S A Greenberg

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi Human plasmacytoid dendritic cell accumulation amplifies their type 1 interferon production
    Anne P Liao
    Department of Neurology, Division of Neuromuscular Disease, Brigham and Women s Hospital, Boston, MA, USA
    Clin Immunol 136:130-8. 2010
  2. ncbi Pathogenesis and therapy of inclusion body myositis
    Steven A Greenberg
    Division of Neuromuscular Disease, Department of Neurology, Brigham and Women s Hospital, and Children s Hospital Informatics Program Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Opin Neurol 25:630-9. 2012
  3. ncbi Type 1 interferons and myositis
    Steven A Greenberg
    Department of Neurology, Division of Neuromuscular Disease, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Arthritis Res Ther 12:S4. 2010
  4. ncbi Relationship between disease activity and type 1 interferon- and other cytokine-inducible gene expression in blood in dermatomyositis and polymyositis
    S A Greenberg
    Department of Neurology, Division of Neuromuscular Disease, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Genes Immun 13:207-13. 2012
  5. ncbi Combining gene expression data from different generations of oligonucleotide arrays
    Kyu Baek Hwang
    School of Computer Science and Engineering, Seoul National University, Seoul 151 742, Korea
    BMC Bioinformatics 5:159. 2004
  6. ncbi Etiology of limb girdle muscular dystrophy 1D/1E determined by laser capture microdissection proteomics
    Steven A Greenberg
    Department of Neurology, Division of Neuromuscular Disease, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Ann Neurol 71:141-5. 2012
  7. ncbi Inflammatory myopathies: evaluation and management
    Steven A Greenberg
    Department of Neurology, Brigham and Women s Hospital, Department of Neurology, Division of Neuromuscular Disease, Brigham and Women sHospital, and Harvard Medical School, Boston, MA 02115, USA
    Semin Neurol 28:241-9. 2008
  8. ncbi Proposed immunologic models of the inflammatory myopathies and potential therapeutic implications
    Steven A Greenberg
    Department of Neurology, Brigham and Womens Hospital, Harvard Medical School, Boston, MA 02115, USA
    Neurology 69:2008-19. 2007
  9. ncbi A gene expression approach to study perturbed pathways in myositis
    Steven A Greenberg
    Division of Neuromuscular Disease, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Opin Rheumatol 19:536-41. 2007
  10. ncbi Nuclear localization of valosin-containing protein in normal muscle and muscle affected by inclusion-body myositis
    Steven A Greenberg
    Department of Neurology, Division of Neuromuscular Disease, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02115, USA
    Muscle Nerve 36:447-54. 2007

Research Grants

  1. Gene Expression in Inflammatory Myopathies
    Steven Greenberg; Fiscal Year: 2005

Detail Information

Publications52

  1. ncbi Human plasmacytoid dendritic cell accumulation amplifies their type 1 interferon production
    Anne P Liao
    Department of Neurology, Division of Neuromuscular Disease, Brigham and Women s Hospital, Boston, MA, USA
    Clin Immunol 136:130-8. 2010
    ..The role of the IFNAR-dependent mechanism of interferon production by human pDCs is greater than previously suggested. IFNAR blockade has potential for diminishing type 1 interferon production by all human cells...
  2. ncbi Pathogenesis and therapy of inclusion body myositis
    Steven A Greenberg
    Division of Neuromuscular Disease, Department of Neurology, Brigham and Women s Hospital, and Children s Hospital Informatics Program Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Opin Neurol 25:630-9. 2012
    ..No reliable effective therapy currently exists for IBM. This review provides an update of current issues in the pathogenesis and therapy of IBM...
  3. ncbi Type 1 interferons and myositis
    Steven A Greenberg
    Department of Neurology, Division of Neuromuscular Disease, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Arthritis Res Ther 12:S4. 2010
    ..Therapeutic development for blockade of IFNα is in progress aided by the identification of blood genomic biomarkers...
  4. ncbi Relationship between disease activity and type 1 interferon- and other cytokine-inducible gene expression in blood in dermatomyositis and polymyositis
    S A Greenberg
    Department of Neurology, Division of Neuromuscular Disease, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Genes Immun 13:207-13. 2012
    ..The type 1 IFN-inducible gene transcripts in the blood have potential utility for monitoring disease activity in patients with DM or PM...
  5. ncbi Combining gene expression data from different generations of oligonucleotide arrays
    Kyu Baek Hwang
    School of Computer Science and Engineering, Seoul National University, Seoul 151 742, Korea
    BMC Bioinformatics 5:159. 2004
    ..However, as we discover in this work, continual changes in genomic sequence annotations and probe design criteria make it difficult to compare gene expression data even from different generations of the same microarray platform...
  6. ncbi Etiology of limb girdle muscular dystrophy 1D/1E determined by laser capture microdissection proteomics
    Steven A Greenberg
    Department of Neurology, Division of Neuromuscular Disease, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Ann Neurol 71:141-5. 2012
    ..Sequencing in this patient and family members identified the genetic basis of the previously reported 6q23 linked LGMD1D/1E to be due to an intron splice donor site mutation (IVS3+3A>G) of the desmin gene located on chromosome 2q35...
  7. ncbi Inflammatory myopathies: evaluation and management
    Steven A Greenberg
    Department of Neurology, Brigham and Women s Hospital, Department of Neurology, Division of Neuromuscular Disease, Brigham and Women sHospital, and Harvard Medical School, Boston, MA 02115, USA
    Semin Neurol 28:241-9. 2008
    ..Osteoporosis and opportunistic infections pose a significant risk during treatment of patients. This review discusses the clinical manifestations, pathology, and treatment approaches for the inflammatory myopathies...
  8. ncbi Proposed immunologic models of the inflammatory myopathies and potential therapeutic implications
    Steven A Greenberg
    Department of Neurology, Brigham and Womens Hospital, Harvard Medical School, Boston, MA 02115, USA
    Neurology 69:2008-19. 2007
    ..The presence of these immune cells and processes suggests revisions in models of the pathogenesis of the inflammatory myopathies and provides rationales for future therapeutic approaches...
  9. ncbi A gene expression approach to study perturbed pathways in myositis
    Steven A Greenberg
    Division of Neuromuscular Disease, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Opin Rheumatol 19:536-41. 2007
    ..To review new insights into the disease mechanisms of dermatomyositis, inclusion body myositis, and polymyositis gained from large-scale microarray gene expression studies of patient tissue samples...
  10. ncbi Nuclear localization of valosin-containing protein in normal muscle and muscle affected by inclusion-body myositis
    Steven A Greenberg
    Department of Neurology, Division of Neuromuscular Disease, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02115, USA
    Muscle Nerve 36:447-54. 2007
    ..These findings suggest that impairment in the nuclear function of VCP might contribute to the muscle pathology occurring in IBMPFD...
  11. ncbi Nuclear membrane proteins are present within rimmed vacuoles in inclusion-body myositis
    Steven A Greenberg
    Department of Neurology, Division of Neuromuscular Disease, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Muscle Nerve 34:406-16. 2006
    ....
  12. ncbi Inclusion body myositis: review of recent literature
    Steven A Greenberg
    Department of Neurology, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Curr Neurol Neurosci Rep 9:83-9. 2009
    ..In particular, it addresses limitations in the beta-amyloid-mediated theory of IBM myofiber injury, flawed rationales of animal models of this disease, and recent reports regarding treatment...
  13. ncbi How citation distortions create unfounded authority: analysis of a citation network
    Steven A Greenberg
    Children s Hospital Informatics Program and Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    BMJ 339:b2680. 2009
    ..To understand belief in a specific scientific claim by studying the pattern of citations among papers stating it...
  14. ncbi Inflammatory myopathies: disease mechanisms
    Steven A Greenberg
    Children s Hospital Informatics Program, Department of Neurology, Division of Neuromuscular Disease, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Opin Neurol 22:516-23. 2009
    ..Recent developments pertaining to disease mechanisms in the inflammatory myopathies are discussed, emphasizing those areas that are of particular interest to me...
  15. ncbi Pearls: neuromuscular disorders
    Steven A Greenberg
    Harvard Medical School, Department of Neurology, Brigham and Women s Hospital, Children s Hospital Informatics Program, Boston, Massachusetts, USA
    Semin Neurol 30:28-34. 2010
    ..The presentation of Lambert-Eaton myasthenic syndrome as a nonfluctuating subacute myopathy is emphasized. Patterns of weakness in inclusion body myositis and facioscapulohumeral muscular dystrophy are illustrated...
  16. ncbi Theories of the pathogenesis of inclusion body myositis
    Steven A Greenberg
    Department of Neurology, Division of Neuromuscular Disease, Brigham and Women s Hospital, and Children s Hospital Informatics Program, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Curr Rheumatol Rep 12:221-8. 2010
    ..Current published animal models do not represent the disease. Future studies need to consider the critical role of biomarkers and methodologic issues in their discovery...
  17. ncbi Dermatomyositis and type 1 interferons
    Steven A Greenberg
    Department of Neurology, Division of Neuromuscular Disease, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Curr Rheumatol Rep 12:198-203. 2010
    ....
  18. ncbi Understanding belief using citation networks
    Steven A Greenberg
    Department of Neurology, Division of Neuromuscular Disease, Brigham and Women s Hospital, Boston, MA, USA
    J Eval Clin Pract 17:389-93. 2011
    ..Here, I discuss further the methodological approaches to studying published scientific belief systems and identifying citation distortions...
  19. ncbi Inclusion body myositis
    Steven A Greenberg
    Division of Neuromuscular Disease, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Curr Opin Rheumatol 23:574-8. 2011
    ..Sporadic inclusion body myositis (sIBM) is a poorly understood immune and degenerative disease of skeletal muscle. Here, current opinion of the nature of this disease is summarized...
  20. ncbi Plasma cells in muscle in inclusion body myositis and polymyositis
    S A Greenberg
    Division of Neuromuscular Disease, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Neurology 65:1782-7. 2005
    ....
  21. ncbi Acquired rippling muscle disease with myasthenia gravis
    Steven A Greenberg
    Department of Neurology, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, Massachusetts 02115, USA
    Muscle Nerve 29:143-6. 2004
    ..This report emphasizes the clinical manifestations of RMD in association with myasthenia gravis (RMD-MG), and its distinctive features, in this and previously reported patients...
  22. ncbi P-ANCA vasculitic neuropathy with 12-year latency between onset of neuropathy and systemic symptoms
    Steven A Greenberg
    Division of Neuromuscular Disease, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, USA
    BMC Neurol 2:10. 2002
    ..Vasculitic neuropathies, multifocal forms of chronic inflammatory demyelinating polyneuropathy, multifocal motor neuropathies, and asymmetric lower motor neuron disorders are important considerations...
  23. ncbi Henry Head (1861-1940)
    S A Greenberg
    Department of Neurology, Brigham and Women's Hospital Harvard Medical School, 02115, Boston, MA, USA
    J Neurol 251:1158-9. 2004
  24. ncbi Zinc transmetallation and gadolinium retention after MR imaging: case report
    Steven A Greenberg
    Department of Neurology, Brigham and Women s Hospital, Children s Hospital Informatics Program, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
    Radiology 257:670-3. 2010
    ..6 μg/d). This single case report suggests that patients with elevated zinc exposure may be at increased risk of gadolinium retention...
  25. ncbi Uncertainties in the pathogenesis of adult dermatomyositis
    Steven A Greenberg
    Brigham and Women s Hospital, Department of Neurology, Division of Neuromuscular Disease, Harvard Medical School, Boston, USA
    Curr Opin Neurol 17:359-64. 2004
    ....
  26. ncbi Molecular diagnosis of inheritable neuromuscular disorders. Part I: Genetic determinants of inherited disease and their laboratory detection
    Steven A Greenberg
    Department of Neurology, Division of Neuromuscular Disease, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, Massachusetts 02115, USA
    Muscle Nerve 31:418-30. 2005
    ..The second part discusses the applicability of these tests to the range of neuromuscular disorders...
  27. ncbi Molecular diagnosis of inheritable neuromuscular disorders. Part II: Application of genetic testing in neuromuscular disease
    Steven A Greenberg
    Department of Neurology, Division of Neuromuscular Disease, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, Massachusetts 02115, USA
    Muscle Nerve 31:431-51. 2005
    ..The role of potential multiple genetic influences on the development of acquired neuromuscular diseases is an increasingly active area of research...
  28. ncbi Molecular profiles of inflammatory myopathies
    S A Greenberg
    Department of Neurology, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Neurology 59:1170-82. 2002
    ....
  29. ncbi Inflammatory myopathy associated with mixed connective tissue disease and scleroderma renal crisis
    S A Greenberg
    Department of Neurology, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, Massachusetts 02115, USA
    Muscle Nerve 24:1562-6. 2001
    ..Knowledge of this syndrome, scleroderma renal crisis, and its possible relation to corticosteroid treatment is important to clinicians involved in the management of patients with inflammatory myopathies...
  30. ncbi DNA microarray gene expression analysis technology and its application to neurological disorders
    S A Greenberg
    Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Neurology 57:755-61. 2001
    ....
  31. ncbi Interferon-alpha/beta-mediated innate immune mechanisms in dermatomyositis
    Steven A Greenberg
    Department of Neurology, Division of Neuromuscular Disease, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Ann Neurol 57:664-78. 2005
    ....
  32. ncbi The history of dermatome mapping
    Steven A Greenberg
    Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Arch Neurol 60:126-31. 2003
    ....
  33. ncbi Type I interferon-inducible gene expression in blood is present and reflects disease activity in dermatomyositis and polymyositis
    Ronan J Walsh
    Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Arthritis Rheum 56:3784-92. 2007
    ....
  34. ncbi Permissive environment for B-cell maturation in myositis muscle in the absence of B-cell follicles
    Mohammad Salajegheh
    Department of Neurology, Division of Neuromuscular Disease, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, Massachusetts 02115, USA
    Muscle Nerve 42:576-83. 2010
    ..An atypical lymphoid histology, lacking concentrated collections of germinal-center-like B-cell follicles, is capable of antigen-stimulated clonal maturation of antibody-producing plasma cells...
  35. ncbi Interferon-stimulated gene 15 (ISG15) conjugates proteins in dermatomyositis muscle with perifascicular atrophy
    Mohammad Salajegheh
    Children s Hospital Informatics Program, Division of Neuromuscular Disease, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Ann Neurol 67:53-63. 2010
    ..We investigated interferon-stimulated gene 15 (ISG15), a poorly understood ubiquitin-like modifier, and its enzymatic pathway in dermatomyositis (DM), an autoimmune disease primarily involving muscle and skin...
  36. ncbi Gene expression comparison of biopsies from Duchenne muscular dystrophy (DMD) and normal skeletal muscle
    Judith N Haslett
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 99:15000-5. 2002
    ....
  37. ncbi Molecular classification of nemaline myopathies: "nontyping" specimens exhibit unique patterns of gene expression
    Despina Sanoudou
    Genomics Program and Divisison of Genetics, Children's Hospital Boston, and Harvard Medical School, MA 20115, USA
    Neurobiol Dis 15:590-600. 2004
    ..Determination of the specific molecular differences in NM subgroups may eventually lead to improved prognostic determinations and treatment of these patients...
  38. ncbi Myeloid dendritic cells in inclusion-body myositis and polymyositis
    Steven A Greenberg
    Department of Neurology, Division of Neuromuscular Disease, Brigham and Women s Hospital, 75 Francis Street, and Harvard Medical School, Boston, Massachusetts 02115, USA
    Muscle Nerve 35:17-23. 2007
    ..The stellate morphology of myeloid DCs in dense collections of cells that included T cells suggests local intramuscular antigen presentation in IBM and PM...
  39. ncbi Dermatomyositis-like muscle pathology in patients with chronic graft-versus-host disease
    Jeffrey A Allen
    Department of Neurology, Division of Neuromuscular Disease, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, Massachusetts 02115, USA
    Muscle Nerve 40:643-7. 2009
    ..In each case, perifascicular atrophy, the pathognomonic histologic feature of dermatomyositis (DM), was observed...
  40. ncbi Sarcoplasmic redistribution of nuclear TDP-43 in inclusion body myositis
    Mohammad Salajegheh
    Department of Neurology, Division of Neuromuscular Disease, Brigham and Women s Hospital, and Harvard Medical School, 75 Francis Street, Boston, Massachusetts 02115, USA
    Muscle Nerve 40:19-31. 2009
    ..TDP-43 could be one of many nucleic acid binding proteins that are abnormally present in IBM sarcoplasm. They could potentially interfere with the normal function of extranuclear RNAs that maintain myofiber protein production...
  41. ncbi Immune-mediated necrotizing myopathy associated with statins
    Phyllis Grable-Esposito
    Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Muscle Nerve 41:185-90. 2010
    ....
  42. ncbi Expression profiling reveals altered satellite cell numbers and glycolytic enzyme transcription in nemaline myopathy muscle
    Despina Sanoudou
    Division of Genetics, Children's Hospital, and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 100:4666-71. 2003
    ..This comprehensive study of downstream molecular consequences of NM gene mutations provides insights in the cellular events leading to the NM phenotype...
  43. ncbi Microarray analysis of human nervous system gene expression in neurological disease
    Steven A Greenberg
    Department of Neurology, Division of Neuromuscular Disease, Brigham and Women's Hospital, Children's Hospital Informatics Program, Harvard Medical School, Boston, Massachusetts 02115, USA
    Int Rev Neurobiol 60:135-51. 2004
  44. ncbi Fast-twitch sarcomeric and glycolytic enzyme protein loss in inclusion body myositis
    Kenneth C Parker
    Harvard Partners Center for Genetics and Genomics, Proteomics Core, Harvard Medical School, Boston, Massachusetts USA
    Muscle Nerve 39:739-53. 2009
    ..Although muscle atrophy has long been recognized in IBM, these studies are the first to report specific proteins which are reduced in quantity in IBM muscle...
  45. ncbi Nature of "Tau" immunoreactivity in normal myonuclei and inclusion body myositis
    Mohammad Salajegheh
    Department of Neurology, Division of Neuromuscular Disease, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Muscle Nerve 40:520-8. 2009
    ..Normal myonuclei contain neurofilament H or other unidentified 200 kDa proteins with similar phosphorylated motifs accounting for SMI-31 immunoreactivity...
  46. ncbi CrossChip: a system supporting comparative analysis of different generations of Affymetrix arrays
    Sek Won Kong
    Bauer Center for Genomics Research, Harvard University, Cambridge, MA, USA
    Bioinformatics 21:2116-7. 2005
    ..Our website supports a within-species comparison for human and mouse GeneChip arrays. AVAILABILITY: http://www.crosschip.org..
  47. ncbi Interferon β is associated with type 1 interferon-inducible gene expression in dermatomyositis
    Anne P Liao
    Department of Neurology, Division of Neuromuscular Disease, Brigham and Women s Hospital and Children s Hospital Informatics Program, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Ann Rheum Dis 70:831-6. 2011
    ..To determine whether type 1 interferon (IFN) proteins in blood are associated with downstream type 1 IFN-inducible gene expression in blood from patients with myositis...
  48. ncbi Characterization of human skeletal muscle biopsy samples using shotgun proteomics
    Kenneth C Parker
    Harvard Partners Center for Genetics and Genomics, Cambridge, MA, USA
    J Proteome Res 8:3265-77. 2009
    ..The resulting semiquantitative database should serve as a resource for muscle biochemistry...
  49. ncbi A local antigen-driven humoral response is present in the inflammatory myopathies
    Elizabeth M Bradshaw
    Department of Neurology, Laboratory of Molecular Immunology, Center for Neurologic Diseases and Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 178:547-56. 2007
    ..These findings highlight the need for a revision of the current paradigm of exclusively T cell-mediated intramuscular Ag-specific autoimmunity in inclusion body myositis and polymyositis...
  50. ncbi Discovering statistically significant pathways in expression profiling studies
    Lu Tian
    Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, 680 North Lake Shore Drive, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 102:13544-9. 2005
    ..These predictions have been subsequently corroborated by immunohistochemistry...
  51. ncbi Pushing the genetic frontier with facioscapulohumeral muscular dystrophy
    Steven A Greenberg
    Neurology 68:544-5. 2007
  52. ncbi A neurological and hematological syndrome associated with zinc excess and copper deficiency
    Steven A Greenberg
    J Neurol 251:111-4. 2004

Research Grants5

  1. Gene Expression in Inflammatory Myopathies
    Steven Greenberg; Fiscal Year: 2005
    ..This work may provide further diagnostic approaches to these disorders and contribute to the understanding of their pathogenesis. ..