Research Topics
Species | J N GlickmanSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
| Collaborators
|
Detail Information
Publications
Interinstitutional variability and effect of tissue fixative on the interpretation of a Barrett cytokeratin 7/20 immunoreactivity pattern in Barrett esophagusJonathan N Glickman
Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Hum Pathol 36:58-65. 2005..Nevertheless, specific criteria for interpretation of CK7/20 staining can be successfully applied between institutions and need to be developed before use of this technique in clinical practice...
Multilayered epithelium in a rat model and human Barrett's esophagus: similar expression patterns of transcription factors and differentiation markersXiaoxin Chen
Cancer Research Program, Julius L, Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, 700 George Street, Durham, NC 27707, USA
BMC Gastroenterol 8:1. 2008..Invest. 2004;84:753-765). The purpose of this study was to compare the phenotype of rat MLE with human MLE, in order to gain insight into the nature of MLE and its potential role in the development of BE...- Cyclooxygenase-2 overexpression is common in serrated and non-serrated colorectal adenoma, but uncommon in hyperplastic polyp and sessile serrated polyp/adenomaTakako Kawasaki
Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, USA
BMC Cancer 8:33. 2008..Therefore, we hypothesized that COX-2 may play a less important role in the serrated pathway... - Mucin core peptide expression can help differentiate Barrett's esophagus from intestinal metaplasia of the stomachJonathan N Glickman
Department of Pathology, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
Am J Surg Pathol 27:1357-65. 2003..Columnar epithelium in the "normal" gastric cardia has a partially intestinalized phenotype and, as a result, may represent an early form of metaplastic epithelium... - Mucin core polypeptide expression in the progression of neoplasia in Barrett's esophagusJonathan N Glickman
Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Hum Pathol 37:1304-15. 2006..Alterations in MUC expression occur in the progression of dysplasia in BE. However, none of these markers helps identify a subgroup of patients at increased risk for neoplasia... - Pediatric patients with untreated ulcerative colitis may present initially with unusual morphologic findingsJonathan N Glickman
Department of Pathology, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
Am J Surg Pathol 28:190-7. 2004..Therefore, the objectives of this study were to determine the clinical and pathologic features of new-onset UC in children and to compare the initial presentation of UC in this group with a control group of adults... - GastritisJ N Glickman
Department of Pathology, Brigham and Women s Hospital and Harvard University School of Medicine, Boston, Massachusetts 02115, USA
Gastrointest Endosc Clin N Am 11:717-40, vii. 2001..Other major causes of gastritis include celiac disease, allergic disorders, and Crohn's disease. The distinctive clinical, endoscopic, and histologic features of these disorders are discussed... - Morphology of the cardia and significance of carditis in pediatric patientsJonathan N Glickman
Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Am J Surg Pathol 26:1032-9. 2002.... - Phenotypic characteristics of a distinctive multilayered epithelium suggests that it is a precursor in the development of Barrett's esophagusJ N Glickman
Departments of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Am J Surg Pathol 25:569-78. 2001..The mucosal gland duct epithelium may contain progenitor cells that can give rise to ME... - Phenotype of Barrett's esophagus and intestinal metaplasia of the distal esophagus and gastroesophageal junction: an immunohistochemical study of cytokeratins 7 and 20, Das-1 and 45 MIJ N Glickman
Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
Am J Surg Pathol 25:87-94. 2001..This may indicate that IM in LSBE, SSBE and at the GEJ have similar biologic properties. Based on our data, SSBE and IMGEJ cannot be distinguished on the basis of their immunophenotype... - Four-gene expression ratio test for survival in patients undergoing surgery for mesotheliomaGavin J Gordon
Department of Surgery, Division of Thoracic Surgery, Harvard Medical School and Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
J Natl Cancer Inst 101:678-86. 2009..In this study, we investigated the predictive value and technical assay performance of this test in patients with malignant pleural mesothelioma... - Expression of p53-related protein p63 in the gastrointestinal tract and in esophageal metaplastic and neoplastic disordersJ N Glickman
Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Hum Pathol 32:1157-65. 2001..These data also indicate that multilayered epithelium is phenotypically similar to, and may share a lineage relationship with, mucosal gland duct epithelium... - An unusual mixed tumor of the pancreas: sonographic and MDCT featuresKoenraad J Mortele
Division of Abdominal Imaging and Intervention, Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
JOP 10:204-8. 2009..Mixed tumors of the pancreas are exceedingly rare... - Transcriptome sequencing of malignant pleural mesothelioma tumorsDavid J Sugarbaker
International Mesothelioma Program, Division of Thoracic Surgery, Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 105:3521-6. 2008..Of the seven point mutations, three were observed in at least one tumor from 49 other MPM patients. The mutations were in genes that could be causally related to cancer and included XRCC6, PDZK1IP1, ACTR1A, and AVEN... - Computed tomography features of nonalcoholic steatohepatitis with histopathologic correlationM Raquel Oliva
Division of Abdominal Imaging and Intervention, Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Comput Assist Tomogr 30:37-43. 2006..This study was conducted to describe the computed tomography (CT) features of nonalcoholic steatohepatitis (NASH) and to evaluate if the CT features could be used to diagnose and stage NASH... 
Renal cell carcinoma: t1 and t2 signal intensity characteristics of papillary and clear cell types correlated with pathologyM Raquel Oliva
Department of Radiology, Brigham and Women s Hospital, Boston, MA 02115, USA
AJR Am J Roentgenol 192:1524-30. 2009..The objective of our study was to describe the T1 and T2 signal intensity characteristics of papillary renal cell carcinoma (RCC) and clear cell RCC with pathologic correlation...- Identification of novel candidate oncogenes and tumor suppressors in malignant pleural mesothelioma using large-scale transcriptional profilingGavin J Gordon
Thoracic Surgery Oncology Laboratory, Division of Thoracic Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Am J Pathol 166:1827-40. 2005..Finally, we used bioinformatics tools (ie, software) to create and explore complex physiological pathways. Combined, all of these data may advance our understanding of mesothelioma tumorigenesis, pathobiology, or both... - Validation of genomics-based prognostic tests in malignant pleural mesotheliomaGavin J Gordon
Thoracic Surgery Oncology Laboratory and Division of Thoracic Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Clin Cancer Res 11:4406-14. 2005..In this report, we examine the accuracy of a previously proposed prognostic test in an independent cohort of MPM patients. This test uses simple ratios of gene expression levels to provide a novel prognostication scheme... - Brenner tumors of the ovary: sonographic and computed tomographic imaging featuresGretchen E Green
Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
J Ultrasound Med 25:1245-51; quiz 1252-4. 2006..The purpose of this study was to describe the sonographic appearance of ovarian Brenner tumors with computed tomographic (CT) correlation... - Morphologic features are useful in distinguishing Barrett esophagus from carditis with intestinal metaplasiaAmitabh Srivastava
Department of Pathology, Brigham and Women s Hospital, Boston, MA 02114, USA
Am J Surg Pathol 31:1733-41. 2007..Larger prospective studies need to be performed to validate these findings and evaluate the reproducibility of this approach in routine clinical practice... - CT and MRI features of pure acinar cell carcinoma of the pancreas in adultsServet Tatli
Department of Radiology, Division of Abdominal Imaging and Intervention, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
AJR Am J Roentgenol 184:511-9. 2005..We sought to describe the CT and MRI features of pure acinar cell carcinoma of the pancreas in adults... - Insights into developmental mechanisms and cancers in the mammalian intestine derived from serial analysis of gene expression and study of the hepatoma-derived growth factor (HDGF)Maina Lepourcelet
Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
Development 132:415-27. 2005..Our findings also advance understanding of HDGF functions and implicate this developmentally regulated gene in RNA metabolic pathways that may influence malignant behaviors in colorectal cancer... - Pancreatic intraductal papillary mucinous neoplasms: role of CT in predicting pathologic subtypesRahul Gupta
Department of Radiology, Division of Abdominal Imaging and Intervention, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
AJR Am J Roentgenol 191:1458-64. 2008..The objective of our study was to evaluate whether CT can be used to predict the pathologic subtypes of pancreatic intraductal papillary mucinous neoplasms (IPMNs)... - Pathologic features of reflux and Helicobacter pylori-associated carditis: a comparative studyTad J Wieczorek
Department of Pathology, Brigham and Women's Hospital, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
Am J Surg Pathol 27:960-8. 2003.... - Comparison of thyroid transcription factor-1 and hepatocyte antigen immunohistochemical analysis in the differential diagnosis of hepatocellular carcinoma, metastatic adenocarcinoma, renal cell carcinoma, and adrenal cortical carcinomaTad J Wieczorek
Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA
Am J Clin Pathol 118:911-21. 2002..Thus, these markers are usefulfor the characterization of HCC in tissue sections and cell blocks and are highly effective for distinguishing these tumors from other neoplasms included in the differential diagnosis... - CT findings in isolated ischemic proctosigmoiditisWalter Wiesner
Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Eur Radiol 12:1762-7. 2002.... - Multilayered epithelium in mucosal biopsy specimens from the gastroesophageal junction region is a histologic marker of gastroesophageal reflux diseaseJonathan N Glickman
Department of Pathology, Brigham and Women s Hospital, Boston, MA, USA
Am J Surg Pathol 33:818-25. 2009.... - Enterobacteriaceae act in concert with the gut microbiota to induce spontaneous and maternally transmitted colitisWendy S Garrett
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
Cell Host Microbe 8:292-300. 2010..Cross-fostering experiments indicated a role for these organisms in maternal transmission of disease. Our findings illustrate how gut microbial communities work in concert with specific culturable colitogenic agents to cause IBD... - Pancreatoblastoma in an adult woman: sonography, CT, and dynamic gadolinium-enhanced MRI featuresJoshua L Rosebrook
Division of Abdominal Imaging and Intervention, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
AJR Am J Roentgenol 184:S78-81. 2005 - Communicable ulcerative colitis induced by T-bet deficiency in the innate immune systemWendy S Garrett
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
Cell 131:33-45. 2007..These findings reveal a novel function for T-bet as a peacekeeper of host-commensal relationships and provide new perspectives on the pathophysiology of IBD... - Acute appendicitis is characterized by a uniform and highly selective pattern of inflammatory gene expressionC G Murphy
Division of Emergency Medicine, Children s Hospital, Boston, Massachusetts, USA
Mucosal Immunol 1:297-308. 2008.... - Pneumatosis intestinalis and portomesenteric venous gas in intestinal ischemia: correlation of CT findings with severity of ischemia and clinical outcomeW Wiesner
Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
AJR Am J Roentgenol 177:1319-23. 2001..The clinical outcome of patients with bowel ischemia with these CT findings seems to depend mainly on the severity and extent of their underlying disease... - Expression patterns of inhibitor of apoptosis proteins in malignant pleural mesotheliomaG J Gordon
The Thoracic Surgery Oncology Laboratory and the Division of Thoracic Surgery, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
J Pathol 211:447-54. 2007..Only IAP-1 and livin protein was expressed in the nucleus of MPM tumours. These results provide the rationale for additional study of this gene family in MPM and cancer in general... - Gangliocytoma masquerading as a prolactinoma. Case reportK C McCowen
Harvard Vanguard Medical Associates, Boston, Massachusetts, USA
J Neurosurg 91:490-5. 1999..Furthermore, in such instances, consideration should be given to "obtaining a biopsy sample prior to electing for radiotherapy... - XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel diseaseArthur Kaser
Division of Gastroenterology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
Cell 134:743-56. 2008..Hence, intestinal inflammation can originate solely from XBP1 abnormalities in IECs, thus linking cell-specific ER stress to the induction of organ-specific inflammation... - Clinical significance of colonic intraepithelial lymphocytosis in a pediatric populationRobert M Najarian
Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
Mod Pathol 22:13-20. 2009..These findings are similar to those seen in adults, with the exception of autoimmune enteropathy... - Colitis-associated colorectal cancer driven by T-bet deficiency in dendritic cellsWendy S Garrett
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
Cancer Cell 16:208-19. 2009..TRUC colitis-associated colorectal cancer resembles the human disease and provides ample opportunity to probe how inflammation drives colorectal cancer development and to test preventative and therapeutic strategies preclinically... - Resolvin E1, an endogenous lipid mediator derived from omega-3 eicosapentaenoic acid, protects against 2,4,6-trinitrobenzene sulfonic acid-induced colitisMakoto Arita
Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 102:7671-6. 2005..These findings show an endogenous mechanism that may underlie the beneficial actions of omega-3 EPA and provide targeted approaches for the treatment of intestinal inflammation... - Fas (CD95/APO-1) and Fas ligand expression in normal pancreas and pancreatic tumors. Implications for immune privilege and immune escapeWolfram V Bernstorff
Laboratory of Biologic Cancer Therapy, Division of Surgical Oncology, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
Cancer 94:2552-60. 2002..This may represent a mechanism by which pancreatic tumor cells become resistant to apoptosis and escape immune surveillance in vivo... - Section II: pathology and pathologic staging of esophageal cancerJonathan N Glickman
Department of Pathology, Harvard Medical School, Brigham and Women's Hospital, Boston, MA 02115, USA
Semin Thorac Cardiovasc Surg 15:167-79. 2003..Early detection and treatment of these tumors is the most important factor in patient survival... - MR imaging features of solid pseudopapillary tumor of the pancreas in adult and pediatric patientsVito Cantisani
Section of Abdominal Imaging and Intervention, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
AJR Am J Roentgenol 181:395-401. 2003..These features help differentiate this rare tumor from other pancreatic neoplasms... - Matrix metalloproteinases in the urine and tissue of patients with juvenile polyps: potential biomarkers for the presence of polypsMichael A Manfredi
Division of Gastroenterology, Children s Hospital Boston and Harvard Medical School, Boston, MA, USA
J Pediatr Gastroenterol Nutr 48:405-11. 2009..We hypothesized that the presence of these enzymes in urine may serve as clinical biomarkers of juvenile polyps... - CT features of hepatic venoocclusive disease and hepatic graft-versus-host disease in patients after hematopoietic stem cell transplantationSukru Mehmet Erturk
Division of Abdominal Imaging and Intervention, Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Radiology Ste, c o One Brigham Circle, 1620 Tremont St, Boston, MA 02120, USA
AJR Am J Roentgenol 186:1497-501. 2006..We conducted this study to evaluate whether CT scans could be used to differentiate hepatic venoocclusive disease from hepatic graft-versus-host disease in patients treated with hematopoietic stem cell transplantation... - Vaginal metastasis from uterine leiomyosarcoma. Magnetic resonance imaging features with pathological correlationVito Cantisani
Department of Radiology, Brigham and Women's Hospital, Boston, MA 02115, USA
J Comput Assist Tomogr 27:805-9. 2003..The magnetic resonance imaging features are described and correlated with the pathological findings. To the best of our knowledge, this is the first case of vaginal metastasis from uterine leiomyosarcoma described in the literature... - Variability of histopathological changes in childhood celiac diseaseDascha C Weir
Department of Pathology, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Am J Gastroenterol 105:207-12. 2010..Adult studies of celiac disease (CD) have shown that duodenal mucosal histopathological changes may be patchy, and the diagnostic utility of duodenal bulb biopsies is believed to be limited. Few related pediatric data exist... - Specific regulation of T helper cell 1-mediated murine colitis by CEACAM1Hideki Iijima
Gastroenterology Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
J Exp Med 199:471-82. 2004.... - CT features with pathologic correlation of acute gastrointestinal graft-versus-host disease after bone marrow transplantation in adultsBabak N Kalantari
Department of Radiology, Section of Abdominal Imaging and Intervention, Brigham and Women's Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
AJR Am J Roentgenol 181:1621-5. 2003..CT findings associated with high-grade graft-versus-host disease are thickening of the distal esophagus, ileum, or ascending colon, as well as increasing numbers of thickened bowel wall segments... - High-resolution analysis of genetic alterations in small bowel carcinoid tumors reveals areas of recurrent amplification and lossMatthew H Kulke
Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, USA
Genes Chromosomes Cancer 47:591-603. 2008..This detailed study of an uncommon neoplasm provides a basis to investigate putative oncogenes and tumor suppressor genes in intestinal carcinoid tumors... - Carcinoid tumorsChandrajit P Raut
Harvard Medical School, Boston, Massachusetts, USA
Curr Probl Surg 43:383-450. 2006 - Neonatal Fc receptor for IgG regulates mucosal immune responses to luminal bacteriaMasaru Yoshida
Department of Medicine, Brigham and Women s Hospital, and Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA
J Clin Invest 116:2142-2151. 2006.... - Pathophysiological preconditions promoting mixed "black" pigment plus cholesterol gallstones in a DeltaF508 mouse model of cystic fibrosisFolke Freudenberg
Department of Medicine, Harvard Medical School and Harvard Digestive Diseases Center Department of Medicine, Gastroenterology Division, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
Am J Physiol Gastrointest Liver Physiol 299:G205-14. 2010..This is an initial step toward unraveling the molecular basis of CF gallstone disease and constitutes a framework for investigating animal models of CF with more severe biliary disease, as well as the human disease... - A mutation in separase causes genome instability and increased susceptibility to epithelial cancerJennifer L Shepard
Children s Hospital, Boston, Massachusetts 02115, USA
Genes Dev 21:55-9. 2007..These data strongly support a conserved cross-species role for mitotic checkpoint genes in genetic stability and epithelial carcinogenesis... - Smooth muscle remodeling of the gastroesophageal junction after endoluminal gastroplicationJulia J Liu
Division of Gastroenterology, Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Gastrointest Endosc 65:1023-7. 2007..Despite suture loss, some patients have persistent symptomatic resolution... - Obesity-related fatty liver is unchanged in mice deficient for mitochondrial uncoupling protein 2GYORGY BAFFY
Division of Endocrinology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
Hepatology 35:753-61. 2002..We conclude that increased expression of UCP2 in the livers of mice with genetically or diet-induced obesity exerts neither protective nor deleterious effects on the severity of fatty liver disease... - Significance of squamous metaplasia-like change in the esophagusRobert D Odze
Am J Surg Pathol 29:1259-61; author reply 1261-3. 2005 - Portal-venous gas unrelated to mesenteric ischemiaWalter Wiesner
Department of Radiology, Brigham and Women's Hospital, Harvard Medic Petersgraben 4, 4031 Basel, Switzerland. wwiesner @uhbs.ch
Eur Radiol 12:1432-7. 2002..The knowledge about these conditions may help to avoid misinterpretation of CT findings, inappropriate clinical uncertainty and unnecessary surgery in certain cases... - Differentiating ulcerative colitis from Crohn disease in children and young adults: report of a working group of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the Crohn's and Colitis Foundation of AmericaAthos Bousvaros
J Pediatr Gastroenterol Nutr 44:653-74. 2007..quot; The authors hope that progress being made in genetic, serological, and imaging studies leads to more reliable phenotyping... - Mast cells are an essential hematopoietic component for polyp developmentElias Gounaris
Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Proc Natl Acad Sci U S A 104:19977-82. 2007..Our data suggest that MC are an essential hematopoietic component for preneoplastic polyp development and are a novel target for therapeutic intervention... - Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colonKevin M Haigis
Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Nat Genet 40:600-8. 2008..These studies demonstrate clear phenotypic differences between mutant Kras and Nras, and suggest that the oncogenic phenotype of mutant K-Ras might be mediated by noncanonical signaling through Ras effector pathways...