..OPG values correlate negatively with markers of nutritional status and lumbar bone density z-scores and may be a compensatory response to the bone loss seen in this population...
  43. ncbi request reprint Elevated concentrations of free fatty acids are associated with increased insulin response to standard glucose challenge in human immunodeficiency virus-infected subjects with fat redistribution
    Gary Meininger
    Department of Pathology, Massachusetts General Hospital and Children s Hospital, Boston, MA 02114, USA
    Metabolism 51:260-6. 2002
    ..Further studies are necessary to determine the mechanism of increased fatty acid concentrations and the role played by increased FFA in mediating insulin resistance in this population...
  44. ncbi request reprint Prediction of coronary heart disease risk in HIV-infected patients with fat redistribution
    Colleen Hadigan
    Program in Nutritional Metabolism, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA
    Clin Infect Dis 36:909-16. 2003
    ..Therefore, although CHD risk is increased in HIV-infected patients with fat redistribution, the pattern of fat distribution and sex are potential important components in determining the risk in this population...
  45. ncbi request reprint Sustained benefits of metformin therapy on markers of cardiovascular risk in human immunodeficiency virus-infected patients with fat redistribution and insulin resistance
    Colleen Hadigan
    Neuroendocrine Unit and Program in Nutritional Metabolism, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 87:4611-5. 2002
    ..These data demonstrate a sustained benefit of metformin treatment to reduce hyperinsulinemia and certain markers of cardiovascular disease risk in patients with HIV infection and lipodystrophy...
  46. ncbi request reprint Effects of risedronate on bone density in anorexia nervosa
    Karen K Miller
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 89:3903-6. 2004
    ..S. for premenopausal women other than those receiving glucocorticoids. Further studies are needed to establish the efficacy and safety of bisphosphonate therapy in this population...
  47. ncbi request reprint Diagnostic errors after inferior petrosal sinus sampling
    Brooke Swearingen
    Neuroendocrine Clinical Center, Division of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 89:3752-63. 2004
    ....
  48. ncbi request reprint Metabolic effects of rosiglitazone in HIV lipodystrophy: a randomized, controlled trial
    Colleen Hadigan
    Massachusetts General Hospital and Brigham and Women s Hospital, Boston, Massachusetts 02114, USA
    Ann Intern Med 140:786-94. 2004
    ....
  49. ncbi request reprint Inhibition of lipolysis improves insulin sensitivity in protease inhibitor-treated HIV-infected men with fat redistribution
    Colleen Hadigan
    Neuroendocrine Unit and the Program in Nutritional Metabolism, Massachusetts General Hospital and Harvard Medical School, Boston, 02114, USA
    Am J Clin Nutr 77:490-4. 2003
    ..Fatty acid concentrations are increased in patients with HIV and fat redistribution and may contribute to insulin resistance in this population...
  50. pmc Relationship of peak growth hormone to cardiovascular parameters, waist circumference, lipids and glucose in HIV-infected patients and healthy adults
    Janet Lo
    Massachusetts General Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Clin Endocrinol (Oxf) 71:815-22. 2009
    ..Relative growth hormone (GH) deficiency is highly prevalent in patients with HIV. The purpose of this study was to investigate relationships of GH to metabolic and anthropometric parameters in HIV patients and non-HIV controls...
  51. ncbi request reprint Endocrine and metabolic effects of physiologic r-metHuLeptin administration during acute caloric deprivation in normal-weight women
    Sunita Schurgin
    Program in Nutritional Metabolism, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, LON 207, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 89:5402-9. 2004
    ..Diminished hunger was seen among subjects achieving the highest leptin levels. Our data provide new evidence of the important role of physiologic leptin regulation in the neuroendocrine response to acute caloric deprivation...
  52. ncbi request reprint Effects of testosterone administration in human immunodeficiency virus-infected women with low weight: a randomized placebo-controlled study
    Sara Dolan
    Neuroendocrine Unit and Program in Nutritional Metabolism, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Arch Intern Med 164:897-904. 2004
    ..Although androgen levels may often be reduced in such patients, the safety, tolerability, and efficacy of testosterone administration in this population remains unknown...
  53. ncbi request reprint Regional body composition in adolescents with anorexia nervosa and changes with weight recovery
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Am J Clin Nutr 77:1361-7. 2003
    ..Little is known about fat distribution in adolescents with AN, especially with weight recovery...
  54. ncbi request reprint Reduced bone density in HIV-infected women
    Sara E Dolan
    Neuroendocrine Unit and Program in Nutritional Metabolism, Massachusetts General Hospital, Boston 02114, USA
    AIDS 18:475-83. 2004
    ..Although bone density has been previously investigated in HIV-infected men, little is known regarding bone density in HIV-infected women...
  55. ncbi request reprint Dietary fat intake and relationship to serum lipid levels in HIV-infected patients with metabolic abnormalities in the HAART era
    Tisha Joy
    Program in Nutritional Metabolism, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    AIDS 21:1591-600. 2007
    ..To evaluate dietary intake and its relationship to lipid parameters in HIV-infected patients with metabolic abnormalities...
  56. ncbi request reprint Resistin levels in human immunodeficiency virus-infected patients with lipoatrophy decrease in response to rosiglitazone
    Daniel Kamin
    Program in Nutritional Metabolism, Massachusetts General Hospital, 55 Fruit Street, LON 207, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 90:3423-6. 2005
    ..Further investigation into the physiological role of this peroxisome proliferator-activated receptor-gamma-responsive adipocytokine in the metabolic abnormalities associated with HIV is warranted...
  57. ncbi request reprint Fat fractions and spectral T2 values in vertebral bone marrow in HIV- and non-HIV-infected men: a 1H spectroscopic imaging study
    Robert V Mulkern
    Department of Radiology, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Magn Reson Med 52:552-8. 2004
    ..Proton spectroscopic studies of vertebral marrow revealed differences between non-HIV- and HIV-infected men that may prove useful for studying the effects of this disease and/or antiretroviral agents on body composition...
  58. ncbi request reprint Increased adrenal androgen secretion with inhibition of 11beta-hydroxylase in HIV-infected women
    Polyxeni Koutkia
    Program in Nutritional Metabolism and Neuroendocrine Unit, Mass General Hospital, Harvard Medical School, 55 Fruit St, Boston, MA 02114, USA
    Am J Physiol Endocrinol Metab 290:E808-13. 2006
    ..Further studies are needed to assess the physiological effects of this strategy to increase anabolic hormone levels in severe stress, including detailed testing to rule out the potential risk of concomitant adrenal insufficiency...
  59. ncbi request reprint Effects of testosterone administration on growth hormone pulse dynamics in human immunodeficiency virus-infected women
    Sunita Schurgin
    Program in Nutritional Metabolism, Longfellow 207, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    J Clin Endocrinol Metab 89:3290-7. 2004
    ..The mechanism of this effect is unknown, but may involve a direct effect of testosterone on IGF-I, independent of changes in GH pulse dynamics...
  60. pmc Effects of long-term testosterone administration in HIV-infected women: a randomized, placebo-controlled trial
    Sara E Dolan Looby
    Program in Nutritional Metabolism, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    AIDS 23:951-9. 2009
    ..Androgen deficiency is common in HIV-infected women. We investigated the long-term effects of transdermal testosterone on body composition, bone mineral density, quality of life, and safety...
  61. ncbi request reprint Reduced testosterone levels in human immunodeficiency virus-infected women with weight loss and low weight
    Jeannie S Huang
    Neuroendocrine Unit and Program in Nutritional Metabolism, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Clin Infect Dis 36:499-506. 2003
    ..In conclusion, decreased androgen levels are common among HIV-infected women reporting significant weight loss, independent of exposure to antiretroviral medications...
  62. pmc Effects of a growth hormone-releasing hormone analog on endogenous GH pulsatility and insulin sensitivity in healthy men
    Takara L Stanley
    Massachusetts General Hospital Program in Nutritional Metabolism, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 96:150-8. 2011
    ..The objective of this study was to determine the effects of a novel GHRH (GHRH(1-44)) analog, tesamorelin, on endogenous GH pulsatility and insulin sensitivity in healthy men...
  63. pmc TNF-alpha antagonism with etanercept decreases glucose and increases the proportion of high molecular weight adiponectin in obese subjects with features of the metabolic syndrome
    Takara L Stanley
    Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 96:E146-50. 2011
    ....
  64. pmc Effects of a supervised home-based aerobic and progressive resistance training regimen in women infected with human immunodeficiency virus: a randomized trial
    Sara E Dolan
    Program in Nutritional Metabolism and Neuroendocrine Unit, Massachusetts General Hospital, Boston 02114, USA
    Arch Intern Med 166:1225-31. 2006
    ..Women infected with human immunodeficiency virus (HIV) increasingly demonstrate abnormalities in fat distribution and metabolism; however, the effects of a home-based exercise regimen in this group have not been investigated...
  65. ncbi request reprint HIV-associated lipodystrophy: pathogenesis, prognosis, treatment, and controversies
    Polyxeni Koutkia
    Massachusetts General Hospital Program in Nutritional Metabolism and Neuroendocrine Unit, Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, USA
    Annu Rev Med 55:303-17. 2004
    ..However, the long-term effects on cardiovascular disease have not yet been determined...
  66. ncbi request reprint Androgen deficiency and the role of testosterone administration in HIV-infected women
    Sara E Dolan
    Massachusetts General Hospital, Boston, MA, USA
    J Acquir Immune Defic Syndr 38:S48-9. 2005

Research Grants38

  1. Training Program in Nutrition and Metabolism
    Steven Grinspoon; Fiscal Year: 2007
    ..abstract_text> ..
  2. Consequences and Treatment of Growth Hormone Deficiency in the Metabolic Syndrome
    Steven Grinspoon; Fiscal Year: 2007
    ..Lay Description: This grant will study how commonly low GH level are seen and contribute to increased cardiac risk in patients with abdominal fat and whether increasing low GH levels will improve cardiac risk in this population. ..
  3. Androgen Effects in HIV-Infected Women
    Steven Grinspoon; Fiscal Year: 2007
    ..The studies outlined in this renewal constitute an important investigative initiative of a targeted, gender-specific therapy in this largely understudied population. ..
  4. Metabolic Syndrome, Lifestyle Modification and Resistance Training in HIV Disease
    Steven Grinspoon; Fiscal Year: 2007
    ..In addition, the grant will test whether changes in diet, exercise and metformin improves these risks and reduces atherosclerotic disease in the blood vessels. ..
  5. Inflammatory Mechanisms and Treatment Strategies for Atherosclerosis in HIV
    Steven Grinspoon; Fiscal Year: 2009
    ..In addition, the potential beneficial effects of a cholesterol-lowering medication on vascular inflammation and immune cells will be investigated in HIV patients with early asymptomatic atherosclerosis. (End of Abstract) ..
  6. Metabolic, and Cardiovascular Effects of GHRH in HIV Infected Patients
    Steven Grinspoon; Fiscal Year: 2009
    ..We will also investigate whether the use of a secretory factor that induces the body to makes its own GH, growth hormone releasing hormone, will improve cardiovascular risk endpoints, including abdominal fat, insulin, and carotid IMT. ..
  7. Consequences and Treatment of Growth Hormone Deficiency in the Metabolic Syndrome
    STEVEN KYLE GRINSPOON; Fiscal Year: 2010
    ..Lay Description: This grant will study how commonly low GH level are seen and contribute to increased cardiac risk in patients with abdominal fat and whether increasing low GH levels will improve cardiac risk in this population. ..
  8. Metabolic, and Cardiovascular Effects of GHRH in HIV Infected Patients
    STEVEN KYLE GRINSPOON; Fiscal Year: 2010
    ..We will also investigate whether the use of a secretory factor that induces the body to makes its own GH, growth hormone releasing hormone, will improve cardiovascular risk endpoints, including abdominal fat, insulin, and carotid IMT. ..
  9. Metabolic Syndrome, Lifestyle Modification and Resistance Training in HIV Disease
    STEVEN KYLE GRINSPOON; Fiscal Year: 2010
    ..In addition, the grant will test whether changes in diet, exercise and metformin improves these risks and reduces atherosclerotic disease in the blood vessels. ..
  10. Androgen Effects and Insulin Resistance in HIV Disease
    Steven Grinspoon; Fiscal Year: 2007
    ..abstract_text> ..
  11. Physiologic Growth Hormone Effects in HIV Lipodystrophy
    Steven Grinspoon; Fiscal Year: 2007
    ..The studies outlined in this grant proposal will investigate a novel approach to the treatment and management of critical metabolic abnormalities in patients with HIV lipodystrophy. ..
  12. AIDS WASTING IN WOMEN--ANABOLIC EFFECTS OF TESTOSTERONE
    Steven Grinspoon; Fiscal Year: 2002
    ..placebo therapy on body composition, functional status, and quality of life in a placebo-controlled study. ..
  13. MECHANISMS AND STRATEGIES FOR INSULIN RESISTANCE IN AIDS
    Steven Grinspoon; Fiscal Year: 2004
    ..The proposed studies represent a significant collaborative effort between clinical researchers, adipocyte biologists, epidemiologists and nutritional biochemists in satisfaction of the mandate of the RFA. ..
  14. Inflammatory Mechanisms and Treatment Strategies for Atherosclerosis in HIV
    STEVEN KYLE GRINSPOON; Fiscal Year: 2010
    ..In addition, the potential beneficial effects of a cholesterol-lowering medication on vascular inflammation and immune cells will be investigated in HIV patients with early asymptomatic atherosclerosis. (End of Abstract) ..