ANN GRAYBIEL

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. ncbi request reprint The basal ganglia: learning new tricks and loving it
    Ann M Graybiel
    Department of Brain and Cognitive Sciences and the McGovern Institute for Brain Research, Massachusetts Institute of Technology, 43 Vassar Street, 46 6133, Cambridge, MA, 02139 USA
    Curr Opin Neurobiol 15:638-44. 2005
  2. pmc A system for recording neural activity chronically and simultaneously from multiple cortical and subcortical regions in nonhuman primates
    Joseph Feingold
    Massachusetts Institute of Technology, 43 Vassar St, Bldg 46 6133, Cambridge, MA 02139, USA
    J Neurophysiol 107:1979-95. 2012
  3. doi request reprint Habits, rituals, and the evaluative brain
    Ann M Graybiel
    Department of Brain and Cognitive Science and the McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Annu Rev Neurosci 31:359-87. 2008
  4. ncbi request reprint Network-level neuroplasticity in cortico-basal ganglia pathways
    Ann M Graybiel
    Department of Brain and Cognitive Sciences, McGovern Institute for Brain Research, Massachusetts Institute of Technology, 45 Carleton Street, E25 618, Cambridge, MA 02139, USA
    Parkinsonism Relat Disord 10:293-6. 2004
  5. ncbi request reprint Building action repertoires: memory and learning functions of the basal ganglia
    A M Graybiel
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge 02139, USA
    Curr Opin Neurobiol 5:733-41. 1995
  6. ncbi request reprint The basal ganglia and chunking of action repertoires
    A M Graybiel
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Neurobiol Learn Mem 70:119-36. 1998
  7. pmc Local circuit neurons in the striatum regulate neural and behavioral responses to dopaminergic stimulation
    E Saka
    Department of Brain and Cognitive Sciences and the McGovern Institute for Brain Research, Massachusetts Institute of Technology, E25 618, 45 Carleton Street, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 99:9004-9. 2002
  8. pmc Advance cueing produces enhanced action-boundary patterns of spike activity in the sensorimotor striatum
    Terra D Barnes
    McGovern Institute for Brain Research and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, 43 Vassar St, Cambridge, MA 02139, USA
    J Neurophysiol 105:1861-78. 2011
  9. pmc A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia
    H Kawasaki
    Department of Brain and Cognitive Sciences, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 95:13278-83. 1998
  10. pmc Time-varying covariance of neural activities recorded in striatum and frontal cortex as monkeys perform sequential-saccade tasks
    N Fujii
    Department of Brain and Cognitive Sciences and McGovern Institute for Brain Research, Massachusetts Institute of Technology, 45 Carleton Street, E25 618, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 102:9032-7. 2005

Research Grants

  1. EXTRAPYRAMIDAL SYSTEMS
    Ann M Graybiel; Fiscal Year: 2010
  2. ENSEMBLE ACTIVITY IN RAT STRIATUM DURING HABIT LEARNING
    ANN GRAYBIEL; Fiscal Year: 2004
  3. DYNAMIC MACAQUE BASAL GANGLIA SACCADE NETWORKS
    ANN GRAYBIEL; Fiscal Year: 2004
  4. NOVEL SECOND MESSENGER SIGNALING IN THE STRIATUM
    ANN GRAYBIEL; Fiscal Year: 2003
  5. NEUROBIOLOGY OF DRUGS OF ABUSE
    ANN GRAYBIEL; Fiscal Year: 2001
  6. Dynamic Basal Ganglia Saccade Networks
    Ann M Graybiel; Fiscal Year: 2010
  7. ENSEMBLE ACTIVITY IN RAT STRIATUM DURING HABIT LEARNING
    Ann M Graybiel; Fiscal Year: 2010
  8. NOVEL SECOND MESSENGER SIGNALING IN THE STRIATUM
    ANN GRAYBIEL; Fiscal Year: 2007
  9. Dynamic Basal Ganglia Saccade Networks
    ANN GRAYBIEL; Fiscal Year: 2007
  10. ENSEMBLE ACTIVITY IN RAT STRIATUM DURING HABIT LEARNING
    ANN GRAYBIEL; Fiscal Year: 2007

Collaborators

  • J J Canales
  • Dezhe Z Jin
  • Loren Frank
  • Anne C Smith
  • Ming Xu
  • Naotaka Fujii
  • Terra D Barnes
  • Yasuo Kubota
  • William E DeCoteau
  • Richard Courtemanche
  • Esen Saka
  • Joseph Feingold
  • Dan Hu
  • Daniel J Gibson
  • Catherine Thorn
  • Partha Mitra
  • N Fujii
  • Christine Capper-Loup
  • E Saka
  • Pablo M Blazquez
  • Theresa M Desrochers
  • Hideki Shimazu
  • Patrick L Tierney
  • Ken Ichi Amemori
  • Ray Harlan
  • Anna A Dreyer
  • Catherine Stamoulis
  • Jian Bin Mao
  • Emery N Brown
  • H Kawasaki
  • Patricia Harlan
  • Claudia Goodrich
  • Bertha K Madras
  • Neena Kadaba
  • M Iadarola
  • Jun Kojima
  • R Moratalla
  • D J Fitzgerald
  • J P Blumenstiel
  • N Mochizuki
  • D E Housman
  • M Matsuda
  • E J Chen
  • A Ashbacher
  • G M Springett
  • S Toki
  • P Harlan
  • I A Bany
  • S Tonegawa

Detail Information

Publications22

  1. ncbi request reprint The basal ganglia: learning new tricks and loving it
    Ann M Graybiel
    Department of Brain and Cognitive Sciences and the McGovern Institute for Brain Research, Massachusetts Institute of Technology, 43 Vassar Street, 46 6133, Cambridge, MA, 02139 USA
    Curr Opin Neurobiol 15:638-44. 2005
    ..Combined with the new evidence on learning-related functions of the basal ganglia, these studies suggest that the basal ganglia are parts of a brain-wide set of adaptive neural systems promoting optimal motor and cognitive control...
  2. pmc A system for recording neural activity chronically and simultaneously from multiple cortical and subcortical regions in nonhuman primates
    Joseph Feingold
    Massachusetts Institute of Technology, 43 Vassar St, Bldg 46 6133, Cambridge, MA 02139, USA
    J Neurophysiol 107:1979-95. 2012
    ..Used in conjunction with microstimulation and injection methods, this versatile system represents a powerful tool for studying neural network activity in the primate brain...
  3. doi request reprint Habits, rituals, and the evaluative brain
    Ann M Graybiel
    Department of Brain and Cognitive Science and the McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Annu Rev Neurosci 31:359-87. 2008
    ..Culturally based rituals may reflect privileged interactions between the basal ganglia and cortically based circuits that influence social, emotional, and action functions of the brain...
  4. ncbi request reprint Network-level neuroplasticity in cortico-basal ganglia pathways
    Ann M Graybiel
    Department of Brain and Cognitive Sciences, McGovern Institute for Brain Research, Massachusetts Institute of Technology, 45 Carleton Street, E25 618, Cambridge, MA 02139, USA
    Parkinsonism Relat Disord 10:293-6. 2004
    ..This plasticity can become a major source of maladaptive responses in disease states affecting the basal ganglia...
  5. ncbi request reprint Building action repertoires: memory and learning functions of the basal ganglia
    A M Graybiel
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge 02139, USA
    Curr Opin Neurobiol 5:733-41. 1995
    ..Adaptive control of behavior may centrally depend on these circuits and the evaluator-reinforcement circuits that modulate them...
  6. ncbi request reprint The basal ganglia and chunking of action repertoires
    A M Graybiel
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Neurobiol Learn Mem 70:119-36. 1998
    ..The learning and memory functions of the basal ganglia are thus seen as core features of the basal ganglia's influence on motor and cognitive pattern generators...
  7. pmc Local circuit neurons in the striatum regulate neural and behavioral responses to dopaminergic stimulation
    E Saka
    Department of Brain and Cognitive Sciences and the McGovern Institute for Brain Research, Massachusetts Institute of Technology, E25 618, 45 Carleton Street, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 99:9004-9. 2002
    ..We conclude that NK-1-bearing local circuit neurons of the striatum regulate the differential responses of striatal projection neurons to dopamine-mediated signaling...
  8. pmc Advance cueing produces enhanced action-boundary patterns of spike activity in the sensorimotor striatum
    Terra D Barnes
    McGovern Institute for Brain Research and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, 43 Vassar St, Cambridge, MA 02139, USA
    J Neurophysiol 105:1861-78. 2011
    ..Deficits in such representations of learned sequential behaviors could contribute to motor and cognitive problems in a range of neurological disorders affecting the basal ganglia, including Parkinson's disease...
  9. pmc A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia
    H Kawasaki
    Department of Brain and Cognitive Sciences, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 95:13278-83. 1998
    ..The expression of CalDAG-GEFI and CalDAG-GEFII in hematopoietic organs suggests that such control may have broad significance in Ras/Rap regulation of normal and malignant states...
  10. pmc Time-varying covariance of neural activities recorded in striatum and frontal cortex as monkeys perform sequential-saccade tasks
    N Fujii
    Department of Brain and Cognitive Sciences and McGovern Institute for Brain Research, Massachusetts Institute of Technology, 45 Carleton Street, E25 618, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 102:9032-7. 2005
    ..These timing relationships may be signatures of the normal functioning of striatal and frontal cortex during repetitive performance of learned behaviors...
  11. pmc Cellular responses to psychomotor stimulant and neuroleptic drugs are abnormal in mice lacking the D1 dopamine receptor
    R Moratalla
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology 02139, USA
    Proc Natl Acad Sci U S A 93:14928-33. 1996
    ..These findings demonstrate that D2 dopamine receptors can function without the enabling role of D1 receptors but that D1 dopamine receptors are essential for the control of gene expression and motor behavior by psychomotor stimulants...
  12. ncbi request reprint Shifts in striatal responsivity evoked by chronic stimulation of dopamine and glutamate systems
    J J Canales
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, 45 Carleton Street, Cambridge, MA 02139, USA
    Brain 125:2353-63. 2002
    ..The model provides a framework for analysing the neurological alterations associated with disorders of the basal ganglia and their treatment with pharmacotherapies affecting dopamine and glutamate neurotransmitter systems...
  13. ncbi request reprint Activity of striatal neurons reflects dynamic encoding and recoding of procedural memories
    Terra D Barnes
    Department of Brain and Cognitive Sciences and the McGovern Institute for Brain Research, Massachusetts Institute of Technology, 43 Vassar Street, 46 6133, Cambridge, Massachusetts 02139, USA
    Nature 437:1158-61. 2005
    ..We propose that these changes in task representation in cortico-basal ganglia circuits represent neural equivalents of the explore-exploit behaviour characteristic of habit learning...
  14. pmc Learning-related coordination of striatal and hippocampal theta rhythms during acquisition of a procedural maze task
    William E DeCoteau
    Department of Psychology, St Lawrence University, Canton, NY 13617, USA
    Proc Natl Acad Sci U S A 104:5644-9. 2007
    ..Experience-dependent changes in coordination of oscillatory activity across brain structures thus may parallel the well known plasticity of spike activity that occurs as a function of experience...
  15. ncbi request reprint Oscillations of local field potentials in the rat dorsal striatum during spontaneous and instructed behaviors
    William E DeCoteau
    Department of Psychology, St Lawrence University, Canton, New York, USA
    J Neurophysiol 97:3800-5. 2007
    ..We suggest that modulation of oscillatory activity in the striatum may be a key feature of neural processing related to the control of voluntary behavior...
  16. ncbi request reprint Repetitive behaviors in monkeys are linked to specific striatal activation patterns
    Esen Saka
    Department of Neurology, Akdeniz University Hospital, 07059 Antalya, Turkey
    J Neurosci 24:7557-65. 2004
    ....
  17. ncbi request reprint A network representation of response probability in the striatum
    Pablo M Blazquez
    Washington University School of Medicine, 4566 Scott Avenue, St Louis, MO 63110, USA
    Neuron 33:973-82. 2002
    ..Such a network signal, proportional to current response probability, could be crucial to the learning and decision functions of the basal ganglia...
  18. ncbi request reprint Dynamic analysis of learning in behavioral experiments
    Anne C Smith
    Neuroscience Statistics Research Laboratory, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, Massachusetts 02114 2696, USA
    J Neurosci 24:447-61. 2004
    ....
  19. ncbi request reprint Synchronous, focally modulated beta-band oscillations characterize local field potential activity in the striatum of awake behaving monkeys
    Richard Courtemanche
    Department of Exercise Science, Concordia University, Montreal, Canada H4B 1R6
    J Neurosci 23:11741-52. 2003
    ..We suggest that the background beta-band oscillations in the striatum could help to focus action-selection network functions of cortico-basal ganglia circuits...
  20. ncbi request reprint Representation of action sequence boundaries by macaque prefrontal cortical neurons
    Naotaka Fujii
    Department of Brain and Cognitive Sciences and McGovern Institute for Brain Research, Massachusetts Institute of Technology, 45 Carleton Street, E25 618, Cambridge, MA 02139, USA
    Science 301:1246-9. 2003
    ..Sequence bounding may thus reflect a general mechanism for encoding biological information...
  21. ncbi request reprint Concurrent activation of dopamine D1 and D2 receptors is required to evoke neural and behavioral phenotypes of cocaine sensitization
    Christine Capper-Loup
    Department of Neurology, University Hospital, 3010 Bern, Switzerland
    J Neurosci 22:6218-27. 2002
    ....
  22. ncbi request reprint Pathophysiology of Tourette's syndrome: striatal pathways revisited
    Esen Saka
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, 45 Carleton Street, E25 618, Cambridge, MA 02139, USA
    Brain Dev 25:S15-9. 2003
    ....

Research Grants61

  1. EXTRAPYRAMIDAL SYSTEMS
    Ann M Graybiel; Fiscal Year: 2010
    ..anatomically defined loops and the interactions among them in mediating behaviors, our study will contribute greatly to the understanding of neural bases of these disorders and to the development of treatment and cure of such diseases ..
  2. ENSEMBLE ACTIVITY IN RAT STRIATUM DURING HABIT LEARNING
    ANN GRAYBIEL; Fiscal Year: 2004
    ....
  3. DYNAMIC MACAQUE BASAL GANGLIA SACCADE NETWORKS
    ANN GRAYBIEL; Fiscal Year: 2004
    ..The results obtained will have significance for understanding forebrain oculomotor control circuits and for understanding oculomotor defects in extrapyramidal disorders. ..
  4. NOVEL SECOND MESSENGER SIGNALING IN THE STRIATUM
    ANN GRAYBIEL; Fiscal Year: 2003
    ..Understanding these novel second messenger signaling molecules will therefore bring insights to understanding fundamentally important brain functions and will help in elucidating brain disorders. ..
  5. NEUROBIOLOGY OF DRUGS OF ABUSE
    ANN GRAYBIEL; Fiscal Year: 2001
    ..In addition, these experiments will provide new and much-needed data on molecular responses to these drugs in acutely treated non human primates, a critical bridge toward understanding their effects in humans. ..
  6. Dynamic Basal Ganglia Saccade Networks
    Ann M Graybiel; Fiscal Year: 2010
    ..Repetitive movement disorders are a hallmark of basal ganglia dysfunction. Our goal is to illuminate mechanisms disordered in these disabling human conditions. ..
  7. ENSEMBLE ACTIVITY IN RAT STRIATUM DURING HABIT LEARNING
    Ann M Graybiel; Fiscal Year: 2010
    ..We thus believe that the proposed work is important for the mission of the NIMH, which is to understand, prevent and cure mental illness. ..
  8. NOVEL SECOND MESSENGER SIGNALING IN THE STRIATUM
    ANN GRAYBIEL; Fiscal Year: 2007
    ..The work proposed is highly significant for understanding signaling in key basal ganglia neurons whose function is essential for normal behavior and whose dysfunction leads to major extrapyramidal disorders. ..
  9. Dynamic Basal Ganglia Saccade Networks
    ANN GRAYBIEL; Fiscal Year: 2007
    ..Repetitive movement disorders are a hallmark of basal ganglia dysfunction. Our goal is to illuminate mechanisms disordered in these disabling human conditions. ..
  10. ENSEMBLE ACTIVITY IN RAT STRIATUM DURING HABIT LEARNING
    ANN GRAYBIEL; Fiscal Year: 2007
    ..We thus believe that the proposed work is important for the mission of the NIMH, which is to understand, prevent and cure mental illness. ..
  11. EXTRAPYRAMIDAL SYSTEMS
    ANN GRAYBIEL; Fiscal Year: 2006
    ..abstract_text> ..
  12. EXTRAPYRAMIDAL SYSTEMS
    ANN GRAYBIEL; Fiscal Year: 2001
    ..First, it may help uncover the neural substrates of focal and somatotypically distributed banal ganglia movement disorders. Second, it should help identifying what transformations occur in cortical-basal ganglia loops. ..
  13. EXTRAPYRAMIDAL SYSTEM
    ANN GRAYBIEL; Fiscal Year: 1993
    ..By coordinating observations in monkey and human, it is hoped that significant progress can be made toward an understanding of the basal ganglia in health and disease...
  14. DEVELOPMENT OF THE STRIATUM
    ANN GRAYBIEL; Fiscal Year: 1993
    ....
  15. NEUROBIOLOGY OF DRUGS OF ABUSE
    ANN GRAYBIEL; Fiscal Year: 1993
    ..The patterns of regulation identified should lead to a better understanding of possible mechanisms underlying the powerful effects of these drugs on central nervous system function including long-term neural changes...