R Gilberto Gonzalez

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi Rapid identification of a major diffusion/perfusion mismatch in distal internal carotid artery or middle cerebral artery ischemic stroke
    Reza Hakimelahi
    Neuroradiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    BMC Neurol 12:132. 2012
  2. ncbi Clinical MRI of acute ischemic stroke
    R Gilberto Gonzalez
    Neuroradiology Division, Massachusetts General Hospital, Boston, MA, USA
    J Magn Reson Imaging 36:259-71. 2012
  3. ncbi Improved outcome prediction using CT angiography in addition to standard ischemic stroke assessment: results from the STOPStroke study
    R Gilberto Gonzalez
    Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 7:e30352. 2012
  4. ncbi Stability of large diffusion/perfusion mismatch in anterior circulation strokes for 4 or more hours
    R Gilberto Gonzalez
    Neuroradiology Division, Department of Radiology, Massachusetts General Hospital, Boston, Harvard Medical School, Boston, MA 02114, USA
    BMC Neurol 10:13. 2010
  5. ncbi New insights into the neuroimmunity of SIV infection by magnetic resonance spectroscopy
    R Gilberto Gonzalez
    Harvard Medical School, Boston, MA 02115, USA
    J Neuroimmune Pharmacol 1:152-9. 2006
  6. ncbi In vivo proton magnetic resonance spectroscopy reveals region specific metabolic responses to SIV infection in the macaque brain
    Eva Maria Ratai
    Neuroradiology Division, Department of Radiology and A A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    BMC Neurosci 10:63. 2009
  7. ncbi Brain creatine elevation and N-Acetylaspartate reduction indicates neuronal dysfunction in the setting of enhanced glial energy metabolism in a macaque model of neuroAIDS
    Eva Maria Ratai
    Neuroradiology Division, Department of Radiology and Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts, USA
    Magn Reson Med 66:625-34. 2011
  8. ncbi Brain metabolites B1-corrected proton T1 mapping in the rhesus macaque at 3 T
    Songtao Liu
    Department of Radiology, New York University School of Medicine, New York, New York, USA
    Magn Reson Med 63:865-71. 2010
  9. ncbi Metabolic markers of neuronal injury correlate with SIV CNS disease severity and inoculum in the macaque model of neuroAIDS
    Margaret R Lentz
    Massachusetts General Hospital, Department of Neuroradiology, Boston, Massachusetts 02114 2696, USA
    Magn Reson Med 59:475-84. 2008
  10. ncbi Proton magnetic resonance spectroscopy reveals neuroprotection by oral minocycline in a nonhuman primate model of accelerated NeuroAIDS
    Eva Maria Ratai
    AA Martinos Center for Biomedical Imaging and Neuroradiology Division, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America
    PLoS ONE 5:e10523. 2010

Research Grants

  1. ADVANCED MR SPECTROSCOPY OF SIV BRAIN INJURY
    Ramon Gonzalez; Fiscal Year: 2001
  2. PREDICTING BRAIN TUMOR CHEMOSENSITIVITY BY IN VIVO MRS
    Ramon Gonzalez; Fiscal Year: 2002
  3. MOLECULAR NEUROIMAGING OF AIDS DEMENTIA--ANIMAL MODELS
    Ramon Gonzalez; Fiscal Year: 2002
  4. MR Spectroscopy of SIV Brain Injury
    Ramon Gonzalez; Fiscal Year: 2009

Detail Information

Publications91

  1. ncbi Rapid identification of a major diffusion/perfusion mismatch in distal internal carotid artery or middle cerebral artery ischemic stroke
    Reza Hakimelahi
    Neuroradiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    BMC Neurol 12:132. 2012
    ....
  2. ncbi Clinical MRI of acute ischemic stroke
    R Gilberto Gonzalez
    Neuroradiology Division, Massachusetts General Hospital, Boston, MA, USA
    J Magn Reson Imaging 36:259-71. 2012
    ..This will change only when clinical trials prove that stroke physiology as revealed by MRI is superior to time from stroke onset in promoting good clinical outcomes...
  3. ncbi Improved outcome prediction using CT angiography in addition to standard ischemic stroke assessment: results from the STOPStroke study
    R Gilberto Gonzalez
    Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 7:e30352. 2012
    ..To improve ischemic stroke outcome prediction using imaging information from a prospective cohort who received admission CT angiography (CTA)...
  4. ncbi Stability of large diffusion/perfusion mismatch in anterior circulation strokes for 4 or more hours
    R Gilberto Gonzalez
    Neuroradiology Division, Department of Radiology, Massachusetts General Hospital, Boston, Harvard Medical School, Boston, MA 02114, USA
    BMC Neurol 10:13. 2010
    ..The purpose of this study was to determine the persistence of a diffusion/perfusion mismatch in patients with ICA or proximal MCA occlusions...
  5. ncbi New insights into the neuroimmunity of SIV infection by magnetic resonance spectroscopy
    R Gilberto Gonzalez
    Harvard Medical School, Boston, MA 02115, USA
    J Neuroimmune Pharmacol 1:152-9. 2006
    ..These observations explain the clinical success of antiretroviral therapy in reducing the incidence of HIV-associated dementia and minor cognitive/motor disorder and suggest novel targets for drug development...
  6. ncbi In vivo proton magnetic resonance spectroscopy reveals region specific metabolic responses to SIV infection in the macaque brain
    Eva Maria Ratai
    Neuroradiology Division, Department of Radiology and A A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    BMC Neurosci 10:63. 2009
    ..Metabolic changes in the frontal cortex, basal ganglia and white matter in 18 SIV-infected macaques were investigated using MRS during the first month of infection...
  7. ncbi Brain creatine elevation and N-Acetylaspartate reduction indicates neuronal dysfunction in the setting of enhanced glial energy metabolism in a macaque model of neuroAIDS
    Eva Maria Ratai
    Neuroradiology Division, Department of Radiology and Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts, USA
    Magn Reson Med 66:625-34. 2011
    ..Given these data, elevated creatine may reflect enhanced high-energy phosphate turnover in highly metabolizing activated astrocytes and microglia...
  8. ncbi Brain metabolites B1-corrected proton T1 mapping in the rhesus macaque at 3 T
    Songtao Liu
    Department of Radiology, New York University School of Medicine, New York, New York, USA
    Magn Reson Med 63:865-71. 2010
    ....
  9. ncbi Metabolic markers of neuronal injury correlate with SIV CNS disease severity and inoculum in the macaque model of neuroAIDS
    Margaret R Lentz
    Massachusetts General Hospital, Department of Neuroradiology, Boston, Massachusetts 02114 2696, USA
    Magn Reson Med 59:475-84. 2008
    ..In considering therapy for neuroAIDS the findings here support prevention of the encephalitic process, but suggest that suppressing the formation of multinucleated giant cells alone would be insufficient to prevent neuronal injury...
  10. ncbi Proton magnetic resonance spectroscopy reveals neuroprotection by oral minocycline in a nonhuman primate model of accelerated NeuroAIDS
    Eva Maria Ratai
    AA Martinos Center for Biomedical Imaging and Neuroradiology Division, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America
    PLoS ONE 5:e10523. 2010
    ....
  11. ncbi Glial tumor grading and outcome prediction using dynamic spin-echo MR susceptibility mapping compared with conventional contrast-enhanced MR: confounding effect of elevated rCBV of oligodendrogliomas [corrected]
    Michael H Lev
    Departments of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    AJNR Am J Neuroradiol 25:214-21. 2004
    ..A significant proportion of low-grade glial neoplasms, most notably oligodendrogliomas, may display high rCBV foci not reflective of high-grade histopathology...
  12. ncbi Infarct volume is a pivotal biomarker after intra-arterial stroke therapy
    Albert J Yoo
    Departments of Radiology, Massachusetts General Hospital, Boston, MA, USA
    Stroke 43:1323-30. 2012
    ....
  13. ncbi Hyperdense basilar artery sign on unenhanced CT predicts thrombus and outcome in acute posterior circulation stroke
    Gregory V Goldmakher
    Massachusetts General Hospital, Department of Neurology, MGH Stroke Research Center, 175 Cambridge Street, suite 300 Boston, MA 02114, USA
    Stroke 40:134-9. 2009
    ..Our purpose was to determine whether the hyperdense basilar artery (HDBA) sign has utility in detecting thrombosis and predicting outcome in patients presenting with signs and symptoms of posterior circulation stroke...
  14. ncbi Minocycline inhibition of monocyte activation correlates with neuronal protection in SIV neuroAIDS
    Jennifer H Campbell
    Department of Biology, Boston College, Chestnut Hill, Massachusetts, United States of America
    PLoS ONE 6:e18688. 2011
    ..Minocycline is a tetracycline antibiotic that has been proposed as a potential conjunctive therapy for HIV-1 associated cognitive disorders. Precise mechanism(s) of minocycline's functions are not well defined...
  15. ncbi Predictors of functional outcome vary by the hemisphere of involvement in major ischemic stroke treated with intra-arterial therapy: a retrospective cohort study
    Albert J Yoo
    Neuroradiology Division, Department of Radiology, Massachusetts General Hospital, Boston, Harvard Medical School, Boston, MA 02114, USA
    BMC Neurol 10:25. 2010
    ..The purpose of this study was to characterize the impact of stroke lateralization on both functional outcome and its predictors in a well-defined population of anterior circulation proximal artery occlusions treated with IAT...
  16. ncbi Severity of leukoaraiosis and susceptibility to infarct growth in acute stroke
    Hakan Ay
    A A Martinos Center for Biomedical Imaging and Stroke Service, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Room 2301, Charlestown, MA 02129, USA
    Stroke 39:1409-13. 2008
    ..We hypothesized that the volume of LA correlated with the proportion of initially ischemic but eventually infarcted tissue in acute human stroke...
  17. ncbi Predicting cerebral ischemic infarct volume with diffusion and perfusion MR imaging
    Pamela W Schaefer
    Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    AJNR Am J Neuroradiol 23:1785-94. 2002
    ..Diffusion and perfusion MR imaging have proved useful in the assessment of acute stroke. We evaluated the utility of these techniques in detecting acute ischemic infarction and in predicting final infarct size...
  18. ncbi Elderly patients are at higher risk for poor outcomes after intra-arterial therapy
    Ronil V Chandra
    Department of Radiology, Divisions of Interventional, Massachusetts General Hospital, Boston, MA, USA
    Stroke 43:2356-61. 2012
    ..We compare safety and clinical outcomes of multimodal IAT in elderly versus nonelderly patients and investigate differences in baseline health and disability as possible explanatory factors...
  19. ncbi Admission CT perfusion is an independent predictor of hemorrhagic transformation in acute stroke with similar accuracy to DWI
    Leticia C S Souza
    Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Mass, USA
    Cerebrovasc Dis 33:8-15. 2012
    ..The utility of admission CT perfusion (CTP) to that of diffusion-weighted imaging (DWI) as a predictor of hemorrhagic transformation (HT) in acute stroke was compared...
  20. ncbi Regional metabolite T2 in the healthy rhesus macaque brain at 7T
    Songtao Liu
    Department of Radiology, New York University School of Medicine, New York, New York, USA
    Magn Reson Med 59:1165-9. 2008
    ..The T(2) histograms from 320 voxels in each animal for NAA, Cr, and Cho were similar in position and shape, indicating that they are potentially characteristic of "healthy" in this species...
  21. ncbi A prospective longitudinal in vivo 1H MR spectroscopy study of the SIV/macaque model of neuroAIDS
    Robert A Fuller
    Massachusetts General Hospital NMR Center and Neuroradiology Division, Harvard Medical School, Charlestown, MA, USA
    BMC Neurosci 5:10. 2004
    ..Our goal was to undertsand the dynamics of cerebral injury by performing a longitudinal in vivo 1H MRS study of the SIV/macaque model of neuroAIDS...
  22. ncbi Combining acute diffusion-weighted imaging and mean transmit time lesion volumes with National Institutes of Health Stroke Scale Score improves the prediction of acute stroke outcome
    Albert J Yoo
    Department of Radiology, Massachusetts General Hospital, Boston, Mass 02114, USA
    Stroke 41:1728-35. 2010
    ....
  23. ncbi Spot sign score predicts rapid bleeding in spontaneous intracerebral hemorrhage
    Javier M Romero
    Division of Neuroradiology, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Gray B, Office 279, Boston, MA 01778, USA
    Emerg Radiol 19:195-202. 2012
    ..Spot sign score on presentation correlates with rate of expansion, supporting the hypothesis that high spot sign scores likely reflect active bleeding in acute ICH...
  24. ncbi Metabolite proton T(2) mapping in the healthy rhesus macaque brain at 3 T
    Songtao Liu
    Department of Radiology, New York University School of Medicine, New York, New York 10016, USA
    Magn Reson Med 62:1292-9. 2009
    ....
  25. ncbi Arterial input function placement for accurate CT perfusion map construction in acute stroke
    Rafael M Ferreira
    Department of Radiology, Massachusetts General Hospital, Boston, MA, USA
    AJR Am J Roentgenol 194:1330-6. 2010
    ..The objective of our study was to evaluate the effect of varying arterial input function (AIF) placement on the qualitative and quantitative CT perfusion parameters...
  26. ncbi Diffusion-weighted MR imaging in closed head injury: high correlation with initial glasgow coma scale score and score on modified Rankin scale at discharge
    Pamela W Schaefer
    Department of Radiology, Massachusetts General Hospital, 55 Fruit St, Gray B285, Boston, MA 02114, USA
    Radiology 233:58-66. 2004
    ..To determine whether diffusion-weighted magnetic resonance (MR) imaging findings and conventional MR imaging findings correlate with initial Glasgow Coma Scale score and score on modified Rankin scale at discharge...
  27. ncbi Diffusion weighted imaging reversibility in the brainstem following successful recanalization of acute basilar artery occlusion
    Albert J Yoo
    Department of Neuroradiology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Neurointerv Surg 2:195-7. 2010
    ..The degree of apparent diffusion coefficient reduction on pretreatment MRI may not adequately identify which DWI abnormal brainstem tissue is potentially reversible...
  28. ncbi CT cerebral blood flow maps optimally correlate with admission diffusion-weighted imaging in acute stroke but thresholds vary by postprocessing platform
    Shahmir Kamalian
    Department of Radiology, Massachusetts General Hospital, Gray B285, 55 Fruit Street, Boston, MA 02114, USA
    Stroke 42:1923-8. 2011
    ..Our purposes were to: (1) determine the optimal CT perfusion parameter to define infarct core using various postprocessing platforms; and (2) establish the degree of variability in threshold values between these different platforms...
  29. ncbi A pilot study of normobaric oxygen therapy in acute ischemic stroke
    Aneesh B Singhal
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Mass 02114, USA
    Stroke 36:797-802. 2005
    ..Therapies that transiently prevent ischemic neuronal death can potentially extend therapeutic time windows for stroke thrombolysis. We conducted a pilot study to investigate the effects of high-flow oxygen in acute ischemic stroke...
  30. ncbi Cross-sectional and longitudinal reproducibility of rhesus macaque brain metabolites: a proton MR spectroscopy study at 3 T
    William E Wu
    Department of Radiology, New York University School of Medicine, New York, New York 10016, USA
    Magn Reson Med 65:1522-31. 2011
    ....
  31. ncbi Factor analysis reveals differences in brain metabolism in macaques with SIV/AIDS and those with SIV-induced encephalitis
    Margaret R Lentz
    Department of Neuroradiology A A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA
    NMR Biomed 21:878-87. 2008
    ..These results suggest that the divergent pathways of N-acetylaspartate and creatine in this disease may enable the commonly reported ratio N-acetylaspartate/creatine to be a more sensitive marker of disease severity...
  32. ncbi Regional ischemic vulnerability of the brain to hypoperfusion: the need for location specific computed tomography perfusion thresholds in acute stroke patients
    Seyedmehdi Payabvash
    Massachusetts General Hospital and Harvard Medical School, Department of Radiology, Gray 241H, Boston, MA 02114 9657, USA
    Stroke 42:1255-60. 2011
    ..To characterize the spatial pattern of cerebral ischemic vulnerability to hypoperfusion in stroke patients...
  33. ncbi Impact of short-term combined antiretroviral therapy on brain virus burden in simian immunodeficiency virus-infected and CD8+ lymphocyte-depleted rhesus macaques
    Lakshmanan Annamalai
    Division of Comparative Pathology, New England Primate Research Center, Harvard Medical School, Southborough, MA 01772, USA
    Am J Pathol 177:777-91. 2010
    ....
  34. ncbi Automatic repositioning of MRSI voxels in longitudinal studies: impact on reproducibility of metabolite concentration measurements
    Eva Maria Ratai
    Massachusetts General Hospital, A A Martinos Center for Biomedical Imaging, Department of Radiology and Neuroradiology Division, Charlestown, Massachusetts 02129, USA
    J Magn Reson Imaging 27:1188-93. 2008
    ..However, one source of variability in such exams arises from imperfect relocalization of the MRSI grid in the follow-up exams...
  35. ncbi Radiation necrosis versus glioma recurrence: conventional MR imaging clues to diagnosis
    Mark E Mullins
    Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA
    AJNR Am J Neuroradiol 26:1967-72. 2005
    ..Together with clinical and functional imaging findings, these results may assist in determining the need for biopsy...
  36. ncbi Serial diffusion tensor MRI after transient and permanent cerebral ischemia in nonhuman primates
    Yutong Liu
    Martinos Center, Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129 2060, USA
    Stroke 38:138-45. 2007
    ....
  37. ncbi Assessing tissue viability with MR diffusion and perfusion imaging
    Pamela W Schaefer
    Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    AJNR Am J Neuroradiol 24:436-43. 2003
    ..ADC, DW intensity, FA, and rCBV ratios may provide adjunctive information...
  38. ncbi Whole-brain CT perfusion measurement of perfused cerebral blood volume in acute ischemic stroke: probability curve for regional infarction
    George J Hunter
    MGH Perfusion and Physiology Analysis Laboratory, Massachusetts General Hospital, Gray Bldg, Rm 285, 55 Fruit St, Boston, MA 02114, USA
    Radiology 227:725-30. 2003
    ..To determine the probability curve for regional cerebral infarction as a function of percentage normalized perfused cerebral blood volume (pCBV) in patients with acute ischemic stroke...
  39. ncbi Acute ischemic stroke: infarct core estimation on CT angiography source images depends on CT angiography protocol
    Benjamin Pulli
    Division of Neuroradiology and Interventional Neuroradiology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St, Gray 241, Boston, MA 02114, USA
    Radiology 262:593-604. 2012
    ....
  40. ncbi Prevalence of traumatic dural venous sinus thrombosis in high-risk acute blunt head trauma patients evaluated with multidetector CT venography
    Josser E Delgado Almandoz
    Division of Neuroradiology, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Radiology 255:570-7. 2010
    ..To determine the prevalence of trauma-related dural venous sinus thrombosis (DVST) in high-risk patients with blunt head trauma who are examined with multidetector computed tomographic (CT) venography...
  41. ncbi Multidetector CT angiography in the evaluation of acute blunt head and neck trauma: a proposed acute craniocervical trauma scoring system
    Josser E Delgado Almandoz
    Division of Neuroradiology, Department of Radiology, Massachusetts General Hospital, Gray 2 Room 273A, 55 Fruit St, Boston, MA 02114, USA
    Radiology 254:236-44. 2010
    ....
  42. ncbi Existence of the diffusion-perfusion mismatch within 24 hours after onset of acute stroke: dependence on proximal arterial occlusion
    William A Copen
    Department of Radiology, Massachusetts General Hospital, GRB 273A, 55 Fruit St, Boston, MA 02114, USA
    Radiology 250:878-86. 2009
    ....
  43. ncbi MRI-based selection for intra-arterial stroke therapy: value of pretreatment diffusion-weighted imaging lesion volume in selecting patients with acute stroke who will benefit from early recanalization
    Albert J Yoo
    Department of Neuroradiology and Interventional Neuroradiology, Massachusetts General Hospital, 55 Fruit Street, Gray 241, Boston, MA 02114, USA
    Stroke 40:2046-54. 2009
    ..In patients with initial infarcts <70 cm(3), we sought to determine what effect recanalization and time to recanalization had on infarct growth and functional outcome...
  44. ncbi Arterial wall enhancement overlying carotid plaque on CT angiography correlates with symptoms in patients with high grade stenosis
    Javier M Romero
    Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Stroke 40:1894-6. 2009
    ..Our purpose was to correlate acute neurological symptoms with either carotid artery wall enhancement or plaque calcification, on axial CT angiographic source images (CTA-SI) of patients with severe (>or=70%) ICA stenosis...
  45. ncbi Magnetic resonance spectroscopy reveals that activated monocytes contribute to neuronal injury in SIV neuroAIDS
    Kenneth Williams
    Viral Pathogenesis, RE113 Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 115:2534-45. 2005
    ..These results underscore the role of activated monocytes and monocyte infection outside of the brain in driving CNS disease...
  46. ncbi Systematic characterization of the computed tomography angiography spot sign in primary intracerebral hemorrhage identifies patients at highest risk for hematoma expansion: the spot sign score
    Josser E Delgado Almandoz
    Division of Neuroradiology, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Stroke 40:2994-3000. 2009
    ..We aim to systematically characterize the spot sign to identify features that are most predictive of hematoma expansion and construct a spot sign scoring system...
  47. ncbi Growth-associated protein-43 and ephrin B3 induction in the brain of adult SIV-infected rhesus macaques
    Susan V Westmoreland
    Division of Comparative Pathology, New England Primate Research Center, Harvard Medical School, Southborough, MA 01772, USA
    J Neurovirol 17:455-68. 2011
    ....
  48. ncbi CT and conventional and diffusion-weighted MR imaging in acute stroke: study in 691 patients at presentation to the emergency department
    Mark E Mullins
    Neuroradiology Division, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St, GRB285, Boston, MA 02114, USA
    Radiology 224:353-60. 2002
    ..After 12 hours, accuracy was equivalent. CONCLUSION: In the diagnosis of stroke in the early period (<12 hours after presentation), DW MR imaging is superior to conventional MR imaging and CT...
  49. ncbi Avoiding "pseudo-reversibility" of CT-CBV infarct core lesions in acute stroke patients after thrombolytic therapy: the need for algorithmically "delay-corrected" CT perfusion map postprocessing software
    Pamela W Schaefer
    Department of Radiology, Division of Neuroradiology, Gray 273A, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Stroke 40:2875-8. 2009
    ..We sought to determine: (1) the prevalence of CT-CBV "reversibility" in AIS patients treated with thrombolytic therapy, and (2) whether the presumed tissue salvage of these CT-CBV lesions depends on the CTP software...
  50. ncbi Proton MR spectroscopic imaging of rhesus macaque brain in vivo at 7T
    Oded Gonen
    Department of Radiology, New York University School of Medicine, New York, New York 10016, USA
    Magn Reson Med 59:692-9. 2008
    ..Their metabolites' linewidths, 9+/-2 Hz, yield excellent spectral resolution as well. These results indicate that 3D (1)H-MRSI can be integrated into comprehensive MR studies in primates at such high fields...
  51. ncbi Myocarditis in CD8-depleted SIV-infected rhesus macaques after short-term dual therapy with nucleoside and nucleotide reverse transcriptase inhibitors
    Lakshmanan Annamalai
    Division of Comparative Pathology, New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts, United States of America
    PLoS ONE 5:e14429. 2010
    ....
  52. ncbi Magnetic resonance imaging improves detection of intracerebral hemorrhage over computed tomography after intra-arterial thrombolysis
    David M Greer
    Department of Neurology, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA
    Stroke 35:491-5. 2004
    ....
  53. ncbi Characterization and evolution of diffusion MR imaging abnormalities in stroke patients undergoing intra-arterial thrombolysis
    Pamela W Schaefer
    Department of Radiology, Division of Neuroradiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    AJNR Am J Neuroradiol 25:951-7. 2004
    ..ADC values, ADC ratios, and DWI ratios may be useful in identifying the portion of abnormal tissue that is potentially salvageable after reperfusion therapy...
  54. ncbi 'Footprints' of transient ischemic attacks: a diffusion-weighted MRI study
    Hakan Ay
    Stroke Service of the Neurology, Massachusetts General Hospital, and Harvard Medical School, Boston, Mass, USA
    Cerebrovasc Dis 14:177-86. 2002
    ..We aimed to determine the proportion and clinical characteristics of patients with TIA who harbor infarction(s) on DWI...
  55. ncbi CT angiography source images acquired with a fast-acquisition protocol overestimate infarct core on diffusion weighted images in acute ischemic stroke
    Albert J Yoo
    Division of Neuroradiology, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    J Neuroimaging 22:329-35. 2012
    ..We sought to test this relationship using our current CTA protocol optimized for faster scan acquisition...
  56. ncbi Dynamic susceptibility contrast perfusion imaging of cerebral ischemia in nonhuman primates: comparison of Gd-DTPA and NMS60
    Yutong Liu
    Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Magn Reson Imaging 22:461-6. 2005
    ..Along with its previously demonstrated advantage for T1-enhanced imaging, the current results show that NMS60 is a viable contrast agent for use in stroke patients...
  57. ncbi Proton high-resolution magic angle spinning NMR analysis of fresh and previously frozen tissue of human prostate
    Chin-Lee Wu
    Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Magn Reson Med 50:1307-11. 2003
    ..Furthermore, although storage conditions affect absolute metabolite concentrations in NMR analysis, relative metabolite concentrations are less affected...
  58. ncbi Comparison of image quality between conventional and low-dose nonenhanced head CT
    Mark E Mullins
    Neuroradiology Division, Massachusetts General Hospital and the Harvard Medical School, Boston, MA, USA
    AJNR Am J Neuroradiol 25:533-8. 2004
    ..CONCLUSION: Although 90-mAs head CT images were moderately noisier than 170-mAs images, they were rated as having acceptable diagnostic quality...
  59. ncbi Imaging-based treatment selection for intravenous and intra-arterial stroke therapies: a comprehensive review
    Albert J Yoo
    Massachusetts General Hospital, 55 Fruit Street, Gray 241, Boston, MA 02114, USA
    Expert Rev Cardiovasc Ther 9:857-76. 2011
    ..This article will review the major studies that have investigated the role of imaging in patient selection for both intravenous and intra-arterial therapies...
  60. ncbi Parenchymal abnormalities associated with cerebral venous sinus thrombosis: assessment with diffusion-weighted MR imaging
    Mark E Mullins
    Department of Radiology, 55 Fruit St, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    AJNR Am J Neuroradiol 25:1666-75. 2004
    ..This information may be important in prospectively determining severity of irreversible injury and in patient treatment...
  61. ncbi Case records of the Massachusetts General Hospital. Case 21-2007. A 58-year-old woman with headaches, weakness, and strokelike episodes
    David M Greer
    Department of Neurology, Harvard Medical School, USA
    N Engl J Med 357:164-73. 2007
  62. ncbi MRI changes in the rat hippocampus following proton radiosurgery
    James D Rabinov
    Division of Neuroradiology, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Stereotact Funct Neurosurg 82:156-64. 2004
    ..To define radiographic dose-response relationships for proton radiosurgery using a rat brain model...
  63. ncbi Intracranial hemorrhage complicating acute stroke: how common is hemorrhagic stroke on initial head CT scan and how often is initial clinical diagnosis of acute stroke eventually confirmed?
    Mark E Mullins
    Department of Radiology, Division of Neuroradiology, Massachusetts General Hospital, Boston, MA 02114, USA
    AJNR Am J Neuroradiol 26:2207-12. 2005
    ..In addition, we sought to determine the frequency with which initial clinical diagnosis acute stroke is confirmed in this group...
  64. ncbi Magnetic resonance perfusion-weighted imaging of acute cerebral infarction: effect of the calculation methods and underlying vasculopathy
    Kei Yamada
    Massachusetts General Hospital NMR Center, Harvard Medical School, Boston, USA
    Stroke 33:87-94. 2002
    ..Steno-occlusive disease in the parent vessels is another factor that may affect the results of the PWI. The purpose of this study was to elucidate the effect of the calculation methods and underlying vasculopathy on PWI...
  65. ncbi The effect of varying user-selected input parameters on quantitative values in CT perfusion maps
    Pina C Sanelli
    Department of Radiology, Weill Medical College of Cornell University, New York Presbyterian Hospital, 520 East 68th Street, Starr Pavilion, Starr 630, New York, NY 10021, USA
    Acad Radiol 11:1085-92. 2004
    ..The purpose of this study was to investigate the degree to which both major and minor variations of these user-defined inputs would affect the final quantitative values of CBF, CBV, and MTT...
  66. ncbi CT angiography predicts use of tertiary interventional services in acute ischemic stroke patients
    Lisa E Thomas
    Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA, USA
    Int J Emerg Med 4:62. 2011
    ..abstract:..
  67. ncbi Astrocytic induction of matrix metalloproteinase-9 and edema in brain hemorrhage
    Emiri Tejima
    Neuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital, and Program in Neuroscience, Harvard Medical School, Boston, MA, USA
    J Cereb Blood Flow Metab 27:460-8. 2007
    ....
  68. ncbi Case records of the Massachusetts General Hospital. Case 8-2006. A 71-year-old woman with Crohn's disease and altered mental status
    Daniel K Podolsky
    Gastrointestinal Unit, Massachusetts General Hospital, USA
    N Engl J Med 354:1178-84. 2006
  69. ncbi Total occlusion versus hairline residual lumen of the internal carotid arteries: accuracy of single section helical CT angiography
    Michael H Lev
    Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    AJNR Am J Neuroradiol 24:1123-9. 2003
    ..In equivocal cases, conventional catheter arteriography may be desirable to confirm the diagnosis...
  70. ncbi A multi-center 1H MRS study of the AIDS dementia complex: validation and preliminary analysis
    Patricia Lani Lee
    NMR Center, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02111, USA
    J Magn Reson Imaging 17:625-33. 2003
    ....
  71. ncbi Case records of the Massachusetts General Hospital. Case 28-2007. A 68-year-old man with syncope
    James L Januzzi
    Coronary Care Unit, Massachusetts General Hospital, USA
    N Engl J Med 357:1137-45. 2007
  72. ncbi Case records of the Massachusetts General Hospital. Case 11-2008. A 45-year-old man with changes in mental status after liver transplantation
    Jay A Fishman
    Massachusetts General Hospital Transplant Center, Harvard Medical School, Boston, USA
    N Engl J Med 358:1604-13. 2008
  73. ncbi Clinical applications of diffusion MR imaging for acute ischemic stroke
    Albert J Yoo
    Division of Diagnostic and Interventional Neuroradiology, Harvard Medical School, Massachusetts General Hospital, 55 Fruit Street, Gray 241, Boston, MA 02114, USA
    Neuroimaging Clin N Am 21:51-69, vii. 2011
    ..The review focuses on decision-making for intravenous and intra-arterial reperfusion therapies...
  74. ncbi Gadolinium-enhanced CT angiography of the circle of Willis and neck
    John W Henson
    Division of Neuroradiology, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA
    AJNR Am J Neuroradiol 25:969-72. 2004
    ..We report the use of gadolinium as contrast agent for CTA of the head and neck in three patients with contraindications to iodinated contrast agents...
  75. ncbi MRI in treatment of adult gliomas
    John W Henson
    Division of Neuroradiology and Steven E and Catherine Pappas, Center for Neuro Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
    Lancet Oncol 6:167-75. 2005
    ..Thus, as a rapidly expanding sphere of investigation, brain-tumour imaging is producing great excitement. The aim of these new techniques is to aid the identification of more effective treatments...
  76. ncbi Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 38-2003. A 12-year-old girl with fever and coma
    H Shaw Warren
    Pediatric Infectious Disease Unit, Pediatric Service, Massachusetts General Hospital, USA
    N Engl J Med 349:2341-9. 2003
  77. ncbi Diffusion-weighted imaging in acute stroke
    Pamela W Schaefer
    Massachusetts General Hospital, Boston, MA 02114, USA
    Neuroimaging Clin N Am 15:503-30, ix-x. 2005
    ..Also, because predictable progression of diffusion findings occurs during the evolution of ischemia, DWI enables more precise estimation of the time of stroke onset than does conventional imaging...
  78. ncbi Dynamic single-section CT demonstrates reduced cerebral blood flow in acute intracerebral hemorrhage
    Jonathan Rosand
    Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Cerebrovasc Dis 14:214-20. 2002
    ..A gradient of hypoperfusion appears to extend at least 4 mm beyond the hematoma edge and may be time dependent. Whether reduced CBF is associated with perihematoma ischemia requires additional study...
  79. ncbi Biochemical characterization of pediatric brain tumors by using in vivo and ex vivo magnetic resonance spectroscopy
    A Aria Tzika
    Department of Radiology, Massachusetts General Hospital, Harvard Medical School, and Shriners Burns Institute, Boston, 02114, USA
    J Neurosurg 96:1023-31. 2002
    ..Their hypothesis was that ex vivo MR spectroscopy provides a link between in vivo MR spectroscopy and neuropathological analysis...
  80. ncbi Accuracy of CT angiography for the diagnosis of vascular abnormalities causing intraparenchymal hemorrhage in young patients
    Javier M Romero
    Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Emerg Radiol 16:195-201. 2009
    ..MD CTA performed in the Emergency Department provides accurate, rapid and critical presurgical and premedical treatment information in young patients with IPH...
  81. ncbi In vivo 3-T MR spectroscopy in the distinction of recurrent glioma versus radiation effects: initial experience
    James D Rabinov
    Departments of Radiology, Massachusetts General Hospital and Harvard Medical School, 55 Fruit St, Gray 2, Boston, MA 02114, USA
    Radiology 225:871-9. 2002
    ..To determine if 3-T magnetic resonance (MR) spectroscopy allows accurate distinction of recurrent tumor from radiation effects in patients with gliomas of grade II or higher...
  82. ncbi Functional contrast-enhanced CT for evaluation of acute ischemic stroke does not increase the risk of contrast-induced nephropathy
    F O Lima
    Department of Neurology, Stroke Service, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    AJNR Am J Neuroradiol 31:817-21. 2010
    ....
  83. ncbi Normal variation of vertebral artery on CT angiography and its implications for diagnosis of acquired pathology
    Pina C Sanelli
    Department of Radiology, Massachusetts General Hospital, Boston, USA
    J Comput Assist Tomogr 26:462-70. 2002
    ..However, normal variation of the vertebral artery on CT has not been systematically described...
  84. ncbi Influence of availability of clinical history on detection of early stroke using unenhanced CT and diffusion-weighted MR imaging
    Mark E Mullins
    Department of Radiology, Division of Neuroradiology, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA
    AJR Am J Roentgenol 179:223-8. 2002
    ..Whenever possible, relevant clinical history should be made available to physicians interpreting emergency CT scans of the head...
  85. ncbi Neuroimaging of ischemic stroke with CT and MRI: advancing towards physiology-based diagnosis and therapy
    Reza Hakimelahi
    Neuroradiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Expert Rev Cardiovasc Ther 7:29-48. 2009
    ..This article suggests an evidence-based alternative to contemporary acute ischemic stroke therapy...
  86. ncbi Coregistration of head CT comparison studies: assessment of clinical utility
    Dawid Schellingerhout
    Department of Radiology, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA
    Acad Radiol 10:242-8. 2003
    ..It does not detract from the accuracy of interpretation of follow-up studies and tends to decrease intra- and interobserver variability...
  87. ncbi Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 16-2003. A 58-year-old woman with left-sided weakness and a right frontal brain mass
    Robert M Friedlander
    Department of Neurosurgery, Brigham and Women's Hospital, Boston, USA
    N Engl J Med 348:2125-32. 2003
  88. ncbi Neuroimaging in glioma therapy
    John W Henson
    Division of Neuroradiology and Brain Tumor Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Expert Rev Neurother 4:665-71. 2004
    ..This review focuses on some of the unsolved problems in the use of neuroimaging in measuring the response of brain tumors to therapy...
  89. ncbi Quantification of neurons in Alzheimer and control brains with ex vivo high resolution magic angle spinning proton magnetic resonance spectroscopy and stereology
    Leo Ling Cheng
    Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Magn Reson Imaging 20:527-33. 2002
    ..Metabolite ratios measured from the STS area were compared to those from frontal association cortex for their sensitivities in differentiating Alzheimer disease brains from control brains...
  90. ncbi Diffusion-weighted imaging for the evaluation of diffuse axonal injury in closed head injury
    Thierry A G M Huisman
    Department of Radiology, Neuroradiology Section, and MGH NMR Center, Massachusetts General Hospital, Harvard Medical School, Charlestown Boston, USA
    J Comput Assist Tomogr 27:5-11. 2003
    ..The purpose of this work was to compare diffusion-weighted imaging (DWI) with conventional MRI in the detection of shearing injuries in acute closed head injuries...
  91. ncbi Quantitative assessment of core/penumbra mismatch in acute stroke: CT and MR perfusion imaging are strongly correlated when sufficient brain volume is imaged
    Pamela W Schaefer
    Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Stroke 39:2986-92. 2008
    ....

Research Grants20

  1. ADVANCED MR SPECTROSCOPY OF SIV BRAIN INJURY
    Ramon Gonzalez; Fiscal Year: 2001
    ..In other experiments, the animals will be treated after infection. These studies have been simplified since the prior submission. They will begin on Year 02 of the grant. ..
  2. PREDICTING BRAIN TUMOR CHEMOSENSITIVITY BY IN VIVO MRS
    Ramon Gonzalez; Fiscal Year: 2002
    ..abstract_text> ..
  3. MOLECULAR NEUROIMAGING OF AIDS DEMENTIA--ANIMAL MODELS
    Ramon Gonzalez; Fiscal Year: 2002
    ..The relationship of viral infection in the brain to metabolic and pathological abnormalities subsequently observed will be determined. ..
  4. MR Spectroscopy of SIV Brain Injury
    Ramon Gonzalez; Fiscal Year: 2009
    ..Specific Aim 2. Determine the severity of CNS injury by in vivo & ex vivo MRS and immunohistochemistry in different brain regions, and determine the levels of perivascular MPs in those regions. ..