Linda Griffith

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. ncbi request reprint A microfabricated array bioreactor for perfused 3D liver culture
    Mark J Powers
    Division of Bioengineering and Environmental Health, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Biotechnol Bioeng 78:257-69. 2002
  2. pmc Perfused multiwell plate for 3D liver tissue engineering
    Karel Domansky
    Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA
    Lab Chip 10:51-8. 2010
  3. pmc Engineered bivalent ligands to bias ErbB receptor-mediated signaling and phenotypes
    Steven M Jay
    From the Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Biol Chem 286:27729-40. 2011
  4. pmc Growth factor regulation of proliferation and survival of multipotential stromal cells
    Melanie Rodrigues
    Department of Pathology, University of Pittsburgh, S713 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261 USA
    Stem Cell Res Ther 1:32. 2010
  5. ncbi request reprint In vitro organogenesis of liver tissue
    L G Griffith
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge 02139, USA
    Ann N Y Acad Sci 831:382-97. 1997
  6. ncbi request reprint Capturing complex 3D tissue physiology in vitro
    Linda G Griffith
    Biological Engineering Division, Mechanical Engineering Department and Biotech Pharma Engineering Center, Massachusetts Institute of Technology, 16 429, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    Nat Rev Mol Cell Biol 7:211-24. 2006
  7. ncbi request reprint Emerging design principles in biomaterials and scaffolds for tissue engineering
    Linda G Griffith
    Biological Engineering Division and Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Rm 66 466, Cambridge, MA 02139, USA
    Ann N Y Acad Sci 961:83-95. 2002
  8. ncbi request reprint Tissue engineering--current challenges and expanding opportunities
    Linda G Griffith
    Department of Chemical Engineering, Division of Bioengineering and Environmental Health, and Biotechnology Process Engineering Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 295:1009-14. 2002
  9. ncbi request reprint Microdistribution of substratum-bound ligands affects cell function: hepatocyte spreading on PEO-tethered galactose
    L G Griffith
    Department of Chemical Engineering and Center for Biomedical Engineering, Massachusetts Institute of Technology, Cambridge 02139, USA
    Biomaterials 19:979-86. 1998
  10. ncbi request reprint Advances in biomedical engineering
    L G Griffith
    Massachusetts Institute of Technology, 77 Mass Ave, Room 66 466, Cambridge, MA 02139, USA
    JAMA 285:556-61. 2001

Research Grants

Collaborators

  • Roger Kamm
  • George Muschler
  • Wendy S Koegler
  • Olivier Kocher
  • Melody A Swartz
  • DARRELL IRVINE
  • James L Sherley
  • Ryo Sudo
  • Harvey Lodish
  • Richard Hynes
  • Harry C Blair
  • Alan Wells
  • Manu O Platt
  • Walker Inman
  • Mark J Powers
  • Douglas A Lauffenburger
  • Ajit Dash
  • Ada Au
  • Karel Domansky
  • Kosuke Tsukamoto
  • Steven M Jay
  • Miles A Miller
  • Geeta Mehta
  • Melanie Rodrigues
  • Nicholas A Marcantonio
  • Cynthia A Boehm
  • Shawdee Eshghi
  • Anne M Mayes
  • William Kuhlman
  • Kenichi Tamama
  • Hsuan Shu Lee
  • Jill K Sherwood
  • Donna Beer Stolz
  • Kathryn E Wack
  • Monty Krieger
  • Lorenna Buck
  • Elma Kurtagic
  • Karen Jeng
  • Yadir Guerrero
  • Richard T Lee
  • Seymour de Picciotto
  • Layla Barkal
  • Marcia Moss
  • Carolyn L Treasure
  • Jessica F Hawkins
  • Luis M Alvarez
  • Andreas Herrlich
  • Edgar Sanchez
  • Robin N Prince
  • James Serdy
  • Courtney M Williams
  • Luis Alvarez
  • Matthew H M Lim
  • Martha Lesniewski
  • Joan Kelly
  • Catera L Wilder
  • Samantha Sevidal
  • Richard J Rozic
  • Steven R Tannenbaum
  • Keith Hoffmaster
  • R Scott Obach
  • Arian J Roman
  • Mariette G Vogelezang
  • Ikuo Taniguchi
  • Vivian H Fan
  • Joshua R Merok
  • Nicole L Hatch
  • James R Tunstead
  • Krishnanchali Panchalingam
  • Gracy G Crane
  • Dena M Janigian
  • Arpita Upadhyaya
  • Susan L Riley
  • Lee K Landeen
  • Mohammad R Kaazempur-Mofrad
  • Petra Kurzawski
  • Artemis Kalezi
  • Robert Palazzolo
  • Donald C Monkhouse
  • Anthony Ratcliffe
  • Carolyn S Baker
  • Matt Coates
  • Adam Capitano
  • Scott C Brown

Detail Information

Publications30

  1. ncbi request reprint A microfabricated array bioreactor for perfused 3D liver culture
    Mark J Powers
    Division of Bioengineering and Environmental Health, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Biotechnol Bioeng 78:257-69. 2002
    ..We also demonstrate repeated in situ imaging of tissue structure and function using two-photon microscopy...
  2. pmc Perfused multiwell plate for 3D liver tissue engineering
    Karel Domansky
    Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA
    Lab Chip 10:51-8. 2010
    ..After seven days of culture, tissue formed from cells seeded in the perfused multiwell reactor remained functionally viable as assessed by immunostaining for hepatocyte and liver sinusoidal endothelial cell (LSEC) phenotypic markers...
  3. pmc Engineered bivalent ligands to bias ErbB receptor-mediated signaling and phenotypes
    Steven M Jay
    From the Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Biol Chem 286:27729-40. 2011
    ..Hence, this new approach may have therapeutic relevance in ovarian, breast, lung, and other cancers in which HER3 has been implicated...
  4. pmc Growth factor regulation of proliferation and survival of multipotential stromal cells
    Melanie Rodrigues
    Department of Pathology, University of Pittsburgh, S713 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261 USA
    Stem Cell Res Ther 1:32. 2010
    ..The present review looks at the effect of and downstream signaling of various growth factors on proliferation and survival in MSCs...
  5. ncbi request reprint In vitro organogenesis of liver tissue
    L G Griffith
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge 02139, USA
    Ann N Y Acad Sci 831:382-97. 1997
    ....
  6. ncbi request reprint Capturing complex 3D tissue physiology in vitro
    Linda G Griffith
    Biological Engineering Division, Mechanical Engineering Department and Biotech Pharma Engineering Center, Massachusetts Institute of Technology, 16 429, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    Nat Rev Mol Cell Biol 7:211-24. 2006
    ..We emphasize applications that involve epithelial tissues for which 3D models could explain mechanisms of disease or aid in drug development...
  7. ncbi request reprint Emerging design principles in biomaterials and scaffolds for tissue engineering
    Linda G Griffith
    Biological Engineering Division and Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Rm 66 466, Cambridge, MA 02139, USA
    Ann N Y Acad Sci 961:83-95. 2002
    ..At the same time, new materials-processing methodologies are emerging to allow fabrication of these fragile materials into devices appropriate for delivery...
  8. ncbi request reprint Tissue engineering--current challenges and expanding opportunities
    Linda G Griffith
    Department of Chemical Engineering, Division of Bioengineering and Environmental Health, and Biotechnology Process Engineering Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 295:1009-14. 2002
    ....
  9. ncbi request reprint Microdistribution of substratum-bound ligands affects cell function: hepatocyte spreading on PEO-tethered galactose
    L G Griffith
    Department of Chemical Engineering and Center for Biomedical Engineering, Massachusetts Institute of Technology, Cambridge 02139, USA
    Biomaterials 19:979-86. 1998
    ..Our results suggest spreading results when monovalent ligands possess sufficient mobility to form effectively multivalent bonds with the receptor; that is, when the substratum-bound ligands to cluster in spatial microdomains...
  10. ncbi request reprint Advances in biomedical engineering
    L G Griffith
    Massachusetts Institute of Technology, 77 Mass Ave, Room 66 466, Cambridge, MA 02139, USA
    JAMA 285:556-61. 2001
    ..The emerging new field of bioengineering-engineering based in the science of molecular cell biology-will greatly expand the scope of biomedical engineering to tackle challenges in molecular and genomic medicine...
  11. pmc Proteolytic Activity Matrix Analysis (PrAMA) for simultaneous determination of multiple protease activities
    Miles A Miller
    Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Integr Biol (Camb) 3:422-38. 2011
    ..Moreover, our approach may extend to other families of proteases, such as caspases and cathepsins, that also can lack highly-specific substrates...
  12. ncbi request reprint Osteoblast response to PLGA tissue engineering scaffolds with PEO modified surface chemistries and demonstration of patterned cell response
    Wendy S Koegler
    Department of Chemical Engineering, MIT, Cambridge, MA 02139, USA
    Biomaterials 25:2819-30. 2004
    ..Patterned regions of low and high cell adhesion were demonstrated on scaffolds fabricated with 1 mm thick stripes of PEO and non-PEO regions...
  13. pmc Formation of osteogenic colonies on well-defined adhesion peptides by freshly isolated human marrow cells
    Ada Au
    Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Biomaterials 28:1847-61. 2007
    ..This study provides insights into integrin-mediated behaviors of CTPs and highlights differences between freshly isolated marrow and culture-expanded cells...
  14. pmc Challenges in using cultured primary rodent hepatocytes or cell lines to study hepatic HDL receptor SR-BI regulation by its cytoplasmic adaptor PDZK1
    Kosuke Tsukamoto
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
    PLoS ONE 8:e69725. 2013
    ..Such in vivo studies are time consuming and expensive, and cannot readily be used to explore many features of the underlying molecular and cellular mechanisms...
  15. ncbi request reprint Education for careers in tissue engineering and regenerative medicine
    Linda Griffith
    Biological Engineering and Mechanical Engineering, MIT, Cambridge, MA, USA
    Ann Biomed Eng 34:265-9. 2006
  16. pmc Multipathway kinase signatures of multipotent stromal cells are predictive for osteogenic differentiation: tissue-specific stem cells
    Manu O Platt
    Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Stem Cells 27:2804-14. 2009
    ....
  17. ncbi request reprint Functional behavior of primary rat liver cells in a three-dimensional perfused microarray bioreactor
    Mark J Powers
    Division of Biological Engineering, Biotechnology Process Engineering Center, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Tissue Eng 8:499-513. 2002
    ..The metabolic function data are supported by light microscopy images showing viable tissue structures, and electron microscopy images that reveal tight junctions, glycogen storage, and bile canaliculi...
  18. ncbi request reprint Clonal expansion of adult rat hepatic stem cell lines by suppression of asymmetric cell kinetics (SACK)
    Hsuan Shu Lee
    The Biological Engineering Division, Biotechnology Process Engineering Center, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Bldg 16, Room 743b, Cambridge, MA 02139, USA
    Biotechnol Bioeng 83:760-71. 2003
    ....
  19. pmc The influence of tethered epidermal growth factor on connective tissue progenitor colony formation
    Nicholas A Marcantonio
    Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Biomaterials 30:4629-38. 2009
    ..We found that tethered EGF, but not soluble EGF, increased the numbers of colonies formed regardless of adhesion background, and that tethered EGF did not impair early stages of osteogenic differentiation...
  20. pmc Transport-mediated angiogenesis in 3D epithelial coculture
    Ryo Sudo
    Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA 02139, USA
    FASEB J 23:2155-64. 2009
    ..The experimental approach described here is useful more generally for investigating microvascular networks within 3D engineered tissues with multiple cell types in vitro...
  21. pmc Synergistic effects of tethered growth factors and adhesion ligands on DNA synthesis and function of primary hepatocytes cultured on soft synthetic hydrogels
    Geeta Mehta
    Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Biomaterials 31:4657-71. 2010
    ..These modular matrices reveal new facets of hepatocellular biology in culture and may be more broadly useful in culture of other soft tissues...
  22. ncbi request reprint Carbon dioxide extraction of residual chloroform from biodegradable polymers
    Wendy S Koegler
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Biomed Mater Res 63:567-76. 2002
    ..The micro- and macroarchitectures of porous PLGA scaffolds created by particulate leaching were not significantly altered by CO(2) drying if the salt used to make the pores was not removed before drying...
  23. pmc Alpha4beta1 integrin and erythropoietin mediate temporally distinct steps in erythropoiesis: integrins in red cell development
    Shawdee Eshghi
    Division of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    J Cell Biol 177:871-80. 2007
    ....
  24. doi request reprint Liver tissue engineering in the evaluation of drug safety
    Ajit Dash
    Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Expert Opin Drug Metab Toxicol 5:1159-74. 2009
    ....
  25. pmc Sustained epidermal growth factor receptor levels and activation by tethered ligand binding enhances osteogenic differentiation of multi-potent marrow stromal cells
    Manu O Platt
    Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA
    J Cell Physiol 221:306-17. 2009
    ..Taken together, our results show that enhanced MSC osteogenic differentiation corresponds to a sustained combination of receptor expression and ligand presentation, both of which are maintained by tEGF...
  26. ncbi request reprint Interplay between PEO tether length and ligand spacing governs cell spreading on RGD-modified PMMA-g-PEO comb copolymers
    William Kuhlman
    Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Biomacromolecules 8:3206-13. 2007
    ..By contrast, when long peptide tethers were employed with short unsubstituted chains, cell attachment and spreading were comparable to that found on a monomodal brush of long chains at equivalent peptide density...
  27. pmc Simulations of cell-surface integrin binding to nanoscale-clustered adhesion ligands
    Darrell J Irvine
    Department of Materials Science and Engineering, Division of Bioengineering and Environmental Health, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Biophys J 82:120-32. 2002
    ....
  28. ncbi request reprint Engineering principles of clinical cell-based tissue engineering
    George F Muschler
    Departments of Orthopaedic Surgery and Biomedical Engineering A41, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    J Bone Joint Surg Am 86:1541-58. 2004
    ..This increasingly involves strategies that combine cells, matrices, inductive stimuli, and techniques that enhance the survival and performance of local or transplanted connective tissue progenitors...
  29. ncbi request reprint A three-dimensional osteochondral composite scaffold for articular cartilage repair
    Jill K Sherwood
    Therics, Inc, 115 Campus Drive, Princeton, NJ 08540, USA
    Biomaterials 23:4739-51. 2002
    ..The tensile strength of the bone region was similar in magnitude to fresh cancellous human bone, suggesting that these scaffolds have desirable mechanical properties for in vivo applications, including full joint replacement...
  30. ncbi request reprint Epidermal growth factor as a candidate for ex vivo expansion of bone marrow-derived mesenchymal stem cells
    Kenichi Tamama
    Department of Pathology, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, Pennsylvania 15261, USA
    Stem Cells 24:686-95. 2006
    ..These findings suggest that EGFR ligands could be used for ex vivo expansion and direction of BMMSCs...

Research Grants16

  1. BIOENGINEERED POLYMERS FOR PARSING CELL RESPONSES
    Linda Griffith; Fiscal Year: 1999
    ....
  2. Bioengineering Polymers for Parsing Cell Responses
    Linda G Griffith; Fiscal Year: 2010
    ..Lastly, trainees will be exchanged for extended periods to learn complementary techniques and approaches;this `sharing'of trainees has been used to great advantage. ..
  3. Perfused 3D Tissue Surrogates for Complex Cell-Cell Communication Systems
    Linda Griffith; Fiscal Year: 2009
    ....
  4. Bioengineering Polymers for Parsing Cell Responses
    Linda Griffith; Fiscal Year: 2009
    ..Lastly, trainees will be exchanged for extended periods to learn complementary techniques and approaches; this `sharing' of trainees has been used to great advantage. ..
  5. BIOENGINEERED POLYMERS FOR PARSING CELL RESPONSES
    Linda Griffith; Fiscal Year: 2007
    ..See instructions on Page Start with Principal investigator. List all other Name Linda Griffith, Ph.D. Anne Mayes, Ph.D. Alan Wells, M.D., D.M.S. 11...
  6. BIOENGINEERED POLYMERS FOR PARSING CELL RESPONSES
    Linda Griffith; Fiscal Year: 2007
    ..This project focuses on cells that generate the supporting stroma and vasculature. Such a repair promoting scaffold would be of value to patients with non-healing wounds, traumatic or otherwise, and tissue deficits. ..
  7. BIOENGINEERED POLYMERS FOR PARSING CELL RESPONSES
    Linda Griffith; Fiscal Year: 2005
    ..This project focuses on cells that generate the supporting stroma and vasculature. Such a repair promoting scaffold would be of value to patients with non-healing wounds, traumatic or otherwise, and tissue deficits. ..
  8. BIOENGINEERED POLYMERS FOR PARSING CELL RESPONSES
    Linda Griffith; Fiscal Year: 2004
    ..This project focuses on cells that generate the supporting stroma and vasculature. Such a repair promoting scaffold would be of value to patients with non-healing wounds, traumatic or otherwise, and tissue deficits. ..
  9. BIOENGINEERED POLYMERS FOR PARSING CELL RESPONSES
    Linda Griffith; Fiscal Year: 2002
    ....
  10. BIOENGINEERED POLYMERS FOR PARSING CELL RESPONSES
    Linda Griffith; Fiscal Year: 2001
    ....
  11. BIOENGINEERED POLYMERS FOR PARSING CELL RESPONSES
    Linda Griffith; Fiscal Year: 2000
    ....
  12. Perfused 3D Tissue Surrogates for Complex Cell-Cell Communication Systems
    Linda G Griffith; Fiscal Year: 2010
    ....
  13. BIOENGINEERED POLYMERS FOR PARSING CELL RESPONSES
    Linda Griffith; Fiscal Year: 2006
    ..This project focuses on cells that generate the supporting stroma and vasculature. Such a repair promoting scaffold would be of value to patients with non-healing wounds, traumatic or otherwise, and tissue deficits. ..
  14. ECI Conference on Engineering Cell Biology II - The Cell in Context
    Linda Griffith; Fiscal Year: 2007
    ..This conference will also emphasize translation of basic research into industry application in tissue engineering and drug development. ..