S Z Goldhaber

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi request reprint Cardiology patient pages. Prevention of deep vein thrombosis and pulmonary embolism
    Samuel Z Goldhaber
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Circulation 110:e445-7. 2004
  2. doi request reprint Rationale supporting an "opt-out" policy for pharmacological venous thromboembolism prophylaxis in hospitalized medical patients
    Samuel Z Goldhaber
    Brigham and Women s Hospital, Boston, MA, USA
    J Thromb Thrombolysis 35:371-4. 2013
  3. doi request reprint Venous thromboembolism: epidemiology and magnitude of the problem
    Samuel Z Goldhaber
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, USA
    Best Pract Res Clin Haematol 25:235-42. 2012
  4. doi request reprint Pulmonary embolism and deep vein thrombosis
    Samuel Z Goldhaber
    Brigham and Women s Hospital, Department of Medicine, Harvard Medical School, Cardiovascular Division, Boston, MA 02115, USA
    Lancet 379:1835-46. 2012
  5. ncbi request reprint Enoxaparin monotherapy without oral anticoagulation to treat acute symptomatic pulmonary embolism
    Joshua A Beckman
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Thromb Haemost 89:953-8. 2003
  6. ncbi request reprint Prevention of recurrent idiopathic venous thromboembolism
    Samuel Z Goldhaber
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Circulation 110:IV20-4. 2004
  7. ncbi request reprint Prevention of venous thromboembolism among hospitalized medical patients
    Samuel Z Goldhaber
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    Circulation 111:e1-3. 2005
  8. ncbi request reprint How chest CT for the diagnosis of pulmonary embolism (PE) has changed my professional life: reflections from a PE doctor
    Samuel Z Goldhaber
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Semin Roentgenol 40:8-10. 2005
  9. ncbi request reprint Low rate of venous thromboembolism after craniotomy for brain tumor using multimodality prophylaxis
    Samuel Z Goldhaber
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Chest 122:1933-7. 2002
  10. ncbi request reprint Cardiology patient pages. Treatment of blood clots
    Samuel Z Goldhaber
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Circulation 106:e138-40. 2002

Collaborators

Detail Information

Publications118 found, 100 shown here

  1. ncbi request reprint Cardiology patient pages. Prevention of deep vein thrombosis and pulmonary embolism
    Samuel Z Goldhaber
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Circulation 110:e445-7. 2004
  2. doi request reprint Rationale supporting an "opt-out" policy for pharmacological venous thromboembolism prophylaxis in hospitalized medical patients
    Samuel Z Goldhaber
    Brigham and Women s Hospital, Boston, MA, USA
    J Thromb Thrombolysis 35:371-4. 2013
    ..Ultimately, such an "opt-out" policy might make VTE prophylaxis more effective by avoiding anticoagulation of low thrombosis risk patients who are at high risk of bleeding complications...
  3. doi request reprint Venous thromboembolism: epidemiology and magnitude of the problem
    Samuel Z Goldhaber
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, USA
    Best Pract Res Clin Haematol 25:235-42. 2012
    ....
  4. doi request reprint Pulmonary embolism and deep vein thrombosis
    Samuel Z Goldhaber
    Brigham and Women s Hospital, Department of Medicine, Harvard Medical School, Cardiovascular Division, Boston, MA 02115, USA
    Lancet 379:1835-46. 2012
    ..In this Seminar, we discuss pulmonary embolism and deep vein thrombosis of the legs...
  5. ncbi request reprint Enoxaparin monotherapy without oral anticoagulation to treat acute symptomatic pulmonary embolism
    Joshua A Beckman
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Thromb Haemost 89:953-8. 2003
    ..6 days) (p = 0.001). Following our study we can conclude that extended 3-month treatment with enoxaparin as monotherapy for symptomatic, acute pulmonary embolism is feasible and warrants further study in a large clinical trial...
  6. ncbi request reprint Prevention of recurrent idiopathic venous thromboembolism
    Samuel Z Goldhaber
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Circulation 110:IV20-4. 2004
    ..Avenues of investigation currently being evaluated include measurement of d-dimer levels, examination of residual venous thrombosis on ultrasound, and application of risk nomograms...
  7. ncbi request reprint Prevention of venous thromboembolism among hospitalized medical patients
    Samuel Z Goldhaber
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    Circulation 111:e1-3. 2005
  8. ncbi request reprint How chest CT for the diagnosis of pulmonary embolism (PE) has changed my professional life: reflections from a PE doctor
    Samuel Z Goldhaber
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Semin Roentgenol 40:8-10. 2005
  9. ncbi request reprint Low rate of venous thromboembolism after craniotomy for brain tumor using multimodality prophylaxis
    Samuel Z Goldhaber
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Chest 122:1933-7. 2002
    ..At Brigham and Women's Hospital, VTE after craniotomy for brain tumor is the leading cause of deep vein thrombosis (DVT) and pulmonary embolism (PE) among patients hospitalized for conditions other than VTE...
  10. ncbi request reprint Cardiology patient pages. Treatment of blood clots
    Samuel Z Goldhaber
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Circulation 106:e138-40. 2002
  11. ncbi request reprint Thrombolytic therapy for patients with pulmonary embolism who are hemodynamically stable but have right ventricular dysfunction: pro
    Samuel Z Goldhaber
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Arch Intern Med 165:2197-9; discussion 2204-5. 2005
  12. ncbi request reprint Gastrointestinal complications of dual antiplatelet therapy
    Neelima G Vallurupalli
    Cardiovascular Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    Circulation 113:e655-8. 2006
  13. ncbi request reprint Pulmonary embolism after coronary artery bypass grafting
    Samuel Z Goldhaber
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, Mass 02115, USA
    Circulation 109:2712-5. 2004
  14. ncbi request reprint Acute pulmonary embolism: part I: epidemiology, pathophysiology, and diagnosis
    Samuel Z Goldhaber
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, 75 Francis St, Boston, Mass 02115, USA
    Circulation 108:2726-9. 2003
  15. ncbi request reprint Acute pulmonary embolism: part II: risk stratification, treatment, and prevention
    Samuel Z Goldhaber
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Circulation 108:2834-8. 2003
  16. ncbi request reprint Thrombolysis in submassive pulmonary embolism
    S Z Goldhaber
    Cardiovascular Division, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, Boston, MA, USA
    J Thromb Haemost 2:1473-4; discussion 1474-8. 2004
  17. ncbi request reprint Low intensity warfarin anticoagulation is safe and effective as a long-term venous thromboembolism prevention strategy
    Samuel Z Goldhaber
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    J Thromb Thrombolysis 21:51-2. 2006
    ....
  18. ncbi request reprint DVT Prevention: what is happening in the "real world"?
    Samuel Z Goldhaber
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Semin Thromb Hemost 29:23-31. 2003
    ..We will conclude by posing 10 questions for future research on this topic...
  19. ncbi request reprint Epidemiology of pulmonary embolism
    S Z Goldhaber
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Semin Vasc Med 1:139-46. 2001
    ..The two most common genetic mutations that predispose to VTE are the factor V Leiden and the prothrombin gene. VTE can be precipitated by oral contraceptives, pregnancy, or hormone replacement therapy...
  20. ncbi request reprint Pulmonary embolism
    Samuel Z Goldhaber
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Lancet 363:1295-305. 2004
    ..After hospital discharge, prophylaxis should continue for about a month for patients at high risk of thromboembolism...
  21. ncbi request reprint Cardiology patient pages. Pulmonary embolism and deep vein thrombosis
    Samuel Z Goldhaber
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Circulation 106:1436-8. 2002
  22. ncbi request reprint Modern treatment of pulmonary embolism
    S Z Goldhaber
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Eur Respir J Suppl 35:22s-27s. 2002
    ..Fortunately the current tools for risk stratification provide an "early window" for prognostication and can help the coordination of a definitive treatment plan with optimal results...
  23. ncbi request reprint Treatment of pulmonary thromboembolism
    S Z Goldhaber
    Department of Medicine Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Intern Med 38:620-5. 1999
    ..Finally, the availability of low molecular weight heparins broadens our options for pharmacologic management...
  24. doi request reprint Apixaban versus enoxaparin for thromboprophylaxis in medically ill patients
    Samuel Z Goldhaber
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    N Engl J Med 365:2167-77. 2011
    ..We hypothesized that extended prophylaxis with apixaban would be safe and more effective than short-term prophylaxis with enoxaparin...
  25. doi request reprint Risk factors for venous thromboembolism
    Samuel Z Goldhaber
    Harvard Medical School, Venous Thromboembolism Research Group, Cardiovascular Division, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Am Coll Cardiol 56:1-7. 2010
    ..Because approximately 3 of every 4 pulmonary embolism and DVT events occur outside the hospital setting, patients should also be assessed for persistent high-risk of VTE at the time of hospital discharge...
  26. ncbi request reprint Diagnosis of deep venous thrombosis
    S Z Goldhaber
    Cardiovascular Division, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Clin Cornerstone 2:29-37. 2000
    ..Once DVT is suspected, a workup can proceed rapidly and accurately to resolve the diagnostic issue...
  27. ncbi request reprint Diagnosis of pulmonary embolism
    S Z Goldhaber
    Cardiovascular Division, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Clin Cornerstone 2:38-46. 2000
    ..With a 3-stage approach consisting of (1) clinical evaluation; (2) nonimaging laboratory tests; and (3) imaging tests, PE can often be quickly detected with a definitive evaluation...
  28. ncbi request reprint Management of deep venous thrombosis and pulmonary embolism
    S Z Goldhaber
    Cardiovascular Division, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Clin Cornerstone 2:47-58; quiz 59-64. 2000
    ..Among patients with massive DVT or hemodynamically unstable PE, thrombolysis, thrombectomy, and embolectomy (often performed in an interventional angiography laboratory) are being used with increasing skill and improved outcomes...
  29. doi request reprint Advanced treatment strategies for acute pulmonary embolism, including thrombolysis and embolectomy
    S Z Goldhaber
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Thromb Haemost 7:322-7. 2009
    ..Our 'new approach' uses advanced treatment strategies in addition to anticoagulation for those pulmonary embolism patients deemed to be at high risk for a poor outcome...
  30. ncbi request reprint New onset of venous thromboembolism among hospitalized patients at Brigham and Women's Hospital is caused more often by prophylaxis failure than by withholding treatment
    S Z Goldhaber
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Chest 118:1680-4. 2000
    ..Therefore, among hospitalized patients, the development of VTE is thought to occur in the context of omitted prophylaxis...
  31. ncbi request reprint Preventing pulmonary embolism and deep vein thrombosis: a 'call to action' for vascular medicine specialists
    S Z Goldhaber
    Cardiovascular Division, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02115, USA
    J Thromb Haemost 5:1607-9. 2007
  32. ncbi request reprint Thrombolysis in pulmonary embolism: a debatable indication
    S Z Goldhaber
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston 02115, USA
    Thromb Haemost 86:444-51. 2001
    ..Future clinical trials will require multicenter collaboration and focus on clinically relevant endpoints such as reduction of mortality and recurrent venous thromboembolism...
  33. ncbi request reprint Echocardiography in the management of pulmonary embolism
    Samuel Z Goldhaber
    Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Ann Intern Med 136:691-700. 2002
    ..Further research will clarify and define more precisely the utility and limitations of echocardiography in the management of pulmonary embolism...
  34. ncbi request reprint Acute pulmonary embolism: risk stratification
    Samuel Z Goldhaber
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Pathophysiol Haemost Thromb 35:153-6. 2006
    ..When high-risk patients are identified,they can be triaged for urgent or emergent therapy, usually prior to developing overt hypotension and cardiogenic shock...
  35. ncbi request reprint Unsolved issues in the treatment of pulmonary embolism
    S Z Goldhaber
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Thromb Res 103:V245-55. 2001
    ..Despite the high rate of recurrent venous thrombosis after discontinuation of anticoagulation, there are currently insufficient data to recommend indefinite warfarin therapy...
  36. ncbi request reprint Hormonal factors and risk of recurrent venous thrombosis: the prevention of recurrent venous thromboembolism trial
    M Cushman
    Department of Medicine, University of Vermont, Burlington, VT 05446, USA
    J Thromb Haemost 4:2199-203. 2006
    ..In some but not all studies, men with venous thrombosis had a higher risk of recurrence than women. Information on women with initial hormone-related thrombosis is scant...
  37. ncbi request reprint Venous thromboembolism in patients with active cancer
    Ali Seddighzadeh
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Thromb Haemost 98:656-61. 2007
    ..Future studies should focus on ways to improve implementation of prophylaxis in cancer patients and to further define the indications, efficacy, and safety of inferior vena caval filters in this population...
  38. ncbi request reprint D-dimer, factor VIII coagulant activity, low-intensity warfarin and the risk of recurrent venous thromboembolism
    S Shrivastava
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Boston, MA, USA
    J Thromb Haemost 4:1208-14. 2006
    ..Elevated plasma D-dimer and factor VIII coagulant activity (FVIIIc) may be associated with the risk of recurrent venous thromboembolism (VTE)...
  39. ncbi request reprint Upper-extremity deep vein thrombosis: a prospective registry of 592 patients
    Hylton V Joffe
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Circulation 110:1605-11. 2004
    ..Upper-extremity deep vein thrombosis (UEDVT) occurs spontaneously or sometimes develops as a complication of pacemaker use, long-term use of a central venous catheter (CVC), or cancer...
  40. ncbi request reprint Double trouble for 2,609 hospitalized medical patients who developed deep vein thrombosis: prophylaxis omitted more often and pulmonary embolism more frequent
    Gregory Piazza
    Cardiovascular Division, Beth Israel Deaconess Medical Center, 1 Deaconess Rd, Baker 4, Boston, MA 02215, USA
    Chest 132:554-61. 2007
    ..Hospitalized patients with medical illness are especially susceptible to the development of venous thromboembolism (VTE)...
  41. ncbi request reprint Prospective study of moderate alcohol consumption and risk of peripheral arterial disease in US male physicians
    C A Camargo
    Division of Preventive Medicine, Brigham and Women s Hospital, Boston, MA 02215 1204, USA
    Circulation 95:577-80. 1997
    ..Moderate alcohol consumption decreases the risk of coronary heart disease, but its relation to peripheral arterial disease (PAD) is uncertain...
  42. ncbi request reprint Abbreviated hospitalization for deep venous thrombosis with the use of ardeparin
    S Z Goldhaber
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Arch Intern Med 158:2325-8. 1998
    ..However, this low-molecular-weight heparin has not been previously evaluated in a randomized controlled trial for treatment of established acute deep venous thrombosis...
  43. ncbi request reprint Time trends in warfarin-associated hemorrhage
    Nils Kucher
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Cardiol 94:403-6. 2004
    ..The proportion of patients with major and intracranial bleeding increased from 20.2% and 1.9%, respectively, in the first time period, to 33.3% and 7.8%, respectively, in the second...
  44. ncbi request reprint Thrombolytic therapy in pulmonary embolism
    S Z Goldhaber
    Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
    Semin Vasc Med 1:213-20. 2001
    ..7% in clinical trials up to approximately 3.0% in a large registry...
  45. ncbi request reprint Effects of random allocation to vitamin E supplementation on the occurrence of venous thromboembolism: report from the Women's Health Study
    Robert J Glynn
    Division of Preventive Medicine, Brigham and Women s Hospital, 900 Commonwealth Ave E, Boston, MA 02215 1204, USA
    Circulation 116:1497-503. 2007
    ..Supplementation with vitamin E may antagonize vitamin K in healthy adults, but it is unclear whether intake of vitamin E decreases the risk of venous thromboembolism (VTE)...
  46. ncbi request reprint Thrombosis during pregnancy and the postpartum period
    Andra H James
    Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC 27710 and Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Am J Obstet Gynecol 193:216-9. 2005
    ..To describe the circumstances surrounding deep vein thrombosis among pregnant or postpartum patients enrolled in a large multicenter registry...
  47. ncbi request reprint Chest CT assessment following thrombolysis or surgical embolectomy for acute pulmonary embolism
    Florian Kipfmueller
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Vasc Med 10:85-9. 2005
    ..33). Reconstructed 4-chamber views on chest CT provide noninvasive imaging of right ventricular enlargement and permit dynamic assessment of the right ventricular response to thrombolysis and embolectomy in patients with acute PE...
  48. ncbi request reprint Venous thromboembolism in patients undergoing surgery: low rates of prophylaxis and high rates of filter insertion
    Ali Seddighzadeh
    Cardiovascular Division, Brigham and Women s Hospital Boston, MA 02115, USA
    Thromb Haemost 98:1220-5. 2007
    ..Future studies should focus on devising mechanisms to improve implementation of prophylaxis and investigate the long-term safety and efficacy of IVC filters in surgical patients...
  49. ncbi request reprint Electronic alerts to prevent venous thromboembolism among hospitalized patients
    Nils Kucher
    Department of Medicine, Cardiovascular Division, Harvard Medical School and Brigham and Women s Hospital, Boston, MA 02115, USA
    N Engl J Med 352:969-77. 2005
    ..We hypothesized that the use of a computer-alert program to encourage prophylaxis might reduce the frequency of deep-vein thrombosis among high-risk hospitalized patients...
  50. ncbi request reprint Effect of low-dose aspirin on the occurrence of venous thromboembolism: a randomized trial
    Robert J Glynn
    Brigham and Women s Hospital, Harvard Medical School, and Harvard School of Public Health, Boston, Massachusetts 02215, USA
    Ann Intern Med 147:525-33. 2007
    ..Short-term aspirin therapy can lower the risk for venous thromboembolism (VTE) in high-risk patients, but whether the long-term use of low-dose aspirin reduces risk in healthy adults is uncertain...
  51. ncbi request reprint Efficacy and safety of fixed low-dose dalteparin in preventing venous thromboembolism among obese or elderly hospitalized patients: a subgroup analysis of the PREVENT trial
    Nils Kucher
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Arch Intern Med 165:341-5. 2005
    ..We were concerned that a fixed rather than a weight-based dosing regimen of dalteparin sodium to prevent venous thromboembolism (VTE) might result in decreased efficacy in obese patients and decreased safety in elderly patients...
  52. ncbi request reprint Modern surgical treatment of massive pulmonary embolism: results in 47 consecutive patients after rapid diagnosis and aggressive surgical approach
    Marzia Leacche
    Division of Cardiac Surgery, and Cardiovascular Division, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    J Thorac Cardiovasc Surg 129:1018-23. 2005
    ....
  53. ncbi request reprint Prognostic role of brain natriuretic peptide in acute pulmonary embolism
    Nils Kucher
    Cardiovascular Division, Brigham and Women s Hospital, 75 Francis St, Harvard Medical School, Boston, Mass 02115, USA
    Circulation 107:2545-7. 2003
    ..Rapid, noninvasive, and accurate prognostic assessment with an inexpensive cardiac biomarker is an appealing approach for patients with acute pulmonary embolism (PE)...
  54. ncbi request reprint Comparison of efficacy, safety, and cost of low-molecular-weight heparin with continuous-infusion unfractionated heparin for initiation of anticoagulation after mechanical prosthetic valve implantation
    John Fanikos
    Cardiovascular Division, The Department of Pharmacy, and Center for Clinical Excellence, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Am J Cardiol 93:247-50. 2004
    ..The patients who received low-molecular-weight heparin had a shorter length of stay and decreased postoperative costs compared with the control subjects receiving unfractionated heparin...
  55. ncbi request reprint Cost implications of low molecular weight heparins as prophylaxis following total hip and knee replacement
    G K Bell
    Charles River Associates, Inc, Boston, MA, USA
    Vasc Med 6:23-9. 2001
    ..In conclusion, LMWH has the potential to offer several short- and long-term cost advantages compared with warfarin, mostly due to lower test costs associated with prophylaxis and reduced complication rates...
  56. ncbi request reprint Prognostic role of echocardiography among patients with acute pulmonary embolism and a systolic arterial pressure of 90 mm Hg or higher
    Nils Kucher
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Arch Intern Med 165:1777-81. 2005
    ..The prognostic role of echocardiographic right ventricular (RV) dysfunction for predicting mortality in patients with acute pulmonary embolism and a preserved systemic arterial pressure remains controversial...
  57. ncbi request reprint Major bleeding complications in a specialized anticoagulation service
    John Fanikos
    Department of Pharmacy, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Cardiol 96:595-8. 2005
    ..32 bleeds/100 patient-years of coverage. Of the 12 bleeding events, 5 (42%) were intracranial hemorrhages. The average hospitalization cost per patient was dollar 15,988, and the average length of hospitalization was 6.0 days...
  58. ncbi request reprint Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 17-2004. A 42-year-old woman with cardiac arrest several weeks after an ankle fracture
    Samuel Z Goldhaber
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Boston, USA
    N Engl J Med 350:2281-90. 2004
  59. doi request reprint Once daily enoxaparin for outpatient treatment of acute venous thromboembolism: a case-control study
    Melkon Hacobian
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Clin Appl Thromb Hemost 16:21-5. 2010
    ..5 mg/kg once daily versus enoxaparin 1.0 mg/kg twice daily as a bridge to warfarin in outpatients with acute venous thromboembolism...
  60. ncbi request reprint Massive pulmonary embolism
    Nils Kucher
    Cardiovascular Division, Department of Medicine, University Hospital Zurich, Zurich, Switzerland
    Circulation 113:577-82. 2006
    ..We explored how often adjunctive therapies, particularly thrombolysis and inferior vena caval (IVC) filter placement, were performed and how these therapies affected the clinical outcome of patients with massive PE...
  61. ncbi request reprint Thrombolysis for pulmonary embolism
    Samuel Z Goldhaber
    Harvard Medical School, Boston, MA 02115, USA
    N Engl J Med 347:1131-2. 2002
  62. ncbi request reprint Prognostic significance of troponin elevation and right ventricular enlargement in acute pulmonary embolism
    Tudor Scridon
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Am J Cardiol 96:303-5. 2005
    ..Patients with elevated troponin and right ventricular enlargement are at significantly greater risk for death after PE than patients with only 1 or with neither adverse prognostic marker...
  63. ncbi request reprint Clinically significant venous thromboembolism after gynecologic surgery
    J O Schorge
    Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Reprod Med 44:669-73. 1999
    ..To review the incidence and outcome of clinically significant venous thromboembolism (VTE) following gynecologic surgery in a population receiving provider-specified prophylaxis...
  64. ncbi request reprint Optimizing anticoagulant therapy in the management of pulmonary embolism
    S Z Goldhaber
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Semin Thromb Hemost 25:129-33. 1999
    ..Recognition of potential causes of excessive anticoagulation and the use of self-monitoring by patients may improve the efficacy and safety of long-term warfarin administration...
  65. ncbi request reprint Extended enoxaparin monotherapy for acute symptomatic pulmonary embolism
    Nils Kucher
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Vasc Med 10:251-6. 2005
    ..217). In patients with acute symptomatic PE, extended enoxaparin monotherapy is feasible and warrants further investigation in a large clinical trial...
  66. ncbi request reprint Acute pulmonary embolectomy: a contemporary approach
    Lishan Aklog
    Department of Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Circulation 105:1416-9. 2002
    ....
  67. ncbi request reprint Predictors of major hemorrhage following fibrinolysis for acute pulmonary embolism
    Karen Fiumara
    Department of Pharmacy, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Cardiol 97:127-9. 2006
    ..4 to 1,410.9, p < 0.001), cancer (OR 16.0, 95% CI 3.2 to 80, p = 0.004), diabetes mellitus (OR 9.6, 95% CI 1.7 to 54, p = 0.010), and elevated international normalized ratio before fibrinolysis (OR 5.8, 95% CI 1.5 to 22, p = 0.012)...
  68. doi request reprint Gastrointestinal complications after 3 months of dual antiplatelet therapy for drug-eluting stents as assessed by wireless capsule endoscopy
    Ali Seddighzadeh
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Clin Appl Thromb Hemost 15:171-6. 2009
    ..Future studies should expand on our observations to determine whether prophylaxis with proton pump inhibitors is warranted...
  69. doi request reprint Routine pelvic and lower extremity CT venography in patients undergoing pulmonary CT angiography
    Andetta R Hunsaker
    Department of Radiology, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    AJR Am J Roentgenol 190:322-6. 2008
    ..The purpose of our study was to assess the utility of performing routine pelvic and lower extremity CT venography (CTV) along with pulmonary CT angiography (CTA) in all patients evaluated for pulmonary embolism...
  70. ncbi request reprint Chronic obstructive pulmonary disease and deep vein thrombosis: a prevalent combination
    Ranjith Shetty
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    J Thromb Thrombolysis 26:35-40. 2008
    ..Patients with chronic obstructive pulmonary disease (COPD) are at increased risk for venous thromboembolism (VTE). We analyzed a large US deep vein thrombosis (DVT) registry to explore the profile of patients with COPD and VTE...
  71. ncbi request reprint Few predictors of massive deep vein thrombosis
    Hylton V Joffe
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Thromb Haemost 94:986-90. 2005
    ..02-1.34) was the only independent predictor of massive DVT. Thrombus propagation from the femoropopliteal system cannot be reliably predicted using demographic or clinical characteristics...
  72. ncbi request reprint International normalized ratio increase before warfarin-associated hemorrhage: brief and subtle
    Nils Kucher
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Arch Intern Med 164:2176-9. 2004
    ..To determine the relationship between serial international normalized ratios (INRs) in patients who have been undergoing long-term anticoagulation and the onset of warfarin-associated bleeding complications...
  73. ncbi request reprint Normal D-dimer levels in emergency department patients suspected of acute pulmonary embolism
    Kelly L Dunn
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Am Coll Cardiol 40:1475-8. 2002
    ....
  74. ncbi request reprint A prospective study of risk factors for pulmonary embolism in women
    S Z Goldhaber
    Channing Laboratory, Boston, Mass, USA
    JAMA 277:642-5. 1997
    ..To investigate risk factors for pulmonary embolism in women...
  75. doi request reprint Deep-vein thrombosis in the elderly
    Gregory Piazza
    Department of Medicine, Cardiovascular Division, Beth Israel Deaconess Medical Center, Harvard Medical School, 1 Deaconess Road, Boston, MA 02215, USA
    Clin Appl Thromb Hemost 14:393-8. 2008
    ..Diagnosis can present a challenge because typical deep-vein thrombosis symptoms may be absent. Fewer than 50% of elderly patients with deep-vein thrombosis had received any venous thromboembolism prophylaxis...
  76. doi request reprint Pulmonary embolism in heart failure
    Gregory Piazza
    Cardiovascular Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    Circulation 118:1598-601. 2008
  77. ncbi request reprint Medication errors associated with anticoagulant therapy in the hospital
    John Fanikos
    Department of Pharmacy, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02215, USA
    Am J Cardiol 94:532-5. 2004
    ..2% of patients required medical intervention and 1.5% needed prolonged hospitalization. Medication errors frequently occur with anticoagulant therapy in hospitalized patients...
  78. ncbi request reprint The contribution of the subjective component of the Canadian Pulmonary Embolism Score to the overall score in emergency department patients
    Christopher Kabrhel
    Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Acad Emerg Med 12:915-20. 2005
    ..However, research suggests that subjective gestalt performs similarly to the CPES, and the influence of the subjective question on the predictive value of the CPES is not clear...
  79. pmc Physician alerts to prevent symptomatic venous thromboembolism in hospitalized patients
    Gregory Piazza
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Circulation 119:2196-201. 2009
    ....
  80. pmc Prospective study of BMI and the risk of pulmonary embolism in women
    Christopher Kabrhel
    Department of Emergency Medicine, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, USA
    Obesity (Silver Spring) 17:2040-6. 2009
    ..Increasing BMI has a strong, linear association with the development of PE in women. Clinicians should consider BMI when assessing the risk of PE in their patients...
  81. ncbi request reprint Cardiac decortication (epicardiectomy) for occult constrictive cardiac physiology after left extrapleural pneumonectomy
    John G Byrne
    Cardiac Surgery, Brigham and Women s Hospital, 75 Francis Street, Boston, MA, USA
    Chest 122:2256-9. 2002
    ..When patients present with dyspnea, hepatojugular reflux, and peripheral edema refractory to diuretics, constrictive cardiac physiology should be considered in the differential diagnosis, even in the absence of parietal pericardium...
  82. doi request reprint Long-term complications of medical patients with hospital-acquired venous thromboembolism
    John Fanikos
    Department of Pharmacy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Thromb Haemost 102:688-93. 2009
    ..These VTE complications would be reduced by more than half with universal thromboprophylaxis. Further efforts should focus on improving VTE prophylaxis utilisation...
  83. doi request reprint Fibrinolysis for acute pulmonary embolism
    Gregory Piazza
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Vasc Med 15:419-28. 2010
    ....
  84. ncbi request reprint Cost analysis of "bridging therapy" with low-molecular-weight heparin versus unfractionated heparin during temporary interruption of chronic anticoagulation
    Stacey L Amorosi
    Innovus Research Inc, Medford, Massachusetts 02115, USA
    Am J Cardiol 93:509-11. 2004
    ..For surgeries requiring an overnight stay, bridging costs are estimated to be 672, 933, and 3,816 US dollars, respectively, for each of these strategies...
  85. doi request reprint Adherence to pharmacological thromboprophylaxis orders in hospitalized patients
    John Fanikos
    Department of Pharmacy, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Med 123:536-41. 2010
    ..Our goals were to determine which strategy demonstrated the best adherence in terms of timing and frequency of dose administration, and to determine reasons for ordered heparin not being administered...
  86. ncbi request reprint Shortness of breath in the postoperative patient
    Haritha Challapalli
    Division of Emergency Medicine, Harvard Medical School, Boston, Massachusetts, USA
    J Emerg Med 27:171-7. 2004
  87. ncbi request reprint Comparison of a single end point to determine optimal initial warfarin dosing (5 mg versus 10 mg) for venous thromboembolism
    Rene Quiroz
    Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA
    Am J Cardiol 98:535-7. 2006
    ..69). These results should provide clinicians with increased warfarin dosing options in patients presenting with acute venous thromboembolism...
  88. ncbi request reprint Heparin-induced thrombocytopenia (HIT): clinical and economic outcomes
    Steven Baroletti
    Department of Pharmacy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Thromb Haemost 100:1130-5. 2008
    ..Prospective controlled trials need to be conducted to determine the optimal strategy to reduce the frequency of HIT...
  89. ncbi request reprint Prescription of fondaparinux in hospitalised patients
    Steven Baroletti
    Department of Pharmacy, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Thromb Haemost 101:1091-4. 2009
    ..Fondaparinux warrants further evaluation in patients with HIT or suspected HIT. In the meantime, its off-label use may exceed its use for FDA-approved indications...
  90. pmc Prospective study of ABO blood type and the risk of pulmonary embolism in two large cohort studies
    Brian M Wolpin
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Thromb Haemost 104:962-71. 2010
    ..04). In two large, prospective cohorts, ABO blood type was significantly associated with the risk of idiopathic and non-idiopathic PE, with even greater risk for idiopathic PE among current and past smokers with non-O blood type...
  91. doi request reprint Deep vein thrombosis in orthopedic surgery
    Marcella Calfon
    Department of Medicine, Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston Massachusetts, USA
    Clin Appl Thromb Hemost 15:512-6. 2009
    ..In conclusion, despite having fewer comorbid conditions, orthopedic patients with deep vein thrombosis remain particularly vulnerable to calf deep vein thrombosis. Rates of venous thromboembolism prophylaxis were inadequate...
  92. ncbi request reprint A prospective registry of 5,451 patients with ultrasound-confirmed deep vein thrombosis
    Samuel Z Goldhaber
    The Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Am J Cardiol 93:259-62. 2004
    ..Of the 2,726 patients who had their DVT diagnosed while in the hospital, only 1,147 (42%) received prophylaxis within 30 days before diagnosis...
  93. doi request reprint Physician alerts to prevent venous thromboembolism
    Gregory Piazza
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Thromb Thrombolysis 30:1-6. 2010
    ..In this review article, we discuss decision support strategies for improving VTE prevention during hospitalization and at the time of discharge...
  94. pmc Venous thromboembolic events in hospitalised medical patients
    Gregory Piazza
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Thromb Haemost 102:505-10. 2009
    ..The number of VTE-related events would be halved with universal thromboprophylaxis. Further efforts focused on improving VTE prevention strategies in hospitalised medical patients are warranted...
  95. ncbi request reprint Point-of-care (POC) versus central laboratory instrumentation for monitoring oral anticoagulation
    David M Dorfman
    Department of Pathology, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Vasc Med 10:23-7. 2005
    ..Instead, a predefined cut-off range for high INR values generated by POC instruments should mandate confirmatory testing with central laboratory instrumentation...
  96. ncbi request reprint High utilization rate of vena cava filters in deep vein thrombosis
    Michael R Jaff
    Massachusetts General Hospital, 55 Fruit Street, Yawkey Center for Outpatient Care, Room 5938, Boston, Massachusetts 02114, USA
    Thromb Haemost 93:1117-9. 2005
    ..Many of these patients may have warranted less invasive methods of venous thromboembolism prophylaxis. Improved physician education regarding mechanical and pharmacologic prophylaxis alternatives might reduce the use of IVCFs...
  97. ncbi request reprint Time-resolved MR angiography: a primary screening examination of patients with suspected pulmonary embolism and contraindications to administration of iodinated contrast material
    Hale Ersoy
    Cardiovascular Imaging Section, Department of Radiology, Brigham and Women s Hospital and Harvard Medical School, 75 Francis St, ASB I L1 004, Boston, MA 02115, USA
    AJR Am J Roentgenol 188:1246-54. 2007
    ..The purpose of this study was to evaluate the efficiency and reproducibility of a single-breath-hold time-resolved 3D MR angiographic technique in the diagnosis of pulmonary embolism...
  98. ncbi request reprint Long-term, low-intensity warfarin therapy for the prevention of recurrent venous thromboembolism
    Paul M Ridker
    Center for Cardiovascular Disease Prevention and the Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston 02215, USA
    N Engl J Med 348:1425-34. 2003
    ..0 and 3.0. However, for long-term management, no therapeutic agent has shown an acceptable benefit-to-risk ratio...
  99. ncbi request reprint The probability of pulmonary embolism is a function of the diagnoses considered most likely before testing
    Christopher Kabrhel
    Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Acad Emerg Med 13:471-4. 2006
    ....
  100. ncbi request reprint Clinical gestalt and the diagnosis of pulmonary embolism: does experience matter?
    Christopher Kabrhel
    Department of Emergency Medicine, Massachusetts General Hospital, 55 Fruit St, Clinics Building 115, Boston, MA 02114, USA
    Chest 127:1627-30. 2005
    ....
  101. ncbi request reprint Relationship between CT coronary angiography and stress perfusion imaging in patients with suspected ischemic heart disease assessed by integrated PET-CT imaging
    Marcelo F Di Carli
    Division of Nuclear Medicine PET, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Nucl Cardiol 14:799-809. 2007
    ..We examined the value of CTA to identify the presence of ischemia, as determined by stress perfusion imaging, using integrated positron emission tomography (PET)-CT imaging...