Affiliation: Massachusetts General Hospital
Cox A, Saunders D, Kelsey P, Conway A, Tesmenitsky Y, Marchini J, et al
. S-nitrosothiol signaling regulates liver development and improves outcome following toxic liver injury. Cell Rep. 2014;6:56-69 pubmed publisher
..These studies demonstrate that GSNOR inhibitors will be beneficial therapeutic candidates for treating liver injury. ..
Goessling W, Massaro J, Vasan R, D Agostino R, Ellison R, Fox C. Aminotransferase levels and 20-year risk of metabolic syndrome, diabetes, and cardiovascular disease. Gastroenterology. 2008;135:1935-44, 1944.e1 pubmed publisher
..Both normal and increased levels of ALT are associated with long-term development of multiple metabolic disorders. These results indicate the potential for ALT values as biomarkers for the risk of metabolic disease. ..
Cox A, Goessling W. The lure of zebrafish in liver research: regulation of hepatic growth in development and regeneration. Curr Opin Genet Dev. 2015;32:153-61 pubmed publisher
Goessling W, North T. EnaBILEing Growth in the Fetal Liver. Cell Stem Cell. 2016;18:427-8 pubmed publisher
..Sigurdsson et al. (2016) provide justification for transient fetal liver residence, where select bile acid composition, derived from mother and embryo, provides a protective environment, enabling rapid stem cell expansion. ..
Nissim S, Sherwood R, Wucherpfennig J, Saunders D, Harris J, Esain V, et al
. Prostaglandin E2 regulates liver versus pancreas cell-fate decisions and endodermal outgrowth. Dev Cell. 2014;28:423-37 pubmed publisher
..This work provides in vivo evidence that PGE2 may act as a morphogen to regulate cell-fate decisions and outgrowth of the embryonic endodermal anlagen. ..
Carroll K, Esain V, Garnaas M, Cortes M, Dovey M, Nissim S, et al
. Estrogen defines the dorsal-ventral limit of VEGF regulation to specify the location of the hemogenic endothelial niche. Dev Cell. 2014;29:437-53 pubmed publisher
..Together, these data suggest that yolk-derived E2 sets the ventral boundary of hemogenic vascular niche specification by antagonizing the dorsal-ventral regulatory limits of VEGF. ..
Liu L, Alexa K, Cortes M, Schatzman Bone S, Kim A, Mukhopadhyay B, et al
. Cannabinoid receptor signaling regulates liver development and metabolism. Development. 2016;143:609-22 pubmed publisher
..Our work describes a novel developmental role for EC signaling, whereby Cnr-mediated regulation of Srebfs and methionine metabolism impacts liver development and function. ..
Nissim S, Weeks O, Talbot J, Hedgepeth J, Wucherpfennig J, Schatzman Bone S, et al
. Iterative use of nuclear receptor Nr5a2 regulates multiple stages of liver and pancreas development. Dev Biol. 2016;418:108-123 pubmed publisher
..These findings define critical iterative and pleiotropic roles for Nr5a2 at distinct stages of pancreas and liver organogenesis, and provide novel perspectives for interpreting the role of Nr5a2 in disease. ..
Cox A, Tsomides A, Kim A, Saunders D, Hwang K, Evason K, et al
. Selenoprotein H is an essential regulator of redox homeostasis that cooperates with p53 in development and tumorigenesis. Proc Natl Acad Sci U S A. 2016;113:E5562-71 pubmed publisher
..Overall, our findings establish that seph regulates redox homeostasis and suppresses DNA damage. We hypothesize that SepH deficiency may contribute to the increased cancer risk observed in cohorts with low selenium levels. ..