T R Golub

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. pmc A strategy for oligonucleotide microarray probe reduction
    Alena A Antipova
    Center for Genome Research, Whitehead Institute Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Genome Biol 3:RESEARCH0073. 2002
  2. ncbi request reprint Molecular classification of cancer: class discovery and class prediction by gene expression monitoring
    T R Golub
    Whitehead Institute Massachusetts Institute of Technology Center for Genome Research, Cambridge, MA 02139, USA
    Science 286:531-7. 1999
  3. ncbi request reprint Genomic approaches to the pathogenesis of hematologic malignancy
    T R Golub
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Curr Opin Hematol 8:252-61. 2001
  4. pmc Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion
    H A Coller
    Center for Genome Research, Whitehead Institute for Biomedical Research, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 97:3260-5. 2000
  5. pmc Discovering functional relationships between RNA expression and chemotherapeutic susceptibility using relevance networks
    A J Butte
    Children s Hospital Informatics Program and Division of Endocrinology, Department of Medicine, Children s Hospital, 300 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 97:12182-6. 2000
  6. pmc Chemosensitivity prediction by transcriptional profiling
    J E Staunton
    Whitehead/Massachusetts Institute of Technology Center for Genome Research, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 98:10787-92. 2001
  7. pmc Multiclass cancer diagnosis using tumor gene expression signatures
    S Ramaswamy
    Whitehead Institute/Massachusetts Institute of Technology Center for Genome Research, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 98:15149-54. 2001
  8. pmc Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses
    A Bhattacharjee
    Department of Adult Oncology, Dana-Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 98:13790-5. 2001
  9. pmc c-Myc is a critical target for c/EBPalpha in granulopoiesis
    L M Johansen
    Harvard Institutes of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell Biol 21:3789-806. 2001
  10. ncbi request reprint Integrative analysis reveals 53BP1 copy loss and decreased expression in a subset of human diffuse large B-cell lymphomas
    K Takeyama
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, USA
    Oncogene 27:318-22. 2008

Collaborators

Detail Information

Publications12

  1. pmc A strategy for oligonucleotide microarray probe reduction
    Alena A Antipova
    Center for Genome Research, Whitehead Institute Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Genome Biol 3:RESEARCH0073. 2002
    ..A method is presented for reducing the number of probes per gene while maximizing the fidelity to the original array design...
  2. ncbi request reprint Molecular classification of cancer: class discovery and class prediction by gene expression monitoring
    T R Golub
    Whitehead Institute Massachusetts Institute of Technology Center for Genome Research, Cambridge, MA 02139, USA
    Science 286:531-7. 1999
    ....
  3. ncbi request reprint Genomic approaches to the pathogenesis of hematologic malignancy
    T R Golub
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Curr Opin Hematol 8:252-61. 2001
    ....
  4. pmc Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion
    H A Coller
    Center for Genome Research, Whitehead Institute for Biomedical Research, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 97:3260-5. 2000
    ..The genes that displayed an expression profile most similar to endogenous Myc in microarray-based expression profiling of myeloid differentiation models were highly enriched for MYC target genes...
  5. pmc Discovering functional relationships between RNA expression and chemotherapeutic susceptibility using relevance networks
    A J Butte
    Children s Hospital Informatics Program and Division of Endocrinology, Department of Medicine, Children s Hospital, 300 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 97:12182-6. 2000
    ..We discuss the advantages of this methodology over alternative approaches, such as phylogenetic-type tree clustering and self-organizing maps...
  6. pmc Chemosensitivity prediction by transcriptional profiling
    J E Staunton
    Whitehead/Massachusetts Institute of Technology Center for Genome Research, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 98:10787-92. 2001
    ..05) on an independent test set, whereas only 12 of the 232 would be expected to do so by chance. These results suggest that at least for a subset of compounds genomic approaches to chemosensitivity prediction are feasible...
  7. pmc Multiclass cancer diagnosis using tumor gene expression signatures
    S Ramaswamy
    Whitehead Institute/Massachusetts Institute of Technology Center for Genome Research, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 98:15149-54. 2001
    ..Taken together, these results demonstrate the feasibility of accurate, multiclass molecular cancer classification and suggest a strategy for future clinical implementation of molecular cancer diagnostics...
  8. pmc Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses
    A Bhattacharjee
    Department of Adult Oncology, Dana-Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 98:13790-5. 2001
    ..These results suggest that integration of expression profile data with clinical parameters could aid in diagnosis of lung cancer patients...
  9. pmc c-Myc is a critical target for c/EBPalpha in granulopoiesis
    L M Johansen
    Harvard Institutes of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell Biol 21:3789-806. 2001
    ..This is the first report to demonstrate that C/EBPalpha directly affects the level of c-Myc expression and, thus, the decision of myeloid blasts to enter into the granulocytic differentiation pathway...
  10. ncbi request reprint Integrative analysis reveals 53BP1 copy loss and decreased expression in a subset of human diffuse large B-cell lymphomas
    K Takeyama
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, USA
    Oncogene 27:318-22. 2008
    ..These studies highlight the role of 53BP1 copy loss in primary human DLBCLs and the value of integrative analyses in detecting this genetic lesion in human tumors...
  11. pmc Yolk sac angiogenic defect and intra-embryonic apoptosis in mice lacking the Ets-related factor TEL
    L C Wang
    Department of Pediatrics, Harvard Medical School, and Howard Hughes Medical Institute, Boston, MA 02115, USA
    EMBO J 16:4374-83. 1997
    ..Our findings demonstrate that TEL is required for maintenance of the developing vascular network in the yolk sac and for survival of selected cell types within the embryo proper...
  12. pmc Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia
    T R Golub
    Division of Hematology Oncology, Brigham and Women s Hospital, Boston, MA, USA
    Proc Natl Acad Sci U S A 92:4917-21. 1995
    ..The TEL-AML1 fusion also indicates that translocations affecting the AML1 gene can be associated with lymphoid, as well as myeloid, malignancy...