Steven Greenberg

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi Detection of isolated cerebrovascular beta-amyloid with Pittsburgh compound B
    Steven M Greenberg
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Ann Neurol 64:587-91. 2008
  2. ncbi Cerebral microbleeds: a guide to detection and interpretation
    Steven M Greenberg
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Lancet Neurol 8:165-74. 2009
  3. ncbi Amyloid angiopathy-related vascular cognitive impairment
    Steven M Greenberg
    Neurology Clinical Trials Unit and Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Mass 02114, USA
    Stroke 35:2616-9. 2004
  4. ncbi Microbleeds versus macrobleeds: evidence for distinct entities
    Steven M Greenberg
    MGH Stroke Research Center, Harvard Medical School, Boston, MA 02114, USA
    Stroke 40:2382-6. 2009
  5. ncbi Myeloid dendritic cells in inclusion-body myositis and polymyositis
    Steven A Greenberg
    Department of Neurology, Division of Neuromuscular Disease, Brigham and Women s Hospital, 75 Francis Street, and Harvard Medical School, Boston, Massachusetts 02115, USA
    Muscle Nerve 35:17-23. 2007
  6. ncbi A phase 2 study of tramiprosate for cerebral amyloid angiopathy
    Steven M Greenberg
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Alzheimer Dis Assoc Disord 20:269-74. 2006
  7. ncbi Human plasmacytoid dendritic cell accumulation amplifies their type 1 interferon production
    Anne P Liao
    Department of Neurology, Division of Neuromuscular Disease, Brigham and Women s Hospital, Boston, MA, USA
    Clin Immunol 136:130-8. 2010
  8. ncbi Type I interferon-inducible gene expression in blood is present and reflects disease activity in dermatomyositis and polymyositis
    Ronan J Walsh
    Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Arthritis Rheum 56:3784-92. 2007
  9. ncbi Permissive environment for B-cell maturation in myositis muscle in the absence of B-cell follicles
    Mohammad Salajegheh
    Department of Neurology, Division of Neuromuscular Disease, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, Massachusetts 02115, USA
    Muscle Nerve 42:576-83. 2010
  10. ncbi Interferon-stimulated gene 15 (ISG15) conjugates proteins in dermatomyositis muscle with perifascicular atrophy
    Mohammad Salajegheh
    Children s Hospital Informatics Program, Division of Neuromuscular Disease, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Ann Neurol 67:53-63. 2010

Research Grants

  1. Early Detection of Cerebral Amyloid Angiopathy
    Steven M Greenberg; Fiscal Year: 2010
  2. Vascular Dysfunction in Cerebral Amyloid Angiopathy
    Steven Greenberg; Fiscal Year: 2009
  3. Clinical, Radiographic, and Genetic Associations in Cerebral Amyloid Angiopathy
    Steven Greenberg; Fiscal Year: 2007
  4. Genetic Risks for Medication-Related Hemorrhagic Stroke
    Steven Greenberg; Fiscal Year: 2007
  5. Vascular Dysfunction in Cerebral Amyloid Angiopathy
    Steven Greenberg; Fiscal Year: 2007
  6. NC-758 for Prevention of Recurrent Cerebral Hemorrhage
    Steven Greenberg; Fiscal Year: 2005
  7. Spatial and temporal progression of amyloid angiopathy
    Steven Greenberg; Fiscal Year: 2003
  8. Vascular Dysfunction in Cerebral Amyloid Angiopathy
    Steven M Greenberg; Fiscal Year: 2010

Detail Information

Publications46

  1. ncbi Detection of isolated cerebrovascular beta-amyloid with Pittsburgh compound B
    Steven M Greenberg
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Ann Neurol 64:587-91. 2008
    ..These results offer compelling evidence that Pittsburgh Compound B positron emission tomography can noninvasively detect isolated cerebral amyloid angiopathy before overt signs of tissue damage such as hemorrhage or white matter lesions...
  2. ncbi Cerebral microbleeds: a guide to detection and interpretation
    Steven M Greenberg
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Lancet Neurol 8:165-74. 2009
    ..We propose a procedural guide for identification of CMBs and suggest possible future approaches for elucidating the role of these common lesions as markers for, and contributors to, small-vessel brain disease...
  3. ncbi Amyloid angiopathy-related vascular cognitive impairment
    Steven M Greenberg
    Neurology Clinical Trials Unit and Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Mass 02114, USA
    Stroke 35:2616-9. 2004
    ..These data highlight the importance of elucidating the effects of vascular amyloid on cerebrovascular function and of developing therapeutic strategies for this potentially widespread form of microvascular cognitive impairment...
  4. ncbi Microbleeds versus macrobleeds: evidence for distinct entities
    Steven M Greenberg
    MGH Stroke Research Center, Harvard Medical School, Boston, MA 02114, USA
    Stroke 40:2382-6. 2009
    ..It is unclear whether microbleeds and macrobleeds represent arbitrary categories within a single continuum versus truly distinct events with separate pathophysiologies...
  5. ncbi Myeloid dendritic cells in inclusion-body myositis and polymyositis
    Steven A Greenberg
    Department of Neurology, Division of Neuromuscular Disease, Brigham and Women s Hospital, 75 Francis Street, and Harvard Medical School, Boston, Massachusetts 02115, USA
    Muscle Nerve 35:17-23. 2007
    ..The stellate morphology of myeloid DCs in dense collections of cells that included T cells suggests local intramuscular antigen presentation in IBM and PM...
  6. ncbi A phase 2 study of tramiprosate for cerebral amyloid angiopathy
    Steven M Greenberg
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Alzheimer Dis Assoc Disord 20:269-74. 2006
    ..Tramiprosate (3-amino-1-propanesulfonic acid) is a candidate molecule shown in preclinical studies to reduce CAA in a transgenic mouse model...
  7. ncbi Human plasmacytoid dendritic cell accumulation amplifies their type 1 interferon production
    Anne P Liao
    Department of Neurology, Division of Neuromuscular Disease, Brigham and Women s Hospital, Boston, MA, USA
    Clin Immunol 136:130-8. 2010
    ..The role of the IFNAR-dependent mechanism of interferon production by human pDCs is greater than previously suggested. IFNAR blockade has potential for diminishing type 1 interferon production by all human cells...
  8. ncbi Type I interferon-inducible gene expression in blood is present and reflects disease activity in dermatomyositis and polymyositis
    Ronan J Walsh
    Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Arthritis Rheum 56:3784-92. 2007
    ....
  9. ncbi Permissive environment for B-cell maturation in myositis muscle in the absence of B-cell follicles
    Mohammad Salajegheh
    Department of Neurology, Division of Neuromuscular Disease, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, Massachusetts 02115, USA
    Muscle Nerve 42:576-83. 2010
    ..An atypical lymphoid histology, lacking concentrated collections of germinal-center-like B-cell follicles, is capable of antigen-stimulated clonal maturation of antibody-producing plasma cells...
  10. ncbi Interferon-stimulated gene 15 (ISG15) conjugates proteins in dermatomyositis muscle with perifascicular atrophy
    Mohammad Salajegheh
    Children s Hospital Informatics Program, Division of Neuromuscular Disease, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Ann Neurol 67:53-63. 2010
    ..We investigated interferon-stimulated gene 15 (ISG15), a poorly understood ubiquitin-like modifier, and its enzymatic pathway in dermatomyositis (DM), an autoimmune disease primarily involving muscle and skin...
  11. ncbi Proposed immunologic models of the inflammatory myopathies and potential therapeutic implications
    Steven A Greenberg
    Department of Neurology, Brigham and Womens Hospital, Harvard Medical School, Boston, MA 02115, USA
    Neurology 69:2008-19. 2007
    ..The presence of these immune cells and processes suggests revisions in models of the pathogenesis of the inflammatory myopathies and provides rationales for future therapeutic approaches...
  12. ncbi A gene expression approach to study perturbed pathways in myositis
    Steven A Greenberg
    Division of Neuromuscular Disease, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Opin Rheumatol 19:536-41. 2007
    ..To review new insights into the disease mechanisms of dermatomyositis, inclusion body myositis, and polymyositis gained from large-scale microarray gene expression studies of patient tissue samples...
  13. ncbi Inflammatory myopathies: evaluation and management
    Steven A Greenberg
    Department of Neurology, Brigham and Women s Hospital, Department of Neurology, Division of Neuromuscular Disease, Brigham and Women sHospital, and Harvard Medical School, Boston, MA 02115, USA
    Semin Neurol 28:241-9. 2008
    ..Osteoporosis and opportunistic infections pose a significant risk during treatment of patients. This review discusses the clinical manifestations, pathology, and treatment approaches for the inflammatory myopathies...
  14. ncbi Inclusion body myositis: review of recent literature
    Steven A Greenberg
    Department of Neurology, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Curr Neurol Neurosci Rep 9:83-9. 2009
    ..In particular, it addresses limitations in the beta-amyloid-mediated theory of IBM myofiber injury, flawed rationales of animal models of this disease, and recent reports regarding treatment...
  15. ncbi Sarcoplasmic redistribution of nuclear TDP-43 in inclusion body myositis
    Mohammad Salajegheh
    Department of Neurology, Division of Neuromuscular Disease, Brigham and Women s Hospital, and Harvard Medical School, 75 Francis Street, Boston, Massachusetts 02115, USA
    Muscle Nerve 40:19-31. 2009
    ..TDP-43 could be one of many nucleic acid binding proteins that are abnormally present in IBM sarcoplasm. They could potentially interfere with the normal function of extranuclear RNAs that maintain myofiber protein production...
  16. ncbi How citation distortions create unfounded authority: analysis of a citation network
    Steven A Greenberg
    Children s Hospital Informatics Program and Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    BMJ 339:b2680. 2009
    ..To understand belief in a specific scientific claim by studying the pattern of citations among papers stating it...
  17. ncbi Pearls: neuromuscular disorders
    Steven A Greenberg
    Harvard Medical School, Department of Neurology, Brigham and Women s Hospital, Children s Hospital Informatics Program, Boston, Massachusetts, USA
    Semin Neurol 30:28-34. 2010
    ..The presentation of Lambert-Eaton myasthenic syndrome as a nonfluctuating subacute myopathy is emphasized. Patterns of weakness in inclusion body myositis and facioscapulohumeral muscular dystrophy are illustrated...
  18. ncbi Dermatomyositis-like muscle pathology in patients with chronic graft-versus-host disease
    Jeffrey A Allen
    Department of Neurology, Division of Neuromuscular Disease, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, Massachusetts 02115, USA
    Muscle Nerve 40:643-7. 2009
    ..In each case, perifascicular atrophy, the pathognomonic histologic feature of dermatomyositis (DM), was observed...
  19. ncbi Inflammatory myopathies: disease mechanisms
    Steven A Greenberg
    Children s Hospital Informatics Program, Department of Neurology, Division of Neuromuscular Disease, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Opin Neurol 22:516-23. 2009
    ..Recent developments pertaining to disease mechanisms in the inflammatory myopathies are discussed, emphasizing those areas that are of particular interest to me...
  20. ncbi Nuclear localization of valosin-containing protein in normal muscle and muscle affected by inclusion-body myositis
    Steven A Greenberg
    Department of Neurology, Division of Neuromuscular Disease, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02115, USA
    Muscle Nerve 36:447-54. 2007
    ..These findings suggest that impairment in the nuclear function of VCP might contribute to the muscle pathology occurring in IBMPFD...
  21. ncbi Theories of the pathogenesis of inclusion body myositis
    Steven A Greenberg
    Department of Neurology, Division of Neuromuscular Disease, Brigham and Women s Hospital, and Children s Hospital Informatics Program, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Curr Rheumatol Rep 12:221-8. 2010
    ..Current published animal models do not represent the disease. Future studies need to consider the critical role of biomarkers and methodologic issues in their discovery...
  22. ncbi P-ANCA vasculitic neuropathy with 12-year latency between onset of neuropathy and systemic symptoms
    Steven A Greenberg
    Division of Neuromuscular Disease, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, USA
    BMC Neurol 2:10. 2002
    ..Vasculitic neuropathies, multifocal forms of chronic inflammatory demyelinating polyneuropathy, multifocal motor neuropathies, and asymmetric lower motor neuron disorders are important considerations...
  23. ncbi The history of dermatome mapping
    Steven A Greenberg
    Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Arch Neurol 60:126-31. 2003
    ....
  24. ncbi Acquired rippling muscle disease with myasthenia gravis
    Steven A Greenberg
    Department of Neurology, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, Massachusetts 02115, USA
    Muscle Nerve 29:143-6. 2004
    ..This report emphasizes the clinical manifestations of RMD in association with myasthenia gravis (RMD-MG), and its distinctive features, in this and previously reported patients...
  25. ncbi Molecular classification of nemaline myopathies: "nontyping" specimens exhibit unique patterns of gene expression
    Despina Sanoudou
    Genomics Program and Divisison of Genetics, Children's Hospital Boston, and Harvard Medical School, MA 20115, USA
    Neurobiol Dis 15:590-600. 2004
    ..Determination of the specific molecular differences in NM subgroups may eventually lead to improved prognostic determinations and treatment of these patients...
  26. ncbi Uncertainties in the pathogenesis of adult dermatomyositis
    Steven A Greenberg
    Brigham and Women s Hospital, Department of Neurology, Division of Neuromuscular Disease, Harvard Medical School, Boston, USA
    Curr Opin Neurol 17:359-64. 2004
    ....
  27. ncbi Interferon β is associated with type 1 interferon-inducible gene expression in dermatomyositis
    Anne P Liao
    Department of Neurology, Division of Neuromuscular Disease, Brigham and Women s Hospital and Children s Hospital Informatics Program, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Ann Rheum Dis 70:831-6. 2011
    ..To determine whether type 1 interferon (IFN) proteins in blood are associated with downstream type 1 IFN-inducible gene expression in blood from patients with myositis...
  28. ncbi Zinc transmetallation and gadolinium retention after MR imaging: case report
    Steven A Greenberg
    Department of Neurology, Brigham and Women s Hospital, Children s Hospital Informatics Program, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
    Radiology 257:670-3. 2010
    ..6 μg/d). This single case report suggests that patients with elevated zinc exposure may be at increased risk of gadolinium retention...
  29. ncbi Molecular diagnosis of inheritable neuromuscular disorders. Part I: Genetic determinants of inherited disease and their laboratory detection
    Steven A Greenberg
    Department of Neurology, Division of Neuromuscular Disease, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, Massachusetts 02115, USA
    Muscle Nerve 31:418-30. 2005
    ..The second part discusses the applicability of these tests to the range of neuromuscular disorders...
  30. ncbi Molecular diagnosis of inheritable neuromuscular disorders. Part II: Application of genetic testing in neuromuscular disease
    Steven A Greenberg
    Department of Neurology, Division of Neuromuscular Disease, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, Massachusetts 02115, USA
    Muscle Nerve 31:431-51. 2005
    ..The role of potential multiple genetic influences on the development of acquired neuromuscular diseases is an increasingly active area of research...
  31. ncbi Interferon-alpha/beta-mediated innate immune mechanisms in dermatomyositis
    Steven A Greenberg
    Department of Neurology, Division of Neuromuscular Disease, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Ann Neurol 57:664-78. 2005
    ....
  32. ncbi Nuclear membrane proteins are present within rimmed vacuoles in inclusion-body myositis
    Steven A Greenberg
    Department of Neurology, Division of Neuromuscular Disease, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Muscle Nerve 34:406-16. 2006
    ....
  33. ncbi Gene expression comparison of biopsies from Duchenne muscular dystrophy (DMD) and normal skeletal muscle
    Judith N Haslett
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 99:15000-5. 2002
    ....
  34. ncbi Dermatomyositis and type 1 interferons
    Steven A Greenberg
    Department of Neurology, Division of Neuromuscular Disease, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Curr Rheumatol Rep 12:198-203. 2010
    ....
  35. ncbi Understanding belief using citation networks
    Steven A Greenberg
    Department of Neurology, Division of Neuromuscular Disease, Brigham and Women s Hospital, Boston, MA, USA
    J Eval Clin Pract 17:389-93. 2011
    ..Here, I discuss further the methodological approaches to studying published scientific belief systems and identifying citation distortions...
  36. ncbi Immune-mediated necrotizing myopathy associated with statins
    Phyllis Grable-Esposito
    Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Muscle Nerve 41:185-90. 2010
    ....
  37. ncbi Nature of "Tau" immunoreactivity in normal myonuclei and inclusion body myositis
    Mohammad Salajegheh
    Department of Neurology, Division of Neuromuscular Disease, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Muscle Nerve 40:520-8. 2009
    ..Normal myonuclei contain neurofilament H or other unidentified 200 kDa proteins with similar phosphorylated motifs accounting for SMI-31 immunoreactivity...
  38. ncbi Microarray analysis of human nervous system gene expression in neurological disease
    Steven A Greenberg
    Department of Neurology, Division of Neuromuscular Disease, Brigham and Women's Hospital, Children's Hospital Informatics Program, Harvard Medical School, Boston, Massachusetts 02115, USA
    Int Rev Neurobiol 60:135-51. 2004
  39. ncbi Expression profiling reveals altered satellite cell numbers and glycolytic enzyme transcription in nemaline myopathy muscle
    Despina Sanoudou
    Division of Genetics, Children's Hospital, and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 100:4666-71. 2003
    ..This comprehensive study of downstream molecular consequences of NM gene mutations provides insights in the cellular events leading to the NM phenotype...
  40. ncbi Fast-twitch sarcomeric and glycolytic enzyme protein loss in inclusion body myositis
    Kenneth C Parker
    Harvard Partners Center for Genetics and Genomics, Proteomics Core, Harvard Medical School, Boston, Massachusetts USA
    Muscle Nerve 39:739-53. 2009
    ..Although muscle atrophy has long been recognized in IBM, these studies are the first to report specific proteins which are reduced in quantity in IBM muscle...
  41. ncbi Statin use following intracerebral hemorrhage: a decision analysis
    M Brandon Westover
    Massachusetts General Hospital Stroke Research Center, 175 Cambridge Street, Boston, MA 02114, USA
    Arch Neurol 68:573-9. 2011
    ..For patients with baseline elevated risk of ICH, it is not known whether this potential adverse effect offsets the cardiovascular and cerebrovascular benefits...
  42. ncbi A local antigen-driven humoral response is present in the inflammatory myopathies
    Elizabeth M Bradshaw
    Department of Neurology, Laboratory of Molecular Immunology, Center for Neurologic Diseases and Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 178:547-56. 2007
    ..These findings highlight the need for a revision of the current paradigm of exclusively T cell-mediated intramuscular Ag-specific autoimmunity in inclusion body myositis and polymyositis...
  43. ncbi Discovering statistically significant pathways in expression profiling studies
    Lu Tian
    Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, 680 North Lake Shore Drive, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 102:13544-9. 2005
    ..These predictions have been subsequently corroborated by immunohistochemistry...
  44. ncbi Pushing the genetic frontier with facioscapulohumeral muscular dystrophy
    Steven A Greenberg
    Neurology 68:544-5. 2007
  45. ncbi A neurological and hematological syndrome associated with zinc excess and copper deficiency
    Steven A Greenberg
    J Neurol 251:111-4. 2004
  46. ncbi CrossChip: a system supporting comparative analysis of different generations of Affymetrix arrays
    Sek Won Kong
    Bauer Center for Genomics Research, Harvard University, Cambridge, MA, USA
    Bioinformatics 21:2116-7. 2005
    ..Our website supports a within-species comparison for human and mouse GeneChip arrays. AVAILABILITY: http://www.crosschip.org..

Research Grants19

  1. Early Detection of Cerebral Amyloid Angiopathy
    Steven M Greenberg; Fiscal Year: 2010
    ....
  2. Vascular Dysfunction in Cerebral Amyloid Angiopathy
    Steven Greenberg; Fiscal Year: 2009
    ..Successful completion of this study will represent a key step towards developing diagnostic markers, outcome markers, and candidate treatments for future trials aimed at preventing CAA-related cognitive impairment. ..
  3. Clinical, Radiographic, and Genetic Associations in Cerebral Amyloid Angiopathy
    Steven Greenberg; Fiscal Year: 2007
    ....
  4. Genetic Risks for Medication-Related Hemorrhagic Stroke
    Steven Greenberg; Fiscal Year: 2007
    ..This proposal is thus likely to form the foundation of a powerful, open-ended search for a panel of genetic tests to determine an individual's risk for Warfarin-related ICH. ..
  5. Vascular Dysfunction in Cerebral Amyloid Angiopathy
    Steven Greenberg; Fiscal Year: 2007
    ..Successful completion of this study will represent a key step towards developing diagnostic markers, outcome markers, and candidate treatments for future trials aimed at preventing CAA-related cognitive impairment. ..
  6. NC-758 for Prevention of Recurrent Cerebral Hemorrhage
    Steven Greenberg; Fiscal Year: 2005
    ..In addition to testing a promising agent for CAA, the proposed study will generate the organization and pilot data to serve as a springboard for future trials of emerging anti-amyloid treatments. ..
  7. Spatial and temporal progression of amyloid angiopathy
    Steven Greenberg; Fiscal Year: 2003
    ..abstract_text> ..
  8. Vascular Dysfunction in Cerebral Amyloid Angiopathy
    Steven M Greenberg; Fiscal Year: 2010
    ..These studies will create a strong foundation for starting treatment trials aimed at preventing this major threat to our aging population. ..