Michael M Givertz

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. doi request reprint Acute decompensated heart failure: update on new and emerging evidence and directions for future research
    Michael M Givertz
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Card Fail 19:371-89. 2013
  2. ncbi request reprint The effects of KW-3902, an adenosine A1-receptor antagonist,on diuresis and renal function in patients with acute decompensated heart failure and renal impairment or diuretic resistance
    Michael M Givertz
    Cardiovascular Division, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Am Coll Cardiol 50:1551-60. 2007
  3. ncbi request reprint Direct myocardial effects of levosimendan in humans with left ventricular dysfunction: alteration of force-frequency and relaxation-frequency relationships
    Michael M Givertz
    Cardiomyopathy Program and Cardiovascular Section, Boston University Medical Center, Boston, Mass, USA
    Circulation 115:1218-24. 2007
  4. ncbi request reprint Renal function trajectories and clinical outcomes in acute heart failure
    Michael M Givertz
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA
    Circ Heart Fail 7:59-67. 2014
  5. pmc Effect of admission oral diuretic dose on response to continuous versus bolus intravenous diuretics in acute heart failure: an analysis from diuretic optimization strategies in acute heart failure
    Ravi V Shah
    Cardiovascular Division, Massachusetts General Hospital, Boston, USA
    Am Heart J 164:862-8. 2012
  6. pmc Right ventricular dysfunction during intensive pharmacologic unloading persists after mechanical unloading
    Maryse Palardy
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    J Card Fail 16:218-24. 2010
  7. doi request reprint Pediatric heart failure and worsening renal function: association with outcomes after heart transplantation
    Satish K Rajagopal
    Department of Cardiology, Children s Hospital Boston, Boston, MA 02115, USA
    J Heart Lung Transplant 31:252-8. 2012
  8. doi request reprint The association between high-dose diuretics and clinical stability in ambulatory chronic heart failure patients
    Lisa M Mielniczuk
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Card Fail 14:388-93. 2008
  9. ncbi request reprint Managing acute renal failure in patients with acute decompensated heart failure: the cardiorenal syndrome
    Ravi V Shah
    Cardiovascular Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    Curr Heart Fail Rep 6:176-81. 2009
  10. doi request reprint Improved survival in heart transplant recipients in the United States: racial differences in era effect
    Tajinder P Singh
    Department of Cardiology, Children s Hospital Boston, Boston, MA 02115, USA
    Circ Heart Fail 4:153-60. 2011

Research Grants

  1. NO AND OXIDATIVE STRESS IN HUMAN MYOCARDIAL FAILURE
    Michael Givertz; Fiscal Year: 2003

Detail Information

Publications36

  1. doi request reprint Acute decompensated heart failure: update on new and emerging evidence and directions for future research
    Michael M Givertz
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Card Fail 19:371-89. 2013
    ..Although many gaps in knowledge exist, ongoing studies will address issues around delivery of evidence-based care to achieve the goal of improving the health status and clinical outcomes of patients with ADHF...
  2. ncbi request reprint The effects of KW-3902, an adenosine A1-receptor antagonist,on diuresis and renal function in patients with acute decompensated heart failure and renal impairment or diuretic resistance
    Michael M Givertz
    Cardiovascular Division, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Am Coll Cardiol 50:1551-60. 2007
    ..This study sought to evaluate the dose-dependent effects of adenosine A1-receptor blockade on diuresis and renal function in patients with acute decompensated heart failure (ADHF) and renal impairment or diuretic resistance...
  3. ncbi request reprint Direct myocardial effects of levosimendan in humans with left ventricular dysfunction: alteration of force-frequency and relaxation-frequency relationships
    Michael M Givertz
    Cardiomyopathy Program and Cardiovascular Section, Boston University Medical Center, Boston, Mass, USA
    Circulation 115:1218-24. 2007
    ..We sought to determine the direct effects of levosimendan on failing human myocardium in vivo, and in particular whether levosimendan exerts heart rate-dependent effects on systolic or diastolic function...
  4. ncbi request reprint Renal function trajectories and clinical outcomes in acute heart failure
    Michael M Givertz
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA
    Circ Heart Fail 7:59-67. 2014
    ..Prior studies have demonstrated adverse risk associated with baseline and worsening renal function in acute heart failure, but none has modeled the trajectories of change in renal function and their impact on outcomes...
  5. pmc Effect of admission oral diuretic dose on response to continuous versus bolus intravenous diuretics in acute heart failure: an analysis from diuretic optimization strategies in acute heart failure
    Ravi V Shah
    Cardiovascular Division, Massachusetts General Hospital, Boston, USA
    Am Heart J 164:862-8. 2012
    ..We hypothesized that outpatient furosemide dose was associated with congestion and poorer renal function and explored the hypothesis that a continuous infusion may be more effective in patients on higher outpatient diuretic doses...
  6. pmc Right ventricular dysfunction during intensive pharmacologic unloading persists after mechanical unloading
    Maryse Palardy
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    J Card Fail 16:218-24. 2010
    ..We compared RV size and function after aggressive medical unloading therapy to that achieved in the same patients after 3 months of left ventricular assist device (LVAD) support...
  7. doi request reprint Pediatric heart failure and worsening renal function: association with outcomes after heart transplantation
    Satish K Rajagopal
    Department of Cardiology, Children s Hospital Boston, Boston, MA 02115, USA
    J Heart Lung Transplant 31:252-8. 2012
    ..This study was initiated to assess the effects of worsening renal function (WRF) on post-heart transplantation outcomes and to determine the effect of waiting-list associated WRF on survival after heart transplantation...
  8. doi request reprint The association between high-dose diuretics and clinical stability in ambulatory chronic heart failure patients
    Lisa M Mielniczuk
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Card Fail 14:388-93. 2008
    ..In chronic heart failure (HF), diuretic doses increase as the disease progresses, often after hospitalization for instability, and have been associated with worsening renal function and increased mortality...
  9. ncbi request reprint Managing acute renal failure in patients with acute decompensated heart failure: the cardiorenal syndrome
    Ravi V Shah
    Cardiovascular Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    Curr Heart Fail Rep 6:176-81. 2009
    ....
  10. doi request reprint Improved survival in heart transplant recipients in the United States: racial differences in era effect
    Tajinder P Singh
    Department of Cardiology, Children s Hospital Boston, Boston, MA 02115, USA
    Circ Heart Fail 4:153-60. 2011
    ..Posttransplant survival in heart transplant recipients has progressively improved during the past 2 decades. It is unknown, however, whether the major racial groups in the United States have benefited equally...
  11. doi request reprint The effect of renin-angiotensin system inhibitors on mortality and heart failure hospitalization in patients with heart failure and preserved ejection fraction: a systematic review and meta-analysis
    Ravi V Shah
    Cardiology Division, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA
    J Card Fail 16:260-7. 2010
    ....
  12. doi request reprint Management of acute right ventricular failure in the intensive care unit
    Eric M Green
    Cardiovascular Division, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Curr Heart Fail Rep 9:228-35. 2012
    ..In this review, we present a contemporary approach to patients with acute failure of the right ventricle including strategies for mechanical ventilation, hemodynamic management, and mechanical circulatory support...
  13. doi request reprint Clinical predictors of hepatic fibrosis in chronic advanced heart failure
    Jill M Gelow
    Cardiovascular Division, Brigham and Women s Hospital, Boston, MA, USA
    Circ Heart Fail 3:59-64. 2010
    ..We investigated the histopathologic spectrum of liver disease in a contemporary population with heart failure to identify the clinical correlates of hepatic fibrosis...
  14. ncbi request reprint Epicardial left ventricular lead placement for cardiac resynchronization therapy following failed coronary sinus approach
    Ravi V Shah
    Harvard Medical School, Boston, MA, USA
    Congest Heart Fail 12:312-6. 2006
    ..Thus, in patients with unsuccessful percutaneous CRT, epicardial LV lead placement is associated with perioperative morbidity, but with subsequent improvement in functional status without excess mortality...
  15. ncbi request reprint Heart failure and diabetes: collateral benefit of chronic disease management
    Molly G Ware
    Department of Medicine, Cardiovascular Division, Advanced Heart Disease Program, Brigham and Women s Hospital, Boston, MA 02115, USA
    Congest Heart Fail 12:132-6. 2006
    ..quot;Collateral benefit" of HF disease management may contribute to improved patient outcomes in diabetic patients with HF...
  16. pmc Functionally competent cardiac stem cells can be isolated from endomyocardial biopsies of patients with advanced cardiomyopathies
    Domenico D'Amario
    Departments of Anesthesia and Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Circ Res 108:857-61. 2011
    ....
  17. ncbi request reprint Discharge outcomes in patients with paracorporeal biventricular assist devices
    Sunu S Thomas
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts
    Ann Thorac Surg 97:894-900. 2014
    ..Because most reported post-discharge experience is with left ventricular assist devices (LVAD), we sought to evaluate the safety and feasibility of home discharge on paracorporeal biventricular assist devices (BIVAD)...
  18. pmc VEGF-C, VEGF-A and related angiogenesis factors as biomarkers of allograft vasculopathy in cardiac transplant recipients
    Kevin P Daly
    Transplantation Research Center, Division of Nephrology, Department of Medicine, Boston Children s Hospital, Boston, Massachusetts 02115, USA
    J Heart Lung Transplant 32:120-8. 2013
    ..Graft vascular endothelial cells (EC) are primary targets of these destructive responses, suggesting that factors associated with endothelial injury and repair could serve as biomarkers of CAV...
  19. doi request reprint Indications for cardiac resynchronization therapy: 2011 update from the Heart Failure Society of America Guideline Committee
    William G Stevenson
    Department of Medicine, Division of Cardiology Brigham and Women s Hospital, Boston, Massachusetts, USA
    J Card Fail 18:94-106. 2012
    ..Recommendations will evolve over time as additional data emerge from completed and ongoing clinical trials...
  20. doi request reprint Patient expectations from implantable defibrillators to prevent death in heart failure
    Garrick C Stewart
    Division of Cardiovascular Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Card Fail 16:106-13. 2010
    ..This study examined patient expectations from ICDs for primary prevention of sudden death in HF...
  21. doi request reprint Multimodality imaging of an adult with Shone complex
    Marcio Sommer Bittencourt
    Non invasive Cardiovascular Imaging Program, Departments of Medicine Cardiovascular Division and Radiology, Brigham and Women s Hospital, Boston, MA, USA
    J Cardiovasc Comput Tomogr 7:62-5. 2013
    ..This article presents an unusual case of a 40-year-old woman who presented with a history of progressive dyspnea. We describe the main imaging features and protocol used for visualizing this syndrome using various imaging modalities...
  22. ncbi request reprint Frequency and impact of delayed decisions regarding heart transplantation on long-term outcomes in patients with advanced heart failure
    Eldrin F Lewis
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Am Coll Cardiol 43:794-802. 2004
    ..We sought to characterize decisions regarding listing of heart transplant candidates and to determine the impact of delayed listing for a transplant on survival...
  23. doi request reprint Role of adenosine antagonism in the cardiorenal syndrome
    Mustafa M Dohadwala
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Cardiovasc Ther 26:276-86. 2008
    ..In this article, we review the cardiorenal syndrome, the role of adenosine in renal function, and emerging data regarding the safety and efficacy of adenosine A1 receptor antagonists in patients with advanced HF...
  24. doi request reprint Handheld echocardiography offers rapid assessment of clinical volume status
    Viviane T Q Nguyen
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Am Heart J 156:537-42. 2008
    ..In this study, we evaluated the feasibility and accuracy of handheld echocardiography by a nonexpert for potential use in the point of care evaluation of compensation...
  25. doi request reprint Socioeconomic position, ethnicity, and outcomes in heart transplant recipients
    Tajinder P Singh
    Department of Cardiology, Children s Hospital Boston, Boston, Massachusetts Harvard Medical School, Boston, Massachusetts, USA
    Am J Cardiol 105:1024-9. 2010
    ..In conclusion, among heart transplant recipients who survive the transplant hospitalization, nonwhite recipients and those in a low SE position are at greater risk of rejection and graft loss...
  26. pmc Assessment of myocardial viability and left ventricular function in patients supported by a left ventricular assist device
    Deepak K Gupta
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts
    J Heart Lung Transplant 33:372-81. 2014
    ..We aimed to develop a non-invasive imaging protocol to serially quantify native cardiac structure, function, and myocardial viability while at reduced LVAD support...
  27. doi request reprint Novel biomarkers in acute heart failure
    Marat Yanavitski
    Cardiovascular Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    Curr Heart Fail Rep 8:206-11. 2011
    ....
  28. ncbi request reprint Endothelin mediates increased pulmonary vascular tone in patients with heart failure: demonstration by direct intrapulmonary infusion of sitaxsentan
    Henry Ooi
    Cardiovascular Section, Department of Medicine and the Cardiomyopathy Program, Boston University School of Medicine, Boston, Mass, USA
    Circulation 106:1618-21. 2002
    ..The role of ET in causing pulmonary vasoconstriction in HF is not known, however, in part because of the confounding effects of ET receptor antagonists on systemic hemodynamics...
  29. ncbi request reprint Intensity and focus of heart failure disease management after hospital discharge
    Monica R Shah
    Division of Cardiology, Center for Advanced Cardiac Care, Columbia University Medical Center, Durham, NC, USA
    Am Heart J 149:715-21. 2005
    ..Although features of heart failure disease management programs are broadly outlined, little is known about which interventions are actually used in the outpatient setting or which patients are most likely to require interventions...
  30. doi request reprint Usefulness of B-type natriuretic peptide and cardiac troponin levels to predict in-hospital mortality from ADHERE
    Gregg C Fonarow
    Ahmanson UCLA Cardiomyopathy Center, University of California, Los Angeles Medical Center, Los Angeles, California, USA
    Am J Cardiol 101:231-7. 2008
    ..In conclusion, a multimarker strategy for the assessment of patients hospitalized with HF adds incremental prognostic information...
  31. ncbi request reprint Admission B-type natriuretic peptide levels and in-hospital mortality in acute decompensated heart failure
    Gregg C Fonarow
    Ahmanson UCLA Cardiomyopathy Center, University of California, Los Angeles Medical Center, Los Angeles, California, USA
    J Am Coll Cardiol 49:1943-50. 2007
    ..This study was designed to determine whether admission B-type natriuretic peptide (BNP) levels are predictive of in-hospital mortality in acute decompensated heart failure (HF)...
  32. ncbi request reprint Impact of oxypurinol in patients with symptomatic heart failure. Results of the OPT-CHF study
    Joshua M Hare
    The University of Miami Miller School of Medicine, Miami, Florida v, USA
    J Am Coll Cardiol 51:2301-9. 2008
    ....
  33. ncbi request reprint Modulation of myocardial energetics: emerging evidence for a therapeutic target in cardiovascular disease
    David A Morrow
    Circulation 112:3218-21. 2005
  34. ncbi request reprint Rationale, design and organisation of an efficacy and safety study of oxypurinol added to standard therapy in patients with NYHA class III - IV congestive heart failure
    Ronald S Freudenberger
    Univerfsity of Medicine and Dentistry of New Jersey, USA
    Expert Opin Investig Drugs 13:1509-16. 2004
    ..The efficacy end point for OPT-CHF is a composite that incorporates measures of patient outcome and well-being...
  35. ncbi request reprint Exhaled nitric oxide: a marker of pulmonary hemodynamics in heart failure
    Joshua M Hare
    Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    J Am Coll Cardiol 40:1114-9. 2002
    ..We sought to test the hypothesis that patients with decompensated heart failure (HF) lose a compensatory process whereby nitric oxide (NO) maintains pulmonary vascular tone...
  36. ncbi request reprint B-type natriuretic peptide and the stressed heart
    Anju Nohria
    J Am Coll Cardiol 47:749-51. 2006

Research Grants1

  1. NO AND OXIDATIVE STRESS IN HUMAN MYOCARDIAL FAILURE
    Michael Givertz; Fiscal Year: 2003
    ..abstract_text> ..